Risteys · Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Q62 Cause of death: ICD-10 — Q62 2 out of 7 registries used, show all original rules.	757
4. Check minimum number of events None	757
5. Include endpoints None	757
6. Filter based on genotype QC (FinnGen only)	757

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	10797	5507	5270
Only index persons	8505	4638	3867
Unadjusted period prevalence (%)
Whole population	0.15	0.16	0.15
Only index persons	0.16	0.17	0.15
Median age at first event (years)
Whole population	2.92	4.58	1.05
Only index persons	4.71	6.19	2.94

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	757	486	271
Unadjusted period prevalence (%)	0.15	0.17	0.12
Median age at first event (years)	23.50	23.67	23.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
660: Matched controls
6598

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Q62.10

ICD-10 Finland

Congenital unilateral occlusion of the pelvic ureteral junction

+∞

279.7

248

Q62.7

ICD-10 Finland

Congenital vesico-uretero-renal reflux

+∞

233.6

210

N13.3

ICD-10 Finland

Other and unspecified hydronephrosis

111.3

157.1

167

UKC02

NOMESCO Finland

Cystoscopy

13.5

135.4

260

302

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

9.9

107.5

244

368

Q62.0

ICD-10 Finland

Congenital hydronephrosis

+∞

106.2

KBV12

NOMESCO Finland

Transluminal endoscopic removal of stent from ureter

88.5

101.0

111

N13.0

ICD-10 Finland

Hydronephrosis with ureteropelvic junction obstruction

294.0

100.8

100

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

14.0

93.9

170

159

KAH41

NOMESCO Finland

Percutaneous endoscopic pyeloureteroplasty with division of ureteropelvic junction

523.1

93.8

J01EA01

ATC

trimethoprim; systemic

5.5

81.2

315

941

KBV52

NOMESCO Finland

Cystoscopic injection therapy for vesicourethral reflux

842.5

78.0

KBV02

NOMESCO Finland

Cystoscopic insertion of stent into ureter

32.5

75.5

100

Q62.5

ICD-10 Finland

Duplication of ureter

+∞

66.8

KA1FN

NOMESCO Finland

Isotope renography

81.7

65.6

G04AC01

ATC

17.4

59.5

KA1AE

NOMESCO Finland

Kidney ultrasound examination

21.5

53.8

N13.7

ICD-10 Finland

Vesicoureteral-reflux-associated uropathy

195.7

52.8

1530

FHL

Urethrocystoscopy

31.9

52.2

J01XE01

ATC

nitrofurantoin; oral

21.9

46.8

KH1CD

NOMESCO Finland

Very extensive urinary tract ultrasound examination

40.6

44.9

KBH20

NOMESCO Finland

Replantation of ureter

467.9

44.8

KAH40

NOMESCO Finland

Pyeloureteroplasty with division of ureteropelvic junction

+∞

42.1

J01MA02

ATC

ciprofloxacin; systemic

3.3

39.9

277

1200

UKB02

NOMESCO Finland

Retrograde ureteroscopy

68.8

39.6

WX408

NOMESCO Finland

General anesthesy, balanced

3.3

38.5

258

1083

5937A

ICD-9 Finland

Other disorders of kidney and ureter, Vesicoureteric reflux

42.0

38.0

KC1JB

NOMESCO Finland

Miktiocystography with X-ray

388.2

37.4

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

4.1

35.7

160

481

XKD00

NOMESCO Finland

Uroflowmetry

4.9

35.7

128

309

Q62.2

ICD-10 Finland

Congenital megaloureter

+∞

34.7

Q62.18

ICD-10 Finland

Other specified atresia and stenosis of ureter

+∞

33.6

N18.8

ICD-10 Finland

Other chronic renal failure

17.7

32.5

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

18.8

31.9

N13.9

ICD-10 Finland

Obstructive and reflux uropathy, unspecified

+∞

31.5

KH1BD

NOMESCO Finland

Extensive urinary tract CT examination

32.6

30.7

TPH04

NOMESCO Finland

Cathetrisation of vein

3.3

30.0

182

688

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

4.8

29.9

107

255

ZXE20

NOMESCO Finland

More than three and less than five hours

3.8

29.6

139

429

Q62.3

ICD-10 Finland

Other obstructive defects of renal pelvis and ureter

+∞

29.4

204

Kela drug reimbursment

Leukemia lymphatica

9.6

29.4

Z94.0

ICD-10 Finland

Kidney transplant status

23.6

28.2

5910A

ICD-9 Finland

Hydronephrosis[HYDRONEPHROSIS]

