Biological medicines for asthma

RX_ASTMA_BIOL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC R03DX05|R03DX08|R03DX09|R03DX10|D11AH05

1 out of 7 registries used, show all original rules.

478

4. Check minimum number of events

Min. number of events 3
478

5. Include endpoints

None

478

6. Filter based on genotype QC (FinnGen only)

478

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1297 753 538
Only index persons 1280 749 531
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 50.20 49.28 51.58
Only index persons 50.32 49.31 51.75

-FinnGen-

Key figures

All Female Male
Number of individuals 478 298 180
Unadjusted period prevalence (%) 0.09 0.10 0.08
Median age at first event (years) 55.71 55.44 56.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
318
Matched controls
3180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R03DC03
ATC
montelukast; oral
41.9
169.8
263
325
344
Kela drug reimbursment
Omalizumab
+∞
128.0
114
*
R03DX05
ATC
omalizumab; parenteral
+∞
128.0
114
*
R03BB04
ATC
tiotropium bromide; inhalant
35.4
126.4
171
101
H02AB06
ATC
prednisolone; systemic
62.5
126.3
307
981
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
18.7
115.5
227
373
J45.0
ICD-10 Finland
Predominantly allergic asthma
23.6
109.4
171
149
ZX112
NOMESCO Finland
Subcutaneous
82.3
105.7
116
22
395
Kela drug reimbursment
Dupilumab
+∞
98.1
89
*
D11AH05
ATC
dupilumab; topical
+∞
96.9
88
*
J45.9
ICD-10 Finland
Asthma, unspecified
14.2
94.0
198
330
R03AK08
ATC
formoterol and beclometasone; inhalant
34.3
88.4
117
53
297
Kela drug reimbursment
NA
+∞
87.6
80
*
3028
Kela drug reimbursment
Mepolizumab
+∞
87.6
80
*
R03DX09
ATC
mepolizumab; parenteral
+∞
85.3
78
*
XG474
NOMESCO Finland
Exhalation nntrogen oxide
41.1
81.2
102
36
J45.1
ICD-10 Finland
Nonallergic asthma
17.6
73.2
123
110
R06AX27
ATC
desloratadine; oral
8.7
68.1
218
639
R03DA04
ATC
theophylline; systemic, rectal
27.0
61.4
86
43
J46
ICD-10 Finland
Status asthmaticus
32.4
59.6
79
32
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
14.7
56.1
100
96
3027
Kela drug reimbursment
Benralizumab
+∞
54.8
51
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
9.1
53.9
131
228
R03DX10
ATC
benralizumab; systemic
+∞
53.7
50
*
R03BA08
ATC
ciclesonide; inhalant
10.8
51.7
109
146
UDH02
NOMESCO Finland
Rhinopharyngoscopy
13.1
51.6
97
103
R03AC02
ATC
salbutamol; inhalant
7.8
51.6
268
1299
J32.4
ICD-10 Finland
Chronic pansinusitis
41.8
51.6
64
19
251
Kela drug reimbursment
NA
+∞
50.4
47
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
23.3
50.1
73
40
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
10.8
49.9
105
139
R01AD08
ATC
fluticasone; nasal
5.9
46.9
191
649
TDM10
NOMESCO Finland
Puncture of maxillary antrum
16.6
46.5
77
60
R03BA02
ATC
budesonide; inhalant
6.7
46.3
144
347
R06AE09
ATC
levocetirizine; oral
7.0
45.8
135
301
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
31.2
44.4
59
23
C01CA24
ATC
epinephrine; parenteral
10.3
44.2
94
124
XQ800
NOMESCO Finland
Prick test
8.9
44.2
104
164
L50.9
ICD-10 Finland
Urticaria, unspecified
17.7
43.0
69
49
R06AE07
ATC
cetirizine; oral
5.4
42.3
231
1045
R03AK07
ATC
formoterol and budesonide; inhalant
6.0
42.0
147
401
R03AC13
ATC
formoterol; inhalant
14.7
42.0
73
63
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
32.4
39.6
52
19
L50.1
ICD-10 Finland
Idiopathic urticaria
65.2
39.5
45
8
D11AH01
ATC
tacrolimus; topical
38.3
38.9
49
15
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
70.7
38.2
43
7
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.7
38.1
78
94
J45.8
ICD-10 Finland
Mixed asthma
20.8
38.0
57
33
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
16.1
38.0
63
48
J45
ICD-10 Finland
Asthma
7.5
37.5
99
181
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
25.6
37.1
52
24
R03AC12
ATC
salmeterol; inhalant
16.9
37.0
60
43
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
12.8
36.9
68
66
R03AK11
ATC
formoterol and fluticasone; inhalant
22.2
36.8
54
29
J33.0
ICD-10 Finland
Polyp of nasal cavity
17.4
36.8
59
41
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
11.4
36.2
71
78
L20.0
ICD-10 Finland
Besnier prurigo
8.9
35.5
81
117
L04AD01
ATC
ciclosporin; systemic
26.1
35.2
49
22
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.5
34.9
65
64
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
34.8
193
816
R96
ICPC
Asthma
8.0
33.7
83
135
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
15.6
33.5
56
43
R06AX22
ATC
ebastine; oral
5.2
33.1
126
359
H02AB07
ATC
prednisone; oral
6.2
33.0
101
222
L50.8
ICD-10 Finland
Other urticaria
18.7
32.9
51
32
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
13.9
31.9
56
48
WZC30
NOMESCO Finland
Teaching
6.2
31.5
96
208
J33.8
ICD-10 Finland
Other polyp of sinus
17.2
31.3
50
34
D11AX14
ATC
[U] tacrolimus; topical
57.7
31.0
36
7
R03BA05
ATC
fluticasone; inhalant
4.8
30.7
126
383
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
6.5
29.9
86
172
H02AB09
ATC
hydrocortisone; systemic
21.4
29.2
43
23
D11AH02
ATC
pimecrolimus; topical
114.1
29.2
31
*
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
4.3
28.7
137
477
H02AB04
ATC
methylprednisolone; systemic
5.1
28.1
102
268
D07AB08
ATC
desonide; topical
5.8
27.4
86
190
E0000UV
ATC
NA
3.6
26.0
182
857
D07AC01
ATC
betamethasone; topical
3.7
26.0
157
658
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
39.3
25.7
32
9
R03BA01
ATC
beclometasone; inhalant
4.8
25.6
98
269
R01AD12
ATC
fluticasone furoate; nasal
3.6
25.6
165
726
49300
ICD-8 Finland
Asthma, bronchiale
19.4
25.1
38
22
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
24.5
135
515
J01MA14
ATC
moxifloxacin; systemic
6.6
24.5
67
123
R01AD09
ATC
mometasone; nasal
3.4
24.2
202
1067
D07AA02
ATC
hydrocortisone; topical
4.6
23.7
95
271
UDM02
NOMESCO Finland
Sinoscopy
12.2
22.9
42
39
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
6.8
22.6
60
105
L50.3
ICD-10 Finland
Dermatographic urticaria
20.3
22.2
33
18
XG410
NOMESCO Finland
Flow-volume spirometry
9.1
22.2
48
61
3DX05
NOMESCO Finland
NA
123.5
21.9
23
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
28.8
21.8
29
11
R06AX13
ATC
loratadine; oral
4.0
21.4
102
338
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.2
21.3
219
1293
S01GX01
ATC
cromoglicic acid; ophthalmic
3.6
21.1
117
439
R03AC03
ATC
terbutaline; inhalant
4.2
21.0
92
282
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.0
20.6
97
317
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.5
20.2
118
459
R06.0
ICD-10 Finland
Dyspnoea
3.6
20.2
109
398
J01FA09
ATC
clarithromycin; systemic
3.1
20.0
153
724
R06AX26
ATC
fexofenadine; oral
6.3
20.0
56
105
J01FA10
ATC
azithromycin; systemic
3.2
19.8
240
1547
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.6
19.8
75
199
J01FA06
ATC
roxithromycin; oral
3.0
19.6
171
882
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
33.7
19.6
25
8
D02AE01
ATC
carbamide; topical
6.1
19.3
55
105
D07AB02
ATC
hydrocortisone butyrate; topical
3.3
19.2
129
551
TQW80
NOMESCO Finland
Local dermatologic skincare
12.5
19.0
34
30
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.1
19.0
48
78
D72.1
ICD-10 Finland
Eosinophilia
74.5
18.9
21
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
106.4
18.8
20
*
134
Kela drug reimbursment
General erythroderma
201.3
18.7
19
*
E000002
ATC
NA
4.6
18.7
71
188
R01AD05
ATC
budesonide; nasal
5.2
18.5
61
139
D11AX15
ATC
[U] pimecrolimus; topical
55.9
18.2
21
*
J31.0
ICD-10 Finland
Chronic rhinitis
5.6
17.7
54
112
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.3
16.8
68
190
R02
ICPC
Shortness of breath/dyspnoea
4.3
16.4
65
178
J01AA02
ATC
doxycycline; systemic
3.3
16.2
269
1978
TGC00
NOMESCO Finland
Bronchial lavation
13.2
16.2
28
23
E000001
ATC
NA
3.2
16.2
102
409
ZXA10
NOMESCO Finland
Bilateral
3.5
15.9
84
293
E000003
ATC
NA
7.1
15.8
39
61
DHB20
NOMESCO Finland
Polypectomy of internal nose
14.0
15.5
26
20
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.5
15.5
82
287
J47
ICD-10 Finland
Bronchiectasis
18.9
15.4
23
13
D02AX
ATC
Other emollients and protectives
8.1
15.2
34
46
R03DC01
ATC
zafirlukast; oral
16.1
15.1
24
16
XQ802
NOMESCO Finland
Epicutan test
6.4
14.6
39
68
R01AD11
ATC
triamcinolone; nasal
4.5
14.6
54
138
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.4
14.5
55
144
DPA30
NOMESCO Finland
Sphenotomy
28.7
14.4
19
7
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
20.3
14.4
21
11
J33.9
ICD-10 Finland
Nasal polyp, unspecified
20.3
14.4
21
11
E000007
ATC
NA
5.5
13.7
41
83
R01AD01
ATC
beclometasone; nasal
3.2
13.6
83
320
R01BA52
ATC
pseudoephedrine, combinations; oral
2.6
13.3
131
676
A02BC02
ATC
pantoprazole; systemic
2.5
13.2
217
1472
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
17.7
13.2
20
12
DHB50
NOMESCO Finland
Turbinoplasty
9.3
12.8
26
30
J01FF01
ATC
clindamycin; systemic
2.7
12.4
107
507
R03BC03
ATC
nedocromil; inhalant
4.6
12.2
43
104
Z51.6
ICD-10 Finland
Desensitization to allergens
10.7
12.2
23
23
N05BB01
ATC
hydroxyzine; systemic
4.5
12.0
43
106
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
10.2
12.0
23
24
D09AB01
ATC
zinc bandage without supplements; topical
10.2
12.0
23
24
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.6
11.8
41
98
J01FA15
ATC
telithromycin; oral
3.4
11.8
61
208
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
31.3
11.7
15
5
Z88.6
ICD-10 Finland
Personal history of allergy to analgesic agent
67.5
11.7
13
*
J34.2
ICD-10 Finland
Deviated nasal septum
5.1
11.7
37
80
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
11.7
137
766
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.5
11.6
113
575
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.9
11.5
49
142
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
124.3
11.5
12
*
J30.3
ICD-10 Finland
Other allergic rhinitis
6.0
11.4
31
56
N02AX02
ATC
tramadol; systemic, rectal
2.3
11.2
148
873
XQ848
NOMESCO Finland
Dermatological photography
10.6
11.2
21
21
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
29.2
10.8
14
5
L26
ICD-10 Finland
