No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
510 |
4. Check minimum number of eventsNone |
510 |
5. Include endpointsNone |
510 |
6. Filter based on genotype QC (FinnGen only) |
510 |
Control definitions (FinnGen only)
- Control exclude
- G6_CPETAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified paralytic syndromes
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5694 | 2528 | 3080 |
| Only index persons | 4141 | 1913 | 2228 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.07 | 0.09 |
| Only index persons | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 46.76 | 48.42 | 45.00 |
| Only index persons | 38.07 | 42.26 | 34.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 510 | 274 | 236 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | 47.69 | 43.62 | 52.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 455
- Matched controls
- 4551
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G83.9
ICD-10 Finland
Paralytic syndrome, unspecified
3160.7
205.4
183
*
G83.8
ICD-10 Finland
Other specified paralytic syndromes
+∞
124.9
114
*
34408
ICD-8 Finland
Other cerebral paralysis, Alia definita
+∞
84.0
78
*
34409
ICD-8 Finland
Other cerebral paralysis, Unspecified
+∞
65.2
61
*
AA1AD
NOMESCO Finland
CT of head and brain
3.8
32.8
175
638
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.9
32.5
72
94
G81.9
ICD-10 Finland
Hemiplegia, unspecified
346.8
32.3
32
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.3
32.2
92
175
3449X
ICD-9 Finland
Other paralytic syndromes, Paralysis, unspecified
+∞
30.6
29
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
263.8
24.9
25
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.9
23.8
112
354
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.9
21.4
55
89
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.7
21.2
77
189
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.9
20.5
44
54
N03AX14
ATC
levetiracetam; systemic
11.1
19.5
37
36
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.8
19.0
35
32
R51.80
ICD-10 Finland
Headache
3.3
19.0
107
384
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
18.6
71
183
N03AX12
ATC
gabapentin; oral
3.2
18.5
110
410
L28
ICPC
Limited function/disability (L)
3.3
18.3
104
374
N03AF02
ATC
oxcarbazepine; oral
9.5
18.0
37
42
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.5
17.8
66
165
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.4
17.5
94
323
A28
ICPC
Limited function/disability NOS
3.2
17.2
100
365
XF400
NOMESCO Finland
ECG with 12 standard connections
3.2
17.0
102
380
N03AG01
ATC
valproic acid; systemic, rectal
4.5
16.8
62
154
TKC20
NOMESCO Finland
Catheterisation of bladder
5.4
16.6
51
104
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.4
16.5
86
289
N03AX09
ATC
lamotrigine; oral
5.8
16.1
46
86
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.5
15.9
59
147
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
15.8
61
158
TAB00
NOMESCO Finland
Lumbar puncture
6.2
15.5
42
73
N03AF01
ATC
carbamazepine; oral, rectal
5.1
15.3
49
105
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
21.9
14.8
21
10
R4120
NOMESCO Finland
Occupational therapy
4.6
14.8
53
128
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.2
14.6
25
20
R4110
NOMESCO Finland
Physiotherapy
2.4
14.5
150
766
N05CD07
ATC
temazepam; oral
3.2
13.8
80
287
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.7
13.7
63
191
R42
ICD-10 Finland
Dizziness and giddiness
2.6
13.6
118
546
N02AA05
ATC
oxycodone; systemic
3.0
13.4
85
326
N05AA02
ATC
levomepromazine; systemic
5.3
13.3
41
84
R53
ICD-10 Finland
Malaise and fatigue
2.5
13.3
119
562
N05BA01
ATC
diazepam; systemic, rectal
3.0
13.1
82
311
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.7
13.1
45
104
XA800
NOMESCO Finland
Neuropsychological investigation
5.5
12.9
38
74
N05AX08
ATC
risperidone; systemic
3.6
12.7
59
180
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
12.5
181
1073
R06.0
ICD-10 Finland
Dyspnoea
2.4
12.4
124
614
N03AX16
ATC
pregabalin; oral
2.3
12.4
132
678
N05AH04
ATC
quetiapine; oral
2.6
12.3
101
452
N06AX16
ATC
venlafaxine; oral
2.9
12.2
78
300
R20.2
ICD-10 Finland
Paraesthesia of skin
4.1
12.2
48
127
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
12.1
116
561
N18
ICPC
Paralysis/weakness
10.5
12.1
23
23
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.7
12.1
41
94
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
11.8
150
833
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.8
11.8
51
147
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
11.7
200
1259
N03AE01
ATC
clonazepam; systemic
4.3
11.7
43
107
G35
ICD-10 Finland
Multiple sclerosis
10.4
11.6
22
22
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
11.6
55
171
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
+∞
11.5
11
*
3141A
ICD-9 Finland
Hyperkinetic syndrome of childhood, Hyperkinesis with developmental delay
+∞
11.5
11
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
11.5
92
406
N99
ICPC
Neurological disease other
17.6
11.3
17
10
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
11.2
97
443
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.6
11.1
32
61
UKC02
NOMESCO Finland
Cystoscopy
2.6
11.0
89
393
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
8.1
11.0
24
31
N06AB04
ATC
citalopram; systemic
2.3
10.9
121
627
N06AX11
ATC
mirtazapine; oral
2.1
10.8
162
959
R11
ICD-10 Finland
Nausea and vomiting
3.2
10.8
57
193
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
22.1
10.7
15
7
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.6
10.7
87
384
SPAT1229
SPAT
Assessment of need for aid
3.4
10.7
53
171
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
61.5
10.7
12
*
R52.2
ICD-10 Finland
Other chronic pain
5.5
10.7
31
60
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.2
10.5
56
190
F44.4
ICD-10 Finland
Dissociative motor disorders
+∞
10.5
10
*
78151
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Aphasia
+∞
10.5
10
*
M03BX01
ATC
baclofen; systemic
9.9
10.4
20
21
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
10.3
70
279
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
10.3
84
372
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.8
10.3
67
261
L17
ICPC
Foot/toe symptom/complaint
2.2
10.1
125
677
R33
ICD-10 Finland
Retention of urine
3.6
10.1
46
139
N05AF03
ATC
chlorprothixene; systemic
5.7
10.0
28
52
N88
ICPC
Epilepsy
20.6
9.9
14
7
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
9.7
75
321
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.7