293.4

28.0

A11CC03

ATC

alfacalcidol; systemic

14.0

27.4

KH1AD

NOMESCO Finland

CT of urinary organs

9.0

26.1

KH1BT

NOMESCO Finland

Urinary tract cathetrisation with X-ray guidance

42.0

26.0

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

16.7

25.8

KH1EE

NOMESCO Finland

Urologic ultrasound examination

37.3

25.4

ZXD10

NOMESCO Finland

Scheduled procedure

2.5

25.4

287

1562

KA1MN

NOMESCO Finland

Glomerular filtration rate (GFR) Isotope mesurement

14.9

25.2

5901A

ICD-9 Finland

Infections of kidney, Acute pyelonephritis

18.2

24.7

N20.0

ICD-10 Finland

Calculus of kidney

13.1

24.4

KA3GB

NOMESCO Finland

Retrograde pyelography

248.6

23.8

R4110

NOMESCO Finland

Physiotherapy

2.7

23.6

205

958

KBV10

NOMESCO Finland

Removal of stent from ureter

37.8

23.2

Q62.11

ICD-10 Finland

Congenital bilateral occlusion of the pelvic ureteral junction

+∞

23.1

Q64.2

ICD-10 Finland

Congenital posterior urethral valves

+∞

23.1

ZXE10

NOMESCO Finland

More than one and less than three hours

2.4

22.8

254

1354

ZXC96

NOMESCO Finland

Robot assisted procedure

13.7

22.7

127

Kela drug reimbursment

Transplant complication

12.8

22.6

KA2AE

NOMESCO Finland

Ultrasound examination transplanted kidney

28.5

22.4

A12AA04

ATC

calcium carbonate; oral

20.4

22.3

N30.0

ICD-10 Finland

Acute cystitis

3.0

21.8

141

545

KA3EB

NOMESCO Finland

Antegrade pyelography

51.8

21.3

N18.0

ICD-10 Finland

End-stage renal disease

25.2

21.0

XKC03

NOMESCO Finland

Water cystometry

7.9

20.0

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

30.0

19.8

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

8.6

19.8

ZXE00

NOMESCO Finland

One hour or less

2.2

19.7

292

1751

KH1AA

NOMESCO Finland

Urinary tract X-ray examination without contrast

17.4

19.3

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

15.9

18.1

R31

ICD-10 Finland

Unspecified haematuria

4.3

17.8

176

N13.1

ICD-10 Finland

Hydronephrosis with ureteral stricture, not elsewhere classified

68.6

17.8

Q61.2

ICD-10 Finland

Polycystic kidney, autosomal dominant

+∞

17.8

KBV00

NOMESCO Finland

Insertion of stent into ureter

36.1

16.8

Q62.8

ICD-10 Finland

Other congenital malformations of ureter

+∞

16.7

KH1CB

NOMESCO Finland

Urography with X-ray

92.5

16.6

R50.9

ICD-10 Finland

Fever, unspecified

2.5

16.3

142

644

ZXD05

NOMESCO Finland

Urgent procedure

2.2

16.2

211

1171

L04AA06

ATC

mycophenolic acid; systemic

8.9

16.1

Q62.6

ICD-10 Finland

Malposition of ureter

+∞

15.7

TKC20

NOMESCO Finland

Catheterisation of bladder

4.2

15.6

157

U14

ICPC

Kidney symptom/complaint

12.7

15.5

N28.8

ICD-10 Finland

Other specified disorders of kidney and ureter

39.1

15.5

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

29.4

15.3

KA2AT

NOMESCO Finland

Biopsy of transplanted kidney with ultrasound guidance

20.6

15.2

WX402

NOMESCO Finland

General anaesthesia

2.4

14.8

141

671

ZXA00

NOMESCO Finland

Right side

2.3

14.8

153

756

Q62.12

ICD-10 Finland

Congenital occlusion of ureterovesical orifice

+∞

14.6

Z49.1

ICD-10 Finland

Extracorporeal dialysis

14.6

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.5

13.9

124

569

B03XA02

ATC

darbepoetin alfa; parenteral

12.4

13.7

KAH62

NOMESCO Finland

Endopyelotomy

+∞

13.6

J01CA08

ATC

pivmecillinam; oral

1.9

13.4

271

1765

TK800

NOMESCO Finland

Hemodialysis

9.0

13.1

KAT00

NOMESCO Finland

Extracorporeal shock wave lithotripsy of pelvis of kidney

17.1

13.0

Z3226

NOMESCO Finland

Physiotherapist

2.2

12.9

147

757

J01DA01

ATC

[U] cefalexin; systemic

1.8

12.7

382

2829

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

12.6

12.7

7187

FHL

Ureterohydroplasty due to reflux, for example

132.4

12.5

KH1FT

NOMESCO Finland

Exchange of urinary catheter with radiological guidance

132.4

12.5

KBV15

NOMESCO Finland

Cystoscopic change of ureteral stent

38.3

12.2

196

Kela drug reimbursment

Paricalcitol and cinacalcet

38.3

12.2

XF602

NOMESCO Finland

Bloodpressure monitoring

16.3

12.2

KAC00

NOMESCO Finland

Nephrectomy

18.5

12.1

G04BD04

ATC

oxybutynin; oral, transdermal

4.3

12.0

107

7143

FHL

Pyeloureteroplasty

47.6

11.9

TPH07

NOMESCO Finland

Cathetrisation of artery

3.0

11.7

258

V03AE01

ATC

polystyrene sulfonate; oral

16.8

11.7

7532A

ICD-9 Finland

Congenital anomalies of urinary system, Obstructive defects of renal pelvis and ureter