Exfoliative dermatitis
62.1
10.7
12
*
J01DA01
ATC
[U] cefalexin; systemic
2.2
10.5
214
1522
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
113.6
10.5
11
*
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
12.6
10.5
18
15
D07AC13
ATC
mometasone; topical
2.4
10.3
111
585
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
10.6
10.2
19
19
L50.0
ICD-10 Finland
Allergic urticaria
6.0
10.1
27
48
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
17.4
10.0
15
9
A02BC05
ATC
esomeprazole; systemic
2.2
9.8
138
821
R03BB01
ATC
ipratropium bromide; inhalant
7.0
9.6
23
35
DJD20
NOMESCO Finland
Plastic repair of septum of nose
5.7
9.6
27
51
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
5.7
9.6
27
51
J02AC01
ATC
fluconazole; systemic
2.2
9.6
149
924
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
12.9
9.5
16
13
WW200
NOMESCO Finland
Immunization
5.8
9.4
26
48
N02AJ06
ATC
codeine and paracetamol; systemic
2.1
9.4
140
852
J01DB01
ATC
cefalexin; oral
2.6
9.4
275
2252
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
9.3
138
838
T78.4
ICD-10 Finland
Allergy, unspecified
4.4
9.3
33
81
R06AX18
ATC
acrivastine; oral
6.4
9.1
23
38
D07CC01
ATC
betamethasone and antibiotics; topical
3.0
9.1
55
208
D07AD01
ATC
clobetasol; topical
2.7
9.0
64
267
L27.2
ICD-10 Finland
Dermatitis due to ingested food
13.0
9.0
15
12
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.1
8.9
169
1129
D07AC14
ATC
methylprednisolone aceponate; topical
4.7
8.8
29
66
L04AX01
ATC
azathioprine; systemic
4.4
8.8
31
76
A07AA02
ATC
nystatin; oral
4.3
8.6
31
77
G47.3
ICD-10 Finland
Sleep apnoea
2.4
8.5
81
395
A02BC01
ATC
omeprazole; systemic
2.3
8.5
91
472
E000006
ATC
NA
3.7
8.5
37
110
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.5
8.5
21
34
4AC06
NOMESCO Finland
NA
92.4
8.5
9
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
92.4
8.5
9
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.5
8.3
73
340
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
5.0
8.3
26
56
R05
ICD-10 Finland
Cough
2.5
8.2
71
331
L50
ICD-10 Finland
Urticaria
7.1
8.2
19
28
WQ000
NOMESCO Finland
Hyposensibilisation
12.1
8.2
14
12
49302
ICD-8 Finland
Asthma, Rhinitis allergica cum asthmate bronchiali
34.3
8.1
10
*
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
10.4
8.1
15
15
N02BE01
ATC
paracetamol; systemic, rectal
2.4
8.0
273
2273
R06.2
ICD-10 Finland
Wheezing
4.1
7.9
30
79
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
7.9
81
408
S88
ICPC
Dermatitis contact/allergic
9.8
7.9
15
16
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
7.7
7.8
17
23
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
15.5
7.8
12
8
A02BA02
ATC
ranitidine; systemic
2.4
7.5
67
317
A01AB09
ATC
miconazole; local oral
3.3
7.5
37
122
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
13.8
7.4
12
9
T78.3
ICD-10 Finland
Angioneurotic oedema
11.2
7.4
13
12
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.1
7.4
96
540
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
6.5
7.4
18
29
ZX110
NOMESCO Finland
Intracutaneous
+∞
7.3
7
*
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
6.8
7.2
17
26
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
5.5
7.2
20
38
J04BA02
ATC
dapsone; oral
20.6
7.2
10
5
M05BA04
ATC
alendronic acid; oral
4.2
7.2
26
66
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.7
7.1
30
87
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
12.4
7.1
12
10
J01DC02
ATC
cefuroxime; systemic
3.5
7.0
31
94
R51.80
ICD-10 Finland
Headache
2.4
6.9
60
279
ZXC95
NOMESCO Finland
Use of surgical navigator
11.3
6.9
12
11
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.8
89
496
J01MA12
ATC
levofloxacin; systemic
2.4
6.8
60
280
D07XC01
ATC
betamethasone, combinations; topical
2.9
6.8
42
160
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.3
6.7
33
109
S01GX02
ATC
levocabastine; ophthalmic
3.2
6.6
33
110
L04AA01
ATC
[U] ciclosporin; systemic
7.1
6.6
15
22
J37.0
ICD-10 Finland
Chronic laryngitis
5.9
6.5
17
30
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.3
6.5
23
57
R49.08
ICD-10 Finland
Other specified dysphonia
7.7
6.5
14
19
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.2
6.5
32
106
R06AE08
ATC
NA
14.7
6.4
10
7
S98
ICPC
Urticaria
14.7
6.4
10
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.1
6.4
78
424
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.4
6.4
18
35
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
11.3
6.3
11
10
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.7
6.3
26
75
3DX08
NOMESCO Finland
NA
+∞
6.3
6
*
L95.8
ICD-10 Finland
Other vasculitis limited to skin
+∞
6.3
6
*
R03BB05
ATC
aclidinium bromide; inhalant
+∞
6.3
6
*
TQX05
NOMESCO Finland
Skin puncture, unspecified location
+∞
6.3
6
*
DPW99
NOMESCO Finland
Other operation on frontal or sphenoidal sinus
27.3
6.3
8
*
WX722
NOMESCO Finland
PEEP
4.6
6.2
20
46
R01AD
ATC
Corticosteroids
8.9
6.1
12
14
D07AB01
ATC
clobetasone; topical
4.7
6.1
19
42
J01DA08
ATC
[U] cefaclor; oral
2.3
6.1
55
260

