No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
820 |
4. Check minimum number of eventsNone |
820 |
5. Include endpointsNone |
820 |
6. Filter based on genotype QC (FinnGen only) |
820 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E78
- Name in latin
- Hypertriglyceridaemia pura
Similar endpoints
↥List of similar endpoints to
Pure hyperglyceridaemia
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5770 | 2211 | 3519 |
| Only index persons | 5271 | 2040 | 3231 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.06 | 0.10 |
| Only index persons | 0.10 | 0.07 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 60.41 | 67.97 | 55.72 |
| Only index persons | 60.07 | 67.69 | 55.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 820 | 299 | 521 |
| Unadjusted period prevalence (%) | 0.18 | 0.10 | 0.23 |
| Median age at first event (years) | 58.05 | 60.22 | 56.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 743
- Matched controls
- 7429
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E78.11
ICD-10 Finland
Other hypertriglyceridemia
6357.2
323.0
454
*
E78.10
ICD-10 Finland
Familial hypertriglyceridemia
2817.7
238.8
218
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
14.9
166.0
306
333
C10AB05
ATC
fenofibrate; oral
69.1
150.3
171
32
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
6.5
107.3
358
931
E78.1
ICD-10 Finland
Pure hyperglyceridaemia
145.8
96.7
101
8
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
19.3
92.6
145
92
C10AA01
ATC
simvastatin; oral
4.8
88.4
472
1964
C10AA05
ATC
atorvastatin; oral
4.9
88.1
443
1729
103
Kela drug reimbursment
Diabetes, insulin-treated
5.0
83.0
362
1196
A10BA02
ATC
metformin; oral
4.8
81.9
371
1270
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.0
80.8
334
1034
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
73.8
80.6
91
14
I10
ICD-10 Finland
Essential (primary) hypertension
4.4
73.4
552
2949
C10AA07
ATC
rosuvastatin; oral
4.4
64.0
291
943
A10AE04
ATC
insulin glargine; parenteral
7.1
60.5
162
282
T90
ICPC
Diabetes non-insulin dependent
4.1
58.3
292
1017
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
209.3
56.9
58
*
C10AX09
ATC
ezetimibe; oral
6.2
53.0
157
309
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
9.6
49.6
106
127
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
6.1
49.0
146
287
C10AB02
ATC
bezafibrate; oral
41.4
49.0
61
16
B01AC04
ATC
clopidogrel; oral
4.6
48.7
193
524
C07AB07
ATC
bisoprolol; oral
2.9
42.7
421
2286
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
8.5
42.5
97
129
A10BK03
ATC
empagliflozin; oral
6.3
41.0
116
211
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.4
39.2
230
860
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
6.1
39.1
114
215
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
8.4
38.5
88
117
A10BH01
ATC
sitagliptin; oral
4.9
37.2
134
322
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.3
37.1
226
862
C03CA01
ATC
furosemide; systemic
3.0
36.9
277
1226
E66.00
ICD-10 Finland
Metabolic syndrome
6.7
36.4
97
162
2721X
ICD-9 Finland
Disorders of lipoid metabolism, Pure hyperglyceridaemia[HYPERTRIGLYCERIDAEMIA ALIA]
+∞
35.7
34
*
SPAT1262
SPAT
Handing over of treatment supplies
3.4
35.5
209
775
C10AB04
ATC
gemfibrozil; oral
35.0
33.5
43
13
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
3.4
33.4
191
689
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
32.9
388
2212
AN1
HP
Coronary angiography
4.1
32.7
140
396
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.1
32.6
224
918
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
23.9
31.7
45
20
C08CA01
ATC
amlodipine; oral
2.6
31.6
318
1647
A10BJ02
ATC
liraglutide; parenteral
11.8
30.5
57
52
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
24.6
29.9
42
18
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.7
29.3
266
1284
C01DA14
ATC
isosorbide mononitrate; oral
3.5
29.2
152
505
E66.01
ICD-10 Finland
Obesity due to excess calories
5.5
29.0
90
181
A10BJ06
ATC
semaglutide; parenteral
9.3
28.8
61
71
C09AA05
ATC
ramipril; oral
2.7
28.1
237
1092