66.2

11.6

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

3.5

11.6

168

Q61.0

ICD-10 Finland

Congenital single renal cyst

+∞

11.5

KAH30

NOMESCO Finland

Pyeloureteroplasty without division of ureteropelvic junction

+∞

11.5

J01MA06

ATC

norfloxacin; oral

2.7

11.5

313

ZXD20

NOMESCO Finland

Day surgery

2.5

11.2

382

N25.8

ICD-10 Finland

Other disorders resulting from impaired renal tubular function

25.5

11.2

Z2221

NOMESCO Finland

Medical doctor

1.9

10.9

193

1175

N13.8

ICD-10 Finland

Other obstructive and reflux uropathy

+∞

10.4

7534X

ICD-9 Finland

Congenital anomalies of urinary system, Other specified anomalies of ureter

+∞

10.4

Q60.3

ICD-10 Finland

Renal hypoplasia, unilateral

+∞

10.4

KDD52

NOMESCO Finland

Urethroscopic excision of urethral valve

+∞

10.4

Z3231

NOMESCO Finland

Registered nurse

1.9

10.4

201

1263

B03XA01

ATC

erythropoietin; parenteral

12.3

10.4

KAE12

NOMESCO Finland

Retrograde ureteronephroscopic lithotripsy in pelvis of kidney

19.1

10.3

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

19.1

10.3

320

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

23.8

10.3

N30.9

ICD-10 Finland

Cystitis, unspecified

3.3

10.1

164

ZXA05

NOMESCO Finland

Left side

2.1

10.1

132

712

137

Kela drug reimbursment

Uraemia requiring dialysis

11.5

10.1

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.0

10.0

149

850

L04AD01

ATC

ciclosporin; systemic

5.8

9.6

N12

ICD-10 Finland

Tubulo-interstitial nephritis, not specified as acute or chronic

7.7

9.5

7219

FHL

Other measure in this category

101.4

9.4

V03AE02

ATC

sevelamer; oral

30.5

9.4

Q60.0

ICD-10 Finland

Renal agenesis, unilateral

+∞

9.4

Q61.3

ICD-10 Finland

Polycystic kidney, unspecified

+∞

9.4

Q61.1

ICD-10 Finland

Polycystic kidney, autosomal recessive

+∞

9.4

KCF02

NOMESCO Finland

Transluminal endoscopic removal of foreign body from bladder

+∞

9.4

N26

ICD-10 Finland

Unspecified contracted kidney

+∞

9.4

N20.1

ICD-10 Finland

Calculus of ureter

4.4

9.2

V03AE03

ATC

lanthanum carbonate; oral

37.2

9.0

KAS20

NOMESCO Finland

Allogenic transplantation of kidney from living donor

24.4

8.9

5990C

ICD-9 Finland

Other disorders of urethra and urinary tract, Urinary tract infection, site not specified[INFECTIO VIARUM URINARIUM RECIDIVANS]

24.4

8.9

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

3.5

8.9

119

5990B

ICD-9 Finland

Other disorders of urethra and urinary tract, Urinary tract infection, site not specified[INFECTIO VIARUM URINARIUM ACUTA]

9.7

8.8

N02AX02

ATC

tramadol; systemic, rectal

1.7

8.7

200

1315

B05DB

ATC

Hypertonic solutions

16.5

8.6

IAZ97

NOMESCO Finland

Psychiatric consultation in another specialty

4.7

8.6

KCW98

NOMESCO Finland

Other transluminal endoscopic operation on bladder

27.9

8.5

KBV42

NOMESCO Finland

Cystoscopic incision or excision of ureterocele

91.2

8.4

WX302

NOMESCO Finland

Thoracal epidural anesthesy

3.6

8.4

103

Q61.40

ICD-10 Finland

Renal dysplasia of a kidney (multicystic)

