No definition available.
Heart failure and hypertrophic cardiomyopathy
I9_HEARTFAIL_AND_HYPERTCARDIOM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
1436 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
583 |
6. Filter based on genotype QC (FinnGen only) |
583 |
Control definitions (FinnGen only)
- Control conditions
- not I9_HYPERTROCARDMYOP
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Heart failure and hypertrophic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
- Hypertrophic cardiomyopathy
- Cardiomyopathy
- Heart failure, strict
- Heart failure,strict
- Heart failure, not strict
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3880 | 1606 | 2239 |
| Only index persons | 3162 | 1299 | 1863 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 64.57 | 67.92 | 62.15 |
| Only index persons | 64.98 | 68.74 | 62.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 583 | 215 | 368 |
| Unadjusted period prevalence (%) | 0.13 | 0.07 | 0.16 |
| Median age at first event (years) | 61.93 | 63.99 | 60.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 537
- Matched controls
- 5370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
10544.9
323.0
386
*
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
307.9
265
*
I50.9
ICD-10 Finland
Heart failure, unspecified
29.0
244.8
422
602
I42.0
ICD-10 Finland
Dilated cardiomyopathy
60.1
202.5
236
69
C03CA01
ATC
furosemide; systemic
23.3
191.4
475
1329
C03DA01
ATC
spironolactone; oral
15.5
157.4
306
423
201
Kela drug reimbursment
Chronic cardiac insufficiency
24.7
154.1
230
158
I50.0
ICD-10 Finland
Congestive heart failure
16.4
140.3
252
275
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
52.5
134.1
160
43
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.5
129.4
329
700
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
15.0
122.8
226
248
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
9.1
118.8
357
960
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
17.2
117.7
200
179
B01AA03
ATC
warfarin; systemic
9.0
117.4
350
923
I50.1
ICD-10 Finland
Left ventricular failure
17.0
115.1
196
175
I48
ICD-10 Finland
Atrial fibrillation and flutter
8.4
112.0
364
1070
C07AB07
ATC
bisoprolol; oral
10.7
105.8
472
2164
C01BD01
ATC
amiodarone; systemic
25.6
97.2
139
72
207
Kela drug reimbursment
Chronic arrhythmias
7.7
91.4
266
607
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
32.8
77.1
102
38
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
13.1
76.0
142
143
I47.2
ICD-10 Finland
Ventricular tachycardia
25.1
74.2
106
52
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
89.3
70.2
77
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.9
65.4
225
583
AN1
HP
Coronary angiography
6.3
63.7
201
465
TFP20
NOMESCO Finland
Cardiodefibrillation
8.0
62.6
158
266
C09AA05
ATC
ramipril; oral
4.6
58.0
291
1101
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
57.2
382
1895
XF404
NOMESCO Finland
Ambulatory ECG
6.7
55.6
161
324
C01AA05
ATC
digoxin; systemic
6.4
53.3
158
326
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.5
51.5
243
839
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
7.6
47.5
120
195
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
35.2
44.3
57
18
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
30.8
43.6
58
21
GD1LA
NOMESCO Finland
GD
18.8
41.9
65
39
R06.0
ICD-10 Finland
Dyspnoea
3.7
40.5
238
946
Z94.1
ICD-10 Finland
Heart transplant status
116.6
40.4
43
*
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
43.8
39.1
48
12
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.1
39.1
184
602
XF400
NOMESCO Finland
ECG with 12 standard connections
4.0
38.3
188
637
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
31.6
37.1
49
17
C09DX04
ATC
valsartan and sacubitril; oral
27.4
36.5
50
20
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.2
36.1
163
507
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
37.6
35.6
45
13
M04AA01
ATC
allopurinol; systemic
4.1
35.3
165
529
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
186.8
34.1
35
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
7.8
33.5
81
120
I44.2
ICD-10 Finland
Atrioventricular block, complete
8.3
33.4
77
106
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
6.7
33.2
90
157
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