9.7
27
50
A06AD11
ATC
lactulose; oral
2.5
9.6
78
343
WX892
NOMESCO Finland
Monitored bed care
3.5
9.6
45
139
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.7
9.5
41
119
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
+∞
9.4
9
*
34400
ICD-8 Finland
Other cerebral paralysis, Hemiplegia NUD
+∞
9.4
9
*
M79.6
ICD-10 Finland
Pain in limb
1.9
9.4
171
1079
N02BE01
ATC
paracetamol; systemic, rectal
2.2
9.3
384
3243
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.2
9.3
28
57
183
Kela drug reimbursment
Lamotrigin and topiramate
14.0
9.2
15
11
N02AX02
ATC
tramadol; systemic, rectal
1.9
9.1
195
1299
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
9.1
107
566
G83.4
ICD-10 Finland
Cauda equina syndrome
37.5
9.1
11
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
9.1
138
813
A02BC02
ATC
pantoprazole; systemic
1.8
9.0
285
2166
R60.0
ICD-10 Finland
Localized oedema
2.8
8.9
59
231
A29
ICPC
General symptom/complaint other
2.7
8.9
62
250
WX110
NOMESCO Finland
Local anesthesy
1.9
8.9
309
2419
C03CA01
ATC
furosemide; systemic
2.0
8.9
130
753
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
8.8
113
620
G44.2
ICD-10 Finland
Tension-type headache
2.5
8.7
70
307
N05AH03
ATC
olanzapine; systemic
3.3
8.7
43
139
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
8.7
86
417
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.6
8.6
38
112
N28
ICPC
Limited function/disability (N)
9.2
8.6
17
19
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.8
8.6
35
97
M54.1
ICD-10 Finland
Radiculopathy
4.7
8.5
28
63
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.3
8.4
30
73
K90
ICPC
Stroke/cerebrovascular accident
6.0
8.4
22
38
SPAT1216
SPAT
Assessment of functional ability
2.4
8.4
76
356
34099
ICD-8 Finland
Multiple sclerosis
+∞
8.4
8
*
N05BA04
ATC
oxazepam; oral
2.0
8.3
116
654
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
8.3
67
292
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
6.7
8.3
20
31
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
8.2
127
745
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
8.2
85
421
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
8.4
8.2
17
21
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
8.1
72
332
S06.0
ICD-10 Finland
Concussion
2.6
8.1
61
258
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.7
8.1
22
40
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
8.0
7.9
17
22
G43.9
ICD-10 Finland
Migraine, unspecified
3.6
7.9
35
104
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.9
175
1166
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.6
7.8
19
30
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
5.7
7.8
21
38
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
45.8
7.7
9
*
F60.7
ICD-10 Finland
Dependent personality disorder
25.5
7.6
10
*
N03AX18
ATC
lacosamide; systemic
25.5
7.6
10
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.3
7.6
37
119
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.3
7.5
36
114
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
7.5
100
554
C07AB07
ATC
bisoprolol; oral
1.7
7.4
195
1365
109
Kela drug reimbursment
Multiple sclerosis
9.6
7.3
14
15
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
9.6
7.3
14
15
