No definition available.
Other specified/unspecified deforming dorsopathies
EFO MESH Endpoint Browser PheWeb
M13_DEFORMDORSONAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
728 |
4. Check minimum number of eventsNone |
728 |
5. Include endpointsNone |
728 |
6. Filter based on genotype QC (FinnGen only) |
728 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified deforming dorsopathies
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6805 | 4430 | 2315 |
| Only index persons | 5608 | 3751 | 1857 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.06 |
| Only index persons | 0.12 | 0.14 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 27.44 | 27.05 | 27.44 |
| Only index persons | 20.06 | 19.14 | 21.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 728 | 526 | 202 |
| Unadjusted period prevalence (%) | 0.15 | 0.18 | 0.09 |
| Median age at first event (years) | 21.31 | 17.19 | 32.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 658
- Matched controls
- 6580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
73599
ICD-8 Finland
Other and unspecified curvature of spine
+∞
323.0
303
*
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
90.8
85
*
7328A
ICD-9 Finland
Osteochondropathies, Other specified forms of osteochondropathy[JALKATERÄN YLIMÄÄRÄISTEN LUIDEN AIHEUTTAMAT OIREET]
+∞
77.7
73
*
7328B
ICD-9 Finland
Osteochondropathies, Other specified forms of osteochondropathy[MUIDEN YLIMÄÄRÄISTEN LUIDEN AIHEUTTAMAT OIREET]
+∞
76.6
72
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
28.4
66.4
91
37
9102
FHL
Trepanation or removal of the local bone process
61.2
65.5
76
14
M48.0
ICD-10 Finland
Spinal stenosis
35.4
54.2
70
22
M41.9
ICD-10 Finland
Scoliosis, unspecified
191.8
51.7
53
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
21.7
48.7
72
37
M43.1
ICD-10 Finland
Spondylolisthesis
57.5
45.3
53
10
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
52.8
41.3
49
10
9103
FHL
Partial or complete bone removal
422.2
40.6
40
*
N03AX12
ATC
gabapentin; oral
6.0
40.4
120
235
7373A
ICD-9 Finland
Curvature of spine, Kyphoscoliosis and scoliosis
+∞
40.0
38
*
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
+∞
37.9
36
*
M41.2
ICD-10 Finland
Other idiopathic scoliosis
+∞
34.7
33
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
19.4
34.2
52
29
M43.0
ICD-10 Finland
Spondylolysis
+∞
32.6
31
*
N02AX02
ATC
tramadol; systemic, rectal
2.9
32.5
274
1308
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
+∞
31.5
30
*
N03AX16
ATC
pregabalin; oral
3.7
31.4
158
519
7378X
ICD-9 Finland
Curvature of spine, Other curvatures of spine
+∞
30.4
29
*
M54.5
ICD-10 Finland
Low back pain
3.1
30.0
203
830
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
47.4
29.9
36
8
M43.8
ICD-10 Finland
Other specified deforming dorsopathies
+∞
29.4
28
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.5
27.3
85
173
M47.9
ICD-10 Finland
Spondylosis, unspecified
64.9
27.2
31
5
N06AX21
ATC
duloxetine; oral
4.8
26.6
94
220
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
26.2
25
*
M54.4
