salivary gland neoplasm: ['Tumors of the SALIVARY GLANDS.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
587 |
4. Check minimum number of eventsNone |
587 |
5. Include endpointsNone |
587 |
6. Filter based on genotype QC (FinnGen only) |
587 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D33
- Name in latin
- Neoplasma benignum cerebri supratentoriale
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Brain, supratentorial
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Brain, supratentorial
- Benign neoplasm of brain and other parts of central nervous system
- Benign neoplasm of brain and other parts of central nervous system
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4145 | 2224 | 1899 |
| Only index persons | 3782 | 2059 | 1723 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 49.48 | 51.35 | 47.25 |
| Only index persons | 48.74 | 50.53 | 46.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 587 | 339 | 248 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.11 |
| Median age at first event (years) | 50.38 | 46.72 | 55.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 533
- Matched controls
- 5327
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
220.3
217.7
213
16
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
202.3
181
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
25.3
179.2
271
209
D33.07
ICD-10 Finland
Colloid coast in cerebral ventricle
+∞
135.3
124
*
D33.02
ICD-10 Finland
Another benign medial tumor of the cerebrum
+∞
94.6
88
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
63.1
81.5
94
18
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
13.7
75.9
139
134
D33.08
ICD-10 Finland
Another benign tumor of the cerebral ventricle
+∞
73.7
69
*
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
60.3
70.6
82
16
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
9.4
67.4
152
216
D33.05
ICD-10 Finland
Other lateral benign tumor in temporal lobe
+∞
60.6
57
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
17.8
59.3
95
64
N03AF02
ATC
oxcarbazepine; oral
15.2
54.5
93
73
D33.30
ICD-10 Finland
Acoustic neuroma
77.8
50.1
56
8
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
23.1
47.6
69
34
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
110.1
46.6
50
5
AA1AD
NOMESCO Finland
CT of head and brain
4.3
46.5
220
746
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
57.4
44.5
52
10
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
20.7
44.0
66
36
N03AX14
ATC
levetiracetam; systemic
14.9
43.4
74
57
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
41.8
42.8
53
14
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
17.0
40.4
65
43
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
17.3
39.4
63
41
D33.0
ICD-10 Finland
Benign neoplasm: Brain, supratentorial
+∞
38.0
36
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
75.6
37.5
42
6
ZXC95
NOMESCO Finland
Use of surgical navigator
30.1
35.3
47
17
G40.9
ICD-10 Finland
Epilepsy, unspecified
11.7
32.9
62
59
XA800
NOMESCO Finland
Neuropsychological investigation
8.5
30.4
69
92
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
23.3
27.4
39
18
R51.80
ICD-10 Finland
Headache
3.6
26.8
138
467
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.7
26.0
69
116
N03AG01
ATC
valproic acid; systemic, rectal
6.2
25.7
72
130
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
15.6
25.6
42
29
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
25.4
142
510
D33.04
ICD-10 Finland
Temporal lobe
+∞
25.2
24
*
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
58.9
24.3
28
5
D33.01
ICD-10 Finland
Medial ganglion glioma of the cerebrum
+∞
24.1
23
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
250.6
23.8
24
*
H53.4
ICD-10 Finland
Visual field defects
14.9
23.5
39
28
D33.03
ICD-10 Finland
Pilosytic lateral astrocytoma of the strobe brain
+∞
23.1
22
*
H02AB02
ATC
dexamethasone; systemic
4.2
22.8
94
259
XCK00
NOMESCO Finland
Perimetry
4.9
22.2
77
178
N03AB02
ATC
phenytoin; systemic
24.3
21.5
30
13
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
24.3
21.5
30
13
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
21.5
133
506
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
29.4
21.1
28
10
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
80.0
20.8
23
*
N03AF01
ATC
carbamazepine; oral, rectal
6.1
20.8
58
104
D33.2
ICD-10 Finland
Benign neoplasm: Brain, unspecified
218.0
20.7
21
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
14.6
19.8
33
24
183
Kela drug reimbursment
Lamotrigin and topiramate
23.6
19.2
27
12
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
54.5
18.1
21
*
D33.06
ICD-10 Finland
Plexus papilloma of the ventricle of the brain
+∞
17.8
17
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
21.8
16.1
23
11
G93.0
ICD-10 Finland
Cerebral cysts
34.5
15.8
20
6
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
29.6
15.3
20
7
N03AX18
ATC
lacosamide; systemic
14.7
14.7
24
17
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
82.4
14.6
16
*
H02AB09
ATC
hydrocortisone; systemic
7.9
14.6
33
44
9530/0-C70.9
ICD-O-3
Meningioma, NOS, of meninges, NOS
153.9
14.5
15
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.8
14.1
62
179
N88
ICPC
Epilepsy
30.9
14.0
18
6
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
77.1
13.6
15
*
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
13.3
13.5
23
18
N76
ICPC
Neoplasm nervous system unspecified
143.4
13.5
14
*
E23.00
ICD-10 Finland
Panhypopituitarism
41.2
13.2
16
*
WX882
NOMESCO Finland
High dependency care
5.5
13.1
39
76
L01AX03
ATC
temozolomide; systemic
17.2
13.1
20
12
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
12.9
71
242
2152
FHL
Extraction, big brain
71.6
12.6
14
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
71.6
12.6
14
*
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
32.9
12.6
16
5
D32.03
ICD-10 Finland
Benign meningioma in ventricles
132.9
12.5
13
*
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
27.4
12.1
16
6
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
12.0
167
953
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
47.8
11.9
14
*
G40.10
ICD-10 Finland
Simple partial seizures
16.9
11.7
18
11
N05BA09
ATC
clobazam; oral
14.0
11.5
19
14
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.1
11.5
65
228
9505/1-C71.9
ICD-O-3
Ganglioglioma, NOS, of brain, NOS
+∞
11.5
11
*
D33.3
ICD-10 Finland
Benign neoplasm: Cranial nerves
+∞
11.5
11
*
N75
ICPC
Benign neoplasm nervous system
+∞
11.5
11
*
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
+∞
11.5
11
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.3
11.4
59
195
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
9.2
11.4
23
26
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
13.1
11.2
19
15
C71.11
ICD-10 Finland
Malignant tumor of frontal lobe grade II glioma
25.6
11.2
15
6
TAB00
NOMESCO Finland
Lumbar puncture
4.4
11.1
40
97
AA1BD
NOMESCO Finland
Extensive CT of head and brain
6.5
11.1
28
45
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
44.3
11.0
13
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
28.7
10.8
14
5
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
61.2
10.7
12
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
61.2
10.7
12
*
D33.10
ICD-10 Finland
Benign pilosytic astrocytoma of brain stem
+∞
10.4
10
*
R42
ICD-10 Finland
Dizziness and giddiness
2.1
10.1
123
654
H53.2
ICD-10 Finland
Diplopia
5.5
10.1
29
55
G40
ICD-10 Finland
Epilepsy
14.9
10.0
16
11
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
40.9
10.0
12
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
26.6
9.8
13
5
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
9.7
52
176
N03AX09
ATC
lamotrigine; oral
4.0
9.7
38
100
AAF00
NOMESCO Finland
Ventriculostomy
13.7
9.7
16
12
101
Kela drug reimbursment
Anterior pituitary hypofunction
13.7
9.7
16
12
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
101.7
9.4
10
*
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
101.7
9.4
10
*
H02.2
ICD-10 Finland
Lagophthalmos
101.7
9.4
10
*
9421/1-C71.9
ICD-O-3
Pilocytic astrocytoma of brain, NOS
+∞
9.4
9
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
+∞
9.4
9
*
C71.50
ICD-10 Finland
Malignant tumor of cerebral ventricle without histology
+∞
9.4
9
*
D32.04
ICD-10 Finland
Secondary or multiple benign tumor of the meninges above the exam
+∞
9.4
9
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
11.7
9.1
16
14
ZXC40
NOMESCO Finland
Use of ultrasound
11.7
9.1
16
14
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
14.3
8.7
14
10
Q28.3
ICD-10 Finland
Other malformations of cerebral vessels
50.8
8.7
10
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
11.8
8.6
15
13
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
20.4
8.5
12
6
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
91.4
8.4
9
*
2250A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Brain
91.4
8.4
9
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.6
8.4
28
64
2252A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Cerebral meninges
+∞
8.3
8
*
N05AX08
ATC
risperidone; systemic
2.9
8.3
49
179
ZXC86
NOMESCO Finland
Use of endoscopic device
14.8
8.2
13
9
H47.2
ICD-10 Finland
Optic atrophy
17.5
8.1
12
7
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
33.9
8.1
10
*
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
33.9
8.1
10
*
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
22.4
8.0
11
5
R4110
NOMESCO Finland
Physiotherapy
1.9
8.0
146
902
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
8.0
42
142
R51
ICD-10 Finland
Headache
3.3
8.0
39
125
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
15.3
7.7
12
8
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
45.6
7.7
9
*
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
45.6
7.7
9
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
45.6
7.7
9
*
G44.2
ICD-10 Finland
Tension-type headache
2.3
7.7
76
365
D32.07
ICD-10 Finland
Secondary or multiple benign tumor of the meninges below the exam
81.1
7.4
8
*
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.1
7.3
13
12
D33.37
ICD-10 Finland
Another benign tumor of the cranial nerves
+∞
7.3
7
*
9413/0-C71.9
ICD-O-3
Dysembryoplastic neuroepithelial tumor of brain, NOS
+∞
7.3
7
*
D33.11
ICD-10 Finland
Brain stem
+∞
7.3
7
*
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
20.3
7.2
10
5
ZX050
NOMESCO Finland
Stereotactic radiotherapy
12.2
7.1
12
10
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
10.2
7.1
13
13
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.1
7.0
16
23
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
6.0
7.0
18
31
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.3
6.6
58
265
WF002
NOMESCO Finland
Radical radiotherapy
3.3
6.5
31
98
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
70.6
6.4
7
*
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
70.6
6.4
7
*
ZZC00
NOMESCO Finland
Graft of fascia
70.6
6.4
7
*
AAJ20
NOMESCO Finland
Excision of epileptic focus
70.6
6.4
7
*
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
70.6
6.4
7
*
AA1AA
NOMESCO Finland
Head X-ray examination
18.3
6.3
9
5
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
6.3
6
*
D44.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pineal gland
+∞
6.3
6
*
9505/1-C71.2
ICD-O-3
Ganglioglioma, NOS, of temporal lobe
+∞
6.3
6
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
6.2
75
395
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.2
114
698
N03AX11
ATC
topiramate; oral
4.0
6.1
23
60
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
6.1
80
435
WF099
NOMESCO Finland
Other radiotherapy
12.7
6.1
10
8
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
6.8
6.1
14
21
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
38
13.36
48.36
1.3
1.7
—
—
—
0
0
146
470
3.80
38.99
6.8
8.6
1.4
1.3
mmol/l
0.17
105
379
145
470
3.77
38.28
6.8
8.5
15.9
12.7
kpa
5.61
135
456
145
470
3.77
38.28
6.8
8.5
5.1
5.1
kpa
0.39
136
453
38
39
10.35
33.31
2.5
1.3
—
—
—
0
0
357
2191
2.61
27.70
7.5
6.8
1.2
1.2
mmol/l
1.85
335
1855
27
22
12.82
27.40
1.8
1.3
—
—
—
0
0
331
1982
2.54
26.72
7.0
6.1
1.2
1.2
mmol/l
4.42
313
1805
52
108
5.19
24.11
2.2
1.6
16.2
11.9
e6/l
0.16
44
86
52
108
5.19
24.11
2.3
1.7
2750.9
149.2
e6/l
0.79
44
89
51
108
5.08
23.12
2.0
1.6
3.5
3.7
mmol/l
0.41
46
99
230
1328
2.20
18.21
2.6
2.0
273.7
233.9
u/l
0.14
222
1254
106
448
2.67
16.81
3.4
1.9
302.6
368.6
nmol/l
2.85
97
412
376
2716
2.07
15.55
6.3
4.8
6.4
6.6
mmol/l
1.63
360
2515
114
533
2.41
14.50
7.0
6.5
—
—
—
0
0
130
677
2.18
12.70
2.3
2.1
28.1
29.7
s
3.99
130
662
30
69
4.53
12.29
5.2
4.8
373.7
384.9
umol/l
0.14
25
61
19
30
6.51
11.61
1.1
1.0
—
—
—
0
0
175
1109
1.82
9.43
2.3
2.2
—
—
—
0
0
297
2190
1.72
9.42
3.7
3.9
—
—
—
0
0
21
52
4.15
7.86
1.0
1.1
—
—
—
0
0
21
54
4.00
7.49
1.0
1.1
—
—
—
0
0
118
717
1.81
7.09
1.8
1.9
—
—
—
0
0
251
1871
1.60
6.95
4.9
4.6
35.6
36.1
g/l
0.67
234
1746
39
156
2.61
6.83
2.6
1.4
7.7
9.5
u/l
0.31
30
123
430
3662
1.65
6.62
4.9
3.9
14.5
14.6
pmol/l
0.30
404
3317
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
14
29
4.92
6.48
1.1
1.1
—
—
—
0
0
342
2777
1.55
6.29
9.8
9.1
4.3
4.0
e9/l
0.81
296
2442
9
5
18.25
6.28
1.4
1.2
—
—
—
0
0
85
491
1.85
5.98
1.7
1.9
—
—
—
0
0
110
689
1.73
5.90
3.4
3.8
0.8
0.8
mmol/l
0.69
104
652
84
486
1.85
5.87
1.7
1.8
—
—
—
0
0
17
45
3.86
5.85
1.1
1.1
—
—
—
0
0
222
1683
1.51
5.35
3.6
3.5
49.1
34.7
ng/l
0.46
152
1110
296
2383
1.49
5.30
6.7
6.1
9.6
11.6
umol/l
4.59
279
2254
37
169
2.27
4.92
1.3
1.4
—
—
—
0
0
413
3586
1.51
4.89
8.2
7.2
76.6
78.7
u/l
0.47
391
3360
524
4840
1.77
4.46
17.7
12.8
23.5
21.9
mg/l
0.53
452
3774
195
1487
1.47
4.39
2.9
3.2
2.3
2.4
mmol/l
1.35
164
1325
10
22
4.61
4.31
1.3
1.2
—
—
—
0
0
11
27
4.13
4.18
1.0
1.1
—
—
—
0
0
221
1749
1.42
4.00
2.1
1.9
93.7
95.6
pmol/l
0.24
108
930
87
574
1.61
3.79
6.1
5.7
1.0
1.0
mmol/l
0.02
77
533
142
1044
1.48
3.78
5.1
3.6
1.0
1.0
kg/l
0.42
22
134
238
1930
1.39
3.67
2.3
2.3
73.1
75.4
nmol/l
0.83
215
1733
398
3518
1.41
3.63
4.7
4.0
10.9
11.1
mm/h
0.14
372
3249
8
13
6.22
3.51
1.1
1.3
—
—
—
0
0
8
13
6.22
3.51
1.0
1.1
—
—
—
0
0
8
13
6.22
3.51
1.0
1.2
—
—
—
0
0
6
6
10.09
3.50
1.3
1.2
2.4
7.7
nmol/l
—
6
6
17
64
2.71
3.42
1.1
1.1
—
—
—
0
0
204
1628
1.39
3.41
3.9
3.2
—
—
—
0
0
43
241
1.85
3.37
2.4
1.4
26.4
24.2
iu/l
0.15
37
200
8
14
5.78
3.35
1.0
1.3
—
—
—
0
0
15
54
2.82
3.27
2.2
1.3
0.7
0.5
nmol/l
0.74
15
48
8
15
5.39
3.20
1.0
1.1
—
—
—
0
0
8
15
5.39
3.20
1.0
1.2
—
—
—
0
0
9
20
4.55
3.12
1.7
1.1
—
—
—
0
0
80
543
1.55
3.10
17.5
19.2
1.5
1.2
inr
0.72
12
82
540
5117
1.69
3.04
12.2
9.8
27.4
26.5
u/l
0.45
527
4938
7
12
5.89
3.03
1.7
2.1
26.5
17.7
umol/l
—
7
12
30
159
1.93
2.81
2.7
1.7
1.7
3.7
ug/l
0.47
23
138
8
18
4.49
2.80
1.1
1.1
2.9
5.5
umol/l
—
8
18
32
174
1.89
2.78
1.5
1.7
—
—
—
0
0
55
351
1.63
2.77
3.1
2.4
7.0
6.4
ug/l
0.11
49
314
476
4413
1.42
2.76
5.5
4.6
2.0
2.1
mu/l
0.22
440
4043
55
353
1.62
2.71
2.7
2.3
12.5
12.9
nmol/l
0.16
50
316
105
779
1.42
2.63
1.9
1.7
1101.4
1181.7
nmol/l
0.46
85
597
5
7
7.19
2.55
1.0
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
109
2.06
2.49
2.3
2.8
0.4
0.3
u/ml
—
9
60
102
763
1.41
2.44
3.5
2.6
1.5
0.9
e6/l
0.77
66
433
23
117
2.01
2.43
1.2
1.2
—
—
—
0
0
174
1421
1.32
2.37
2.9
2.4
55.9
55.9
u/l
0.00
157
1318
5
8
6.29
2.37
1.6
1.8
—
—
—
0
0
27
147
1.88
2.37
1.6
1.5
0.1
0.0
iu/ml
—
9
27
274
2379
1.28
2.35
4.6
3.4
0.0
0.0
estimate
0.50
39
432
5
9
5.59
2.21
1.0
1.3
—
—
—
0
0
5
9
5.59
2.21
1.0
1.3
—
—
—
0
0
46
299
1.58
2.19
1.7
1.5
—
—
—
0
0
156
1269
1.31
2.17
5.2
3.7
0.0
0.0
estimate
0.69
38
450
9
30
3.03
2.15
1.0
1.1
—
—
—
0
0
40
254
1.62
2.10
1.8
1.6
—
—
—
0
0
18
89
2.05
2.08
1.9
1.4
0.2
0.3
nmol/l
0.61
12
70
103
793
1.36
2.08
2.9
2.7
2.4
2.4
mmol/l
1.76
89
703
7
20
3.53
2.06
1.0
1.1
1556.7
1338.0
miu/ml
—
7
20
266
2329
1.26
2.05
4.7
3.4
0.0
0.0
estimate
0.00
41
448
268
2349
1.26
2.04
6.0
4.6
0.0
0.0
estimate
0.00
39
456
9
32
2.84
2.00
1.0
1.3
—
—
—
0
0
58
406
1.48
1.99
4.6
4.6
2.1
1.7
mmol/l
0.40
50
326
7
21
3.36
1.97
1.0
1.0
—
—
—
0
0
29
468
0.60
1.96
1.7
1.6
—
—
—
0
0
31
189
1.68
1.91
1.6
1.9
—
—
—
0
0
47
320
1.51
1.85
2.9
3.8
5.0
5.1
kpa
0.34
41
304
140
1154
1.28
1.74
2.8
2.1
2.8
2.9
mg/l
0.48
117
986
105
834
1.32
1.73
3.7
3.6
80.2
274.4
ng/l
2.26
73
607
5
13
3.87
1.72
1.0
1.2
—
—
—
0
0
47
326
1.48
1.71
1.5
1.9
—
—
—
0
0
16
82
1.98
1.71
1.3
1.2
4.6
4.2
u/ml
—
10
37
44
303
1.49
1.66
2.9
3.9
0.7
1.6
mmol/l
1.01
33
218
15
76
2.00
1.65
1.1
1.1
—
—
—
0
0
72
544
1.37
1.65
4.4
4.3
31.4
32.0
%
0.19
54
355
125
1025
1.28
1.62
1.6
1.5
20.2
20.5
nmol/l
0.07
107
869
5
14
3.59
1.62
1.4
1.1
—
—
—
0
0
354
3253
1.22
1.59
4.2
3.0
51.6
43.7
u/l
1.11
337
3067
141
1187
1.25
1.47
2.9
3.1
738.3
1140.9
ng/l
1.80
120
1014
149
1267
1.24
1.41
3.9
3.0
0.3
0.3
e6/l
0.30
122
948
183
1591
1.22
1.40
3.8
3.1
28.7
31.8
u/l
0.92
170
1523
7
29
2.43
1.39
3.7
2.9
—
—
—
0
0
55
411
1.37
1.37
1.8
2.0
—
—
—
0
0
25
159
1.60
1.37
1.8
1.3
—
—
—
0
0
468
4463
1.24
1.30
14.9
11.9
86.5
84.4
ml/min/173m2
1.17
402
3638
48
355
1.38
1.28
2.1
2.6
70.9
69.6
ml/min/173m2
0.07
14
149
240
2156
1.19
1.28
3.1
2.7
106.0
105.6
ug/l
0.01
217
2000
8
35
2.30
1.27
1.6
1.7
—
—
—
0
0
89
724
1.27
1.24
3.6
2.8
2.0
2.4
e6/l
0.29
54
398
6
26
2.32
1.19
1.2
1.7
—
—
—
0
0
6
26
2.32
1.19
1.2
1.7
—
—
—
0
0
12
65
1.86
1.14
1.0
1.3
—
—
—
0
0
38
277
1.40
1.13
1.5
1.4
—
—
—
0
0
25
168
1.51
1.11
1.7
2.2
—
—
—
0
0
100
847
1.22
1.00
1.2
1.3
37.4
32.1
iu/ml
0.10
27
263
13
76
1.73
0.99
1.1
1.1
—
—
—
0
0
52
409
1.30
0.97
3.4
2.5
0.2
0.2
g/l
0.26
46
385
106
909
1.20
0.94
1.6
1.7
438.2
6570735.8
pmol/l
0.50
92
761
9
52
1.74
0.92
1.6
1.8
—
—
—
0
0
42
324
1.32
0.91
4.9
3.9
89.7
77.0
ng/l
0.34
34
289
46
360
1.30
0.90
1.1
1.2
174.8
177.2
iu/ml
0.01
18
156
6
30
2.01
0.87
1.7
1.6
—
—
—
0
0
133
1173
1.17
0.86
2.4
2.8
331.5
6918.7
umol/l
4.63
117
1025
13
80
1.64
0.85
2.3
2.6
18.2
15.7
%
—
7
40
22
307
0.71
0.84
1.4
1.5
—
—
—
0
0
10
57
1.77
0.84
1.2
1.6
—
—
—
0
0
18
121
1.50
0.83
1.5
1.7
—
—
—
0
0
20
138
1.47
0.82
1.4
1.3
—
—
—
0
0
13
81
1.62
0.82
1.3
1.7
—
—
—
0
0
14
89
1.59
0.82
1.0
2.2
143.3
128.8
g/l
—
9
64
20
139
1.45
0.80
1.2
1.1
—
—
—
0
0
16
106
1.52
0.79
1.1
1.7
—
—
—
0
0
8
48
1.68
0.79
6.5
3.1
1.8
6.8
nmol/l
—
8
48
74
626
1.21
0.77
1.9
1.8
1.6
1.5
%
0.50
68
557
42
333
1.28
0.77
1.9
3.0
68.5
67.0
g/l
0.64
36
301
9
53
1.71
0.75
1.2
1.7
—
—
—
0
0
17
116
1.48
0.75
1.5
1.7
—
—
—
0
0
201
1846
1.14
0.74
5.1
3.4
—
—
—
0
0
16
108
1.49
0.74
1.5
1.2
—
—
—
0
0
7
38
1.85
0.73
4.7
2.4
—
—
—
0
0
11
69
1.61
0.68
1.2
2.3
3.0
62.2
u/ml
0.50
11
63
5
27
1.86
0.68
1.4
1.9
—
—
—
0
0
7
42
1.67
0.68
1.4
1.2
—
79.0
—
0
6
118
1052
1.15
0.68
2.0
1.8
1.4
1.2
mg/l
0.29
90
803
7
43
1.64
0.67
1.0
1.1
—
—
—
0
0
7
43
1.64
0.67
1.0
1.1
—
—
—
0
0
12
178
0.67
0.65
1.3
1.5
—
—
—
0
0
10
62
1.62
0.65
1.4
1.7
—
—
—
0
0
11
166
0.66
0.65
2.3
1.6
—
—
—
0
0
7
44
1.60
0.65
1.0
1.1
—
—
—
0
0
7
44
1.60
0.65
1.0
1.1
—
—
—
0
0
7
44
1.60
0.65
1.0
1.1
—
—
—
0
0
15
104
1.45
0.63
1.2
1.2
—
11.9
—
0
7
24
182
1.33
0.62
1.4
1.3
179.0
257.3
miu/ml
—
10
92
13
88
1.49
0.61
1.5
1.7
—
—
—
0
0
20
148
1.36
0.60
1.3
2.9
2.9
3.2
g/l
1.23
13
118
11
72
1.54
0.59
1.4
1.7
—
—
—
0
0
11
72
1.54
0.59
1.6
1.6
—
—
—
0
0
10
64
1.57
0.59
1.2
1.7
—
—
—
0
0
21
158
1.34
0.58
1.3
2.8
3.7
3.8
g/l
0.05
13
117
21
158
1.34
0.58
1.3
2.8
7.4
7.5
g/l
0.15
14
122
21
158
1.34
0.58
1.3
2.8
—
—
—
0
0
18
132
1.38
0.57
1.2
1.2
—
2.8
—
0
16
8
55
1.46
0.56
1.9
1.4
—
—
—
0
0
6
37
1.63
0.55
1.0
1.1
—
—
—
0
0
350
3363
1.10
0.53
3.1
3.2
—
—
—
0
0
6
41
1.47
0.50
2.0
2.3
—
—
—
0
0
144
1328
1.11
0.50
4.9
4.8
4.0
2.3
ug/l
0.64
128
1188
7
45
1.56
0.49
12.4
2.9
29.3
51.6
u/ml
—
7
45
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
12
166
0.72
0.48
1.3
1.4
—
—
—
0
0
12
166
0.72
0.48
1.3
1.4
—
—
—
0
0
12
166
0.72
0.48
1.3
1.4
—
—
—
0
0
12
166
0.72
0.48
1.3
1.4
—
—
—
0
0
14
102
1.38
0.47
1.0
1.3
—
—
—
0
0
31
255
1.23
0.46
2.1
2.6
0.2
0.1
e6/l
0.39
31
246
79
707
1.14
0.45
3.1
2.2
13.3
13.4
umol/l
0.04
70
656
9
127
0.70
0.44
1.1
1.7
—
—
—
0
0
115
1057
1.11
0.43
4.6
4.3
22.6
21.2
%
0.59
65
483
5
33
1.52
0.41
1.2
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
2.4
—
0
10
0
15
0.00
0.41
0.0
1.1
—
97.5
—
0
15
13
172
0.75
0.41
3.8
3.2
109.2
1741.7
u/ml
0.93
13
147
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
465
4554
1.10
0.41
4.8
4.3
5.7
5.9
mmol/l
3.16
424
4164
19
150
1.28
0.40
6.2
5.2
1.2
1.4
mg/l
1.32
19
138
152
1422
1.09
0.40
4.4
3.2
8.1
7.8
mmol/l
0.30
132
1214
5
35
1.43
0.39
4.6
2.4
0.2
0.2
e9/l
—
5
30
5
36
1.39
0.38
1.2
1.3
2387.2
185000.8
e6/l
—
5
25
5
36
1.39
0.38
4.6
2.3
419.0
492.6
e6/l
—
5
30
8
112
0.71
0.37
1.5
1.5
—
—
—
0
0
81
742
1.11
0.34
1.9
2.2
—
—
—
0
0
89
820
1.10
0.33
1.3
1.3
4.3
11.9
u/ml
1.29
35
325
7
99
0.70
0.31
1.0
1.5
—
—
—
0
0
38
430
0.88
0.30
4.0
2.4
33.7
31.0
u/l
0.15
31
363
12
93
1.30
0.30
2.1
1.8
—
—
—
0
0
18
148
1.22
0.29
2.1
1.8
36.3
38.4
nmol/l
0.16
18
142
35
307
1.15
0.29
2.9
3.0
173.5
168.4
ng/l
0.02
30
270
16
195
0.82
0.29
1.3
1.9
—
—
—
0
0
9
77
1.17
0.24
1.3
1.5
—
—
—
0
0
14
115
1.22
0.23
1.1
1.2
—
—
—
0
0
12
147
0.81
0.23
1.3
1.5
—
—
—
0
0
11
88
1.25
0.22
3.7
3.2
4.2
4.2
e9/l
0.02
11
88
15
125
1.21
0.22
2.0
1.9
2.0
7.0
iu/l
—
6
38
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
73
684
1.08
0.21
1.8
2.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
25.1
—
0
13
0
13
0.00
0.21
0.0
1.4
—
8.4
—
0
8
17
145
1.18
0.21
1.2
1.2
—
—
—
0
0
82
773
1.07
0.20
2.7
2.9
0.8
0.8
ug/l
0.23
53
485
6
52
1.16
0.19
1.3
1.5
—
—
—
0
0
6
52
1.16
0.19
1.3
1.5
—
—
—
0
0
6
52
1.16
0.19
1.3
1.5
—
—
—
0
0
17
196
0.86
0.19
1.4
1.8
2.7
3.6
mg/l
—
9
145
65
610
1.07
0.18
3.5
2.2
20.8
22.9
%
0.70
54
534
11
91
1.21
0.17
4.1
3.6
60.6
56.5
%
0.52
11
91
7
63
1.11
0.17
1.0
1.3
—
—
—
0
0
17
148
1.15
0.17
1.2
1.1
—
—
—
0
0
10
83
1.21
0.15
1.1
1.3
—
—
—
0
0
10
83
1.21
0.15
1.1
1.3
—
—
—
0
0
9
79
1.14
0.15
1.1
1.3
—
—
—
0
0
13
112
1.16
0.14
2.2
1.9
177.4
230.3
pmol/l
0.79
13
103
416
4113
1.04
0.14
20.7
15.7
13.6
13.6
%
0.24
416
4036
44
412
1.07
0.14
3.4
4.4
4.6
35.5
ug/l
0.93
35
334
14
122
1.15
0.14
1.1
1.3
—
—
—
0
0
121
1170
1.04
0.13
1.5
1.3
1.0
2.1
u/ml
0.96
28
311
137
1329
1.04
0.13
4.1
4.1
6.5
9.7
mg/mmol
0.51
93
853
13
114
1.14
0.12
1.3
1.3
—
—
—
0
0
454
4504
1.04
0.11
19.9
13.7
39.4
40.2
%
1.22
320
3416
13
115
1.13
0.10
1.2
1.2
0.1
3.1
u/ml
—
5
52
29
271
1.07
0.10
1.3
1.3
—
—
—
0
0
6
57
1.05
0.08
1.0
1.0
—
—
—
0
0
106
1034
1.03
0.08
1.5
1.6
—
—
—
0
0
79
814
0.97
0.08
1.3
1.4
—
—
—
0
0
7
65
1.08
0.08
1.0
1.4
—
—
—
0
0
7
65
1.08
0.08
1.0
1.4
—
—
—
0
0
15
163
0.92
0.07
1.3
1.4
—
—
—
0
0
9
88
1.02
0.07
1.2
1.1
—
—
—
0
0
464
4663
0.98
0.06
4.5
4.2
4.7
4.7
mmol/l
0.38
439
4336
123
1252
0.98
0.06
1.7
1.7
1.5
1.4
mmol/l
0.41
109
1062
426
4283
0.98
0.06
5.9
5.5
38.3
39.5
mmol/mol
2.50
395
3994
18
168
1.07
0.06
1.6
1.6
—
—
—
0
0
10
90
1.11
0.05
2.3
1.5
—
—
—
0
0
15
139
1.08
0.05
1.5
1.6
—
—
—
0
0
15
140
1.07
0.04
2.6
2.6
—
—
—
0
0
447
4483
0.99
0.02
4.0
3.8
1.2
1.3
mmol/l
0.60
417
4137
67
659
1.02
0.02
3.3
2.2
2.3
2.4
g/l
0.19
59
611
27
279
0.97
0.02
1.0
1.0
—
—
—
0
0
44
449
0.98
0.02
4.2
3.1
—
—
—
0
0
463
4637
0.99
0.01
4.5
4.1
1.5
1.5
mmol/l
0.59
433
4289
21
204
1.03
0.00
1.4
1.4
—
—
—
0
0
14
144
0.97
0.00
1.2
1.1
—
11.7
—
0
17
52
525
0.99
0.00
3.2
2.8
8.6
8.3
umol/l
0.03
40
462
474
4737
1.00
0.00
5.0
4.6
2.8
2.8
mmol/l
0.01
442
4383
0
8
0.00
0.00
0.0
1.8
—
1.2
—
0
8
6
65
0.92
0.00
1.0
1.4
—
—
—
0
0
6
64
0.94
0.00
1.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.0
1.3
—
—
—
0
0
5
54
0.93
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
52.4
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BRAIN_SUPRATENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BRAIN_SUPRATENT | 1.794 [1.53, 2.1] | < 0.001 |
| Birth year | 1.003 [1.0, 1.01] | 0.441 |
During the follow-up period (1.1.1998 — 31.12.2019), 355 out of 1970 females with CD2_BENIGN_BRAIN_SUPRATENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BRAIN_SUPRATENT | 2.162 [1.81, 2.59] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 363 out of 1653 males with CD2_BENIGN_BRAIN_SUPRATENT died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BRAIN_SUPRATENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.206% | 0.378% |
| 5 | 1.309% | 2.719% |
| 10 | 2.936% | 7.058% |
| 15 | 5.921% | 13.53% |
| 20 | 11.166% | 22.667% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BRAIN_SUPRATENT – Benign neoplasm: Brain, supratentorial
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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