Congenital obstructive defects of renal pelvis and congenital malformations of ureter

Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q62
  • Cause of death: ICD-10 Q62

2 out of 7 registries used, show all original rules.

757

4. Check minimum number of events

None

757

5. Include endpoints

None

757

6. Filter based on genotype QC (FinnGen only)

757

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_URINARY_SYSTEM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[0-4]
Name in latin
Defectus obstructivi congeniti pelvis renalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10797 5507 5270
Only index persons 8505 4638 3867
Unadjusted period prevalence (%)
Whole population 0.15 0.16 0.15
Only index persons 0.16 0.17 0.15
Median age at first event (years)
Whole population 2.92 4.58 1.05
Only index persons 4.71 6.19 2.94

-FinnGen-

Key figures

All Female Male
Number of individuals 757 486 271
Unadjusted period prevalence (%) 0.15 0.17 0.12
Median age at first event (years) 23.50 23.67 23.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
660
Matched controls
6598
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q62.10
ICD-10 Finland
Congenital unilateral occlusion of the pelvic ureteral junction
+∞
279.7
248
*
Q62.7
ICD-10 Finland
Congenital vesico-uretero-renal reflux
+∞
233.6
210
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
111.3
157.1
167
20
UKC02
NOMESCO Finland
Cystoscopy
13.5
135.4
260
302
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
9.9
107.5
244
368
Q62.0
ICD-10 Finland
Congenital hydronephrosis
+∞
106.2
99
*
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
88.5
101.0
111
15
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
294.0
100.8
100
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
14.0
93.9
170
159
KAH41
NOMESCO Finland
Percutaneous endoscopic pyeloureteroplasty with division of ureteropelvic junction
523.1
93.8
91
*
J01EA01
ATC
trimethoprim; systemic
5.5
81.2
315
941
KBV52
NOMESCO Finland
Cystoscopic injection therapy for vesicourethral reflux
842.5
78.0
75
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
32.5
75.5
100
36
Q62.5
ICD-10 Finland
Duplication of ureter
+∞
66.8
63
*
KA1FN
NOMESCO Finland
Isotope renography
81.7
65.6
73
10
G04AC01
ATC
NA
17.4
59.5
96
64
KA1AE
NOMESCO Finland
Kidney ultrasound examination
21.5
53.8
80
42
N13.7
ICD-10 Finland
Vesicoureteral-reflux-associated uropathy
195.7
52.8
54
*
1530
FHL
Urethrocystoscopy
31.9
52.2
69
24
J01XE01
ATC
nitrofurantoin; oral
21.9
46.8
69
35
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
40.6
44.9
56
15
KBH20
NOMESCO Finland
Replantation of ureter
467.9
44.8
44
*
KAH40
NOMESCO Finland
Pyeloureteroplasty with division of ureteropelvic junction
+∞
42.1
40
*
J01MA02
ATC
ciprofloxacin; systemic
3.3
39.9
277
1200
UKB02
NOMESCO Finland
Retrograde ureteroscopy
68.8
39.6
45
7
WX408
NOMESCO Finland
General anesthesy, balanced
3.3
38.5
258
1083
5937A
ICD-9 Finland
Other disorders of kidney and ureter, Vesicoureteric reflux
42.0
38.0
47
12
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
388.2
37.4
37
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
4.1
35.7
160
481
XKD00
NOMESCO Finland
Uroflowmetry
4.9
35.7
128
309
Q62.2
ICD-10 Finland
Congenital megaloureter
+∞
34.7
33
*
Q62.18
ICD-10 Finland
Other specified atresia and stenosis of ureter
+∞
33.6
32
*
N18.8
ICD-10 Finland
Other chronic renal failure
17.7
32.5
51
31
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
18.8
31.9
49
28
N13.9
ICD-10 Finland
Obstructive and reflux uropathy, unspecified
+∞
31.5
30
*
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
32.6
30.7
40
13
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
30.0
182
688
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.8
29.9
107
255
Q62.3
ICD-10 Finland
Other obstructive defects of renal pelvis and ureter
+∞
29.4
28
*
204
Kela drug reimbursment
Leukemia lymphatica
9.6
29.4
61
69
Z94.0
ICD-10 Finland
Kidney transplant status
23.6
28.2
40
18
5910A
ICD-9 Finland
Hydronephrosis[HYDRONEPHROSIS]
293.4
28.0
28
*
A11CC03
ATC
alfacalcidol; systemic
14.0
27.4
47
36
KH1AD
NOMESCO Finland
CT of urinary organs
9.0
26.1
56
67
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
42.0
26.0
32
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
16.7
25.8
41
26
KH1EE
NOMESCO Finland
Urologic ultrasound examination
37.3
25.4
32
9
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
14.9
25.2
42
30
5901A
ICD-9 Finland
Infections of kidney, Acute pyelonephritis
18.2
24.7
38
22
N20.0
ICD-10 Finland
Calculus of kidney
13.1
24.4
43
35
KA3GB
NOMESCO Finland
Retrograde pyelography
248.6
23.8
24
*
R4110
NOMESCO Finland
Physiotherapy
2.7
23.6
205
958
KBV10
