sebaceous gland disease: A skin disease that is located_in the sebaceous gland.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
526 |
4. Check minimum number of eventsNone |
526 |
5. Include endpointsNone |
526 |
6. Filter based on genotype QC (FinnGen only) |
526 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acne
based on the number of shared cases.
Similar with more cases:
- Acne
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4278 | 2091 | 2170 |
| Only index persons | 4081 | 2024 | 2057 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.08 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 23.04 | 26.01 | 20.09 |
| Only index persons | 22.92 | 25.91 | 19.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 526 | 322 | 204 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.09 |
| Median age at first event (years) | 26.87 | 28.23 | 24.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 462
- Matched controls
- 4621
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.9
ICD-10 Finland
Acne, unspecified
340.8
270.7
251
16
L70.8
ICD-10 Finland
Other acne
1434.6
197.0
178
*
D10BA01
ATC
isotretinoin; oral
14.0
102.7
195
228
L70.0
ICD-10 Finland
Acne vulgaris
28.6
98.7
137
67
J01AA07
ATC
tetracycline; systemic
7.2
69.1
202
447
J01AA04
ATC
lymecycline; systemic
7.2
63.1
180
376
L73.2
ICD-10 Finland
Hidradenitis suppurativa
125.9
33.2
35
*
G03HB01
ATC
cyproterone and estrogen; systemic
4.8
32.3
122
321
D10AX03
ATC
azelaic acid; topical
4.9
30.0
109
274
70612
ICD-8 Finland
Diseases of sebaceous glands, Acne alia sive NUD
+∞
26.3
25
*
L70.1
ICD-10 Finland
Acne conglobata
74.2
25.1
28
*
L70
ICD-10 Finland
Acne
8.9
23.1
50
62
L71.9
ICD-10 Finland
Rosacea, unspecified
19.6
22.1
33
18
L73.8
ICD-10 Finland
Other specified follicular disorders
32.9
19.5
25
8
E000001
ATC
NA
2.9
19.2
138
584
D06BX01
ATC
metronidazole; topical
4.3
19.0
74
194
L71.8
ICD-10 Finland
Other rosacea
73.0
18.9
21
*
E0000UV
ATC
NA
2.5
18.6
225
1283
E0001A1
ATC
NA
7.0
16.9
42
65
D10AF01
ATC
clindamycin; topical
5.1
15.3
49
105
S96
ICPC
Acne
6.8
14.0
35
55
L72.1
ICD-10 Finland
Trichilemmal cyst
6.1
13.9
38
67
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
13.9
100
416
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
12.8
50
131
UJF32
NOMESCO Finland
Coloscopy
2.7
12.8
96
407
L04AX01
ATC
azathioprine; systemic
5.2
12.3
38
78
SPAT1301
SPAT
No procedures
2.2
11.9
154
858
J01FF01
ATC
