No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D01
- Name in latin
- Carcinoma in situ ani
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of colon
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of colon
- Carcinoma in situ of other and unspecified digestive organs
- Carcinoma in situ of other and unspecified digestive organs
- In situ neoplasms
- In situ neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 244 | 110 | 126 |
| Only index persons | 137 | 74 | 63 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 69.31 | 68.60 | 70.00 |
| Only index persons | 65.02 | 64.98 | 65.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 438 | 175 | 263 |
| Unadjusted period prevalence (%) | 0.09 | 0.06 | 0.12 |
| Median age at first event (years) | 71.38 | 71.88 | 71.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 393
- Matched controls
- 3930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJF32
NOMESCO Finland
Coloscopy
10.4
96.4
262
635
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
158.0
64.1
66
5
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
15.6
62.2
107
92
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
17.7
61.0
99
73
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
22.6
58.3
86
48
130
Kela drug reimbursment
Malignant tumour
+∞
57.7
54
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
13.0
55.6
104
106
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
21.3
54.5
82
48
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
10.1
47.4
101
130
WX302
NOMESCO Finland
Thoracal epidural anesthesy
22.4
45.0
66
35
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
31.3
44.4
59
22
8263/2-C18.0
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of cecum
+∞
43.5
41
*
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
43.5
43.1
53
14
WX402
NOMESCO Finland
General anaesthesia
6.4
42.7
128
274
C187, 8211, 2
ICD-O-3
NA
+∞
42.5
40
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
39.2
37
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
39.2
37
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
215.7
38.5
39
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
11.9
34.4
65
64
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
18.4
34.0
53
33
L01BC06
ATC
capecitabine; oral
+∞
33.8
32
*
B01AB05
ATC
enoxaparin; parenteral
3.9
32.1
179
695
8263/2-C18.7
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of sigmoid colon
+∞
31.7
30
*
C189, 8211, 2
ICD-O-3
NA
+∞
31.7
30
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
31.7
30
*
K63.5
ICD-10 Finland
Polyp of colon
32.5
31.4
41
14
A04AA02
ATC
granisetron; systemic, transdermal
338.3
31.3
31
*
JN4AD
NOMESCO Finland
Body CT examination
12.9
31.0
56
50
JN4BD
NOMESCO Finland
Extensive body CT
8.0
28.6
68
100
WF002
NOMESCO Finland
Radical radiotherapy
156.0
28.0
29
*
H02AB02
ATC
dexamethasone; systemic
25.3
28.0
39
17
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
15.4
26.0
43
31
116
Kela drug reimbursment
Prostate cancer
+∞
25.3
24
*
C180, 8211, 2
ICD-O-3
NA
+∞
25.3
24
*
8263/2-C18.9
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of colon, NOS
+∞
25.3
24
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
25.3
24
*
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
8.6
24.3
54
71
B01AB10
ATC
tinzaparin; parenteral
7.8
23.5
56
82
C18.71
ICD-10 Finland
Malignant tumor of the sigmoid invasive carcinoma
+∞
22.1
21
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.7
21.7
80
203
C187, 8148, 2
ICD-O-3
NA
+∞
21.0
20
*
C18.70
ICD-10 Finland
Malignant tumor of the sigmoid without histology
+∞
21.0
20
*
UJF30
NOMESCO Finland
Ileoscopy through colon
4.8
20.0
71
172
C189, 8148, 2
ICD-O-3
NA
+∞
18.9
18
*
UJF32
SPAT
NA
11.9
18.6
34
31
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.2
18.0
34
33
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
99.6
17.7
19
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
188.0
17.7
18
*
L02AE02
ATC
leuprorelin; implant, parenteral
66.3
16.9
19
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.0
16.8
118
495
D01.0
ICD-10 Finland
Carcinoma in situ: Colon
+∞
16.8
16
*
C180, 8148, 2
ICD-O-3
NA
+∞
16.8
16
*
8211/2-C18.2
ICD-O-3
Tubular adenocarcinoma in situ of ascending colon
+∞
16.8
16
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.0
16.8
73
214
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
94.1
16.7
18
*
WX600
NOMESCO Finland
Single shot through catheter
177.1
16.6
17
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.9
15.8
45
84
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
15.7
15
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
15.7
15
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
15.7
15
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
15.7
145
718
JFA15
SPAT
NA
30.0
15.3
20
7
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
8.1
14.7
33
44
C18.72
ICD-10 Finland
Malignant tumor of sigmoid carcinoma of adenoma
+∞
14.7
14
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
14.7
14
*
8263/2-C18.2
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of ascending colon
+∞
14.7
14
*
Z51.5
ICD-10 Finland
Palliative care
9.6
14.0
28
31
C18.20
ICD-10 Finland
Malignant tumor of the ascending colon without histology
+∞
13.6
13
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
13.6
13
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
13.6
13
*
JFB44
NOMESCO Finland
Laparoscopic left hemicolectomy
144.7
13.5
14
*
C18.00
ICD-10 Finland
Malignant tumor of the caecum without histology
144.7
13.5
14
*
WZC30
NOMESCO Finland
Teaching
3.8
13.4
60
179
D12.7
ICD-10 Finland
Benign neoplasm: Rectosigmoid junction
15.8
13.2
21
14
R4110
NOMESCO Finland
Physiotherapy
2.5
12.6
123
613
JGB03
NOMESCO Finland
Partial proctectomy with partial excision of mesorectum
+∞
12.6
12
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
12.6
12
