Torticollis

M13_TORTICOLLIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M43.6
  • Hospital discharge: ICD-9 7235
  • Hospital discharge: ICD-8 7172
  • Cause of death: ICD-10 M43.6
  • Cause of death: ICD-9 7235
  • Cause of death: ICD-8 7172

2 out of 7 registries used, show all original rules.

685

4. Check minimum number of events

None

685

5. Include endpoints

None

685

6. Filter based on genotype QC (FinnGen only)

661

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M43
Name in latin
Torticollis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9116 4207 4879
Only index persons 7518 3531 3987
Unadjusted period prevalence (%)
Whole population 0.13 0.12 0.14
Only index persons 0.14 0.13 0.15
Median age at first event (years)
Whole population 10.56 12.33 8.83
Only index persons 12.61 14.72 10.74

-FinnGen-

Key figures

All Female Male
Number of individuals 661 388 273
Unadjusted period prevalence (%) 0.13 0.14 0.13
Median age at first event (years) 24.70 26.33 22.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
685
Matched controls
6850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M43.6
ICD-10 Finland
Torticollis
786.9
307.7
444
16
71720
ICD-8 Finland
Other nonarticular rheumatism, Torticollis not specified as congential, pyschogenic or traumatic
+∞
197.8
180
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
19.9
107.7
86
49
G24.3
ICD-10 Finland
Spasmodic torticollis
31.2
78.6
52
18
7235A
ICD-9 Finland
Other disorders of cervical region, Torticollis, unspecified
+∞
75.4
71
*
N03AX16
ATC
[U] pregabalin
4.5
57.1
168
459
M48.0
ICD-10 Finland
Spinal stenosis
21.8
57.0
43
21
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
12.8
48.4
48
40
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
20.5
47.9
37
19
N03AX12
ATC
[U] gabapentin; oral
5.0
47.8
114
261
N03AE01
ATC
clonazepam; systemic
7.2
47.7
75
115
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
15.5
46.3
41
28
M54.5
ICD-10 Finland
Low back pain
3.1
41.1
238
997
M03BX02
ATC
tizanidine; oral
3.0
39.8
452
2708
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.7
39.5
78
150
M54.4
ICD-10 Finland
Lumbago with sciatica
4.4
38.9
109
282
M03BC01
ATC
orphenadrine (citrate); systemic
3.3
38.4
185
692
M54.9
ICD-10 Finland
Dorsalgia, unspecified
4.8
37.5
91
210
N02AX02
ATC
tramadol; systemic, rectal
2.9
37.4
271
1274
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
10.1
35.4
41
43
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
7.2
32.7
50
74
M54.2
ICD-10 Finland
Cervicalgia
4.7
28.3
69
159
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
47.8
26.7
32
7
M54.3
ICD-10 Finland
Sciatica
7.2
25.7
39
57
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
9.4
23.1
28
31
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
19.9
19
*
L01
ICPC
Neck symptom/complaint
2.7
19.7
118
485
L03
ICPC
Low back symptom/complaint
2.3
19.3
175
874
N06AA09
ATC
amitriptyline; systemic
3.8
18.9
60
168
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
17.7
253
1508
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
17.5
166
842
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
17.4
265
1615
N06AX21
ATC
duloxetine; oral
3.1
17.0
76
265
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.1
16.9
77
272
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
16.7
16
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
28.3
16.6
22
8
M01AE02
ATC
naproxen; oral, rectal
2.0
16.3
407
2923
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
15.9
162
843
R51.80
ICD-10 Finland
Headache
2.4
15.8
126
591
M47.9
ICD-10 Finland
Spondylosis, unspecified
87.1
15.6
17
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
15.2
261
1640
A02BC01
ATC
omeprazole; systemic
2.2
15.0
163
867
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
14.9
171
929
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
16.9
14.9
23
14
M01AB05
ATC
diclofenac; systemic, rectal
1.9
14.5
399
2909
G44.2
ICD-10 Finland
Tension-type headache
2.5
14.4
99
432
A02BC02
ATC
pantoprazole; systemic
1.9
14.3
392
2849
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
14.3
140
714
M79.1
ICD-10 Finland
Myalgia
2.4
14.1
107
489
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
30.7
13.9
18
6
M03BC51
ATC
orphenadrine, combinations; systemic
2.1
13.4
165
917
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
13.3
56
188
M79.6
ICD-10 Finland
Pain in limb
1.9
12.9
248
1598
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
12.8
45
135
N05BA01
ATC
diazepam; systemic, rectal
2.5
12.6
89
393
AA1AD
NOMESCO Finland
CT of head and brain
2.1
12.5
139
741
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
12.3
249
1626
N02BF02
ATC
pregabalin; oral
3.9
12.3
36
95
N02AA05
ATC
oxycodone; systemic
2.5
12.1
80
342
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
12.0
133
709
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
47.5
11.9
14
*
H02AB06
ATC
prednisolone; systemic
1.8
11.8
276
1877
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
122.0
11.5
12
*
R25.2
ICD-10 Finland
Cramp and spasm
5.5
11.4
22
41
M47.82
ICD-10 Finland
Other spondylosis, cervical region
15.4
11.4
18
12
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
11.3
198
1230
R07.3
ICD-10 Finland
Other chest pain
2.7
11.1
63
250
R52.9
ICD-10 Finland
Pain, unspecified
2.7
11.1
63
250
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
10.9
149
852
N06AB04
ATC
citalopram; systemic
2.0
10.8
125
674
M54.6
ICD-10 Finland
Pain in thoracic spine
3.2
10.8
44
145
M50.3
ICD-10 Finland
Other cervical disc degeneration
21.9
10.7
15
7
A07AA02
ATC
nystatin; oral
3.5
10.7
37
110
R03AC02
ATC
salbutamol; inhalant
1.7
10.6
363
2724
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.6
10.6
61
244
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
10.5
117
623
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
10.4
10
*
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
3.6
10.4
35
102
M54.1
ICD-10 Finland
Radiculopathy
9.8
10.3
20
21
SPAT1229
SPAT
Assessment of need for aid
3.4
10.3
37
113
S80.0
ICD-10 Finland
Contusion of knee
2.6
10.2
62
254
M01AC06
ATC
meloxicam; systemic, rectal
1.8
10.2
185
1157
N05AH04
ATC
quetiapine; oral
2.0
10.2
128
710
N05BA04
ATC
oxazepam; oral
1.9
10.2
158
942
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.7
10.2
55
213
XA402
NOMESCO Finland
ENMG
9.3
10.1
20
22
N06AX11
ATC
mirtazapine; oral
1.8
10.0
201
1295
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.7
9.9
31
86
G43.9
ICD-10 Finland
Migraine, unspecified
2.7
9.9
54
210
N02BF01
ATC
gabapentin; oral
3.3
9.9
38
121
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
9.9
100
513
R06.0
ICD-10 Finland
Dyspnoea
1.9
9.8
146
858
J45.1
ICD-10 Finland
Nonallergic asthma
2.7
9.7
52
200
M25.5
ICD-10 Finland
Pain in joint
1.8
9.7
188
1198
NF1AA
NOMESCO Finland
Hip X-ray examination
3.0
9.7
42
144
N02BE01
ATC
paracetamol; systemic, rectal
1.9
9.6
557
4775
C07AA05
ATC
propranolol; systemic
1.9
9.5
144
849
R42
ICD-10 Finland
Dizziness and giddiness
2.0
9.5
116
636
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.8
9.5
29
79
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
12.6
9.4
16
13
M54
ICD-10 Finland
Dorsalgia
2.3
9.4
76
356
R06AE07
ATC
cetirizine; oral
1.7
9.4
291
2107
B01AA03
ATC
warfarin; systemic
2.3
9.3
78
370
N03AX09
ATC
lamotrigine; oral
3.0
9.2
42
148
A02BC05
ATC
esomeprazole; systemic
1.7
9.2
217
1458
W19
ICD-10 Finland
Unspecified fall
2.4
9.2
65
287
L28
ICPC
Limited function/disability (L)
2.2
9.2
78
373
M01AH05
ATC
etoricoxib; oral
1.6
9.0
349
2661
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.6
9.0
30
87
N06AX16
ATC
venlafaxine; oral
2.1
9.0
95
494
J01FF01
ATC
clindamycin; systemic
1.8
9.0
162
1007
A01
ICPC
Pain general/multiple sites
2.5
8.7
56
236
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.9
8.6
19
40
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
10.2
8.6
16
16
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
8.5
112
629
UJF32
NOMESCO Finland
Coloscopy
1.9
8.5
122
706
R52.2
ICD-10 Finland
Other chronic pain
4.0
8.5
24
62
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
8.4
118
677
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
8.3
8
*
J01DA01
ATC
[U] cefalexin
1.6
8.3
376
2956
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.0
8.2
37
130
TAB00
NOMESCO Finland
Lumbar puncture
3.1
8.1
33
109
R52.1
ICD-10 Finland
Chronic intractable pain
33.8
8.1
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
8.1
112
641
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
8.0