clindamycin; systemic
2.3
11.9
127
646
H02AB06
ATC
prednisolone; systemic
2.1
11.7
192
1184
J01DB01
ATC
cefalexin; oral
2.3
11.5
383
3134
SPAT1310
SPAT
Counselling related to known health issue
2.1
11.0
167
990
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
10.3
153
894
137
Kela drug reimbursment
Uraemia requiring dialysis
17.2
9.9
15
9
TQW80
NOMESCO Finland
Local dermatologic skincare
6.9
9.5
23
35
D07AD01
ATC
clobetasol; topical
2.7
9.4
68
279
L71
ICD-10 Finland
Rosacea
7.7
9.0
20
27
N02BE01
ATC
paracetamol; systemic, rectal
2.0
8.9
367
3044
A02BC02
ATC
pantoprazole; systemic
1.8
8.8
242
1746
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
8.6
200
1359
B05DA
ATC
Isotonic solutions
16.7
8.6
13
8
A02BC05
ATC
esomeprazole; systemic
1.9
8.5
149
918
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.5
8.5
29
68
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
8.1
8.4
18
23
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
8.4
89
447
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
8.3
162
1036
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.8
8.2
18
24
L04AA06
ATC
mycophenolic acid; systemic
7.8
8.2
18
24
Z49.2
ICD-10 Finland
Other dialysis
17.6
8.1
12
7
B05DB
ATC
Hypertonic solutions
17.6
8.1
12
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
8.1
64
279
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
7.9
103
566
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.9
7.8
46
169
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
15.3
7.7
12
8
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.9
7.7
24
51
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.6
7.7
17
23
S10
ICPC
Boil/carbuncle
3.5
7.5
33
98
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
4.2
7.4
27
68
N06AX11
ATC
mirtazapine; oral
1.9
7.3
128
786
N03AX16
ATC
pregabalin; oral
2.1
7.2
83
428
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
7.2
93
508
J04BA02
ATC
dapsone; oral
20.4
7.2
10
5
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.1
7.1
26
66
L04AA01
ATC
[U] ciclosporin; systemic
9.0
7.1
14
16
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.2
7.1
16
23
D07AC01
ATC
betamethasone; topical
1.8
7.0
135
849
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
7.0
126
774
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
7.0
32
98
XQ848
NOMESCO Finland
Dermatological photography
6.5
7.0
17
27
A02BC01
ATC
omeprazole; systemic
2.0
6.9
98
555
