sebaceous gland disease: A skin disease that is located_in the sebaceous gland.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
563 |
4. Check minimum number of eventsNone |
563 |
5. Include endpointsNone |
563 |
6. Filter based on genotype QC (FinnGen only) |
541 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acne
based on the number of shared cases.
Similar with more cases:
- Acne
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4278 | 2091 | 2170 |
| Only index persons | 4081 | 2024 | 2057 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.08 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 23.04 | 26.01 | 20.09 |
| Only index persons | 22.92 | 25.91 | 19.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 541 | 329 | 212 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.10 |
| Median age at first event (years) | 27.45 | 28.61 | 25.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 563
- Matched controls
- 5630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.9
ICD-10 Finland
Acne, unspecified
294.5
307.7
308
23
L70.8
ICD-10 Finland
Other acne
721.9
243.2
223
5
L70.0
ICD-10 Finland
Acne vulgaris
23.3
216.1
173
105
D10BA01
ATC
isotretinoin; oral
13.5
204.1
254
324
J01AA04
ATC
lymecycline; systemic
7.0
109.3
233
516
J01AA07
ATC
tetracycline; systemic
6.5
101.1
231
542
L73.2
ICD-10 Finland
Hidradenitis suppurativa
41.7
75.4
46
12
D10AX03
ATC
azelaic acid; topical
5.3
59.7
145
344
G03HB01
ATC
cyproterone and estrogen; oral
4.3
43.5
139
403
L71.9
ICD-10 Finland
Rosacea, unspecified
14.6
40.3
37
27
L70
ICD-10 Finland
Acne
6.3
37.0
67
119
D06BX01
ATC
metronidazole; topical
4.6
35.4
93
230
E0001A1, ,
ATC
7.3
33.2
51
76
L70.1
ICD-10 Finland
Acne conglobata
342.1
32.2
32
*
70612
ICD-8 Finland
Diseases of sebaceous glands, Acne alia sive NUD
+∞
29.4
28
*
E0000UV, ,
ATC
2.6
26.6
300
1729
L72.1
ICD-10 Finland
Trichilemmal cyst
5.6
25.5
51
99
S96
ICPC
Acne
6.3
24.7
43
73
L04AX01
ATC
azathioprine; systemic
5.4
24.2
50
100
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.4
22.8
60
147
TQW80
NOMESCO Finland
Local dermatologic skincare
7.8
22.7
32
43
L73.8
ICD-10 Finland
Other specified follicular disorders
28.7
22.5
30
11
XQ848
NOMESCO Finland
Dermatological photography
7.7
21.0
30
41
L04AA06
ATC
mycophenolic acid; systemic
9.0
20.8
26
30
L71.8
ICD-10 Finland
Other rosacea
24.5
20.1
28
12
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
19.9
147
678
J01FF01
ATC
clindamycin; systemic
2.4
18.7
163
808
L71
ICD-10 Finland
Rosacea
7.4
18.4
27
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
18.3
214
1203
D10AF01
ATC
clindamycin; topical
4.1
17.9
52
137
E000001, ,
ATC
2.4
17.2
158
798
H02AB06
ATC
prednisolone; systemic
2.1
16.8
254
1569
UJF32
NOMESCO Finland
Coloscopy
2.5
16.1
120
550
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
5.1
14.9
32
66
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
14.6
131
651
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
4.3
14.2
38
94
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
13.0
37
96
L04AD01
ATC
ciclosporin; systemic
6.4
12.5
21
34
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