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
6.4
7.3
18
29
G82.2
ICD-10 Finland
Paraplegia, unspecified
+∞
7.3
7
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
7.2
83
429
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
7.5
7.2
16
22
N06AB03
ATC
fluoxetine; oral
2.4
7.2
61
274
G40.89
ICD-10 Finland
Other epilepsy
30.5
7.2
9
*
A04
ICPC
Weakness/tiredness general
2.4
7.2
65
301
H53.2
ICD-10 Finland
Diplopia
4.5
7.1
24
56
P29
ICPC
Psychological sympt/compl other
3.5
7.1
32
97
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.0
7.1
40
141
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.0
7.1
27
71
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.7
7.1
46
180
SPAT1254
SPAT
Administration of medicine
2.2
7.0
74
372
R52.9
ICD-10 Finland
Pain, unspecified
2.7
6.9
47
185
R55
ICD-10 Finland
Syncope and collapse
2.5
6.9
54
234
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.1
6.9
25
63
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
6.8
54
236
N06AA09
ATC
amitriptyline; systemic
2.6
6.8
50
209
3459X
ICD-9 Finland
Epilepsy, unspecified
40.7
6.8
8
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
6.7
53
232
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
6.7
81
429
U05
ICPC
Urination problems other
3.4
6.7
31
97
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.9
6.6
25
66
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.6
6.6
21
47
XKD00
NOMESCO Finland
Uroflowmetry
2.2
6.5
70
353
30920
ICD-8 Finland
Mental disorders not specified as psychotic associated with physical conditions, Brain trauma
70.8
6.4
7
*
XCK00
NOMESCO Finland
Perimetry
3.1
6.4
34
117
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
14.6
6.4
10
7
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
6.4
51
223
U07
ICPC
Urine symptom/complaint other
3.2
6.4
32
106
C09AA05
ATC
ramipril; oral
1.9
6.4
107
643
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.5
6.4
28
84
A02BC03
ATC
lansoprazole; oral
1.8
6.3
129
825
G40
ICD-10 Finland
Epilepsy
9.4
6.3
12
13
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
6.3
6
*
34308
ICD-8 Finland
Cerebral spastic infantile paralysis, Alia definita
+∞
6.3
6
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
6.3
6
*
3001A
ICD-9 Finland
Neurotic disorders, Hysteria[KONVERSIOHÄIRIÖ]
+∞
6.3
6
*
38990
ICD-8 Finland
Other deafness, Partialis uni-sive bilateralis
+∞
6.3
6
*
3430A
ICD-9 Finland
Infantile cerebral palsy, Diplegic
+∞
6.3
6
*
34300
ICD-8 Finland
Cerebral spastic infantile paralysis, Hemiplegia spastica
+∞
6.3
6
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
6.2
82
449
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
27.1
6.2
8
*
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
27.1
6.2
8
*
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
27.1
6.2
8
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
4.6
6.2
20
45
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
6.2
47
200
S18
ICPC
Laceration/cut
1.7
6.2
175
1233
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
6.2
33
114
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.4
6.2
21
50
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.2
132
857
M89.0
ICD-10 Finland
Algoneurodystrophy
12.7
6.1
10
8
G41.9
ICD-10 Finland