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
6.9
57
254
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
3.3
6.9
33
105
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.9
141
906
SPAT1263
SPAT
Sampling
1.7
6.9
202
1451
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.9
6.8
26
69
N18.8
ICD-10 Finland
Other chronic renal failure
7.3
6.8
15
21
127
Kela drug reimbursment
Transplant complication
6.6
6.7
16
25
SPAT1153
SPAT
Removal of sutures
1.9
6.6
112
673
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.2
6.6
12
12
A11CC03
ATC
alfacalcidol; systemic
6.3
6.5
16
26
L04AD01
ATC
ciclosporin; systemic
5.8
6.5
17
30
N03AX12
ATC
gabapentin; oral
2.4
6.5
54
242
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.5
133
852
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
7.6
6.5
14
19
Z94.0
ICD-10 Finland
Kidney transplant status
8.3
6.4
13
16
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.3
88
490
V03AE01
ATC
polystyrene sulfonate; oral
9.4
6.3
12
13
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
+∞
6.3
6
*
7061X
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE ALIA DEFINITA]
+∞
6.3
6
*
70600
ICD-8 Finland
Diseases of sebaceous glands, Acne necrotica
+∞
6.3
6
*
70610
ICD-8 Finland
Diseases of sebaceous glands, Acne vulgaris
+∞
6.3
6
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.2
6.3
14
20
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.6
6.2
26
75
J01MA12
ATC
levofloxacin; systemic
2.2
6.2
62
303
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.2
6.2
64
318
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.7
6.1
25
71
A12AA04
ATC
calcium carbonate; oral
8.8
6.1
12
14
E000002
ATC
NA
2.2
6.1
65
326
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.1
69
354
TK800
NOMESCO Finland
Hemodialysis
5.3
6.1
17
33
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.2
6.0
15
25
K30
ICD-10 Finland
Functional dyspepsia
2.5
6.0
46
198
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
370
2808
2.07
12.89
11.4
6.3
73.0
73.3
u/l
0.05
339
2641
182
1085
2.04
12.65
3.9
2.5
56.7
55.0
u/l
0.27
167
1001
99
465
2.39
12.48
4.7
2.2
13.4
14.8
umol/l
1.22
94
431
256
1764
1.88
11.27
7.1
5.5
9.1
10.5
umol/l
2.62
239
1662
371
2883
1.97
11.24
5.6
3.5
9.6
8.5
mm/h
0.97
348
2678
205
1317
1.91
11.19
9.5
4.6
36.9
37.3
g/l
0.55
196
1253
285
2040
1.87
11.05
10.4
5.6
28.1
29.8
%
2.24
273
1929
95
465
2.27
10.81
2.0
1.8
—
—
—
0
0
152
896
1.98
10.61
2.9
1.9
2.7