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
12.6
12
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.5
12.5
121
599
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
134.0
12.5
13
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.0
11.9
48
131
8140/2-C18.7
ICD-O-3
Adenocarcinoma in situ, NOS, of sigmoid colon
+∞
11.5
11
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
11.4
62
214
JFB30
NOMESCO Finland
Right hemicolectomy
20.8
11.2
16
8
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
10.9
69
264
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
61.7
10.7
12
*
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
61.7
10.7
12
*
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
4.9
10.5
34
75
Y77
ICPC
Malignant neoplasm prostate
112.9
10.5
11
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
10.5
10
*
L02BB03
ATC
bicalutamide; oral
+∞
10.5
10
*
C18.01
ICD-10 Finland
Malignant tumor of the caecum invasive carcinoma
+∞
10.5
10
*
8140/3-C18.7
ICD-O-3
Adenocarcinoma, NOS, of sigmoid colon
+∞
10.5
10
*
115
Kela drug reimbursment
Breast cancer
+∞
10.5
10
*
8140/3-C19.9
ICD-O-3
Adenocarcinoma, NOS, of rectosigmoid junction
+∞
10.5
10
*
A04AA01
ATC
ondansetron; systemic, rectal
8.6
10.5
22
27
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
10.1
35
83
JFF23
NOMESCO Finland
Transversostomy
56.4
9.7
11
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
56.4
9.7
11
*
JFA52
NOMESCO Finland
Other endoscopic haemostatic procedure in colon
56.4
9.7
11
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
9.6
41
118
JFB47
NOMESCO Finland
Laparoscopic resection of sigmoid colon
18.1
9.5
14
8
WF049
NOMESCO Finland
Radiotherapy of metastasis
102.4
9.5
10
*
C188, 8211, 2
ICD-O-3
NA
+∞
9.4
9
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
9.4
9
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
9.4
9
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
9.4
9
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
9.4
9
*
JG1CG
NOMESCO Finland
Extensive MRI of rectum
+∞
9.4
9
*
C18.21
ICD-10 Finland
Malignant tumor of the ascending colon invasive carcinoma
+∞
9.4
9
*
C186, 8211, 2
ICD-O-3
NA
+∞
9.4
9
*
C20
ICD-10 Finland
Malignant neoplasm of rectum
+∞
9.4
9
*
C184, 8148, 2
ICD-O-3
NA
+∞
9.4
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.4
9
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
9.4
9
*
C184, 8211, 2
ICD-O-3
NA
+∞
9.4
9
*
N02BE01
ATC
paracetamol; systemic, rectal
2.4
9.4
342
2880
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
9.3
183
1210
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
9.0
83
393
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
8.8
100
523
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
8.8
135
805
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
5.4
8.6
25
49
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
8.5
96
501
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
8.4
8
*
JFB51
NOMESCO Finland
Other laparoscopic resection of colon
+∞
8.4
8
*
L02BG04
ATC
letrozole; oral
+∞
8.4
8
*
C182, 8148, 2
ICD-O-3
NA
+∞
8.4
8
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
ZXE00
NOMESCO Finland
One hour or less
1.9
8.2
154
984
C03CA01
ATC
furosemide; systemic
2.0
8.2
137
838
L03AA02
ATC
filgrastim; parenteral
34.1
8.1
10
*
Z2221
NOMESCO Finland
Medical doctor
2.1
7.9
107
603
A02BC02
ATC
pantoprazole; systemic
1.8
7.8
254
1956
D75
ICPC
Malignant neoplasm colon/rectum
45.9
7.7
9
*
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
45.9
7.7
9
*
JAH01
NOMESCO Finland
Laparoscopy
6.9
7.7
18
27
Z3231
NOMESCO Finland
Registered nurse
2.0
7.7
115
674
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
4.6
7.6
25
57
UJD10
SPAT
NA
10.3
7.6
14
14
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.6
148
956
WX110
NOMESCO Finland
Local anesthesy
1.8
7.5
248
1906
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
5.8
7.5
20
36
JGB06
NOMESCO Finland
Partial proctectomy with total excision of mesorectum
81.5
7.4
8
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
7.3
7
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
7.3
7
*
L02BA01
ATC
tamoxifen; oral
+∞
7.3
7
*
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
+∞
7.3
7
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
7.3
7
*
8140/3-C18.9
ICD-O-3
Adenocarcinoma, NOS, of colon, NOS
+∞
7.3
7
*
TQW40
NOMESCO Finland
Remowal of suture of skin
3.3
7.2
34
108
Z01.9
ICD-10 Finland
Special examination, unspecified
3.6
6.7
28
81
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.8
6.5
20
43
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
70.9
6.4
7
*
D50
ICD-10 Finland
Iron deficiency anaemia
9.5
6.3
12
13
WX892
NOMESCO Finland
Monitored bed care
2.8
6.3
40
154
C90.0
ICD-10 Finland
Multiple myeloma
+∞
6.3
6
*
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
+∞
6.3
6
*
8140/3-C18.0
ICD-O-3
Adenocarcinoma, NOS, of cecum
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.3
6
*
8263/2-C18.4
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of transverse colon
+∞
6.3
6
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
C19
ICD-10 Finland
Malignant neoplasm of rectosigmoid junction
+∞
6.3
6
*
C18.79
ICD-10 Finland
Malignant tumor of the sigmoid or other unspecified histology
+∞
6.3
6
*
JN4CD
NOMESCO Finland
Very extensive body CT
5.9
6.2
16
28
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.9
6.2
24
65
XKD00
NOMESCO Finland
Uroflowmetry
2.1
6.2
71
370
R18
ICD-10 Finland
Ascites
10.2
6.1
11
11
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
10.2
6.1
11
11
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_COLON_EXALLC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have CD2_INSITU_COLON_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_COLON_EXALLC – Carcinoma in situ of colon
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data