ICD-10 Finland
Lumbago with sciatica
4.5
25.0
95
239
7328X
ICD-9 Finland
Osteochondropathies, Other specified forms of osteochondropathy[OSTEOCHONDROPATHIAE ALIA DEFINITA]
+∞
24.1
23
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
20.4
22.3
33
17
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.2
21.9
70
146
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.9
20.8
53
83
L03
ICPC
Low back symptom/complaint
2.7
18.4
141
599
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
45.4
18.3
22
5
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
11.1
18.1
34
32
7231A
ICD-9 Finland
Other disorders of cervical region, Cervicalgia
+∞
16.7
16
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
16.7
16
*
71798
ICD-8 Finland
Other nonarticular rheumatism, Other muscular rheumatism, fibrositis and myalgia
48.8
16.1
19
*
7329X
ICD-9 Finland
Osteochondropathies, Unspecified osteochondropathy
+∞
15.7
15
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
87.2
15.6
17
*
M47.82
ICD-10 Finland
Other spondylosis, cervical region
14.2
15.6
26
19
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
14.4
15.1
25
18
M03BX02
ATC
tizanidine; oral
1.9
14.7
392
2853
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
14.7
229
1358
M41.8
ICD-10 Finland
Other forms of scoliosis
+∞
14.6
14
*
72898
ICD-8 Finland
Vertebrogenic pain syndrome, Alia definita
+∞
14.6
14
*
N02AC04
ATC
dextropropoxyphene; oral
7.8
14.6
33
44
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.0
14.4
35
52
N02AA05
ATC
oxycodone; systemic
3.0
14.3
86
313
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
76.8
13.6
15
*
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
13.6
13
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
13.5
163
865
N06AA09
ATC
amitriptyline; systemic
3.4
12.9
63
197
M54.6
ICD-10 Finland
Pain in thoracic spine
4.9
12.6
41
88
73500
ICD-8 Finland
NA
+∞
12.5
12
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
12.5
12
*
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
12.5
12
*
N05BA04
ATC
oxazepam; oral
2.1
12.2
163
898
J01MA02
ATC
ciprofloxacin; systemic
1.9
12.2
236
1500
SPAT1229
SPAT
Assessment of need for aid
3.6
12.1
55
163
M01AB55
ATC
diclofenac, combinations; oral
3.8
12.0
51
143
M41
ICD-10 Finland
Scoliosis
47.6
11.9
14
*
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
15.0
11.8
19
13
M54.3
ICD-10 Finland
Sciatica
6.7
11.7
29
45
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
11.6
100
448
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.2
11.5
61
203
7245A
ICD-9 Finland
Other and unspecified disorders of back, Backache, unspecified
+∞
11.5
11
*
N05CF01
ATC
zopiclone; oral
1.9
11.5
203
1243
H02AB06
ATC
prednisolone; systemic
1.8
11.4
283
1943
M54.1
ICD-10 Finland
Radiculopathy
10.8
11.3
21
20
L86
ICPC
Back syndrome with radiating pain
5.0
11.3
36
76
M50.3
ICD-10 Finland
Other cervical disc degeneration
17.4
11.2
17
10
N06AX11
ATC
mirtazapine; oral
1.9
10.9
199
1228
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
10.8
48
140
R52.2
ICD-10 Finland
Other chronic pain
6.5
10.7
27
43
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
21.9
10.7
15
7
R06.0
ICD-10 Finland
Dyspnoea
2.1
10.7
136
728
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
8.7
10.6
22
26
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.0
10.6
62
222
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
10.4
10
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
10.4
10
*
N06AX16
ATC
venlafaxine; oral
2.4
10.4
95
439
M01AH02
ATC
rofecoxib; oral
2.7
10.4
73
293
M79.6
ICD-10 Finland
Pain in limb
1.8
10.4
205
1298
L02
ICPC
Back symptom/complaint
3.0
10.3
59
207
A02BA02
ATC
ranitidine; systemic
2.2
10.2
115
583
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
8.1
10.2
22
28
M01AH05
ATC
etoricoxib; oral
1.7
10.2
358
2706
L29
ICPC
Musculoskeletal sympt/complt other
3.2
10.1
52
170
R03AC02
ATC
salbutamol; inhalant
1.7
10.0
326
2403
72800
ICD-8 Finland
Vertebrogenic pain syndrome, Cervicalgia
40.7
10.0
12
*
L17
ICPC
Foot/toe symptom/complaint
2.0
9.9
138
767
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
12.4
9.9
17
14
M01AE51
ATC
ibuprofen, combinations; systemic
12.4
9.9
17
14
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
12.4
9.9
17
14
A02BC05
ATC
esomeprazole; systemic
1.8
9.9
242
1635
L28
ICPC
Limited function/disability (L)
2.4
9.8
86
390
9359
FHL
Other measure in this category
55.8
9.7
11
*
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
101.4
9.4
10
*
M41.3
ICD-10 Finland
Thoracogenic scoliosis
101.4
9.4
10
*
M41.5
ICD-10 Finland
Other secondary scoliosis
+∞
9.4
9
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
9.4
9
*
71310
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis cervicalis
+∞
9.4
9
*
71312
ICD-8 Finland
Osteo-arthritis and allied conditions, Spondylarthritis lumbalis sive lumbosacralis
+∞
9.4
9
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
9.3
139
790
R07.3
ICD-10 Finland
Other chest pain
2.8
9.3
59
222
R51.80
ICD-10 Finland
Headache
2.3
9.0
88
419
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.0
8.8
125
697
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.5
8.8
25
47
SPAT1240
SPAT
Therapeutic discussion
2.5
8.8
69
295
AA1AD
NOMESCO Finland
CT of head and brain
2.0
8.7
124
692
A02BC03
ATC
lansoprazole; oral
1.8
8.6
167
1038
A02BC01
ATC
omeprazole; systemic
1.8
8.6
161
990
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
8.6
170
1064
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
8.6
260
1850
72850
ICD-8 Finland
Vertebrogenic pain syndrome, Pain in thoracic spine
+∞
8.3
8
*
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
8.3
8
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
8.3
8
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
8.2
201
1340
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
8.2
62
259
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
8.1
216
1476
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.9
7.8
24
50
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
7.8
85
426
P03
ICPC
Feeling depressed
2.5
7.7
59
247
71300
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) coxae
