Severe visual impairment, monocular

H7_SEVVISIMPMONOC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H54.5 Cause of death: ICD-10 — H54.5 2 out of 7 registries used, show all original rules.	306
4. Check minimum number of events None	306
5. Include endpoints None	306
6. Filter based on genotype QC (FinnGen only)	306

Control definitions (FinnGen only)

Control exclude: H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H54
Name in latin: Amblyopia unius oculi

NAME	H7_SEVVISIMPMONOC
CONTROL_EXCLUDE	H7_VISUALDISTBLIND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H545
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H545
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Severe visual impairment, monocular based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2596	1398	1186
Only index persons	2197	1205	992
Unadjusted period prevalence (%)
Whole population	0.04	0.04	0.03
Only index persons	0.04	0.04	0.04
Median age at first event (years)
Whole population	50.93	57.12	43.50
Only index persons	56.01	61.87	48.88

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	306	187	119
Unadjusted period prevalence (%)	0.06	0.06	0.05
Median age at first event (years)	64.62	62.43	68.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
261: Matched controls
2608

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H54.5

ICD-10 Finland

Severe visual impairment, monocular

+∞

323.0

261

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

11.9

31.9

H54.2

ICD-10 Finland

Moderate visual impairment, binocular

313.3

28.3

Z96.1

ICD-10 Finland

Presence of intraocular lens

5.6

25.8

210

H53.0

ICD-10 Finland

Amblyopia ex anopsia

227.4

20.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.6

20.8

234

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

6.4

20.1

106

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.6

19.8

141

XCK00

NOMESCO Finland

Perimetry

6.5

17.7

S01ED51

ATC

timolol, combinations; ophthalmic

5.8

17.6

110

H53.1

ICD-10 Finland

Subjective visual disturbances

21.1

17.2

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

3.1

15.9

123

586

H53.4

ICD-10 Finland

Visual field defects

+∞

14.7

CKW99

NOMESCO Finland

Other operation on choroid, vitreous body and retina

38.5

14.6

CS494

NOMESCO Finland

Other visual field testing

17.0

14.2

XCK10

NOMESCO Finland

Photography of fundus of eye

4.5

13.9

136

WX140

NOMESCO Finland

Parabulbar anesthesy

7.3

13.0

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

6.9

12.8

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

6.3

12.6

H35.30

ICD-10 Finland

Kuhnt-Junius degeneration

5.9

12.4

114

Kela drug reimbursment

Glaucoma

4.0

11.8

141

H26.4

ICD-10 Finland

After-cataract

4.1

11.8

136

H25.1

ICD-10 Finland

Senile nuclear cataract

2.7

11.5

473

S01EE01

ATC

latanoprost; ophthalmic

4.8

11.2

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

8.3

10.6

AA1AD

NOMESCO Finland

CT of head and brain

2.7

10.4

389

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

19.8

10.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.4

10.3

128

748

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

2.4

10.0

114

633

H43.1

ICD-10 Finland

Vitreous haemorrhage

8.4

9.8

37300

ICD-8 Finland

Strabismus, Concomitans convergens

57.2

9.7

H54.4

ICD-10 Finland

Blindness, monocular

103.6

9.5

H47.2

ICD-10 Finland

Optic atrophy

+∞

9.4

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

5.1

9.4

H34.8

ICD-10 Finland

Other retinal vascular occlusions

7.6

8.9

H53.9

ICD-10 Finland

Visual disturbance, unspecified

13.4

8.5

XCD10

NOMESCO Finland

Electrophysiological examination of eye

7.2

8.2

H53.2

ICD-10 Finland

Diplopia

34.5

8.1

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

22.9

8.1

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.1

8.0

128

811

H26.02

ICD-10 Finland

Presenil cataract

8.9

7.9

TAB00

NOMESCO Finland

Lumbar puncture

7.4

7.9

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.8

7.7

CJB10

NOMESCO Finland

Laser discission of secondary cataract

3.3

7.5

123

S01EC54

ATC

brinzolamide, combinations; ophthalmic

13.9

7.5

CS424

NOMESCO Finland

Visual field testing with Goldmann perimetry

82.3

7.5

H33.0

ICD-10 Finland

Retinal detachment with retinal break

7.2

7.4

S01EC01

ATC

acetazolamide; systemic

6.6

7.4

R51.80

ICD-10 Finland

Headache

2.8

7.2

202

H34.1

ICD-10 Finland

Central retinal artery occlusion

20.7

7.2

Z2446

NOMESCO Finland

Social worker

3.9

7.2

Z49.1

ICD-10 Finland

Extracorporeal dialysis

12.5

7.2

T89

ICPC

Diabetes insulin dependent

5.8

7.1

S01ED01

ATC

timolol; ophthalmic

4.3

7.0

H57.1

ICD-10 Finland

Ocular pain

6.0

6.9

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

7.5

6.8

S01EE03

ATC

bimatoprost; ophthalmic

6.7

CHF05

NOMESCO Finland

Transscleral laser coagulation of ciliary body

23.2

6.7

CKC12

NOMESCO Finland

Photocoagulation of retina

4.8

6.4

CKC10

NOMESCO Finland

Local photocoagulation of retina

8.5

6.4

H50.1

ICD-10 Finland

Divergent concomitant strabismus

18.6

6.3

CKD93

NOMESCO Finland

Extended combined procedure on vitreous body and retina

27.4

6.3

XCH00

NOMESCO Finland

Eye pressure measurement

4.9

6.2

V03AE01

ATC

polystyrene sulfonate; oral

12.9

6.1

H3603, E103

ICD-10 Finland

12.9

6.1

A10AE04

ATC

insulin glargine; parenteral

3.1

6.0

113

Mortality – FinRegistry

↥

Association

Association between endpoint H7_SEVVISIMPMONOC and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_SEVVISIMPMONOC	1.039 [0.83, 1.3]	0.732
Birth year	0.998 [0.99, 1.01]	0.58

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1136 females with H7_SEVVISIMPMONOC died.

Males

Parameter	HR [95% CI]	p-value
H7_SEVVISIMPMONOC	1.545 [1.1, 2.16]	0.011
Birth year	0.987 [0.98, 1.0]	0.005

During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 954 males with H7_SEVVISIMPMONOC died.

Mortality risk

Mortality risk for people of age

years, who have H7_SEVVISIMPMONOC.

N-year risk	Females	Males
1	0.117%	0.283%
5	0.654%	1.82%
10	1.606%	4.232%
15	3.138%	8.11%
20	5.713%	14.077%

Relationships between endpoints

↥

Index endpoint: H7_SEVVISIMPMONOC – Severe visual impairment, monocular

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Severe visual impairment, monocular

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints