Toxic effect of alcohol

ST19_TOXIC_EFFECT_ALCOHOL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 T51
  • Hospital discharge: ICD-9 980
  • Hospital discharge: ICD-8 980
  • Hospital discharge: excluded ICD-10 T51.0
  • Hospital discharge: excluded ICD-9 9800
  • Cause of death: ICD-10 T51
  • Cause of death: ICD-9 980
  • Cause of death: ICD-8 980
  • Cause of death: excluded ICD-10 T51.0
  • Cause of death: excluded ICD-9 9800

2 out of 7 registries used, show all original rules.

817

4. Check minimum number of events

None

817

5. Include endpoints

None

817

6. Filter based on genotype QC (FinnGen only)

817

Control definitions (FinnGen only)

Control exclude
ST19_TOXIC_EFFEC_SUBST_CHIEF_NONME_SOURCE

Extra metadata

Level in the ICD hierarchy
3
Special
ALCOTOXIC
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T51-T65
Name in latin
Effectus alcoholicus toxicus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10946 3014 7772
Only index persons 7769 2497 5272
Unadjusted period prevalence (%)
Whole population 0.18 0.09 0.22
Only index persons 0.17 0.09 0.20
Median age at first event (years)
Whole population 28.20 21.94 30.22
Only index persons 22.55 19.17 24.15

-FinnGen-

Key figures

All Female Male
Number of individuals 817 302 515
Unadjusted period prevalence (%) 0.18 0.10 0.23
Median age at first event (years) 25.36 20.34 28.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
755
Matched controls
7550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
98000
ICD-8 Finland
Toxic effect of alcohol, Ethyl alcohol
+∞
323.0
396
*
T51.9
ICD-10 Finland
Toxic effect: Alcohol, unspecified
+∞
147.9
137
*
E8699
ICD-8 Finland
Accidental poisoning by other and unspecified solid and liquid substances
199.3
116.1
118
7
X45
ICD-10 Finland
Accidental poisoning by and exposure to alcohol
232.7
100.1
101
5
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.7
93.8
208
284
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
18.2
85.1
136
90
T36
ICD-10 Finland
Poisoning by systemic antibiotics
12.5
73.0
137
131
T51.0
ICD-10 Finland
Toxic effect: Ethanol
+∞
68.8
65
*
98099
ICD-8 Finland
Toxic effect of alcohol, Other
+∞
60.2
57
*
E9509
ICD-8 Finland
Suicide and self-inflicted poisoning by solid or liquid substances, Other and unspecified solid and liquid substances
49.8
53.2
64
14
T51.1
ICD-10 Finland
Toxic effect: Methanol
+∞
52.7
50
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
18.8
52.0
81
48
T51.8
ICD-10 Finland
Toxic effect: Other alcohols
+∞
51.7
49
*
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
11.6
46.0
88
85
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
29.8
43.2
58
21
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
14.0
42.5
74
58
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
32.8
42.0
55
18
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
36.3
39.9
51
15
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
18.5
33.7
52
30
F10.20
ICD-10 Finland
Alcohol dependence currently independent
10.7
33.0
65
66
30310
ICD-8 Finland
Alcoholism, Habitual excessive drinking
29.1
32.8
44
16
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.9
32.5
148
442
N05AA02
ATC
levomepromazine; systemic
6.7
32.1
85
140
N07BB01
ATC
disulfiram; oral
5.5
31.9
99
200
F10.09
ICD-10 Finland
Alcohol intoxication UNS
9.5
31.6
66
75
N05BA01
ATC
diazepam; systemic, rectal
3.5
29.5
158
533
E9809
ICD-8 Finland
Poisoning by solid or liquid substances, undetermined whether accidentally or purposely inflicted, Other and unspecified solid and liquid substances
68.8
29.1
33
5
N05BA02
ATC
chlordiazepoxide; systemic
9.5
28.7
60
68
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
10.7
28.7
56
56
N05AH04
ATC
quetiapine; oral
3.0
27.5
180
704
F10.24
ICD-10 Finland
Alcohol depence active use
11.3
26.4
50
47
N05BA04
ATC
oxazepam; oral
2.7
26.0
219
999
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.1
25.1
105
287
N05CD07
ATC
temazepam; oral
3.5
25.1
127
409
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
17.1
24.7
39
24
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
11.6
24.7
46
42
F10.25
ICD-10 Finland
Alcohol dependence continuous use
8.6
24.6
54
67
N06AX11
ATC
mirtazapine; oral
2.4
24.2
277
1479
P15
ICPC
Chronic alcohol abuse
6.2
23.8
66
115
T51.2
ICD-10 Finland
Toxic effect: 2-Propanol
+∞
23.0
22
*
V03AA01
ATC
NA
10.8
22.9
44
43
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
11.7
22.2
41
37
N05CF01
ATC
zopiclone; oral
2.3
21.2
260
1417
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
11.7
20.7
38
34
N06AB04
ATC
citalopram; systemic
2.5
20.1
186
876
P16
ICPC
Acute alcohol abuse
7.7
19.7
46
63
N05AB01
ATC
dixyrazine; systemic
12.7
19.2
34
28
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
11.8
18.6
34
30
30399
ICD-8 Finland
Other and unspecified alcoholism
33.8
18.0
23
7
B18.2
ICD-10 Finland
Chronic viral hepatitis C
14.1
17.9
30
22
9809X
ICD-9 Finland
Toxic effect of alcohol, Unspecified alcohol
+∞
17.8
17
*
N03AG01
ATC
valproic acid; systemic, rectal
3.7
17.3
78
227
R40.2
ICD-10 Finland
Coma, unspecified
16.4
17.1
27
17
30180
ICD-8 Finland
Personality disorders, Immatura
17.9
17.0
26
15
S06.0
ICD-10 Finland
Concussion
3.0
17.0
102
368
N05BE01
ATC
buspirone; oral
6.3
16.6
44
73
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
9.3
16.6
34
38
E970A
ICD-9 Finland
Injury due to legal intervention by firearms
173.7
16.6
17
*
N05AF03
ATC
chlorprothixene; systemic
6.1
16.4
45
78
N06AB03
ATC
fluoxetine; oral
2.8
16.3
116
466
E9599
ICD-8 Finland
Late effect of self-inflicted injury
61.4
15.8
18
*
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
11.1
15.6
29
27
Y91.1
ICD-10 Finland
Moderate alcohol intoxication
163.2
15.5
16
*
N05AH03
ATC
olanzapine; systemic
3.5
15.4
74
227
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.2
15.1
82
276
9800A
ICD-9 Finland
Toxic effect of alcohol, Ethyl alcohol
57.9
14.8
17
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
8.0
14.7
33
43
N05AD01
ATC
haloperidol; systemic
5.7
14.7
42
77
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.8
14.7
63
176
Y91.2
ICD-10 Finland
Severe alcohol intoxication
+∞
14.6
14
*
T65.9
ICD-10 Finland
Toxic effect: Toxic effect of unspecified substance
+∞
14.6
14
*
Y19
ICD-10 Finland
Poisoning by and exposure to other and unspecified chemicals and noxious substances, undetermined intent
36.8
14.5
18
5
K92.0
ICD-10 Finland
Haematemesis
5.9
14.4
40
71
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
14.3
219
1270
30188
ICD-8 Finland
Personality disorders, Alia definita
27.8
14.3
19
7
N05AH02
ATC
clozapine; systemic
6.5
14.0
36
58
E8599
ICD-8 Finland
Accidental poisoning by other and unspecified drugs and medicaments, Drugs, unspecified
24.3
13.8
19
8
AA1AD
NOMESCO Finland
CT of head and brain
2.1
13.7
177
956
F61.0
ICD-10 Finland
Mixed personality disorders
8.2
13.7
30
38
5353A
ICD-9 Finland
Gastritis and duodenitis, Alcoholic gastritis
+∞
13.6
13
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
8.5
13.1
28
34
N06AX03
ATC
mianserin; oral
4.2
13.1
50
126
E850A
ICD-9 Finland
Accidental poisoning by analgesics, antipyretics, antirheumatics
50.9
12.9
15
*
85000
ICD-8 Finland
Concussion, Current or unspecified
5.4
12.7
38
74
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
7.2
12.7
30
43
30041
ICD-8 Finland
Neuroses, Depressiva
7.6
12.3
28
38
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.9
12.1
76
282
Z72.1
ICD-10 Finland
Alcohol use
7.4
12.1
28
39
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
11.9
110
509
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.9
11.8
38
81
C07AA05
ATC
propranolol; systemic
2.1
11.7
143
751
N05AX08
ATC
risperidone; systemic
3.0
11.7
68
240
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
8.3
11.6
25
31
F10.07
ICD-10 Finland
Pathological alcohol intoxication
66.0
11.6
13
*
96798
ICD-8 Finland
Other sleeping pills and sedatives
66.0
11.6
13
*
N06AA12
ATC
doxepin; systemic
3.5
11.5
54
163
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
11.4
122
602
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
15.3
11.3
18
12
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
11.2
129
659
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
11.4
11.1
20
18
N05AD03
ATC
melperone; systemic
8.7
11.1
23
27
N05AB03
ATC
perphenazine; systemic, rectal
4.0
11.1
44
116
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
10.9
66
238
N05CD02
ATC
nitrazepam; oral
8.4
10.9
23
28
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
4.6
10.9
37
84
30000
ICD-8 Finland
Neuroses, Anxiety neurosis
11.4
10.6
19
17
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.9
10.5
42
111
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
14.5
10.5
17
12
98020
ICD-8 Finland
Toxic effect of alcohol, Isopropyl alcohol
+∞
10.4
10
*
N04AA02
ATC
biperiden; systemic
5.6
10.4
29
53
2918A
ICD-9 Finland
Alcoholic psychoses, Other specified alcoholic psychosis
33.0
10.4
13
*
2910A
ICD-9 Finland
Alcoholic psychoses, Alcohol withdrawal delirium
33.0
10.4
13
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
9.3
10.1
20
22
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
10.2
10.1
19
19
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
10.0
147
827
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
40.6
10.0
12
*
N06AB06
ATC
sertraline; oral
2.3
9.9
94
438
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.8
9.9
41
113
97010
ICD-8 Finland
Adverse effect of psychotherapeutics, Tranquillisers
26.4
9.8
13
5
N06AX16
ATC
venlafaxine; oral
2.1
9.8
111
561
29120
ICD-8 Finland
Alcoholic psychosis, Other alcoholic hallucinosis
55.7
9.7
11
*
9694A
ICD-9 Finland
Poisoning by psychotropic agents, Benzodiazepine-based tranquillisers
15.3
9.5
15
10
N06AB10
ATC
escitalopram; oral
1.9
9.5
152
881
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
9.5
170
1027
N05BA12
ATC
alprazolam; oral
2.4
9.4
84
380
Y91.0
ICD-10 Finland
Mild alcohol intoxication
101.2
9.4
10
*
F60.2
ICD-10 Finland
Dissocial personality disorder
17.8
9.4
14
8
A06AD11
ATC
lactulose; oral
2.1
9.4
107
544
30040
ICD-8 Finland
Neuroses, Neurotico-depressiva
12.5
9.4
16
13
E9609
ICD-8 Finland
Fight, brawl, rape
10.8
9.3
17
16
N06AB05
ATC
paroxetine; oral
2.9
9.2
57
209
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
13.9
9.2
15
11
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.0
9.1
24
41
P99
ICPC
Psychological disorders other
4.4
9.1
32
76
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
9.2
9.1
18
20
97940
ICD-8 Finland
Alcohol in combination with specified medicinal agents, With psychopharmacological agents
37.2
9.0
11
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
8.8
69
293
SPAT1265
SPAT
Breathalyser
6.7
8.7
21
32
P29
ICPC
Psychological sympt/compl other
2.8
8.7
55
207
E8859
ICD-8 Finland
Fall on same level from slipping, stumbling or tripping
3.1
8.6
45
149
N05AX12
ATC
aripiprazole; systemic
3.3
8.6
42
133
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
16.5
8.6
13
8
P01
ICPC
Feeling anxious/nervous/tense
2.4
8.5
75
337
N02AX02
ATC
tramadol; systemic, rectal
1.6
8.4
294
2149
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.4
8.4
29
68
N03AX09
ATC
lamotrigine; oral
3.1
8.4
44
147
79301
ICD-8 Finland
Observation, without need for further medical care, Observatio post tentationem suicidii
+∞
8.3
8
*
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
8.7
8.3
17
20
P18
ICPC
Medication abuse
14.7
8.2
13
9
N05AC02
ATC
thioridazine; oral
4.9
8.1
25
52
29100
ICD-8 Finland
Alcoholic psychosis, Delirium tremens
33.7
8.1
10
*
92000
ICD-8 Finland
Contusion of face, scalp and neck except eye(s), Current injury
9.1
8.1
16
18
F10.05
ICD-10 Finland
Alcohol-related acute intoxication with coma
22.3
8.0
11
5
30199
ICD-8 Finland
Personality disorders, Unspecified
22.3
8.0
11
5
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
5.5
7.9
22
41
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
10.9
7.8
14
13
V03AB30
ATC
NA
9.5
7.8
15
16
X84
ICD-10 Finland
Intentional self-harm by unspecified means
45.4
7.7
9
*
W19
ICD-10 Finland
Unspecified fall
2.3
7.7
73
341
N07BA03
ATC
varenicline; oral
2.8
7.7
49
185
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
7.7
44
155
X78
ICD-10 Finland
Intentional self-harm by sharp object
12.0
7.6
13
11
F10.01
ICD-10 Finland
Alcohol-related acute intoxication with permanent or other somatic damage
12.0
7.6
13
11
S01.0
ICD-10 Finland
Open wound of scalp
2.4
7.6
62
270
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
6.3
7.6
19
31
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.9
7.6
44
157
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.7
7.4
31
87
WX730
NOMESCO Finland
Conventional respirator
4.6
7.4
24
53
K70.1
ICD-10 Finland
Alcoholic hepatitis
7.8
7.4
16
21
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
7.3
68
315
T51
ICD-10 Finland
Toxic effect of alcohol
+∞
7.3
7
*
3017A
ICD-9 Finland
Personality disorders, Antisocial personality disorder
+∞
7.3
7
*
98098
ICD-8 Finland
Toxic effect of alcohol, Other alcohols
+∞
7.3
7
*
30799
ICD-8 Finland
Transient situational disturbances
15.9
7.2
11
7
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.2
7.1
74
361
N03AF01
ATC
carbamazepine; oral, rectal
2.8
7.1
45
168
N03AE01
ATC
clonazepam; systemic
2.7
7.1
46
176
TKC20
NOMESCO Finland
Catheterisation of bladder
2.5
7.1
55
232
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.1
6.9
25
62
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.0
6.9
26
67
Y07
ICD-10 Finland
Other maltreatment
7.6
6.9
15
20
K29.2
ICD-10 Finland
Alcoholic gastritis
13.9
6.9
11
8
30088
ICD-8 Finland
Neuroses, Other
13.9
6.9
11
8
N05AA01
ATC
chlorpromazine; systemic, rectal
5.1
6.8
20
40
N05AN01
ATC
lithium; oral
3.8
6.8
27
73
R51.80
ICD-10 Finland
Headache
1.9
6.8
101
567
EBA00
NOMESCO Finland
Extraction of tooth
1.6
6.8
228
1632
Z72.2
ICD-10 Finland
Drug use
16.9
6.8
10
6
97920
ICD-8 Finland
Alcohol in combination with specified medicinal agents, With nonbarbiturate sedatives
22.7
6.7
9
*
Y90.8
ICD-10 Finland
Blood alcohol level of 240 mg/100 ml or more
22.7
6.7
9
*
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
22.7
6.7
9
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.7
6.7
43
164
C03CA01
ATC
furosemide; systemic
1.7
6.7
162
1065
SPAT1307
SPAT
Psychosocial counselling and guidance
2.7
6.6
44
172
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
6.6
274
2055
SPAT1227
SPAT
Substance abuse rehabilitation
8.2
6.3
13
16
F10.02
ICD-10 Finland
Alcohol-related acute intoxication with other acute clinical complications
11.1
6.3
11
10
E87.2
ICD-10 Finland
Acidosis
9.4
6.3
12
13
9802A
ICD-9 Finland
Toxic effect of alcohol, Isopropyl alcohol
+∞
6.3
6
*
X65
ICD-10 Finland
Intentional self-poisoning by and exposure to alcohol
+∞
6.3
6
*
T58
ICD-10 Finland
Toxic effect of carbon monoxide
+∞
6.3
6
*
97799
ICD-8 Finland
Adverse effect of other and unspecified drugs, Drugs, unspecified
+∞
6.3
6
*
30430
ICD-8 Finland
Drug dependence, Other hypnotics and sedatives or tranquillisers
26.9
6.2
8
*
F34.1
ICD-10 Finland
Dysthymia
3.4
6.2
28
85
A98
ICPC
Health maint/preventive medicine
0.6
6.2
602
6539
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
6.2
108
642
F99
ICD-10 Finland
Mental disorder, not otherwise specified
4.3
6.2
21
50
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
6.2
116
704
9690A
ICD-9 Finland
Poisoning by psychotropic agents, Antidepressants
12.6
6.1
10
8
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
8.7
6.1
12
14
S01.7
ICD-10 Finland
Multiple open wounds of head
10.1
6.0
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
56
10.87
51.60
3.7
1.4
2.0
1.1
promille
2.26
45
45
25
21
12.25
24.82
4.4
1.9
79.4
90.7
umol/l
0.12
11
12
56
121
4.90
24.64
5.3
2.3
—
—
—
0
0
67
185
3.86
21.47
8.4
2.8
—
—
—
0
0
130
535
2.70
21.43
6.7
3.8
1.3
1.9
mmol/l
0.73
107
427
72
216
3.56
20.43
4.8
1.9
—
—
—
0
0
120
502
2.63
19.05
13.1
9.3
—
—
—
0
0
77
254
3.24
18.81
4.4
2.0
—
—
—
0
0
25
33
7.78
17.90
3.7
1.5
—
—
—
0
0
78
278
3.00
16.69
4.4
2.0
—
—
—
0
0
143
689
2.30
16.59
9.9
9.1
1.0
1.1
mmol/l
0.12
115
541
78
282
2.95
16.27
4.5
2.0
—
—
—
0
0
76
281
2.88
15.21
4.5
1.9
—
—
—
0
0
30
61
5.07
14.14
25.5
15.6
1351.2
1437.3
nmol/l
0.22
30
61
145
753
2.13
13.84
11.3
7.4
104.1
104.1
mmol/l
0.02
139
737
119
582
2.22
13.18
11.2
9.9
123.2
122.9
g/l
0.06
119
561
72
280
2.72
13.10
4.7
1.8
—
—
—
0
0
261
1688
1.80
12.93
4.9
4.4
—
—
—
0
0
38
105
3.75
12.17
4.1
5.5
437.1
358.3
umol/l
2.06
31
92
68
273
2.63
11.62
7.4
3.9
23.3
24.2
mmol/l
1.03
60
252
287
1975
1.70
11.09
4.2
2.6
55.9
57.5
u/l
0.28
272
1853
423
3256
1.62
10.30
7.4
6.6
10.9
11.5
umol/l
0.66
402
3092
269
1873
1.65
9.68
2.9
2.1
354.3
295.5
u/l
0.25
264
1779
72
338
2.24
8.76
13.6
12.0
—
—
—
0
0
80
395
2.14
8.59
6.2
6.3
—
—
—
0
0
224
1532
1.64
8.47
3.7
2.7
—
—
—
0
0
158
1003
1.71
7.88
4.3
3.8
0.8
0.8
mmol/l
4.95
149
948
221
1545
1.59
7.51
8.4
6.8
—
—
—
0
0
53
234
2.35
7.45
11.2
4.7
—
—
—
0
0
42
172
2.52
6.95
5.6
4.2
3.8
3.9
mmol/l
1.09
36
160
339
2637
1.49
6.93
11.7
6.3
1.2
1.2
mmol/l
3.35
323
2420
100
578
1.83
6.84
4.9
2.5
82.9
123.9
u/l
0.17
85
497
34
126
2.77
6.84
3.7
2.8
—
—
—
0
0
47
206
2.36
6.73
7.0
4.3
1.5
1.3
mmol/l
0.44
47
200
364
2914
1.45
6.23
10.0
7.1
1.2
1.2
mmol/l
2.97
328
2473
597
6560
0.67
5.89
4.7
4.2
4.6
4.7
mmol/l
1.83
557
6165
194
1384
1.53
5.86
4.1
3.1
—
—
—
0
0
443
3705
1.43
5.83
8.6
5.0
7.1
6.7
mmol/l
2.92
428
3452
202
2699
0.67
5.81
2.8
2.6
—
—
—
0
0
594
6529
0.67
5.80
4.5
4.2
1.4
1.4
mmol/l
0.97
553
6103
87
508
1.80
5.76
3.1
2.3
4.7
8.9
ug/l
3.46
79
460
168
1168
1.55
5.69
5.2
3.8
316.1
427.1
ng/l
0.26
127
889
571
6312
0.68
5.58
4.2
3.8
1.5
1.4
mmol/l
1.82
529
5881
233
1743
1.47
5.55
6.6
4.0
7.4
7.4
ph
0.00
35
334
310
2460
1.42
5.34
8.0
8.3
1.1
1.2
inr
2.09
83
727
251
1928
1.44
5.14
2.7
2.4
—
—
—
0
0
188
1367
1.49
5.12
5.3
3.3
1.0
1.0
kg/l
0.97
20
187
135
921
1.56
4.94
2.5
2.1
—
—
—
0
0
5
239
0.20
4.91
1.2
1.6
—
—
—
0
0
614
6657
0.69
4.85
5.0
4.6
2.7
2.8
mmol/l
1.41
570
6215
547
4840
1.39
4.67
9.2
7.7
79.5
77.5
u/l
0.41
532
4574
699
7378
0.64
4.63
30.7
19.3
254.1
247.8
e9/l
1.57
687
7205
700
7386
0.64
4.62
30.8
19.4
136.6
138.7
g/l
3.10
695
7289
700
7385
0.64
4.60
30.8
19.4
7.4
6.7
e9/l
6.44
685
7198
198
1483
1.44
4.58
2.6
2.3
—
—
—
0
0
700
7383
0.64
4.55
30.6
19.3
4.5
4.6
e12/l
2.61
684
7199
171
1248
1.47
4.53
2.9
2.4
5.5
5.2
e6/l
0.10
153
1097
700
7382
0.64
4.52
30.5
19.2
30.4
30.4
pg
0.02
695
7287
700
7381
0.64
4.50
30.5
19.3
91.0
90.8
fl
0.47
695
7287
122
1729
0.65
4.48
2.5
2.7
0.6
0.7
ug/l
0.79
86
1037
67
391
1.78
4.48
5.3
4.4
129.4
86.6
ng/l
0.91
58
349
214
1638
1.42
4.37
3.7
2.9
—
—
—
0
0
238
1858
1.40
4.34
3.8
3.1
50.9
99.6
e6/l
0.62
184
1433
41
206
2.04
4.29
1.8
2.2
18059.6
3048.7
u/l
—
7
85
79
490
1.68
4.26
4.5
3.3
—
—
—
0
0
26
108
2.45
4.26
3.0
2.3
—
—
—
0
0
309
2524
1.36
4.24
6.6
5.2
34.9
36.0
g/l
2.44
288
2379
249
1967
1.38
4.21
4.8
3.2
7.7
8.3
mmol/l
0.98
216
1671
111
751
1.55
4.21
2.0
1.7
—
—
—
0
0
206
1584
1.40
4.07
6.9
3.9
89.6
91.0
%
0.34
200
1556
7
7
10.07
4.01
2.9
1.1
—
—
—
0
0
39
198
2.02
3.99
7.2
8.9
1.8
1.2
mmol/l
1.32
39
175
420
3624
1.33
3.88
13.3
9.5
4.5
4.1
e9/l
3.08
374
3193
585
6331
0.73
3.78
4.8
4.2
6.2
6.0
mmol/l
3.64
541
5840
214
1683
1.37
3.65
3.8
3.0
0.5
0.5
e6/l
0.02
165
1261
263
2141
1.34
3.57
4.7
3.6
40.0
81.0
e6/l
1.21
192
1536
45
251
1.84
3.53
6.2
7.4
0.8
0.9
%
0.78
45
236
112
791
1.48
3.48
1.9
1.6
—
—
—
0
0
34
174
2.00
3.43
3.6
3.3
—
—
—
0
0
45
254
1.82
3.40
6.3
7.3
2.4
1.6
%
2.05
45
238
241
2920
0.75
3.37
3.7
4.2
2.1
2.1
ug/l
0.02
216
2655
29
141
2.10
3.35
3.3
3.4
—
—
—
0
0
6
7
8.62
3.26
3.5
1.1
—
—
—
0
0
11
33
3.37
3.20
2.3
3.5
—
—
—
0
0
30
152
2.01
3.13
1.6
1.3
—
—
—
0
0
154
1176
1.38
3.12
3.2
2.7
515.0
569.6
mosm/kgh2o
2.05
129
1009
29
146
2.02
3.08
8.4
10.4
12.9
11.4
mmol/l
0.75
29
133
29
146
2.02
3.08
8.4
10.4
103.9
105.5
mmol/l
0.80
29
133
206
1655
1.33
3.00
4.4
3.4
0.0
0.0
estimate
1.08
55
581
361
3125
1.28
2.99
3.9
3.3
0.0
0.0
estimate
0.50
52
561
156
1203
1.37
2.97
1.6
1.7
430.1
37341570.4
pmol/l
1.43
134
1023
134
1016
1.38
2.83
1.9
1.6
—
—
—
0
0
355
3083
1.27
2.81
4.0
3.2
0.0
0.0
estimate
0.00
56
587
355
3089
1.26
2.75
5.1
4.4
0.0
0.0
estimate
0.50
60
604
159
1248
1.34
2.70
2.2
1.8
—
—
—
0
0
9
24
3.78
2.67
4.2
2.9
—
—
—
0
0
112
833
1.40
2.66
3.3
2.5
2.3
2.3
g/l
0.36
102
778
91
654
1.44
2.61
1.8
2.6
1.9
1.8
%
0.24
82
596
105
777
1.40
2.57
3.4
2.6
21.3
24.3
%
1.44
93
680
166
1323
1.32
2.53
1.6
1.5
18.5
20.2
nmol/l
0.92
147
1140
100
736
1.41
2.52
12.4
21.2
1.1
1.3
inr
1.66
17
97
9
27
3.36
2.39
3.9
5.2
—
—
—
0
0
439
3958
1.24
2.35
5.5
3.9
181.1
2004.9
e6/l
—
9
62
31
177
1.78
2.33
1.2
1.2
—
—
—
0
0
24
126
1.93
2.33
1.3
1.2
—
—
—
0
0
369
3270
1.23
2.31
6.9
6.1
2.2
2.0
e9/l
0.33
337
2908
18
85
2.14
2.30
4.4
6.5
11.1
10.5
mg/l
0.24
13
78
271
2328
1.25
2.25
2.1
1.9
90.2
95.3
pmol/l
1.17
146
1274
30
500
0.58
2.23
1.2
1.4
—
—
—
0
0
14
60
2.36
2.22
1.6
1.7
—
—
—
0
0
40
250
1.63
2.20
1.9
2.3
20.0
21.7
s
1.43
33
222
358
3176
1.23
2.19
7.0
6.0
0.6
0.6
e9/l
2.18
319
2770
359
3189
1.22
2.16
7.0
6.0
0.0
0.0
e9/l
0.66
319
2783
369
3291
1.22
2.12
8.4
6.4
0.2
0.2
e9/l
0.01
331
2927
127
1000
1.32
2.11
1.7
1.7
1207.1
1153.2
nmol/l
0.31
98
789
12
49
2.47
2.11
2.8
1.7
11.2
11.5
%
0.08
12
49
0
58
0.00
2.04
0.0
1.8
—
40.0
—
0
7
67
479
1.43
2.02
2.1
2.8
81.6
71.7
e9/l
1.43
51
371
18
91
2.00
1.96
1.4
2.8
—
—
—
0
0
12
51
2.37
1.95
5.3
4.4
—
—
—
0
0
25
145
1.75
1.83
1.4
1.2
366.6
280.8
u/ml
0.75
20
91
8
29
2.78
1.79
2.6
1.6
—
—
—
0
0
31
194
1.62
1.74
1.4
1.2
42.0
81.8
titre
—
5
17
114
910
1.29
1.73
3.2
2.5
12.6
13.7
umol/l
0.78
107
852
464
4285
1.19
1.71
4.5
4.0
—
—
—
0
0
27
164
1.67
1.70
5.0
4.5
7.4
7.4
ph
0.90
20
135
172
1447
1.24
1.69
2.5
2.1
2.9
3.0
mg/l
0.15
146
1240
243
2122
1.21
1.66
7.3
6.1
—
—
—
0
0
7
25
2.82
1.65
1.4
2.9
—
—
—
0
0
329
2956
1.19
1.64
4.8
4.0
—
—
—
0
0
76
579
1.34
1.61
2.7
2.3
0.2
0.2
g/l
1.67
70
542
120
974
1.27
1.61
3.8
2.9
2.8
1.8
e6/l
0.55
69
541
61
815
0.73
1.60
1.3
1.4
—
—
—
0
0
218
1891
1.21
1.59
4.5
4.0
18.5
9.5
mg/mmol
0.98
147
1235
22
129
1.72
1.58
3.2
2.5
15.7
16.6
%
0.31
13
68
37
249
1.51
1.55
1.6
1.3
29.4
26.5
iu/l
0.13
31
211
120
980
1.26
1.54
3.3
3.0
2.4
2.4
mmol/l
0.02
101
870
570
5994
0.84
1.52
6.9
5.4
41.0
39.7
mmol/mol
1.91
533
5632
67
506
1.35
1.52
1.5
1.5
—
—
—
0
0
99
791
1.29
1.51
1.6
1.5
—
—
—
0
0
218
1900
1.20
1.51
3.7
3.4
2.3
2.3
mmol/l
0.18
198
1693
16
86
1.88
1.51
1.2
1.7
—
—
—
0
0
16
86
1.88
1.51
1.2
1.7
—
—
—
0
0
16
86
1.88
1.51
1.2
1.7
—
—
—
0
0
16
86
1.88
1.51
1.2
1.7
—
—
—
0
0
94
750
1.29
1.46
4.1
2.8
14.5
8.0
umol/l
0.64
83
668
34
229
1.51
1.43
1.1
1.1
—
—
—
0
0
6
22
2.74
1.43
6.0
6.5
26.9
27.0
mmol/l
—
6
22
54
720
0.73
1.42
1.6
1.4
—
—
—
0
0
60
452
1.35
1.39
2.9
3.1
175.3
185.7
ng/l
0.09
52
408
587
6137
0.85
1.35
23.4
14.0
40.4
40.9
%
0.68
415
4680
678
6994
0.82
1.31
13.0
10.0
31.5
29.3
u/l
1.36
664
6797
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
263
2367
1.16
1.23
4.5
3.4
44.6
42.6
ng/l
0.06
184
1600
21
132
1.61
1.21
2.4
2.2
128.9
131.9
g/l
0.19
16
105
54
411
1.34
1.20
6.3
3.3
7.4
7.4
ph
—
8
53
186
1631
1.18
1.20
3.1
3.1
1254.4
1225.2
ng/l
0.04
154
1384
331
3036
1.15
1.19
7.1
6.1
57.4
57.0
%
0.28
318
2865
28
190
1.49
1.17
1.4
1.4
217.9
290.7
ug/g
0.80
14
112
335
3084
1.15
1.13
7.3
6.3
27.9
28.1
%
0.07
321
2896
8
40
2.01
1.12
6.5
4.3
—
—
—
0
0
16
256
0.62
1.11
1.3
1.2
—
—
—
0
0
5
21
2.39
1.09
1.4
3.3
—
—
—
0
0
41
305
1.36
1.07
1.1
1.1
—
31.6
—
0
7
21
137
1.55
1.06
5.0
4.8
3.1
2.5
mmol/l
0.39
12
98
325
2998
1.14
1.05
7.4
6.6
8.6
8.7
%
0.35
310
2828
670
6892
0.85
1.05
19.5
12.5
—
—
—
0
0
15
90
1.68
1.04
5.8
1.3
65.7
65.2
mmol/l
—
9
81
9
46
1.97
1.03
2.8
1.4
18.3
19.3
nmol/l
—
9
41
9
46
1.97
1.03
1.7
1.4
—
—
—
0
0
161
1415
1.17
1.02
1.7
1.9
1.1
1.1
mg/l
0.01
124
1074
5
23
2.18
0.98
2.6
2.6
—
—
—
0
0
0
30
0.00
0.97
0.0
1.1
—
—
—
0
0
0
30
0.00
0.97
0.0
1.1
—
—
—
0
0
193
1727
1.15
0.97
2.6
2.7
358.1
5178.4
umol/l
4.93
169
1533
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
490
4658
1.13
0.96
3.9
3.6
14.7
14.6
pmol/l
0.05
455
4257
31
225
1.39
0.96
10.4
9.1
—
—
—
0
0
6
119
0.50
0.94
2.7
4.5
136.8
333.3
u/ml
—
6
114
15
93
1.62
0.94
1.2
1.4
—
—
—
0
0
200
1798
1.15
0.94
3.8
3.3
87.0
242.8
mg/l
1.16
138
1193
12
196
0.61
0.93
1.0
1.1
—
—
—
0
0
10
55
1.83
0.92
1.0
1.0
—
—
titre
—
0
0
215
2366
0.88
0.92
2.2
2.0
—
—
—
0
0
17
255
0.66
0.91
1.0
1.1
—
—
—
0
0
17
110
1.56
0.91
1.0
1.5
—
—
—
0
0
312
2895
1.13
0.90
7.3
6.3
0.7
0.7
%
0.32
298
2721
85
1004
0.83
0.89
1.2
1.3
7.7
13.9
u/ml
0.52
30
427
18
119
1.52
0.88
1.6
1.2
—
—
—
0
0
472
4498
1.12
0.83
3.6
3.6
—
—
—
0
0
63
761
0.81
0.83
1.8
1.6
—
—
—
0
0
320
2989
1.12
0.81
7.3
6.2
2.8
2.9
%
0.24
304
2800
55
670
0.81
0.79
1.3
1.4
—
—
—
0
0
72
604
1.21
0.79
1.7
1.7
—
—
—
0
0
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
36
278
1.31
0.78
1.1
1.5
—
9.6
—
0
9
27
359
0.74
0.77
1.5
1.7
—
—
—
0
0
55
451
1.24
0.75
1.2
1.4
—
—
—
0
0
94
813
1.18
0.75
1.4
1.2
—
—
—
0
0
9
54
1.67
0.74
1.1
1.2
—
—
—
0
0
280
2615
1.11
0.70
3.1
2.7
114.6
139.8
ug/l
1.32
259
2437
301
2827
1.10
0.67
11.8
9.3
0.0
0.0
e9/l
0.59
251
2344
30
232
1.30
0.67
3.4
3.6
711.0
4927.8
u/ml
0.48
25
198
29
369
0.78
0.63
1.2
1.2
—
—
—
0
0
11
71
1.56
0.62
1.7
1.3
—
—
—
0
0
42
510
0.81
0.62
1.5
1.4
—
—
—
0
0
20
147
1.37
0.62
2.1
1.5
—
—
—
0
0
29
227
1.29
0.60
1.3
1.3
10.8
7.4
u/l
0.39
24
187
8
51
1.57
0.60
1.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
8
52
1.54
0.59
1.3
1.3
16.3
28.3
%
—
8
37
0
22
0.00
0.59
0.0
1.4
—
131.2
—
0
16
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
20
149
1.35
0.58
1.7
1.6
27226.1
13589.3
e6/l
0.36
15
112
18
133
1.36
0.55
1.1
1.1
—
—
—
0
0
29
231
1.26
0.54
1.4
1.3
—
—
—
0
0
6
38
1.58
0.54
1.2
1.0
—
—
—
0
0
9
61
1.48
0.54
1.9
1.6
—
—
—
0
0
61
703
0.86
0.53
1.4
1.4
—
—
—
0
0
25
315
0.79
0.53
1.7
1.8
35.6
36.7
nmol/l
0.09
25
304
10
66
1.52
0.52
1.1
1.0
257.7
274.5
mg/l
—
10
61
9
134
0.67
0.52
1.1
1.1
—
—
—
0
0
9
134
0.67
0.52
1.1
1.1
—
—
—
0
0
23
179
1.29
0.51
7.0
3.3
1.9
1.5
mg/l
1.23
23
165
6
41
1.47
0.50
1.8
1.3
—
—
—
0
0
36
430
0.83
0.48
2.1
2.4
—
17.0
—
0
30
66
580
1.15
0.47
2.4
2.1
382.4
363.6
nmol/l
0.27
55
538
95
1051
0.89
0.47
1.3
1.3
22.8
31.3
iu/ml
0.66
32
341
10
68
1.48
0.47
2.3
2.9
8.8
16.0
mg/l
—
5
52
44
375
1.18
0.46
2.7
2.5
—
—
—
0
0
13
94
1.39
0.46
3.2
2.5
29.9
4.5
u/ml
0.46
13
89
16
121
1.33
0.44
1.0
1.0
—
—
—
0
0
18
140
1.29
0.42
1.5
1.4
1331.0
1451.8
e6/l
0.03
18
112
18
140
1.29
0.42
1.4
1.3
8.1
10.6
e6/l
0.12
18
108
49
561
0.87
0.41
3.5
4.4
—
—
—
0
0
8
58
1.38
0.41
1.9
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
0
17
0.00
0.40
0.0
5.2
—
—
—
0
0
18
227
0.79
0.40
1.7
2.4
17.1
44.9
u/ml
1.47
18
214
5
34
1.47
0.40
2.4
3.5
—
—
—
0
0
5
34
1.47
0.40
1.0
1.0
—
0.6
—
0
8
11
80
1.38
0.38
1.1
1.3
—
—
—
0
0
39
336
1.17
0.38
1.1
1.0
—
—
—
0
0
8
114
0.70
0.37
1.0
1.1
—
10.9
—
0
9
28
235
1.20
0.36
2.1
2.5
—
—
—
0
0
5
78
0.64
0.35
2.0
3.9
—
—
—
0
0
6
42
1.43
0.35
1.3
1.0
—
—
—
0
0
9
123
0.73
0.35
3.2
3.5
—
—
—
0
0
11
82
1.35
0.34
1.3
1.2
—
—
—
0
0
22
264
0.83
0.33
6.6
3.9
25.2
24.9
mmol/l
0.22
22
252
6
87
0.69
0.33
1.0
1.1
—
—
—
0
0
31
266
1.17
0.33
1.8
1.6
—
—
—
0
0
7
99
0.70
0.31
13.0
3.2
—
—
—
0
0
15
120
1.25
0.30
2.5
1.9
—
—
—
0
0
164
1727
0.94
0.30
4.0
3.6
—
—
—
0
0
40
355
1.13
0.28
1.4
1.2
—
—
—
0
0
10
76
1.32
0.28
1.2
1.1
—
—
—
0
0
34
299
1.14
0.28
5.1
3.6
—
—
—
0
0
8
66
1.21
0.26
1.0
1.2
—
—
—
0
0
45
405
1.12
0.26
1.4
1.2
119.8
142.9
iu/ml
0.12
19
159
658
6502
1.06
0.26
21.2
13.5
27.3
23.9
mg/l
1.84
561
5132
11
86
1.28
0.26
2.5
2.3
—
—
—
0
0
21
179
1.18
0.25
1.3
1.1
—
—
—
0
0
9
75
1.20
0.25
1.4
2.7
33.7
33.6
pg
—
9
75
68
734
0.92
0.24
2.4
2.3
13.0
13.3
nmol/l
0.12
62
665
472
4631
1.05
0.24
3.6
3.9
11.7
10.8
mm/h
0.67
437
4313
13
106
1.23
0.23
1.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
5.9
—
—
—
0
0
0
10
0.00
0.21
0.0
11.9
—
0.4
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
4.8
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
32
356
0.89
0.21
1.7
2.4
—
—
—
0
0
20
173
1.16
0.21
2.8
2.4
453.9
78.7
ug/min
—
10
102
0
13
0.00
0.21
0.0
3.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
6.6
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
3.9
—
5691.0
—
0
14
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
13
108
1.21
0.20
1.7
1.5
—
—
—
0
0
13
108
1.21
0.20
1.6
1.5
—
—
—
0
0
11
133
0.82
0.19
1.0
1.4
—
—
—
0
0
6
51
1.18
0.19
1.0
2.5
—
—
—
0
0
569
5757
0.96
0.18
4.8
4.2
1.8
2.1
mu/l
0.63
527
5303
90
854
1.06
0.18
1.3
1.3
474.3
475.3
titre
0.00
14
177
119
1241
0.95
0.17
1.5
1.4
2.9
2.5
g/l
0.83
70
821
51
475
1.08
0.17
1.2
1.2
—
—
—
0
0
171
1767
0.96
0.17
3.3
3.0
—
—
—
0
0
48
515
0.93
0.16
2.0
2.5
11.4
10.5
g/l
0.41
43
475
13
111
1.17
0.16
1.6
1.5
—
—
—
0
0
153
1480
1.04
0.15
4.8
4.6
—
—
—
0
0
9
79
1.14
0.15
2.6
2.7
—
—
—
0
0
56
527
1.07
0.15
4.5
4.7
1.1
0.8
%
0.59
24
172
14
121
1.16
0.15
1.3
1.2
—
—
—
0
0
671
6662
1.04
0.15
24.5
15.0
139.3
139.7
mmol/l
3.01
661
6493
10
118
0.85
0.14
1.1
1.2
—
—
—
0
0
80
764
1.05
0.14
1.4
1.3
—
—
—
0
0
30
276
1.09
0.13
2.9
3.5
—
—
—
0
0
8
100
0.80
0.13
1.9
1.9
—
—
—
0
0
46
489
0.94
0.13
5.1
4.8
0.3
0.2
%
0.51
18
155
18
161
1.12
0.13
1.4
1.3
459.2
503.4
mg/l
0.23
18
151
140
1359
1.04
0.12
1.4
1.2
1.5
1.7
u/ml
0.10
36
400
10
85
1.18
0.12
1.2
1.2
—
—
—
0
0
15
133
1.13
0.12
4.3
3.7
60.7
56.5
%
0.80
15
133
15
168
0.89
0.11
1.1
1.2
—
—
—
0
0
16
143
1.12
0.11
1.4
1.2
3.8
3.8
mmol/l
0.08
16
134
5
44
1.14
0.10
3.4
1.7
—
—
—
0
0
5
47
1.06
0.09
1.2
1.2
—
—
—
0
0
44
462
0.95
0.09
5.2
4.9
0.0
0.1
%
1.03
16
135
12
107
1.12
0.08
1.0
1.1
8.5
8.3
u/ml
—
6
52
7
67
1.05
0.08
3.3
2.6
—
—
—
0
0
6
70
0.86
0.07
1.2
3.1
6.9
79.4
nmol/l
—
6
70
9
87
1.03
0.07
2.6
3.4
—
—
—
0
0
9
101
0.89
0.06
1.1
1.3
—
—
—
0
0
671
6687
1.02
0.06
24.5
15.1
4.0
4.0
mmol/l
0.20
659
6514
14
129
1.09
0.05
3.6
3.2
5.3
4.2
e9/l
0.54
14
129
56
576
0.97
0.05
4.0
4.7
4.7
33.1
ug/l
1.25
47
479
186
1882
0.98
0.05
1.4
1.5
—
—
—
0
0
29
278
1.04
0.04
2.0
2.3
—
—
—
0
0
13
121
1.08
0.03
1.0
1.1
2.9
2.3
u/ml
—
6
50
20
210
0.95
0.03
1.7
1.6
—
—
—
0
0
171
1725
0.99
0.03
1.7
1.7
1.6
1.5
mmol/l
1.46
147
1485
10
108
0.93
0.03
1.1
1.5
—
—
—
0
0
552
5535
0.99
0.02
26.3
16.1
13.8
13.6
%
1.96
546
5425
49
480
1.02
0.02
3.7
4.5
1.1
0.5
%
1.04
17
127
46
451
1.02
0.02
4.0
3.2
4.2
4.2
e9/l
0.05
38
365
10
107
0.93
0.02
2.1
2.0
13.7
13.2
%
—
10
107
15
143
1.05
0.01
1.7
2.0
2.6
5.2
iu/l
—
5
48
15
152
0.99
0.00
2.7
4.5
—
—
—
0
0
21
208
1.01
0.00
4.1
4.3
0.4
0.3
g/l
—
9
103
53
532
1.00
0.00
3.9
3.6
—
—
—
0
0
77
768
1.00
0.00
2.5
2.4
184.1
123.5
ug/g
0.33
64
629
6
66
0.91
0.00
1.2
1.2
—
—
nmol/l
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
7
79
0.89
0.00
2.1
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
146.3
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
8
0.00
0.00
0.0
3.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
3.6
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
58
0.86
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
0.00
1.0
1.5
—
68.6
—
0
7
0
5
0.00
0.00
0.0
5.2
—
16.5
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.4
1.2
—
—
—
0
0
5
53
0.94
0.00
2.6
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
17.9
—
0
6

Mortality – FinRegistry

Association

Association between endpoint ST19_TOXIC_EFFECT_ALCOHOL and mortality.

Females

Parameter HR [95% CI] p-value
ST19_TOXIC_EFFECT_ALCOHOL 4.993 [3.52, 7.08] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 999 females with ST19_TOXIC_EFFECT_ALCOHOL died.

Males

Parameter HR [95% CI] p-value
ST19_TOXIC_EFFECT_ALCOHOL 5.096 [4.25, 6.11] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 587 out of 2166 males with ST19_TOXIC_EFFECT_ALCOHOL died.

Mortality risk

Mortality risk for people of age

years, who have ST19_TOXIC_EFFECT_ALCOHOL.

N-year risk Females Males
1 0.512% 0.933%
5 2.421% 5.27%
10 6.017% 13.689%
15 11.05% 24.353%
20 18.141% 38.048%

Relationships between endpoints

Index endpoint: ST19_TOXIC_EFFECT_ALCOHOL – Toxic effect of alcohol

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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