45.5
7.7
9
*
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
45.5
7.7
9
*
J01DA01
ATC
[U] cefalexin; systemic
1.6
7.7
395
3192
SPAT1260
SPAT
Consultation of another employee
2.0
7.7
98
522
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.6
7.6
53
212
R52.1
ICD-10 Finland
Chronic intractable pain
25.3
7.6
10
*
A02BC02
ATC
pantoprazole; systemic
1.6
7.5
377
3022
M79.7
ICD-10 Finland
Fibromyalgia
4.9
7.5
23
48
M03BX01
ATC
baclofen; systemic
7.2
7.5
17
24
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
81.0
7.4
8
*
9193
FHL
Spondylodesis (also includes correction)
+∞
7.3
7
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
7.3
7
*
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
7.3
7
*
M01AX17
ATC
nimesulide; oral
1.8
7.3
133
809
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.2
214
1501
A02BA04
ATC
nizatidine; systemic
2.6
7.1
49
196
N03AE01
ATC
clonazepam; systemic
3.3
7.0
34
108
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.0
104
586
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.0
7.0
21
43
SPAT1301
SPAT
No procedures
1.7
7.0
162
1055
M01AB05
ATC
diclofenac; systemic, rectal
1.6
7.0
396
3240
M01AH01
ATC
celecoxib; oral (coxibs)
2.0
6.9
96
528
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
6.2
6.8
17
28
1220
FHL
Arthroscopy
3.2
6.7
33
107
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.7
98
554
SPAT1263
SPAT
Sampling
1.6
6.6
235
1715
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
6.6
70
345
N06AB04
ATC
citalopram; systemic
1.7
6.6
133
834
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.9
6.5
25
66
N06AX03
ATC
mianserin; oral
3.3
6.5
30
93
9211
FHL
Exploration or removal of diskusprolapse
70.5
6.4
7
*
J01EA01
ATC
trimethoprim; systemic
1.7
6.4
158
1048
M25.5
ICD-10 Finland
Pain in joint
1.7
6.4
159
1059
M70.6
ICD-10 Finland
Trochanteric bursitis
2.2
6.3
63
301
M01AC06
ATC
meloxicam; systemic, rectal
1.6
6.3
195
1370
N05BA01
ATC
diazepam; systemic, rectal
2.0
6.3
76
398
2309
FHL
Other measure in this category
+∞
6.3
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.3
6
*
9183
FHL
Posterolateral spondylodesis
+∞
6.3
6
*
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
6.3
6
*
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
+∞
6.3
6
*
7233A
ICD-9 Finland
Other disorders of cervical region, Cervicobrachial syndrome (diffuse)
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.2
519
4589
N05AH04
ATC
quetiapine; oral
1.9
6.2
96
553
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
7.8
6.1
13
17
A06AD11
ATC
lactulose; oral
2.1
6.1
71
366
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.1
72
372
NF1AA
NOMESCO Finland
Hip X-ray examination
2.6
6.0
41
164
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
6.0
137
886
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
316
2183
1.79
12.90
6.4
5.4
1.2
1.2
mmol/l
1.23
286
1980
240
1565
1.80
11.64
2.6
2.3
57.5
58.5
u/l
0.08
226
1461
223
1452
1.77
10.72
2.8
2.0
180.5
188.5
u/l
0.07
211
1356
363
2738
1.65
9.90
6.6
6.1
10.5
11.1
umol/l
0.40
349
2592