NOMESCO Finland
Removal of stent from ureter
37.8
23.2
29
8
Q64.2
ICD-10 Finland
Congenital posterior urethral valves
+∞
23.1
22
*
Q62.11
ICD-10 Finland
Congenital bilateral occlusion of the pelvic ureteral junction
+∞
23.1
22
*
ZXC96
NOMESCO Finland
Robot assisted procedure
13.7
22.7
39
30
127
Kela drug reimbursment
Transplant complication
12.8
22.6
40
33
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
28.5
22.4
30
11
A12AA04
ATC
calcium carbonate; oral
20.4
22.3
33
17
N30.0
ICD-10 Finland
Acute cystitis
3.0
21.8
141
545
KA3EB
NOMESCO Finland
Antegrade pyelography
51.8
21.3
25
5
N18.0
ICD-10 Finland
End-stage renal disease
25.2
21.0
29
12
XKC03
NOMESCO Finland
Water cystometry
7.9
20.0
46
62
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
30.0
19.8
26
9
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
8.6
19.8
43
53
KH1AA
NOMESCO Finland
Urinary tract X-ray examination without contrast
17.4
19.3
30
18
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
15.9
18.1
29
19
R31
ICD-10 Finland
Unspecified haematuria
4.3
17.8
69
176
N13.1
ICD-10 Finland
Hydronephrosis with ureteral stricture, not elsewhere classified
68.6
17.8
20
*
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
17.8
17
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
36.1
16.8
21
6
Q62.8
ICD-10 Finland
Other congenital malformations of ureter
+∞
16.7
16
*
KH1CB
NOMESCO Finland
Urography with X-ray
92.5
16.6
18
*
R50.9
ICD-10 Finland
Fever, unspecified
2.5
16.3
142
644
L04AA06
ATC
mycophenolic acid; systemic
8.9
16.1
34
40
Q62.6
ICD-10 Finland
Malposition of ureter
+∞
15.7
15
*
TKC20
NOMESCO Finland
Catheterisation of bladder
4.2
15.6
61
157
U14
ICPC
Kidney symptom/complaint
12.7
15.5
27
22
N28.8
ICD-10 Finland
Other specified disorders of kidney and ureter
39.1
15.5
19
5
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
29.4
15.3
20
7
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
20.6
15.2
22
11
WX402
NOMESCO Finland
General anaesthesia
2.4
14.8
141
671
ZXA00
NOMESCO Finland
Right side
2.3
14.8
153
756
Q62.12
ICD-10 Finland
Congenital occlusion of ureterovesical orifice
+∞
14.6
14
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
14.6
14.6
24
17
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
13.9
124
569
B03XA02
ATC
darbepoetin alfa; parenteral
12.4
13.7
24
20
KAH62
NOMESCO Finland
Endopyelotomy
+∞
13.6
13
*
J01CA08
ATC
pivmecillinam; oral
1.9
13.4
271
1765
TK800
NOMESCO Finland
Hemodialysis
9.0
13.1
27
31
KAT00
NOMESCO Finland
Extracorporeal shock wave lithotripsy of pelvis of kidney
17.1
13.0
20
12
J01DA01
ATC
[U] cefalexin; systemic
1.8
12.7
382
2829
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
12.6
12.7
22
18
KH1FT
NOMESCO Finland
Exchange of urinary catheter with radiological guidance
132.4
12.5
13
*
7187
FHL
Ureterohydroplasty due to reflux, for example
132.4
12.5
13
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
38.3
12.2
15
*
KBV15
NOMESCO Finland
Cystoscopic change of ureteral stent
38.3
12.2
15
*
XF602
NOMESCO Finland
Bloodpressure monitoring
16.3
12.2
19
12
KAC00
NOMESCO Finland
Nephrectomy
18.5
12.1
18
10
G04BD04
ATC
oxybutynin; oral, transdermal
4.3
12.0
44
107
7143
FHL
Pyeloureteroplasty
47.6
11.9
14
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
11.7
71
258
V03AE01
ATC
polystyrene sulfonate; oral
16.8
11.7
18
11
7532A
ICD-9 Finland
Congenital anomalies of urinary system, Obstructive defects of renal pelvis and ureter
66.2
11.6
13
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
11.6
55
168
Q61.0
ICD-10 Finland
Congenital single renal cyst
+∞
11.5
11
*
KAH30
NOMESCO Finland
Pyeloureteroplasty without division of ureteropelvic junction
+∞
11.5
11
*
J01MA06
ATC
norfloxacin; oral
2.7
11.5
79
313
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
25.5
11.2
15
6
N13.8
ICD-10 Finland
Other obstructive and reflux uropathy
+∞
10.4
10
*
7534X
ICD-9 Finland
Congenital anomalies of urinary system, Other specified anomalies of ureter
+∞
10.4
10
*
KDD52
NOMESCO Finland
Urethroscopic excision of urethral valve
+∞
10.4
10
*
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
10.4
10
*
B03XA01
ATC
erythropoietin; parenteral
12.3
10.4
18
15
KAE12
NOMESCO Finland
Retrograde ureteronephroscopic lithotripsy in pelvis of kidney
19.1
10.3
15
8
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
19.1
10.3
15
8
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.8
10.3
14
6
N30.9
ICD-10 Finland
Cystitis, unspecified
3.3
10.1
51
164
ZXA05
NOMESCO Finland
Left side
2.1
10.1
132
712
137
Kela drug reimbursment
Uraemia requiring dialysis
11.5
10.1
18
16
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
10.0
149
850
L04AD01
ATC
ciclosporin; systemic
5.8
9.6
26
46
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
7.7
9.5
21
28
7219
FHL
Other measure in this category
101.4
9.4
10
*
V03AE02
ATC
sevelamer; oral
30.5
9.4
12
*
Q61.1
ICD-10 Finland
Polycystic kidney, autosomal recessive
+∞
9.4
9
*
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
+∞
9.4
9
*
N26
ICD-10 Finland
Unspecified contracted kidney
+∞
9.4
9
*
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
9.4
9
*
KCF02
NOMESCO Finland
Transluminal endoscopic removal of foreign body from bladder
+∞
9.4
9
*
N20.1
ICD-10 Finland
Calculus of ureter
4.4
9.2
32
75
V03AE03
ATC
lanthanum carbonate; oral
37.2
9.0
11
*
5990C
ICD-9 Finland
Other disorders of urethra and urinary tract, Urinary tract infection, site not specified[INFECTIO VIARUM URINARIUM RECIDIVANS]
24.4
8.9
12
5
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
24.4
8.9
12
5
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.5
8.9
40
119
5990B
ICD-9 Finland
Other disorders of urethra and urinary tract, Urinary tract infection, site not specified[INFECTIO VIARUM URINARIUM ACUTA]
9.7
8.8
17
18
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.7
200
1315
B05DB
ATC
Hypertonic solutions
16.5
8.6
13
8
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.7
8.6
28
62
KCW98
NOMESCO Finland
Other transluminal endoscopic operation on bladder
27.9
8.5
11
*
KBV42
NOMESCO Finland
Cystoscopic incision or excision of ureterocele
91.2
8.4
9
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.6
8.4
36
103
7533X
ICD-9 Finland
Congenital anomalies of urinary system, Other specified anomalies of kidney
+∞
8.3
8
*
Q61.99
ICD-10 Finland
Cystic kidney disease, unspecified
+∞
8.3
8
*
Q61.40
ICD-10 Finland
Renal dysplasia of a kidney (multicystic)
+∞
8.3
8
*
F98.02
ICD-10 Finland
Non-organic nocturnal and diurnal enuresis
9.6
8.3
16
17
J01MA12
ATC
levofloxacin; systemic
2.1
8.2
91
458
B34.9
ICD-10 Finland
Viral infection, unspecified
3.1
8.1
43
145
N30
ICD-10 Finland
Cystitis
2.5
8.1
62
262
H05BX01
ATC
cinacalcet; oral
22.3
8.0
11
5
N20.9
ICD-10 Finland
Urinary calculus, unspecified
5.3
7.9
23
45
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
7.8
225
1569
5AB14
NOMESCO Finland
NA
18.6
7.6
11
6
KDV20
NOMESCO Finland
Submucous urethral injection
25.3
7.6
10
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
81.0
7.4
8
*
N28.1
ICD-10 Finland
Cyst of kidney
13.6
7.4
12
9
WZC30
NOMESCO Finland
Teaching
2.2
7.3
72
342
Q62.1
ICD-10 Finland
Atresia and stenosis of ureter
+∞
7.3
7
*
7186
FHL
Ureteroplasty, narrowing and resection (includes neoimplantation)
+∞
7.3
7
*
KBJ00
NOMESCO Finland
Cutaneous ureterostomy
+∞
7.3
7
*
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
30.4
7.2
9
*
Z99.2
ICD-10 Finland
Dependence on renal dialysis
20.3
7.1
10
5
B05DA
ATC
Isotonic solutions
10.2
7.1
13
13
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.0
236
1705
R39.1
ICD-10 Finland
Other difficulties with micturition
5.1
6.8
20
40
3076C
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Enuresis[YÖ- JA PÄIVÄKASTELU]
40.5
6.8
8
*
N13.2
ICD-10 Finland
Hydronephrosis with renal and ureteral calculous obstruction
40.5
6.8
8
*
R93.4
ICD-10 Finland
Abnormal findings on diagnostic imaging of urinary organs
16.9
6.8
10
6
N19
ICD-10 Finland
Unspecified kidney failure
5.3
6.7
19
37
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.7
6.6
42
160
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
6.5
73
370
Q42.2
ICD-10 Finland
Congenital absence, atresia and stenosis of anus with fistula
70.5
6.4
7
*
R33
ICD-10 Finland
Retention of urine
3.0
6.4
35
122
Z49.0
ICD-10 Finland
Preparatory care for dialysis
14.5
6.4
10
7
C08CA01
ATC
amlodipine; oral
1.7
6.3
131
823
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
6.3
50
215
4AA09
NOMESCO Finland
NA
18.2
6.3
9
5
KAD10
NOMESCO Finland
Heminephrectomy
+∞
6.3
6
*
7188
FHL
Ureteroneocystostomy
+∞
6.3
6
*
Q61.48
ICD-10 Finland
Nonspecified renal dysplasia
+∞
6.3
6
*
Q62.4
ICD-10 Finland
Agenesis of ureter
+∞
6.3
6
*
7536A
ICD-9 Finland
Congenital anomalies of urinary system, Atresia and stenosis of urethra and bladder neck[OBSTRUCTIO URETHRAE ET COLLI VESICAE CONGENITA]
+∞
6.3
6
*
H05BX02
ATC
paricalcitol; systemic
+∞
6.3
6
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
7.1
6.2
14
20
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.9
6.2
24
64
H01AC01
ATC
somatropin; parenteral
5.1
6.2
18
36
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.1
6.1
31
103
5604
FHL
Vascular preparation or cannulation in the operating room
12.7
6.1
10
8
WX892
NOMESCO Finland
Monitored bed care
2.4
6.1
47
201
J01DB01
ATC
cefalexin; oral
1.6
6.0
504
4433
RD210
NOMESCO Finland
NA
3.0
6.0
32
110
205
Kela drug reimbursment
Chronic hypertension
1.9
6.0
93
534

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
367
1701
3.25
55.14
8.1
3.1
22.3
47.0
e6/l
2.17
314
1275
286
1156
3.37
53.82
6.2
2.5
6.7
7.7
e6/l
0.38
267
1011
340
1560
3.14
51.10
7.7
2.9
0.2
0.3
e6/l
1.63
289
1147
238
889
3.45
50.44
5.6
2.8
3.5
2.7
e6/l
0.45
159
466
335
1562
3.05
48.35
7.7
2.9
—
—
—
0
0
267
1095
3.22
48.21
6.2
2.6
549.7
568.9
mosm/kgh2o
0.67
243
938
403
2090
2.98
47.77
9.3
3.6
65.0
53.6
e6/l
0.40
322
1381
346
1681
2.95
45.78
4.8
2.5
—
—
—
0
0
134
366
4.23
44.58
10.8
4.3
103.5
67.6
ng/l
3.68
127
339
32
22
15.14
35.83
3.2
2.3
—
—
—
0
0
590
4100
2.99
35.32
8.4
4.0
—
—
—
0
0
64
114
6.04
34.96
2.3
2.7
—
—
—
0
0
564
3919
2.72
32.04
9.0
4.1
190.8
842.2
e6/l
0.48
19
52
174
735
2.78
27.93
20.4
7.1
1.2
1.1
mmol/l
0.70
168
691
448
2932
2.29
26.85
6.0
3.3
0.0
0.0
estimate
0.00
75
589
452
2981
2.28
26.43
6.1
3.3
0.0
0.0
estimate
0.80
76
585
446
2952
2.24
25.48
8.7
4.5
0.0
0.0
estimate
0.00
74
605
347
2108
2.19
24.18
9.5
5.1
36.0
37.0
g/l
2.39
330
1970
301
1752
2.19
23.12
2.6
2.4
—
—
—
0
0
249
1357
2.24
22.39
4.9
3.3
—
—
—
0
0
23
21
11.26
21.63
4.3
2.7
—
—
—
0
0
131
556
2.64
20.37
5.2
4.8
1.6
1.7
%
0.21
126
511
137
596
2.59
20.25
12.5
6.5
1.0
1.6
mmol/l
1.30
116
469
127
544
2.60
19.33
14.5
9.4
—
—
—
0
0
379
2547
1.98
18.57
17.9
7.0
1.2
1.2
mmol/l
0.13
351
2180
106
430
2.70
17.93
10.8
7.4
23.5
23.9
mmol/l
1.09
99
408
390
2680
1.94
17.56
4.3
4.1
—
—
—
0
0
95
378
2.73
16.65
3.0
3.6
67.7
72.0
e9/l
0.55
69
277
215
1235
2.03
16.02
6.7
4.0
—
—
—
0
0
279
1781
1.90
15.11
6.9
6.6
1.0
1.1
inr
3.97
56
572
136
668
2.26
15.09
6.8
2.3
20.7
23.5
%
1.78
119
588
343
2340
1.85
15.04
17.2
6.8
1.2
1.2
mmol/l
0.31
322
2138
151
785
2.15
14.53
6.2
2.3
12.0
14.2
umol/l
4.32
145
720
239
1468
1.92
14.43
10.2
3.4
7.4
7.4
ph
1.79
37
272
429
3206
1.78
13.30
7.6
4.8
6.3
6.3
mmol/l
0.14
386
2902
55
184
3.14
13.13
2.8
1.6
92.2
107.9
u/ml
—
6
26
57
196
3.06
12.99
2.9
1.6
—
—
—
0
0
218
1345
1.87
12.73
2.6
2.3
—
—
—
0
0
249
1605
1.82
12.62
5.3
3.3
7.3
8.2
mmol/l
2.31
230
1380
61
222
2.90
12.59
2.2
1.5
217.5
221.4
u/ml
0.03
37
118
58
209
2.92
12.18
9.3
12.5
—
—
—
0
0
93
436
2.29
11.40
9.1
8.9
0.3
1.1
mmol/l
1.30
68
346
92
431
2.29
11.30
9.1
9.0
5.0
5.1
kpa
1.09
85
413
92
431
2.29
11.30
9.1
8.9
14.3
13.1
kpa
0.93
85
415
693
6167
2.46
11.24
21.6
11.5
25.9
21.1
mg/l
3.09
573
4606
31
79
4.05
11.11
9.2
2.4
—
—
—
0
0
359
2653
1.67
10.73
6.1
6.0
13.2
11.8
umol/l
0.48
334
2483
56
215
2.73
10.47
6.3
5.0
0.2
0.3
g/l
0.89
41
113
49
178
2.87
10.16
1.7
2.4
1.7
1.4
g/l
1.04
41
155
34
99
3.55
10.12
8.4
2.8
—
—
—
0
0
183
1146
1.79
9.86
5.2
3.3
95.3
169.8
mg/l
0.48
148
764
505
4128
1.67
9.78
10.1
6.6
87.9
81.6
u/l
1.54
489
3854
14
19
7.49
9.72
2.3
2.6
—
—
—
0
0
664
5883
2.05
9.66
25.2
12.3
139.6
139.6
mmol/l
0.08
654
5699
633
5529
1.88
9.47
26.6
14.3
13.6
13.4
%
1.86
628
5428
236
1605
1.68
9.41
8.9
7.5
—
—
—
0
0
376
2879
1.61
9.29
9.8
6.9
0.7
0.7
%
0.07
361
2716
449
3593
1.61
9.19
11.8
9.2
4.0
3.9
e9/l
0.63
395
3119
663
5903
1.99
9.02
25.7
12.3
4.0
3.9
mmol/l
4.37
651
5692
245
1699
1.65
8.99
5.7
2.9
—
—
—
0
0
186
1200
1.73
8.94
6.0
4.1
17.5
10.6
mg/mmol
1.50
148
782
385
2991
1.58
8.76
9.9
7.0
8.6
8.3
%
1.16
370
2832
178
1150
1.72
8.46
4.2
2.9
6883.2
4857.2
umol/l
0.21
166
1011
396
3115
1.57
8.41
9.6
6.7
29.3
30.8
%
1.81
378
2950
32
102
3.23
8.31
1.4
1.2
—
—
—
0
0
380
2972
1.56
8.20
9.8
6.8
2.9
2.8
%
0.29
364
2796
391
3078
1.56
8.20
9.2
6.5
55.7
54.7
%
0.96
374
2922
34
114
3.08
8.13
2.8
2.1
126.0
130.9
g/l
0.68
28
83
33
109
3.12
8.09
3.8
6.8
—
—
—
0
0
229
1597
1.62
8.06
3.5
2.5
63.3
55.0
u/l
2.52
216
1463
287
2113
1.58
8.04
9.0
6.9
—
—
—
0
0
27
79
3.51
8.01
7.1
5.2
—
—
—
0
0
33
111
3.06
7.86
2.8
2.4
—
—
—
0
0
51
216
2.46
7.86
5.7
4.6
0.7
0.7
%
0.31
51
211
395
3136
1.54
7.84
9.4
6.7
0.0
0.0
e9/l
0.28
346
2705
34
117
3.00
7.79
8.4
9.5
1.3
1.2
mmol/l
0.22
28
99
405
3236
1.54
7.78
9.7
7.1
0.2
0.2
e9/l
0.36
359
2842
50
211
2.47
7.76
8.1
11.0
23.6
24.3
mmol/l
0.90
50
200
393
3125
1.54
7.68
9.5
6.7
0.6
0.6
e9/l
1.25
343
2695
130
792
1.77
7.54
9.2
5.3
0.8
0.8
mmol/l
2.49
124
744
112
656
1.83
7.40
3.3
4.0
9.6
7.3
umol/l
0.30
93
547
40
158
2.62
7.12
3.9
3.2
—
—
—
0
0
13
23
5.73
7.08
2.6
2.7
512.8
511.4
min
0.02
13
14
403
3258
1.51
7.05
9.5
6.6
2.0
2.0
e9/l
0.26
357
2875
64
325
2.06
6.43
18.4
7.8
9.7
9.4
kpa
0.65
64
304
228
1662
1.53
6.39
5.7
3.0
2.4
2.4
mmol/l
0.66
204
1482
49
225
2.26
6.33
5.1
3.0
—
—
—
0
0
86
497
1.82
5.92
15.3
6.8
7.4
7.4
ph
0.76
14
33
115
723
1.70
5.92
2.1
2.0
—
—
—
0
0
79
448
1.85
5.77
2.1
1.4
—
—
—
0
0
13
28
4.71
5.75
2.8
2.7
621.5
493.8
ml
0.51
13
15
137
913
1.61
5.61
3.7
3.4
301.9
543.7
ng/l
0.52
96
572
29
111
2.68
5.53
6.6
3.9
—
—
—
0
0
17
47
3.68
5.50
4.9
4.0
—
—
—
0
0
19
57
3.39
5.47
4.6
3.9
—
—
—
0
0
53
267
2.06
5.46
2.4
4.9
21.5
21.8
s
0.17
48
252
374
3082
1.42
5.35
4.5
2.9
85.4
81.4
ug/l
0.23
361
2872
62
334
1.93
5.30
3.7
2.4
—
—
—
0
0
691
6463
1.79
4.95
18.8
10.1
—
—
—
0
0
12
29
4.19
4.64
1.2
1.2
—
—
—
0
0
181
1338
1.46
4.54
6.4
3.5
1.0
1.0
kg/l
0.26
38
178
150
1068
1.50
4.54
2.5
1.6
—
—
—
0
0
14
39
3.64
4.50
1.0
1.2
—
—
—
0
0
408
3482
1.37
4.41
3.4
3.1
—
—
—
0
0
16
50
3.25
4.35
1.9
2.6
—
—
—
0
0
26
108
2.46
4.26
9.4
3.0
1.5
2.5
mmol/l
1.24
15
62
45
235
1.97
4.25
9.2
6.2
—
—
—
0
0
16
51
3.18
4.22
1.9
2.6
4.1
4.0
mmol/l
0.82
16
51
16
51
3.18
4.22
1.9
2.6
107.0
105.9
mmol/l
0.41
16
51
27
115
2.40
4.20
1.9
1.6
—
—
—
0
0
216
1671
1.41
4.20
2.3
1.7
—
—
—
0
0
13
37
3.56
4.06
2.2
2.6
1.4
2.4
u/field
—
7
22
7
7
10.08
4.01
1.7
1.4
264.6
251.4
umol/24h
—
7
7
65
390
1.73
3.98
1.7
1.5
—
—
—
0
0
44
234
1.93
3.96
11.8
8.4
23.0
24.5
mmol/l
1.83
37
218
650
6054
1.52
3.92
23.4
12.4
38.5
40.2
%
5.61
534
4888
10
24
4.21
3.89
2.3
1.3
—
—
—
0
0
22
90
2.49
3.74
1.9
1.8
—
—
—
0
0
22
90
2.49
3.74
1.9
1.8
—
—
—
0
0
22
90
2.49
3.74
1.9
1.8
—
—
—
0
0
22
90
2.49
3.74
1.9
1.8
—
—
—
0
0
61
367
1.72
3.71
6.4
3.5
—
—
—
0
0
145
1066
1.45
3.70
1.5
1.4
20.5
20.4
nmol/l
0.01
136
907
14
45
3.15
3.66
3.4
11.6
9.9
12.3
%
2.74
14
45
53
309
1.77
3.60
2.8
2.9
65.4
66.6
g/l
0.44
53
285
42
228
1.89
3.58
1.8
1.7
—
—
—
0
0
98
670
1.53
3.57
1.8
1.5
—
—
—
0
0
11
31
3.59
3.49
1.1
1.1
—
—
—
0
0
11
32
3.47
3.34
1.1
1.0
—
—
—
0
0
251
2060
1.33
3.23
1.9
1.9
—
—
—
0
0
8
15
5.38
3.19
6.5
11.1
45.0
48.2
%
—
8
15
40
225
1.82
3.09
2.2
1.6
1.1
1.2
g/l
0.47
40
213
39
218
1.83
3.07
2.2
1.6
0.2
0.2
g/l
0.01
39
207
727
7020
1.90
3.04
30.2
16.7
255.3
258.3
e9/l
0.66
713
6819
63
409
1.59
2.91
17.6
7.1
—
—
—
0
0
25
122
2.08
2.90
5.6
3.8
26.6
27.6
mg/l
0.06
20
79
727
7029
1.86
2.89
30.1
16.6
4.5
4.6
e12/l
2.00
712
6817
22
102
2.19
2.89
3.6
2.5
124.7
101.9
ug/min
0.11
15
60
6
9
6.71
2.87
1.2
1.7
—
—
—
0
0
727
7031
1.85
2.86
30.1
16.6
6.8
6.7
e9/l
0.92
714
6816
12
42
2.89
2.76
3.2
2.8
0.7
0.8
nmol/l
0.65
12
30
38
219
1.77
2.74
1.8
1.2
—
—
—
0
0
89
636
1.45
2.65
1.2
1.2
—
—
—
0
0
37
214
1.77
2.64
1.2
1.5
—
8.7
—
0
7
26
137
1.93
2.48
1.2
1.2
—
—
—
0
0
13
51
2.58
2.45
1.1
1.6
—
—
—
0
0
48
305
1.61
2.45
1.5
1.5
—
—
—
0
0
33
189
1.78
2.45
1.2
1.2
—
—
—
0
0
333
2914
1.25
2.45
13.1
9.1
0.0
0.0
e9/l
0.24
267
2339
184
1497
1.30
2.44
2.8
2.3
3.1
2.9
mg/l
0.40
162
1289
111
844
1.37
2.33
1.4
1.4
368.4
556.6
titre
1.03
19
151
169
1369
1.30
2.31
1.7
1.7
1.4
1.3
mmol/l
0.47
159
1166
192
1588
1.28
2.24
7.6
3.5
0.0
0.0
estimate
0.88
68
587
28
159
1.79
2.16
2.7
3.1
369.1
1025.4
u/ml
0.32
19
136
53
358
1.52
2.11
1.2
1.2
—
—
—
0
0
10
37
2.73
2.11
1.4
1.1
—
—
—
0
0
9
32
2.83
2.00
1.1
1.1
357.3
151.8
iu/ml
—
9
32
45
297
1.55
2.00
1.5
1.4
—
—
—
0
0
244
2102
1.24
1.98
2.6
2.2
—
—
—
0
0
45
299
1.54
1.95
1.5
1.5
—
—
—
0
0
10
39
2.58
1.92
1.6
4.9
—
—
—
0
0
128
1025
1.30
1.91
2.4
2.6
115.8
117.9
ug/g
0.03
99
804
8
28
2.88
1.86
1.3
3.0
—
—
—
0
0
17
86
2.00
1.86
1.2
1.3
—
—
—
0
0
22
122
1.83
1.86
1.9
1.9
—
—
—
0
0
91
697
1.35
1.85
2.2
1.6
—
—
—
0
0
6
17
3.55
1.84
1.0
1.1
—
—
—
0
0
6
17
3.55
1.84
1.3
1.4
—
—
—
0
0
31
191
1.65
1.83
1.5
1.3
—
—
—
0
0
502
4673
1.22
1.83
5.8
4.6
37.7
38.1
mmol/mol
0.43
478
4380
8
29
2.78
1.79
2.8
1.5
—
—
—
0
0
590
5591
1.25
1.78
4.9
4.4
1.9
1.8
mu/l
1.18
559
5176
462
4274
1.21
1.76
4.7
3.8
10.7
9.6
mm/h
0.99
443
3925
53
376
1.44
1.70
3.5
4.3
4.0
18.0
ug/l
0.65
44
304
72
540
1.37
1.69
1.2
1.2
102.3
140.8
iu/ml
0.74
26
205
35
228
1.56
1.68
2.5
2.3
—
—
—
0
0
114
916
1.29
1.67
1.7
1.6
119608300.4
34710111.1
pmol/l
0.32
102
775
55
397
1.42
1.62
1.7
1.6
385.3
306.6
mu/l
0.34
50
359
5
14
3.59
1.61
1.8
1.1
—
—
—
0
0
86
669
1.32
1.60
1.3
1.2
—
—
—
0
0
88
689
1.31
1.57
2.0
1.9
—
—
—
0
0
220
1918
1.21
1.55
1.8
1.7
95.3
97.6
pmol/l
0.30
113
988
568
5390
1.21
1.53
4.6
3.9
2.7
2.8
mmol/l
2.07
546
5017
509
4784
1.19
1.51
4.4
3.8
14.8
14.5
pmol/l
1.56
477
4326
13
65
2.02
1.49
3.9
4.9
—
—
—
0
0
60
448
1.37
1.47
2.7
2.7
0.8
0.7
ug/l
0.41
40
272
7
28
2.51
1.45
2.7
3.2
—
—
—
0
0
50
364
1.40
1.43
1.8
1.6
41.0
18.6
iu/l
1.81
40
281
6
23
2.62
1.37
2.7
2.2
2411.7
2493.3
ml
—
6
23
232
2054
1.19
1.36
1.7
1.7
—
—
—
0
0
54
714
0.74
1.36
1.2
1.3
—
—
—
0
0
5
17
2.95
1.36
1.0
1.1
4.7
6.1
mg/g
—
5
17
10
47
2.14
1.34
5.0
5.8
—
—
—
0
0
52
386
1.37
1.34
2.3
2.4
3.8
4.1
e9/l
0.55
46
328
656
6345
1.25
1.32
13.0
8.8
24.8
25.9
u/l
0.98
642
6118
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
12
62
1.95
1.28
1.0
1.2
11.4
20.4
u/l
0.92
12
54
10
48
2.10
1.28
1.0
1.3
—
—
—
0
0
15
84
1.80
1.27
1.2
1.2
—
—
—
0
0
8
35
2.30
1.27
1.0
1.1
—
—
—
0
0
52
391
1.35
1.25
7.0
4.7
0.0
0.1
%
0.82
21
91
139
1185
1.21
1.23
1.7
1.6
—
—
—
0
0
11
56
1.98
1.22
1.2
1.3
—
—
nmol/l
—
0
0
8
37
2.17
1.21
1.0
1.1
—
—
—
0
0
86
697
1.26
1.21
1.2
1.2
—
—
—
0
0
143
1229
1.20
1.17
2.1
2.4
1.8
1.0
mg/l
0.41
114
900
543
5181
1.17
1.16
4.1
3.6
5.7
5.7
mmol/l
0.40
507
4744
7
30
2.35
1.12
2.7
3.1
—
—
—
0
0
11
58
1.91
1.12
1.0
1.2
34.4
36.5
mg/l
0.09
11
44
10
51
1.97
1.11
1.0
1.0
—
—
—
0
0
155
1349
1.19
1.11
2.0
2.2
147.7
231.5
u/l
0.92
148
1273
7
31
2.27
1.10
1.9
2.2
—
—
—
0
0
185
1635
1.17
1.10
3.2
3.2
37.0
33.4
ng/l
0.10
95
913
5
21
2.39
1.09
1.4
2.4
200.4
126.9
ug/l
—
5
21
5
21
2.39
1.09
1.0
1.6
—
—
—
0
0
43
323
1.35
1.06
1.2
1.3
—
—
—
0
0
32
230
1.41
1.03
2.4
2.3
—
—
—
0
0
98
824
1.22
1.01
3.7
2.6
2.4
2.4
mmol/l
0.04
81
713
21
139
1.53
1.01
6.7
3.6
24.0
23.3
nmol/l
0.08
21
134
54
426
1.29
0.97
7.0
4.5
0.5
0.9
%
1.17
26
119
67
544
1.25
0.96
1.7
1.4
—
—
—
0
0
552
5303
1.15
0.96
4.3
3.5
1.4
1.5
mmol/l
0.77
532
4955
555
5336
1.15
0.95
4.4
3.6
4.5
4.6
mmol/l
2.15
536
5011
16
101
1.60
0.94
1.3
1.2
2.4
4.0
u/ml
—
7
47
50
394
1.29
0.92
6.9
4.1
0.4
0.4
%
0.05
17
83
95
807
1.20
0.90
4.7
4.4
2.2
2.2
ug/l
0.02
90
716
6
29
2.08
0.89
1.7
1.4
—
—
—
0
0
10
56
1.80
0.88
2.0
1.7
32.7
32.1
pg
—
10
56
8
43
1.87
0.87
2.1
1.8
5.3
6.0
mmol/l
—
8
31
528
5077
1.13
0.84
3.9
3.3
1.2
1.2
mmol/l
0.46
509
4738
28
207
1.37
0.80
1.9
3.0
7.2
6.8
umol/l
0.07
22
163
10
58
1.73
0.80
1.3
1.2
—
—
—
0
0
50
403
1.26
0.79
7.4
4.6
0.0
0.1
%
0.73
25
107
11
174
0.63
0.77
1.5
1.2
—
—
—
0
0
6
34
1.77
0.76
2.0
1.6
0.9
0.9
g/l
—
6
34
7
41
1.71
0.70
1.9
3.4
27.4
24.3
umol/l
—
7
41
21
152
1.39
0.69
1.1
2.4
1.7
6.1
e6/l
1.74
16
115
21
152
1.39
0.69
1.1
2.4
410.6
236.4
e6/l
0.25
16
119
5
27
1.86
0.68
2.8
2.7
9.4
10.9
mg/l
—
5
21
28
215
1.31
0.66
1.1
1.1
—
—
—
0
0
21
155
1.36
0.63
1.2
1.1
—
5.8
—
0
11
157
1432
1.12
0.61
8.9
4.3
—
—
—
0
0
8
51
1.57
0.60
1.4
2.1
—
—
—
0
0
8
51
1.57
0.60
1.1
2.8
4.0
3.1
nmol/l
—
8
51
0
20
0.00
0.60
0.0
1.4
—
92.7
—
0
14
12
80
1.51
0.60
1.3
3.5
—
—
—
0
0
68
589
1.17
0.57
2.3
2.3
7476.2
4491.7
u/l
0.38
28
228
14
98
1.44
0.56
1.8
1.8
—
—
—
0
0
8
55
1.46
0.56
1.1
1.1
—
—
—
0
0
6
38
1.58
0.54
4.7
2.0
—
—
—
0
0
9
61
1.48
0.54
2.6
1.4
—
—
—
0
0
16
117
1.38
0.52
6.6
3.6
3.2
3.9
e9/l
0.73
16
117
9
64
1.41
0.51
2.0
1.5
292.6
286.8
mosm/kgh2o
—
9
42
22
171
1.29
0.50
1.8
1.8
3.0
6.2
iu/l
—
8
54
19
145
1.32
0.49
1.4
1.3
236.6
351.0
ug/g
1.46
14
82
18
233
0.77
0.47
1.1
1.2
6.3
3.7
u/ml
—
7
74
16
122
1.32
0.42
9.2
3.6
49.8
54.9
%
0.65
16
122
63
559
1.14
0.41
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
7.5
—
—
—
0
0
16
123
1.31
0.40
1.3
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
1529.6
1721.3
miu/ml
—
5
34
183
1723
1.08
0.39
1.6
1.5
2.0
2.0
g/l
0.31
113
1001
8
61
1.31
0.39
1.5
1.3
30.6
38.3
nmol/l
—
8
52
10
71
1.41
0.39
1.5
1.3
—
—
—
0
0
10
71
1.41
0.39
2.6
2.1
—
—
—
0
0
28
334
0.83
0.39
1.4
1.6
—
—
—
0
0
63
562
1.13
0.39
8.5
3.3
—
—
—
0
0
9
68
1.33
0.37
1.3
1.8
—
—
—
0
0
9
70
1.29
0.36
1.0
1.3
—
—
—
0
0
19
234
0.81
0.36
1.1
1.2
1.9
1.4
u/ml
0.18
12
145
10
73
1.37
0.34
1.4
1.2
—
—
—
0
0
41
360
1.15
0.33
1.3
1.4
—
—
—
0
0
47
418
1.13
0.32
8.7
3.8
—
—
—
0
0
22
262
0.83
0.31
1.0
1.3
0.5
2.3
u/ml
1.66
12
144
201
1917
1.07
0.31
1.4
1.4
1.1
1.7
u/ml
0.78
46
460
42
371
1.14
0.31
1.4
1.3
240.2
253.6
miu/ml
0.08
19
190
25
293
0.85
0.30
3.6
2.4
24.8
45.3
u/ml
1.12
25
281
7
54
1.30
0.30
1.4
1.3
—
—
—
0
0
8
66
1.21
0.26
1.3
2.6
—
—
—
0
0
12
95
1.27
0.26
1.0
1.1
—
—
—
0
0
13
105
1.24
0.25
1.4
1.1
—
—
—
0
0
17
142
1.20
0.24
1.1
2.5
—
—
—
0
0
19
162
1.18
0.23
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.0
10.8
9.8
mu/l
—
5
35
19
163
1.17
0.21
1.1
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
68
634
1.08
0.21