150
940
R20.2
ICD-10 Finland
Paraesthesia of skin
2.7
8.0
43
166
M01AH01
ATC
celecoxib; oral
2.1
7.9
78
395
N05CF01
ATC
zopiclone; oral
1.7
7.8
166
1078
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
9.6
7.8
15
16
3AX01, ,
NOMESCO Finland
15.2
7.7
12
8
J01AA02
ATC
doxycycline; systemic
1.6
7.7
438
3606
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.9
7.6
36
130
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.9
7.6
36
130
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.3
7.6
61
285
UJF92
NOMESCO Finland
Capsular endoscopy
4.3
7.5
19
45
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
7.5
127
772
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
7.5
120
718
3338X
ICD-9 Finland
Other extrapyramidal disease and abnormal movement disorders, Fragments of torsion dystonia
80.9
7.4
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.4
274
2041
R03BA05
ATC
fluticasone; inhalant
1.8
7.3
125
761
K30
ICD-10 Finland
Functional dyspepsia
2.1
7.3
66
324
N06AX03
ATC
mianserin; oral
3.1
7.2
30
101
L18
ICPC
Muscle pain
2.9
7.1
32
112
N03AG01
ATC
valproic acid; systemic, rectal
2.6
7.1
42
170
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.1
7.1
69
347
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
4.1
7.1
19
47
M35.7
ICD-10 Finland
Hypermobility syndrome
8.9
7.1
14
16
C07AB07
ATC
bisoprolol; oral
1.6
7.1
215
1525
R06AX11
ATC
astemizole; oral
3.2
7.1
27
86
N05AF03
ATC
chlorprothixene; systemic
3.6
7.0
23
66
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
7.0
301
2307
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
6.8
240
1757
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
6.8
77
410
JAH01
NOMESCO Finland
Laparoscopy
3.0
6.8
30
104
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.6
6.8
38
150
M77.1
ICD-10 Finland
Lateral epicondylitis
2.4
6.8
47
206
R60.9
ICD-10 Finland
Oedema, unspecified
3.1
6.7
28
94
G24.8
ICD-10 Finland
Other dystonia
22.8
6.7
9
*
M45
ICD-10 Finland
Ankylosing spondylitis
22.8
6.7
9
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
6.7
74
392
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.2
6.6
57
274
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.8
6.6
33
123
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.6
91
519
X57
ICD-10 Finland
Unspecified privation
4.2
6.6
17
41
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.9
6.6
19
50
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.5
83
460
C03CA01
ATC
furosemide; systemic
1.8
6.5
113
690
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
5.4
6.5
18
34
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.7
6.5
34
130
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.9
6.5
85
477
M53.2
ICD-10 Finland
Spinal instabilities
70.5
6.4
7
*
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
14.5
6.4
10
7
G43.3
ICD-10 Finland
Complicated migraine
3.8
6.4
19
51
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
8.3
6.4
13
16
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.3
142
931
M54.8
ICD-10 Finland
Other dorsalgia
3.5
6.3
21
61
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
6.3
68
357
A03FA01
ATC
metoclopramide; systemic, rectal
1.7
6.3
119
746
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
+∞
6.3
6
*
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.1
6.3
63
322
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.4
6.2
43
188
A02BC03
ATC
lansoprazole; oral
1.7
6.2
132
854
R52.0
ICD-10 Finland
Acute pain
3.0
6.2
26
88
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
6.2
56
275
G43.8
ICD-10 Finland
Other migraine
3.8
6.1
18
48
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.6
6.1
161
1099
S21
ICPC
Skin texture symptom/complaint
1.9
6.1
81
456
S18
ICPC
Laceration/cut
1.5
6.1
240
1794
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.1
141
932
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.1
339
2721
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.3
6.1
44
197
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
2.7
6.1
32
123
N89
ICPC
Migraine
2.5
6.0
36
147
T81.9
ICD-10 Finland
Unspecified complication of procedure
5.3
6.0
17
33
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.0
467
4003
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
2.4
6.0
39
166