334
2473
1.65
9.75
7.3
6.2
1.2
1.2
mmol/l
1.34
279
2063
192
1242
1.74
9.24
3.3
3.1
864.7
1246.8
ng/l
0.97
155
1043
505
4199
1.66
8.89
8.7
6.9
76.0
76.5
u/l
0.13
483
3952
426
3422
1.59
8.41
5.7
3.7
12.8
2919.7
e6/l
—
5
59
147
904
1.78
8.35
1.4
1.2
20.7
12.0
u/ml
0.56
60
357
489
4070
1.61
8.21
5.3
3.5
10.6
11.4
mm/h
0.74
455
3778
304
2299
1.55
7.54
2.5
2.1
76.5
76.1
nmol/l
0.08
268
2109
241
1734
1.58
7.41
3.7
2.8
—
—
—
0
0
150
971
1.69
7.01
1.4
1.2
39.6
32.1
iu/ml
0.30
59
314
365
2904
1.52
6.99
5.8
4.1
6.6
6.7
mmol/l
0.37
345
2715
284
2157
1.52
6.70
5.3
4.4
35.8
36.0
g/l
0.25
257
2009
180
1245
1.59
6.42
1.4
1.2
3.9
1.6
u/ml
0.62
49
330
136
881
1.67
6.30
3.9
3.1
277.0
354.7
ng/l
0.21
96
608
115
715
1.72
6.20
1.8
1.8
—
—
—
0
0
84
476
1.86
6.17
1.8
1.7
—
—
—
0
0
185
1300
1.57
6.13
3.3
2.6
0.3
0.4
e6/l
0.68
141
954
83
471
1.86
6.07
1.8
1.7
—
—
—
0
0
102
630
1.72
5.62
2.8
2.3
24.0
23.0
%
0.31
84
540
161
1118
1.57
5.57
1.6
1.7
447.4
27885038.9
pmol/l
1.28
135
936
326
2625
1.44
5.40
4.8
3.1
0.0
0.0
estimate
0.00
60
478
302
2398
1.44
5.39
4.2
3.7
—
—
—
0
0
235
1781
1.47
5.35
3.7
3.3
2.3
2.4
mmol/l
0.78
207
1598
244
1863
1.47
5.35
3.8
3.1
20.1
60.6
ng/l
1.20
165
1146
328
2664
1.42
5.09
4.7
3.1
0.0
0.0
estimate
0.80
60
468
107
688
1.65
5.06
2.7
2.2
2.4
2.4
g/l
0.29
99
637
184
1350
1.49
4.87
5.6
3.3
0.0
0.0
estimate
0.69
62
476
183
1347
1.48
4.75
3.0
2.4
2822.8
4863.4
umol/l
0.34
156
1195
33
148
2.29
4.57
1.2
1.3
246.8
305.2
ug/g
0.95
17
84
323
2656
1.39
4.49
6.4
4.4
0.0
0.0
estimate
0.41
61
488
622
5743
1.57
4.43
17.3
11.2
22.2
22.1
mg/l
0.01
509
4417
635
5900
1.60
4.30
18.0
12.5
139.6
139.7
mmol/l
0.63
620
5733
83
522
1.67
4.28
24.0
19.5
1.4
1.2
inr
—
10
84
33
153
2.21
4.24
1.2
1.1
—
—
—
0
0
17
57
3.03
4.14
1.3
1.2
—
—
—
0
0
370
3146
1.36
4.03
11.1
9.3
4.1
4.0
e9/l
0.20
334
2757
261
2102
1.38
4.01
5.0
3.2
—
—
—
0
0
89
581
1.61
3.97
2.6
2.5
9.9
7.1
umol/l
0.42
72
495
110
756
1.54
3.93
2.8
2.2
13.8
13.2
umol/l
0.42
101
696
635
5929
1.56
3.87
18.3
12.6
3.9
3.9
mmol/l
0.61
619
5751
26
114
2.33
3.82
1.6
1.4
—
—
—
0
0
149
1098
1.45
3.78
5.2
3.3
1.0
1.0
kg/l
0.56
23
154
91
611
1.56
3.61
6.4
5.2
1.0
1.0
mmol/l
0.39
81
572
72
460
1.63
3.52
2.2
2.0
65.6
37.4
u/l
0.40
62
397
149
1113
1.43
3.50
1.5
1.4
20.6
21.3
nmol/l
0.20
127
945
56
336
1.72
3.46
1.8
1.6
—
—
—
0
0
230
1854
1.35
3.41
3.8
3.2
29.4
30.7
u/l
0.31
217
1776
583
5391
1.41
3.36
5.7
4.6
1.9
2.1
mu/l
0.45
535
4991
21
89
2.40
3.34
1.5
1.5
—
—
—
0
0
33
170
1.99
3.29
2.4
4.1
24.4
25.1
mmol/l
1.14
27
161
27
129
2.14
3.27
2.7
1.5
—
—
—
0
0
75
494
1.58
3.24
3.1
4.4
14.7
8.6
ug/l
0.29
53
388
45
259
1.79
3.22
1.6
1.4
—
—
—
0
0
156
1192
1.39
3.21
2.1
2.1
—
—
—
0
0
502
4549
1.33
3.18
4.8
4.0
14.7
14.5
pmol/l
0.55
463
4207
157
1205
1.39
3.14
1.7
1.7
1.0
1.1
mg/l
0.02
111
900
72
475
1.57
3.10
10.5
7.8
1.6
1.3
mmol/l
0.53
61
380
30
153
2.00
3.09
1.2
1.1
—
—
—
0
0
25
120
2.12
3.01
1.3
1.2
—
—
—
0
0
58
370
1.62
2.88
3.0
3.3
76.9
76.1
ng/l
0.04
50
322
239
1982
1.31
2.83
2.1
1.8
97.4
97.9
pmol/l
0.05
120
1044
36
203
1.81
2.78
3.2
2.8
24.5
23.9
mmol/l
0.39
28
186
33
181
1.86
2.78