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
372
256
62.02
307.65
2.9
1.3
1100.29
228.58
u/ml
5.05
365
231
143
27
75.14
259.44
1.6
1.1
0.99
0.17
u/ml
1.71
105
11
376
1246
10.46
123.30
8.9
5.5
—
—
—
0
0
461
1970
38.68
116.77
10.5
5.6
0.61
0.55
e9/l
6.72
449
1730
461
1976
38.48
116.20
10.5
5.6
0.05
0.04
e9/l
4.14
449
1737
466
2041
52.11
114.53
11.4
5.9
0.30
0.18
e9/l
12.70
456
1819
461
2032
36.67
111.07
10.6
5.6
2.13
1.97
e9/l
0.46
450
1821
99
83
14.78
101.87
1.3
1.1
4.82
1.00
u/ml
1.07
65
31
78
42
22.00
100.79
3.0
2.9
—
—
—
0
0
93
76
14.95
97.00
1.2
1.0
3.44
10.27
u/ml
1.46
68
38
462
2289
31.42
90.94
11.1
8.8
4.30
3.99
e9/l
2.85
449
2015
85
68
14.99
89.54
1.3
1.0
4.18
4.70
u/ml
0.07
36
15
179
385
6.83
85.86
3.2
1.9
262.17
374.29
nmol/l
12.34
174
356
75
72
12.17
70.08
1.3
1.1
2.04
0.78
u/ml
0.55
51
29
134
285
6.14
63.35
4.2
4.4
0.28
0.41
%
0.35
29
64
131
274
6.21
63.01
4.6
4.7
0.03
0.03
%
0.01
30
63
65
59
12.59
62.81
1.2
1.0
10.13
3.41
u/ml
1.38
45
20
134
288
6.08
62.60
4.6
4.7
0.10
0.19
%
0.42
31
77
125
255
6.28
61.63
2.2
1.4
—
—
—
0
0
137
312
5.75
59.89
4.6
4.5
0.50
0.93
%
0.99
32
90
60
53
12.80
58.90
1.2
1.0
9.62
4.30
u/ml
1.01
44
17
130
305
5.48
54.58
2.8
2.3
9.92
10.66
g/l
1.38
124
278
50
45
12.29
48.30
1.4
1.3
2.72
2.75
g/l
0.04
39
33
50
45
12.29
48.30
1.4
1.3
0.31
0.34
g/l
0.31
39
34
50
45
12.29
48.30
1.4
1.3
—
—
—
0
0
50
45
12.29
48.30
1.4
1.3
6.09
7.50
g/l
1.28
39
34
147
425
4.55
47.29
2.5
1.6
—
—
—
0
0
177
588
4.19
47.24
1.4
1.4
336.67
485.98
titre
0.81
24
127
58
70
9.29
45.51
1.5
1.9
1.34
0.82
g/l
1.12
46
58
236
986
3.75
44.61
8.0
4.5
—
—
—
0
0
327
1758
3.72
40.40
13.6
8.2
0.00
0.00
e9/l
0.59
309
1432
53
67
8.77
39.99
3.7
4.3
57.09
56.13
%
0.16
53
67
438
2903
7.08
39.83
5.7
3.8
8.94
9.68
mm/h
0.99
429
2700
32
18
18.98
39.77
1.1
1.0
11.43
16.38
u/ml
—
14
6
51
65
8.66
38.19
3.5
3.8
4.64
4.43
e9/l
0.20
51
65
45
52
9.45
36.34
1.2
1.0
0.60
0.81
u/ml
0.11
25
11
94
244
4.55
33.93
1.5
1.6
1.04
1.45
g/l
1.62
88
225
130
428
3.80
33.88
2.2
1.4
—
—
—
0
0
48
66
7.97
33.68
1.4
1.6
—
—
—
0
0
37
5
79.79
33.35
1.0
1.0
—
—
—
0
0
133
466
3.57
31.33
2.1
1.4
—
—
—
0
0
37
41
9.70
30.74
3.7
3.0
—
—
—
0
0
416
2916
4.29
28.44
7.4
7.3
70.36
76.26
u/l
4.08
405
2748
31
30
10.98
28.29
1.1
1.0
—
—
—
0
0
67
153
4.93
28.10
1.4
1.2
—
—
—
0
0
22
14
16.42
25.54
1.1
1.1
1.51
1.06
u/ml
—
14
6
131
517
3.11
24.82
1.9
2.2
—
—
—
0
0
24
20
12.58
24.01
1.1
1.0
7.52
4.58
u/ml
—
12
6
21
16
13.68
22.10
1.4
1.3
8.56
8.36
ug/l
0.06
21
16
167
829
2.56
19.85
3.8
4.1
—
—
—
0
0
75
250
3.37
18.47
1.1
1.2
—
—
—
0
0
170
883
2.44
18.03
1.5
1.4
2.14
2.38
g/l
1.25
130
569
24
9
27.97
17.98
1.7
5.4
—
—
—
0
0
124
561
2.63
17.58
2.6
3.5
0.81
0.81
mmol/l
0.22
119
531
250
1562
2.26
16.94
2.7
2.3
77.82
75.12
nmol/l
0.78
237
1419
22
27
8.49
16.76
1.2
1.0
3.96
0.26
u/ml
—
15
6
178
971
2.33
16.65
8.5
6.7
—
—
—
0
0
160
866
2.27
14.96
2.0
1.7
0.76
1.04
mg/l
0.83
122
646
21
28
