retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
860 |
4. Check minimum number of eventsNone |
860 |
5. Include endpointsNone |
860 |
6. Filter based on genotype QC (FinnGen only) |
841 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H33
- Name in latin
- Retinoschisis et cystae retinales
Similar endpoints
↥List of similar endpoints to
Retinoschisis and retinal cysts
based on the number of shared cases.
Similar with more cases:
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5538 | 2706 | 2804 |
| Only index persons | 5192 | 2588 | 2604 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 62.82 | 63.54 | 62.17 |
| Only index persons | 62.55 | 63.27 | 61.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 841 | 406 | 435 |
| Unadjusted period prevalence (%) | 0.17 | 0.14 | 0.20 |
| Median age at first event (years) | 63.77 | 62.25 | 65.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 860
- Matched controls
- 8600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
307.7
824
*
CKC12
NOMESCO Finland
Photocoagulation of retina
519.2
307.7
324
10
H33.0
ICD-10 Finland
Retinal detachment with retinal break
1890.3
162.9
153
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
51.8
115.9
67
14
H33.3
ICD-10 Finland
Retinal breaks without detachment
1205.7
111.1
106
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.3
105.0
175
291
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
56.4
93.3
53
10
CKC10
NOMESCO Finland
Local photocoagulation of retina
467.6
86.7
85
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.2
86.0
168
325
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.2
82.9
119
166
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
41.4
77.2
47
12
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
17.7
73.5
61
37
H43.1
ICD-10 Finland
Vitreous haemorrhage
20.0
65.3
51
27
WX140
NOMESCO Finland
Parabulbar anesthesy
11.0
65.2
72
71
H43.8
ICD-10 Finland
Other disorders of vitreous body
4.6
61.7
169
433
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
97.9
50.5
55
6
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
45.2
43
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
460.5
44.6
44
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.4
43.1
190
668
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
33.6
32
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
66.1
33.3
38
6
H35.4
ICD-10 Finland
Peripheral retinal degeneration
117.9
31.9
34
*
H26.4
ICD-10 Finland
After-cataract
3.3
30.5
130
442
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
29.9
192
820
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.3
29.7
362
2073
Q14.10
ICD-10 Finland
Congenital retinoschis
+∞
29.3
28
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
28.3
432
2697
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
27.1
110
362
XCK10
NOMESCO Finland
Photography of fundus of eye
3.2
25.6
109
369
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
257.2
24.8
25
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
24.8
344