2.8
mg/l
0.16
135
769
289
2095
1.84
10.59
6.7
4.4
6.4
6.4
mmol/l
0.06
270
1863
30
78
4.02
10.53
5.4
3.9
55.4
56.1
%
0.10
30
78
94
464
2.25
10.46
1.9
1.7
1321.2
1197.0
nmol/l
0.65
67
355
314
2344
1.84
10.37
14.1
8.0
4.2
4.0
e9/l
1.19
292
2047
206
1355
1.86
10.25
11.3
5.4
1.2
1.2
mmol/l
0.30
187
1228
219
1509
1.77
9.07
12.7
5.8
1.2
1.2
mmol/l
0.01
184
1275
184
1208
1.80
8.96
1.9
1.7
95.3
97.6
pmol/l
0.28
102
630
222
1547
1.75
8.77
3.4
2.3
74.8
71.5
nmol/l
0.82
211
1429
79
391
2.20
8.67
5.7
2.2
23.5
25.2
%
0.49
73
344
14
23
6.23
8.22
1.0
1.0
1367.3
1700.9
miu/ml
0.57
14
23
495
4492
2.73
7.30
14.7
7.8
26.6
27.1
u/l
0.21
484
4344
194
1355
1.68
7.28
4.1
3.1
29.4
29.4
u/l
0.01
184
1285
64
312
2.20
7.27
1.7
1.7
—
—
—
0
0
56
260
2.29
7.15
9.4
3.8
1.5
2.0
mmol/l
0.74
47
205
19
47
4.16
7.14
1.3
1.2
—
—
—
0
0
391
3283
1.74
7.10
4.6
3.8
14.7
14.5
pmol/l
1.22
355
3019
88
494
1.94
6.84
7.9
3.8
0.8
0.8
mmol/l
1.63
82
463
63
316
2.13
6.66
2.0
1.7
—
—
—
0
0
156
1051
1.69
6.59
4.2
2.7
2.3
2.4
mmol/l
1.27
141
950
16
37
4.43
6.53
1.6
2.1
—
—
—
0
0
78
428
1.97
6.47
3.3
2.3
6005.2
4486.6
u/l
0.16
28
188
100
596
1.84
6.45
3.9
3.1
1555.6
664.4
ng/l
1.52
77
464
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
71
3.34
6.35
6.6
4.7
0.3
0.3
u/ml
0.10
13
39
35
138
2.65
6.33
2.0
1.7
0.0
0.0
iu/ml
—
6
26
35
141
2.59
6.08
4.0
3.2
3.3
3.5
g/l
0.50
35
136
164
1141
1.64
6.04
3.8
2.9
38.3
42.1
ng/l
0.06
84
548
428
3761
1.74
5.75
4.5
3.1
1.3
1.2
mmol/l
1.64
405
3539
360
3029
1.60
5.74
3.3
2.8
42.3
35.5
u/l
0.91
343
2888
273
2161
1.55
5.68
4.5
2.7
98.6
77.0
ug/l
1.57
255
2016
16
42
3.90
5.57
1.8
1.9
—
—
—
0
0
18
52
3.55
5.50
1.2
1.2
—
—
—
0
0
316
2601
1.54
5.38
5.6
3.7
437.8
172.4
e6/l
—
5
29
9
8
11.42
5.30
6.6
5.9
—
—
—
0
0
18
55
3.35
5.07
1.6
1.8
—
—
—
0
0
31
129
2.49
5.07
1.5
1.2
—
—
—
0
0
441
3948
1.72
5.03
4.9
3.4
4.6
4.7
mmol/l
0.35
419
3729
62
343
1.92
5.01
2.8
2.1
11.2
13.3
nmol/l
1.07
54
319
22
77
2.94
4.98
1.7
1.7
—
—
—
0
0
30
124
2.51
4.97
1.5
1.2
217.8
220.2
u/ml
0.02
24
79
450
4063
1.74
4.83
20.0
10.1
4.0
3.9
mmol/l
1.62
433
3918
16
47
3.48
4.78
1.3
1.6
—
—
—
0
0
16
47
3.48
4.78
1.6
1.6
—
—
—
0
0
98
631
1.68
4.77
1.7
1.6
417.7
24416948.5
pmol/l
0.80
84
557
432
3869
1.65
4.65
5.4
4.4
1.7
2.4
mu/l
0.91
404
3626
448
4051
1.71
4.64
19.4
10.0
139.4
139.6
mmol/l
1.42
436
3919
39
188
2.16
4.59
8.5
3.0
0.4
1.4
mmol/l
0.67
31
131
114
772
1.61
4.54
6.6
4.3
21.6
12.0
mg/mmol
0.43
81
505
25
100
2.57
4.44
1.8
1.5