7.80
14.94
1.2
1.0
18.22
0.13
u/ml
—
13
10
19
23
8.56
14.60
1.2
2.2
14.21
11.58
%
0.38
14
12
466
4032
7.20
13.94
18.8
11.4
14.26
21.39
mg/l
6.77
421
3091
79
318
2.78
13.87
3.8
3.4
—
—
—
0
0
22
35
6.54
13.39
1.2
2.0
1.58
1.26
e9/l
0.69
16
16
28
57
5.16
13.27
4.4
3.0
—
—
—
0
0
387
3096
2.31
11.86
4.6
3.9
14.72
14.54
pmol/l
0.88
365
2863
204
1310
1.97
11.52
3.6
3.0
24.33
29.13
ng/l
0.31
125
782
203
1302
1.97
11.50
6.8
6.3
1.10
1.11
inr
0.14
80
402
344
2652
2.06
11.26
4.5
3.9
—
—
—
0
0
218
1449
1.93
10.98
3.7
4.7
36.23
36.55
g/l
0.45
207
1359
272
1947
1.92
10.91
4.8
6.4
9.24
10.92
umol/l
3.58
262
1839
27
64
4.41
10.70
5.3
2.9
8.70
9.05
kpa
0.48
27
64
27
64
4.41
10.70
5.3
2.9
2.47
2.58
mmol/l
0.08
20
41
27
64
4.41
10.70
5.3
2.9
4.90
4.95
kpa
0.13
27
64
469
4317
5.59
10.36
13.2
9.5
27.72
27.92
u/l
0.10
463
4199
240
1683
1.86
9.93
5.2
6.8
1.22
1.22
mmol/l
0.04
184
1440
222
1523
1.85
9.82
5.8
5.9
1.21
1.22
mmol/l
0.53
209
1395
54
213
2.73
9.77
2.6
2.9
72.27
76.77
e9/l
0.41
41
160
156
959
1.93
9.68
2.9
2.4
334.34
6707.42
umol/l
3.76
142
847
38
125
3.22
9.46
1.1
1.2
—
3.00
—
0
16
115
649
2.02
9.06
2.2
2.4
597.15
564.84
mosm/kgh2o
0.73
102
550
455
4053
3.55
9.05
17.6
12.6
3.88
3.95
mmol/l
7.05
449
3940
19
39
5.03
8.91
2.0
1.8
90.32
91.70
%
0.62
19
39
51
206
2.65
8.81
3.2
2.9
7.44
7.42
ph
—
10
22
155
980
1.86
8.66
1.7
1.9
—
—
—
0
0
281
2127
1.78
8.52
5.1
4.6
6.53
6.54
mmol/l
0.03
267
1969
8
0
+∞
8.35
1.1
0.0
—
—
—
0
0
40
146
2.90
8.35
1.6
1.6
—
—
—
0
0
22
54
4.22
8.35
3.2
2.4
19.01
17.07
%
—
10
23
104
582
2.01
8.33
1.3
1.6
—
—
—
0
0
96
522
2.05
8.33
1.3
1.2
—
—
—
0
0
160
1035
1.82
8.24
3.1
2.8
17.49
34.15
e6/l
1.33
133
784
452
4045
3.16
8.23
17.4
12.5
139.86
139.72
mmol/l
0.79
445
3941
425
3699
2.34
8.14
5.4
4.6
1.77
2.14
mu/l
0.60
407
3450
24
65
3.83
8.00
1.1
1.2
—
—
—
0
0
119
707
1.91
7.98
2.4
2.3
4.50
6.38
e6/l
0.78
105
624
478
4588
+∞
7.93
28.8
16.9
90.65
90.50
fl
0.34
478
4538
478
4588
+∞
7.93
28.8
16.9
30.10
30.24
pg
1.12
478
4537
70
345
2.21
7.80
1.4
1.3
100.59
169.29
iu/ml
1.04
24
144
478
4591
+∞
7.75
29.1
17.0
139.46
137.49
g/l
2.82
478
4541
192
1332
1.74
7.67
1.9
1.8
98.05
96.93
pmol/l
0.12
115
682
155
1015
1.78
7.55
3.2
3.8
7.41
7.40
ph
0.26
47
184
56
256
2.35
7.45
3.2
3.4
1.23
1.23
mmol/l
0.10
51
232
134
846
1.81
7.35
2.4
1.9
2.83
3.02
mg/l
0.49
126
727
11
7
16.04
7.26
1.5
1.1
—
—
—
0
0
11
16
7.01
7.18
2.3
1.5
—
—
—
0
0
180
1246
1.71
7.13
3.8
3.2
19.31
84.20
e6/l
1.68
140
850
169
1154
1.72
7.01
2.0
3.3
2.34
2.36
mmol/l
0.94
154
1020
252
1915
1.67
6.96
3.4
3.2
0.00
0.00
estimate
0.00
82
351
154
1028
1.73
6.92
3.5
3.4
0.00
0.01
estimate
0.69
83
359
157
1054
1.73
6.91
2.0
2.1
143.38
235.21
u/l
0.79
149
1005
151
1006
1.73
6.81
1.4
1.3
1.72
1.72
u/ml
0.00
46
295
39
157
2.62
6.79
3.1
2.9
—
—
—
0
0
20
54
3.82
6.70
1.4
1.2
—
—
—
0
0
142
935
1.74
6.66
3.0
2.7
0.30
0.43
e6/l
0.48
116
690
141
928
1.74
6.62
2.9
2.6
—
—
—
0
0
43
184
2.47
6.61
4.9
7.0
24.95
24.76
mmol/l
0.16
43
184
61
304
2.15
6.60
2.1
2.8
1.72
1.84
%
0.52
61
279
70
373
2.03
6.35
1.3
1.5
—
—
—
0
0
211
1563
1.63
6.23
2.0
2.0
—
—
—
0
0
248
1919
1.61
6.07
4.5
4.4
0.00
0.00
estimate
0.00
84
366
167
1180
1.64
5.89
2.3
2.6
52.94
55.73
u/l
0.67
150
1089
249
1938
1.59
5.88
3.5
3.2
0.04
0.02
estimate
0.21
84
350
11
20
5.61
5.83
2.0
3.4
352.91
708.50
u/ml
1.01
11
20
11
20
5.61
5.83
1.1
1.1
—
—
g/l
—
0
0
31
121
2.67
5.75
1.8
2.2
8.70
11.25
mg/l
1.97
31
112
144
986
1.66
5.72
3.7
3.2
—
—
—
0
0
9
7
13.07
5.60
1.2
1.0
—
—
—
0
0
113
736
1.70
5.38
1.3
1.3
13.45
8.87
u/ml
0.23
40
317
20
63
3.27
5.38
1.2
1.1
—
—
—
0
0
12
26
4.71
5.28
3.7
1.9
31.17
33.23
pg
0.92
12
26
96
609
1.72
5.01
3.3
3.4
18.77
553.99
ng/l
1.92
57
409
39
182
2.24
4.97
5.7
8.1
—
—
—
0
0
85
523
1.76
4.93
1.8
1.6
1233.67
1175.84
nmol/l
0.20
73
398
112
745
1.66
4.89
1.4
1.3
23.74
31.18
iu/ml
0.42
30
244
20
69
2.98
4.66
1.4
2.8
—
—
—
0
0
314
2657
1.53
4.57
3.8
3.3
—
—
—
0
0
155
1132
1.55
4.54
3.0
2.8
—
—
—
0
0
40
198
2.11
4.43
2.3
2.5
—
—
—
0
0
59
338
1.85
4.33
7.6
10.1
1.65
1.20
mmol/l
0.60
48
261
85
543
1.69
4.30
2.2
2.4
120.52
120.91
ug/g
0.00
66
423
26
108
2.49
4.30
2.2
2.9
—
—
—
0
0
227
1816
1.48
4.22
3.3
2.7
98.62
112.92
ug/l
0.37
214
1697
11
27
4.15
4.18
1.2
1.3
—
—
—
0
0
11
27
4.15
4.18
1.1
1.2
—
—
—
0
0
20
75
2.74
4.04
1.0
1.1
—
13.49
—
0
8
86
563
1.64
3.95
1.7
2.7
2.44
2.44
mmol/l
0.17
72
487
176
1365
1.46
3.72
3.0
3.6
31.09
32.36
u/l
0.23
171
1304
69
436
1.68
3.63
1.7
2.3
21.93
24.88
%
1.06
61
384
455
4297
2.22
3.60
15.4
10.7
—
—
—
0
0
105
737
1.54
3.59
1.5
1.4
21.17
21.38
nmol/l
0.06
95
628
112
798
1.53
3.58
1.4
1.7
—
—
—
0
0
26
119
2.25
3.51
1.3
1.2
—
—
—
0
0
78
519
1.60
3.35
1.8
2.2
12.63
14.32
umol/l
1.31
71
477
96
674
1.53
3.27
1.9
1.6
436.05
20069041.66
pmol/l
0.79
84
583
418
3869
1.64
3.22
17.5
12.2
41.20
40.79
%
0.46
325
3066
10
28
3.63
3.21
1.0
1.2
—
—
—
0
0
67
435
1.63
3.18
1.4
1.3
—
—
—
0
0
46
272
1.76
3.08
1.6
2.2
4.33
4.02
e9/l
0.50
40
230
31
161
1.99
3.07
9.8
14.6
—
—
—
0
0
393
3619
1.48
2.76
5.6
5.0
39.45
38.99
mmol/mol
0.38
375
3415
5
6
8.40
2.75
1.6
1.3
—
—
—
0
0
7
14
5.06
2.73
1.0
1.1
1124.86
1646.93
miu/ml
—
7
14
329
2942
1.38
2.68
3.3
3.1
41.05
43.98
u/l
0.39
313
2798
131
1015
1.40
2.65
1.8
1.7
1.32
1.45
mmol/l
0.88
107
866
13
49
2.70
2.64
1.3
1.3
0.52
0.50
nmol/l
0.07
13
43
14
56
2.55
2.55
1.1
1.1
—
—
—
0
0
10
33
3.07
2.54
1.5
3.1
—
—
—
0
0
38
226
1.74
2.52
1.1
1.1
—
106.00
—
0
5
9
26
3.51
2.49
1.8
2.2
—
—
—
0
0
69
479
1.51
2.47
1.8
2.2
2.51
2.40
g/l
0.92
63
447
64
440
1.52
2.40
2.0
2.8
4.49
8.40
umol/l
2.40
55
382
19
91
2.13
2.36
1.2
1.2
—
—
—
0
0
14
59
2.41
2.31
1.6
1.5
—
—
—
0
0
11
41
2.72
2.29
3.2
2.4
—
—
—
0
0
6
13
4.66
2.28
1.0
1.0
—
—
—
0
0
6
13
4.66
2.28
1.0
1.0
—
—
—
0
0
6
13
4.66
2.28
1.0
1.0
—
—
—
0
0
39
242
1.67
2.24
1.2
1.2
—
—
—
0
0
5
9
5.60
2.22
1.0
2.3
—
—
—
0
0
48
316
1.58
2.19
3.6
3.9
—
—
—
0
0
8
24
