No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
306 |
4. Check minimum number of eventsNone |
306 |
5. Include endpointsNone |
306 |
6. Filter based on genotype QC (FinnGen only) |
306 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amblyopia unius oculi
Similar endpoints
↥List of similar endpoints to
Severe visual impairment, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2596 | 1398 | 1186 |
| Only index persons | 2197 | 1205 | 992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 50.93 | 57.12 | 43.50 |
| Only index persons | 56.01 | 61.87 | 48.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 306 | 187 | 119 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | 64.62 | 62.43 | 68.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 261
- Matched controls
- 2608
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.5
ICD-10 Finland
Severe visual impairment, monocular
+∞
323.0
261
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.9
31.9
61
65
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
313.3
28.3
28
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.6
25.8
86
210
H53.0
ICD-10 Finland
Amblyopia ex anopsia
227.4
20.9
21
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
20.8
82
234
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.4
20.1
56
106
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.6
19.8
63
141
XCK00
NOMESCO Finland
Perimetry
6.5
17.7
48
87
S01ED51
ATC
timolol, combinations; ophthalmic
5.8
17.6
53
110
H53.1
ICD-10 Finland
Subjective visual disturbances
21.1
17.2
25
13
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.1
15.9
123
586
H53.4
ICD-10 Finland
Visual field defects
+∞
14.7
14
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
38.5
14.6
18
5
CS494
NOMESCO Finland
Other visual field testing
17.0
14.2
22
14
XCK10
NOMESCO Finland
Photography of fundus of eye
4.5
13.9
52
136
WX140
NOMESCO Finland
Parabulbar anesthesy
7.3
13.0
31
47
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
6.9
12.8
32
52
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
6.3
12.6
34
61
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
5.9
12.4
35
67
114
Kela drug reimbursment
Glaucoma
4.0
11.8
49
141
H26.4
ICD-10 Finland
After-cataract
4.1
11.8
48
136
H25.1
ICD-10 Finland
Senile nuclear cataract
2.7
11.5
98
473
S01EE01
ATC
latanoprost; ophthalmic
4.8
11.2
38
90
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
8.3
10.6
23
30
AA1AD
NOMESCO Finland
CT of head and brain
2.7
10.4
84
389
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
19.8
10.4
15
8
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
10.3
128
748
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.4
10.0
114
633
H43.1
ICD-10 Finland
Vitreous haemorrhage
8.4
9.8
21
27
37300
ICD-8 Finland
Strabismus, Concomitans convergens
57.2
9.7
11
*
H54.4
ICD-10 Finland
Blindness, monocular
103.6
9.5
10
*
H47.2
ICD-10 Finland
Optic atrophy
+∞
9.4
9
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.1
9.4
29
62
H34.8
ICD-10 Finland
Other retinal vascular occlusions
7.6
8.9
20
28
H53.9
ICD-10 Finland
Visual disturbance, unspecified
13.4
8.5
14
11
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.2
8.2
19
28
H53.2
ICD-10 Finland
Diplopia
34.5
8.1
10
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
22.9
8.1
11
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
8.0
128
811
H26.02
ICD-10 Finland
Presenil cataract
8.9
7.9
16
19
TAB00
NOMESCO Finland
Lumbar puncture
7.4
7.9
18
26
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.8
7.7
32
92
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
7.5
37
123
S01EC54
ATC
brinzolamide, combinations; ophthalmic
13.9
7.5
12
9
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
82.3
7.5
8
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.2
7.4
17
25
S01EC01
ATC
acetazolamide; systemic
6.6
7.4
18
29
R51.80
ICD-10 Finland
Headache
2.8
7.2
49
202
H34.1
ICD-10 Finland
Central retinal artery occlusion
20.7
7.2
10
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
12.5
7.2
12
10
T89
ICPC
Diabetes insulin dependent
5.8
7.1
19
35
S01ED01
ATC
timolol; ophthalmic
4.3
7.0
25
63
H57.1
ICD-10 Finland
Ocular pain
6.0
6.9
18
32
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.5
6.8
15
21
S01EE03
ATC
bimatoprost; ophthalmic
6.7
6.7
16
25
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
23.2
6.7
9
*
CKC12
NOMESCO Finland
Photocoagulation of retina
4.8
6.4
20
44
CKC10
NOMESCO Finland
Local photocoagulation of retina
8.5
6.4
13
16
H50.1
ICD-10 Finland
Divergent concomitant strabismus
18.6
6.3
9
5
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
27.4
6.3
8
*
XCH00
NOMESCO Finland
Eye pressure measurement
4.9
6.2
19
41
H3603, E103
ICD-10 Finland
NA
12.9
6.1
10
8
V03AE01
ATC
polystyrene sulfonate; oral
12.9
6.1
10
8
A10AE04
ATC
insulin glargine; parenteral
3.1
6.0
32
113
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
284
3.12
14.78
10.6
7.5
—
—
—
0
0
176
1107
2.39
12.43
9.6
5.5
1.2
1.2
mmol/l
0.06
147
997
106
575
2.29
10.11
2.9
2.3
—
—
—
0
0
125
736
2.18
9.67
2.2
2.1
103.6
216.5
u/l
5.97
116
685
179
1218
2.13
9.43
12.2
6.4
1.2
1.2
mmol/l
0.23
151
1024
64
289
2.54
9.10
6.0
4.3
36.4
32.8
%
1.18
42
185
30
88
3.67
9.03
1.8
1.9
—
—
—
0
0
38
139
2.98
8.05
1.7
2.0
—
—
—
0
0
91
508
2.13
7.80
1.8
1.7
1076.8
1212.5
nmol/l
0.73
61
388
150
1011
1.95
7.53
2.1
2.0
101.7
94.6
pmol/l
0.92
78
519
241
1917
2.21
7.52
9.4
7.1
81.7
79.0
u/l
0.36
218
1782
181
1308
1.94
7.29
5.2
5.9
11.2
11.8
umol/l
0.21
163
1234
29
96
3.23
7.26
2.0
2.0
—
—
—
0
0
195
1455
1.94
7.02
5.9
4.5
6.9
6.7
mmol/l
0.29
186
1334
267
2259
2.43
6.49
6.1
4.7
2.1
1.9
mu/l
0.95
227
2052
125
831
1.85
6.24
3.7
3.2
2.4
2.4
mmol/l
0.05
95
726
13
27
4.98
6.03
1.1
1.1
—
—
—
0
0
42
189
2.42
5.93
16.0
6.3
12.2
9.6
mmol/l
1.25
37
178
199
1541
1.83
5.88
3.6
2.8
40.2
45.2
u/l
0.70
173
1446
149
1069
1.77
5.61
6.8
4.2
35.5
35.2
g/l
0.22
127
1003
97
613
1.85
5.58
1.6
1.6
19.9
20.9
nmol/l
0.21
75
525
73
421
1.96
5.53
1.8
2.0
—
—
—
0
0
138
972
1.76
5.51
5.4
4.0
69.6
41.6
ng/l
0.28
107
696
285
2545