2.2
1.9
1318.1
2268.4
u/l
0.31
11
67
69
465
1.53
2.73
2.1
2.1
0.2
0.2
g/l
0.94
62
445
18
79
2.31
2.69
1.3
1.7
—
—
—
0
0
81
568
1.48
2.66
8.7
5.5
—
—
—
0
0
187
1511
1.32
2.65
3.0
3.3
7.2
7.5
mmol/l
0.51
157
1285
5
7
7.18
2.55
3.0
1.4
—
—
—
0
0
6
11
5.49
2.55
1.5
1.1
—
—
—
0
0
62
415
1.54
2.54
3.6
2.9
3.0
1.8
mmol/l
1.92
53
326
108
808
1.40
2.51
5.0
3.3
0.8
0.8
mmol/l
0.22
100
765
18
82
2.23
2.49
1.7
1.5
—
—
—
0
0
42
257
1.67
2.48
2.2
3.8
1.4
2.1
mmol/l
1.05
31
201
24
124
1.97
2.43
1.6
1.7
—
—
—
0
0
153
1219
1.32
2.38
2.6
2.0
3.0
3.0
mg/l
0.11
133
1039
23
118
1.98
2.38
1.6
1.7
—
—
—
0
0
5
8
6.28
2.37
2.0
2.9
—
—
—
0
0
116
889
1.36
2.33
3.3
2.7
2.4
2.4
mmol/l
0.14
105
792
22
113
1.98
2.27
1.3
1.5
—
—
—
0
0
14
60
2.36
2.23
1.4
1.7
—
—
—
0
0
5
9
5.58
2.21
1.2
1.6
—
—
—
0
0
98
742
1.37
2.13
3.0
2.3
0.6
1.2
e6/l
3.70
54
395
46
304
1.55
2.03
1.2
1.5
—
—
—
0
0
25
140
1.81
2.03
1.7
1.2
1.9
13.9
u/ml
—
6
25
108
838
1.34
2.02
2.0
1.7
1217.0
1172.2
nmol/l
0.20
82
630
526
4913
1.25
2.01
19.9
14.1
13.8
13.6
%
0.96
514
4814
59
414
1.46
1.97
3.7
3.4
1.2
1.2
mmol/l
0.66
50
355
15
71
2.14
1.93
1.5
1.6
—
—
—
0
0
73
536
1.40
1.92
2.0
1.7
—
—
—
0
0
18
92
1.98
1.91
1.8
1.7
—
—
—
0
0
8
29
2.78
1.79
3.0
2.2
—
—
—
0
0
31
193
1.63
1.77
2.1
1.6
—
—
—
0
0
92
712
1.33
1.76
3.2
2.4
2.7
3.4
e6/l
0.35
46
369
80
607
1.36
1.75
2.0
1.8
—
—
—
0
0
12
54
2.24
1.74
2.0
1.7
—
—
—
0
0
12
54
2.24
1.74
1.1
1.4
—
0.6
nmol/l
—
0
5
28
172
1.65
1.69
1.9
2.1
—
—
—
0
0
63
462
1.40
1.69
2.1
1.9
348.9
381.5
nmol/l
0.45
54
432
29
180
1.64
1.69
1.6
1.9
1.6
1.5
g/l
0.33
23
157
25
150
1.69
1.65
1.5
1.6
—
—
—
0
0
13
63
2.08
1.60
14.3
5.8
10.9
10.6
mg/l
0.09
13
57
56
407
1.41
1.59
2.2
2.4
72.6
67.8
ml/min/173m2
0.54
26
160
107
861
1.28
1.56
4.0
3.6
20.3
21.5
%
0.32
40
370
282
2518
1.20
1.55
3.2
2.6
99.3
105.2
ug/l
0.31
264
2349
15
78
1.94
1.55
1.5
2.4
15.8
16.6
%
—
6
45
22
130
1.71
1.54
3.5
3.7
3.6
3.9
mmol/l
1.77
22
116
8
33
2.44
1.54
1.0
1.0
—
—
—
0
0
44
309
1.45
1.51
1.1
1.0
—
—
—
0
0
6
21
2.87
1.51
1.2
1.7
—
—
—
0
0
6
21
2.87
1.51
1.2
1.7
—
—
—
0
0
50
363
1.41
1.45
2.2
2.2
36.6
7.5
ug/l
0.88
43
320
60
451
1.36
1.42
1.1
1.2
124.8
142.7
iu/ml
0.16
20
200
590
5656
1.23
1.38
4.5
4.0
5.8
5.8
mmol/l
0.63
547
5203
9
41
2.21
1.37
1.8
1.8
—
—
—
0
0
5
17
2.95
1.36
1.2
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
120
1.69
1.35
2.5
2.7
0.4
0.4
u/ml
—
10
65
18
106
1.72
1.30
1.1
1.7
—
—
—
0
0
5
18
2.79
1.28
1.2
2.3
—
—
—
0
0
10
48
2.10
1.28
1.2
1.7
—
—
—
0
0
10
48
2.10
1.28
1.2
1.7
—
—
—
0
0
10
48
2.10
1.28
1.2
1.7
—
—
—
0
0
53
695
0.74
1.28
1.7
1.8
—
—
—
0
0
11
55
2.02
1.28
1.5
1.2
—
—
—
0
0
33
229
1.46
1.24
2.1
1.7
—
—
—
0
0
15
85
1.78
1.23
1.5
1.3
101.4
100.8
u/ml
—
5
18
27
180
1.52
1.22
2.4
3.6
1342.3
1820.0
u/ml
0.11
19
157
66
518
1.30
1.20
4.0
2.8
—
—
—
0
0
16
94
1.72
1.18
1.6
1.2
—
—
—
0
0
16
94
1.72
1.18
1.6
1.2
—
—
—
0
0
5
20
2.51
1.15
2.0
1.8
—
—
—
0
0
435
4091
1.16
1.15
3.4
2.8
41.1
45.4
u/l
0.77
409
3857
16
95
1.70
1.14
1.3
2.0
114.5
130.9
g/l
1.13
11
78
12
65
1.86
1.14
2.7
2.2
13.3
67.3
u/ml
0.41
12
60
30
209
1.45
1.12
4.4
3.1
42.8
48.9
%
0.89
30
203
7
31
2.27
1.10
2.1
1.6
—
—
—
0
0
5
21
2.39
1.09
1.6
1.0
199.4
129.2
iu/ml
—
5
21
170
1495
1.18
1.08
3.9
4.0
4.3
7.6
mg/mmol
1.45
112
940
7
33
2.13
1.05
3.1
2.2
573.6
458.3
e6/l
—
7
27
125
1077
1.19
1.01
5.1
4.2
3.4
2.4
ug/l
0.39
108
970
16
99
1.63
1.00
1.3
1.2
263.1
318.5
u/ml
0.50
11
56
5
23
2.18
0.98
1.6
1.2
—
—
—
0
0
5
23
2.18
0.98
1.4
2.0
—
—
—
0
0
645
6289
1.22
0.97
12.1
9.0
25.3
25.6
u/l
0.19
629
6088
47
364
1.31
0.97
2.4
2.9
66.6
67.3
g/l
0.23
40
343
51
400
1.30
0.96
11.8
7.3
9.4
9.0
mmol/l
0.13
51
378
9
51
1.77
0.94
1.8
1.7
—
—
—
0
0
6
120
0.50
0.94
1.0
1.3
—
—
—
0
0
6
120
0.50
0.94
1.0
1.3
—
—
—
0
0
6
120
0.50
0.94
1.0
1.3
—
—
—
0
0
6
120
0.50
0.94
1.0
1.3
—
—
—
0
0
47
367
1.30
0.92
1.3
1.3
75.0
212.6
u/ml
2.52
42
338
13
78
1.68
0.92
1.7
1.5
—
—
—
0
0
6
28
2.15
0.91
1.2
1.3
—
101.4
—
0
7
23
160
1.45
0.90
1.5
1.7
—
86.7
—
0
6
8
42
1.91
0.88
1.4
1.1
—
—
—
0
0
8
42
1.91
0.88
1.4
1.1
—
—
—
0
0
21
144
1.47
0.88
1.1
1.3
—
—
—
0
0
10
56
1.80
0.88
1.1
1.1
—
—
—
0
0
8
43
1.87
0.87
1.4
1.1
—
—
—
0
0
8
43
1.87
0.87
1.4
1.1
—
—
—
0
0
8
43
1.87
0.87
1.4
1.1
—
—
—
0
0
19
129
1.49
0.84
1.3
1.4
27.4
29.1
u/l
0.09
14
110
10
57
1.76
0.84
1.1
1.1
—
—
—
0
0
675
6628
1.25
0.83
24.2
16.9
134.0
135.4
g/l
1.91
669
6526
6
32
1.88
0.82
1.3
1.6
—
—
—
0
0
54
443
1.24
0.74
1.6
1.3
26.4
31.0
iu/l
0.46
48
387
9
54
1.67
0.74
1.8
1.7
—
—
—
0
0
5
24
2.09
0.74
1.0
1.0
—
—
—
0
0
9
55
1.64
0.73
1.2
1.5
—
—
—
0
0
16
109
1.48
0.71
1.3
1.2
—
—
—
0
0
164
1489
1.13
0.69
1.8
1.6
1.3
1.4
mmol/l
0.53
142
1262
11
70
1.58
0.65
1.1
1.5
—
—
—
0
0
11
70
1.58
0.65
1.1
1.5
—
—
—
0
0
7
44
1.60
0.65
1.6
1.2
—
—
—
0
0
5
29
1.73
0.64
1.4
1.9
—
—
—
0
0
39
316
1.25
0.62
2.4
1.6
—
—
—
0
0
11
71
1.56
0.62
1.1
1.5
—
—
—
0
0
5
30
1.67
0.61
1.2
1.0
—
—
—
0
0
8
50
1.61
0.61
2.0
3.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
32.8
—
0
22
10
64
1.57
0.59
1.1
1.5
—
—
—
0
0
81
710
1.16
0.58
1.8
1.8
1.4
1.4
%
0.00
67
643
6
36
1.67
0.56
1.3
1.2
—
70.0
—
0
6
6
38
1.58
0.54
2.3
3.4
—
—
—
0
0
36
296
1.23
0.52
2.9
2.3
12.7
12.7
nmol/l
0.01
31
275
9
63
1.43
0.52
1.4
3.8
19.8
76.8
u/ml
—
9
63
77
681
1.15
0.50
4.6
3.9
32.6
31.8
%
0.25
51
470
25
199
1.27
0.48
1.7
2.1
—
—
—
0
0
13
93
1.41
0.48
1.3
3.0
7.8
8.2
kpa
0.34
13
87
13
93
1.41
0.48
1.1
1.2
1.4
4.3
u/ml
—
5
31
10
68
1.48
0.47
1.1
1.5
—
—
—
0
0
10
68
1.48
0.47
1.1
1.5
—
—
—
0
0
10
68
1.48
0.47
1.1
1.5
—
—
—
0
0
12
85
1.42
0.47
4.0
3.3
—
3206.4
—
0
8
7
48
1.46
0.47
1.1
1.0
—
—
—
0
0
10
69
1.46
0.44
1.5
1.6
—
—
—
0
0
10
69
1.46
0.44
1.1
1.5
—
—
—
0
0
29
239
1.22
0.43
2.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.4
1.3
333.9
311.0
pmol/l
—
8
45
564
5534
1.09
0.39
18.2
12.1
39.3
40.0
%
0.99
417
4294
5
35
1.43
0.39
1.4
1.5
—
—
—
0
0
544
5331
1.08
0.39
5.8
5.0
39.4
39.2
mmol/mol
0.13
506
4982
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
12
89
1.35
0.38
1.3
1.4
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
117
1085
1.09
0.36
1.5
1.5
—
—
—
0
0
23
190
1.22
0.35
1.2
1.4
172.4
244.1
miu/ml
—
5
96
6
43
1.40
0.35
1.3
1.2
—
—
—
0
0
71
644
1.11
0.34
3.2
2.6
0.6
0.8
ug/l
1.66
42
380
18
145