Status epilepticus, unspecified
12.7
6.1
10
8
T90.5
ICD-10 Finland
Sequelae of intracranial injury
8.8
6.1
12
14
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
6.1
121
767
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
10.2
6.1
11
11
N86
ICPC
Multiple sclerosis
10.2
6.1
11
11
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
5.7
6.0
16
29
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.0
118
745
XF600
NOMESCO Finland
Bloodpressure measurement
2.9
6.0
35
128
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
264
1159
3.65
45.77
3.9
2.0
243.5
224.8
u/l
0.10
254
1098
109
351
3.68
28.82
3.6
2.4
28.5
46.7
u/l
0.76
92
288
299
1727
2.77
27.67
9.1
5.9
1.2
1.2
mmol/l
0.94
282
1579
312
1918
2.61
24.25
9.0
6.5
1.2
1.2
mmol/l
0.68
282
1619
140
597
2.85
22.67
4.9
2.9
2.0
2.3
e6/l
0.24
76
309
115
440
3.08
22.65
3.5
2.9
7.9
7.9
umol/l
0.00
99
383
46
91
5.46
22.57
1.3
1.2
464.4
415.8
mg/l
0.57
40
86
42
79
5.70
21.74
1.2
1.2
3.7
3.8
mmol/l
0.19
35
72
274
1655
2.42
21.08
5.7
4.5
35.6
35.9
g/l
0.39
259
1556
345
2316
2.51
20.85
8.6
4.5
6.6
6.7
mmol/l
0.85
335
2164
24
26
9.64
20.12
1.1
1.0
—
—
—
0
0
139
626
2.68
19.98
4.5
2.7
0.6
1.1
e6/l
1.78
74
338
152
726
2.56
19.29
5.0
3.3
457.6
318.0
ng/l
0.17
112
554
364
2562
2.47
18.90
7.8
4.2
4824.4
1802.9
e6/l
—
7
48
132
601
2.61
18.40
4.2
3.2
0.8
0.8
mmol/l
0.66
126
566
235
1390
2.28
18.19
6.0
3.1
—
—
—
0
0
102
415
2.82
17.67
2.3
1.7
—
—
—
0
0
39
83
5.01
17.58
1.3
1.3
347.3
223.1
e6/l
0.24
25
70
39
83
5.01
17.58
1.3
1.2
4.9
5.7
e6/l
0.07
23
67
192
1059
2.30
17.39
5.9
3.0
0.3
0.4
e6/l
0.22
149
782
89
340
2.96
17.29
9.2
7.4
1.7
1.4
mmol/l
0.90
83
326
307
2065
2.22
16.88
8.2
5.9
9.8
11.3
umol/l
2.11
298
1953
109
470
2.68
16.83
17.3
22.6
1.4
1.3
inr
0.32
13
58
101
419
2.76
16.81
2.4
1.7
—
—
—
0
0
130
613
2.50
16.68
2.5
1.8
—
—
—
0
0
227
1369
2.19
16.28
5.0
3.1
31.7
31.5
u/l
0.02
215
1307
100
420
2.72
16.22
7.4
7.6
0.6
1.1
mmol/l
0.46
83
340
218
1304
2.17
15.86
3.8
3.3
2.3
2.4
mmol/l
0.13
196
1161
26
42
6.47
15.61
1.1
1.0
—
—
—
0
0
26
43
6.32
15.27
1.1
1.0
—
—
—
0
0
25
40
6.52
15.15
1.1
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
16
16
10.29
14.09
1.1
1.1
—
—
—
0
0
15
15
10.27
13.18
1.0
1.0
—
—
—
0
0
33
78
4.45
13.11
3.8
2.8
31.4
38.5
umol/l
0.62
28
65
42
120
3.72
12.95
3.0
2.5
9.9
10.2
g/l
0.10
37
101
157
890
2.10
12.57
2.7
1.8
0.9
1.2
mg/l
0.75
130
676
81
347
2.59
12.46
8.1
3.9
6.0
5.8
kpa
0.91
76
336
105
508
2.34
12.41
5.3
5.4
1.0
1.0
mmol/l
0.12
98
467
77
323
2.63
12.36
5.2
6.2
8.8
9.1
mmol/l
0.13
70
305
17
22
7.96
12.35
1.0
1.0
1.2
1.1
u/l
—
7
11
44
134
3.50
12.34
3.0
2.4
7.0
7.5
g/l
1.04
36
99
44
134
3.50
12.34
3.0
2.4
—
—
—
0
0
44
134
3.50
12.34
3.0
2.4
3.9
3.7
g/l
0.21
35
94
80
343
2.58
12.28
8.2
3.9
1.9
1.8
mmol/l
0.04
67
269
321
2364
1.97
11.92
14.5
8.9
4.0
4.1
e9/l
0.46
283
2076
42
128
3.49
11.77
3.1
2.5
2.9
3.2
g/l
1.48
35
96
31
77
4.22
11.56
1.6
1.3
—
—
—
0
0
31
77
4.22
11.56
1.6
1.3
—
—
—
0
0
231
1537
1.92
11.51
2.3
1.9
85.1
95.4
pmol/l
2.99
142
831
161
951
2.01
11.35
2.4
2.1
3.0
3.1
mg/l
0.44
132
813
389
3089
2.09
11.34
11.8
7.2
85.7
77.7
u/l
1.56
376
2905
240
1638
1.88
10.88
2.7
2.3
71.8
75.9
nmol/l
1.23
217
1484
55
207
2.86
10.84
2.1
1.7
—
—
—
0
0
68
287
2.58
10.74
2.0
1.5
—
—
—
0
0
28
71
4.11
10.17
1.1
1.1
—
—
—
0
0
272
1963
1.83
10.04
10.0
5.7
28.1
28.0
%
0.03
262
1842
192
1251
1.86
9.83
4.1
2.4
51.1
55.4
u/l
1.18
185
1163
13
16
8.31
9.77
3.3
2.3
164.0
76.7
umol/l
—
8
9
270
1956
1.81
9.73
4.9
3.5
0.0
0.0
estimate
0.00
39
376
221
1521
1.80
9.35
5.9
3.5
291.9
39.1
ng/l
0.46
156
984
34
105
3.40
9.34
1.1
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
100
3.46
9.33
10.7
2.7
0.3
0.3
u/ml
1.04
16
51
147
894
1.91
9.24
1.7
1.6
19.3
20.6
nmol/l
0.52
128
759
15
25
6.15
8.70
1.3
2.4
—
—
—
0
0
150
934
1.86
8.69
3.1
2.1
—
—
—
0
0
110
619
1.99
8.63
2.3
2.3
13.5
13.5
umol/l
0.00
103
571
167
1088
1.80
8.28
3.7
3.1
1005.5
1374.5
ng/l
1.12
146
910
58
257
2.42
8.24
3.7
3.9
1.6
1.9
mmol/l
0.18
44
193
264
1965
1.71
8.12
6.7
4.7
0.0
0.0
estimate
0.50
42
366
266
1988
1.71
8.02
5.1
3.5
0.0
0.0
estimate
0.50
40
353
51
216
2.51
7.98
1.7
1.4
—
—
—
0
0
65
312
2.24
7.69
2.4
2.3
7.0
7.2
ug/l
0.03
54
282
12
18
6.80
7.63
2.3
5.3
107.1
94.4
%
0.57
12
18
248
1841
1.68
7.50
4.3
3.9
—
—
—
0
0
23
65
3.66
7.22
1.3
1.3
2.2
5.3
u/ml
—
5
23
137
876
1.77
7.08
5.7
3.8
1.0
1.0
kg/l
0.55
29
113
93
533
1.91
6.82
2.4
2.3
24.4
22.7
%
0.51
83
458
115
707
1.81
6.76
3.4
2.8
2.5
2.4
mmol/l
0.41
106
627
10
14
7.27
6.72
1.1
1.0
—
—
—
0
0
33
123
2.80
6.64
1.3
1.3
—
—
—
0
0
23
69
3.44
6.63
1.3
1.3
4.3
4.6
u/ml
0.06
13
31
359
3001
1.66
6.30
5.1
4.0
13.9
11.1
mm/h
2.36
337
2771
68
360
2.03
6.25
2.6
2.3
0.2
0.2
g/l
0.31
68
339
95
570
1.82
6.00
2.4
2.3
2.3
2.4
g/l
0.05
90
523
361
3061
1.61
5.59
4.9
3.9
14.6
14.7
pmol/l
0.22
335
2809
35
149
2.45
5.45
1.5
1.6
445.9
286.4
mu/l
0.99
30
135
29
113
2.66
5.39
1.4
1.4
246.9
307.5
ug/g
0.79
18
69
8
6
13.52
5.09
1.8
1.8
22.3
13.4
umol/l
—
8
6
54
289
1.97
4.82
3.5
3.9
76.1
82.0
ng/l
0.31
48
257
109
721
1.65
4.81
1.9
1.7
1031.9
1171.7
nmol/l
1.03
91
553
35
160
2.27
4.68
1.8
2.4
1.1
1.5
g/l
1.88
29
143
452
4134
1.82
4.49
28.4
13.1
20.0
22.3
mg/l
1.04
412
3250
36
171
2.19
4.40
4.6
4.5
25.2
25.1
mmol/l
0.13
31
163
12
31
3.94
4.28
1.2
1.2
—
—
—
0
0
19
67
2.91
4.27
2.4
2.5
15.1
15.8
%
—
7
33
414
3716
1.61
4.22
6.1
4.6
1.9
2.2
mu/l
0.42
391
3417
87
565
1.65
4.10
3.7
1.9
1.6
1.5
%
1.15
79
505
14
42
3.40
4.07
2.1
1.8
89.2
89.3
%
0.02
14
42
12
33
3.70
3.94
17.1
19.7
1238.6
1620.2
nmol/l
0.72
12
33
41
215
1.99
3.90
4.2
3.0
0.2
0.1
e6/l
0.80
41
206
22
90
2.51
3.77
1.2
1.4
—
—
—
0
0
326
2817
1.44
3.70
4.9
3.0
63.6
44.9
u/l
1.86
311
2662
222
1792
1.42
3.70
3.2
2.7
110.4
122.1
ug/l
0.40
206
1666
16
56
2.92
3.66
1.3
1.4
—
—
—
0
0
16
56
2.92
3.66
1.3
1.4
—
—
—
0
0
16
56
2.92
3.66
1.3
1.4
—
—
—
0
0
23
98
2.41
3.63
1.2
1.6
—
—
—
0
0
21
86
2.50
3.59
1.3
1.6
24054.9
14612.2
e6/l
—
10
64
16
57
2.87
3.55
1.3
1.4
—
—
—
0
0
9
17
5.37
3.52
3.8
2.6
666.2
739.5
u/ml
—
9
17
8
13
6.23
3.51
1.1
1.1
—
—
—
0
0
62
387
1.69
3.40
2.6
1.9
358.5
380.2
nmol/l
0.34
57
357
134
1005
1.45
3.26
3.2
2.5
3082.7
5935.6
umol/l
0.44
118
887
418
3825
1.51
3.23
24.3
12.0
85.8
83.4
ml/min/173m2
1.30
360
3140
15
55
2.78
3.18
1.2
1.4
—
—
—
0
0
15
55
2.78
3.18
1.3
1.1
—
—
—
0
0
22
98
2.30
3.17
1.6
1.6
—
—
—
0
0
22
99
2.28
3.10
5.7
3.6
34.2
122.7
mg/l
0.79
22
82
22
99
2.28
3.10
5.7
3.6
33.4
29.4
mg/l
0.15
22
82
15
56
2.73
3.08
1.3
1.4
—
—
—
0
0
21
94
2.29
3.00
2.8
1.5
—
—
—
0
0
43
254
1.76
2.88
1.8
3.4
4.3
4.6
pmol/l
1.01
35
221
23
110
2.14
2.83
1.5
1.5
12.9
9.5
u/l
0.40
17
93
315
2772
1.36
2.80
3.2
3.2
—
—
—
0
0
117
890
1.41
2.60
1.3
1.3
0.7
1.4
u/ml
1.42
21
237
134
1050
1.37
2.49
5.6
3.7
0.0
0.0
estimate
0.80
40
365
8
21
3.85
2.47
1.0
1.3
—
—
—
0
0
8
21
3.85
2.47
1.0
1.3
—
—
—
0
0
9
27
3.37
2.40
2.2
1.6
—
—
—
0
0
8
22
3.68
2.37
1.4
1.2
—
—
—
0
0
187
1553
1.32
2.35
5.2
3.6
—
—
—
0
0
106
807
1.40
2.33
1.5
1.8
96471015.1
7310367.5
pmol/l
0.44
85
684
26
141
1.89
2.32
4.0
2.1
7697.1
3778.1
u/l
—
8
56
10
35
2.89
2.31
1.1
1.0
—
—
—
0
0
10
35
2.89
2.31
1.1
1.7
—
—
—
0
0
10
35
2.89
2.31
1.1
1.7
—
—
—
0
0
10
35
2.89
2.31
1.1
1.7
—
—
—
0
0
15
66
2.31
2.26
1.1
1.1
1.4
113.9
iu/ml
—
5
19
5
9
5.60
2.22
1.4
1.2
—
—
—
0
0
12
49
2.48
2.12
1.2
1.7
—
—
—
0
0
8
25
3.23
2.10
1.9
2.5
—
—
—
0
0
402
3741
1.35
2.07
6.1
5.5
39.9
39.8
mmol/mol
0.08
382
3511
19
97
2.00
2.03
1.3
1.6
—
—
—
0
0
10
38
2.66
2.02
1.3
1.3
—
—
—
0
0
7
21
3.36
1.97
1.1
1.8
—
—
—
0
0
7
21
3.36
1.97
1.1
1.8
—
—
—
0
0
7
21
3.36
1.97
1.1
1.8
—
—
—
0
0
7
21
3.36
1.97
1.1
1.8
—
—
—
0
0
415
3895
1.35
1.90
5.2
4.3
6.0
5.9
mmol/l
0.34
387
3583
43
286
1.55
1.89
4.0
2.7
60.4
70.6
ml/min/173m2
1.15
16
116
373
3453
1.30
1.86
34.0
15.9
14.0
13.6
%
3.66
368
3393
24
399
0.58
1.85
1.7
1.7
—
—
—
0
0
12
53
2.29
1.82
1.1
1.4
—
—
—
0
0
10
41
2.47
1.76
1.2
1.8
—
—
—
0
0
7
24
2.94
1.73
1.9
1.6
—
—
—
0
0
5
13
3.87
1.72
1.0
1.0
—
—
—
0
0
5
13
3.87
1.72
1.0
1.0
—
—
—
0
0
43
293
1.51
1.71
1.2
1.2
235.7
171.3
iu/ml
0.30
16
119
18
97
1.89
1.68
3.9
2.3
12.7
12.3
mg/l
0.09
18
89
54
388
1.44
1.66
5.5
3.2
—
—
—
0
0
6
19
3.18
1.66
1.0
1.3
—
—
—
0
0
6
19
3.18
1.66
1.0
1.3
—
—
—
0
0
7
25
2.82
1.65
1.1
1.1
—
—
—
0
0
27
166
1.66
1.65
3.0
2.2
36.3
39.9
u/l
0.36
22
151
5
14
3.60
1.62
1.4
1.4
—
—
—
0
0
15
77
1.98
1.60
1.8
2.1
132.9
129.5
g/l
—
10
56
6
20
3.02
1.58
1.2
3.2
54.5
66.5
nmol/l
—
6
20
9
37
2.46
1.48
1.2
1.2
—
—
—
0
0
9
38
2.39
1.46
1.0
1.2
—
68.0
—
0
5
13
66
2.00
1.44
2.2
3.3
—
996.7
—
0
7
5
16
3.15
1.44
1.2
1.0
—
—
—
0
0
6
22
2.75
1.44
1.0
1.0
—
—
—
0
0
5
120
0.41
1.39
1.8
1.5
—
—
—
0
0
29
192
1.54
1.35
2.1
1.6
—
—
—
0
0
132
1122
1.24
1.29
4.3
4.1
7.2
10.0
mg/mmol
0.51
93
727
23
146
1.60
1.28
2.6
1.8
—
—
—
0
0
11
56
1.99
1.23
1.5
1.3
0.4
0.5
nmol/l
0.96
11
51
14
78
1.82
1.22
1.7
1.2
—
—
—
0
0
5
19
2.65
1.22
2.0
2.5
—
—
—
0
0
5
19
2.65
1.22
2.0
2.5
—
—
—
0
0
6
26
2.32
1.19
1.0
1.0
—
—
—
0
0
14
79
1.79
1.18
1.5
1.4
—
—
—
0
0
34
242
1.43
1.15
2.4
1.7
—
—
—
0
0
24
160
1.52
1.11
2.9
2.0
—
—
—
0
0
452
4371
1.30
1.09
16.6
9.7
27.0
26.9
u/l
0.03
441
4231
7
32
2.20
1.08
1.0
1.3
—
—
—
0
0
13
74
1.78
1.07
1.6
1.2
393.9
240.5
u/ml
—
8
39
7
35
2.01
1.00
1.4
1.2
—
—
—
0
0
7
35
2.01
1.00
1.4
1.2
—
—
—
0
0
7
36
1.96
0.97
1.4
1.2
—
—
—
0
0
7
36
1.96
0.97
1.4
1.2
—
—
—
0
0
7
36
1.96
0.97
1.4
1.2
—
—
—
0
0
18
117
1.56
0.95
1.2
1.1
—
—
—
0
0
16
101
1.60
0.94
1.1
1.3
—
—
—
0
0
6
30
2.01
0.87
1.3
1.7
—
—
—
0
0
20
137
1.48
0.85
1.5
1.9
33.5
36.2
nmol/l
0.25
20
130
8
46
1.75
0.83
1.1
1.5
—
—
—
0
0
5
97
0.51
0.79
1.2
1.6
—
—
—
0
0
28
209
1.36
0.77
1.4
1.4
29.9
26.0
iu/l
0.26
22
180
9
55
1.65
0.74
1.0
1.2
—
—
—
0
0
9
55
1.65
0.74
1.4
1.6
—
—
—
0
0
9
55
1.65
0.74
1.2
1.1
—
—
—
0
0
11
68
1.63
0.72
1.2
1.6
—
—
—
0
0
9
57
1.59
0.71
1.0
1.4
—
—
—
0
0
9
58
1.56
0.70
1.1
1.4
—
—
—
0
0
19
135
1.42
0.70
1.3
1.7
—
—
—
0
0
18
127
1.43
0.69
1.2