114.9
112.4
u/ml
—
7
17
253
2039
1.46
4.43
4.7
3.0
0.0
0.0
estimate
0.00
63
423
29
125
2.40
4.42
1.9
2.0
—
—
—
0
0
28
119
2.43
4.40
1.9
1.9
—
—
—
0
0
22
83
2.72
4.38
2.8
1.6
—
—
—
0
0
16
51
3.20
4.24
1.9
2.0
—
—
—
0
0
16
51
3.20
4.24
1.1
1.5
—
—
—
0
0
13
36
3.68
4.23
1.6
1.8
—
—
—
0
0
127
898
1.55
4.18
2.4
2.2
121.5
267.3
u/l
1.29
119
853
467
4302
1.76
4.12
20.2
9.9
18.9
20.2
mg/l
0.41
390
3254
21
80
2.69
4.11
1.7
1.7
—
—
—
0
0
39
197
2.06
4.09
2.2
1.6
—
—
—
0
0
251
2048
1.43
3.98
5.9
4.2
0.0
0.0
estimate
0.50
67
436
97
653
1.60
3.94
1.6
1.3
19.7
19.6
nmol/l
0.01
85
568
32
152
2.18
3.93
3.4
2.7
152.6
96.3
ng/l
0.46
25
133
131
950
1.50
3.81
5.5
2.6
0.3
0.3
e6/l
0.14
104
687
418
3769
1.53
3.79
4.1
3.3
5.8
5.7
mmol/l
0.85
381
3491
252
2074
1.41
3.73
4.7
3.1
0.0
0.0
estimate
0.00
63
416
12
35
3.49
3.64
1.3
1.5
—
—
—
0
0
115
819
1.52
3.63
3.7
2.4
2999.5
3513.5
umol/l
0.07
98
746
18
68
2.71
3.60
4.1
2.7
23.8
24.2
mmol/l
0.10
18
55
83
551
1.60
3.56
3.4
3.1
473.5
557.8
ng/l
0.09
46
325
232
1893
1.40
3.56
4.8
4.1
—
—
—
0
0
54
320
1.77
3.54
3.1
2.8
—
—
—
0
0
159
1215
1.44
3.51
6.3
2.8
—
—
—
0
0
380
3381
1.45
3.50
6.0
4.3
38.3
38.0
mmol/mol
0.26
357
3200
146
1101
1.45
3.45
5.8
3.2
0.0
0.0
estimate
1.08
65
426
16
58
2.81
3.45
1.2
1.7
—
—
—
0
0
29
140
2.13
3.44
1.7
1.5
—
—
—
0
0
10
27
3.76
3.37
1.0
1.2
—
—
—
0
0
204
1640
1.40
3.36
4.8
3.0
—
—
—
0
0
19
77
2.52
3.33
3.5
2.7
—
—
—
0
0
17
66
2.63
3.24
1.5
1.2
—
—
—
0
0
36
193
1.93
3.24
1.8
1.4
—
—
—
0
0
11
33
3.38
3.21
1.5
1.2
—
—
—
0
0
429
3930
1.50
3.20
4.6
3.4
1.4
1.4
mmol/l
0.22
406
3696
19
79
2.46
3.17
10.5
3.3
9.4
8.9
kpa
0.77
19
71
122
904
1.46
3.14
3.2
2.0
—
—
—
0
0
12
39
3.13
3.11
1.3
1.9
—
—
—
0
0
121
898
1.45
3.08
2.8
1.9
1.0
0.9
mg/l
0.11
92
644
14
51
2.79
3.00
3.4
2.5
17.0
17.0
%
—
8
20
17
69
2.51
2.99
12.4
2.6
5.2
4.9
kpa
0.96
17
69
431
3976
1.47
2.87
4.7
3.6
2.8
2.8
mmol/l
0.87
405
3725
21
96
2.24
2.87
1.0
1.1
—
—
—
0
0
64
421
1.59
2.87
2.6
3.0
5.3
6.9
umol/l
0.75
55
354
27
137
2.02
2.85
3.6
2.2
—
—
—
0
0
40
236
1.75
2.70
9.9
2.9
1.2
1.2
mmol/l
0.11
35
202
8
19
4.26
2.68
5.7
2.1
—
—
—
0
0
46
284
1.68
2.65
2.9
3.6
4.6
4.7
pmol/l
0.17
41
257
148
1172
1.37
2.56
1.4
1.3
0.8
1.8
u/ml
1.78
45
322
26
136
1.96
2.55
1.5
1.3
—
—
—
0
0
121
928
1.39
2.55
2.4
1.6
1.5
1.4
mmol/l
0.32
107
804
23
115
2.05
2.55
7.0
2.9
25.1
24.8
mmol/l
0.17
23
109
17
77
2.25
2.40
1.4
1.2
—
—
—
0
0
166
1358
1.32
2.29
1.9
1.7
—
—
—
0
0
8
23
3.52
2.27
1.1
1.7
—
—
—
0
0
8
24