2041
XCH00
NOMESCO Finland
Eye pressure measurement
4.3
24.1
64
157
H34.8
ICD-10 Finland
Other retinal vascular occlusions
89.3
23.8
26
*
H33.5
ICD-10 Finland
Other retinal detachments
34.5
23.5
30
9
3611A
ICD-9 Finland
Retinal detachments and defects, Retinoschisis and retinal cysts
+∞
23.0
22
*
37603
ICD-8 Finland
Detachment of retina, Retinoschisis
+∞
22.0
21
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
20.9
20
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
102.3
18.6
20
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
194.1
18.6
19
*
XCK00
NOMESCO Finland
Perimetry
3.3
17.8
71
230
S01ED01
ATC
timolol; ophthalmic
4.1
16.9
47
119
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
16.7
16
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
16.7
16
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
61.2
15.8
18
*
S01ED51
ATC
timolol, combinations; ophthalmic
2.7
14.8
85
338
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
14.6
14
*
H3600, E113,
ICD-10 Finland
+∞
14.6
14
*
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
14.6
14
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
152.5
14.5
15
*
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
14.2
69
251
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
17.9
13.9
21
12
H35.36
ICD-10 Finland
Macular cyst
+∞
13.6
13
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
12.9
268
1741
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.5
12.9
44
129
H52.1
ICD-10 Finland
Myopia
4.1
12.7
35
88
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
12.5
12
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
131.9
12.5
13
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
11.5
11
*
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
11.5
11
*
H3601, E113,
ICD-10 Finland
+∞
11.5
11
*
H26.2
ICD-10 Finland
Complicated cataract
9.8
11.3
22
23
ZXA10
NOMESCO Finland
Bilateral
1.9
10.8
168
994
S01BC03
ATC
diclofenac; ophthalmic
4.7
10.8
25
55
H35.37
ICD-10 Finland
Macular holes
111.3
10.4
11
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
10.4
10
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
10.4
10
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
10.4
10
*
H26.02
ICD-10 Finland
Presenil cataract
3.8
10.2
31
84
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
13.3
10.2
17
13
S01EA05
ATC
brimonidine; ophthalmic
3.6
10.0
33
95
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
101.1
9.4
10
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
+∞
9.4
9
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
9.1
359
2702
CKC15
NOMESCO Finland
Panretinal photocoagulation
37.1
9.0
11
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.9
8.7
118
665
H40.0
ICD-10 Finland
Glaucoma suspect
2.2
8.7
76
365
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
8.3
8
*
S01EE01
ATC
latanoprost; ophthalmic
2.3
8.1
63
289
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
8.0
62
283
UDC00
NOMESCO Finland
Ear microscopy
2.2
8.0
71
344
S01EC04
ATC
brinzolamide; ophthalmic
2.7
7.9
43
167
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.2
7.9
20
33
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.5
7.9
26
75
A10AA02, ,
ATC
3.9
7.7
22
57
SPAT1263
SPAT
Sampling
1.5
7.7
337
2567
H36.01
ICD-10 Finland
Diabetic maculopathy
45.4
7.7
9
*
A98
ICPC
Health maint/preventive medicine
2.3
7.6
813
7585
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.7
7.5
171
1121
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
80.8
7.4
8
*
H25.8
ICD-10 Finland
Other senile cataract
1.9
7.3
99
557
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
7.3
7
*
A10AB01
ATC
insulin (human); parenteral
3.9
7.3
21
55
114
Kela drug reimbursment
Glaucoma
2.0
7.2
82
437
SPAT1312
SPAT
General health counselling
1.5
7.1
245
1767
H20.1
ICD-10 Finland
Chronic iridocyclitis
8.9
7.1
14
16
S01EC01
ATC
acetazolamide; systemic
3.9
7.0
20
52
S01EC03
ATC
dorzolamide; ophthalmic
4.4
7.0
17
39
S01BC05
ATC
ketorolac; ophthalmic
2.6
6.9
39
154
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
6.8
92
519
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.4
6.7
47
206
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
22.7
6.7
9
*
DFF00
NOMESCO Finland
Pure tone audiometry
1.8
6.3
96
561
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
6.3
6
*
H3603, E113,
ICD-10 Finland
+∞
6.3
6
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
6.3
6
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
6.3
6
*
R01AD12
ATC
fluticasone furoate; nasal
1.5
6.2
212
1520
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
6.2
305
2358
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
2.9
6.1
27
94
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
2.6
6.0
34
135
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
734
6453
1.94
10.70
5.2
4.7
1.97
2.19
mu/l
0.59
650
5817
786
7163
2.13
9.07
5.7
5.2
2.58
2.69
mmol/l
2.81
708
6528
622
5313
1.62
8.87
4.8
4.1
14.39
13.48
mm/h
0.67
574
4866
828
7734
2.90
8.69
24.7
23.1
39.53
39.89
%
0.69
760
7186
828
7738
2.88
8.61
24.8
23.0
243.29
244.47
e9/l
0.20
803
7517
828
7739
2.88
8.58
24.7
23.0
4.44
4.45
e12/l
0.25
799
7493
828
7740
2.88
8.56
24.9
23.1
134.59
134.50
g/l
0.06
816
7600
772
7020
1.97
8.51
5.3
4.9
5.93
6.02
mmol/l
1.27
692
6337
766
6956
1.93
8.35
5.1
4.6
1.45
1.45
mmol/l
0.02
690
6331
766
6999
1.86
7.56
5.2
4.7
4.48
4.58
mmol/l
1.80
693
6421
806
7507
2.17
7.31
12.5
10.9
26.07
25.84
u/l
0.12
773
7209
799
7428
2.07
7.11
19.4
18.4
139.81
139.67
mmol/l
0.86
780
7232
740
6730
1.71
6.94
4.6
4.1
1.27
1.30
mmol/l
0.69
658
6084
800
7454
2.05
6.86
19.5
18.5
3.99
3.99
mmol/l
0.23
782
7251
607
5302
1.49
6.51
4.4
3.8
15.17
14.97
pmol/l
1.10
538
4746
762
7014
1.76
6.48
16.5
15.7
23.06
26.28
mg/l
1.89
622
5630
440
3675
1.40
5.62
19.2
16.7
1.35
1.30
inr
0.49
136
1050
730
6703
1.59
5.56
6.5
6.0
39.83
40.11
mmol/mol
0.43
659
6152
447
3778
1.38
5.15
6.8
6.8
1.21
1.21
mmol/l
0.36
366
3211
351
2856
1.39
5.07
2.1
2.2
77.97
78.86
nmol/l
0.23
314
2515
627
5664
1.39
4.45
8.8
7.7
80.41
79.31
u/l
0.15
588
5310
355
2946
1.35
4.35
5.5
5.2
3.40
2.80
ug/l
0.30
311
2620
285
2308
1.35
4.04
2.1
2.2
229.92
238.57
u/l
0.04
265
2164
239
1896
1.36
3.84
1.5
1.5
19.76
20.34
nmol/l
0.28
202
1595
396
3388
1.31
3.77
6.4
5.9
27.74
26.97
%
0.66
366
3169
386
3291
1.31
3.77
5.4
4.8
35.26
35.05
g/l
0.30
350
3057
341
2866
1.31
3.66
3.0
2.7
138.97
150.28
ug/l
0.41
313
2604
389
3340
1.30
3.54
6.0
5.7
56.47
57.62
%
0.94
360
3125
94
638
1.53
3.51
4.6
3.6
1.23
1.23
mmol/l
0.02
87
559
719
6738
1.41
3.42
16.2
14.7
74.83
76.79
ml/min/173m2
1.70
599
5583
470
4155
1.29
3.35
9.2
9.0
4.07
4.17
e9/l
0.38
406
3631
347
2979
1.28
3.02
4.1
3.9
42.41
57.46
ng/l
0.48
270
2191
367
3183
1.27
2.91
2.1
2.0
100.13
94.53
pmol/l
1.36
189
1640
137
1040
1.38
2.86
2.4
2.5
21.15
22.40
%
0.64
114
880
143
1094
1.37
2.84
2.4
2.4
2.31
2.29
g/l
0.15
131
1013
126
949
1.38
2.76
5.5
4.6
32.26
32.48
%
0.08
92
630
153
1192
1.34
2.71
2.3
2.5
12.02
12.60
umol/l
0.57
141
1107
644
6000
1.29
2.70
18.9
18.7
15.42
15.24
%
0.28
634
5887
395
3478
1.25
2.69
5.7
6.1
1.21
1.21
mmol/l
0.49
359
3169
486
4392
1.25
2.58
4.5
4.9
6.63
6.75
mmol/l
0.81
457
4154
28
150
1.90
2.54
1.3
1.3
—
—
—
0
0
28
150
1.90
2.54
1.1
1.1
—
—
—
0
0
300
2575
1.25
2.52
3.6
3.5
2.34
2.35
mmol/l
0.88
261
2249
185
1497
1.30
2.50
1.6
1.6
1.02
1.25
mg/l
0.79
139
1185
52
336
1.58
2.46
4.5
3.3
4.38
4.47
pmol/l
0.32
46
291
280
2391
1.25
2.45
3.1
3.1
1328.26
1401.05
ng/l
0.12
238
2057
493
4477
1.24
2.45
3.2
3.2
49.89
53.47
u/l
0.44
448
4133
171
1376
1.30
2.41
1.2
1.2
1.26
1.90
u/ml
0.42
48
370
5
8
6.28
2.37
1.0
1.4
—
—
—
0
0
17
78
2.20
2.32
1.2
1.3
—
—
—
0
0
25
135
1.88
2.24
6.4
3.2
56.00
58.17
%
0.25
25
135
5
9
5.58
2.21
1.0
1.2
—
—
—
0
0
308
2685
1.23
2.19
4.5
4.0
—
—
—
0
0
270
2326
1.23
2.14
2.6
2.5
56.31
94.27
u/l
0.56
249
2143
227
1921
1.25
2.11
4.2
4.1
0.00
0.01
estimate
0.69
80
632
393
3522
1.21
2.10
4.2
3.8
0.00
0.00
estimate
0.50
80
641
24
131
1.86
2.10
6.0
3.0
3.99
4.42
e9/l
0.42
24
131
196
1633
1.26
2.09
1.7
1.7
72436290.10
8458512.77
pmol/l
0.42
156
1336
23
125
1.86
2.04
1.2
1.3
14.16
8.52
u/l
0.73
15
92
223
1892
1.24
2.02
2.4
2.1
3.05
3.08
mg/l
0.06
194
1584
11
44
2.52
2.01
1.1
1.2
—
—
—
0
0
431
3909
1.21
2.01
6.8
6.4
11.77
11.69
umol/l
0.04
410
3718
67
482
1.42
1.95
3.0
3.6
1.32
1.90
mmol/l
0.56
50
367
179
1495
1.25
1.86
1.8
1.7
1199.01
1189.44
nmol/l
0.04
125
1117
387
3497
1.19
1.82
4.2
3.8
0.00
0.00
estimate
0.74
92
709
265
2312
1.21
1.82
3.8
3.1
541.58
150.29
mg/l
0.58
175
1491
224
1926
1.22
1.78
1.7
1.6
1.36
1.36
mmol/l
0.00
176
1598
271
2376
1.21
1.76
4.9
4.5
22.54
21.19
%
0.85
143
1196
515
4788
1.19
1.71
4.9
4.6
4.17
3087.04
e6/l
—
6
72
384
3484
1.18
1.69
5.5
5.1
0.00
0.00
estimate
0.50
85
665
376
3407
1.18
1.68
2.6
2.7
—
—
—
0
0
6
19
3.17
1.66
1.5
1.6
—
—
—
0
0
227
1971
1.21
1.62
3.4
2.7
5492.04
7941.93
umol/l
0.35
192
1708
24
143
1.70
1.62
1.9
1.6
6.00
4.51
iu/l
—
10
42
103
819
1.29
1.61
4.0
3.4
—
—
—
0
0
5
15
3.35
1.52
1.0
1.2
—
—
—
0
0
70
533
1.34
1.50
2.1
2.1
15.36
12.45
nmol/l
1.93
58
474
149
1251
1.23
1.49
3.0
3.3
0.83
0.81
mmol/l
0.56
141
1170
7
28
2.51
1.45
1.0
1.6
—
—
—
0
0
7
28
2.51
1.45
1.1
1.2
—
—
—
0
0
276
2462
1.18
1.44
4.3
3.7
12.30
7.99
mg/mmol
0.63
173
1555
396
3649
1.16
1.35
2.5
2.5
—
—
—
0
0
89
713
1.28
1.34
2.4
2.5
6.02
6.56
ug/l
0.11
76
626
16
90
1.79
1.33
1.6
1.4
—
—
—
0
0
302
2732
1.16
1.31
3.3
3.3
—
—
—
0
0
51
379
1.37
1.30
1.2
1.2
139.05
202.35
u/ml
0.57
45
340
266
2385
1.17
1.29
3.5
3.1
7.57
7.52
mmol/l
0.05
222
1977
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
15
84
1.80
1.27
1.1
1.1
—
—
—
0
0
111
921
1.24
1.25
2.4
2.6
1.81
1.80
%
0.03
100
821
17
100
1.71
1.24
1.4
1.5
43.83
65.00
%
1.37
12
63
137
1165
1.21
1.22
1.4
1.3
32.86
38.81
iu/ml
0.13
32
385
5
19
2.64
1.21
1.2
2.0
—
—
—
0
0
5
19
2.64
1.21
1.0
1.2
—
—
—
0
0
5
19
2.64
1.21
1.0
1.2
—
—
—
0
0
8
38
2.12
1.18
1.6
2.7
—
—
—
0
0
12
64
1.89
1.18
1.1
1.1
—
—
—
0
0
8
39
2.06
1.15
1.3
1.4
4.69
6.89
u/l
—
8
29
103
857
1.23
1.15
1.3
1.4
—
—
—
0
0
5
21
2.39
1.09
1.6
1.3
114.80
108.93
%
—
5
15
85
697
1.24
1.09
3.3
3.0
156.87
222.94
ng/l
1.40
78
645
7
32
2.20
1.08
1.0
1.2
—
—
—
0
0
7
32
2.20
1.08
1.0
1.3
—
—
—
0
0
24
162
1.50
1.05
1.9
2.5
15.55
15.63
%
0.03
12
83
22
147
1.51
1.01
1.4
1.4
—
—
—
0
0
15
91
1.66
1.01
1.2
1.2
0.63
0.63
nmol/l
0.00
15
85
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
35
2.01
1.00
1.0
1.2
—
—
—
0
0
30
215
1.41
0.98
1.3
1.5
237.34
279.34
ug/g
0.57
14
128
105
892
1.20
0.97
3.9
4.1
229.42
252.12
u/l
1.28
100
836
136
1184
1.18
0.96
1.8
2.0
29.01
29.89
s
0.92
130
1146
201
1805
1.15
0.95
2.1
2.4
—
—
—
0
0
15
93
1.62
0.94
1.0
1.1
—
15.69
—
0
7
249
2274
1.13
0.91
3.0
3.3
29.90
33.42
u/l
1.68
233
2146
38
289
1.33
0.89
1.8
1.7
—
—
—
0
0
6
29
2.08
0.89
1.0
1.0
—
—
—
0
0
75
625
1.22
0.86
2.5
2.1
411.94
374.13
nmol/l
0.82
66
569
111
960
1.18
0.86
8.0
7.5
—
—
—
0
0
128
1123
1.16
0.84
1.4
1.3
3.75
13.64
u/ml
3.37
52
414
26
188
1.39
0.84
1.6
2.6
4.11
3.74
g/l
0.46
26
180
50
400
1.27
0.83
1.3
1.3
88.71
48.98
au/ml
—
7
25
17
114
1.50
0.80
1.4
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
144
1282
1.15
0.78
1.6
1.9
—
—
—
0
0
71
597
1.21
0.76
4.1
3.7
96.93
86.94
ng/l
0.44
60
522
15
99
1.52
0.76
1.1
1.6
—
—
—
0
0
5
26
1.93
0.70
1.2
1.3
—
—
—
0
0
30
231
1.31
0.68
1.5
1.6
—
—
—
0
0
18
127
1.43
0.68
1.1
1.6
—
—
—
0
0
5
94
0.53
0.67
1.0
1.0
—
—
—
0
0
13
86
1.52
0.66
1.1
1.2
8.49
7.27
mmol/l
—
7
72
28
215
1.31
0.65
2.7
1.9
—
—
—
0
0
15
103
1.46
0.65
1.1
1.2
302.80
286.82
u/ml
—
5
60
53
443
1.21
0.63
2.6
2.5
61.00
26.14
au/ml
—
5
25
22
164
1.35
0.63
2.7
2.3
123.65
126.37
g/l
0.20
17
122
83
724
1.16
0.62
3.6
3.7
2.08
2.09
mmol/l
0.01
72
599
16
113
1.42
0.61
1.1
1.6
—
—
—
0
0
160
1461
1.12
0.60
4.2
4.0
170.21
363.11
ng/l
1.53
135
1202
0
20
0.00
0.60
0.0
1.1
—
309.67
—
0
12
8
55
1.46
0.56
1.5
1.1
—
—
—
0
0
8
55
1.46
0.56
1.5
1.1
—
—
—
0
0
6
38
1.58
0.54
1.3
1.8
—
—
—
0
0
6
38
1.58
0.54
1.3
1.8
—
—
—
0
0
184
1705
1.10
0.53
3.2
3.2
0.66
0.78
ug/l
1.60
124
1170
15
108
1.40
0.53
1.1
1.2
—
—
—
0
0
6
39
1.54
0.53
1.3
1.2
127.02
155.51
pmol/l
—
6
39
14
100
1.41
0.52
1.1
1.6
—
—
—
0
0
20
153
1.31
0.50
1.1
1.3
3.79
3.70
mmol/l
0.16
20
143
46
390
1.19
0.50
1.4
1.8
1.52
1.58
g/l
0.16
38