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
273
1805
1.85
13.18
17.2
9.9
1.34
1.20
inr
1.38
80
589
232
1494
1.84
11.94
3.4
3.0
17.04
70.88
ng/l
1.23
138
868
364
2680
1.76
11.86
5.6
4.3
6.56
6.59
mmol/l
0.08
353
2447
320
2295
1.74
11.23
5.9
6.2
10.06
12.07
umol/l
3.09
306
2176
265
1810
1.76
11.00
4.2
4.7
37.03
36.59
g/l
0.61
239
1698
170
1035
1.85
10.25
3.8
3.0
—
—
—
0
0
295
2114
1.69
10.06
7.2
6.5
1.21
1.21
mmol/l
0.31
258
1826
450
3611
1.72
9.97
7.7
6.7
78.99
78.31
u/l
0.11
441
3399
350
2639
1.67
9.73
7.4
5.5
2.13
1.97
e9/l
0.95
320
2362
349
2637
1.66
9.56
7.7
5.9
0.19
0.18
e9/l
0.37
316
2336
237
1624
1.70
9.40
2.0
1.7
93.31
96.81
pmol/l
0.50
132
867
338
2547
1.65
9.25
7.5
5.5
0.58
0.56
e9/l
0.68
300
2223
201
1327
1.73
9.08
2.5
2.3
51.10
60.17
u/l
1.63
193
1233
441
3564
1.67
9.07
4.5
3.3
10.56
9.92
mm/h
0.50
420
3296
65
289
2.38
9.03
4.4
3.0
—
—
—
0
0
337
2549
1.63
9.01
7.6
5.5
0.04
0.04
e9/l
0.02
297
2231
378
2944
1.63
8.96
10.1
8.8
4.13
3.95
e9/l
0.57
330
2555
320
2400
1.63
8.78
7.5
5.9
—
—
—
0
0
265
1899
1.64
8.71
7.7
5.9
1.21
1.22
mmol/l
1.55
243
1764
164
1039
1.76
8.50
3.9
4.0
—
—
—
0
0
273
1982
1.63
8.46
3.6
2.8
6.23
5.90
ph
1.15
24
190
163
1034
1.76
8.40
3.9
3.1
1.01
1.02
kg/l
0.42
23
148
269
1963
1.61
8.07
2.3
2.3
73.26
73.30
nmol/l
0.01
249
1812
318
2415
1.59
8.06
3.8
3.0
0.00
0.00
estimate
-0.00
65
505
324
2493
1.57
7.63
6.8
5.5
56.17
56.02
%
0.08
302
2369
121
724
1.82
7.54
1.2
1.2
9.19
10.47
u/ml
0.08
56
289
138
869
1.74
7.21
2.6
2.4
7.92
7.51
e6/l
0.08
123
776
326
2536
1.54
7.16
7.0
5.6
29.65
29.45
%
0.12
306
2411
176
1187
1.65
7.11
3.6
2.8
0.27
0.36
e6/l
0.52
136
869
597
5370
1.87
7.02
15.5
10.3
20.66
22.30
mg/l
0.62
496
4023
146
942
1.70
6.96
3.1
3.2
1310.97
1180.48
ng/l
0.10
116
781
165
1101
1.66
6.93
2.0
2.4
9188.98
4530.74
umol/l
0.49
142
1007
314
2435
1.53
6.92
3.9
3.1
0.00
0.01
estimate
0.50
55
463
108
641
1.81
6.88
1.7
1.6
1126.40
1126.13
nmol/l
0.00
86
489
314
2437
1.53
6.88
7.3
5.9
8.18
8.40
%
0.79
294
2305
312
2427
1.52
6.72
7.0
5.5
2.68
2.80
%
0.54
290
2293
311
2421
1.52
6.65
5.3
4.2
0.00
0.00
estimate
0.50
61
489
302
2337
1.52
6.64
7.0
5.7
0.70
0.67
%
0.52
282
2197
32
117
2.82
6.63
1.7
1.4
387.92
290.05
ug/g
1.57
20
67
295
2273
1.52
6.61
3.0
2.3
—
—
—
0
0
122
768
1.72
6.33
1.2
1.2
35.42
27.76
iu/ml
0.17
33
246
409
3395
1.51
6.30
4.4
3.6
—
—
—
0
0
222
1624
1.54
6.25
3.8
3.2
92.01
128.32
e6/l
0.35
154
1060
187
1319
1.57
6.17
3.4
2.8
353.13
112.47
e6/l
0.37
144
982
207
1501
1.54
6.03
2.9
2.0
—
—
—
0
0
170
1179
1.59
6.02
3.6
2.7
—
—
—
0
0
138
912
1.64
5.94
1.6
1.4
21.41
20.31
nmol/l
0.34
119
783
72
397
1.91
5.77
6.1
4.3
1.62
1.63
mmol/l
0.01
61
310
116
754
1.65
5.30
4.2
3.0
446.00
613.16
ng/l
0.23
77
507
35
151
2.39
5.26
2.0
1.5
0.22
0.24
g/l
0.62
30
141
109
700
1.66
5.22
3.1
2.4
202.99
116.17
ug/g
0.73
91
549
160
1130
1.54
5.15
3.0
2.0
—
—
—
0
0
176
1270
1.52
5.13
3.5
2.4
—
—
—
0
0
581
5297
1.64
5.09
16.4
11.4
139.66
139.59
mmol/l
0.31
571
5139
159
1125
1.54
5.07
2.3
2.0
2.65
2.91
mg/l
0.72
136
957
193
1426
1.49
5.01
2.8
3.3
7.87
8.31
mmol/l
0.62
167
1251
16
46
3.54
4.92
1.3
1.5
—
—
—
0
0
170
1229
1.51
4.89
4.7
3.7
7.40
7.40
ph
0.18
23
239
65
367
1.85
4.86
2.0
2.1
—
—
—
0
0
293
2356
1.43
4.84
8.9
8.2
0.00
0.00
e9/l
0.63
247
1921
35
157
2.30
4.84
2.0
1.5
1.19
1.19
g/l
0.00
30
147
581
5314
1.61
4.83
16.6
11.5
3.95
3.94
mmol/l
0.64
570
5140
127
870
1.56
4.65
2.9
2.6
548.75
556.10
mosm/kgh2o
0.11
108
744
68
396
1.80
4.61
2.0
2.1
—
—
—
0
0
222
1711
1.44
4.57
3.2
3.3
32.49
31.72
u/l
0.11
216
1636
25
99
2.58
4.51
1.2
1.4
3.81
3.72
mmol/l
0.13
25
93
464
4077
1.43
4.48
4.2
3.7
14.52
14.52
pmol/l
0.01
426
3756
68
400
1.78
4.47
8.2
8.0
5.28
5.13
kpa
0.58
63
387
68
400
1.78
4.47
8.2
7.9
12.59
12.98
kpa
0.24
63
387
68
400
1.78
4.47
1.7
2.1
—
—
—
0
0
102
671
1.61
4.43
1.4
1.4
364.62
454.31
titre
0.36
26
137
68
402
1.77
4.39
2.0
2.1
—
—
—
0
0
35
164
2.20
4.39
1.3
1.2
—
—
—
0
0
172
1272
1.47
4.38
4.2
3.2
0.04
0.01
estimate
0.31
57
484
67
397
1.76
4.30
2.1
2.0
—
—
—
0
0
23
90
2.61
4.26
1.7
1.2
—
—
—
0
0
36
174
2.13
4.19
1.6
2.6
—
—
—
0
0
142
1021
1.49
4.14
1.9
1.8
0.75
1.05
mg/l
1.37
99
756
52
289
1.86
4.11
2.1
2.8
—
—
—
0
0
99
662
1.58
4.02
2.5
2.3
13.02
13.93
umol/l
0.55
86
618
99
663
1.58
3.99
3.4
2.6
4.23
3.72
e6/l
0.18
53
344
536
4890
1.44
3.79
5.0
4.3
6.16
2.09
mu/l
0.45
501
4544
29
134
2.22
3.78
1.6
2.0
0.54
3.42
ug/l
0.78
21
121
53
305
1.80
3.77
2.1
2.2
—
—
—
0
0
66
405
1.70
3.76
8.3
8.0
0.70
0.99
mmol/l
0.20
52
333
69
430
1.67
3.72
2.6
2.1
31.15
41.71
u/l
0.48
60
368
61
368
1.72
3.70
10.9
8.7
—
—
—
0
0
166
1257
1.42
3.67
7.0
6.5
—
—
—
0
0
51
293
1.80
3.65
1.5
1.4
—
—
—
0
0
173
1322
1.41
3.63
1.5
1.4
2.71
1.67
u/ml
0.27
49
338
25
113
2.26
3.45
1.3
1.4
555.36
471.40
mg/l
0.25
25
108
36
190
1.94
3.35
1.1
1.1
—
—
—
0
0
187
1466
1.38
3.35
2.8
3.2
2.37
2.36
mmol/l
0.33
163
1328
62
387
1.66
3.33
2.7
4.2
—
—
—
0
0
52
311
1.73
3.27
2.5
2.2
32.80
25.37
au/ml
—
5
22
38
207
1.88
3.24
4.0
4.5
—
—
—
0
0
118
858
1.45
3.23
1.6
1.6
420.21
25710837.51
pmol/l
1.02
103
739
10
24
4.21
3.20
1.1
3.5
23.67
25.42
umol/l
—
10
24
7
11
6.42
3.19
3.7
11.3
—
—
—
0
0
21
93
2.30
3.06
1.4
1.5
—
—
—
0
0
71
472
1.56
2.98
1.3
1.2
—
—
—
0
0
29
149
1.99
2.94
7.8
5.5
—
—
—
0
0
99
710
1.46
2.91
3.0
2.7
2.43
2.43
mmol/l
0.02
81
632
47
284
1.70
2.87
1.3
1.2
—
32.84
—
0
15
35
194
1.85
2.85
3.4
3.3
—
—
—
0
0
608
5761
1.49
2.80
13.5
9.8
—
—
—
0
0
19
85
2.27
2.72
2.4
2.0
—
—
—
0
0
6
10
6.04
2.70
3.2
1.2
397.67
71.90
nmol/24h
—
6
10
86
614
1.46
2.59
2.5
2.2
2.47
2.38
g/l
0.72
77
569
414
3723
1.28
2.59
3.3
2.9
44.45
41.66
u/l
0.33
396
3539
370
3284
1.28
2.56
3.6
3.0
—
—
—
0
0
650
6270
1.72
2.55
22.4
15.4
264.16
254.55
e9/l
3.34
639
6093
149
1173
1.35
2.55
4.0
3.1
—
—
—
0
0
79
558
1.47
2.52
2.7
2.3
23.85
23.65
%
0.03
65
493
78
551
1.47
2.49
1.8
1.5
—
—
—
0
0
7
16
4.41
2.48
3.4
2.3
14.79
18.53
umol/l
—
7
16
650
6275
1.70
2.47
22.3
15.3
89.97
89.90
fl
0.15
645
6188
85
612
1.44
2.46
2.0
1.9
—
—
—
0
0
530
4937
1.32
2.45
4.2
3.6
5.86
5.79
mmol/l
0.51
495
4552
650
6277
1.70
2.44
22.4
15.3
4.57
4.58
e12/l
0.16
637
6091
650
6277
1.70
2.44
22.3
15.3
30.04
30.07
pg
0.16
645
6188
650
6280
1.69
2.39
22.4
15.4
7.04
6.65
e9/l
4.05
637
6087
650
6281
1.68
2.38
22.5
15.4
136.62
136.91
g/l
0.21
644
6191
33
192
1.76
2.34
8.4
10.5
—
—
—
0
0
62
425
1.50
2.30
4.7
2.9
1.68
1.68
%
0.00
55
383
144
1145
1.33
2.29
3.0
3.4
1515.71
236.73
mg/l
0.88
91
789
71
501
1.47
2.29
1.5
1.3
—
—
—
0
0
43
271
1.63
2.29
2.4
2.2
7.29
8.80
ug/l
0.24
36
245
11
40
2.78
2.28
1.2
1.1
280.00
232.34
mg/l
0.21
11
35
76
547
1.44
2.22
1.4
1.2
—
—
—
0
0
11
41
2.71
2.21
1.4
1.1
41.82
43.16
mg/l
0.03
11
30
602
5744
1.40
2.16
11.1
8.3
28.10
26.92
u/l
0.74
592
5561
280
2439
1.25
2.15
3.3
2.7
99.51
94.68
ug/l
0.21
259
2280
44
284
1.59
2.14
3.4
2.3
—
—
—
0
0
43
279
1.58
2.06
1.4
1.2
—
—
—
0
0
146
1186
1.29
1.99
1.5
1.4
2.04
2.18
g/l
0.46
88
734
28
164
1.74
1.97
1.1
1.1
3.47
8.89
u/ml
—
8
25
29
469
0.60
1.96
1.2
1.3
—
—
—
0
0
44
291
1.55
1.95
5.3
3.0
68.76
68.87
e9/l
0.01
30
210
5
11
4.57
1.94
1.4
1.0
10.92
5.21
mg/g
—
5
11
5
11
4.57
1.94
3.0
2.5
—
—
—
0
0
9
33
2.75
1.93
2.0
1.7
—
—
—
0
0
24
136
1.79
1.89
7.1
4.4
—
—
—
0
0
646
6267
1.54
1.88
22.7
15.4
40.45
40.64
%
0.35
621
5944
88
670
1.36
1.88
3.0
2.2
29.72
29.73
s
0.00
88
654
9
34
2.67
1.87
3.3
3.4
669.78
626.18
u/ml
—
9
34
17
86
2.00
1.86
1.4
2.4
138.33
130.48
g/l
—
9
71
149
1224
1.28
1.86
3.5
4.0
6.77
9.58
mg/mmol
0.49
92
820
6
17
3.55
1.84
1.2
1.2
—
—
—
0
0
6
17
3.55
1.84
1.2
1.4
141.17
137.94
nmol/l
—
6
17
59
421
1.44
1.83
2.0
2.5
0.24
0.22
g/l
0.93
54
398
11
48
2.31
1.71
1.7
1.6
—
—
—
0
0
11
49
2.27
1.64
1.9
2.2
—
—
—
0
0
5
14
3.59
1.62
1.0
1.1
—
547.17
—
0
6
5
14
3.59
1.62
2.8
1.9
—
—
—
0
0
17
91
1.89
1.61
1.3
1.2
4.00
4.24
u/ml
—
7
42
48
339
1.45
1.60
1.4
1.5
19.52
23.77
iu/l
0.54
43
284
29
186
1.58
1.51
1.7
1.6
—
—
—
0
0
13
65
2.02
1.49
1.4
1.6
—
—
—
0
0
481
4528
1.21
1.48
5.3
4.6
39.07
38.79
mmol/mol
0.27
456
4245
49
354
1.41
1.46
1.4
1.3
214.14
179.32
u/ml
0.22
44
324
28
180
1.58
1.45
2.3
2.3
—
—
—
0
0
76
591
1.32
1.44
1.2
1.2
—
—
—
0
0
100
810
1.27
1.41
1.6
1.6
—
—
—
0
0
19
111
1.73
1.40
4.8
3.9
—
—
—
0
0
15
82
1.85
1.36
1.6
1.6
10439.00
16391.68
e6/l
—
9
59
5
17
2.95
1.36
2.0
1.2
—
—
—
0
0
48
351
1.40
1.35
3.1
4.4
0.20
0.15
%
0.13
15
102
68
527
1.32
1.33
3.1
3.2
4.75
6.92
umol/l
1.81
59
458
23
144
1.62
1.33
1.4
1.1
—
—
—
0
0
47
344
1.39
1.32
3.2
4.2
0.53
0.73
%
0.26
15
104
45
327
1.40
1.32
2.9
2.8
3.78
4.81
e9/l
0.94
37
293
79
627
1.29
1.31
1.6
1.8
—
—
—
0
0
8
34
2.37
1.29
3.3
2.8
38375.00
44458.82
ug/l
—
8
34
10
48
2.10
1.28
2.9
2.4
—
—
—
0
0
50
373
1.37
1.26
3.0
4.2
0.71
1.06
%
0.74
17
124
68
532
1.31
1.26
1.4
1.4
—
—
—
0
0
48
356
1.37
1.26
3.3
5.2
2.44
18.74
ug/l
0.73
36
284
5
19
2.64
1.22
1.0
1.0
137.00
164.89
mmol/24h
—
5
19
198
2219
0.85
1.16
2.4
2.4
—
—
—
0
0
27
185
1.48
1.10
1.9
1.7
—
—
—
0
0
7
32
2.20
1.08
1.1
1.2
—
—
—
0
0
53
411
1.31
1.07
1.2
1.3
51.50
158.53
iu/ml
5.25
26
174
9
49
1.85
0.99
1.1
1.3
—
—
—
0
0
11
61
1.82
0.99
1.3
1.3
—
—
—
0
0
44
337
1.33
0.98
3.2
4.4
0.00
0.17
%
1.10
12
87
7
36
1.95
0.97
2.1
1.3
—
—
—
0
0
9
50
1.81
0.97
1.1
1.3
2.67
2.55
g/l
—
9
35
9
50
1.81
0.97
1.1
1.3
0.43
0.36
g/l
—
9
35
9
50
1.81
0.97
1.1
1.3
6.08
6.55
g/l
—
9
35
7
37
1.90
0.94
4.9
2.3
—
—
—
0
0
161
1430
1.16
0.92
3.2
2.7
—
—
—
0
0
6
28
2.15
0.91
1.8
2.5
0.13
0.13
e9/l
—
6
28
14
86
1.64
0.91
1.4
1.7
—
—
—
0
0
6
29
2.08
0.89
1.0
1.0
—
—
—
0
0
26
186
1.41
0.88
1.8
4.4
0.26
0.30
g/l
—
8
95
8
43
1.87
0.87
1.4
1.1
—
—
—
0
0
534
5158
1.16
0.87
4.1
3.7
4.68
4.69
mmol/l
0.07
506
4866
531
5127
1.16
0.87
4.0
3.6
1.39
1.45
mmol/l
3.51
501
4812
6
30
2.01
0.87
1.2
1.1
1647.50
1470.03
miu/ml
—
6
30
64
774
0.81
0.86
1.2
1.3
—
—
—
0
0
28
205
1.38
0.84
3.4
2.5
24.48
21.16
s
0.71
23
182
8
46
1.75
0.82
2.1
1.5
—
—
—
0
0
6
32
1.88
0.82
1.2
1.2
—
—
—
0
0
13
81
1.62
0.81
8.2
2.9
—
—
—
0
0
16
106
1.52
0.79
1.1
1.1
1.26
4.98
u/ml
—
10
57
6
33
1.83
0.79
1.3
1.1
—
—
—
0
0
8
48
1.67
0.79
1.8
2.2
0.87
1.26
e9/l
—
8
42
512
4944
1.14
0.78
3.7
3.3
1.39
1.26
mmol/l
2.70
486
4631
14
90
1.57
0.78
1.1
1.1
0.07
0.57
u/ml
—
7
36
18
123
1.48
0.78
1.4
1.2
—
—
—
0
0
538
5213
1.15
0.78
4.4
4.0
2.82
2.82
mmol/l
0.04
506
4884
169
1529
1.14
0.76
2.0
2.0
—
—
—
0
0
5
24
2.09
0.74
1.4
1.0
165.40
214.76
iu/ml
—
5
24
9
55
1.64
0.73
1.3
1.9
—
—
—
0
0
15
100
1.51
0.73
1.0
1.1
—
—
—
0
0
46
372
1.25
0.72
1.3
1.5
—
—
—
0
0
5
26
1.93
0.70
1.8
1.3
—
—
—
0
0
33
258
1.29
0.68
1.1
1.1
—
—
—
0
0
130
1166
1.14
0.67
3.7
3.8
1.55
2.21
ug/l
1.07
120
1058
7
43
1.63
0.67
1.9
1.1
—
—
—
0
0
210
1941
1.12
0.67
2.2
2.0
—
—
—
0
0
5
28
1.79
0.66
1.0
1.5
—
—
—
0
0
135
1216
1.14
0.65
1.8
1.7
—
—
—
0
0
14
95
1.48
0.64
1.1
1.1
2.81
6.57
u/ml
—
9
45
103
913
1.15
0.63
1.7
1.7
—
—
—
0
0
14
96
1.47
0.62
4.9
3.0
3.88
3.91
e9/l
0.02
14
96
39
317
1.24
0.61
3.6
3.5
4.17
4.75
pmol/l
2.83
34
284
18
131
1.38
0.59
1.9
3.1
—
—
—
0
0
18
131
1.38
0.59
1.2
1.3
—
—
—
0
0
6
36
1.67
0.57
1.2
1.5
—
—
—
0
0
8
55
1.46
0.56
1.4
1.2
—
—
—
0
0
183
1696
1.11
0.55
1.7
1.6
—
—
—
0
0
6
37
1.63
0.55
1.3
1.8
0.27
0.24
e9/l
—
6
31
6
37
1.63
0.55
7.2
3.8
12.83
11.43
%
—
6
37
14
99
1.42
0.54
4.9
3.2
56.86
56.15
%
0.08
14
99
42
350
1.21
0.54
2.1
2.2
6793.59
3914.25
u/l
0.25
14
151
6
39
1.54
0.53
1.3
1.8
328.33
473.87
e6/l
—
6
31
14
100
1.41
0.52
1.9
2.4
238.63
131.14
ug/min
—
8
63
13
94
1.39
0.46
1.4
1.1
—
—
—
0
0
12
86
1.40
0.44
3.8
3.2
42.18
25.01
mg/l
0.31
12
66
12
86
1.40
0.44
3.8
3.2
18.60
111.96
mg/l
0.64
12
65
10
69
1.46
0.44
4.0
3.5
—
—
—
0
0
11
78
1.42
0.43
1.4
1.4
—
—
—
0
0
15
113
1.33
0.43
1.9
2.6
—
—
—
0
0
501
4895
1.09
0.42
18.3
12.9
14.22
14.26
%
0.07
496
4818
30
249
1.21
0.42
5.5
4.9
—
—
—
0
0
24
195
1.24
0.41
1.5
1.2
—
—
—
0
0
5
34
1.47
0.40
1.4
1.5
—
—
nmol/l
—
0
0
5
34
1.47
0.40
1.2
1.2
—
—
—
0
0
5
35
1.43
0.39
3.2
2.2
—
—
—
0
0
48
420
1.15
0.39
2.0
2.1
12.07
12.90
nmol/l
0.30
42
395
5
36
1.39
0.38
1.4
1.7
—
—
—
0
0
5
37
1.35
0.37
1.0
1.0
—
—
—
0
0
9
70
1.29
0.36
1.1
1.0
—
—
—
0
0
31
263
1.19
0.36
1.4
1.3
—
—
—
0
0
34
292
1.17
0.35
1.1
1.2
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
71.50
78.33
umol/l
—
6
43
20
163
1.23
0.34
1.2
1.2
1.77
4.06
u/ml
0.62
12
97
6
45
1.34
0.34
1.0
2.2
—
—
—
0
0
37
322
1.16
0.33
4.1
3.4
1.21
1.23
mmol/l
0.73
32
283
6
47
1.28
0.32
2.8
3.6
—
—
—
0
0
7
54
1.30
0.30
1.6
1.5
147.41
164.48
pmol/l
—
7
54
35
306
1.15
0.30
1.5
1.6
294.45
291.82
mu/l
0.02
29
276
24
203
1.19
0.30
3.2
2.4
—
—
—
0
0
18
148
1.22
0.29
1.2
1.1
0.99
2.75
u/ml
0.98
11
95
12
94
1.28
0.28
1.3
1.1
—
—
—
0
0
18
150
1.21
0.26
1.2
1.1