3.37
2.19
1.1
1.1
—
—
—
0
0
34
206
1.70
2.14
3.2
2.7
107.07
132.82
ng/l
0.18
28
186
24
132
1.86
2.07
3.8
3.7
0.14
0.17
g/l
—
7
59
8
26
3.11
2.02
1.0
1.3
—
—
—
0
0
10
38
2.67
2.02
1.2
1.4
—
—
—
0
0
9
32
2.85
2.01
1.1
1.1
—
—
—
0
0
15
71
2.15
1.94
2.9
2.4
24.11
23.74
mmol/l
0.14
15
62
36
228
1.63
1.94
1.1
1.1
—
—
—
0
0
51
352
1.50
1.91
1.2
1.2
—
—
—
0
0
7
22
3.21
1.88
1.1
1.0
—
—
—
0
0
7
22
3.21
1.88
1.0
1.8
13.34
12.65
%
—
7
22
39
254
1.58
1.88
6.9
8.6
—
—
—
0
0
64
465
1.43
1.85
1.2
1.2
—
—
—
0
0
118
952
1.32
1.80
3.5
3.3
697.25
284.55
mg/l
0.27
71
616
8
29
2.79
1.80
1.0
1.1
—
—
—
0
0
10
41
2.47
1.76
1.0
1.9
—
—
—
0
0
118
956
1.31
1.74
2.8
2.5
—
—
—
0
0
5
13
3.87
1.72
2.8
1.8
—
—
—
0
0
11
48
2.32
1.71
1.4
1.3
—
—
—
0
0
196
1699
1.26
1.69
2.5
2.6
—
—
—
0
0
10
42
2.41
1.68
1.2
1.3
—
—
nmol/l
—
0
0
409
3880
1.37
1.67
4.5
4.0
5.66
5.83
mmol/l
2.77
389
3597
5
14
3.60
1.62
1.8
1.7
0.25
1.11
ug/l
—
5
14
122
1008
1.28
1.55
4.5
4.1
6.08
10.87
mg/mmol
0.74
74
639
6
22
2.75
1.44
1.2
1.1
—
—
—
0
0
104
850
1.29
1.43
3.5
3.2
—
—
—
0
0
409
3904
1.33
1.39
4.0
3.7
1.32
1.31
mmol/l
0.04
386
3656
19
112
1.73
1.37
2.0
2.0
4.67
6.19
iu/l
—
6
39
40
285
1.44
1.32
3.8
3.2
—
—
—
0
0
130
1102
1.25
1.32
3.5
3.2
8.12
8.22
mmol/l
0.09
114
933
425
4087
1.36
1.31
4.8
4.4
2.95
2.89
mmol/l
0.88
405
3827
421
4045
1.34
1.29
4.6
4.1
4.91
4.79
mmol/l
1.66
401
3814
5
18
2.80
1.29
1.2
1.2
—
—
—
0
0
5
18
2.80
1.29
1.0
1.3
—
—
—
0
0
12
63
1.93
1.23
3.0
2.4
9.23
8.41
kpa
0.93
12
58
30
206
1.49
1.21
1.5
2.3
2956.50
2672.77
u/l
—
6
91
12
64
1.90
1.19
1.8
1.8
—
—
—
0
0
8
40
2.02
1.12
1.6
1.7
—
—
—
0
0
8
40
2.02
1.12
1.6
1.7
—
—
—
0
0
8
40
2.02
1.12
1.6
1.7
—
—
—
0
0
8
40
2.02
1.12
1.6
1.7
—
—
—
0
0
36
261
1.41
1.11
2.2
3.4
2.86
2.26
mmol/l
0.35
30
214
14
81
1.75
1.10
1.0
1.2
—
—
—
0
0
65
519
1.29
1.09
3.2
2.6
3.56
2.74
e6/l
0.34
34
267
11
59
1.88
1.08
1.9
3.3
—
—
—
0
0
418
4032
1.29
1.07
4.4
4.0
1.53
1.47
mmol/l
1.93
398
3780
6
121
0.49
1.06
1.7
1.4
—
—
—
0
0
7
34
2.07
1.03
1.3
1.2
275.14
280.08
mosm/kgh2o
—
7
26
48
373
1.32
0.99
13.4
15.1
1.40
1.23
inr
—
7
57
45
347
1.33
0.98
2.5
2.4
54.11
32.07
u/l
0.52
36
292
7
36
1.96
0.97
2.3
3.2
—
—
—
0
0
6
120
0.49
0.94
1.7
1.4
—
—
—
0
0
6
28
2.16
0.92
2.5
3.4
—
—
—
0
0
6
28
2.16
0.92
2.7
1.2
—
—
—
0
0
13
79
1.66
0.89
1.0
1.1
—
—
—
0
0
16
105
1.54
0.82
2.2
2.2
—
—
—
0
0
24
172
1.42
0.82
2.0
1.6
—
—
—
0
0
12
73
1.66
0.82
2.8
1.7
—
—
—
0
0
12
73
1.66
0.82
2.6
4.4
—
—
—
0
0
109
955
1.18
0.80
3.9
3.9
1.35
2.01
ug/l
1.10
99
870
15
98
1.55
0.79
1.2
1.1
—
—
—
0
0
15
98
1.55
0.79
1.2
1.1
—
—
—
0
0
7
123
0.56
0.79
1.6
1.5
—
—
—
0
0
7
125
0.55
0.78
26.3
8.8
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
—
—
0
0
34
262
1.32
0.77
2.8
8.0
8.66
7.80
mmol/l
0.34
34
250
18
124
1.47
0.76
1.1
1.1
—
—
—
0
0
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
49
587
0.82
0.66
1.3
1.3
—
—
—
0
0
16
112
1.44
0.64
1.1
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