3.37
2.18
1.8
2.6
1634.0
614.0
u/ml
—
8
24
16
74
2.20
2.16
1.3
1.4
—
—
—
0
0
413
3839
1.35
2.14
15.6
8.5
94.1
95.5
ml/min/173m2
0.55
345
2998
39
246
1.63
2.11
10.5
8.9
120.5
124.6
g/l
0.52
39
233
18
89
2.06
2.08
1.6
1.2
4.0
4.3
u/ml
—
8
35
7
20
3.53
2.06
2.7
2.1
30.1
26.5
umol/l
—
7
20
10
38
2.66
2.02
2.0
1.5
—
—
—
0
0
47
314
1.55
2.01
2.3
1.8
—
—
—
0
0
15
70
2.18
2.00
1.3
1.1
—
—
—
0
0
51
348
1.52
1.99
5.3
5.0
—
—
—
0
0
19
98
1.97
1.97
2.3
2.2
9.0
11.2
mg/l
0.73
19
93
11
45
2.48
1.94
1.7
1.1
161.3
256.0
mg/l
1.49
11
39
6
16
3.78
1.94
1.3
1.1
—
—
—
0
0
6
16
3.78
1.94
1.3
1.1
75.3
95.6
%
—
6
16
9
33
2.76
1.94
1.1
1.1
—
—
—
0
0
16
78
2.08
1.93
1.3
1.3
—
1.4
—
0
8
18
92
1.99
1.92
1.7
1.2
2.0
5.6
u/ml
—
10
30
11
46
2.42
1.86
1.9
1.2
23.6
42.5
mg/l
1.25
11
34
88
677
1.36
1.81
1.3
1.3
13.6
26.2
iu/ml
1.82
20
209
67
493
1.41
1.80
3.0
2.5
2.4
2.4
mmol/l
0.03
60
433
23
132
1.78
1.76
1.3
1.2
—
—
—
0
0
10
41
2.47
1.76
1.5
1.1
—
—
—
0
0
6
18
3.36
1.75
3.2
2.4
796.3
533.0
ml
—
6
11
9
36
2.53
1.74
1.1
1.1
—
—
—
0
0
8
30
2.69
1.73
4.1
3.0
—
—
—
0
0
13
61
2.16
1.73
1.6
1.5
—
—
—
0
0
5
13
3.87
1.72
1.0
1.9
—
—
—
0
0
40
269
1.53
1.69
16.2
14.6
1.4
1.2
inr
—
7
49
53
378
1.45
1.69
3.8
3.2
32.0
31.7
%
0.06
38
265
12
55
2.21
1.68
1.1
1.6
—
1.1
—
0
8
29
181
1.64
1.67
2.4
1.7
48.0
38.9
nmol/l
0.83
29
176
43
296
1.49
1.64
2.8
2.2
26.1
21.8
au/ml
—
5
23
5
14
3.59
1.62
1.0
1.9
—
—
—
0
0
28
175
1.63
1.61
2.1
1.7
—
—
—
0
0
7
26
2.71
1.58
1.6
1.1
—
—
—
0
0
6
20
3.02
1.58
1.5
1.5
—
—
—
0
0
12
57
2.13
1.56
1.2
1.1
—
—
—
0
0
10
44
2.30
1.54
1.1
1.5
—
—
—
0
0
33
218
1.55
1.53
1.2
1.4
—
—
—
0
0
5
15
3.35
1.52
1.0
2.1
—
—
—
0
0
12
58
2.09
1.50
1.2
1.8
0.0
0.0
g/l
0.00
12
58
10
45
2.25
1.47
1.1
1.5
—
—
—
0
0
10
45
2.25
1.47
1.1
1.5
—
—
—
0
0
10
45
2.25
1.47
1.1
1.5
—
—
—
0
0
10
45
2.25
1.47
1.1
1.5
—
—
—
0
0
10
45
2.25
1.47
1.1
1.5
—
—
—
0
0
6
22
2.75
1.44
1.0
2.4
—
—
—
0
0
115
951
1.27
1.42
4.7
3.1
1.0
1.0
kg/l
0.70
12
135
9
40
2.27
1.40
1.2
1.1
—
—
—
0
0
44
315
1.43
1.40
1.1
1.0
—
—
—
0
0
7
29
2.43
1.39
1.3
1.1
2.0
1.6
mmol/l
—
7
29
509
4976
1.71
1.37
28.7
14.5
137.3
137.6
g/l
0.16
503
4915
23
143
1.64
1.37
1.1
1.1
0.6
1.5
u/ml
0.98
14
53
9
42
2.16
1.34
1.1
1.0
—
—
—
0
0
82
656
1.30
1.32
1.3
1.2
1.3
8.8
u/ml
3.72
32
271
70
549
1.32
1.30
3.4
2.3
1.9
1.0
e6/l
0.97
48
298
40
287
1.43
1.28
10.6
9.0
0.5
0.9
mmol/l
0.43
35
220
66
519
1.31
1.21
3.4
2.5
3.5
3.7
e6/l
0.04
44
272
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
