Ovarian hyperstimulation (induction)

N14_OVAR_HYPERSTIM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N98.1
  • Cause of death: ICD-10 N98.1

2 out of 7 registries used, show all original rules.

660

4. Check minimum number of events

None

660

5. Include endpoints

None

660

6. Filter based on genotype QC (FinnGen only)

660

Control definitions (FinnGen only)

Control exclude
N14_FEMALEINFERT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3890 3890 -
Only index persons 3869 3869 -
Unadjusted period prevalence (%)
Whole population 0.11 0.11 -
Only index persons 0.14 0.14 -
Median age at first event (years)
Whole population - 31.54 -
Only index persons - 31.54 -

-FinnGen-

Key figures

All Female Male
Number of individuals 660 660 -
Unadjusted period prevalence (%) 0.22 0.22 -
Median age at first event (years) 31.68 31.68 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
587
Matched controls
5869
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N98.1
ICD-10 Finland
Hyperstimulation of ovaries
+∞
323.0
586
*
N97.9
ICD-10 Finland
Female infertility, unspecified
465.3
323.0
361
20
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
1025.4
323.0
305
6
G03GA01
ATC
chorionic gonadotrophin; parenteral
136.6
323.0
400
90
G03GA06
ATC
follitropin beta; parenteral
126.1
284.7
293
46
G03GA05
ATC
follitropin alfa; parenteral
129.5
272.8
280
41
H01CA02
ATC
nafarelin; nasal
147.9
269.1
272
34
H01CC01
ATC
ganirelix; parenteral
83.1
245.1
269
59
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
120.0
240.4
250
36
TLW12
NOMESCO Finland
Insertion of frozen embryo
+∞
239.4
213
*
N97.4
ICD-10 Finland
Female infertility associated with male factors
1331.2
200.3
184
*
TLW10
NOMESCO Finland
Transfer of fresh embryo
2342.1
179.8
165
*
N97.0
ICD-10 Finland
Female infertility associated with anovulation
1149.5
179.1
166
*
G03GA02
ATC
human menopausal gonadotrophin; parenteral
65.7
173.1
198
45
N97.8
ICD-10 Finland
Female infertility of other origin
895.5
146.7
138
*
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
599.5
146.2
139
*
TLW00
NOMESCO Finland
Insemination
+∞
141.5
130
*
G03DA04
ATC
progesterone; systemic, rectal, vaginal
44.9
140.1
173
54
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
8.1
114.2
346
882
L02AE01
ATC
buserelin; implant, nasal, parenteral
84.2
99.6
110
16
Z31.2
ICD-10 Finland
In vitrofertilization
1072.2
95.7
91
*
N97.1
ICD-10 Finland
Female infertility of tubal origin
1058.2
94.6
90
*
LAA06
NOMESCO Finland
Transvaginal puncture of ovarian cyst
204.6
70.8
72
*
TLW14
NOMESCO Finland
ICSI
+∞
70.2
66
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
4.7
64.8
420
2056
LA2HE
NOMESCO Finland
Repeated measurement of ovarian cyst
+∞
61.5
58
*
L02BG04
ATC
letrozole; oral
14.0
61.3
109
94
L02AE02
ATC
leuprorelin; implant, parenteral
21.2
59.3
89
49
LA2JE
NOMESCO Finland
Follow-up of menstrual cycle with repeated measurement of ovarian cyst
+∞
57.2
54
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
47.1
55.2
67
16
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.9
54.6
221
649
G03DB01
ATC
dydrogesterone; oral
4.7
54.5
233
723
G03GB02
ATC
clomifene; oral
19.9
52.4
80
46
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
+∞
51.8
49
*
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
7.2
45.9
120
202
B01AB05
ATC
enoxaparin; parenteral
3.6
38.0
217
818
Z31.3
ICD-10 Finland
Other assisted fertilization methods
138.9
37.2
39
*
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
7.1
36.0
93
151
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
11.2
32.2
62
61
H01CC02
ATC
cetrorelix; parenteral
92.9
32.1
35
*
G03GA04
ATC
urofollitropin; parenteral
50.6
31.9
38
8
Z31.1
ICD-10 Finland
Artificial insemination
+∞
30.5
29
*
N80.1
ICD-10 Finland
Endometriosis of ovary
6.4
29.5
82
146
JAH01
NOMESCO Finland
Laparoscopy
5.8
28.9
87
172
Z32.1
ICD-10 Finland
Pregnancy confirmed
3.0
28.2
211
929
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.8
26.5
217
1005
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
25.8
268
1425
O00.1
ICD-10 Finland
Tubal pregnancy
7.3
25.5
63
95
N80.9
ICD-10 Finland
Endometriosis, unspecified
6.6
24.7
66
111
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.9
22.4
164
694
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
4.5
22.4
85
215
L02AE03
ATC
goserelin; implant
15.3
21.9
36
25
G03DC02
ATC
norethisterone; oral
3.8
20.0
91
271
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
38.0
17.7
22
6
LBF00
NOMESCO Finland
Perfusion of Fallopian tube
185.3
17.6
18
*
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.5
17.5
170
832
A10BA02
ATC
metformin; oral
3.2
17.1
99
352
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
5.0
16.8
55
119
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
16.6
284
1802
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
2.3
16.4
185
972
XLA10
NOMESCO Finland
NA
4.2
16.1
64
168
W15
ICPC
Infertility/subfertility female
19.2
16.1
24
13
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
7.5
15.8
37
52
G03GA30
ATC
gonadotropins - combinations; systemic
87.4
15.6
17
*
O00.9
ICD-10 Finland
Ectopic pregnancy, unspecified
7.4
15.6
37
53
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
3.6
15.4
73
224
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.2
14.0
164
867
ULC02
NOMESCO Finland
Hysteroscopy
3.7
13.6
61
179
N97
ICD-10 Finland
Female infertility
21.8
13.4
19
9
O30.0
ICD-10 Finland
Twin pregnancy
4.6
13.4
47
110
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
5.9
13.1
36
64
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
3.9
12.8
54
150
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
9.6
12.6
25
27
SPAT1379
SPAT
Health check-up of pregnant person
2.0
12.5
199
1187
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
11.4
11.6
21
19
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
10.8
11.3
21
20
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
2.3
11.0
113
555
Z31.6
ICD-10 Finland
General counselling and advice on procreation
7.8
10.8
24
32
6289A
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]
+∞
10.4
10
*
J02AC01
ATC
fluconazole; systemic
1.8
10.4
343
2590
N80.0
ICD-10 Finland
Endometriosis of uterus
4.2
9.8
36
89
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.0
9.7
147
849
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.9
9.5
38
102
O02.1
ICD-10 Finland
Missed abortion
2.3
9.4
90
425
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
2.5
9.4
72
305
N84.0
ICD-10 Finland
Polyp of corpus uteri
3.1
9.3
50
170
LAC21
NOMESCO Finland
Laparoscopic destruction of lesion of ovary
5.8
8.8
24
43
O20.0
ICD-10 Finland
Threatened abortion
2.9
8.8
54
198
W78
ICPC
Pregnancy
1.7
8.7
234
1630
355
Kela drug reimbursment
Dienogest
14.7
8.2
13
9
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
0.3
7.9
24
640
N80.89
ICD-10 Finland
Endometriosis with other specified or multiple localization
9.6
7.8
15
16
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
4.7
7.8
25
55
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
7.5
47
177
1413
FHL
Laparoscopy and other therapeutic procedure
6.1
7.4
19
32
N98.8
ICD-10 Finland
Other complications associated with artificial fertilization
+∞
7.3
7
*
N97.2
ICD-10 Finland
Female infertility of uterine origin
+∞
7.3
7
*
N98.9
ICD-10 Finland
Complication associated with artificial fertilization, unspecified
+∞
7.3
7
*
W12
ICPC
Contraception intrauterine
0.5
7.2
52
1002
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.2
259
1927
N83.8
ICD-10 Finland
Other noninflammatory disorders of ovary, fallopian tube and broad ligament
30.4
7.2
9
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
7.0
65
301
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.7
7.0
48
189
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
3.2
7.0
35
114
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
2.0
7.0
92
500
N80
ICD-10 Finland
Endometriosis
5.1
6.9
20
40
TJA10
NOMESCO Finland
Laparocentesis
40.5
6.8
8
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.7
6.7
44
171
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
6.7
103
591
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
2.0
6.7
92
505
O72.0
ICD-10 Finland
Third-stage haemorrhage
3.0
6.7
38
134
1410
FHL
Laparoscopy
5.3
6.7
19
37
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
3.6
6.6
28
81
N80.5
ICD-10 Finland
Endometriosis of intestine
6.3
6.5
16
26
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
2.9
6.4
38
139
O60
ICD-10 Finland
Preterm labour and delivery
2.6
6.4
46
189
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.3
6.4
56
253
SPAT1197
SPAT
Extensive health check-up of expecting family
1.6
6.4
209
1503
N02BE01
ATC
paracetamol; systemic, rectal
1.7
6.4
481
4256
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
3.9
6.3
24
63
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.6
6.3
235
1746
ULB02
NOMESCO Finland
Falloposcopy
+∞
6.3
6
*
B02AA02
ATC
tranexamic acid; systemic
1.8
6.2
120
741
G03DC03
ATC
lynestrenol; oral
3.2
6.2
30
96
G03DB08
ATC
dienogest; oral
12.7
6.1
10
8
N83.1
ICD-10 Finland
Corpus luteum cyst
3.6
6.1
25
71

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
204
503
5.42
81.19
1.6
1.4
—
—
—
0
0
100
177
6.48
55.77
2.2
1.3
2.0
0.3
nmol/l
4.88
95
145
231
910
3.37
45.16
1.7
1.5
—
—
—
0
0
275
1294
2.93
38.36
2.3
1.7
1.0
0.7
mg/l
4.13
226
935
323
1665
2.84
37.80
4.0
4.1
34.6
37.2
g/l
11.98
312
1549
94
224
4.73
37.26
1.2
1.3
9.3
14.2
u/l
2.60
86
179
189
768
3.05
33.77
3.6
2.0
3665.8
5940.2
u/l
0.64
125
292
397
2791
2.06
17.77
3.7
3.0
0.0
0.0
estimate
0.00
96
591
53
143
3.94
17.62
1.4
1.4
—
—
—
0
0
25
34
7.60
17.49
1.0
1.0
—
—
—
0
0
392
2758
2.04
17.33
5.0
4.0
0.0
0.0
estimate
0.50
96
603
307
1999
2.00
16.70
2.3
1.6
—
—
—
0
0
391
2771
2.01
16.66
3.7
2.9
0.0
0.0
estimate
0.00
89
581
110
483
2.53
15.93
1.4
1.6
270.9
294.0
mu/l
0.56
99
429
379
2687
1.96
15.79
4.5
4.0
—
—
—
0
0
480
3705
2.08
15.56
4.4
3.7
3162.8
749.9
e6/l
0.56
12
36
38
89
4.47
15.20
1.5
1.4
1.4
1.9
nmol/l
0.54
31
73
139
709
2.22
14.23
1.3
1.3
12.9
24.5
iu/l
6.31
123
604
492
3888
2.04
14.17
4.6
3.6
—
—
—
0
0
42
120
3.67
12.87
1.4
1.2
—
—
—
0
0
145
786
2.08
12.57
1.5
1.5
—
—
—
0
0
304
2131
1.79
11.91
3.4
2.7
—
—
—
0
0
266
1798
1.80
11.74
1.8
1.6
—
—
—
0
0
229
1485
1.83
11.55
3.9
3.2
0.0
0.0
estimate
0.80
95
600
558
4792
2.06
10.37
4.9
4.3
14.1
14.1
pmol/l
0.35
539
4563
622
5611
2.89
9.89
11.2
9.2
15.9
17.9
mg/l
1.20
534
4263
430
3436
1.72
9.77
3.4
2.9
50.0
54.7
ug/l
1.26
419
3275
589
5195
2.24
9.69
8.8
7.9
138.8
139.4
mmol/l
8.73
584
5043
589
5210
2.21
9.37
8.8
7.9
3.9
3.9
mmol/l
0.47
581
5042
211
1405
1.74
9.36
2.4
2.1
—
—
—
0
0
602
5374
2.37
9.33
5.6
4.9
1.6
1.9
mu/l
0.94
585
5171
48
185
2.72
8.96
1.4
1.5
9.1
23.0
u/l
4.90
41
157
194
1277
1.74
8.90
2.0
2.2
9.5
22.0
ng/l
1.82
50
402
245
1722
1.67
8.79
3.0
2.4
—
—
—
0
0
321
2434
1.62
8.42
2.5
1.9
—
—
—
0
0
177
1179
1.68
7.61
4.1
3.2
1.0
1.0
kg/l
0.34
24
178
228
1649
1.58
6.94
2.0
1.9
—
—
—
0
0
183
1263
1.62
6.74
3.3
4.3
1.0
1.0
inr
0.56
75
480
172
1173
1.63
6.64
3.8
3.0
—
—
—
0
0
30
106
2.92
6.61
2.2
2.7
—
—
—
0
0
229
1677
1.56
6.52
3.1
2.9
83.8
42.8
e6/l
0.42
145
1049
278
2149
1.51
6.06
2.2
1.9
—
—
—
0
0
317
2568
1.45
5.22
3.6
3.7
6.0
6.1
mmol/l
0.29
274
2271
89
545
1.73
5.09
2.9
2.9
—
—
—
0
0
67
377
1.86
5.07
1.1
1.1
—
138.5
—
0
10
217
1644
1.48
5.01
1.2
1.3
0.5
1.7
u/ml
2.84
80
472
636
6034
2.49
4.87
11.7
8.7
—
—
—
0
0
85
525
1.71
4.72
2.5
2.1
24.3
25.0
%
0.17
75
451
105
689
1.62
4.63
1.3
1.2
126.2
152.9
iu/ml
0.30
41
287
130
907
1.54
4.40
2.1
2.2
10.0
9.9
e6/l
0.02
113
785
102
673
1.61
4.39
2.4
2.0
15.0
15.2
umol/l
0.10
94
622
81
511
1.67
4.16
1.2
1.3
—
—
—
0
0
158
1162
1.47
4.14
1.8
1.8
—
—
—
0
0
10
23
4.40
4.10
1.2
1.2
—
—
—
0
0
52
297
1.82
3.79
3.6
3.3
—
—
—
0
0
116
815
1.51
3.78
2.6
3.7
—
—
—
0
0
170
1288
1.43
3.78
2.6
2.5
112.2
115.9
e6/l
0.01
129
953
193
1504
1.40
3.65
3.2
3.8
—
—
—
0
0
89
596
1.57
3.60
2.4
2.0
2.6
2.5
g/l
1.36
83
552
22
92
2.44
3.59
3.7
5.5
—
—
—
0
0
439
3916
1.36
3.41
4.1
3.4
8.4
8.4
mm/h
0.00
421
3716
23
101
2.32
3.39
1.5
1.3
—
—
—
0
0
410
3621
1.35
3.39
5.8
6.0
64.6
69.6
u/l
3.44
393
3419
6
7
8.64
3.27
1.0
1.0
2.9
1.4
nmol/l
—
6
7
151
1154
1.40
3.15
2.4
2.4
0.2
0.2
e6/l
0.35
113
849
169
1317
1.38
3.14
2.3
2.0
2.8
2.6
mg/l
0.46
153
1138
61
386
1.64
3.13
1.4
1.2
—
—
—
0
0
78
524
1.55
3.13
1.5
1.4
—
—
—
0
0
652
6371
2.93
3.11
17.6
13.8
270.5
270.5
e9/l
0.00
647
6272
78
527
1.54
3.05
1.5
1.4
—
—
—
0
0
43
250
1.77
3.00
2.6
2.1
5.1
4.8
umol/l
0.16
33
183
8
224
0.35
2.97
1.6
1.7
—
—
—
0
0
37
207
1.83
2.93
2.8
7.9
4.9
6.6
mmol/l
2.10
37
200
178
1413
1.36
2.93
2.2
2.4
71.6
54.5
u/l
0.46
173
1324
266
2240
1.31
2.92
3.9
4.8
9.5
9.1
umol/l
0.27
251
2099
79
542
1.52
2.89
1.6
1.5
—
—
—
0
0
19
83
2.33
2.86
1.9
2.2
—
—
—
0
0
652
6381
2.80
2.84
17.6
13.9
7.1
6.8
e9/l
3.50
647
6270
652
6380
2.81
2.84
17.6
13.8
4.4
4.5
e12/l
2.16
647
6280
152
1189
1.36
2.73
2.3
2.4
—
—
—
0
0
14
56
2.53
2.54
4.1
3.7
—
—
—
0
0
23
115
2.04
2.53
3.3
2.6
—
—
—
0
0
132
1023
1.36
2.51
2.8
2.1
—
—
—
0
0
38
226
1.72
2.49
1.8
1.7
21.0
20.3
s
0.31
31
181
131
1016
1.36
2.48
2.1
1.9
277.7
2242.4
umol/l
1.84
125
930
19
89
2.17
2.47
1.2
1.1
31.7
72.8
iu/ml
—
6
31
111
839
1.39
2.46
2.5
2.3
498.1
535.7
mosm/kgh2o
0.93
96
712
38
227
1.72
2.45
1.3
1.6
—
—
—
0
0
120
920
1.37
2.44
2.7
2.4
88.7
85.4
ug/g
0.08
104
709
110
838
1.38
2.33
1.6
1.6
418.1
29335499.4
pmol/l
1.07
102
767
14
59
2.40
2.30
1.4
1.2
—
—
—
0
0
120
934
1.35
2.22
1.4
1.4
467.3
568.3
titre
0.33
22
197
538
5069
1.33
2.16
12.7
10.9
13.3
13.4
%
1.37
529
4975
92
689
1.39
2.16
1.3
1.2
—
—
—
0
0
27
152
1.81
2.15
6.0
9.3
23.2
23.9
mmol/l
0.59
27
140
17
82
2.10
2.08
1.4
1.9
1.1
1.9
ug/l
0.24
17
73
5
10
5.03
2.07
1.0
1.1
—
—
—
0
0
15
69
2.20
2.06
1.2
1.1
1.1
1.0
ratio
—
6
25
148
1200
1.30
2.06
1.4
1.5
—
—
—
0
0
8
26
3.10
2.02
1.0
1.5
—
—
—
0
0
339
3040
1.24
1.98
6.4
8.2
4.0
4.0
e9/l
0.04
306
2696
139
1130
1.29
1.89
1.3
1.3
5.7
11.5
u/ml
1.08
61
495
76
566
1.39
1.86
1.8
2.0
384.2
379.7
nmol/l
0.07
68
528
219
1891
1.24
1.78
3.7
4.9
1.2
1.2
mmol/l
0.09
179
1593
165
1381
1.26
1.77
1.3
1.4
1.9
2.1
g/l
1.85
121
924
54
384
1.44
1.72
1.1
1.1
—
—
—
0
0
23
133
1.76
1.72
1.3
1.3
—
—
—
0
0
14
69
2.05
1.65
1.4
1.2
—
—
—
0
0
185
1583
1.23
1.62
1.8
1.7
96.7
99.6
pmol/l
0.40
109
928
520
4935
1.25
1.59
2.9
3.0
5.3
5.5
mmol/l
3.34
495
4679
78
600
1.34
1.58
1.9
1.5
—
—
—
0
0
8
33
2.44
1.54
7.6
10.5
6.4
6.5
mmol/l
—
8
26
267
2385
1.20
1.51
7.6
7.3
0.0
0.0
e9/l
0.14
235
1967
14
72
1.96
1.49
2.4
2.5
—
—
—
0
0
191
1654
1.22
1.49
3.3
4.3
1.2
1.2
mmol/l
0.06
180
1531
7
28
2.52
1.45
1.4
2.5
—
—
—
0
0
22
350
0.62
1.44
1.2
2.2
—
—
—
0
0
26
165
1.60
1.42
1.1
1.1
—
—
—
0
0
26
165
1.60
1.42
1.1
1.1
—
—
—
0
0
268
2405
1.19
1.42
1.9
1.9
—
—
—
0
0
22
134
1.66
1.40
1.3
1.3
7.4
5.3
u/ml
—
9
50
29
190
1.55
1.39
1.0
1.1
1.1
0.8
u/ml
0.11
12
75
20
119
1.70
1.39
1.5
3.3
1.4
1.5
%
0.13
20
119
31
207
1.52
1.38
1.0
1.1
1.7
5.0
u/ml
2.07
18
107
134
1128
1.24
1.37
3.1
3.0
98.8
99.3
%
0.08
129
1085
33
224
1.50
1.36
1.1
1.1
2.6
1.8
u/ml
0.17
14
78
17
97
1.77
1.36
3.8
3.2
33.2
19.9
mg/l
0.65
11
64
34
233
1.48
1.34
4.1
3.6
3.1
28.0
ug/l
0.56
24
158
26
390
0.65
1.33
1.2
1.7
—
—
—
0
0
6
24
2.51
1.30
1.7
2.2
—
105.4
—
0
5
165
1426
1.21
1.30
2.3
2.9
2.3
2.3
mmol/l
0.20
153
1300
29
194
1.52
1.29
1.0
1.1
4.6
1.2
u/ml
—
6
45
8
35
2.30
1.27
1.1
1.7
—
—
—
0
0
16
92
1.76
1.26
1.3
1.4
—
—
—
0
0
22
140
1.59
1.21
4.8
8.2
—
—
—
0
0
27
181
1.51
1.20
1.2
1.2
—
—
—
0
0
6
26
2.32
1.19
2.0
1.8
—
—
—
0
0
20
125
1.62
1.19
5.0
7.4
95.6
94.2
%
1.09
20
125
21
133
1.60
1.18
1.2
2.3
7.4
8.9
mg/l
0.71
21
126
13
223
0.57
1.17
1.3
2.0
—
—
—
0
0
22
142
1.57
1.15
1.6
2.5
41.2
70.3
ng/l
0.75
16
118
32
445
0.70
1.13
1.2
1.7
—
—
—
0
0
35
479
0.72
1.13
1.2
1.7
—
—
—
0
0
329
3046
1.16
1.12
2.4
2.3
—
—
—
0
0
19
120
1.60
1.09
1.3
1.4
—
—
—
0
0
253
2300
1.16
1.09
1.9
2.0
—
—
—
0
0
8
41
1.96
1.09
1.1
1.2
2132.9
1493.0
miu/ml
—
8
41
7
32
2.20
1.08
1.9
2.1
—
—
—
0
0
24
161
1.51
1.08
2.1
3.6
125.5
133.1
g/l
0.92
24
156
24
161
1.51
1.08
7.8
6.9
—
—
—
0
0
83
682
1.25
1.07
2.0
1.7
—
—
—
0
0
37
272
1.38
1.05
3.4
8.7
1.1
1.1
inr
—
7
53
31
221
1.42
1.04
4.6
8.5
97.5
96.7
%
0.94
31
214
9
46
1.97
1.04
1.2
1.6
1.3
1.6
mmol/l
—
9
46
36
482
0.73
1.03
1.2
1.7
—
—
—
0
0
7
34
2.07
1.03
1.0
1.6
—
—
—
0
0
293
2703
1.15
1.02
5.3
5.5
0.0
0.0
e9/l
0.29
269
2416
21
139
1.53
1.01
1.1
1.1
—
—
—
0
0
36
480
0.74
1.01
1.2
1.7
—
—
—
0
0
292
2696
1.15
1.00
5.2
5.4
0.5
0.5
e9/l
1.06
270
2420
24
164
1.48
1.00
1.0
1.1
10.6
3.6
u/ml
—
9
57
73
597
1.25
0.99
1.5
1.8
—
—
—
0
0
11
61
1.82
0.99
1.4
1.3
—
—
—
0
0
5
23
2.18
0.98
2.0
2.6
3.6
3.9
mmol/l
—
5
23
5
23
2.18
0.98
2.0
2.6
107.8
105.9
mmol/l
—
5
23
5
23
2.18
0.98
2.0
2.6
—
—
—
0
0
30
216
1.41
0.97
4.7
8.6
121.1
122.5
g/l
0.15
30
208
10
54
1.86
0.97
2.3
1.2
—
—
nmol/l
—
0
0
9
50
1.81
0.97
3.3
1.6
14.1
33.1
mu/l
—
9
45
303
2813
1.14
0.95
5.2
5.4
2.0
2.0
e9/l
0.19
284
2583
19
125
1.54
0.95
1.2
1.2
—
—
—
0
0
9
51
1.78
0.95
1.2
1.2
—
—
—
0
0
36
473
0.75
0.93
1.2
1.7
—
—
—
0
0
17
110
1.56
0.91
3.6
8.8
2.1
1.7
%
0.49
17
103
68
559
1.24
0.90
1.8
1.6
1503.3
1109.8
nmol/l
2.17
62
446
10
56
1.80
0.88
1.7
1.6
—
—
—
0
0
10
56
1.80
0.88
2.3
1.1
—
—
—
0
0
10
56
1.80
0.88
1.2
1.2
—
—
—
0
0
43
336
1.30
0.85
2.2
3.1
—
—
—
0
0
56
454
1.26
0.84
2.0
2.2
11.1
21.5
au/ml
—
6
39
6
115
0.52
0.83
7.0
6.5
22.7
23.4
mmol/l
—
6
108
45
563
0.78
0.82
1.2
1.4
—
—
—
0
0
455
4365
1.14
0.80
3.6
3.5
35.6
36.7
mmol/mol
3.21
439
4172
0
26
0.00
0.78
0.0
2.7
—
48.4
—
0
13
17
115
1.49
0.77
1.4
1.4
93.0
112.5
u/ml
—
5
26
6
34
1.77
0.76
1.0
2.4
—
—
—
0
0
132
1174
1.16
0.76
1.3
1.3
19.3
23.1
iu/ml
0.27
38
387
9
53
1.71
0.75
1.2
2.0
4.4
4.7
u/ml
—
9
40
300
2817
1.12
0.74
5.3
5.8
0.2
0.2
e9/l
0.08
281
2578
14
92
1.53
0.72
1.2
1.4
—
48.0
—
0
7
12
76
1.59
0.72
2.4
1.8
3.4
2.0
mmol/l
—
6
50
47
573
0.81
0.71
1.1
1.3
—
—
—
0
0
7
41
1.71
0.70
1.1
1.5
93.3
92.4
%
—
7
41
24
178
1.36
0.69
1.1
1.1
12.2
3.2
u/ml
0.57
11
58
16
110
1.47
0.69
3.8
9.0
0.9
0.9
%
0.01
16
103
18
127
1.43
0.68
1.2
1.1
—
—
—
0
0
16
111
1.45
0.66
4.5
3.5
4.3
4.1
e9/l
0.12
16
111
16
112
1.44
0.64
4.4
3.7
56.7
57.7
%
0.09
16
112
26
335
0.77
0.63
1.7
1.4
—
—
—
0
0
17
122
1.40
0.60
4.9
11.1
—
—
—
0
0
34
273
1.26
0.59
4.8
7.4
0.0
0.8
mmol/l
0.32
21
186
33
264
1.26
0.59
1.3
1.3
—
—
—
0
0
23
175
1.33
0.59
1.2
1.1
—
—
—
0
0
10
64
1.57
0.59
2.3
1.2
—
—
nmol/l
—
0
0
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
34
274
1.25
0.58
4.7
7.4
4.7
4.9
kpa
0.78
34
257
34
274
1.25
0.58
4.7
7.4
13.1
14.0
kpa
0.49
34
258
5
86
0.58
0.56
1.0
3.8
0.4
1.0
nmol/l
—
5
73
102
1132
0.88
0.53
1.7
1.5
1.6
1.3
mmol/l
0.57
94
1025
9
62
1.46
0.53
4.4
14.1
12.2
11.1
mmol/l
—
9
57
9
62
1.46
0.53
1.1
2.0
—
—
—
0
0
9
63
1.43
0.52
4.4
13.9
105.2
105.4
mmol/l
—
9
58
24
188
1.29
0.52
3.6
2.1
—
—
—
0
0
9
65
1.39
0.50
1.1
1.1
191.6
199.2
mg/l
—
9
52
33
271
1.23
0.49
1.2
1.2
—
—
—
0
0
72
636
1.15
0.49
1.2
1.1
—
—
—
0
0
97
875
1.13
0.48
1.7
1.4
22.4
20.4
nmol/l
0.67
92
798
66
582
1.15
0.46
1.1
1.2
—
—
—
0
0
257
2442
1.09
0.46
5.2
5.4
0.7
0.7
%
0.01
245
2287
10
69
1.46
0.44
1.0
1.1
31.1
32.4
mg/l
—
10
52
97
883
1.12
0.42
2.2
2.2
—
—
—
0
0
10
70
1.44
0.42
1.4
1.9
45.2
189.9
ug/l
—
10
59
0
15
0.00
0.41
0.0
2.3
—
1.2
—
0
15
0
16
0.00
0.41
0.0
1.0
—
5.1
—
0
16
0
16
0.00
0.41
0.0
1.1
—
35.7
—
0
16
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
24
195
1.24
0.41
1.0
1.1
—
—
—
0
0
8
59
1.36
0.41
2.8
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
71
637
1.13
0.40
1.8
2.1
2.4
2.4
mmol/l
0.41
63
547
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
5
35
1.43
0.39
1.2
1.8
—
—
—
0
0
12
89
1.35
0.38
2.4
2.4
7.4
7.4
ph
0.30
12
75
9
69
1.31
0.37
1.3
1.2
—
—
—
0
0
120
1116
1.09
0.36
2.7
3.0
7.4
7.4
ph
0.30
39
219
27
227
1.20
0.35
2.7
3.6
1.9
1.5
mmol/l
0.33
21
173
6
45
1.34
0.34
2.2
1.8
—
—
—
0
0
34
294
1.16
0.33
1.7
1.6
—
—
—
0
0
6
47
1.28
0.32
1.2
1.6
7.2
6.1
ug/l
—
6
40
7
54
1.30
0.30
1.0
1.1
—
—
—
0
0
21
175
1.21
0.30
2.3
2.0
—
—
—
0
0
31
356
0.86
0.30
4.6
4.2
0.0
0.1
%
—
7
67
18
148
1.22
0.29
1.3
1.7
—
—
—
0
0
266
2571
1.06
0.28
5.3
5.5
7.7
7.6
%
0.16
256
2435
23
196
1.18
0.27
1.6
2.2
79.5
75.9
e9/l
0.19
16
138
264
2554
1.06
0.27
5.2
5.3
2.5
2.7
%
0.55
253
2390
56
511
1.10
0.26
1.6
2.4
6.4
5.1
umol/l
0.28
43
415
8
67
1.20
0.26
1.0
1.0
—
—
—
0
0
8
67
1.20
0.26
1.8
2.0
—
—
—
0
0
16
132
1.22
0.26
1.3
1.3
211.1
213.0
u/ml
—
9
90
10
78
1.29
0.24
1.6
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
15
125
1.20
0.22
1.1
1.1
11.8
19.8
au/ml
—
5
14
40
363
1.11
0.21
2.6
2.0
—
—
—
0
0
276
2687
1.05
0.21
5.1
5.3
30.8
29.6
%
1.28
265
2543
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.6
—
0
7
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
59.9
—
0
7
0
14
0.00
0.20
0.0
2.5
—
—
—
0
0
21
239
0.87
0.19
3.8
4.7
1.0
1.3
mmol/l
0.93
21
226
26
291
0.89
0.19
1.0
1.1
—
—
—
0
0
7
61
1.15
0.17
1.3
2.4
25.2
23.5
mmol/l
—
7
53
16
139
1.15
0.16
1.2
1.8
—
—
—
0
0
16
139
1.15
0.16
4.5
3.3
0.6
0.3
g/l
—
7
49
271
2658
1.03
0.14
4.9
5.1
55.8
57.0
%
1.24
262
2516
168
1635
1.04
0.13
5.5
5.5
—
—
—
0
0
48
452
1.07
0.13
1.3
1.3
—
—
—
0
0
39
417
0.93
0.13
1.4
1.3
170.8
242.1
miu/ml
0.72
23
216
36
386
0.93
0.13
4.2
4.1