1.1
—
—
—
0
0
18
128
1.42
0.66
1.2
1.1
—
—
—
0
0
6
35
1.72
0.58
3.2
2.8
—
—
—
0
0
54
459
1.20
0.57
8.7
6.5
—
—
—
0
0
27
212
1.29
0.56
1.3
1.3
—
—
—
0
0
10
65
1.55
0.56
1.5
1.6
—
—
—
0
0
73
639
1.17
0.56
1.3
1.3
41.5
14.1
u/ml
0.30
22
260
78
687
1.16
0.55
1.4
1.3
27.4
33.7
iu/ml
0.23
33
226
16
116
1.39
0.55
1.3
1.3
—
—
—
0
0
6
38
1.59
0.54
2.2
2.7
2.7
7.0
nmol/l
—
6
38
6
39
1.54
0.53
1.0
1.5
—
—
—
0
0
6
40
1.51
0.51
3.7
4.0
—
—
—
0
0
13
92
1.42
0.51
1.5
1.9
—
—
—
0
0
6
41
1.47
0.50
1.5
1.8
16.0
17.1
ug/l
—
6
41
7
45
1.56
0.49
1.3
1.6
—
—
—
0
0
7
46
1.53
0.48
1.4
1.7
—
—
—
0
0
10
68
1.48
0.47
2.2
1.5
—
—
—
0
0
13
175
0.74
0.45
1.3
1.5
—
—
—
0
0
5
33
1.52
0.41
3.2
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
32.9
—
0
15
0
19
0.00
0.39
0.0
2.2
—
—
—
0
0
19
151
1.27
0.39
2.4
3.3
225.4
1273.4
u/ml
0.58
13
129
391
3822
1.10
0.38
31.1
13.8
39.0
40.4
%
2.21
290
2884
10
72
1.40
0.37
2.4
3.3
39.8
56.8
%
—
10
72
9
71
1.27
0.36
1.0
1.1
—
—
—
0
0
6
42
1.43
0.35
1.0
1.2
—
—
—
0
0
15
121
1.25
0.28
2.0
2.9
—
—
—
0
0
84
785
1.08
0.25
1.5
1.5
—
—
—
0
0
44
398
1.12
0.25
2.5
4.3
11.3
39.6
ug/l
0.74
33
328
11
137
0.80
0.24
1.4
2.3
—
—
—
0
0
395
3893
1.06
0.22
4.4
3.8
1.4
1.3
mmol/l
2.60
374
3609
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
0.4
—
0
9
6
53
1.13
0.18
1.0
1.0
—
—
—
0
0
7
63
1.11
0.17
1.3
1.5
—
—
—
0
0
7
88
0.79
0.14
1.3
1.2
—
—
—
0
0
45
477
0.94
0.12
4.8
4.3
31.5
31.3
%
0.04
34
330
19
209
0.91
0.11
1.1
1.0
—
—
—
0
0
5
45
1.11
0.10
1.6
1.2
—
—
—
0
0
105
1022
1.03
0.09
1.9
1.7
1.7
1.4
mmol/l
1.25
92
864
6
71
0.84
0.07
2.0
1.7
—
—
—
0
0
59
610
0.96
0.07
1.3
1.4
—
—
—
0
0
409
4113
0.97
0.07
5.5
4.6
2.7
2.8
mmol/l
1.38
391
3815
9
85
1.06
0.07
1.0
1.2
—
1.2
—
0
7
400
4023
0.97
0.07
5.0
4.2
1.4
1.4
mmol/l
3.08
382
3742
52
502
1.04
0.07
2.2
2.0
—
—
—
0
0
14
128
1.10
0.06
1.5
1.6
0.0
0.0
iu/ml
—
5
28
12
132
0.91
0.06
1.3
1.4
—
—
—
0
0
462
4603
1.04
0.06
38.9
19.3
133.2
136.6
g/l
5.09
456
4544
70
717
0.97
0.05
2.5
2.7
0.9
0.8
ug/l
0.16
53
436
99
976
1.02
0.03
3.4
4.0
23.5
21.4
%
0.36
38
420
22
212
1.04
0.02
3.0
2.6
80.4
46.3
u/ml
0.29
22
201
124
1250
0.99
0.02
4.0
4.4
2.4
2.4
ug/l
0.01
112
1124
405
4043
1.01
0.01
5.0
4.3
4.5
4.7
mmol/l
1.70
387
3785
11
115
0.96
0.00
1.3
1.3
—
28.8
—
0
6
46
456
1.01
0.00
2.2
1.9
—
—
—
0
0
18
182
0.99
0.00
1.8
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.1
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
56.0
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint G6_PARALOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PARALOTHUNS | 2.863 [2.26, 3.63] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 320 out of 1060 females with G6_PARALOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PARALOTHUNS | 2.83 [2.28, 3.52] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 1080 males with G6_PARALOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_PARALOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.461% |
| 5 | 1.319% | 3.017% |
| 10 | 3.301% | 7.971% |
| 15 | 6.249% | 14.537% |
| 20 | 10.48% | 24.181% |
Relationships between endpoints
↥Index endpoint: G6_PARALOTHUNS – Other and unspecified paralytic syndromes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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