No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
593 |
4. Check minimum number of eventsNone |
593 |
5. Include endpointsNone |
593 |
6. Filter based on genotype QC (FinnGen only) |
593 |
Control definitions (FinnGen only)
- Control exclude
- E4_GLUCOPANCREAS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E16
- Name in latin
- Hypoglychaemia ex medicamento sine comate
Similar endpoints
↥List of similar endpoints to
Drug-induced hypoglycaemia without coma
based on the number of shared cases.
Similar with more cases:
- Other disorders of glucose regulation and pancreatic internal secretion
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4342 | 1947 | 2352 |
| Only index persons | 3451 | 1539 | 1912 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.07 |
| Only index persons | 0.07 | 0.06 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 67.85 | 72.85 | 63.76 |
| Only index persons | 67.13 | 71.38 | 63.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 593 | 248 | 345 |
| Unadjusted period prevalence (%) | 0.12 | 0.08 | 0.15 |
| Median age at first event (years) | 60.79 | 55.88 | 64.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 546
- Matched controls
- 5457
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
15526.0
323.0
496
*
103
Kela drug reimbursment
Diabetes, insulin-treated
78.2
304.6
514
930
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
48.5
287.5
371
228
A10AE04
ATC
insulin glargine; parenteral
45.8
284.9
376
251
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
44.4
265.1
345
203
215
Kela drug reimbursment
Diabetes, non-insulin-treated
22.3
217.9
423
729
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
49.3
197.8
241
86
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
41.1
194.8
249
109
A10AA02
ATC
NA
40.7
172.7
220
89
A10AE05
ATC
insulin detemir; parenteral
29.3
167.7
236
138
T89
ICPC
Diabetes insulin dependent
37.4
165.3
215
93
A10AA01
ATC
NA
58.5
164.3
192
50
H04AA01
ATC
glucagon; nasal, parenteral
53.3
145.4
173
47
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
44.2
145.1
180
60
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
58.0
137.6
161
39
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
42.5
133.5
167
56
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
+∞
128.3
118
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
55.9
128.2
151
37
A10AE06
ATC
insulin degludec; parenteral
35.5
109.7
143
54
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
8.4
108.2
316
769
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
15.6
94.3
164
146
XCK10
NOMESCO Finland
Photography of fundus of eye
10.7
93.9
203
285
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
76.1
93.8
105
17
E10
ICD-10 Finland
Type 1 diabetes mellitus
36.8
81.7
105
35
SPAT1262
SPAT
Handing over of treatment supplies
7.0
81.7
248
577
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
81.5
80.2
89
13
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
25.4
80.0
114
56
177
Kela drug reimbursment
Insulin glargine 300 U / ml
41.1
69.6
87
25
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
40.0
65.2
82
24
T90
ICPC
Diabetes non-insulin dependent
5.5
64.2
241
687
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
19.7
63.4
98
60
H3603, E103
ICD-10 Finland
NA
54.1
63.4
75
16
A10BA02
ATC
metformin; oral
4.9
60.9
270
911
A10BB12
ATC
glimepiride; oral
8.2
58.7
144
229
2510A
ICD-9 Finland
Other disorders of pancreatic internal secretion, Hypoglycaemic coma[HYPERINSULINAEMIA IATROGENEA SEU FACTITIA]
+∞
57.3
54
*
H3600, E103
ICD-10 Finland
NA
34.9
56.3
73
24
CKC12
NOMESCO Finland
Photocoagulation of retina
13.8
56.1
100
87
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
13.1
54.1
99
91
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
7.4
52.9
139
242
A10BB01
ATC
glibenclamide; oral
9.3
49.0
108
141
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.0
46.4
175
470
H36.00
ICD-10 Finland
Diabetic background retinopathy
25.3
46.1
65
29
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
58.5
45.5
53
10
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
18.5
44.8
70
43
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
41.7
42.8
53
14
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
42.2
40
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
38.2
41.2
52
15
H3601, E103
ICD-10 Finland
NA
37.3
40.2
51
15
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
69.8
39.7
45
7
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
16.8
39.0
63
42
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
14.9
38.3
65
49
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
32.2
38.1
50
17
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
48.9
37.5
45
10
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.6
37.4
226
904
H43.1
ICD-10 Finland
Vitreous haemorrhage
15.5
36.6
61
44
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.3
35.6
72
79
C03CA01
ATC
furosemide; systemic
3.2
34.7
253
1149
H36.01
ICD-10 Finland
Diabetic maculopathy
23.3
34.2
49
23
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
9.7
31.7
66
76
E11
ICD-10 Finland
Type 2 diabetes mellitus
4.0
30.6
138
421
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
164.0
30.0
31
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
28.6
29.7
40
15
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.9
29.1
87
171
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.0
29.1
133
408
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
18.1
28.9
45
27
H3601, E113
ICD-10 Finland
NA
16.6
28.7
46
30
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
9.5
28.6
60
70
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
17.4
28.6
45
28
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.4
28.5
52
46
C09AA02
ATC
enalapril; systemic
3.4
28.4
169
642
S97
ICPC
Chronic ulcer skin
6.4
27.5
76
135
A10AA03
ATC
NA
17.4
26.7
42
26
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
11.1
26.6
51
50
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.7
26.6
131
426
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.1
26.5
61
83
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.2
25.8
108
303
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
10.5
25.8
51
53
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
30.1
25.7
34
12
A10AB06
ATC
insulin glulisine; parenteral
30.1
25.7
34
12
A46
ICD-10 Finland
Erysipelas
3.7
25.6
128
420
A10BH01
ATC
sitagliptin; oral
4.4
25.5
99
259
H3600, E113
ICD-10 Finland
NA
18.2
25.3
39
23
CKC10
NOMESCO Finland
Local photocoagulation of retina
13.2
24.5
43
35
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
24.1
145
546
CKC15
NOMESCO Finland
Panretinal photocoagulation
28.2
23.8
32
12
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
68.1
23.0
26
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
22.8
128
455
205
Kela drug reimbursment
Chronic hypertension
2.7
22.6
209
1032
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.4
22.6
47
54
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.7
22.5
67
130
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
6.3
22.4
61
106
C10AA01
ATC
simvastatin; oral
2.5
22.1
275
1590
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
21.9
135
512
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.9
21.4
73
166
NHQ40
NOMESCO Finland
Amputation of toe
12.3
21.1
38
33
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
9.6
21.0
43
48
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.6
20.9
102
324
I10
ICD-10 Finland
Essential (primary) hypertension
2.4
20.7
329
2130
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
19.3
20.6
31
17
TPH07
NOMESCO Finland
Cathetrisation of artery
3.9
20.6
91
266
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
11.9
20.3
37
33
G63.2
ICD-10 Finland
Diabetic polyneuropathy
28.3
20.2
27
10
H3603, E113
ICD-10 Finland
NA
19.8
20.2
30
16
A11CC03
ATC
alfacalcidol; systemic
8.9
20.1
43
52
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
7.9
19.9
46
63
I50.9
ICD-10 Finland
Heart failure, unspecified
3.0
19.6
129
510
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.6
19.5
71
172
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
27.2
19.3
26
10
R11
ICD-10 Finland
Nausea and vomiting
4.0
19.1
80
222
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
10.9
18.9
36
35
171
Kela drug reimbursment
Degludekinsuliini
72.5
18.8
21
*
H3602, E103
ICD-10 Finland
NA
72.5
18.8
21
*
TK800
NOMESCO Finland
Hemodialysis
9.2
18.7
39
45
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.2
18.5
74
197
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
18.3
97
327
Z49.1
ICD-10 Finland
Extracorporeal dialysis
15.0
18.3
30
21
V03AE01
ATC
polystyrene sulfonate; oral
12.0
18.2
33
29
C02AC05
ATC
moxonidine; oral
5.7
18.1
53
101
C08CA01
ATC
amlodipine; oral
2.3
18.0
220
1222
C09AA05
ATC
ramipril; oral
2.5
18.0
168
814
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.7
17.9
147
663
E10.01
ICD-10 Finland
Insulin-dependent diabetes diabetic coma with hyperglycemia
98.3
17.7
19
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
98.3
17.7
19
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
17.5
147
670
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
21.8
17.4
25
12
A10BX01
ATC
guar gum; systemic
5.7
17.4
51
97
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.5
17.4
166
811
J01MA02
ATC
ciprofloxacin; systemic
2.2
17.1
242
1435
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
26.6
17.0
23
9
A09AA02
ATC
multienzymes (lipase, protease etc.)
12.6
17.0
30
25
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
16.8
178
916
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.1
16.6
53
112
A10BH05
ATC
linagliptin; oral
5.1
16.4
53
113
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
41.5
16.4
20
5
Z94.0
ICD-10 Finland
Kidney transplant status
17.4
16.2
25
15
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
16.1
99
369
A12AA04
ATC
calcium carbonate; oral
9.9
16.1
32
34
J01DA01
ATC
[U] cefalexin; systemic
2.2
16.1
354
2519
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.5
16.0
48
94
C10AA05
ATC
atorvastatin; oral
2.2
16.0
220
1278
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.8
15.9
114
470
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
61.9
15.8
18
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
15.8
92
330
A28
ICPC
Limited function/disability NOS
2.8
15.5
113
470
WX892
NOMESCO Finland
Monitored bed care
4.1
15.5
63
170
Z49.0
ICD-10 Finland
Preparatory care for dialysis
16.7
15.4
24
15
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
15.3
171
895
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
24.2
15.2
21
9
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
24.2
15.2
21
9
B01AC04
ATC
clopidogrel; oral
2.7
15.0
120
524
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
58.4
14.9
17
*
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
13.7
14.8
25
19
J01FF01
ATC
clindamycin; systemic
2.3
14.8
168
883
N18.8
ICD-10 Finland
Other chronic renal failure
6.1
14.7
40
70
F10.09
ICD-10 Finland
Alcohol intoxication UNS
8.6
14.5
31
38
E87.5
ICD-10 Finland
Hyperkalaemia
8.0
14.3
32
42
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.2
14.3
189
1062
R53
ICD-10 Finland
Malaise and fatigue
2.4
14.3
144
714
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
14.1
193
1103
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.3
13.9
52
130
ZXA05
NOMESCO Finland
Left side
2.3
13.9
153
791
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.4
13.7
140
696
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
9.2
13.6
28
32
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
18.8
13.5
20
11
S18
ICPC
Laceration/cut
2.0
13.4
224
1384
A41.9
ICD-10 Finland
Sepsis, unspecified
5.8
13.4
38
70
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.5
13.4
121
564
C01DA14
ATC
isosorbide mononitrate; oral
2.4
13.3
125
593
J01MA12
ATC
levofloxacin; systemic
2.4
13.3
127
609
ZXA00
NOMESCO Finland
Right side
2.2
13.3
162
874
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
13.3
238
1514
AA1AD
NOMESCO Finland
CT of head and brain
2.2
13.2
154
814
L04AA06
ATC
mycophenolic acid; systemic
10.4
13.1
25
25
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
12.9
112
511
A10BB07
ATC
glipizide; oral
7.8
12.8
29
39
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
6.0
12.8
35
62
127
Kela drug reimbursment
Transplant complication
10.4
12.6
24
24
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.8
12.5
42
94
XCK20
NOMESCO Finland
NA
25.0
12.5
17
7
C03DA01
ATC
spironolactone; oral
2.9
12.4
82
317
M65.3
ICD-10 Finland
Trigger finger
5.4
12.4
37
73
N06AB04
ATC
citalopram; systemic
2.3
12.4
130
653
E66.00
ICD-10 Finland
Metabolic syndrome
4.4
12.3
45
110
WZC30
NOMESCO Finland
Teaching
2.8
12.3
85
339
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.9
12.3
34
61
N30.0
ICD-10 Finland
Acute cystitis
2.7
12.2
88
360
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.6
12.2
42
97
N18.0
ICD-10 Finland
End-stage renal disease
11.4
12.1
22
20
Z49.2
ICD-10 Finland
Other dialysis
18.6
12.1
18
10
L84
ICD-10 Finland
Corns and callosities
5.2
11.8
36
73
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.2
11.8
147
796
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
11.7
130
668
T87
ICPC
Hypoglycaemia
30.8
11.7
15
5
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
10.4
11.6
22
22
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
4.1
11.6
45
117
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
11.5
71
264
N06AX21
ATC
duloxetine; oral
3.0
11.5
67
240
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
11.4
69
252
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.9
11.4
21
20
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
35.8
11.3
14
*
AN1
HP
Coronary angiography
2.6
11.3
85
356
N05AH04
ATC
quetiapine; oral
2.4
11.3
101
466
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
11.2
76
300
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
5.8
11.2
31
56
L28
ICPC
Limited function/disability (L)
2.4
11.1
103
484
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.6
11.1
88
381
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
6.9
11.1
27
41
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
11.0
92
410
N03AX16
ATC
pregabalin; oral
2.2
10.9
126
655
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
61.2
10.7
12
*
J01DB01
ATC
cefalexin; oral
2.0
10.4
431
3568
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
7.3
10.4
24
34
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
33.2
10.4
13
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
10.3
226
1508
MAA00
NOMESCO Finland
Amniocentesis
7.7
10.3
23
31
B03XA02
ATC
darbepoetin alfa; parenteral
6.1
10.3
27
46
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.0
10.2
40
105
ZX120
NOMESCO Finland
Intravenous
2.9
10.2
64
241
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.5
10.2
85
378
SPAT1229
SPAT
Assessment of need for aid
3.0
10.1
58
206
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
10.3
10.1
19
19
C09BA02
ATC
enalapril and diuretics; systemic
2.8
10.0
65
249
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.3
10.0
51
167
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
10.0
59
214
A10BG02
ATC
rosiglitazone; oral
7.9
10.0
22
29
N06AB03
ATC
fluoxetine; oral
2.7
10.0
69
276
N02AA05
ATC
oxycodone; systemic
2.3
9.9
97
466
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.9
9.8
18
17
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.6
9.8
77
330
I50.0
ICD-10 Finland
Congestive heart failure
2.8
9.8
67
264
ZXA10
NOMESCO Finland
Bilateral
2.2
9.8
115
602
N05CF01
ATC
zopiclone; oral
1.9
9.7
183
1149
B05DA
ATC
Isotonic solutions
13.7
9.7
16
12
CKD40
NOMESCO Finland
Endophotocoagulation of retina
7.0
9.7
23
34
SPAT1254
SPAT
Administration of medicine
2.3
9.6
100
494
RD210
NOMESCO Finland
NA
8.6
9.6
20
24
L89
ICD-10 Finland
Decubitus ulcer and pressure area
5.9
9.6
26
46
R4180
NOMESCO Finland
Podiatric therapy
11.7
9.6
17
15
R33
ICD-10 Finland
Retention of urine
2.8
9.6
63
243
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
9.5
45
139
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.1
9.5
36
92
N03AX12
ATC
gabapentin; oral
2.3
9.5
90
424
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
9.5
56
203
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
9.4
101
506
E16.10
ICD-10 Finland
Hyperinsulinism
101.7
9.4
10
*
E87.2
ICD-10 Finland
Acidosis
30.6
9.4
12
*
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
30.6
9.4
12
*
2510B
ICD-9 Finland
Other disorders of pancreatic internal secretion, Hypoglycaemic coma[COMA HYPOGLYCAEMICUM]
+∞
9.4
9
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
9.4
9
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.5
9.4
43
130
137
Kela drug reimbursment
Uraemia requiring dialysis
10.9
9.3
17
16
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.9
9.3
38
104
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.0
9.2
54
195
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.6
9.2
40
116
A10BH02
ATC
vildagliptin; oral
6.4
9.2
23
37
N06AA09
ATC
amitriptyline; systemic
2.8
9.2
60
230
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
11.7
9.1
16
14
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.8
9.1
57
215
XF600
NOMESCO Finland
Bloodpressure measurement
3.2
9.0
46
151
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
9.0
186
1204
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
19.0
9.0
13
7
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
9.0
144
849
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.9
9.0
167
1041
NH2AA
NOMESCO Finland
Heel X-ray examination
24.5
8.9
12
5
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
8.9
84
395
CK2S4
SPAT
NA
12.8
8.9
15
12
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.6
8.9
65
266
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
8.8
59
231
E86
ICD-10 Finland
Volume depletion
5.0
8.8
27
56
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
8.8
81
378
B05DB
ATC
Hypertonic solutions
14.3
8.7
14
10
A10BJ06
ATC
semaglutide; parenteral
4.8
8.7
28
61
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.0
8.7
51
184
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
5.4
8.7
25
48
S91.3
ICD-10 Finland
Open wound of other parts of foot
5.4
8.7
25
48
M14.6*A52.1
ICD-10 Finland
Charcot's or tabetic arthropathy
50.8
8.7
10
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
8.6
76
347
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
8.6
137
805
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
8.4
8.6
18
22
L17
ICPC
Foot/toe symptom/complaint
2.0
8.6
130
748
C02EA02
ATC
NA
3.2
8.6
44
145
N05BA01
ATC
diazepam; systemic, rectal
2.3
8.6
82
388
C07AB07
ATC
bisoprolol; oral
1.7
8.5
251
1804
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
7.5
8.5
19
26
CL2L4
NOMESCO Finland
Wide-field fundus photography for diabetic retinopathy screening
28.0
8.5
11
*
R41.0
ICD-10 Finland
Disorientation, unspecified
4.2
8.5
31
77
N19
ICD-10 Finland
Unspecified kidney failure
4.0
8.5
33
87
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.6
8.5
28
63
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
13.0
8.4
14
11
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
13.0
8.4
14
11
C08CA02
ATC
felodipine; oral
2.6
8.4
63
264
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
6.0
8.4
22
38
371
Kela drug reimbursment
Degludekinsuliini
+∞
8.4
8
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
11.0
8.3
15
14
ACC51
NOMESCO Finland
Release of median nerve
3.2
8.3
43
143
F10.24
ICD-10 Finland
Alcohol depence active use
7.3
8.3
19
27
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
8.3
251
1817
SPAT1054
SPAT
Examination of peripheral nervous system
5.5
8.2
23
43
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
6.2
8.2
21
35
AN4
HP
Balloon angioplasty and drug eluding stent
3.8
8.2
33
90
S01.0
ICD-10 Finland
Open wound of scalp
2.8
8.2
52
198
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.8
8.2
52
198
N05BA04
ATC
oxazepam; oral
1.9
8.2
138
826
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.1
8.2
44
151
C07AG02
ATC
carvedilol; oral
3.0
8.1
46
161
N05AF03
ATC
chlorprothixene; systemic
5.2
8.1
24
48
M14.6
ICD-10 Finland
Neuropathic arthropathy
33.9
8.1
10
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
33.9
8.1
10
*
N05CD07
ATC
temazepam; oral
2.3
8.1
81
391
UJF32
NOMESCO Finland
Coloscopy
1.9
8.1
133
792
D01AC02
ATC
miconazole; topical
2.7
8.1
54
211
SPAT1263
SPAT
Sampling
1.7
8.1
224
1578
C10AA07
ATC
rosuvastatin; oral
2.0
8.1
121
695
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
22.4
8.0
11
5
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
22.4
8.0
11
5
C08CA13
ATC
lercanidipine; oral
2.3
8.0
74
345
K08.3
ICD-10 Finland
Retained dental root
2.9
7.9
49
181
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.7
7.9
33
93
C03AA03
ATC
hydrochlorothiazide; oral
2.6
7.9
58
241
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
8.6
7.9
16
19
C10AX09
ATC
ezetimibe; oral
2.5
7.8
62
266
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
11.0
7.8
14
13
S91.1
ICD-10 Finland
Open wound of toe(s) without damage to nail
7.1
7.8
18
26
Z71.8
ICD-10 Finland
Other specified counselling
1.9
7.8
126
743
WX140
NOMESCO Finland
Parabulbar anesthesy
3.8
7.8
32
89
A10BK03
ATC
empagliflozin; oral
3.0
7.8
44
154
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
7.8
137
833
N06AX16
ATC
venlafaxine; oral
2.3
7.8
72
335
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
6.5
7.8
19
30
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
7.8
103
563
F10.20
ICD-10 Finland
Alcohol dependence currently independent
5.7
7.7
21
38
H3603, E107
ICD-10 Finland
NA
45.6
7.7
9
*
T89
ICD-10 Finland
NA
45.6
7.7
9
*
I95.9
ICD-10 Finland
Hypotension, unspecified
7.6
7.7
17
23
SPAT1240
SPAT
Therapeutic discussion
2.4
7.7
64
282
WX213
NOMESCO Finland
Lower leg blockade
18.7
7.6
11
6
F54
ICD-10 Finland
Psychological and behavioural factors associated with disorders or diseases classified elsewhere
25.4
7.6
10
*
E11.01
ICD-10 Finland
Non-insulin dependent diabetes diabetic coma with hyperglycaemia
25.4
7.6
10
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.9
7.6
30
81
A06AD11
ATC
lactulose; oral
2.0
7.6
100
547
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.9
7.5
44
159
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.6
7.5
54
219
E000001
ATC
NA
1.9
7.5
110
627
J01EA01
ATC
trimethoprim; systemic
1.8
7.4
137
841
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.3
7.4
15
487
E16.9
ICD-10 Finland
Disorder of pancreatic internal secretion, unspecified
81.2
7.4
8
*
H26.2
ICD-10 Finland
Complicated cataract
7.8
7.4
16
21
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
7.4
99
543
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
13.6
7.4
12
9
N03AX09
ATC
lamotrigine; oral
3.4
7.4
34
104
SPAT1301
SPAT
No procedures
1.7
7.4
170
1122
C10AA04
ATC
fluvastatin; oral
2.6
7.4
54
223
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.0
7.4
28
73
A10BD07
ATC
metformin and sitagliptin; systemic
3.6
7.3
32
94
R4110
NOMESCO Finland
Physiotherapy
1.8
7.3
133
812
E13.1
ICD-10 Finland
Other specified diabetes mellitus, with ketoacidosis
+∞
7.3
7
*
E932D
ICD-9 Finland
Hormones and synthetic substitutes[INSULIINI]
+∞
7.3
7
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.4
7.3
18
29
K59.0
ICD-10 Finland
Constipation
3.1
7.3
39
134
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.5
7.3
32
95
WX002
NOMESCO Finland
Sedation and analgesia
2.0
7.2
99
547
SPAT1139
SPAT
Nutrition survey
3.9
7.2
28
75
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
6.7
7.2
17
26
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.2
91
487
RJ521
NOMESCO Finland
NA
20.3
7.2
10
5
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.7
7.2
49
195
C09CA01
ATC
losartan; oral
1.9
7.1
119
709
V03AE02
ATC
sevelamer; oral
12.2
7.1
12
10
M04AA01
ATC
allopurinol; systemic
2.1
7.1
83
430
RJ411
NOMESCO Finland
NA
10.2
7.1
13
13
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
7.1
96
529
F10.25
ICD-10 Finland
Alcohol dependence continuous use
7.1
7.0
16
23
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.6
7.0
30
87
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
5.3
7.0
20
39
N05AX08
ATC
risperidone; systemic
2.4
7.0
57
249
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
7.0
90
485
N05AA02
ATC
levomepromazine; systemic
3.5
7.0
31
93
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
7.7
6.9
15
20
L03.9
ICD-10 Finland
Cellulitis, unspecified
5.1
6.9
20
40
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.6
6.8
22
49
EBA00
NOMESCO Finland
Extraction of tooth
1.7
6.8
164
1095
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
11.1
6.8
12
11
N03AG01
ATC
valproic acid; systemic, rectal
2.8
6.8
43
162
2500X
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,NUD]
9.5
6.8
13
14
P15
ICPC
Chronic alcohol abuse
4.4
6.8
23
54
2504A
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYP II]
40.6
6.8
8
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.8
223
1622
WX110
NOMESCO Finland
Local anesthesy
1.6
6.8
337
2732
2507A
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI II]
22.8
6.7
9
*
K92.0
ICD-10 Finland
Haematemesis
4.5
6.6
22
51
K05.31
ICD-10 Finland
Periodontitis pronounced
2.4
6.6
52
225
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
4.6
6.5
21
47
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
6.5
157
1048
I25.2
ICD-10 Finland
Old myocardial infarction
2.5
6.5
51
220
M86.8
ICD-10 Finland
Other osteomyelitis
70.6
6.4
7
*
E13.6
ICD-10 Finland
Other specified diabetes mellitus, with other specified complications
70.6
6.4
7
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
6.4
139
895
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
6.4
43
171
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
14.5
6.4
10
7
CL2S4
SPAT
NA
14.5
6.4
10
7
N06AX11
ATC
mirtazapine; oral
1.7
6.4
153
1017
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
3.0
6.4
34
117
WX872
NOMESCO Finland
Intensive care
3.0
6.4
34
117
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
6.4
63
302
D10
ICPC
Vomiting
3.0
6.4
36
126
OAB50
SPAT
NA
6.7
6.4
15
23
160
Kela drug reimbursment
exenatide
5.3
6.4
18
35
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
8.3
6.4
13
16
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
6.1
6.3
16
27
NGQ20
NOMESCO Finland
Amputation of lower leg
11.2
6.3
11
10
E13.7
ICD-10 Finland
Other specified diabetes mellitus, with multiple complications
18.3
6.3
9
5
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
6.3
36
129
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
3.0
6.3
33
113
K86.0
ICD-10 Finland
Alcohol-induced chronic pancreatitis
+∞
6.3
6
*
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
4.0
6.3
23
59
QWC00
NOMESCO Finland
Reoperation for superficial infection in surgery of skin
27.0
6.2
8
*
2505B
ICD-9 Finland
Diabetes mellitus, Diabetes with ophthalmic manifestations[NEUROPATHIA DIABETICA,TYYPPI I]
27.0
6.2
8
*
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
6.2
115
706
XCD20
NOMESCO Finland
Photoangiography of eye
4.6
6.2
20
45
201
Kela drug reimbursment
Chronic cardiac insufficiency
2.7
6.2
40
154
J02AC01
ATC
fluconazole; systemic
1.7
6.2
170
1170
N05AH03
ATC
olanzapine; systemic
2.7
6.2
40
155
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.8
6.2
19
41
3AC01
NOMESCO Finland
NA
7.8
6.2
13
17
N03AF01
ATC
carbamazepine; oral, rectal
2.8
6.1
37
139
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
6.1
169
1169
K90.0
ICD-10 Finland
Coeliac disease
4.2
6.1
21
51
H16.0
ICD-10 Finland
Corneal ulcer
3.0
6.1
32
110
SPAT1255
SPAT
Intravenous administration of medicine
2.7
6.0
40
158
A41.8
ICD-10 Finland
Other specified sepsis
5.7
6.0
16
29
S20
ICPC
Corn/callosity
4.6
6.0
19
42
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
3.5
6.0
26
77
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPODRUG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPODRUG | 3.179 [2.59, 3.9] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.425 |
During the follow-up period (1.1.1998 — 31.12.2019), 810 out of 1499 females with E4_HYPODRUG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPODRUG | 4.327 [3.31, 5.66] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 853 out of 1762 males with E4_HYPODRUG died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPODRUG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.291% | 0.724% |
| 5 | 1.778% | 4.777% |
| 10 | 4.592% | 11.687% |
| 15 | 9.211% | 21.543% |
| 20 | 16.109% | 34.332% |
Relationships between endpoints
↥Index endpoint: E4_HYPODRUG – Drug-induced hypoglycaemia without coma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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