+∞

8.3

7533X

ICD-9 Finland

Congenital anomalies of urinary system, Other specified anomalies of kidney

+∞

8.3

Q61.99

ICD-10 Finland

Cystic kidney disease, unspecified

+∞

8.3

F98.02

ICD-10 Finland

Non-organic nocturnal and diurnal enuresis

9.6

8.3

J01MA12

ATC

levofloxacin; systemic

2.1

8.2

458

B34.9

ICD-10 Finland

Viral infection, unspecified

3.1

8.1

145

N30

ICD-10 Finland

Cystitis

2.5

8.1

262

H05BX01

ATC

cinacalcet; oral

22.3

8.0

N20.9

ICD-10 Finland

Urinary calculus, unspecified

5.3

7.9

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.7

7.8

225

1569

5AB14

NOMESCO Finland

18.6

7.6

KDV20

NOMESCO Finland

Submucous urethral injection

25.3

7.6

KA9AE

NOMESCO Finland

Ultrasound examination transplanted kidney

81.0

7.4

N28.1

ICD-10 Finland

Cyst of kidney

13.6

7.4

WZC30

NOMESCO Finland

Teaching

2.2

7.3

342

Q62.1

ICD-10 Finland

Atresia and stenosis of ureter

+∞

7.3

7186

FHL

Ureteroplasty, narrowing and resection (includes neoimplantation)

+∞

7.3

KBJ00

NOMESCO Finland

Cutaneous ureterostomy

+∞

7.3

UKA02

NOMESCO Finland

Retrograde ureteronephroscopy

30.4

7.2

Z99.2

ICD-10 Finland

Dependence on renal dialysis

20.3

7.1

B05DA

ATC

Isotonic solutions

10.2

7.1

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.6

7.0

236

1705

R39.1

ICD-10 Finland

Other difficulties with micturition

5.1

6.8

N13.2

ICD-10 Finland

Hydronephrosis with renal and ureteral calculous obstruction

40.5

6.8

3076C

ICD-9 Finland

Special symptoms or syndromes not elsewhere classified, Enuresis[YÖ- JA PÄIVÄKASTELU]

40.5

6.8

R93.4

ICD-10 Finland

Abnormal findings on diagnostic imaging of urinary organs

16.9

6.8

N19

ICD-10 Finland

Unspecified kidney failure

5.3

6.7

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.7

6.6

160

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

2.1

6.5

370

Q42.2

ICD-10 Finland

Congenital absence, atresia and stenosis of anus with fistula

70.5

6.4

R33

ICD-10 Finland

Retention of urine

3.0

6.4

122

Z49.0

ICD-10 Finland

Preparatory care for dialysis

14.5

6.4

C08CA01

ATC

amlodipine; oral

1.7

6.3

131

823

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.4

6.3

215

4AA09

NOMESCO Finland

18.2

6.3

7536A

ICD-9 Finland

Congenital anomalies of urinary system, Atresia and stenosis of urethra and bladder neck[OBSTRUCTIO URETHRAE ET COLLI VESICAE CONGENITA]

+∞

6.3

Q61.48

ICD-10 Finland

Nonspecified renal dysplasia

+∞

6.3

7188

FHL

Ureteroneocystostomy

+∞

6.3

H05BX02

ATC

paricalcitol; systemic

+∞

6.3

KAD10

NOMESCO Finland

Heminephrectomy

+∞

6.3

Q62.4

ICD-10 Finland

Agenesis of ureter

+∞

6.3

R62.8

ICD-10 Finland

Other lack of expected normal physiological development

7.1

6.2

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

3.9

6.2

H01AC01

ATC

somatropin; parenteral

5.1

6.2

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

3.1

6.1

103

5604

FHL

Vascular preparation or cannulation in the operating room

12.7

6.1

WX892

NOMESCO Finland

Monitored bed care

2.4

6.1

201

ZXE30

NOMESCO Finland

More than five and less than seven hours

2.8

6.1

132

J01DB01

ATC

cefalexin; oral

1.6

6.0

504

4433

Z3229

NOMESCO Finland

Other healthcare associate professional

2.2

6.0

294

RD210

NOMESCO Finland

3.0

6.0

110

205

Kela drug reimbursment

Chronic hypertension

1.9

6.0

534

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER and mortality.

Females

Parameter	HR [95% CI]	p-value
Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER	1.465 [1.2, 1.79]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.145

During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 4672 females with Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER died.

Males

Parameter	HR [95% CI]	p-value
Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER	1.668 [1.31, 2.13]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.005

During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 4660 males with Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER.

N-year risk	Females	Males
1	0.093%	0.297%
5	0.765%	1.81%
10	1.936%	4.479%
15	3.673%	8.582%
20	6.517%	15.033%

Relationships between endpoints

↥

Index endpoint: Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER – Congenital obstructive defects of renal pelvis and congenital malformations of ureter

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER
CONTROL_EXCLUDE	Q17_CONGEN_MALFO_URINARY_SYSTEM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Q62
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Q62
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Congenital obstructive defects of renal pelvis and congenital malformations of ureter

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints