No definition available.
Other specified congenital malformation syndromes affecting multiple systems
EFO MESH Endpoint Browser PheWeb
Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
619 |
4. Check minimum number of eventsNone |
619 |
5. Include endpointsNone |
619 |
6. Filter based on genotype QC (FinnGen only) |
619 |
Control definitions (FinnGen only)
- Control exclude
- Q17_OTHER_CONGEN_MALFO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q8
- Name in latin
- Alia syndromata malformationum congenitarum specificata, systemata multa afficientia
Similar endpoints
↥List of similar endpoints to
Other specified congenital malformation syndromes affecting multiple systems
based on the number of shared cases.
Similar with more cases:
- Exclusion endpoint for clefts
- Clefts and syndromes for tooth agenesis exclusion, including avohilmo
- Other congenital malformations
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5896 | 2910 | 2971 |
| Only index persons | 4570 | 2275 | 2295 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.08 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 7.85 | 8.55 | 7.03 |
| Only index persons | 11.81 | 12.91 | 10.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 619 | 332 | 287 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.13 |
| Median age at first event (years) | 22.25 | 23.53 | 20.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 563
- Matched controls
- 5630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q87.4
ICD-10 Finland
Marfan syndrome
+∞
200.2
180
*
Z31.5
ICD-10 Finland
Genetic counselling
23.5
162.5
248
182
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
+∞
121.3
112
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
8.5
73.5
181
298
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
46.9
66.6
81
20
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.9
59.8
198
474
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
52.8
269
991
Q87.09
ICD-10 Finland
Other congenital malformations that mainly affect the appearance of the face
484.3
45.9
45
*
Q87.80
ICD-10 Finland
Alport syndrome
+∞
45.4
43
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.7
44.3
179
509
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
97.5
41.4
45
5
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
14.6
40.8
70
54
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.1
39.0
180
572
Q87.14
ICD-10 Finland
Noonan's syndrome
+∞
37.9
36
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
37.8
266
1186
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
5.9
36.4
111
226
R4110
NOMESCO Finland
Physiotherapy
3.4
35.6
224
907
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.2
35.6
159
485
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
10.3
35.5
72
79
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.7
35.4
136
358
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
7.7
35.2
86
129
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
101.5
35.2
38
*
F83
ICD-10 Finland
Mixed specific developmental disorders
10.2
32.6
66
72
Q87.21
ICD-10 Finland
Klippel-Trénaunay-Weber syndrome
+∞
31.5
30
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.2
30.3
203
841
PD5BD
NOMESCO Finland
Extensive CT of aorta
28.5
29.7
40
15
B01AA03
ATC
warfarin; systemic
5.4
29.7
96
207
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.2
29.3
98
219
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.9
29.0
103
246
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
23.8
28.2
40
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.5
27.9
88
184
R62.0
ICD-10 Finland
Delayed milestone
8.4
27.0
61
80
ZXA10
NOMESCO Finland
Bilateral
3.4
26.9
150
536
H01AC01
ATC
somatropin; parenteral
9.4
26.1
55
64
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
272.0
25.9
26
*
Q87.19
ICD-10 Finland
Congenital malformation syndromes predominantly associated with short stature
+∞
25.2
24
*
Q87.06
ICD-10 Finland
Velocardiofacial syndrome
+∞
25.2
24
*
I71.00
ICD-10 Finland
Dissecting aneurysm of aorta (ruptured) [any part]
+∞
24.1
23
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
24.0
136
488
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
16.9
24.0
38
24
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
5.1
23.8
79
174
H27.1
ICD-10 Finland
Dislocation of lens
130.3
23.8
25
*
H52.1
ICD-10 Finland
Myopia
6.2
23.6
66
118
I34.1
ICD-10 Finland
Mitral (valve) prolapse
14.8
23.4
39
28
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
21.2
23.3
34
17
I71.09
ICD-10 Finland
Aortic dissection [regardless of location]
67.8
23.0
26
*
WX872
NOMESCO Finland
Intensive care
9.6
22.8
47
53
WX002
NOMESCO Finland
Sedation and analgesia
3.4
22.7
122
418
XF404
NOMESCO Finland
Ambulatory ECG
4.6
22.5
82
199
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
22.3
149
596
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
10.3
22.2
44
46
H52.2
ICD-10 Finland
Astigmatism
7.8
21.8
51
71
ZXA00
NOMESCO Finland
Right side
2.9
21.2
148
606
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.4
20.6
64
130
C03CA01
ATC
furosemide; systemic
3.7
20.4
96
295
Q89.7
ICD-10 Finland
Multiple congenital malformations, not elsewhere classified
+∞
19.9
19
*
I71.01
ICD-10 Finland
Aneurysm of the descending aorta
206.6
19.7
20
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.4
19.5
73
182
101
Kela drug reimbursment
Anterior pituitary hypofunction
9.9
19.4
39
42
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
20.9
19.2
28
14
Q87.16
ICD-10 Finland
Mulibrey nanism
+∞
18.8
18
*
Q87.8
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
+∞
18.8
18
*
C07AB07
ATC
bisoprolol; oral
2.5
18.7
180
884
201
Kela drug reimbursment
Chronic cardiac insufficiency
8.4
18.6
41
52
UDC00
NOMESCO Finland
Ear microscopy
4.1
18.4
75
202
TPH07
NOMESCO Finland
Cathetrisation of artery
3.7
18.4
87
267
C01AA05
ATC
digoxin; systemic
10.6
18.1
35
35
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
34.1
18.1
23
7
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
18.1
146
649
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
12.5
18.0
32
27
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
4.6
18.0
65
156
DFF00
NOMESCO Finland
Pure tone audiometry
4.5
18.0
66
161
ZXA05
NOMESCO Finland
Left side
2.8
17.8
129
536
Q87.30
ICD-10 Finland
Syndrome Beckwith-Wiedemann
+∞
17.8
17
*
7598B
ICD-9 Finland
Other and unspecified congenital anomalies, Other specified anomalies[SYNDROMA MARFAN]
+∞
17.8
17
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
8.4
17.3
38
48
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.3
16.9
94
326
Q82.50
ICD-10 Finland
Naevus flammeus
+∞
16.7
16
*
RL140
NOMESCO Finland
NA
11.2
16.6
31
29
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
3.8
16.5
73
211
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
16.1
142
659
P85
ICPC
Mental retardation
12.7
16.0
28
23
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
9.1
15.9
33
38
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
15.8
125
544
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.4
15.6
41
68
WX402
NOMESCO Finland
General anaesthesia
2.5
15.6
145
688
WX892
NOMESCO Finland
Monitored bed care
3.7
15.5
70
206
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
20.7
15.2
22
11
301
Kela drug reimbursment
Growth hormone
11.2
15.1
28
26
UGC02
NOMESCO Finland
Rigid bronchoscopy
17.0
14.9
23
14
SAA04
NOMESCO Finland
Special inverstigation of mouth
3.2
14.8
83
289
75988
ICD-8 Finland
Congenital syndromes affecting multiple systems, Aliae definitae
+∞
14.6
14
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.1
14.6
84
298
XFE00
NOMESCO Finland
Epicardial ultrasonography
10.4
14.6
28
28
B01AB05
ATC
enoxaparin; parenteral
2.5
14.6
129
596
FM2CE
NOMESCO Finland
NA
4.3
14.4
54
135
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
3.1
14.3
82
290
R4130
NOMESCO Finland
Speech therapy
5.5
14.2
42
81
Q35.1
ICD-10 Finland
Cleft hard palate
43.6
14.2
17
*
C09CA01
ATC
losartan; oral
2.9
14.0
91
350
C07AB03
ATC
atenolol; systemic
8.3
13.7
30
38
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
8.3
13.7
30
38
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.7
13.7
29
35
Q87.26
ICD-10 Finland
VATER association
+∞
13.6
13
*
Q87.0
ICD-10 Finland
Congenital malformation syndromes predominantly affecting facial appearance
+∞
13.6
13
*
Q21.10
ICD-10 Finland
Persistent ostium secundum
6.7
13.6
34
53
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.5
13.5
66
207
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
16.7
13.5
21
13
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
26.4
13.4
18
7
SPAT1229
SPAT
Assessment of need for aid
5.4
13.1
39
76
A12AA04
ATC
calcium carbonate; oral
9.1
13.1
27
31
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
9.7
13.1
26
28
TJD20
NOMESCO Finland
Change of gastrostomy tube
10.4
13.1
25
25
R4120
NOMESCO Finland
Occupational therapy
3.8
13.1
56
158
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.0
13.0
42
90
EBA15
NOMESCO Finland
Extraction of large number of teeth
5.4
13.0
39
77
KA1AE
NOMESCO Finland
Kidney ultrasound examination
8.3
12.9
28
35
L28
ICPC
Limited function/disability (L)
3.3
12.9
67
221
R1260
NOMESCO Finland
Evaluation of communicative skills
9.3
12.8
26
29
TFP20
NOMESCO Finland
Cardiodefibrillation
5.1
12.8
40
83
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
6.2
12.7
34
58
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.1
12.7
50
131
Q35.71
ICD-10 Finland
Submucous cleft palate
71.4
12.6
14
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
9.0
12.6
26
30
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
12.5
12
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
8.7
12.4
26
31
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
10.8
12.3
23
22
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
14.7
12.3
20
14
XA800
NOMESCO Finland
Neuropsychological investigation
3.3
12.3
63
205
H65.3
ICD-10 Finland
Chronic mucoid otitis media
3.2
12.3
68
233
JDB10
NOMESCO Finland
Percutaneous gastrostomy
10.4
12.1
23
23
XF640
NOMESCO Finland
NA
10.4
12.1
23
23
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.0
12.0
29
43
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
7.0
12.0
29
43
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.4
12.0
43
103
RS222
NOMESCO Finland
NA
8.2
11.9
26
33
GD1AD
NOMESCO Finland
Thorax CT examination
5.8
11.8
33
60
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
16.8
11.7
18
11
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
30.7
11.7
15
5
I50.9
ICD-10 Finland
Heart failure, unspecified
4.7
11.7
39
87
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
66.2
11.6
13
*
C03DA01
ATC
spironolactone; oral
3.8
11.6
49
137
XF402
NOMESCO Finland
ECG with work load test
3.6
11.5
53
159
Q87.28
ICD-10 Finland
Congenital malformation syndromes predominantly involving limbs
+∞
11.5
11
*
D82.1
ICD-10 Finland
Di George syndrome
+∞
11.5
11
*
Q87.04
ICD-10 Finland
Syndrome Robin
+∞
11.5
11
*
Q87.03
ICD-10 Finland
Syndrome Goldenhar
+∞
11.5
11
*
7597A
ICD-9 Finland
Other and unspecified congenital anomalies, Multiple congenital anomalies, so described
+∞
11.5
11
*
Q87.15
ICD-10 Finland
Prader-Willi syndrome
+∞
11.5
11
*
Q87.5
ICD-10 Finland
Other congenital malformation syndromes with other skeletal changes
+∞
11.5
11
*
Q87.1
ICD-10 Finland
Congenital malformation syndromes predominantly associated with short stature
+∞
11.5
11
*
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
122.2
11.5
12
*
I71.1
ICD-10 Finland
Thoracic aortic aneurysm, ruptured
122.2
11.5
12
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
11.3
119
591
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
11.3
53
162
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
11.0
109
525
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
5.1
11.0
34
70
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
10.8
260
1786
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
61.1
10.7
12
*
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
10.6
69
264
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.2
10.6
32
64
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
6.7
10.6
26
40
RS220
NOMESCO Finland
NA
6.1
10.5
28
48
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
10.5
44
122
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
111.8
10.4
11
*
Q87.38
ICD-10 Finland
Syndrome Weaver
+∞
10.4
10
*
FCD60
NOMESCO Finland
Resection of thoracoabdominal aorta and reimplantation of branches
+∞
10.4
10
*
Q87.31
ICD-10 Finland
Syndrome Sotos
+∞
10.4
10
*
R5120
NOMESCO Finland
Preparation of an aid
9.0
10.3
21
24
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
9.8
10.3
20
21
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
19.2
10.3
15
8
DFF20
NOMESCO Finland
Audiometry for children
6.8
10.3
25
38
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
13.4
10.2
17
13
RT160
NOMESCO Finland
NA
11.6
10.1
18
16
H52.0
ICD-10 Finland
Hypermetropia
4.3
10.0
36
87
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
7.2
9.9
23
33
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
5.1
9.9
30
61
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
9.0
9.8
20
23
EB1WA
NOMESCO Finland
NA
10.9
9.8
18
17
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.9
9.8
40
109
F80.1
ICD-10 Finland
Expressive language disorder
5.7
9.8
27
49
CG2T4
NOMESCO Finland
Topography assessment of cornea
13.7
9.7
16
12
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
9.7
135
757
A11CC03
ATC
alfacalcidol; systemic
5.4
9.6
28
54
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
5.4
9.6
28
54
H53.0
ICD-10 Finland
Amblyopia ex anopsia
5.4
9.6
28
54
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
8.6
9.6
20
24
TK800
NOMESCO Finland
Hemodialysis
7.3
9.6
22
31
ZX120
NOMESCO Finland
Intravenous
2.7
9.6
66
261
4122
FHL
Tympanostomy (tympanic tube)
5.1
9.5
29
59
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
9.5
49
161
Z97.4
ICD-10 Finland
Presence of external hearing-aid
7.7
9.5
21
28
Q87.84
ICD-10 Finland
Williams syndrome
101.5
9.4
10
*
Q99.8
ICD-10 Finland
Other specified chromosome abnormalities
17.9
9.4
14
8
FCC50
NOMESCO Finland
Resection and reconstruction of descending aorta using tube graft
+∞
9.4
9
*
H27.0
ICD-10 Finland
Aphakia
+∞
9.4
9
*
75980
ICD-8 Finland
Congenital syndromes affecting multiple systems, Syndroma Marfan, arachnodactylia
+∞
9.4
9
*
Q27.4
ICD-10 Finland
Congenital phlebectasia
22.1
9.4
13
6
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.1
9.4
50
169
WX882
NOMESCO Finland
High dependency care
3.0
9.2
54
194
J01MA12
ATC
levofloxacin; systemic
2.5
9.2
73
314
A03FA02
ATC
cisapride; oral, rectal
3.6
9.1
40
117
ZXC12
NOMESCO Finland
Pulse colorlaser
37.3
9.0
11
*
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
7.6
9.0
20
27
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
18.9
9.0
13
7
H81
ICPC
Excessive ear wax
2.6
8.9
64
261
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.9
8.9
55
203
Z50.5
ICD-10 Finland
Speech therapy
3.5
8.9
40
119
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
5.8
8.8
24
43
N02AX02
ATC
tramadol; systemic, rectal
1.9
8.8
162
1002
K83
ICPC
Heart valve disease NOS
14.3
8.7
14
10
Q21.30
ICD-10 Finland
Tetralogy of Fallot
14.3
8.7
14
10
Q76.30
ICD-10 Finland
Hemivertebra fusion or failure of segmentation with scoliosis
50.7
8.7
10
*
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
50.7
8.7
10
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.3
8.7
22
36
K03.66
ICD-10 Finland
Tooth plaque
2.4
8.7
76
345
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
8.6
49
172
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
8.4
8.6
18
22
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
8.6
145
867
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
8.6
35
96
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
8.6
64
266
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
16.6
8.6
13
8
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
5.3
8.6
25
49
62
HP
Catheterization and pressure measurement of the right side of the heart
27.9
8.5
11
*
Q66.0
ICD-10 Finland
Talipes equinovarus
27.9
8.5
11
*
PDG51
NOMESCO Finland
Bypass from aorta to iliac artery for aneurysm
91.2
8.4
9
*
7598X
ICD-9 Finland
Other and unspecified congenital anomalies, Other specified anomalies[ANOMALIAE CONGENITAE ALIAE DEFINITAE]
91.2
8.4
9
*
Q67.0
ICD-10 Finland
Facial asymmetry
91.2
8.4
9
*
Q79.8
ICD-10 Finland
Other congenital malformations of musculoskeletal system
+∞
8.3
8
*
Q87.10
ICD-10 Finland
Aarskog syndrome
+∞
8.3
8
*
Q87.82
ICD-10 Finland
Zellweger syndrome
+∞
8.3
8
*
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
8.3
8
*
PD5AD
NOMESCO Finland
CT of aorta
11.0
8.3
15
14
RL130
NOMESCO Finland
NA
6.6
8.2
20
31
EEC05
NOMESCO Finland
Le Fort I osteotomy
14.7
8.2
13
9
Z94.0
ICD-10 Finland
Kidney transplant status
6.2
8.2
21
35
RT150
NOMESCO Finland
NA
6.2
8.2
21
35
WX140
NOMESCO Finland
Parabulbar anesthesy
6.2
8.2
21
35
AA1AD
NOMESCO Finland
CT of head and brain
2.2
8.2
82
397
R50.9
ICD-10 Finland
Fever, unspecified
2.0
8.1
111
611
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
11.9
8.1
14
12
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
33.8
8.1
10
*
M41.5
ICD-10 Finland
Other secondary scoliosis
33.8
8.1
10
*
N18.8
ICD-10 Finland
Other chronic renal failure
6.4
8.1
20
32
R04.0
ICD-10 Finland
Epistaxis
3.5
8.1
36
107
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.7
8.0
54
211
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
3.5
8.0
36
108
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
7.9
7.9
17
22
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
5.5
7.9
22
41
K84
ICPC
Heart disease other
6.2
7.9
20
33
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.1
7.9
42
143
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
7.8
39
126
127
Kela drug reimbursment
Transplant complication
5.0
7.8
24
50
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
7.8
94
495
C07AA07
ATC
sotalol; systemic
6.0
7.7
20
34
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
15.3
7.7
12
8
Q27.3
ICD-10 Finland
Peripheral arteriovenous malformation
45.5
7.7
9
*
Q27.88
ICD-10 Finland
Other specified congenital malformation of peripheral vascular system
45.5
7.7
9
*
H61.2
ICD-10 Finland
Impacted cerumen
3.4
7.7
36
111
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
7.6
7.7
17
23
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.7
7.6
52
206
Q82.58
ICD-10 Finland
Congenital non-neoplastic naevus
25.3
7.6
10
*
RD210
NOMESCO Finland
NA
3.1
7.6
41
141
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.0
7.6
15
17
WZC30
NOMESCO Finland
Teaching
2.3
7.5
68
312
H50.30
ICD-10 Finland
Intermittent esotropy
6.6
7.5
18
28
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
5.4
7.4
21
40
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
5.4
7.4
21
40
QBA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of trunk
81.0
7.4
8
*
A90
ICPC
Congenital anomaly NOS/multiple
81.0
7.4
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
7.4
44
161
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.8
7.4
23
49
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
7.4
123
730
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.0
7.4
42
148
A06AD11
ATC
lactulose; oral
2.7
7.4
50
196
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
7.4
169
1112
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
7.0
7.3
17
25
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
11.0
7.3
13
12
Q14.8
ICD-10 Finland
Other congenital malformations of posterior segment of eye
+∞
7.3
7
*
CJG40
NOMESCO Finland
Extraction of dislocated lens with implantation of artificial scleral fixed lens in posterior chamber and iridectomy or iridotomy
+∞
7.3
7
*
37870
ICD-8 Finland
Other diseases of eye, Subluxatio et luxatio lentis
+∞
7.3
7
*
26
HP
Aortic root """"composite graft""""
+∞
7.3
7
*
Q87.27
ICD-10 Finland
CHARGE association
+∞
7.3
7
*
H65.2
ICD-10 Finland
Chronic serous otitis media
5.3
7.3
21
41
B02AA02
ATC
tranexamic acid; systemic
2.3
7.3
67
311
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
7.3
46
174
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
16.0
7.2
11
7
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.4
7.2
40
842
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
7.2
99
547
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.7
7.2
30
85
XKC03
NOMESCO Finland
Water cystometry
5.1
7.2
21
42
Q16.1
ICD-10 Finland
Congenital absence, atresia and stricture of auditory canal (external)
30.4
7.2
9
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
30.4
7.2
9
*
P94.2
ICD-10 Finland
Congenital hypotonia
30.4
7.2
9
*
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
30.4
7.2
9
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.9
7.2
28
75
M41.4
ICD-10 Finland
Neuromuscular scoliosis
20.3
7.1
10
5
Q23.11
ICD-10 Finland
Bicuspid aortic valve
8.1
7.1
15
19
SPAT1231
SPAT
Assessment of adjustments needed in living environment
12.2
7.1
12
10
31
HP
Congenital heart failure surgery
12.2
7.1
12
10
H25.1
ICD-10 Finland
Senile nuclear cataract
2.9
7.1
42
154
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
10.2
7.1
13
13
K99
ICPC
Cardiovascular disease other
10.2
7.1
13
13
EB1MA
NOMESCO Finland
Cephalometry with X-ray
2.4
7.0
60
268
H26.4
ICD-10 Finland
After-cataract
4.6
7.0
23
52
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
7.0
196
1361
137
Kela drug reimbursment
Uraemia requiring dialysis
7.7
6.9
15
20
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.7
6.9
15
20
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
14.0
6.9
11
8
KFH10
NOMESCO Finland
Orchiopexy
11.1
6.8
12
11
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
9.5
6.8
13
14
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
9.5
6.8
13
14
SPAT1262
SPAT
Handing over of treatment supplies
2.1
6.8
75
379
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.7
6.8
28
79
NGK20
NOMESCO Finland
Epiphysiodesis of knee or lower leg
40.5
6.8
8
*
F79
ICD-10 Finland
Unspecified mental retardation
40.5
6.8
8
*
Z82.6
ICD-10 Finland
Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
40.5
6.8
8
*
I72.8
ICD-10 Finland
Aneurysm and dissection of other specified arteries
40.5
6.8
8
*
7373A
ICD-9 Finland
Curvature of spine, Kyphoscoliosis and scoliosis
40.5
6.8
8
*
NFK20
NOMESCO Finland
Epiphysiodesis of femur
16.9
6.8
10
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
6.7
63
293
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.5
6.7
30
90
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
7.3
6.7
15
21
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
22.8
6.7
9
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.3
6.7
60
274
114
Kela drug reimbursment
Glaucoma
4.0
6.6
25
65
RK110
NOMESCO Finland
NA
7.9
6.6
14
18
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.3
6.6
31
97
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
12.4
6.6
11
9
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.9
6.6
20
42
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
6.6
47
193
NF3AA
NOMESCO Finland
Femur X-ray examination
7.0
6.5
15
22
R06.0
ICD-10 Finland
Dyspnoea
1.9
6.5
94
528
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
6.3
6.5
16
26
C07AB02
ATC
metoprolol; systemic
2.3
6.5
59
273
R31
ICD-10 Finland
Unspecified haematuria
2.9
6.4
38
139
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
7.5
6.4
14
19
4364
FHL
Pharyngeal tongue plastic
70.5
6.4
7
*
Q35.3
ICD-10 Finland
Cleft soft palate
70.5
6.4
7
*
AJ2
HP
Reconstruction of the ascending aorta
70.5
6.4
7
*
I71.6
ICD-10 Finland
Thoracoabdominal aortic aneurysm, without mention of rupture
70.5
6.4
7
*
ZZG00
NOMESCO Finland
Graft of cartilage
70.5
6.4
7
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.4
6.4
51
220
WX110
NOMESCO Finland
Local anesthesy
1.6
6.4
397
3351
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
2.3
6.4
59
275
H50.31
ICD-10 Finland
Intermittent exotropia
4.5
6.4
21
48
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.3
6.4
30
94
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
6.4
46
190
E34.30
ICD-10 Finland
Short stature NOS
6.7
6.4
15
23
H66.9
ICD-10 Finland
Otitis media, unspecified
1.9
6.4
93
526
E34.31
ICD-10 Finland
Short stature, prenatal disorder
8.3
6.4
13
16
M21.7
ICD-10 Finland
Unequal limb length (acquired)
8.3
6.4
13
16
H26.2
ICD-10 Finland
Complicated cataract
8.3
6.4
13
16
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
3.1
6.3
33
112
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
9.4
6.3
12
13
RT490
NOMESCO Finland
NA
9.4
6.3
12
13
61
HP
Catheterization and pressure measurement of the left side of the heart
9.4
6.3
12
13
Q67.6
ICD-10 Finland
Pectus excavatum
18.2
6.3
9
5
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
6.3
47
197
RT290
NOMESCO Finland
NA
+∞
6.3
6
*
7844L
ICD-9 Finland
Symptoms involving head and neck, Voice disturbance[RINOPHONIA SEU RHINOLALIA]
+∞
6.3
6
*
Q87.00
ICD-10 Finland
Syndrome Treacher Collins
+∞
6.3
6
*
Q87.22
ICD-10 Finland
Nail-patella syndrome
+∞
6.3
6
*
Q71.4
ICD-10 Finland
Longitudinal reduction defect of radius
+∞
6.3
6
*
Q87.23
ICD-10 Finland
Rubinstein-Taybi syndrome
+∞
6.3
6
*
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
7.1
6.2
14
20
H05BX01
ATC
cinacalcet; oral
26.9
6.2
8
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
26.9
6.2
8
*
Q17.2
ICD-10 Finland
Microtia
26.9
6.2
8
*
N03AF02
ATC
oxcarbazepine; oral
3.2
6.2
30
96
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
12.7
6.1
10
8
SJC00
NOMESCO Finland
Bracket with fixed attachment
12.7
6.1
10
8
WX722
NOMESCO Finland
PEEP
3.2
6.1
30
98
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
8.7
6.1
12
14
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
6.8
6.1
14
21
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.8
6.1
115
707
RK320
NOMESCO Finland
NA
10.2
6.0
11
11
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
3.9
6.0
23
61
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
6.0
29
93
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
221
714
4.26
61.07
4.8
4.2
1131.4
810.9
ng/l
0.66
195
581
111
230
5.66
52.51
3.6
5.2
154.4
166.3
ng/l
0.13
104
206
189
783
3.03
32.76
11.3
10.0
1.2
1.2
mmol/l
0.39
183
750
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
59
104
6.16
32.67
7.6
23.3
0.3
0.3
u/ml
0.52
32
67
168
669
3.07
31.04
3.9
2.7
12.5
14.4
umol/l
2.81
161
630
147
569
3.08
28.30
4.2
2.8
21.4
24.0
%
1.60
134
511
336
1982
2.52
27.86
16.3
10.1
1.2
1.2
mmol/l
2.54
321
1869
296
1653
2.52
27.55
7.1
6.8
36.5
37.2
g/l
1.25
285
1565
152
611
2.97
27.27
4.0
2.7
2.4
2.4
g/l
1.27
143
579
350
2140
2.46
26.32
15.2
10.1
1.2
1.2
mmol/l
1.64
313
1905
225
1153
2.49
24.62
2.7
2.9
3.1
2.7
mg/l
0.88
200
1026
90
282
3.56
24.25
47.5
14.9
1.6
1.2
inr
0.83
11
46
56
130
4.63
22.71
1.7
2.2
1.2
1.3
g/l
0.26
45
119
154
700
2.60
21.30
7.5
8.7
0.8
0.8
mmol/l
0.16
148
668
109
417
2.96
20.99
3.6
5.8
255.0
274.6
u/l
0.47
109
405
206
1107
2.29
19.43
3.0
2.8
—
—
—
0
0
149
697
2.50
19.21
3.8
3.7
1536.3
569.9
ng/l
0.90
115
422
64
187
3.70
19.03
15.9
12.3
—
—
—
0
0
298
1875
2.14
18.77
3.8
2.9
76.2
71.8
nmol/l
2.04
280
1754
373
2577
2.13
18.12
10.3
6.1
6.1
6.4
mmol/l
2.29
359
2377
179
944
2.26
17.37
3.1
3.5
2.3
1.1
mg/l
2.01
135
710
84
308
3.00
17.31
10.2
18.2
1.4
1.1
mg/l
1.44
79
302
234
1394
2.09
16.51
5.1
3.6
500.5
49.4
e6/l
0.47
185
1056
90
355
2.79
16.20
14.5
9.7
0.2
0.8
mmol/l
0.55
77
288
430
3217
2.10
15.88
8.8
6.7
93.5
92.7
u/l
0.09
412
3047
308
2050
2.00
15.78
4.5
4.2
—
—
—
0
0
308
2050
2.00
15.78
7.4
7.2
15.9
15.9
umol/l
0.01
292
1942
251
1559
2.03
15.60
5.4
3.7
—
—
—
0
0
137
685
2.28
14.86
8.7
9.8
1.8
1.3
mmol/l
0.94
121
551
563
4784
2.98
14.36
25.1
12.5
139.4
139.6
mmol/l
1.66
555
4662
563
4792
2.96
14.16
25.6
12.6
4.0
3.9
mmol/l
4.86
555
4649
214
1301
1.98
13.77
2.0
1.7
98.2
96.5
pmol/l
0.19
116
689
402
3015
1.95
13.70
11.7
10.6
3.8
3.8
e9/l
0.06
360
2571
14
12
11.91
13.56
1.2
1.7
—
—
—
0
0
70
272
2.77
12.89
3.3
2.6
69.9
76.3
ml/min/173m2
0.48
31
106
209
1295
1.93
12.49
5.2
3.4
0.3
0.3
e6/l
0.15
167
964
34
86
4.12
12.33
4.1
4.4
12.8
9.4
%
1.09
28
75
135
724
2.10
12.08
1.7
1.4
20.9
20.0
nmol/l
0.27
121
639
113
567
2.21
11.97
8.2
9.8
23.8
23.6
mmol/l
0.34
108
543
117
597
2.18
11.88
2.5
2.0
—
—
—
0
0
204
1274
1.90
11.78
4.2
3.1
2.4
2.4
mmol/l
0.91
187
1159
32
84
3.96
11.05
4.3
4.5
—
—
—
0
0
20
37
5.55
10.45
2.5
1.7
123.7
137.4
%
0.53
20
37
115
613
2.07
10.34
13.3
9.7
1.7
1.1
mmol/l
1.35
92
454
171
1047
1.87
10.29
2.3
2.3
321.4
288.3
u/l
0.16
164
1003
32
91
3.65
9.89
2.9
2.8
134.8
132.2
g/l
0.23
24
69
52
199
2.76
9.84
1.8
1.7
—
—
—
0
0
133
761
1.95
9.77
3.7
3.3
2.3
2.2
e6/l
0.11
84
416
320
2388
1.70
9.54
4.3
3.2
126.5
83.6
ug/l
1.19
300
2257
135
788
1.91
9.31
3.7
3.1
0.9
0.7
e6/l
0.19
85
445
28
77
3.76
9.08
3.5
3.3
661.6
760.5
e6/l
—
5
17
367
2874
1.68
8.85
5.6
3.8
565.0
481.2
e6/l
0.05
12
31
89
460
2.09
8.62
1.8
1.6
1077.1
1159.0
nmol/l
0.39
71
366
227
1599
1.66
8.05
3.5
4.1
36.1
31.4
u/l
0.51
222
1532
456
3831
1.72
8.00
19.0
8.8
96.0
94.7
ml/min/173m2
0.44
378
2927
69
337
2.18
7.72
4.4
2.6
—
—
—
0
0
25
72
3.57
7.61
3.2
2.9
17.7
16.4
%
1.09
17
35
447
3759
1.68
7.55
4.7
3.7
14.8
14.4
pmol/l
2.60
426
3495
84
448
2.01
7.45
2.5
2.0
—
—
—
0
0
173
1156
1.69
7.39
3.9
2.9
24.8
43.5
ng/l
0.66
116
601
82
443
1.98
7.01
2.5
1.9
—
—
—
0
0
56
264
2.23
6.83
1.9
1.7
—
—
—
0
0
13
25
5.29
6.51
2.0
3.7
152.6
182.4
ug/l
0.17
13
25
25
80
3.21
6.50
1.5
1.5
—
—
—
0
0
497
4374
1.69
6.25
5.3
4.3
1.9
2.1
mu/l
0.35
477
4122
555
5047
1.97
6.20
21.9
11.5
28.4
21.2
mg/l
4.54
458
3677
73
399
1.94
6.03
1.9
1.8
18.4
17.4
iu/l
0.08
54
309
10
16
6.33
5.96
1.0
2.2
—
—
—
0
0
520
4656
1.73
5.85
26.6
15.0
13.7
13.3
%
4.75
511
4592
15
36
4.24
5.84
1.4
1.0
96.9
90.8
%
—
7
19
30
114
2.71
5.81
1.7
1.6
—
—
—
0
0
46
216
2.22
5.69
2.0
3.5
64.7
66.1
g/l
0.51
46
204
30
118
2.62
5.45
3.9
2.9
—
—
—
0
0
31
126
2.54
5.28
2.1
2.0
—
—
—
0
0
76
441
1.82
5.23
2.7
2.2
11.4
12.6
nmol/l
0.51
64
385
30
121
2.55
5.19
2.0
1.8
—
—
—
0
0
14
35
4.07
5.19
1.8
1.1
77.8
90.5
%
—
6
18
48
246
2.03
4.78
7.1
5.1
1.2
1.2
mmol/l
0.34
43
221
24
91
2.70
4.70
1.5
1.9
3.7
3.8
g/l
0.07
19
69
24
91
2.70
4.70
1.5
1.9
—
—
—
0
0
92
583
1.68
4.66
5.2
5.5
5.4
7.1
umol/l
1.14
73
499
175
1289
1.50
4.65
5.4
3.8
7.4
8.5
mmol/l
2.41
162
1153
16
48
3.39
4.63
1.3
2.1
—
—
—
0
0
167
1220
1.50
4.62
2.7
2.9
56.4
56.0
u/l
0.03
154
1141
59
330
1.87
4.57
2.3
2.0
5.6
7.5
u/l
1.05
34
245
12
30
4.06
4.45
1.6
1.9
20.3
16.2
nmol/l
—
6
10
95
616
1.64
4.40
1.5
1.6
435.8
27027474.5
pmol/l
0.80
78
555
127
883
1.55
4.40
6.2
4.1
16.0
28.8
mg/mmol
0.30
97
602
28
122
2.35
4.16
1.8
1.4
—
—
—
0
0
28
122
2.35
4.16
1.8
1.4
—
—
—
0
0
33
155
2.19
4.13
2.0
2.0
—
—
—
0
0
24
99
2.48
4.01
2.2
2.4
—
—
—
0
0
23
93
2.53
4.00
1.6
1.7
—
—
—
0
0
268
2186
1.40
4.00
4.9
3.2
0.0
0.0
estimate
0.00
56
407
129
919
1.51
3.97
3.3
3.3
3553.4
4096.7
umol/l
0.06
120
841
12
33
3.69
3.93
6.8
10.3
—
—
—
0
0
13
38
3.47
3.91
1.2
2.0
2.2
3.6
nmol/l
0.79
13
38
22
88
2.55
3.91
4.6
4.5
55.5
54.7
%
0.10
22
88
43
231
1.92
3.79
1.6
1.4
—
—
—
0
0
148
1094
1.46
3.78
1.6
1.8
1.7
1.4
mmol/l
1.66
135
978
82
535
1.61
3.71
2.5
2.5
2.4
2.4
mmol/l
0.29
69
459
67
424
1.65
3.43
2.8
2.6
30.5
32.5
u/l
0.24
62
357
21
88
2.43
3.42
3.8
4.1
3.3
4.0
e9/l
0.82
21
88
44
247
1.84
3.41
3.2
4.3
4.9
22.3
ug/l
0.48
28
197
18
70
2.62
3.40
1.4
1.3
—
—
—
0
0
18
70
2.62
3.40
1.7
1.7
—
—
—
0
0
68
434
1.64
3.37
1.4
1.4
242.9
262.5
u/ml
0.06
63
399
147
1108
1.43
3.36
5.2
3.4
0.0
0.0
estimate
0.45
54
413
42
234
1.85
3.34
1.7
1.4
—
—
—
0
0
19
77
2.51
3.32
1.6
1.9
37.7
39.7
g/l
0.56
19
69
33
170
1.99
3.30
7.7
6.8
48.9
54.2
%
0.52
33
170
28
535
0.50
3.29
1.4
1.5
—
—
—
0
0
409
3640
1.36
3.26
5.3
4.4
36.6
38.1
mmol/mol
3.13
389
3471
31
157
2.02
3.25
2.0
2.2
—
—
—
0
0
263
2195
1.34
3.20
6.8
4.5
0.0
0.0
estimate
0.00
56
427
544
5099
1.55
3.17
12.8
9.2
27.3
27.3
u/l
0.01
533
4955
265
2223
1.33
3.08
5.0
3.2
0.0
0.0
estimate
0.00
54
402
24
472
0.49
3.08
1.4
1.5
—
—
—
0
0
381
3375
1.33
3.01
4.8
4.0
10.9
8.6
mm/h
2.49
358
3155
15
57
2.67
2.98
3.9
5.6
2.2
2.1
ug/l
0.03
15
57
5
6
8.38
2.75
4.6
5.5
—
—
—
0
0
9
24
3.79
2.68
1.7
3.1
—
—
—
0
0
9
25
3.63
2.58
1.0
1.3
—
—
—
0
0
14
312
0.44
2.56
1.9
1.4
—
—
—
0
0
24
122
2.00
2.53
1.3
1.5
—
—
—
0
0
12
282
0.41
2.50
2.1
1.8
—
—
—
0
0
25
130
1.96
2.48
1.3
1.4
355.5
313.6
ug/g
0.56
18
66
11
252
0.43
2.18
1.5
1.4
—
—
—
0
0
11
252
0.43
2.18
1.5
1.4
—
—
—
0
0
11
252
0.43
2.18
1.5
1.4
—
—
—
0
0
11
251
0.43
2.16
1.5
1.4
—
—
—
0
0
48
705
0.65
2.14
2.0
2.0
—
—
—
0
0
12
49
2.48
2.11
1.1
1.3
—
—
—
0
0
5
10
5.03
2.07
1.0
1.1
14.6
14.7
u/l
—
5
10
13
273
0.46
2.07
1.4
1.5
—
—
—
0
0
6
15
4.03
2.04
1.0
1.3
—
—
—
0
0
8
26
3.10
2.02
2.5
2.0
—
18.2
—
0
10
20
106
1.92
1.92
5.5
5.0
431.6
392.5
umol/l
0.61
20
97
19
100
1.93
1.87
1.8
1.9
—
—
—
0
0
13
59
2.23
1.85
1.7
1.7
—
—
—
0
0
17
87
1.98
1.81
1.4
1.1
—
—
—
0
0
17
87
1.98
1.81
1.3
1.7
—
—
—
0
0
21
117
1.82
1.76
2.6
2.8
318.5
56.4
u/ml
0.63
16
100
13
61
2.15
1.72
4.5
4.5
24.8
25.5
umol/l
0.11
13
61
22
366
0.59
1.70
2.9
2.3
—
17.3
—
0
23
85
1082
0.75
1.68
2.3
2.2
—
—
—
0
0
13
62
2.12
1.66
1.4
1.5
—
—
—
0
0
13
62
2.12
1.66
1.9
1.4
—
—
—
0
0
39
565
0.67
1.66
1.8
1.9
—
—
—
0
0
10
43
2.35
1.60
4.4
5.1
—
—
—
0
0
10
43
2.35
1.60
4.4
5.1
—
—
—
0
0
10
206
0.48
1.56
1.5
1.7
—
—
—
0
0
28
177
1.61
1.54
1.3
1.5
—
405.7
—
0
7
14
256
0.54
1.53
1.2
1.4
150.8
264.9
miu/ml
—
7
131
5
15
3.35
1.52
3.2
2.3
—
—
—
0
0
96
1184
0.78
1.50
2.2
2.3
—
—
—
0
0
5
16
3.14
1.44
1.2
1.4
—
—
—
0
0
5
16
3.14
1.44
1.2
1.4
—
—
—
0
0
9
39
2.33
1.43
1.0
1.4
—
—
—
0
0
12
225
0.52
1.43
1.5
1.6
—
—
—
0
0
10
46
2.19
1.40
1.1
1.4
—
—
—
0
0
19
112
1.72
1.36
1.7
2.0
—
—
—
0
0
6
24
2.51
1.30
3.8
8.0
—
—
—
0
0
6
24
2.51
1.30
3.5
7.5
—
—
—
0
0
5
18
2.79
1.28
1.2
1.4
—
—
—
0
0
5
18
2.79
1.28
4.2
1.6
—
—
—
0
0
5
18
2.79
1.28
1.2
1.4
—
—
—
0
0
426
4011
1.20
1.28
4.0
3.3
5.7
5.7
mmol/l
0.18
400
3734
8
35
2.30
1.27
3.9
3.0
670.6
732.9
u/ml
—
8
35
51
382
1.36
1.26
3.1
3.4
31.6
31.3
%
0.06
42
275
16
92
1.76
1.26
1.8
2.0
—
—
—
0
0
6
25
2.41
1.24
4.0
2.7
720.0
631.1
ml
—
6
13
15
85
1.78
1.23
1.7
1.3
1.4
5.8
u/ml
—
8
33
15
85
1.78
1.23
1.6
1.3
4.2
4.5
u/ml
—
10
41
8
37
2.18
1.21
1.6
3.2
2.4
3.1
nmol/l
—
8
37
21
132
1.61
1.21
1.2
1.4
0.5
0.4
nmol/l
0.29
16
107
185
1630
1.19
1.19
5.2
3.1
—
—
—
0
0
8
39
2.06
1.15
1.5
1.2
69.8
76.0
%
—
8
39
8
39
2.06
1.15
1.5
1.3
—
—
—
0
0
7
30
2.35
1.12
2.1
2.0
—
—
—
0
0
7
31
2.27
1.10
1.3
1.3
—
—
—
0
0
8
41
1.96
1.09
1.4
1.6
—
—
—
0
0
8
41
1.96
1.09
1.4
1.6
—
—
—
0
0
8
41
1.96
1.09
1.4
1.6
—
—
—
0
0
9
46
1.97
1.04
7.2
4.3
22.2
27.4
ug/l
—
9
46
13
75
1.75
1.03
1.5
1.8
—
—
—
0
0
528
5113
1.22
0.97
26.1
13.4
39.3
40.3
%
3.84
435
4345
13
77
1.70
0.95
1.0
1.0
1.5
1.4
g/l
0.45
13
70
24
166
1.46
0.95
1.2
1.1
—
—
—
0
0
160
1792
0.85
0.95
1.9
1.8
—
—
—
0
0
442
4227
1.16
0.90
4.4
3.7
2.8
2.8
mmol/l
0.60
424
3994
32
238
1.36
0.87
2.1
1.9
299.1
184.5
u/ml
0.90
20
125
12
72
1.68
0.85
1.8
1.5
—
—
—
0
0
6
32
1.88
0.82
1.0
1.0
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
19
131
1.46
0.79
1.9
1.7
189.0
222.5
pmol/l
0.57
19
126
8
48
1.67
0.79
1.0
1.0
—
—
—
0
0
23
165
1.41
0.78
1.2
1.1
—
—
—
0
0
26
191
1.38
0.78
2.0
1.6
37.7
37.3
nmol/l
0.02
26
186
46
369
1.27
0.76
3.0
2.5
11006.5
3953.4
u/l
0.43
15
152
439
4218
1.14
0.75
4.2
3.6
4.5
4.6
mmol/l
3.08
421
4020
343
3247
1.13
0.75
3.8
3.7
49.6
37.9
u/l
1.73
325
3129
11
172
0.63
0.75
1.3
1.5
—
—
—
0
0
421
4037
1.13
0.74
3.8
3.2
1.3
1.2
mmol/l
1.32
402
3826
435
4180
1.14
0.74
4.1
3.5
1.3
1.4
mmol/l
9.29
417
3964
20
142
1.42
0.73
2.5
1.9
4.1
5.5
iu/l
—
9
52
9
56
1.61
0.72
1.3
1.3
—
—
—
0
0
5
26
1.93
0.70
1.0
1.6
1.0
1.0
g/l
—
5
26
9
142
0.63
0.70
1.2
2.2
0.7
0.6
nmol/l
—
9
121
14
93
1.52
0.70
1.5
1.7
—
—
—
0
0
31
242
1.29
0.65
2.0
1.9
—
—
—
0
0
5
29
1.73
0.64
6.6
3.1
—
—
—
0
0
8
49
1.64
0.62
1.3
1.3
260.8
543.7
pmol/l
—
8
42
0
20
0.00
0.60
0.0
1.1
—
20.6
—
0
10
0
21
0.00
0.60
0.0
1.0
—
3.7
—
0
12
110
985
1.14
0.59
4.6
3.2
1.0
1.0
kg/l
1.58
26
150
7
115
0.60
0.58
1.3
1.6
—
—
—
0
0
50
421
1.20
0.57
1.5
1.3
203.8
165.8
iu/ml
0.16
14
156
6
36
1.67
0.56
1.3
1.2
356.2
182.0
iu/ml
—
6
36
6
36
1.67
0.56
1.0
1.1
—
—
—
0
0
5
87
0.57
0.56
1.0
1.8
—
—
—
0
0
6
38
1.58
0.54
1.3
1.6
—
—
—
0
0
62
708
0.86
0.50
1.5
1.2
15.4
7.2
u/ml
0.33
24
275
7
45
1.56
0.49
1.0
1.4
—
—
—
0
0
7
47
1.49
0.47
1.1
1.1
—
—
—
0
0
18
231
0.77
0.45
1.4
1.3
—
—
—
0
0
14
103
1.37
0.45
1.1
1.2
—
19.1
—
0
7
441
4519
0.91
0.45
3.7
3.8
—
—
—
0
0
24
296
0.80
0.45
1.1
1.2
3.5
2.4
u/ml
0.24
16
173
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
1.8
—
0
9
0
17
0.00
0.40
0.0
1.0
—
10.3
—
0
10
177
1665
1.09
0.40
1.4
1.6
1.7
2.3
u/ml
0.18
45
372
17
132
1.30
0.40
1.4
1.2
—
—
—
0
0
8
61
1.31
0.39
1.0
1.0
—
—
—
0
0
10
71
1.41
0.39
1.1
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
13
98
1.33
0.37
1.0
1.2
—
—
—
0
0
13
98
1.33
0.37
1.0
1.2
—
1.3
—
0
5
12
155
0.77
0.33
1.0
1.1
—
—
—
0
0
25
292
0.85
0.30
1.6
1.6
—
—
—
0
0
13
163
0.79
0.30
1.1
1.1
4.2
0.5
u/ml
—
6
60
22
258
0.85
0.28
1.6
1.8
—
—
—
0
0
8
63
1.27
0.28
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
1.2
1.2
13.6
3.6
u/ml
—
5
36
0
11
0.00
0.21
0.0
1.0
—
650.8
—
0
6
0
11
0.00
0.21
0.0
1.1
—
31.8
—
0
6
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
6
50
1.20
0.19
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.5
1.5
—
—
—
0
0
6
51
1.18
0.19
1.5
1.5
—
—
—
0
0
40
368
1.09
0.17
6.5
5.7
—
—
—
0
0
7
62
1.13
0.17
1.0
1.1
—
—
—
0
0
5
66
0.76
0.17
1.0
1.3
—
353.0
—
0
10
12
141
0.85
0.16
1.1
4.1
3.5
3.4
mmol/l
0.29
12
134
8
70
1.14
0.16
2.1
1.8
—
—
—
0
0
9
81
1.11
0.15
1.3
1.2
—
—
—
0
0
17
150
1.14
0.14
1.1
1.6
—
—
—
0
0
60
631
0.94
0.13
3.1
3.4
24.5
21.4
%
0.37
16
232
11
94
1.17
0.13
1.4
1.4
—
—
—
0
0
14
157
0.89
0.11
1.1
1.9
—
—
—
0
0
10
115
0.87
0.11
1.1
1.2
—
—
—
0
0
12
135
0.89
0.10
1.0
1.9
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
83
803
1.04
0.09
3.2
3.7
1.5
1.6
ug/l
0.11
78
727
5
48
1.04
0.09
1.0
1.0
—
—
—
0
0
50
478
1.05
0.09
1.1
1.1
—
—
—
0
0
18
165
1.09
0.08
1.6
1.6
0.0
0.0
iu/ml
—
6
39
7
66
1.06
0.08
1.1
1.1
—
—
—
0
0
44
458
0.96
0.07
2.1
2.5
0.7
0.7
ug/l
0.10
28
244
24
255
0.94
0.07
1.0
1.2
—
—
—
0
0
79
807
0.98
0.05
1.3
1.5
—
—
—
0
0
25
242
1.03
0.02
1.2
1.3
—
—
—
0
0
10
98
1.02
0.00
6.7
3.4
78.9
3.5
u/ml
—
10
90
15
151
0.99
0.00
1.1
4.0
279.3
403.4
mg/l
1.67
15
146
37
367
1.01
0.00
1.3
1.3
—
—
—
0
0
74
743
0.99
0.00
1.4
1.3
40.7
25.5
iu/ml
0.21
21
215
17
170
1.00
0.00
1.5
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.6
1.5
—
—
—
0
0
5
54
0.92
0.00
1.0
1.2
—
—
—
0
0
5
55
0.91
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
5.0
—
3.6
—
0
8
5
54
0.92
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS | 4.369 [3.04, 6.28] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.176 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 2512 females with Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS | 4.099 [3.26, 5.16] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 2556 males with Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.44% | 0.835% |
| 5 | 2.571% | 4.97% |
| 10 | 6.367% | 12.307% |
| 15 | 11.887% | 21.957% |
| 20 | 20.333% | 34.286% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_SPECIFE_CONGEN_MALFO_SYNDR_AFFECTING_MULTIPLE_SYSTEMS – Other specified congenital malformation syndromes affecting multiple systems
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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