0.9
1.0
%
—
8
86
563
5594
1.04
0.12
11.2
9.8
39.2
39.6
%
0.63
469
4786
43
409
1.05
0.09
1.4
1.2
—
—
—
0
0
6
56
1.07
0.08
1.0
1.3
—
—
—
0
0
34
358
0.95
0.08
3.2
3.9
1.3
0.8
%
—
6
68
498
4952
1.02
0.07
2.8
2.7
1.2
1.1
mmol/l
0.63
480
4748
526
5242
1.02
0.04
3.1
3.1
2.9
2.9
mmol/l
0.16
503
5014
10
109
0.92
0.04
1.1
1.1
—
—
—
0
0
128
1264
1.02
0.04
4.4
6.2
—
—
—
0
0
101
999
1.01
0.02
1.2
1.3
—
—
—
0
0
63
621
1.02
0.02
1.9
2.3
11.6
435.0
ng/l
1.44
25
248
10
107
0.93
0.02
1.5
1.6
—
—
—
0
0
79
781
1.01
0.01
4.1
4.1
12.7
14.2
mg/mmol
0.11
54
505
13
137
0.95
0.01
1.1
1.3
—
—
—
0
0
20
194
1.03
0.00
4.8
6.5
—
—
—
0
0
36
366
0.98
0.00
4.2
4.2
0.0
0.1
%
—
8
78
59
584
1.01
0.00
1.3
1.3
—
—
—
0
0
10
95
1.05
0.00
1.4
2.9
—
—
—
0
0
10
105
0.95
0.00
1.1
1.0
—
—
—
0
0
14
143
0.98
0.00
1.1
1.2
—
818.9
—
0
9
14
142
0.99
0.00
1.1
1.2
—
82.5
—
0
12
16
158
1.01
0.00
1.9
1.9
13.3
13.1
%
0.13
16
158
17
168
1.01
0.00
1.3
1.3
—
—
—
0
0
521
5214
1.00
0.00
3.1
3.0
4.8
4.8
mmol/l
0.18
502
5022
13
131
0.99
0.00
1.2
1.3
369.5
367.5
ug/g
—
6
59
520
5197
1.00
0.00
3.1
2.9
1.5
1.5
mmol/l
0.57
502
4996
7
72
0.97
0.00
1.0
1.9
128.4
134.4
g/l
—
7
52
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
0
5
0.00
0.00
0.0
6.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
2.0
—
0
8
0
9
0.00
0.00
0.0
8.9
—
—
—
0
0
8
81
0.99
0.00
1.4
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
10.3
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.2
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
7
70
1.00
0.00
2.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
19.6
—
0
5
0
5
0.00
0.00
0.0
9.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
16.5
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
6
65
0.92
0.00
1.7
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
277.4
—
0
5
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
14.7
—
0
6
76
760
1.00
0.00
3.6
3.3
926.2
490.9
mg/l
0.21
51
495
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
451.9
—
0
7
0
6
0.00
0.00
0.0
6.3
—
0.2
—
0
6

Mortality – FinRegistry

Association

Association between endpoint N14_OVAR_HYPERSTIM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_OVAR_HYPERSTIM.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_OVAR_HYPERSTIM – Ovarian hyperstimulation (induction)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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