8
52
1.55
0.59
1.4
1.4
—
—
—
0
0
17
230
0.73
0.58
1.3
2.8
14.71
43.20
u/ml
1.83
17
223
6
35
1.72
0.58
1.7
3.1
1.83
2.95
nmol/l
—
6
35
6
35
1.72
0.58
3.7
2.7
—
—
—
0
0
10
65
1.55
0.56
1.3
1.8
13.40
13.06
%
—
10
65
10
65
1.55
0.56
1.6
1.3
—
—
—
0
0
66
576
1.17
0.53
2.4
2.5
0.48
0.66
ug/l
2.75
39
329
24
190
1.28
0.49
1.4
1.3
157.42
253.08
miu/ml
—
9
100
7
46
1.53
0.48
1.3
1.1
—
—
—
0
0
7
47
1.50
0.47
2.6
2.2
—
—
—
0
0
26
319
0.80
0.46
2.6
4.4
2.94
6.95
ug/l
1.65
19
258
21
166
1.28
0.44
2.2
2.2
—
—
—
0
0
110
1195
0.90
0.44
1.5
1.5
—
—
—
0
0
14
104
1.36
0.43
1.1
1.1
—
—
—
0
0
36
304
1.20
0.43
1.3
1.4
—
—
—
0
0
5
31
1.62
0.43
1.2
2.8
25.80
19.77
mu/l
—
5
31
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
5.6
—
—
—
0
0
16
123
1.31
0.41
9.8
4.8
—
—
—
0
0
0
17
0.00
0.40
0.0
23.3
—
7.02
—
0
12
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
15
115
1.31
0.39
1.2
2.9
1.08
1.37
mg/l
2.04
15
106
60
536
1.14
0.38
1.6
1.4
—
—
—
0
0
10
72
1.40
0.37
1.1
1.0
—
—
—
0
0
5
79
0.63
0.35
4.0
3.7
—
—
—
0
0
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
20
164
1.23
0.33
1.2
1.3
—
—
—
0
0
22
185
1.20
0.29
2.5
2.4
0.08
0.11
e6/l
0.26
22
179
8
65
1.23
0.27
2.9
1.9
—
—
—
0
0
16
132
1.22
0.26
1.5
1.3
—
—
—
0
0
56
513
1.10
0.25
1.6
1.7
—
—
—
0
0
112
1182
0.93
0.25
2.0
2.1
—
—
—
0
0
31
346
0.89
0.22
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
0.73
—
0
8
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
28
311
0.89
0.19
2.0
1.7
—
—
—
0
0
23
204
1.13
0.18
1.1
1.1
—
—
—
0
0
8
72
1.11
0.16
1.3
1.2
—
—
—
0
0
59
557
1.07
0.15
1.6
1.7
—
—
—
0
0
185
1810
1.04
0.12
3.4
3.9
—
—
—
0
0
26
240
1.09
0.11
2.2
2.3
2.35
7.91
ug/l
3.88
26
218
24
222
1.09
0.10
3.1
2.2
—
—
—
0
0
12
106
1.14
0.10
1.1
1.4
363.86
308.65
ug/g
—
7
62
22
236
0.93
0.08
4.5
1.7
—
—
—
0
0
10
88
1.14
0.08
1.1
1.3
—
—
—
0
0
8
76
1.05
0.07
1.0
1.3
—
—
—
0
0
20
188
1.07
0.05
5.3
1.8
—
—
—
0
0
23
219
1.05
0.04
4.1
1.9
—
—
—
0
0
15
160
0.94
0.04
3.6
2.8
—
—
—
0
0
85
862
0.98
0.03
3.1
3.3
1.02
1.02
kg/l
—
8
108
23
239
0.96
0.02
4.5
1.8
—
—
—
0
0
23
237
0.97
0.01
4.1
1.8
—
—
—
0
0
11
104
1.06
0.01
6.9
2.3
—
—
—
0
0
23
236
0.97
0.00
4.7
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
15.37
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
1.85
—
0
9
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
1.20
—
0
9
0
8
0.00
0.00
0.0
2.5
—
6852.62
—
0
8
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
16
160
1.00
0.00
2.7
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
54.96
—
0
7

Mortality – FinRegistry

Association

Association between endpoint RX_ASTMA_BIOL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have RX_ASTMA_BIOL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: RX_ASTMA_BIOL – Biological medicines for asthma

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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