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.2
27.7
169
630
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.9
27.6
193
790
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
4.1
27.5
114
311
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
8.8
27.1
59
72
205
Kela drug reimbursment
Chronic hypertension
2.5
26.7
264
1325
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.7
26.6
95
223
M04AA01
ATC
allopurinol; systemic
3.3
26.5
152
541
AA1AD
NOMESCO Finland
CT of head and brain
2.7
25.5
211
951
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
5.1
25.3
84
182
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
4.5
24.9
94
233
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
24.8
197
864
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
8.7
24.3
53
65
G47.3
ICD-10 Finland
Sleep apnoea
2.6
24.2
210
969
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
22.9
229
1139
M10.9
ICD-10 Finland
Gout, unspecified
4.3
22.6
88
225
A10BH05
ATC
linagliptin; oral
5.4
21.8
67
133
A10BB12
ATC
glimepiride; oral
4.0
21.8
91
248
I20.09
ICD-10 Finland
Unstable angina
5.0
21.1
70
152
81
HP
Angiography of the heart and coronary arteries
4.6
20.9
76
181
AN4
HP
Balloon angioplasty and drug eluding stent
7.5
20.9
50
71
A10AE05
ATC
insulin detemir; parenteral
4.9
20.9
70
153
C07AB02
ATC
metoprolol; systemic
2.5
20.6
185
859
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
5.2
20.5
65
134
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
20.1
147
606
N03AX16
ATC
pregabalin; oral
2.4
19.5
201
1000
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
6.1
19.3
53
92
I20.01
ICD-10 Finland
Unstable angina
7.7
19.3
45
62
C09AA02
ATC
enalapril; systemic
2.4
19.0
183
879
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
19.0
141
586
A02BC02
ATC
pantoprazole; systemic
2.0
18.8
484
3554
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
18.3
148
645
N02BE01
ATC
paracetamol; systemic, rectal
2.4
18.1
628
5186
I50.9
ICD-10 Finland
Heart failure, unspecified
2.8
18.1
125
493
E86
ICD-10 Finland
Volume depletion
33.8
18.0
23
7
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
4.7
18.0
62
140
L28
ICPC
Limited function/disability (L)
2.7
17.5
134
564
I25.2
ICD-10 Finland
Old myocardial infarction
3.9
17.3
74
206
C10AA04
ATC
fluvastatin; oral
3.4
17.0
87
280
B04AC04
ATC
NA
26.3
17.0
23
9
N03AX12
ATC
gabapentin; oral
2.6
16.9
134
575
M10.0
ICD-10 Finland
Idiopathic gout
5.4
16.8
51
100
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
16.7
260
1540
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.3
16.6
87
285
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.1
16.6
95
332
A10BX01
ATC
guar gum; systemic
5.3
16.6
51
102
C03DA01
ATC
spironolactone; oral
3.0
16.5
99
358
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
16.3
229
1297
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
16.3
115
459
I20.90
ICD-10 Finland
Angina pectoris, unspecified
5.9
16.1
45
80
N02AX02
ATC
tramadol; systemic, rectal
1.9
16.0
329
2164
177
Kela drug reimbursment
Insulin glargine 300 U / ml
10.1
15.8
31
32
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
15.7
147
687
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
15.6
166
828
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
4.3
15.6
58
142
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
5.1
15.5
49
101
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
15.3
81
268
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
15.1
72
219
A10BK01
ATC
dapagliflozin; oral
4.3
15.0
56
138
A10BB01
ATC
glibenclamide; oral
4.5
14.8
53
125
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
14.8
167
854
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
13.6
14.8
25
19
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.4
14.8
44
85
C08CA13
ATC
lercanidipine; oral
2.6
14.7
119
515
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
7.8
14.5
33
44
R42
ICD-10 Finland
Dizziness and giddiness
2.2
14.4
163
834
R06.0
ICD-10 Finland
Dyspnoea
2.1
14.4
187
1017
160
Kela drug reimbursment
exenatide
7.6
14.3
33
45
E78.49
ICD-10 Finland
Other hyperlipidaemia
27.8
14.3
19
7
H02AB06
ATC
prednisolone; systemic
1.9
14.3
343
2352
C03AA03
ATC
hydrochlorothiazide; oral
3.1
14.2
81
282
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
12.3
14.2
25
21
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
4.8
14.1
47
103
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.0
13.9
225
1334
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
13.9
89
335
J01DB01
ATC
cefalexin; oral
2.0
13.8
596
4969
211
Kela drug reimbursment
Severe hereditary disorders of lipid metabolism (familial hypercholesterolaemia and type III dyslipoproteinemia)
76.6
13.6
15
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.1
13.6
54
141
B04AC02
ATC
NA
34.7
13.5
17
5
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.8
13.5
58
163
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
13.4
137
667
E87.6
ICD-10 Finland
Hypokalaemia
14.1
13.3
22
16
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
3.7
13.3
59
170
C10AA03
ATC
pravastatin; oral
3.5
13.3
64
197
I20.99
ICD-10 Finland
Angina pectoris, unspecified
3.4
13.3
65
203
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.7
13.2
45
101
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.5
13.2
112
495
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.3
13.1
49
121
R5140
NOMESCO Finland
Monitoring the use of the aid
2.7
13.1
97
398
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
6.8
12.9
32
49
N06AX21
ATC
duloxetine; oral
2.9
12.7
81
302
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
12.7
121
568
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
3.8
12.6
53
146
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
4.5
12.6
44
102
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
12.6
176
981
A10BX07
ATC
[U] liraglutide; parenteral
10.3
12.6
24
24
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.5
12.5
58
174
A10BG03
ATC
pioglitazone; oral
5.4
12.4
37
72
XF600
NOMESCO Finland
Bloodpressure measurement
3.3
12.2
62
199
SPAT1263
SPAT
Sampling
1.8
12.1
304
2081
I20.00
ICD-10 Finland
Unstable angina
5.7
12.1
34
62
N06AB04
ATC
citalopram; systemic
2.0
12.0
165
912
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.0
12.0
47
122
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.2
11.9
64
215
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.4
11.8
57
176
EBA00
NOMESCO Finland
Extraction of tooth
1.8
11.6
243
1560
WX110
NOMESCO Finland
Local anesthesy
1.7
11.6
482
3824
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
7.3
11.6
27
38
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
11.5
60
197
L17
ICPC
Foot/toe symptom/complaint
1.9
11.5
183
1067
E66.9
ICD-10 Finland
Obesity, unspecified
5.7
11.4
32
58
S97
ICPC
Chronic ulcer skin
3.4
11.4
55
170
C02AC05
ATC
moxonidine; oral
4.0
11.4
45
118
N05CF01
ATC
zopiclone; oral
1.8
11.3
229
1457
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
11.2
84
348
A10BD07
ATC
metformin and sitagliptin; systemic
3.6
11.1
49
141
P01AB01
ATC
metronidazole; oral, rectal
1.8
10.9
262
1756
Z71.8
ICD-10 Finland
Other specified counselling
2.0
10.9
160
903
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
10.8
286
1972
A28
ICPC
Limited function/disability NOS
2.2
10.8
118
588
SPAT1254
SPAT
Administration of medicine
2.2
10.8
112
547
N03AX09
ATC
lamotrigine; oral
4.3
10.8
39
94
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
2.1
10.8
130
675
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.9
10.7
26
39
M79.6
ICD-10 Finland
Pain in limb
1.8
10.7
240
1569
K85
ICD-10 Finland
Acute pancreatitis
5.6
10.7
30
55
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.0
10.6
61
214
J01MA02
ATC
ciprofloxacin; systemic
1.7
10.6
290
2016
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.7
10.6
364
2705
E66.8
ICD-10 Finland
Other obesity
3.9
10.6
43
116
E78.40
ICD-10 Finland
Familial combined hyperlipidaemia
111.5
10.4
11
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.6
10.4
78
321
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
5.9
10.4
28
49
SPAT1310
SPAT
Counselling related to known health issue
1.8
10.3
225
1457
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
10.2
122
633
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
10.2
257
1741
A46
ICD-10 Finland
Erysipelas
2.1
10.1
114
578
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
10.1
113
568
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.8
9.9
32
69
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
6.4
9.9
25
40
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
9.9
126
671
J01FF01
ATC
clindamycin; systemic
1.8
9.8
194
1214
C09CA06
ATC
candesartan; oral
1.9
9.8
152
871
XCK10
NOMESCO Finland
Photography of fundus of eye
2.4
9.8
83
366
N05BA04
ATC
oxazepam; oral
1.9
9.7
170
1019
N05AH04
ATC
quetiapine; oral
2.1
9.7
115
594
S18
ICPC
Laceration/cut
1.7
9.7
301
2155
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
9.7
95
450
C09CA01
ATC
losartan; oral
1.9
9.7
174
1053
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
3.6
9.6
43
126
SPAT1240
SPAT
Therapeutic discussion
2.6
9.6
71
292
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.2
9.5
50
166
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.1
9.5
117
612
K02.1
ICD-10 Finland
Caries of dentine
1.6
9.5
385
2954
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
9.4
195
1237
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
3.6
9.4
41
118
E87.2
ICD-10 Finland
Acidosis
+∞
9.4
9
*
N06AA09
ATC
amitriptyline; systemic
2.5
9.3
75
322
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.5
9.3
32
74
162
Kela drug reimbursment
liraglutide
9.7
9.3
18
19
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
9.2
192
1218
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
7.9
9.2
20
26
R55
ICD-10 Finland
Syncope and collapse
2.3
9.2
85
393
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
9.2
82
372
UJF32
NOMESCO Finland
Coloscopy
1.8
9.1
188
1186
FN1BT
NOMESCO Finland
Extensive endovascular dilatation of coronary (PTCA) arteries
6.0
9.1
24
41
82
HP
Single vessel balloon catheter extension
5.7
9.1
25
45
R53
ICD-10 Finland
Malaise and fatigue
1.9
9.1
135
762
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.6
9.1
380
2927
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
9.0
81
368
A02BC01
ATC
omeprazole; systemic
1.8
9.0
194
1242
E87.5
ICD-10 Finland
Hyperkalaemia
24.3
8.9
12
5
C08CA02
ATC
felodipine; oral
2.4
8.9
76
338
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
8.9
90
433
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
8.1
8.9
19
24
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.1
8.9
109
571
A02BC05
ATC
esomeprazole; systemic
1.6
8.9
277
1973
B01AC24
ATC
ticagrelor; oral
4.0
8.8
34
88
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
8.8
83
388
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
5.0
8.8
27
56
C09BA02
ATC
enalapril and diuretics; systemic
2.4
8.7
74
326
WX722
NOMESCO Finland
PEEP
3.3
8.7
42
132
N18.8
ICD-10 Finland
Other chronic renal failure
4.9
8.6
27
57
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
8.4
8.6
18
22
C10BA02
ATC
simvastatin and ezetimibe; oral, topical
8.4
8.6
18
22
I50.0
ICD-10 Finland
Congestive heart failure
2.7
8.6
59
233
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.6
8.6
61
244
B01AA03
ATC
warfarin; systemic
1.9
8.6
146
863
4019X
ICD-9 Finland
Essential hypertension, Unspecified
4.1
8.5
32
81
A06AD11
ATC
lactulose; oral
2.1
8.5
105
552
A10AE06
ATC
insulin degludec; parenteral
4.5
8.5
29
67
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
8.5
87
420
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.9
8.5
50
180
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
8.5
94
472
C10AC02
ATC
colestipol; oral
91.0
8.4
9
*
280
Kela drug reimbursment
Clopidogrel
8.0
8.4
18
23
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
8.0
8.4
18
23
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
8.4
171
1073
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.1
8.3
101
525
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.7
8.3
56
218
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
8.3
103
543
A02BA02
ATC
ranitidine; systemic
1.8
8.3
145
866
E0000UV
ATC
NA
1.6
8.2
251
1766
R02
ICPC
Shortness of breath/dyspnoea
2.2
8.2
84
407
N06AX11
ATC
mirtazapine; oral
1.7
8.2
210
1411
A10AB06
ATC
insulin glulisine; parenteral
7.7
8.2
18
24
C07AG02
ATC
carvedilol; oral
2.8
8.2
52
196
R03AC02
ATC
salbutamol; inhalant
1.6
8.2
339
2582
R60.0
ICD-10 Finland
Localized oedema
2.3
8.1
75
344
207
Kela drug reimbursment
Chronic arrhythmias
2.0
8.1
104
555
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.5
8.1
36
106
TK800
NOMESCO Finland
Hemodialysis
5.1
8.1
24
48
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.5
8.1
61
252
R11
ICD-10 Finland
Nausea and vomiting
2.7
8.1
55
216
XF402
NOMESCO Finland
ECG with work load test
2.2
8.0
82
396
A01
ICPC
Pain general/multiple sites
2.6
8.0
58
237
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.1
7.9
29
72
J01AA02
ATC
doxycycline; systemic
1.6
7.9
536
4584
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.1
7.9
90
456
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
7.9
63
269
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
7.9
466
3848
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
7.9
106
577
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
7.8
322
2439
H03AA01
ATC
levothyroxine sodium; systemic
1.8
7.8
133
784
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
7.8
57
234
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
7.8
89
453
SPAT1260
SPAT
Consultation of another employee
1.9
7.7
124
716
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
7.5
7.7
17
23
N06AX16
ATC
venlafaxine; oral
2.1
7.6
88
448
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
5.0
7.6
23
47
P99
ICPC
Psychological disorders other
4.7
7.6
24
52
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
7.6
85
427
WX892
NOMESCO Finland
Monitored bed care
2.6
7.6
55
224
K85.8
ICD-10 Finland
Other acute pancreatitis
10.2
7.6
14
14
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
4.2
7.6
27
66
N07BA03
ATC
varenicline; oral
2.9
7.5
45
164
WX872
NOMESCO Finland
Intensive care
2.8
7.5
45
165
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
7.4
197
1329
AN2
HP
Balloon angioplasty, including several vessels
4.0
7.4
28
72
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.4
7.4
21
40
J01DA01
ATC
[U] cefalexin; systemic
1.5
7.4
420
3415
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
7.4
116
664
XF404
NOMESCO Finland
Ambulatory ECG
2.3
7.3
70
327
R51.80
ICD-10 Finland
Headache
2.0
7.3
90
471
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
7.3
88
458
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
9.5
7.3
14
15
H3603, E113
ICD-10 Finland
NA
9.5
7.3
14
15
2721A
ICD-9 Finland
Disorders of lipoid metabolism, Pure hyperglyceridaemia[HYPERTRIGLYCERIDAEMIA FAMILIARIS (FHT)]
+∞
7.3
7
*
E78.3
ICD-10 Finland
Hyperchylomicronaemia
+∞
7.3
7
*
E78.21
ICD-10 Finland
Remnant hyperlipidemia
+∞
7.3
7
*
T82
ICPC
Obesity
4.2
7.2
26
64
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.7
7.2
30
84
PE1BT
NOMESCO Finland
Femoral artery extensive PTA
15.9
7.2
11
7
C10AA02
ATC
lovastatin; oral
3.3
7.2
35
111
SPAT1216
SPAT
Assessment of functional ability
1.9
7.2
106
593
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
7.2
50
199
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.2
330
2546
N05AX08
ATC
risperidone; systemic
2.4
7.2
62
277
M01AB05
ATC
diclofenac; systemic, rectal
1.5
7.2
456
3787
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.4
7.1
61
270
C07AB08
ATC
celiprolol; oral
4.0
7.1
27
70
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.2
7.1
71
339
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.2
7.1
36
118
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.0
7.1
90
478
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
7.1
56
241
K22
ICPC
Risk factor cardiovascular disease
2.7
7.0
45
171
A10BH02
ATC
vildagliptin; oral
4.5
7.0
23
52
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
7.0
48
189
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
3.5
7.0
30
87
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.3
7.0
24
57
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.7
6.9
28
77
N03AG01
ATC
valproic acid; systemic, rectal
2.6
6.9
48
191
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
6.9
62
281
FN2AB
NOMESCO Finland
Percutaneous transluminal coronary angioplasty (PTCA), drug-eluting balloon
6.8
6.8
16
24
H36.01
ICD-10 Finland
Diabetic maculopathy
5.7
6.8
18
32
B04AC01
ATC
NA
40.4
6.8
8
*
G63.2
ICD-10 Finland
Diabetic polyneuropathy
16.9
6.8
10
6
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
4.2
6.7
24
59
T89
ICPC
Diabetes insulin dependent
3.2
6.7
33
106
E66.0
ICD-10 Finland
Obesity due to excess calories
7.3
6.7
15
21
D01
ICPC
Abdominal pain/cramps general
2.2
6.7
68
329
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.6
6.7
28
80
A04
ICPC
Weakness/tiredness general
2.1
6.6
77
395
A10BG02
ATC
rosiglitazone; oral
6.0
6.6
17
29
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.3
6.6
59
270
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.6
113
667
SPAT1097
SPAT
Recording of ECG
1.9
6.6
106
612
WX290
NOMESCO Finland
Other blockade of nerve
1.5
6.5
274
2063
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
3.4
6.5
29
87
M01AB01
ATC
indometacin; systemic, rectal
2.2
6.5
63
300
N02AA05
ATC
oxycodone; systemic
1.9
6.5
102
586
SPAT1312
SPAT
General health counselling
1.6
6.5
210
1486
F34.1
ICD-10 Finland
Dysthymia
3.6
6.5
27
77
B01AF02
ATC
apixaban; oral
2.2
6.4
65
315
A11
ICPC
Chest pain NOS
2.4
6.4
54
238
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
6.4
51
218
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.7
6.4
42
164
SPAT1211
SPAT
Application of soft bandage
2.1
6.4
68
335
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
6.6
6.4
15
23
K92
ICPC
Atherosclerosis/periph vascular dis
6.6
6.4
15
23
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.5
6.4
48
201
Z72.0
ICD-10 Finland
Tobacco use
4.2
6.4
22
53
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.3
255
1901
SPAT1360
SPAT
Extensive global examination
2.3
6.3
57
263
B01AB05
ATC
enoxaparin; parenteral
1.6
6.3
199
1402
S29
ICPC
Skin symptom/complaint other
1.8
6.3
114
689
A10BX04
ATC
[U] exenatide; parenteral
7.1
6.2
14
20
N06AX12
ATC
bupropion; oral
2.7
6.2
40
152
R05
ICPC
Cough
1.7
6.2
140
899
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
6.2
120
737
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
6.2
45
186
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.5
6.2
268
2027
K04.4
ICD-10 Finland
Acute apical periodontitis of pulpal origin
2.2
6.2
61
293
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
6.4
6.2
15
24
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
5.4
6.2
17
32
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
5.4
6.2
17
32
N05BA12
ATC
alprazolam; oral
2.0
6.2
73
375
I95.1
ICD-10 Finland
Orthostatic hypotension
3.6
6.2
26
75
FN1CB
NOMESCO Finland
Coronary flow reserve measurement with pressure wire
4.7
6.1
19
41
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.8
6.1
36
131
N05BA01
ATC
diazepam; systemic, rectal
1.9
6.1
92
520
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
12.6
6.1
10
8
127
Kela drug reimbursment
Transplant complication
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERGLYCER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERGLYCER | 1.744 [1.49, 2.04] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 592 out of 1826 females with E4_HYPERGLYCER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERGLYCER | 1.701 [1.46, 1.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 2695 males with E4_HYPERGLYCER died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERGLYCER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.306% |
| 5 | 0.801% | 2.134% |
| 10 | 1.861% | 5.326% |
| 15 | 3.869% | 9.828% |
| 20 | 6.775% | 16.051% |
Relationships between endpoints
↥Index endpoint: E4_HYPERGLYCER – Pure hyperglyceridaemia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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