2.75
5.09
25.9
16.7
4.0
4.0
mmol/l
1.42
275
2465
262
2263
2.10
5.02
4.7
3.9
1.3
1.3
mmol/l
0.19
222
2064
140
1010
1.71
5.00
2.7
2.2
70.8
77.2
nmol/l
1.98
116
902
97
631
1.79
5.00
2.6
2.1
3.6
3.2
mg/l
0.53
77
548
275
2424
2.33
4.93
5.6
4.9
2.6
2.7
mmol/l
0.55
243
2220
284
2540
2.64
4.90
25.9
16.6
139.4
139.7
mmol/l
0.94
274
2460
270
2365
2.20
4.88
5.2
4.3
4.5
4.6
mmol/l
0.28
239
2180
34
152
2.39
4.87
8.3
4.1
1.7
2.1
mmol/l
0.16
28
114
43
213
2.19
4.86
3.0
2.6
4.6
8.3
ug/l
1.04
32
189
14
38
3.81
4.70
8.2
8.6
127.4
484.3
iu/ml
—
5
10
288
2602
2.82
4.69
14.1
10.1
24.5
25.1
u/l
0.30
266
2497
268
2351
2.13
4.66
5.4
4.3
1.5
1.5
mmol/l
0.29
234
2155
41
203
2.18
4.64
2.0
2.7
67.3
66.1
g/l
0.42
34
185
40
199
2.16
4.48
8.1
2.8
123.3
70.7
ng/l
1.92
34
178
21
77
2.85
4.45
1.1
1.7
—
144.0
—
0
5
9
12
7.69
4.38
1.1
1.3
—
—
—
0
0
223
1860
1.73
4.37
5.0
3.9
15.0
14.9
pmol/l
0.15
188
1670
10
22
4.67
4.33
5.4
2.5
—
—
—
0
0
276
2465
2.22
4.31
21.9
14.6
23.5
22.9
mg/l
0.10
232
1943
12
31
3.99
4.30
4.3
3.7
—
885.4
—
0
5
221
1844
1.71
4.26
5.6
4.0
13.3
12.8
mm/h
0.18
191
1689
268
2373
2.04
4.19
6.4
4.5
6.1
6.0
mmol/l
0.63
227
2171
150
1141
1.62
4.13
4.1
4.2
—
—
—
0
0
109
769
1.65
4.05
5.1
2.3
104.1
55.1
u/l
0.56
98
708
11
28
4.04
4.01
1.5
1.1
—
—
—
0
0
181
1451
1.61
3.94
9.6
9.1
4.3
4.1
e9/l
0.32
155
1282
8
11
7.43
3.88
1.1
1.1
—
—
—
0
0
256
2251
1.84
3.83
7.9
5.7
41.5
39.9
mmol/mol
1.34
225
2097
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
12
6.81
3.69
1.1
1.1
—
—
—
0
0
108
776
1.61
3.66
3.7
3.3
2058.5
1555.5
ng/l
0.56
90
656
10
26
3.94
3.55
1.3
1.4
—
—
—
0
0
9
17
5.42
3.53
1.4
1.0
—
—
—
0
0
6
6
10.16
3.51
1.2
1.0
—
—
—
0
0
6
6
10.16
3.51
1.2
1.0
—
—
—
0
0
6
6
10.16
3.51
1.2
1.2
—
—
—
0
0
6
6
10.16
3.51
1.2
1.3
—
—
—
0
0
6
6
10.16
3.51
1.2
1.5
—
—
—
0
0
34
175
2.06
3.50
1.4
1.5
—
—
—
0
0
12
37
3.33
3.38
1.3
1.3
—
—
—
0
0
8
14
5.83
3.36
1.1
1.1
—
—
—
0
0
80
545
1.63
3.33
7.5
4.6
1.0
1.0
kg/l
0.70
14
84
293
2734
2.69
3.25
32.6
21.4
132.8
133.9
g/l
0.67
286
2684
10
28
3.66
3.22
1.5
1.1
—
—
—
0
0
256
2285
1.74
3.20
16.8
13.7
77.0
79.1
ml/min/173m2
0.67
212
1857
42
243
1.84
3.10
1.5
1.6
1.5
1.5
%
0.10
35
216
48
290
1.78
3.09
3.6
4.3
278.3
249.3
u/l
0.22
41
274
88
629
1.56
2.97
4.4
2.7
6656.4
7028.0
umol/l
0.02
72
536
17
70
2.51
2.93
1.8
1.5
1.6
0.2
iu/ml
—
6
18
120
924
1.49
2.84
5.8
3.1
—
—
—
0
0
5
6
8.44
2.76
1.2
1.2
—
—
—
0
0
6
10
6.09
2.71
1.0
1.5
—
—
—
0
0
8
19
4.29
2.69
1.6
1.1
333.8
226.6
mg/l
—
8
19
29
156
1.95
2.67
1.8
1.4
—
—
—
0
0
57
376
1.63
2.67
2.6
3.5
0.8
0.8
mmol/l
0.25
51
354
8
20
4.08
2.58
1.1
1.1
—
—
—
0
0
37
222
1.76
2.45
1.6
1.7
353.3
378.0
nmol/l
0.35
29
204
6
12
5.08
2.41
2.5
2.8
588.8
861.7
u/ml
—
6
12
132
1062
1.43
2.40
3.7
2.6
141.0
119.5
ug/l
0.51
113
969
5
8
6.33
2.38
3.2
1.9
—
—
—
0
0
5
8
6.33
2.38
2.0
1.3
—
—
—
0
0
11
41
2.75
2.30
1.0
1.4
—
—
—
0
0
6
13
4.68
2.28
1.7
1.2
3.6
1.8
mmol/l
—
6
13
38
235
1.70
2.27
5.8
3.9
1.7
2.1
mmol/l
0.25
29
182
26
143
1.89
2.27
1.1
1.3
227.6
140.0
iu/ml
—
9
63
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
74
2.23
2.19
2.5
2.1
0.3
0.4
u/ml
—
10
41
9
30
3.06
2.16
1.2
1.8
—
—
—
0
0
21
110
1.98
2.11
2.0
2.5
1.5
1.5
g/l
0.02
16
97
241
2186
1.48
2.10
20.5
15.4
38.3
39.5
%
0.88
155
1559
5
10
5.06
2.08
1.0
1.0
1156.6
1575.4
miu/ml
—
5
10
150
1258
1.38
2.05
5.7
4.2
0.0
0.0
estimate
0.00
16
257
33
204
1.69
1.99
5.6
3.4
4.7
4.3
kpa
0.35
33
193
76
570
1.44
1.97
1.5
1.8
437.8
445.3
pmol/l
0.07
61
475
148
1244
1.37
1.97
6.4
5.6
0.0
0.0
estimate
0.00
15
258
15
71
2.17
1.95
2.9
3.5
1.7
1.5
mg/l
0.34
15
65
5
11
4.60
1.95
1.0
1.5
—
18.0
—
0
6
5
11
4.60
1.95
1.0
1.0
—
—
—
0
0
6
16
3.80
1.94
1.2
1.7
—
—
—
0
0
10
39
2.62
1.94
1.8
1.4
—
—
—
0
0
65
476
1.46
1.91
2.8
2.9
2.4
2.5
mmol/l
0.70
57
414
146
1234
1.35
1.84
5.6
4.1
0.0
0.0
estimate
0.00
15
263
43
295
1.53
1.72
1.5
2.0
—
—
—
0
0
69
521
1.42
1.72
1.7
1.7
1.1
1.3
mg/l
0.54
51
401
5
13
3.89
1.72
1.2
1.2
—
—
—
0
0
42
287
1.54
1.72
2.4
2.5
15.7
9.2
umol/l
0.37
36
242
6
19
3.20
1.67
1.0
1.2
—
—
—
0
0
5
14
3.61
1.62
1.2
1.1
—
—
—
0
0
42
293
1.50
1.57
1.5
1.9
—
—
—
0
0
47
337
1.47
1.54
4.4
2.2
21.8
21.8
%
0.01
42
291
7
27
2.63
1.52
2.0
1.1
—
—
—
0
0
86
689
1.35
1.49
6.4
4.5
0.0
0.0
estimate
0.00
15
254
34
229
1.55
1.49
2.2
2.2
0.2
0.2
g/l
0.26
26
216
29
188
1.60
1.49
2.1
2.6
56.5
64.0
ml/min/173m2
1.03
15
84
9
37
2.47
1.49
1.3
1.3
153.0
249.5
u/ml
—
9
21
59
445
1.40
1.48
3.1
2.5
1.0
1.0
e6/l
0.02
41
259
7
28
2.53
1.46
1.3
1.9
—
—
—
0
0
40
282
1.48
1.43
4.8
6.2
1.0
1.4
mmol/l
0.24
28
226
6
23
2.64
1.37
2.0
3.6
19.8
84.5
u/ml
—
6
23
14
77
1.86
1.27
1.1
3.8
—
3.0
—
0
9
34
243
1.45
1.16
5.2
2.1
28.3
32.5
u/l
0.60
28
205
68
547
1.31
1.14
1.4
1.3
0.7
1.7
u/ml
1.61
20
144
113
972
1.26
1.12
5.8
4.4
—
—
—
0
0
5
21
2.40
1.09
3.2
2.1
0.3
0.2
e9/l
—
5
16
11
59
1.90
1.08
2.5
3.2
0.8
1.0
nmol/l
0.29
11
48
20
129
1.59
1.08
1.2
1.0
—
—
—
0
0
13
74
1.79
1.08
1.2
1.9
—
—
—
0
0
10
52
1.95
1.07
1.0
1.1
—
17.6
—
0
5
5
22
2.29
1.04
3.2
2.1
391.2
522.0
e6/l
—
5
16
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
164
1487
1.22
0.97
3.1
3.0
—
—
—
0
0
9
51
1.79
0.95
1.1
1.4
—
—
—
0
0
10
56
1.81
0.89
1.1
1.1
—
—
—
0
0
86
736
1.23
0.88
3.8
3.0
0.2
0.4
e6/l
1.32
68
555
11
64
1.75
0.87
1.5
1.2
—
—
—
0
0
12
73
1.67
0.83
1.8
1.2
—
—
—
0
0
7
122
0.56
0.79
1.4
1.5
—
—
—
0
0
12
75
1.62
0.76
1.8
1.2
—
—
—
0
0
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
5
25
2.02
0.73
2.6
3.0
—
—
—
0
0
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
9
57
1.60
0.71
1.4
1.9
—
—
—
0
0
15
101
1.51
0.71
1.8
1.8
4.8
3.9
ug/l
—
10
89
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.4
1.2
—
—
—
0
0
12
177
0.66
0.65
1.3
1.7
—
—
—
0
0
8
49
1.65
0.62
1.6
1.5
—
—
—
0
0
5
30
1.68
0.61
1.4
1.6
—
—
—
0
0
5
30
1.68
0.61
1.4
1.6
—
—
—
0
0
20
148
1.38
0.61
6.7
7.8
24.2
24.9
mmol/l
0.52
20
148
12
80
1.52
0.60
1.2
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.5
—
13.2
—
0
20
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
11
73
1.53
0.57
1.7
2.8
—
—
—
0
0
6
39
1.55
0.53
1.5
1.1
—
—
—
0
0
12
84
1.45
0.50
1.5
1.4
—
—
—
0
0
7
109
0.63
0.49
4.4
2.8
62.0
384.4
u/ml
—
7
95
78
700
1.15
0.47
5.7
4.9
3.3
2.9
ug/l
0.11
68
618
32
265
1.23
0.47
3.6
3.6
—
—
—
0
0
7
51
1.38
0.44
1.7
1.5
—
—
—
0
0
5
31
1.62
0.43
1.4
1.6
—
—
—
0
0
5
31
1.62
0.43
1.4
1.6
—
—
—
0
0
5
31
1.62
0.43
1.4
1.6
—
—
—
0
0
5
31
1.62
0.43
1.4
1.6
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
47
410
1.17
0.41
3.2
2.8
1.6
2.2
e6/l
0.52
28
226
5
33
1.52
0.41
1.2
1.4
0.6
0.5
nmol/l
—
5
28
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
4.2
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
9
71
1.28
0.36
1.2
1.6
—
—
—
0
0
202
2092
0.90
0.36
21.1
17.6
13.8
13.8
%
0.29
197
2061
6
46
1.31
0.33
1.0
1.6
—
—
—
0
0
17
137
1.26
0.33
1.6
2.8
0.2
0.1
e6/l
0.19
17
130
7
52
1.35
0.31
1.3
1.6
—
—
—
0
0
7
54
1.30
0.30
1.4
1.6
42.0
39.3
nmol/l
—
7
54
7
57
1.23
0.29
1.3
1.5
—
—
—
0
0
8
64
1.26
0.27
1.4
1.4
—
—
—
0
0
10
77
1.31
0.26
1.3
2.1
—
—
—
0
0
15
123
1.23
0.26
1.7
1.3
—
—
—
0
0
9
76
1.19
0.25
2.0
1.9
—
—
—
0
0
24
275
0.86
0.24
2.1
2.2
—
—
—
0
0
51
470
1.10
0.22
5.4
4.1
43.6
171.8
ng/l
2.12
40
380
35
387
0.89
0.22
1.3
1.3
1.6
8.8
u/ml
—
8
153
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
309.7
—
0
6
60
559
1.09
0.21
5.5
4.4
22.9
21.5
%
0.26
28
280
0
13
0.00
0.21
0.0
2.2
—
78.3
—
0
13
0
13
0.00
0.21
0.0
1.7
—
7.8
—
0
7
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
44
405
1.10
0.20
3.2
3.0
1.3
0.9
ug/l
0.35
24
272
6
53
1.13
0.19
1.3
1.4
—
—
—
0
0
6
53
1.13
0.19
1.3
1.4
—
—
—
0
0
7
59
1.19
0.18
1.3
1.4
—
—
—
0
0
44
408
1.09
0.17
1.3
1.3
12.6
40.7
iu/ml
—
10
138
8
70
1.15
0.16
1.3
1.6
—
—
—
0
0
68
649
1.06
0.13
1.6
1.6
1.5
1.3
mmol/l
0.60
58
544
40
425
0.93
0.12
1.6
1.4
—
—
—
0
0
13
114
1.15
0.12
1.8
1.8
—
—
—
0
0
11
97
1.14
0.09
1.3
2.1
—
—
—
0
0
23
241
0.95
0.04
1.9
2.0
—
—
—
0
0
15
141
1.07
0.03
1.9
2.0
—
—
—
0
0
14
132
1.06
0.02
4.7
2.9
36.4
58.7
u/ml
0.36
14
125
38
373
1.02
0.01
1.7
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
62
0.97
0.00
1.2
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
8.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
8.1
—
0
9
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
8.1
—
0
8
0
7
0.00
0.00
0.0
1.0
—
7.3
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H7_SEVVISIMPMONOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPMONOC | 1.039 [0.83, 1.3] | 0.732 |
| Birth year | 0.998 [0.99, 1.01] | 0.58 |
During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1136 females with H7_SEVVISIMPMONOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPMONOC | 1.545 [1.1, 2.16] | 0.011 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 954 males with H7_SEVVISIMPMONOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_SEVVISIMPMONOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.283% |
| 5 | 0.654% | 1.82% |
| 10 | 1.606% | 4.232% |
| 15 | 3.138% | 8.11% |
| 20 | 5.713% | 14.077% |
Relationships between endpoints
↥Index endpoint: H7_SEVVISIMPMONOC – Severe visual impairment, monocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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