338
18
235
0.76
0.50
1.1
1.2
—
—
—
0
0
64
559
1.16
0.49
1.4
1.6
—
—
—
0
0
21
163
1.30
0.48
1.2
1.3
39.66
31.05
iu/l
0.44
16
133
11
76
1.45
0.48
1.2
1.8
—
—
—
0
0
23
182
1.27
0.47
1.2
1.7
—
—
—
0
0
98
886
1.12
0.46
1.4
1.8
—
—
—
0
0
8
119
0.67
0.46
1.1
1.8
—
—
—
0
0
161
1498
1.09
0.44
3.3
3.2
2.44
2.46
mmol/l
1.16
144
1310
112
1025
1.11
0.43
6.6
5.4
1.02
1.02
mmol/l
0.03
107
935
8
56
1.43
0.42
1.5
1.1
—
—
—
0
0
8
56
1.43
0.42
1.5
1.1
—
—
—
0
0
8
56
1.43
0.42
1.4
1.8
—
—
—
0
0
8
56
1.43
0.42
1.5
1.1
—
—
—
0
0
6
93
0.64
0.42
1.2
1.8
—
—
—
0
0
5
33
1.52
0.41
5.8
2.3
433.80
811.76
u/ml
—
5
33
11
79
1.40
0.41
1.2
1.7
—
—
—
0
0
37
315
1.18
0.40
1.9
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
26.92
—
0
13
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
33
279
1.19
0.39
2.9
2.9
—
—
—
0
0
172
1617
1.08
0.38
2.5
2.6
4.20
5.45
e6/l
0.89
146
1467
14
107
1.31
0.37
1.3
1.7
—
—
—
0
0
12
158
0.76
0.37
1.2
1.4
—
—
—
0
0
12
158
0.76
0.37
1.2
1.4
—
—
—
0
0
9
70
1.29
0.36
3.1
2.3
—
—
—
0
0
97
891
1.10
0.36
1.4
1.9
—
—
—
0
0
91
834
1.10
0.36
3.2
2.7
10.03
8.28
umol/l
0.27
82
727
21
172
1.23
0.34
1.2
1.7
—
—
—
0
0
15
118
1.28
0.33
1.5
1.8
182.33
212.17
pmol/l
0.72
15
110
6
46
1.31
0.33
1.2
1.9
—
—
—
0
0
6
46
1.31
0.33
2.2
2.5
—
—
—
0
0
26
306
0.84
0.32
2.5
1.7
—
—
—
0
0
6
47
1.28
0.32
1.3
1.7
—
—
—
0
0
37
420
0.88
0.30
5.9
10.3
23.94
24.48
mmol/l
0.54
37
407
21
175
1.21
0.30
1.1
1.4
578.71
529.99
mg/l
0.39
21
161
15
120
1.25
0.30
1.3
1.2
—
—
—
0
0
36
317
1.14
0.28
4.5
3.6
71045.71
4506.05
u/ml
0.45
31
273
8
66
1.21
0.26
1.5
1.9
—
—
—
0
0
12
95
1.27
0.26
1.2
1.5
—
—
—
0
0
33
291
1.14
0.26
1.1
1.0
—
—
—
0
0
20
169
1.19
0.26
1.4
1.6
—
—
—
0
0
9
73
1.24
0.25
1.1
1.5
—
—
—
0
0
9
73
1.24
0.25
1.1
1.5
—
—
—
0
0
9
73
1.24
0.25
1.1
1.5
—
—
—
0
0
50
455
1.11
0.25
1.3
1.5
—
—
—
0
0
11
87
1.27
0.24
1.1
1.6
—
—
—
0
0
11
87
1.27
0.24
1.1
1.6
—
—
—
0
0
24
208
1.16
0.24
1.7
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
286
0.87
0.24
3.0
2.4
0.33
0.36
u/ml
0.17
18
158
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
12
97
1.24
0.23
1.2
1.5
—
—
—
0
0
12
97
1.24
0.23
1.2
1.5
—
—
—
0
0
5
39
1.28
0.23
4.2
2.1
—
—
—
0
0
13
157
0.83
0.22
3.8
3.5
21.94
26.85
mg/l
—
8
99
272
2642
1.04
0.21
3.6
3.8
315.03
117.92
e6/l
0.45
199
1924
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
16.95
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
163
1566
1.05
0.21
4.0
4.2
1.02
1.02
kg/l
0.04
28
230
22
192
1.15
0.21
1.6
2.4
88.32
90.16
%
0.15
22
185
6
48
1.25
0.20
1.2
1.5
76.83
82.19
umol/l
—
6
48
0
14
0.00
0.20
0.0
1.1
—
8.11
—
0
14
13
108
1.21
0.20
6.8
5.8
12.73
11.91
mg/l
0.28
13
100
6
51
1.18
0.19
1.5
1.2
—
—
—
0
0
19
217
0.87
0.18
1.1
1.2
—
—
—
0
0
118
1233
0.95
0.18
2.8
3.0
2.60
2.14
e6/l
0.24
64
694
15
128
1.17
0.18
1.1
1.6
—
—
—
0
0
15
128
1.17
0.18
1.1
1.6
—
—
—
0
0
23
204
1.13
0.18
1.6
1.6
—
—
—
0
0
19
216
0.88
0.17
3.1
1.8
4.37
5.43
mg/l
0.15
14
177
7
61
1.15
0.17
1.0
1.0
—
—
—
0
0
237
2308
1.04
0.17
3.2
3.3
76.28
104.16
e6/l
0.29
185
1804
7
63
1.11
0.17
1.3
1.2
13.00
11.16
u/l
—
7
56
127
1320
0.96
0.16
2.4
2.8
5.43
1.07
e6/l
0.60
75
775
17
149
1.14
0.15
1.2
1.2
—
—
—
0
0
9
80
1.13
0.15
1.3
1.8
—
—
—
0
0
8
98
0.81
0.13
5.5
4.8
307.75
359.97
umol/l
—
8
88
68
713
0.95
0.13
4.2
7.2
1.40
1.40
mmol/l
0.01
68
695
62
591
1.05
0.12
2.9
2.9
59.23
62.75
ml/min/173m2
0.34
31
248
32
343
0.93
0.11
2.3
1.8
—
—
—
0
0
83
861
0.96
0.11
4.2
4.2
13.37
20.17
ug/l
0.35
71
716
11
96
1.15
0.10
1.3
1.5
—
—
—
0
0
11
96
1.15
0.10
1.3
1.5
—
—
—
0
0
20
218
0.92
0.10
1.1
1.2
—
—
—
0
0
14
156
0.90
0.10
1.1
1.4
9.33
68.69
e6/l
—
9
122
97
940
1.04
0.10
4.8
7.8
0.49
1.25
mmol/l
1.46
76
743
11
97
1.14
0.09
1.3
1.5
—
—
—
0
0
7
64
1.09
0.08
1.1
1.4
—
—
—
0
0
96
935
1.03
0.08
4.8
7.8
13.38
11.97
kpa
1.28
91
897
29
306
0.95
0.07
1.6
1.3
—
—
—
0
0
7
85
0.82
0.07
1.1
1.1
—
—
—
0
0
14
128
1.10
0.06
1.3
1.8
—
—
—
0
0
48
494
0.97
0.04
1.5
1.6
—
—
—
0
0
50
512
0.98
0.03
5.0
9.6
93.15
93.86
%
0.17
50
506
78
793
0.98
0.03
1.4
1.4
—
—
—
0
0
215
2135
1.01
0.03
2.9
3.3
1.89
0.48
e6/l
0.74
166
1641
16
168
0.95
0.02
1.3
1.3
—
—
—
0
0
16
168
0.95
0.02
1.5
1.5
—
—
—
0
0
20
192
1.04
0.02
1.6
1.5
—
—
—
0
0
71
720
0.98
0.02
1.6
1.7
1.58
1.56
%
0.05
60
603
16
167
0.96
0.01
1.3
1.4
—
—
—
0
0
188
1889
0.99
0.01
3.6
4.1
85.17
87.97
%
0.73
183
1847
20
194
1.03
0.00
3.1
2.3
138.67
88.92
ug/min
—
9
112
39
396
0.98
0.00
1.3
1.2
175.90
162.23
iu/ml
0.06
13
159
23
226
1.02
0.00
1.2
1.3
—
—
—
0
0
31
306
1.01
0.00
4.9
2.7
—
—
—
0
0
44
444
0.99
0.00
2.0
1.8
—
—
—
0
0
16
162
0.99
0.00
1.2
1.3
—
—
—
0
0
67
669
1.00
0.00
2.9
2.4
39.42
40.01
u/l
0.02
62
557
12
117
1.03
0.00
1.2
1.1
—
—
—
0
0
19
187
1.02
0.00
1.6
1.3
—
—
—
0
0
21
205
1.03
0.00
1.4
1.7
20222.23
16279.11
e6/l
0.19
13
153
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.3
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
0.38
—
0
8
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
9
91
0.99
-0.00
1.1
1.1
1.66
1.52
g/l
—
9
79
9
89
1.01
-0.00
3.6
3.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
8
84
0.95
-0.00
1.9
2.4
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
84
0.95
-0.00
1.1
1.2
133.00
117.03
%
—
8
76
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
63
0.95
-0.00
2.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINOCHISISCYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINOCHISISCYST | 0.746 [0.64, 0.86] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 2255 females with H7_RETINOCHISISCYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINOCHISISCYST | 0.806 [0.7, 0.93] | 0.003 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 391 out of 2318 males with H7_RETINOCHISISCYST died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINOCHISISCYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.188% |
| 5 | 0.386% | 0.962% |
| 10 | 0.962% | 2.488% |
| 15 | 1.992% | 4.683% |
| 20 | 3.487% | 8.127% |
Relationships between endpoints
↥Index endpoint: H7_RETINOCHISISCYST – Retinoschisis and retinal cysts
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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