1.25
0.34
2.1
2.7
—
—
—
0
0
13
100
1.31
0.33
2.1
1.4
—
—
—
0
0
10
74
1.36
0.32
1.0
1.1
—
—
—
0
0
11
83
1.33
0.32
1.2
1.3
—
—
—
0
0
10
130
0.77
0.29
1.4
1.3
—
—
—
0
0
12
94
1.28
0.28
2.3
1.8
172.1
217.5
pmol/l
0.80
12
89
10
77
1.30
0.26
1.1
1.1
—
—
—
0
0
122
1158
1.06
0.23
1.7
1.4
—
—
—
0
0
5
39
1.28
0.23
2.0
1.2
2.0
2.0
mmol/l
—
5
39
21
181
1.16
0.22
1.6
1.9
—
—
—
0
0
7
91
0.77
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.3
—
0.9
—
0
10
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
6
49
1.23
0.20
1.3
1.2
—
—
—
0
0
410
4030
1.04
0.19
3.2
3.1
—
—
—
0
0
5
66
0.76
0.17
1.0
1.3
—
—
—
0
0
12
101
1.19
0.16
1.2
1.2
1.3
3.9
u/ml
—
7
39
16
139
1.15
0.16
1.4
1.2
—
—
—
0
0
564
5588
1.04
0.16
15.0
10.3
84.5
83.6
ml/min/173m2
0.50
472
4601
18
159
1.14
0.15
1.7
1.9
8.6
10.9
g/l
2.25
13
141
26
284
0.91
0.13
1.9
1.4
—
—
—
0
0
11
94
1.17
0.13
3.8
2.9
3.5
4.3
e9/l
0.58
11
94
18
161
1.12
0.13
1.7
1.9
3.4
3.1
g/l
0.40
13
130
28
258
1.09
0.12
1.5
1.7
—
—
—
0
0
14
158
0.88
0.12
2.6
2.1
3.1
6.4
iu/l
—
6
61
605
6012
1.04
0.12
4.7
4.3
2.8
2.9
mmol/l
1.02
560
5594
26
241
1.08
0.10
1.3
1.5
—
—
—
0
0
19
173
1.10
0.10
1.7
1.9
7.7
7.4
g/l
0.19
13
132
19
173
1.10
0.10
1.7
1.9
—
—
—
0
0
19
173
1.10
0.10
1.7
1.9
3.4
3.8
g/l
0.69
13
125
568
5713
0.97
0.09
3.9
3.6
1.3
1.3
mmol/l
0.07
528
5300
17
155
1.10
0.09
2.7
2.3
4.0
3.6
g/l
0.34
17
147
16
146
1.10
0.08
1.0
1.1
—
—
—
0
0
595
5922
1.03
0.08
4.4
4.0
4.7
4.8
mmol/l
1.46
556
5547
10
89
1.13
0.07
1.1
1.1
—
—
—
0
0
17
158
1.08
0.06
1.1
1.2
—
—
—
0
0
18
192
0.94
0.05
1.2
1.4
—
—
—
0
0
11
100
1.10
0.05
4.0
3.2
55.1
56.9
%
0.14
11
100
591
5903
1.01
0.00
4.4
4.0
1.5
1.5
mmol/l
0.77
551
5497
10
96
1.04
0.00
1.2
1.1
—
—
—
0
0
13
127
1.02
0.00
2.5
2.3
29.6
119.6
ug/min
—
8
81
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
68.6
—
0
7
26
260
1.00
0.00
1.8
1.8
3.6
3.1
mg/l
0.20
21
189
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
5.3
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
5
52
0.96
0.00
1.2
1.7
1.0
1.0
g/l
—
5
52
0
9
0.00
0.00
0.0
2.3
—
1.2
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
39.3
—
0
6
0
8
0.00
0.00
0.0
1.1
—
101.2
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_DEFORMDORSONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DEFORMDORSONAS | 1.568 [1.23, 2.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.519 |
During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 546 females with M13_DEFORMDORSONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DEFORMDORSONAS | 1.136 [0.78, 1.64] | 0.5 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 373 males with M13_DEFORMDORSONAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_DEFORMDORSONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.208% |
| 5 | 1.08% | 1.234% |
| 10 | 2.375% | 3.06% |
| 15 | 4.839% | 5.699% |
| 20 | 8.709% | 9.628% |
Relationships between endpoints
↥Index endpoint: M13_DEFORMDORSONAS – Other specified/unspecified deforming dorsopathies
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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