12.3
80
341
SPAT1301
SPAT
No procedures
2.0
12.2
183
1099
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.4
12.1
22
20
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.6
12.1
24
26
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.4
12.0
94
438
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
12.1
11.9
21
18
S10
ICPC
Boil/carbuncle
3.3
11.7
46
149
L30.3
ICD-10 Finland
Infective dermatitis
4.5
11.4
28
65
D07AC01
ATC
betamethasone; topical
1.9
11.3
189
1174
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.7
11.2
21
38
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
20.5
11.2
16
8
D07AD01
ATC
clobetasol; topical
2.4
11.1
84
385
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
10.8
244
1662
C03DA01
ATC
spironolactone; oral
3.1
10.7
46
157
Z94.0
ICD-10 Finland
Kidney transplant status
12.4
10.4
18
15
N02AX02
ATC
tramadol; systemic, rectal
1.9
10.4
193
1234
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
10.2
220
1470
TK800
NOMESCO Finland
Hemodialysis
8.7
10.1
21
25
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.6
10.0
33
95
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.9
118
648
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.1
9.7
111
599
H02AB04
ATC
methylprednisolone; systemic
2.4
9.7
71
320
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
15.4
9.6
15
10
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
9.4
9
*
V03AE01
ATC
polystyrene sulfonate; oral
22.1
9.4
13
6
J01AA02
ATC
doxycycline; systemic
1.8
9.4
359
2808
L71.0
ICD-10 Finland
Perioral dermatitis
4.8
9.4
21
45
SPAT1153
SPAT
Removal of sutures
1.9
9.4
135
791
A02BC02
ATC
pantoprazole; systemic
1.7
9.3
311
2337
A12AA04
ATC
calcium carbonate; oral
10.9
9.3
17
16
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
9.3
133
776
N18.8
ICD-10 Finland
Other chronic renal failure
9.7
9.3
18
19
127
Kela drug reimbursment
Transplant complication
7.5
9.3
21
29
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
9.3
54
218
J01DB01
ATC
cefalexin; oral
2.1
9.2
472
4027
N03AX16
ATC
[U] pregabalin
2.1
9.1
103
553
Z49.1
ICD-10 Finland
Extracorporeal dialysis
15.9
9.1
14
9
R42
ICD-10 Finland
Dizziness and giddiness
2.1
9.0
96
504
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
9.0
105
571
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.3
8.9
33
103
ZYC01
NOMESCO Finland
Remote contact by phone
2.8
8.9
46
175
SPAT1310
SPAT
Counselling related to known health issue
1.8
8.8
200
1344
N06AB03
ATC
fluoxetine; oral
2.3
8.8
73
347
A11CC03
ATC
alfacalcidol; systemic
7.1
8.6
20
29
J04BA02
ATC
dapsone; oral
16.6
8.6
13
8
A02BC01
ATC
omeprazole; systemic
1.9
8.5
127
751
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.9
8.4
40
145
L04AD02
ATC
tacrolimus; systemic
8.7
8.4
17
20
7061X
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE ALIA DEFINITA]
+∞
8.4
8
*
L04AA01
ATC
[U] ciclosporin
11.0
8.3
15
14
137
Kela drug reimbursment
Uraemia requiring dialysis
11.0
8.3
15
14
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.9
8.3
24
63
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
8.3
170
1106
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.2