26
2.32
1.19
1.5
1.2
—
—
—
0
0
85
696
1.26
1.15
1.8
1.8
1.5
1.4
%
0.48
75
642
5
21
2.39
1.09
1.4
1.1
—
—
—
0
0
5
21
2.39
1.09
1.6
1.4
—
—
—
0
0
31
220
1.43
1.07
1.5
1.4
7.2
7.9
u/l
0.17
22
183
35
255
1.40
1.05
4.5
2.2
62.3
79.0
ml/min/173m2
1.33
21
101
10
53
1.90
1.02
1.2
1.8
0.0
0.0
g/l
—
10
53
10
53
1.90
1.02
2.9
3.7
10.9
4.8
u/ml
—
10
45
10
53
1.90
1.02
1.2
1.8
0.0
0.0
g/l
—
10
53
11
61
1.82
0.99
1.3
1.3
—
—
—
0
0
11
61
1.82
0.99
1.3
1.3
—
—
—
0
0
5
23
2.18
0.98
1.0
1.2
—
—
—
0
0
19
124
1.55
0.98
1.4
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.0
—
—
—
0
0
54
427
1.29
0.98
2.5
2.6
0.6
0.7
ug/l
0.61
25
234
71
582
1.25
0.97
3.6
3.6
23.1
21.5
%
0.14
25
227
13
77
1.71
0.96
1.2
1.7
—
—
—
0
0
48
375
1.31
0.95
1.2
1.3
108.3
157.5
iu/ml
0.41
15
150
399
3816
1.19
0.94
3.8
3.8
—
—
—
0
0
13
78
1.68
0.92
1.1
1.1
—
—
—
0
0
87
736
1.22
0.90
4.0
3.9
1.7
2.1
ug/l
0.31
81
666
20
287
0.68
0.88
2.0
1.7
—
—
—
0
0
8
44
1.83
0.86
4.4
2.1
—
—
—
0
0
12
72
1.68
0.86
1.6
1.6
—
—
—
0
0
6
31
1.95
0.84
2.7
1.6
—
—
—
0
0
37
287
1.31
0.79
10.9
8.9
5.1
5.1
kpa
0.05
37
270
37
287
1.31
0.79
10.8
8.9
12.0
13.6
kpa
1.67
37
271
11
66
1.68
0.79
1.3
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.5
—
—
—
0
0
18
123
1.48
0.78
1.4
1.2
—
—
—
0
0
22
158
1.41
0.75
6.3
9.7
24.5
24.3
mmol/l
0.08
22
145
38
299
1.29
0.74
1.1
1.4
348.0
262.2
miu/ml
0.52
15
153
9
55
1.65
0.74
1.2
1.1
—
—
—
0
0
37
291
1.29
0.73
1.5
1.5
376.8
300.0
mu/l
0.67
32
258
5
25
2.01
0.73
2.8
1.6
—
—
—
0
0
5
25
2.01
0.73
2.8
1.6
—
—
—
0
0
5
25
2.01
0.73
2.8
1.6
—
—
—
0
0
13
84
1.56
0.72
1.2
1.0
3.8
1.9
u/ml
—
8
42
5
26
1.93
0.71
1.4
1.1
72.2
70.1
u/l
—
5
16
14
93
1.52
0.70
1.4
1.1
—
—
—
0
0
11
70
1.58
0.65
1.2
1.8
11.5
10.1
g/l
0.38
11
65
42
342
1.25
0.65
1.6
1.4
—
—
—
0
0
10
63
1.60
0.62
1.2
1.7
37.1
39.6
g/l
—
10
56
45
538
0.82
0.59
1.5
1.5
—
—
—
0
0
24
309
0.77
0.59
1.5
1.6
—
—
—
0
0
148
1355
1.13
0.59
3.0
2.4
—
—
—
0
0
10
64
1.57
0.59
2.8
2.1
132.5
134.0
g/l
—
10
45
6
35
1.72
0.58
1.2
1.2
—
—
—
0
0
6
35
1.72
0.58
1.0
1.3
—
—
—
0
0
34
278
1.24
0.53
1.5
1.4
19.6
20.1
iu/l
0.03
26
229
6
40
1.51
0.51
1.5
1.3
—
—
—
0
0
29
234
1.25
0.50
1.4
1.7
5.7
3.3
mg/l
0.61
24
157
6
41
1.47
0.50
1.5
1.3
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
—
—
—
0
0
7
45
1.56
0.49
1.0
1.4
0.3
0.5
nmol/l
—
7
40
17
130
1.32
0.44
1.6
2.0
1.9
5.9
iu/l
—
6
46
5
31
1.62
0.43
1.2
1.5
—
0.1
u/ml
—
0
13
27
222
1.23
0.42
1.4
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