11.05
6.07
u/ml
—
9
97
6
81
0.74
0.24
7.3
2.8
—
—
—
0
0
14
115
1.22
0.23
1.5
3.3
2.60
9.52
umol/l
—
5
90
17
143
1.19
0.23
1.2
1.1
0.56
2.01
u/ml
—
9
80
48
440
1.10
0.21
3.8
3.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
5
43
1.16
0.21
1.2
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
13.75
—
0
8
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
14
117
1.20
0.20
1.1
1.4
2.88
2.90
ug/l
0.01
14
106
10
80
1.25
0.20
1.4
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
1342.22
—
0
9
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
6
50
1.20
0.19
1.7
2.2
42.03
37.81
%
—
6
50
18
207
0.87
0.19
1.7
1.7
39.11
37.14
nmol/l
0.16
18
200
16
137
1.17
0.19
1.9
1.5
—
—
—
0
0
13
109
1.20
0.18
1.4
1.2
—
—
—
0
0
12
141
0.85
0.16
1.1
1.1
—
—
—
0
0
12
141
0.85
0.16
1.1
1.1
—
—
—
0
0
35
380
0.92
0.16
1.5
1.5
—
—
—
0
0
9
79
1.14
0.15
4.1
3.5
—
—
—
0
0
128
1235
1.04
0.15
1.6
1.6
1.42
1.38
mmol/l
0.21
110
1061
63
597
1.06
0.14
7.9
6.3
1.05
1.08
mmol/l
0.39
57
559
81
843
0.96
0.12
1.5
1.5
—
—
—
0
0
20
218
0.91
0.10
1.6
1.4
—
—
—
0
0
5
45
1.11
0.10
1.4
1.3
—
—
—
0
0
19
174
1.09
0.09
1.2
1.1
—
—
—
0
0
16
145
1.11
0.09
1.6
1.3
348.36
249.89
u/ml
0.65
11
86
55
527
1.05
0.09
1.2
1.4
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
8
90
0.89
0.07
2.0
2.6
—
—
—
0
0
8
93
0.86
0.06
1.0
1.1
—
—
—
0
0
14
151
0.93
0.05
1.4
1.9
2.42
5.96
iu/l
—
6
52
69
704
0.98
0.04
2.4
2.4
0.50
0.75
ug/l
2.66
38
395
53
518
1.03
0.03
1.4
1.6
—
—
—
0
0
21
217
0.97
0.01
1.6
1.4
—
—
—
0
0
10
104
0.96
0.00
5.0
3.0
7.43
7.41
ph
—
10
90
22
223
0.99
0.00
1.6
1.5
—
—
—
0
0
10
99
1.01
0.00
1.0
1.0
—
—
—
0
0
10
101
0.99
0.00
1.4
1.6
—
—
—
0
0
26
261
1.00
0.00
1.2
1.3
272.11
268.21
miu/ml
0.02
16
127
7
73
0.96
-0.00
2.3
2.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
9
93
0.97
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
7.6
—
0.39
—
0
8
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.1
1.27
1.43
g/l
—
8
72
5
49
1.02
-0.00
1.8
2.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.7
277.40
287.41
mosm/kgh2o
—
5
39
8
86
0.93
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
31.00
—
0
5
0
7
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
12
120
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.87
—
0
5

Mortality – FinRegistry

Association

Association between endpoint M13_TORTICOLLIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_TORTICOLLIS 1.139 [0.93, 1.4] 0.219
Birth year 0.997 [0.99, 1.01] 0.44

During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 2594 females with M13_TORTICOLLIS died.

Males

Parameter HR [95% CI] p-value
M13_TORTICOLLIS 1.233 [1.0, 1.51] 0.045
Birth year 0.983 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 3021 males with M13_TORTICOLLIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_TORTICOLLIS.

N-year risk Females Males
1 0.114% 0.207%
5 0.744% 1.233%
10 1.772% 3.16%
15 3.443% 5.849%
20 6.289% 9.76%

Relationships between endpoints

Index endpoint: M13_TORTICOLLIS – Torticollis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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