1.7
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
26.9
—
0.5
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
14
117
1.20
0.20
1.4
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
4.3
—
0
8
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
16
136
1.18
0.20
1.4
1.4
—
—
—
0
0
64
598
1.08
0.19
2.1
2.0
—
—
—
0
0
6
52
1.15
0.19
1.0
1.2
—
—
—
0
0
6
52
1.15
0.19
1.3
1.4
—
—
—
0
0
13
153
0.85
0.18
1.1
1.1
13.5
7.0
u/ml
—
8
82
7
59
1.19
0.18
1.1
1.1
—
—
—
0
0
7
62
1.13
0.17
1.7
2.0
—
—
—
0
0
130
1250
1.05
0.17
3.9
3.2
—
—
—
0
0
100
955
1.05
0.17
1.3
1.3
14.0
25.5
iu/ml
2.63
28
276
5
69
0.72
0.17
1.2
1.2
—
—
—
0
0
11
130
0.84
0.16
1.4
1.2
—
—
—
0
0
145
1401
1.04
0.16
1.9
1.8
—
—
—
0
0
53
497
1.07
0.15
2.0
2.0
—
—
—
0
0
7
89
0.78
0.14
1.6
1.6
—
—
—
0
0
46
431
1.07
0.14
1.4
1.3
—
—
—
0
0
26
237
1.10
0.14
1.8
1.7
—
—
—
0
0
41
437
0.93
0.13
2.4
2.6
—
—
—
0
0
27
291
0.93
0.11
2.6
2.5
—
—
—
0
0
5
45
1.11
0.10
1.0
1.2
—
—
—
0
0
18
164
1.10
0.09
11.8
4.3
—
—
—
0
0
13
143
0.91
0.07
1.5
1.6
0.3
0.4
nmol/l
0.19
13
122
66
639
1.04
0.07
2.1
1.9
—
—
—
0
0
8
94
0.85
0.06
5.9
5.3
374.6
400.8
umol/l
—
8
85
29
303
0.96
0.05
1.2
1.1
—
—
—
0
0
66
644
1.03
0.05
2.1
1.9
—
—
—
0
0
34
328
1.04
0.04
1.8
1.7
15.8
8.0
u/l
0.86
28
248
66
646
1.02
0.04
2.2
1.9
—
—
—
0
0
65
639
1.02
0.02
2.1
1.9
—
—
—
0
0
94
929
1.01
0.02
1.3
1.2
13.3
8.7
u/ml
0.19
32
361
74
734
1.01
0.00
1.6
1.6
1342.8
1188.6
nmol/l
0.42
59
565
21
205
1.02
0.00
1.2
1.2
—
—
—
0
0
202
2024
1.00
0.00
2.7
2.4
—
—
—
0
0
18
179
1.01
0.00
1.3
1.6
40.4
39.8
nmol/l
0.05
18
174
39
392
0.99
0.00
1.2
1.2
—
—
—
0
0
16
159
1.01
0.00
6.0
8.1
—
—
—
0
0
11
108
1.02
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.2
—
32.7
—
0
9
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
55
0.91
0.00
1.0
1.4
—
—
—
0
0
5
50
1.00
0.00
1.4
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
12.4
—
—
—
0
0
0
8
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
0.00
3.3
4.9
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
190.4
—
0
5
5
50
1.00
0.00
1.6
1.3
—
—
—
0
0
5
58
0.86
0.00
1.4
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
9
99
0.91
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
20.7
—
0
5
6
64
0.94
0.00
1.2
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER and mortality.

Females

Parameter HR [95% CI] p-value
Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER 1.465 [1.2, 1.79] < 0.001
Birth year 0.993 [0.98, 1.0] 0.145

During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 4672 females with Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER died.

Males

Parameter HR [95% CI] p-value
Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER 1.668 [1.31, 2.13] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 4660 males with Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER.

N-year risk Females Males
1 0.093% 0.297%
5 0.765% 1.81%
10 1.936% 4.479%
15 3.673% 8.582%
20 6.517% 15.033%

Relationships between endpoints

Index endpoint: Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER – Congenital obstructive defects of renal pelvis and congenital malformations of ureter

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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