35.9
—
0
10
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
522.8
—
0
10
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
21
257
0.81
0.38
1.4
1.5
—
—
—
0
0
59
658
0.88
0.37
1.3
1.5
—
—
—
0
0
6
42
1.43
0.35
1.3
1.1
—
—
—
0
0
6
42
1.43
0.35
1.3
1.1
—
—
—
0
0
6
42
1.43
0.35
1.3
1.1
—
—
—
0
0
17
135
1.27
0.35
17.8
9.9
23.8
24.2
mmol/l
0.37
17
125
23
276
0.83
0.35
1.8
2.0
—
—
—
0
0
27
229
1.19
0.33
5.6
4.3
4.6
4.9
ug/l
0.08
21
177
8
66
1.22
0.27
1.1
1.5
—
12.1
—
0
8
12
149
0.80
0.26
1.5
1.6
—
—
—
0
0
9
76
1.19
0.24
1.0
2.3
—
—
—
0
0
6
82
0.73
0.24
1.7
1.7
12.5
13.0
%
—
6
82
15
124
1.22
0.24
1.5
1.9
—
—
—
0
0
131
1248
1.07
0.24
2.9
2.2
—
—
—
0
0
11
136
0.80
0.23
1.4
1.3
3.8
3.4
ug/l
0.10
11
128
11
88
1.26
0.22
3.3
3.7
25.7
22.4
mg/l
—
6
57
5
40
1.25
0.22
9.2
2.4
11.8
20.1
u/ml
—
5
40
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.16
0.21
15.0
20.8
1826.0
1492.2
nmol/l
—
5
43
77
816
0.93
0.19
2.5
2.0
—
—
—
0
0
6
51
1.18
0.19
1.5
1.1
—
—
—
0
0
6
51
1.18
0.19
1.5
1.1
—
—
—
0
0
6
53
1.13
0.18
3.2
2.2
—
—
—
0
0
19
167
1.14
0.17
1.9
1.5
—
—
—
0
0
385
3803
1.05
0.16
24.0
12.1
13.5
13.3
%
3.39
375
3734
35
374
0.93
0.12
1.1
1.5
—
—
—
0
0
22
201
1.10
0.11
1.4
2.4
18.8
46.2
u/ml
1.26
22
193
93
960
0.96
0.10
1.7
1.5
—
—
—
0
0
14
131
1.07
0.03
1.4
1.2
—
—
—
0
0
65
662
0.98
0.03
2.6
1.9
—
—
—
0
0
432
4307
1.02
0.03
18.6
10.3
39.8
40.9
%
1.82
349
3564
33
338
0.97
0.01
1.2
1.4
—
—
—
0
0
33
337
0.98
0.01
1.2
1.4
—
—
—
0
0
43
423
1.02
0.01
1.4
1.4
—
—
—
0
0
34
338
1.01
0.00
1.1
1.4
—
—
—
0
0
34
338
1.01
0.00
1.1
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
0.5
—
0
6
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.2
—
0
6
5
49
1.02
0.00
1.6
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_NAS | 1.745 [1.23, 2.48] | 0.002 |
| Birth year | 1.001 [0.99, 1.01] | 0.806 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1370 females with L12_ACNE_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_NAS | 2.269 [1.71, 3.0] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 1383 males with L12_ACNE_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.213% | 0.453% |
| 5 | 1.239% | 2.551% |
| 10 | 3.12% | 6.449% |
| 15 | 5.814% | 12.242% |
| 20 | 11.313% | 20.698% |
Relationships between endpoints
↥Index endpoint: L12_ACNE_NAS – Other and unspecified acne
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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