8.2
32
103
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
8.2
48
194
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.4
8.2
30
93
N02BE01
ATC
paracetamol; systemic, rectal
2.0
8.2
473
4089
J01CF05
ATC
flucloxacillin; systemic
2.7
8.1
44
171
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.4
8.0
20
47
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.9
8.0
38
138
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
7.9
7.9
17
22
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.5
7.9
27
80
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.3
7.8
20
48
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
7.8
193
1321
K51.5
ICD-10 Finland
Left sided colitis
3.5
7.8
27
81
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.5
7.8
27
81
L68.0
ICD-10 Finland
Hirsutism
45.6
7.7
9
*
B03XA01
ATC
erythropoietin; parenteral
45.6
7.7
9
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.2
7.7
64
304
SPAT1255
SPAT
Intravenous administration of medicine
3.0
7.7
33
113
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.1
7.6
32
108
B03XA02
ATC
darbepoetin alfa; parenteral
10.2
7.6
14
14
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
7.5
44
178
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
7.3
7.5
17
24
S29
ICPC
Skin symptom/complaint other
1.9
7.4
106
616
D05BB02
ATC
acitretin; oral
7.0
7.3
17
25
D07AC13
ATC
mometasone; topical
1.8
7.3
143
913
B05DA
ATC
Isotonic solutions
11.1
7.3
13
12
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
7.3
227
1641
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
7.3
7
*
A07EC02
ATC
mesalazine; oral, rectal
2.7
7.3
38
145
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.8
7.3
35
128
A02BC05
ATC
esomeprazole; systemic
1.7
7.3
177
1202
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
16.0
7.3
11
7
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.9
7.2
33
117
L01BA01
ATC
methotrexate; systemic
4.0
7.2
20
51
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
7.2
109
645
N06AX11
ATC
mirtazapine; oral
1.7
7.2
173
1171
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
7.1
50
221
Z49.2
ICD-10 Finland
Other dialysis
12.2
7.1
12
10
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
7.1
63
308
L72.0
ICD-10 Finland
Epidermal cyst
10.2
7.1
13
13
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
7.1
26
81
J01FA01
ATC
erythromycin; systemic
1.9
7.1
99
571
J01MA12
ATC
levofloxacin; systemic
2.0
7.0
75
393
L84
ICD-10 Finland
Corns and callosities
4.0
7.0
20
52
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
7.0
95
543
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.1
6.9
19
48
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3.3
6.9
26
82
AA1AD
NOMESCO Finland
CT of head and brain
1.9
6.9
95
544
KBV00
NOMESCO Finland
Insertion of stent into ureter
14.0
6.9
11
8
H02AB09
ATC
hydrocortisone; systemic
3.9
6.9
20
53
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.3
6.8
52
238
B05DB
ATC
Hypertonic solutions
11.1
6.8
12
11
P01AB01
ATC
metronidazole; oral, rectal
1.6
6.8
197
1395
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
6.8
48
213
L73.9
ICD-10 Finland
Follicular disorder, unspecified
16.9
6.8
10
6
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
3.4
6.8
24
73
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
6.6
87
490
R06AE07
ATC
cetirizine; oral
1.6
6.6
258
1959
SXC05
NOMESCO Finland
Other oral or dental procedure
2.2
6.6
55
262
A04AA01
ATC
ondansetron; systemic, rectal
2.7
6.6
36
141
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.0
6.5
77
418
WW200
NOMESCO Finland
Immunization
3.7
6.5
20
55
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.1
6.5
59
291
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.7
6.4
33
125
ZX120
NOMESCO Finland
Intravenous
2.4
6.4
42
180
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
6.4
25
81
N03AX12
ATC
[U] gabapentin; oral
2.0
6.4
71
378
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.3
79
438
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
6.3
192
1371
N05CF01
ATC
zopiclone; oral
1.7
6.3
126
807
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
18.3
6.3
9
5
V03AE02
ATC
sevelamer; oral
18.3
6.3
9
5
C03CA01
ATC
furosemide; systemic
2.1
6.3
65
337
SPAT1262
SPAT
Handing over of treatment supplies
2.0
6.3
70
373
70610
ICD-8 Finland
Diseases of sebaceous glands, Acne vulgaris
+∞
6.3
6
*
70600
ICD-8 Finland
Diseases of sebaceous glands, Acne necrotica
+∞
6.3
6
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.3
209
1525
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.2
159
1087
TQW99
NOMESCO Finland
Other minor procedure on skin
3.4
6.2
22
67
SPAT1240
SPAT
Therapeutic discussion
1.9
6.2
88
509
Z01.2
ICD-10 Finland
Dental examination
1.6
6.1
281
2200
N06AX16
ATC
venlafaxine; oral
1.9
6.1
87
503
S18
ICPC
Laceration/cut
1.6
6.1
203
1478
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
8.7
6.1
12
14
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
10.2
6.1
11
11
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
6.0
92
544
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
224
1355
2.08
15.29
11.3
7.9
1.14
1.11
inr
0.28
77
464
110
501
2.49
14.90
4.9
2.2
13.07
14.84
umol/l
1.88
105
467
398
2986
2.14
14.83
11.8
6.3
74.81
74.13
u/l
0.13
367
2809
195
1144
2.08
14.26
3.9
2.4
56.11
61.77
u/l
0.60
180
1061
278
1864
1.97
13.84
7.8
5.7
9.38
10.61
umol/l
1.73
258
1761
297
2060
1.93
13.15
10.3
5.8
2.69
2.77
%
0.29
284
1942
312
2217
1.91
12.66
7.1
4.5
6.44
6.39
mmol/l
0.16
292
1980
221
1403
1.95
12.61
10.5
4.6
36.76
37.31
g/l
0.83
212
1333
341
2501
1.92
12.50
14.1
8.1
4.24
3.94
e9/l
1.65
315
2186
166
961
2.03
12.29
2.8
1.9
2.69
2.78
mg/l
0.25
146
821
304
2156
1.89
12.27
9.5
5.6
57.12
55.97
%
1.09
293
2043
307
2185
1.89
12.24
10.2
5.7
28.23
29.88
%
2.24
295
2073
102
492
2.31
12.00
2.0
1.8
—
—
—
0
0
100
487
2.28
11.47
1.8
1.6
1312.05
1188.50
nmol/l
0.68
73
373
32
84
3.98
11.08
5.1
3.8
55.81
56.12
%
0.04
32
84
221
1455
1.85
10.92
11.8
5.5
1.22
1.21
mmol/l
0.12
201
1332
89
421
2.32
10.91
5.7
2.2
23.23
25.09
%
0.58
81
371
391
3088
1.87
10.42
5.6
3.5
10.08
8.57
mm/h
1.34
367
2865
236
1622
1.78
9.87
12.8
5.9
1.21
1.21
mmol/l
0.20
200
1378
41
146
2.95
8.89
3.6
4.0
3.31
3.46
g/l
0.33
41
141
532
4796
2.98
8.73
15.0
7.9
26.65
27.13
u/l
0.22
519
4639
234
1647
1.72
8.72
3.3
2.3
73.90
71.42
nmol/l
0.57
223
1522
194
1297
1.76
8.68
1.9
1.6
94.92
97.60
pmol/l
0.34
106
680
70
332
2.27
8.47
1.7
1.7
—
—
—
0
0
98
535
2.01
8.26
8.5
4.1
0.80
0.83
mmol/l
1.45
93
506
62
284
2.33
8.13
9.3
4.5
1.25
1.81
mmol/l
0.89
56
229
40
149
2.81
8.01
2.0
1.6
0.00
0.04
iu/ml
—
7
27
109
626
1.92
7.91
3.8
3.1
1455.89
648.07
ng/l
1.51
85
484
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
75
3.59
7.91
6.2
4.8
0.28
0.30
u/ml
0.09
13
42
69
337
2.19
7.77
2.0
1.7
—
—
—
0
0
208
1453
1.68
7.76
4.2
3.2
31.84
30.12
u/l
0.28
197
1376
17
23
7.59
7.72
1.0
1.0
1404.12
1700.87
miu/ml
0.52
17
23
20
49
4.20
7.59
1.3
1.2
—
—
—
0
0
121
728
1.84
7.59
3.6
2.5
175.32
110.46
ug/g
0.86
95
577
167
1107
1.72
7.52
5.1
2.8
2.33
2.35
mmol/l
1.21
155
1003
418
3515
1.73
7.43
4.6
3.7
14.72
14.46
pmol/l
1.38
379
3226
176
1199
1.68
7.11
3.8
2.8
39.00
40.91
ng/l
0.03
94
580
110
658
1.83
6.99
1.6
1.5
120213171.79
23570620.85
pmol/l
0.54
94
577
389
3234
1.66
6.95
3.4
2.9
41.65
35.99
u/l
0.77
369
3088
342
2757
1.61
6.90
5.4
3.6
437.80
172.45
e6/l
—
5
29
30
105
2.96
6.73
2.1
1.5
113.56
111.44
u/ml
—
9
16
20
54
3.80
6.69
1.3
1.2
—
—
—
0
0
83
460
1.94
6.65
3.3
2.3
6707.56
4390.74
u/l
0.28
30
199
11
9
12.43
6.60
6.5
5.3
—
—
—
0
0
458
4017
1.75
6.25
4.5
3.1
1.34
1.24
mmol/l
1.99
434
3788
35
141
2.58
6.07
1.7
1.2
—
—
—
0
0
292
2313
1.55
6.01
4.5
2.8
100.58
77.83
ug/l
1.77
274
2158
34
136
2.60
5.98
1.7
1.3
210.02
222.81
u/ml
0.13
28
86
141
948
1.65
5.84
2.3
2.1
132.74
262.92
u/l
1.15
131
900
45
208
2.26
5.80
2.2
1.6
—
—
—
0
0
473
4214
1.77
5.76
4.9
3.4
4.62
4.68
mmol/l
0.72
449
4003
483
4340
1.79
5.56
20.8
9.9
3.95
3.92
mmol/l
1.57
465
4186
17
47
3.70
5.52
1.8
1.8
—
—
—
0
0
481
4323
1.77
5.46
20.2
9.9
139.33
139.59
mmol/l
1.91
468
4182
24
84
2.94
5.42
1.6
1.7
—
—
—
0
0
19
58
3.36
5.35
1.5
1.8
—
—
—
0
0
503
4590
1.90
5.31
20.7
9.8
18.87
20.09
mg/l
0.41
424
3461
17
49
3.55
5.21
1.5
1.6
—
—
—
0
0
158
1121
1.57
5.17
1.5
1.4
2.43
2.10
g/l
1.26
106
699
64
355
1.91
5.11
9.8
6.6
104.19
104.54
mmol/l
0.27
64
355
24
87
2.84
5.10
2.6
1.6
—
—
—
0
0
107
694
1.67
5.04
1.6
1.3
19.21
20.13
nmol/l
0.25
95
602
114
754
1.64
4.97
5.3
2.3
4.34
8.51
e6/l
2.68
105
661
137
949
1.59
4.95
2.6
2.0
0.95
0.93
mg/l
0.04
103
680
253
1999
1.48
4.94
3.2
2.5
—
—
—
0
0
462
4138
1.65
4.93
5.3
4.3
1.73
2.35
mu/l
0.92
431
3881
26
101
2.65
4.87
1.1
1.1
—
—
—
0
0
16
38
4.30
4.85
1.6
2.0
—
—
—
0
0
121
817
1.61
4.85
6.4
4.1
27.77
12.09
mg/mmol
0.77
86
537
271
2178
1.47
4.82
4.7
3.0
0.00
0.00
estimate
-0.00
66
473
42
206
2.12
4.72
8.1
3.2
0.37
1.43
mmol/l
0.79
34
143
23
86
2.75
4.64
1.7
1.7
—
—
—
0
0
16
48
3.40
4.63
1.3
1.6
—
—
—
0
0
143
1015
1.55
4.61
5.4
2.6
0.27
0.34
e6/l
0.28
116
738
15
36
4.25
4.54
1.3
1.5
—
—
—
0
0
15
44
3.48
4.49
1.9
1.7
—
—
—
0
0
15
44
3.48
4.49
1.9
1.7
—
—
—
0
0
269
2180
1.45
4.47
5.9
4.1
0.00
0.00
estimate
0.50
68
468
152
1101
1.52
4.45
4.7
3.3
8.25
8.86
mmol/l
0.59
129
970
449
4025
1.57
4.43
4.0
3.3
5.79
5.66
mmol/l
0.99
409
3729
18
61
3.02
4.32
1.2
1.9
—
—
—
0
0
35
166
2.18
4.29
3.4
2.7
142.07
92.59
ng/l
0.45
28
145
17
56
3.10
4.27
1.1
1.5
—
—
—
0
0
17
56
3.10
4.27
1.9
1.9
—
—
—
0
0
91
590
1.65
4.27
4.1
3.0
514.20
677.10
ng/l
0.17
50
344
172
1288
1.48
4.27
6.1
2.8
—
—
—
0
0
134
954
1.53
4.23
3.2
2.0
—
—
—
0
0
64
378
1.78
4.20
2.8
2.1
10.81
13.35
nmol/l
1.48
57
354
270
2208
1.43
4.18
4.7
3.0
0.00
0.00
estimate
-0.00
64
445
58
333
1.83
4.18
3.2
2.8
—
—
—
0
0
32
149
2.22
4.10
1.6
1.4
—
—
—
0
0
28
124
2.32
4.03
1.9
1.9
—
—
—
0
0
40
205
2.02
4.03
1.8
1.4
—
—
—
0
0
29
131
2.28
4.00
1.9
2.0
—
—
—
0
0
49
272
1.88
3.93
9.9
7.0
1.21
1.29
mmol/l
0.29
49
265
219
1739
1.42
3.93
4.8
2.9
—
—
—
0
0
14
37
3.85
3.92
1.6
1.7
—
—
—
0
0
122
867
1.52
3.86
3.6
2.5
2826.50
3321.60
umol/l
0.07
105
794
461
4196
1.54
3.84
4.5
3.3
1.43
1.44
mmol/l
0.25
436
3970
405
3596
1.45
3.79
6.0
4.2
38.57
37.92
mmol/mol
0.56
377
3403
18
67
2.74
3.69
2.6
2.1
—
—
—
0
0
155
1167
1.45
3.67
5.7
3.1
0.00
0.01
estimate
1.08
66
456
70
445
1.65
3.55
3.0
3.5
5.95
6.83
umol/l
0.30
61
374
18
69
2.66
3.50
1.4
1.2
—
—
—
0
0
27
126
2.20
3.47
6.2
3.6
0.80
0.66
%
1.00
27
126
463
4245
1.51
3.45
4.7
3.6
2.75
2.84
mmol/l
1.34
434
4003
13
42
3.14
3.39
1.3
1.9
—
—
—
0
0
9
19
4.80
3.25
5.2
2.1
—
—
—
0
0
18
72
2.55
3.24
12.8
2.5
5.19
4.91
kpa
1.03
18
72
28
137
2.10
3.22
3.5
2.1
—
—
—
0
0
132
987
1.44
3.20
2.3
1.6
1.46
1.40
mmol/l
0.24
115
859
161
1259
1.39
3.02
1.4
1.3
0.76
1.66
u/ml
1.60
49
334
19
81
2.39
3.01
3.5
3.4
—
—
—
0
0
16
63
2.58
2.98
1.8
1.7
—
—
—
0
0
16
63
2.58
2.98
1.8
1.7
—
—
—
0
0
25
121
2.12
2.97
6.8
2.9
24.78
25.00
mmol/l
0.16
25
115
9
22
4.14
2.89
1.0
1.2
—
—
—
0
0
10
28
3.62
2.79
1.0
1.2
—
—
—
0
0
445
4099
1.41
2.77
16.4
8.3
93.92
95.77
ml/min/173m2
0.79
367
3206
43
258
1.72
2.73
10.1
9.1
118.53
124.40
g/l
0.88
43
249
14
54
2.63
2.72
3.6
2.4
16.68
17.04
%
—
8
22
52
330
1.63
2.69
2.4
1.8
—
—
—
0
0
42
252
1.72
2.67
11.1
2.9
1.22
1.22
mmol/l
0.22
36
217
48
299
1.66
2.66
2.8
3.5
4.62
4.68
pmol/l
0.14
43
270
17
74
2.34
2.60
1.3
1.1
—
—
—
0
0
14
57
2.49
2.46
7.9
2.8
1.32
1.06
%
0.18
14
52
20
97
2.10
2.40
1.8
1.6
3.83
3.63
mmol/l
0.31
20
92
17
77
2.25
2.39
1.2
1.4
—
—
—
0
0
12
46
2.64
2.37
1.7
1.1
166.88
224.77
mg/l
1.90
12
39
11
39
2.86
2.35
1.5
1.4
—
—
—
0
0
547
5304
2.10
2.32
28.9
14.3
263.67
256.79
e9/l
1.62
537
5181
178
1465
1.31
2.31
1.9
1.7
—
—
—
0
0
12
47
2.59
2.28
1.8
1.1
32.95
34.96
mg/l
0.07
12
34
31
179
1.77
2.27
2.0
1.7
—
—
—
0
0
17
79
2.19
2.27
1.4
1.2
—
—
—
0
0
58
396
1.52
2.23
3.6
3.2
32.14
31.54
%
0.16
43
283
73
523
1.45
2.22
5.1
2.4
2.42
2.42
mmol/l
0.04
65
456
8
24
3.37
2.18
1.1
1.7
—
—
—
0
0
80
586
1.43
2.16
3.4
2.3
1.68
0.97
e6/l
0.85
54
314
10
36
2.81
2.14
1.1
1.1
—
—
—
0
0
21
109
1.96
2.13
1.8
1.7
364.48
394.10
mg/l
0.28
21
104
547
5315
2.03
2.12
28.9
14.2
4.58
4.61
e12/l
0.52
534
5182
8
25
3.23
2.10
1.8
3.5
1634.00
600.08
u/ml
—
8
25
11
43
2.59
2.09
1.5
1.1
—
—
—
0
0
547
5321
1.99
2.01
29.1
14.4
137.06
137.65
g/l
0.43
540
5260
13
57
2.31
1.99
1.2
1.8
—
1.15
—
0
8
75
552
1.41
1.99
3.4
2.5
3.27
3.69
e6/l
0.11
48
285
546
5310
1.94
1.98
29.2
14.3
40.51
41.77
%
0.76
525
5054
7
21
3.36
1.97
2.7
2.6
30.14
26.10
umol/l
—
7
21
97
747
1.36
1.96
1.8
1.8
1.43
1.40
%
0.19
86
691
54
374
1.49
1.96
5.2
5.0
—
—
—
0
0
45
300
1.54
1.94
10.0
9.2
0.41
0.94
mmol/l
0.48
39
237
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
27
2.99
1.94
1.4
1.1
—
—
—
0
0
20
107
1.90
1.88
2.2
2.4
9.11
11.11
mg/l
0.66
20
101
16
79
2.06
1.87
1.3
1.4
—
1.44
—
0
8
6
17
3.56
1.84
1.3
1.1
75.33
96.65
%
—
6
17
9
35
2.60
1.80
1.1
1.1
—
—
—
0
0
13
60
2.19
1.79
1.3
1.8
0.00
0.00
g/l
-0.00
13
60
14
67
2.12
1.77
1.3
1.1
—
—
—
0
0
18
95
1.92
1.77
1.6
1.3
4.00
3.97
u/ml
—
8
39
31
194
1.63
1.75
2.3
1.6
46.71
38.13
nmol/l
0.82
31
189
48
333
1.48
1.75
1.1
1.0
—
—
—
0
0
40
267
1.54
1.74
4.2
2.2
63.23
80.08
ml/min/173m2
1.38
23
105
5
13
3.87
1.72
1.0
3.2
—
—
—
0
0
5
13
3.87
1.72
1.0
1.9
—
—
—
0
0
5
13
3.87
1.72
1.0
3.2
—
—
—
0
0
14
68
2.09
1.71
1.6
1.5
—
—
—
0
0
45
310
1.49
1.70
2.7
2.2
26.06
23.11
au/ml
—
5
29
6
19
3.18
1.66
2.5
2.4
754.67
514.42
ml
—
6
12
26
158
1.68
1.65
1.5
1.4
—
—
—
0
0
5
14
3.59
1.62
1.0
1.9
—
—
—
0
0
8
32
2.52
1.60
4.1
3.8
—
—
—
0
0
123
1010
1.28
1.59
4.7
3.0
1.02
1.02
kg/l
0.69
12
147
18
99
1.85
1.59
1.7
1.2
2.00
5.18
u/ml
—
10
33
91
718
1.32
1.58
1.3
1.2
14.04
25.34
iu/ml
1.67
22
222
18
100
1.83
1.54
5.2
9.5
1.67
1.46
%
0.87
18
88
5
15
3.35
1.52
1.0
2.1
—
—
—
0
0
7
27
2.61
1.52
1.6
1.1
—
—
—
0
0
6
21
2.88
1.51
1.5
1.6
—
—
—
0
0
10
45
2.24
1.47
2.0
1.5
—
—
—
0
0
87
690
1.31
1.47
1.3
1.2
1.29
8.67
u/ml
3.79
34
280
433
4091
1.25
1.46
3.8
3.8
—
—
—
0
0
78
610
1.32
1.45
3.7
3.6
22.08
21.69
%
0.03
27
235
5
16
3.14
1.44
1.6
1.4
—
—
—
0
0
6
22
2.75
1.44
1.3
1.1
—
—
—
0
0
10
46
2.20
1.40
1.1
1.5
—
—
—
0
0
42
300
1.43
1.36
10.1
9.1
12.10
13.66
kpa
1.75
42
284
42
300
1.43
1.36
10.2
9.2
5.08
5.11
kpa
0.09
42
283
10
47
2.15
1.34
1.1
1.4
—
—
—
0
0
10
47
2.15
1.34
1.1
1.4
—
—
—
0
0
10
47
2.15
1.34
1.1
1.4
—
—
—
0
0
10
47
2.15
1.34
1.1
1.4
—
—
—
0
0
10
47
2.15
1.34
1.1
1.4
—
—
—
0
0
9
42
2.16
1.34
1.2
1.2
—
—
—
0
0
24
152
1.60
1.34
1.3
1.2
—
—
—
0
0
6
24
2.52
1.30
1.0
2.3
—
—
—
0
0
33
227
1.48
1.29
1.2
1.4
—
—
—
0
0
11
55
2.02
1.28
1.4
1.7
0.00
0.00
g/l
-0.00
11
55
11
55
2.02
1.28
1.4
1.7
0.00
0.00
g/l
-0.00
11
55
94
768
1.27
1.27
4.1
3.9
1.70
2.05
ug/l
0.32
88
698
9
44
2.06
1.27
1.1
1.0
—
—
—
0
0
21
131
1.63
1.25
1.3
1.2
—
—
—
0
0
17
100
1.72
1.24
1.3
1.4
201.02
317.70
ug/g
—
8
57
25
164
1.55
1.22
7.1
10.1
24.37
24.34
mmol/l
0.01
25
153
58
449
1.33
1.18
2.7
2.5
0.56
0.70
ug/l
0.83
27
245
13
72
1.82
1.16
1.2
1.3
—
—
—
0
0
12
65
1.86
1.14
1.3
1.2
—
—
—
0
0
12
65
1.86
1.14
1.3
1.2
—
—
—
0
0
14
80
1.77
1.14
1.3
1.7
—
—
—
0
0
5
21
2.39
1.09
1.6
1.4
—
—
—
0
0
20
129
1.57
1.07
1.4
1.1
—
—
—
0
0
13
75
1.75
1.03
1.6
1.6
—
—
—
0
0
5
23
2.18
0.98
1.4
1.0
—
—
—
0
0
51
400
1.30
0.97
1.2
1.3
108.27
170.58
iu/ml
0.55
15
159
47
365
1.31
0.96
1.5
1.4
—
—
—
0
0
7
37
1.90
0.94
1.0
1.2
—
—
—
0
0
23
159
1.47
0.92
1.1
1.1
1.81
3.64
u/ml
0.70
17
80
32
237
1.37
0.90
1.5
1.5
7.23
7.52
u/l
0.07
22
197
8
47
1.71
0.81
4.4
2.1
—
—
—
0
0
10
58
1.74
0.80
1.2
1.1
—
—
—
0
0
0
26
0.00
0.78
0.0
1.5
—
—
—
0
0
40
315
1.29
0.77
1.5
1.5
361.69
300.71
mu/l
0.54
35
280
40
315
1.29
0.77
1.1
1.4
348.02
256.89
miu/ml
0.57
15
162
19
135
1.42
0.70
1.5
1.9
—
—
—
0
0
13
85
1.54
0.69
1.1
1.1
—
—
—
0
0
48
579
0.81
0.67
1.5
1.5
—
—
—
0
0
159
1449
1.14
0.67
2.9
2.4
—
—
—
0
0
37
295
1.27
0.67
1.5
1.4
19.06
19.48
iu/l
0.02
27
243
5
28
1.79
0.66
2.8
1.6
—
—
—
0
0
5
28
1.79
0.66
2.8
1.6
—
—
—
0
0
5
28
1.79
0.66
2.8
1.6
—
—
—
0
0
428
4144
1.14
0.63
23.9
12.0
14.66
13.98
%
1.71
420
4076
30
235
1.29
0.62
7.9
4.2
4.42
4.93
ug/l
0.15
24
182
8
50
1.61
0.61
1.6
1.3
130.47
193.22
pmol/l
—
8
50
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
24
308
0.77
0.58
2.1
1.7
—
—
—
0
0
6
36
1.67
0.57
1.2
1.2
—
—
—
0
0
13
90
1.45
0.56
1.2
1.0
3.84
1.79
u/ml
—
8
45
6
37
1.63
0.55
2.7
1.6
—
—
—
0
0
18
133
1.37
0.55
1.1
1.1
2.22
2.31
u/ml
0.02
13
66
14
100
1.41
0.52
1.4
1.1
—
—
—
0
0
6
40
1.51
0.51
1.5
1.3
—
—
—
0
0
6
41
1.47
0.50
1.5
1.3
—
—
—
0
0
10
68
1.48
0.47
2.9
2.1
130.10
134.00
g/l
—
10
47
7
50
1.40
0.45
1.0
1.5
0.26
0.46
nmol/l
—
7
45
29
240
1.22
0.42
1.4
1.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.5
—
0.40
u/ml
—
0
19
0
17
0.00
0.40
0.0
1.0
—
522.80
—
0
10
0
17
0.00
0.40
0.0
1.0
—
35.90
—
0
10
17
132
1.30
0.40
1.6
1.9
1.85
5.89
iu/l
—
6
46
8
60
1.34
0.40
2.6
2.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
12
89
1.36
0.38
3.2
3.7
27.04
22.54
mg/l
—
7
58
142
1333
1.09
0.35
2.8
2.2
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
6
45
1.34
0.34
1.3
1.1
—
—
—
0
0
6
45
1.34
0.34
1.3
1.1
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
6
46
1.31
0.33
1.3
1.2
—
—
—
0
0
7
55
1.28
0.30
1.4
1.1
—
—
—
0
0
7
55
1.28
0.30
1.4
1.1
—
—
—
0
0
64
698
0.91
0.28
1.4
1.5
—
—
—
0
0
21
178
1.19
0.26
1.8
1.5
—
—
—
0
0
13
158
0.82
0.24
1.5
1.6
—
—
—
0
0
29
325
0.89
0.21
1.6
1.6
—
—
—
0
0
5
42
1.19
0.21
1.2
1.9
—
—
—
0
0
24
272
0.88
0.21
1.5
1.5
—
—
—
0
0
5
43
1.16
0.21
9.2
2.5
11.80
19.57
u/ml
—
5
43
36
396
0.90
0.20
1.1
1.5
—
—
—
0
0
12
99
1.22
0.19
1.0
1.0
0.19
0.53
u/ml
—
6
28
6
53
1.13
0.18
1.5
1.1
—
—
—
0
0
27
297
0.90
0.16
1.7
2.0
—
—
—
0
0
84
875
0.95
0.13
2.4
2.0
—
—
—
0
0
10
85
1.18
0.12
1.0
2.3
—
—
—
0
0
23
210
1.10
0.12
1.4
2.4
19.34
45.35
u/ml
1.24
23
202
5
44
1.14
0.10
15.0
20.8
1802.40
1535.75
nmol/l
—
5
44
13
145
0.89
0.09
1.3
1.3
3.95
3.32
ug/l
0.21
13
137
34
359
0.94
0.08
1.1
1.5
—
—
—
0
0
34
358
0.95
0.08
1.1
1.5
—
—
—
0
0
100
1017
0.98
0.04
1.7
1.5
—
—
—
0
0
35
359
0.97
0.02
1.1
1.5
—
—
—
0
0
35
359
0.97
0.02
1.1
1.5
—
—
—
0
0
70
710
0.98
0.02
2.4
1.9
—
—
—
0
0
46
452
1.02
0.01
1.4
1.4
—
—
—
0
0
14
146
0.96
0.00
1.4
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.16
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
0.50
—
0
6
5
55
0.91
-0.00
1.2
1.1
1.57
1.39
g/l
—
5
47
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_NAS | 1.745 [1.23, 2.48] | 0.002 |
| Birth year | 1.001 [0.99, 1.01] | 0.806 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1370 females with L12_ACNE_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_NAS | 2.269 [1.71, 3.0] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 1383 males with L12_ACNE_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.213% | 0.453% |
| 5 | 1.239% | 2.551% |
| 10 | 3.12% | 6.449% |
| 15 | 5.814% | 12.242% |
| 20 | 11.313% | 20.698% |
Relationships between endpoints
↥Index endpoint: L12_ACNE_NAS – Other and unspecified acne
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data