16.2
32.6
53
36
R4110
NOMESCO Finland
Physiotherapy
3.3
32.5
222
953
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.7
32.2
99
203
I50
ICD-10 Finland
Heart failure
8.6
32.0
72
95
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
39.1
32.0
40
11
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
6.7
30.3
81
138
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
30.2
190
759
B01AF02
ATC
apixaban; oral
4.3
29.3
123
350
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
13.8
27.7
48
38
WX740
NOMESCO Finland
Nitrogen oxide therapy
102.0
26.9
29
*
WX892
NOMESCO Finland
Monitored bed care
4.6
26.8
100
252
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
25.9
217
1029
I42
ICD-10 Finland
Cardiomyopathy
141.8
25.8
27
*
ZX120
NOMESCO Finland
Intravenous
4.3
25.5
104
285
L04AA06
ATC
mycophenolic acid; systemic
14.1
25.1
43
33
I49.5
ICD-10 Finland
Sick sinus syndrome
6.0
25.1
72
134
C07AA07
ATC
sotalol; systemic
6.2
25.0
70
126
127
Kela drug reimbursment
Transplant complication
14.1
24.6
42
32
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.8
24.6
213
1026
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.9
24.3
109
326
TK810
NOMESCO Finland
Hemofiltration
26.9
24.2
33
13
TK800
NOMESCO Finland
Hemodialysis
9.9
24.1
49
54
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
13.8
23.8
41
32
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
23.8
111
343
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
49.1
23.5
28
6
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
29.8
23.4
31
11
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
14.5
22.6
38
28
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
6.9
22.6
58
93
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
22.3
146
581
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
65.4
22.0
25
*
A12BA01
ATC
potassium chloride; oral
4.8
22.0
77
180
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
21.9
154
640
AP4
HP
Myocardial biopsy
119.9
21.7
23
*
81
HP
Angiography of the heart and coronary arteries
3.9
21.4
97
290
1CX08
NOMESCO Finland
NA
35.4
21.3
27
8
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.7
21.2
76
182
7AX01
NOMESCO Finland
NA
+∞
21.0
20
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
20.7
87
243
WX872
NOMESCO Finland
Intensive care
4.9
20.3
69
156
TFJ02
NOMESCO Finland
Muscle biopsy of heart
50.1
20.3
24
5
G04BE03
ATC
sildenafil; oral
10.2
20.2
40
42
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.6
20.1
60
117
XF640
NOMESCO Finland
NA
6.8
19.8
51
82
C07AG02
ATC
carvedilol; oral
4.1
19.3
79
215
AS8
HP
Physiological arrhythmia pacemaker insertionDDD (R) S
+∞
18.9
18
*
TFP35
NOMESCO Finland
Electroanatomical mapping
19.6
18.8
28
15
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
18.8
70
174
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.5
18.6
69
171
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.4
18.4
98
332
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
18.3
111
413
C07AB02
ATC
metoprolol; systemic
2.5
18.3
177
878
4251A
ICD-9 Finland
Cardiomyopathy, Hypertrophic obstructive cardiomyopathy
+∞
17.8
17
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
6.7
17.6
45
72
ZX108
NOMESCO Finland
Inhalation
17.7
17.6
27
16
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.0
17.4
58
128
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
12.6
17.0
30
25
H02AB06
ATC
prednisolone; systemic
2.2
16.9
298
1953
K78
ICPC
Atrial fibrillation/flutter
3.3
16.9
93
322
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
5.9
16.6
47
86
AP2
HP
Catheterization of the right side of the heart
31.1
16.2
21
7
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
16.1
95
345
K77
ICPC
Heart failure
7.5
16.1
38
54
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
6.4
15.9
42
70
TFP34
NOMESCO Finland
Electrophysiological investigation
7.0
15.9
39
59
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.3
15.8
193
1060
3A064
NOMESCO Finland
NA
27.2
15.7
21
8
K84
ICPC
Heart disease other
6.7
15.7
40
64
M10.9
ICD-10 Finland
Gout, unspecified
3.5
15.6
76
239
FXL00
NOMESCO Finland
Insertion and use of extra-, para- or intracorporeal VAD
164.6
15.6
16
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
39.3
15.5
19
5
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.6
15.2
124
549
XF402
NOMESCO Finland
ECG with work load test
2.9
15.2
104
415
AS4
HP
Physiological pacemaker insertion DDD (R)
8.9
15.2
32
38
R55
ICD-10 Finland
Syncope and collapse
2.9
15.0
100
392
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
15.0
187
1032
I42.8
ICD-10 Finland
Other cardiomyopathies
13.7
14.8
25
19
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
21.8
14.8
21
10
AK1
HP
HTX (heart transplant)
+∞
14.6
14
*
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
6.2
14.5
39
67
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.8
14.3
62
177
71
HP
Electrophysiological Special Examination
23.0
14.3
20
9
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.9
14.1
35
54
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.2
13.9
54
140
I48.2
ICD-10 Finland
Chronic atrial fibrillation
5.2
13.7
43
89
73
HP
Initial pacemaker installation
12.5
13.7
24
20
B01AB05
ATC
enoxaparin; parenteral
2.1
13.7
199
1167
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
77.1
13.6
15
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
13.6
178
996
XFE00
NOMESCO Finland
Epicardial ultrasonography
5.5
13.6
40
77
C01BA03
ATC
disopyramide; systemic
16.7
13.6
21
13
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
143.5
13.5
14
*
C08DA01
ATC
verapamil; systemic
4.5
13.5
48
114
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
4.8
13.4
45
101
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
13.2
173
964
3AC01
NOMESCO Finland
NA
11.4
13.1
24
22
AA1AD
NOMESCO Finland
CT of head and brain
2.1
13.0
175
986
AP1
HP
Catheterization of the left side of the heart
7.6
12.6
29
40
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
71.6
12.6
14
*
A11CC03
ATC
alfacalcidol; systemic
6.6
12.6
32
51
AP3
HP
Catheterization of the right and left side of the heart
32.9
12.6
16
5
ATX
HP
Other pacemaker replacement or related action, such as cord removal or replacement
32.9
12.6
16
5
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
20.6
12.5
18
9
C01DA14
ATC
isosorbide mononitrate; oral
2.3
12.4
138
713
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.6
12.4
58
177
205
Kela drug reimbursment
Chronic hypertension
2.0
12.3
210
1302
742
NOMESCO Finland
NA
27.4
12.1
16
6
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
10.4
12.1
23
23
N18.8
ICD-10 Finland
Other chronic renal failure
4.6
12.0
41
94
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
12.0
71
255
I45.9
ICD-10 Finland
Conduction disorder, unspecified
12.1
11.9
21
18
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
10.9
11.9
22
21
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
11.8
195
1191
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
16.9
11.7
18
11
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
11.7
58
185
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
23.5
11.6
16
7
I48.1
ICD-10 Finland
Persistent atrial fibrillation
4.8
11.5
38
84
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
11.5
124
628
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
11.5
67
241
H03BB01
ATC
carbimazole; oral
5.0
11.4
36
76
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
15.5
11.4
18
12
R02
ICPC
Shortness of breath/dyspnoea
2.5
11.4
92
403
A46
ICD-10 Finland
Erysipelas
2.3
11.4
113
550
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
9.2
11.4
23
26
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
11.4
91
394
C10AA01
ATC
simvastatin; oral
1.9
11.3
296
2126
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.7
11.2
49
142
E05.89
ICD-10 Finland
Other thyrotoxicosis
44.3
11.0
13
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.3
10.9
55
178
XF600
NOMESCO Finland
Bloodpressure measurement
3.3
10.8
56
185
N19
ICD-10 Finland
Unspecified kidney failure
4.1
10.8
41
105
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.7
10.7
30
55
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
10.6
188
1169
I20.00
ICD-10 Finland
Unstable angina
4.2
10.5
40
102
TK830
NOMESCO Finland
Ultrafiltration
+∞
10.4
10
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
10.4
83
358
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
33.2
10.4
13
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
10.3
73
294
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
10.3
59
210
R53
ICD-10 Finland
Malaise and fatigue
2.1
10.2
129
699
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.0
10.2
151
873
WX002
NOMESCO Finland
Sedation and analgesia
2.1
10.1
132
721
J01CA04
ATC
amoxicillin; systemic
1.9
10.1
404
3294
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.9
10.0
63
238
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
17.1
9.9
15
9
C03AA03
ATC
hydrochlorothiazide; oral
2.5
9.9
80
349
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
5.5
9.8
28
53
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.1
9.7
37
95
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
8.0
9.7
21
27
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.7
9.7
41
116
AQ1
HP
Conventional electrophysiological examination
8.6
9.6
20
24
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
6.2
9.6
25
42
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
9.6
86
396
FPE40
NOMESCO Finland
Replacement of transvenous cardiac pacemaker electrode
15.4
9.6
15
10
I25.2
ICD-10 Finland
Old myocardial infarction
2.6
9.5
69
284
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
9.4
196
1274
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
101.7
9.4
10
*
TFP52
NOMESCO Finland
Ablation treatment of ventricular tachycardia due to structural heart defect
101.7
9.4
10
*
I42.5
ICD-10 Finland
Other restrictive cardiomyopathy
30.6
9.4
12
*
I41.8*D86.8
ICD-10 Finland
Sarcoid myocarditis
30.6
9.4
12
*
C01BB02
ATC
mexiletine; systemic
30.6
9.4
12
*
FPJ22
NOMESCO Finland
Revision of cardioverter-defibrillator with atrial and ventricular electrodes
30.6
9.4
12
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
9.4
90
428
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.4
9.4
80
358
R00.1
ICD-10 Finland
Bradycardia, unspecified
4.1
9.4
36
93
ZX197
NOMESCO Finland
NA
+∞
9.4
9
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.2
9.1
47
156
XFP02
NOMESCO Finland
NA
37.4
9.0
11
*
ASB
HP
Insertion of a biventricular physiological pacemaker DDD (R)
37.4
9.0
11
*
C09AA02
ATC
enalapril; systemic
2.0
9.0
141
825
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.9
8.9
36
98
I44.1
ICD-10 Finland
Atrioventricular block, second degree
5.3
8.9
26
51
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.8
8.8
36
99
WX722
NOMESCO Finland
PEEP
3.3
8.8
44
143
A10BK01
ATC
dapagliflozin; oral
3.5
8.7
40
121
5AB14
NOMESCO Finland
NA
50.8
8.7
10
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.7
8.7
59
234
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
8.7
179
1156
A10AE04
ATC
insulin glargine; parenteral
2.4
8.7
75
338
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
8.6
41
128
C09AA04
ATC
perindopril; oral
3.1
8.5
48
167
R03BB04
ATC
tiotropium bromide; inhalant
2.3
8.5
80
377
I20.9
ICD-10 Finland
Angina pectoris, unspecified
7.5
8.5
19
26
63
HP
Cardiac muscle biopsy
91.4
8.4
9
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
91.4
8.4
9
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.8
8.4
34
93
A10BA02
ATC
metformin; oral
1.8
8.4
185
1217
FXM00
NOMESCO Finland
Removal of extra-, para- or intracorporeal VAD
+∞
8.4
8
*
I42.4
ICD-10 Finland
Endocardial fibroelastosis
+∞
8.4
8
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
8.3
103
549
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
14.8
8.2
13
9
A10BH05
ATC
linagliptin; oral
2.9
8.2
48
174
E85.9
ICD-10 Finland
Amyloidosis, unspecified
33.9
8.1
10
*
C01BA01
ATC
quinidine; oral
10.2
8.1
15
15
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
22.4
8.0
11
5
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.4
8.0
18
25
M10
ICD-10 Finland
Gout
3.2
7.9
40
131
N17.8
ICD-10 Finland
Other acute renal failure
7.9
7.9
17
22
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.3
7.9
38
120
L28
ICPC
Limited function/disability (L)
2.0
7.8
107
595
E66.8
ICD-10 Finland
Other obesity
4.1
7.8
29
74
R04.0
ICD-10 Finland
Epistaxis
2.5
7.8
59
249
L04AD01
ATC
ciclosporin; systemic
6.1
7.7
20
34
J01FF01
ATC
clindamycin; systemic
1.8
7.7
147
919
A10BB12
ATC
glimepiride; oral
2.4
7.7
67
304
J01DB01
ATC
cefalexin; oral
1.8
7.6
419
3568
I20.09
ICD-10 Finland
Unstable angina
2.6
7.6
53
214
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
12.1
7.6
13
11
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
12.1
7.6
13
11
2BD01
NOMESCO Finland
NA
25.4
7.6
10
*
C08CA02
ATC
felodipine; oral
2.2
7.5
76
371
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.8
7.5
155
996
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.9
7.4
44
161
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.6
7.4
32
93
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
4.3
7.4
26
63
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.9
7.4
43
156
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
+∞
7.3
7
*
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
7.3
7
*
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
+∞
7.3
7
*
FJA00
NOMESCO Finland
Biopsy of right ventricle
+∞
7.3
7
*
FPH20
NOMESCO Finland
Removal of epicardial pacemaker or cardioverter-defibrillator
+∞
7.3
7
*
61
HP
Catheterization and pressure measurement of the left side of the heart
4.8
7.3
23
50
XF622
NOMESCO Finland
Measurement of minute volume of heart
16.0
7.3
11
7
J96.1
ICD-10 Finland
Chronic respiratory failure
4.9
7.2
22
46
I24.0
ICD-10 Finland
Coronary thrombosis not resulting in myocardial infarction
30.4
7.2
9
*
G47.3
ICD-10 Finland
Sleep apnoea
1.9
7.2
122
729
Z95.9
ICD-10 Finland
Presence of cardiac and vascular implant and graft, unspecified
20.3
7.2
10
5
FPJ00
NOMESCO Finland
Revision of pacemaker pulse generator or electrode
20.3
7.2
10
5
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
20.3
7.2
10
5
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.2
7.2
77
385
B01AE07
ATC
dabigatran etexilate; oral
3.2
7.1
36
119
N05BA01
ATC
diazepam; systemic, rectal
2.1
7.0
80
409
UJF92
NOMESCO Finland
Capsular endoscopy
5.6
7.0
19
35
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
5.6
7.0
19
35
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
7.0
33
104
K08.3
ICD-10 Finland
Retained dental root
2.6
6.9
48
193
J01MA12
ATC
levofloxacin; systemic
1.8
6.9
120
725
E66.00
ICD-10 Finland
Metabolic syndrome
2.9
6.9
40
145
R50.9
ICD-10 Finland
Fever, unspecified
2.1
6.9
85
450
ZXA05
NOMESCO Finland
Left side
1.7
6.8
151
985
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
5.8
6.8
18
32
250
Kela drug reimbursment
NA
40.6
6.8
8
*
R03AC02
ATC
salbutamol; inhalant
1.6
6.7
259
1967
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.0
6.7
38
134
FM1CD
NOMESCO Finland
Very extensive CT of heart
22.8
6.7
9
*
E87.5
ICD-10 Finland
Hyperkalaemia
4.3
6.7
23
55
A02BC02
ATC
pantoprazole; systemic
1.6
6.7
345
2820
M01AH05
ATC
etoricoxib; oral
0.6
6.7
159
2199
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.4
6.7
30
91
E66.9
ICD-10 Finland
Obesity, unspecified
4.5
6.6
22
51
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
3.6
6.6
28
81
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
8.8
6.6
13
15
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.9
6.6
103
599
WX402
NOMESCO Finland
General anaesthesia
2.0
6.6
85
459
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
6.6
332
3900
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
6.5
37
130
EBA10
NOMESCO Finland
Surgical removal of tooth
2.4
6.5
55
247
B01AB04
ATC
dalteparin; parenteral
3.0
6.5
37
131
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
6.5
171
1170
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.4
6.5
52
228
FPG04
NOMESCO Finland
Insertion of internal defibrillator, atrial and chamber electrode
70.6
6.4
7
*
42509
ICD-8 Finland
Cardiomyopathy, Unspecified
70.6
6.4
7
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
70.6
6.4
7
*
ASA
HP
Insertion of a biventricular pacemaker VVI (R) S
70.6
6.4
7
*
120
NOMESCO Finland
NA
70.6
6.4
7
*
3A149
NOMESCO Finland
NA
70.6
6.4
7
*
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
14.5
6.4
10
7
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.7
6.4
41
157
R18
ICD-10 Finland
Ascites
4.7
6.3
20
44
-
ICD-10 Finland
NA
4.4
6.3
21
49
C08DB01
ATC
diltiazem; oral
2.5
6.3
47
197
J94.8
ICD-10 Finland
Other specified pleural conditions
4.9
6.3
19
40
62
HP
Catheterization and pressure measurement of the right side of the heart
18.3
6.3
9
5
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
6.3
6
*
Z45.9
ICD-10 Finland
Adjustment and management of unspecified implanted device
+∞
6.3
6
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.2
6.3
30
96
I41.8
ICD-10 Finland
Myocarditis in other diseases classified elsewhere
27.0
6.2
8
*
AS6
HP
Biventricular physiological heart failure pacemaker insertion DDD (R)
27.0
6.2
8
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
27.0
6.2
8
*
FPE36
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with ventricular electrodes
27.0
6.2
8
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
27.0
6.2
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
6.2
86
477
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
6.2
144
949
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
6.2
47
200
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.2
6.2
58
275
N05CF01
ATC
zopiclone; oral
1.6
6.2
185
1306
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
6.1
342
2820
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.1
445
3941
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.2
6.1
21
51
D86.0
ICD-10 Finland
Sarcoidosis of lung
6.8
6.1
14
21
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
10.2
6.1
11
11
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.4
6.0
49
216
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
442
1716
7.52
111.89
12.7
3.1
4025.8
1606.6
ng/l
10.69
428
1480
274
726
6.23
105.22
4.7
2.4
21.3
22.9
%
1.15
258
619
279
759
6.13
103.84
4.7
2.4
2.3
2.3
g/l
0.82
262
700
290
826
6.00
102.23
4.7
2.5
12.5
12.6
umol/l
0.09
275
767
206
467
6.28
92.26
8.2
3.3
561.2
233.5
ng/l
6.49
201
423
206
474
6.17
90.64
27.2
6.8
13.5
10.4
mmol/l
5.12
197
450
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
118
196
7.29
70.97
5.0
2.4
0.4
0.4
u/ml
0.07
68
105
241
826
4.27
62.15
12.2
3.3
0.8
0.8
mmol/l
1.35
227
770
220
706
4.40
62.05
11.0
5.3
1.1
1.0
mmol/l
4.85
202
654
175
483
4.75
59.84
5.2
2.6
28.5
7.9
ug/l
4.04
162
425
111
219
6.03
55.69
4.5
3.1
4.0
4.4
pmol/l
2.51
102
189
118
255
5.55
53.55
7.0
3.8
24.5
24.1
mmol/l
0.71
113
230
216
759
3.93
52.43
49.3
28.0
1.8
1.3
inr
2.47
16
96
159
481
4.17
47.16
17.0
7.5
1.6
1.4
mmol/l
1.01
148
459
77
125
6.95
46.65
5.6
2.5
3.6
3.7
g/l
0.25
67
117
153
457
4.18
46.09
2.9
2.9
64.3
66.1
g/l
1.92
144
410
163
512
4.03
45.76
7.0
3.6
2.0
2.0
mmol/l
0.06
143
409
163
514
4.01
45.48
7.0
3.6
5.9
5.8
kpa
0.56
158
498
281
1281
3.30
43.90
3.8
2.2
3.5
3.1
mg/l
1.01
248
1087
214
836
3.46
42.94
7.4
1.9
33.3
29.9
s
8.72
209
810
91
191
5.46
42.24
5.0
2.2
2446.3
771.5
ug/l
0.47
86
180
350
1846
3.24
42.10
5.3
2.7
173.7
164.5
ug/l
0.27
331
1668
77
144
6.01
40.41
2.9
3.0
0.8
0.9
nmol/l
0.13
57
113
49
55
9.63
40.38
1.5
1.2
1.2
2.6
u/ml
0.53
17
18
171
609
3.56
39.26
11.7
4.0
266.2
246.6
u/l
0.92
163
571
47
52
9.74
39.13
1.5
1.1
—
—
—
0
0
233
1005
3.20
39.07
9.9
4.0
718.6
295.0
ng/l
0.74
228
843
108
283
4.46
38.27
20.3
10.9
24.3
24.6
mmol/l
0.30
103
266
48
59
8.78
36.84
1.5
1.2
4.7
8.2
u/ml
0.42
23
27
56
85
7.18
35.91
12.0
6.6
524.8
217.0
iu/ml
0.44
16
14
95
250
4.35
33.27
2.0
1.9
1.6
1.5
g/l
0.03
81
224
384
2332
2.89
32.49
16.8
6.1
1.2
1.2
mmol/l
8.48
366
2096
405
2542
2.94
31.95
16.8
6.8
1.2
1.2
mmol/l
8.00
357
2144
166
650
3.17
31.94
16.0
7.7
5.0
5.1
kpa
0.63
157
624
166
650
3.17
31.94
16.0
7.7
11.0
11.8
kpa
1.46
158
626
46
65
7.60
31.37
1.5
1.4
113.3
101.9
u/ml
—
6
10
165
650
3.15
31.36
15.8
7.8
0.2
1.2
mmol/l
2.24
130
511
36
38
10.03
30.91
1.1
1.1
—
—
—
0
0
71
158
4.98
30.54
2.9
2.6
0.0
0.0
g/l
0.06
65
142
68
146
5.14
30.49
3.0
2.6
0.0
0.0
g/l
0.00
62
132
68
149
5.03
29.76
3.0
2.6
0.0
0.0
g/l
0.00
62
133
126
437
3.40
29.42
6.4
2.8
4.4
4.4
kpa
0.08
121
422
74
177
4.64
29.14
3.1
2.6
0.8
1.4
g/l
0.51
66
151
28
22
13.32
29.06
1.4
1.1
—
—
—
0
0
342
2042
2.63
28.46
9.9
4.0
81.6
63.5
ng/l
0.35
309
1576
44
66
7.13
28.43
1.9
1.3
9861.8
43986.2
e6/l
1.04
31
39
71
168
4.67
28.31
2.9
2.4
34.8
37.2
g/l
1.92
63
139
196
895
2.79
28.07
2.6
1.8
—
—
—
0
0
241
1223
2.65
27.98
8.5
4.0
65.5
86.4
%
22.55
233
1194
154
620
3.02
27.83
2.5
1.7
—
—
—
0
0
155
627
3.01
27.77
2.6
1.8
—
—
—
0
0
73
181
4.47
27.44
4.3
3.8
48.7
53.1
mg/l
0.09
66
146
73
181
4.47
27.44
4.3
3.8
59.9
96.7
mg/l
0.48
66
144
113
393
3.33
26.06
5.6
3.8
127.1
90.0
ng/l
3.10
107
346
44
74
6.35
25.49
1.9
1.3
686.1
1716.4
e6/l
2.01
35
51
73
192
4.20
25.36
2.9
2.4
10.3
10.9
g/l
0.46
65
159
70
179
4.31
25.24
4.4
3.7
1.1
2.4
ratio
—
5
14
142
575
2.94
25.15
2.8
2.7
11.0
9.3
umol/l
0.60
126
506
44
75
6.26
25.15
1.4
1.1
—
—
—
0
0
73
195
4.14
24.83
2.9
2.4
3.3
3.1
g/l
0.69
65
149
43
73
6.28
24.67
1.4
1.1
361.1
275.0
u/ml
0.73
38
40
204
1007
2.58
24.46
9.4
1.7
1.6
1.3
mg/l
0.52
162
793
393
2631
2.51
23.85
14.8
6.4
15.4
11.9
umol/l
8.19
383
2489
74
207
3.95
23.60
2.9
2.3
3.8
3.7
g/l
0.26
65
145
74
207
3.95
23.60
2.9
2.3
—
—
—
0
0
74
207
3.95
23.60
2.9
2.3
7.6
7.3
g/l
0.34
65
151
270
1543
2.40
23.25
4.5
2.1
375.1
271.7
u/l
0.35
257
1451
60
146
4.47
23.01
1.9
1.5
—
—
—
0
0
242
1329
2.40
22.67
4.0
2.7
2380.3
6371.5
umol/l
1.00
210
1128
121
478
2.93
22.20
2.6
2.3
0.2
0.2
g/l
1.30
111
445
104
377
3.14
22.20
1.8
1.6
—
—
—
0
0
253
1446
2.32
21.31
4.6
3.3
0.8
0.6
e6/l
0.45
207
1113
396
2735
2.40
21.24
15.6
8.8
4.9
4.2
e9/l
6.23
350
2404
95
337
3.17
20.97
2.0
1.6
—
—
—
0
0
54
130
4.48
20.96
3.5
2.1
10.9
12.7
mg/l
0.63
49
116
343
2253
2.27
20.36
13.9
5.7
21.3
26.3
%
13.80
326
2089
413
2941
2.39
20.09
14.3
5.1
7.2
6.8
mmol/l
2.11
396
2773
55
139
4.26
20.05
1.6
1.4
—
—
—
0
0
337
2217
2.23
19.67
7.3
4.8
33.4
35.0
g/l
5.32
316
2050
299
1877
2.22
19.59
5.0
3.3
—
—
—
0
0
337
2225
2.22
19.39
13.5
5.5
63.5
58.1
%
13.07
322
2082
87
309
3.13
19.10
2.1
1.4
—
—
—
0
0
66
198
3.63
18.94
3.2
2.1
36.9
39.1
u/l
0.23
50
175
211
1164
2.27
18.84
3.9
2.4
—
—
—
0
0
261
1583
2.17
18.30
4.8
3.4
94.5
121.7
e6/l
0.21
218
1244
52
139
4.01
17.57
3.3
3.2
32.5
33.9
umol/l
0.16
47
112
248
1505
2.13
17.06
3.5
3.4
64.2
34.1
u/l
1.32
234
1423
44
110
4.24
16.24
1.3
1.2
—
—
—
0
0
42
102
4.36
16.09
1.7
1.3
—
—
—
0
0
42
102
4.36
16.09
1.7
1.3
—
—
—
0
0
167
889
2.23
15.83
3.8
2.9
0.9
1.0
e6/l
0.15
100
527
78
291
2.94
15.61
24.3
10.4
—
—
—
0
0
86
340
2.79
15.47
5.0
3.8
1.7
1.8
mmol/l
0.11
65
270
157
833
2.21
14.89
3.9
3.2
1.8
1.7
e6/l
0.15
89
476
41
105
4.12
14.66
4.4
2.3
15.6
16.0
%
0.16
24
55
62
210
3.18
14.64
2.2
3.0
—
—
—
0
0
51
153
3.56
14.59
1.2
1.2
—
—
—
0
0
102
453
2.52
14.51
2.5
2.4
32.9
32.3
u/l
0.08
87
385
416
3173
2.09
14.23
6.4
4.8
29.8
3274.8
e6/l
—
9
58
42
112
3.96
14.22
1.8
1.5
—
—
—
0
0
191
1118
2.05
13.89
3.6
2.6
4.6
4.4
e6/l
0.11
175
989
24
44
5.65
12.68
1.5
1.5
15.5
13.8
u/l
0.46
24
39
36
94
4.02
12.54
1.6
1.8
—
—
—
0
0
239
1557
1.91
12.47
3.5
2.5
58.3
57.3
u/l
0.14
225
1436
26
53
5.09
12.26
1.6
1.6
—
—
—
0
0
41
126
3.42
11.30
1.6
1.7
—
—
—
0
0
44
142
3.27
11.23
4.2
2.9
2.1
1.6
mg/l
2.62
39
128
14
16
8.94
11.15
1.1
1.1
191.8
247.7
iu/ml
0.26
14
16
26
58
4.65
11.06
3.3
3.6
—
—
—
0
0
454
3716
2.00
10.91
17.5
7.8
86.4
80.3
u/l
1.14
439
3467
40
129
3.26
10.23
1.6
1.6
—
—
—
0
0
81
379
2.32
10.13
3.8
3.2
41.5
60.0
ml/min/173m2
4.90
45
167
46
164
2.96
9.94
1.6
1.6
—
145.7
—
0
7
16
25
6.55
9.85
1.3
1.2
—
—
—
0
0
196
1277
1.81
9.70
2.1
1.6
19.0
20.2
nmol/l
0.49
174
1068
24
56
4.43
9.67
2.0
2.7
—
—
—
0
0
99
541
2.00
8.29
5.3
3.4
—
—
—
0
0
35
119
3.07
8.22
4.0
2.2
125.6
129.9
g/l
0.38
28
89
26
74
3.63
8.06
1.9
1.6
—
—
—
0
0
224
1592
1.66
7.75
3.4
3.2
6.7
7.7
mmol/l
3.38
192
1303
234
1682
1.65
7.74
4.8
3.4
2.3
2.4
mmol/l
0.83
193
1444
13
21
6.31
7.74
5.1
2.1
967.8
822.3
u/ml
0.24
13
21
281
2131
1.62
7.40
2.4
2.1
93.5
93.5
pmol/l
0.01
148
1104
50
218
2.41
7.31
6.7
4.1
1.5
1.4
mmol/l
0.18
50
213
291
2233
1.61
7.24
5.8
4.1
—
—
—
0
0
406
3380
1.66
7.22
5.9
3.6
15.8
15.0
pmol/l
5.24
383
2992
250
1856
1.61
7.10
3.0
2.2
75.4
78.5
nmol/l
0.90
224
1612
11
8
13.98
6.91
1.0
1.0
—
—
—
0
0
226
1647
1.61
6.88
4.3
4.1
27.5
8.6
mg/mmol
2.73
173
1059
36
138
2.71
6.85
1.3
1.5
—
—
—
0
0
10
15
6.77
6.33
2.3
1.3
8.3
10.0
ug/l
—
10
15
13
26
5.09
6.25
1.1
1.5
—
—
—
0
0
13
26
5.09
6.25
1.1
1.5
—
—
—
0
0
407
3449
1.60
6.16
7.1
4.2
17.9
13.5
mm/h
4.49
384
3142
23
73
3.24
6.08
1.3
1.3
—
—
—
0
0
51
245
2.19
5.98
2.3
1.9
1.5
2.6
ug/l
0.39
46
215
11
21
5.32
5.54
1.0
1.0
—
—
—
0
0
20
63
3.25
5.36
1.5
1.9
—
—
—
0
0
25
91
2.83
5.27
4.2
3.7
60.3
59.2
%
0.14
25
91
24
87
2.83
5.10
2.8
3.2
3.9
4.5
e9/l
0.61
24
87
14
36
3.96
5.01
1.8
1.7
—
—
—
0
0
20
66
3.10
4.99
1.5
1.9
—
—
—
0
0
17
51
3.40
4.92
6.7
2.5
—
—
—
0
0
65
373
1.84
4.67
10.6
6.8
23.8
24.5
mmol/l
0.66
60
348
73
436
1.77
4.60
2.5
1.9
417.8
383.0
nmol/l
0.36
68
397
148
1058
1.53
4.59
2.2
1.8
1272.3
1174.9
nmol/l
0.57
117
806
23
90
2.62
4.27
1.9
1.6
1.5
5.8
iu/l
—
7
25
21
79
2.72
4.20
1.6
1.6
—
—
—
0
0
24
97
2.54
4.18
1.6
1.6
—
—
—
0
0
7
7
10.10
4.02
5.7
6.4
4.4
7.3
mmol/l
—
7
7
9
15
6.08
3.83
2.0
1.3
253.8
209.4
u/l
—
9
15
500
4610
1.59
3.79
47.4
16.2
25.1
26.6
mg/l
0.59
466
3739
21
84
2.56
3.75
1.6
1.6
—
—
—
0
0
30
142
2.17
3.71
1.4
1.2
—
—
—
0
0
19
74
2.62
3.58
1.7
1.6
—
—
—
0
0
29
141
2.11
3.38
1.4
1.2
—
—
—
0
0
12
37
3.29
3.36
1.2
1.2
—
—
—
0
0
12
37
3.29
3.36
1.2
1.2
—
—
—
0
0
14
48
2.96
3.32
1.1
1.3
—
—
—
0
0
12
38
3.20
3.23
1.2
1.2
—
—
—
0
0
12
38
3.20
3.23
1.2
1.2
—
—
—
0
0
12
38
3.20
3.23
1.2
1.2
—
—
—
0
0
10
28
3.62
3.21
1.0
1.0
—
—
—
0
0
30
152
2.03
3.15
1.4
1.4
—
—
—
0
0
130
975
1.43
3.08
3.0
3.2
2.5
2.5
mmol/l
1.01
102
853
17
68
2.55
3.06
1.1
1.2
—
38.6
—
0
6
91
639
1.50
3.02
24.0
8.3
—
—
—
0
0
411
3708
1.37
2.96
56.7
19.8
14.9
13.8
%
24.55
403
3635
27
136
2.03
2.90
1.3
1.5
0.0
0.1
iu/ml
—
8
34
7
13
5.44
2.87
1.0
1.3
—
—
—
0
0
35
195
1.85
2.82
1.8
1.6
—
—
—
0
0
114
848
1.43
2.81
1.2
1.2
1.3
1.2
u/ml
0.05
29
214
9
24
3.79
2.68
2.0
2.1
—
—
—
0
0
12
43
2.83
2.66
1.4
1.1
1.9
1.5
nmol/l
0.45
12
37
10
32
3.16
2.65
1.7
1.6
—
—
—
0
0
19
87
2.22
2.60
1.4
1.1
—
—
—
0
0
14
56
2.54
2.54
1.6
1.8
—
—
—
0
0
14
56
2.54
2.54
1.6
1.8
—
—
—
0
0
14
56
2.54
2.54
1.6
1.8
—
—
—
0
0
37
218
1.74
2.51
1.9
1.7
—
—
—
0
0
448
4147
1.35
2.39
6.9
4.5
2.2
2.0
mu/l
2.29
424
3705
7
17
4.15
2.36
5.7
4.9
—
—
—
0
0
68
475
1.49
2.33
1.9
1.8
1.6
1.6
%
0.21
57
407
14
59
2.41
2.31
1.7
1.6
—
—
—
0
0
32
186
1.76
2.29
1.3
1.2
—
—
—
0
0
9
29
3.14
2.23
1.9
1.7
—
—
—
0
0
8
24
3.36
2.18
1.9
1.7
—
—
—
0
0
12
262
0.45
2.11
1.5
1.8
—
—
—
0
0
264
2304
1.27
2.11
6.5
5.3
0.0
0.0
estimate
0.00
57
418
8
25
3.23
2.10
1.9
1.7
—
—
—
0
0
14
66
2.15
1.83
1.0
1.0
—
—
—
0
0
15
73
2.08
1.82
1.6
2.0
32.4
33.2
pg
0.27
15
73
432
4034
1.27
1.80
52.9
17.5
38.4
39.6
%
2.00
295
2626
260
2301
1.23
1.75
5.0
4.0
0.0
0.0
estimate
0.00
55
422
8
30
2.69
1.73
6.4
2.9
—
—
—
0
0
22
128
1.75
1.62
1.3
2.1
—
—
—
0
0
5
14
3.59
1.62
1.0
1.1
—
—
—
0
0
318
2898
1.21
1.54
4.0
3.2
91.2
56.1
u/l
4.49
295
2665
261
2338
1.21
1.49
5.0
4.0
0.0
0.0
estimate
0.00
53
407
9
40
2.27
1.40
1.0
1.5
—
—
—
0
0
17
96
1.79
1.40
1.2
1.3
—
—
—
0
0
11
53
2.10
1.39
2.2
1.5
—
—
—
0
0
6
23
2.62
1.37
1.0
1.3
—
—
—
0
0
31
211
1.50
1.28
1.2
1.2
32.1
132.8
iu/ml
—
9
72
14
77
1.84
1.26
1.1
1.1
—
1.9
—
0
8
5
19
2.65
1.22
2.8
1.4
0.1
0.2
nmol/l
—
5
11
8
37
2.18
1.22
1.4
1.3
—
53.3
—
0
6
456
4349
1.22
1.21
46.1
15.2
63.0
75.8
ml/min/173m2
23.26
423
3613
6
26
2.32
1.19
3.8
1.8
—
—
—
0
0
6
26
2.32
1.19
1.0
3.7
146.3
78.7
nmol/l
—
6
26
165
1871
0.84
1.17
3.9
4.5
21.5
21.3
%
0.07
55
920
147
1278
1.20
1.12
5.9
4.3
0.0
0.0
estimate
0.00
56
396
14
82
1.72
1.06
1.1
1.1
—
—
—
0
0
7
35
2.01
1.00
1.1
1.2
—
—
—
0
0
5
23
2.18
0.98
1.0
2.1
—
—
—
0
0
5
23
2.18
0.98
1.0
2.1
—
—
—
0
0
5
23
2.18
0.98
1.0
2.1
—
—
—
0
0
502
4863
1.23
0.98
64.5
19.3
139.0
139.6
mmol/l
5.18
493
4725
458
4402
1.19
0.95
8.0
6.4
44.3
40.7
mmol/mol
8.64
433
4040
14
85
1.66
0.95
1.0
1.2
—
—
—
0
0
6
119
0.50
0.94
4.2
1.5
—
—
—
0
0
502
4877
1.21
0.85
65.0
19.4
4.1
4.0
mmol/l
6.99
491
4735
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
20
138
1.47
0.82
2.0
1.7
8203.6
17856.5
e6/l
1.02
14
100
8
47
1.71
0.81
3.4
1.4
—
—
—
0
0
0
26
0.00
0.78
0.0
1.1
—
—
—
0
0
27
359
0.74
0.78
1.2
1.3
—
—
—
0
0
112
1265
0.86
0.75
1.5
1.7
1.5
1.3
mmol/l
1.61
99
1032
9
54
1.68
0.75
1.0
1.1
—
—
—
0
0
80
690
1.18
0.69
1.3
1.3
40.5
35.8
iu/ml
0.14
38
214
7
43
1.64
0.67
2.9
2.4
—
131.3
—
0
6
5
28
1.79
0.66
1.0
1.9
—
—
—
0
0
5
28
1.79
0.66
1.0
1.9
—
—
—
0
0
5
28
1.79
0.66
1.0
1.9
—
—
—
0
0
5
28
1.79
0.66
1.0
1.9
—
—
—
0
0
29
225
1.30
0.64
1.3
3.5
16401.9
6244.2
u/ml
0.26
22
190
5
29
1.73
0.64
1.2
1.2
—
—
—
0
0
5
29
1.73
0.64
1.2
1.2
—
—
—
0
0
15
104
1.45
0.63
1.1
1.1
—
—
—
0
0
54
636
0.83
0.60
6.7
4.8
33.0
31.8
%
0.44
42
429
448
4351
1.13
0.58
5.9
4.2
1.4
1.3
mmol/l
1.06
419
3930
252
2378
1.11
0.56
2.9
2.4
—
—
—
0
0
220
2335
0.91
0.53
3.8
5.2
2.0
3.0
ug/l
1.58
186
2079
12
83
1.46
0.52
1.2
1.8
588.3
282.0
mu/l
0.63
12
77
6
41
1.47
0.50
1.5
1.0
—
—
—
0
0
123
1330
0.90
0.43
2.6
3.1
0.6
0.8
ug/l
1.77
79
894
5
31
1.62
0.43
1.8
2.7
—
—
—
0
0
498
4894
1.12
0.41
23.1
11.1
31.9
26.2
u/l
1.06
484
4702
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.2
—
—
—
0
0
5
34
1.47
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.32
0.39
1.1
1.4
—
—
—
0
0
20
160
1.26
0.39
1.1
1.0
—
—
—
0
0
25
292
0.85
0.30
2.2
2.6
—
21.9
—
0
12
8
108
0.74
0.29
1.9
3.5
17.9
430.0
u/ml
—
8
102
9
116
0.77
0.27
1.8
2.1
228.9
227.3
pmol/l
—
9
106
8
64
1.25
0.27
1.3
1.5
—
—
—
0
0
8
65
1.23
0.27
1.3
1.5
—
—
—
0
0
8
65
1.23
0.27
1.3
1.5
—
—
—
0
0
8
65
1.23
0.27
1.3
1.5
—
—
—
0
0
8
65
1.23
0.27
1.3
1.5
—
—
—
0
0
8
66
1.22
0.27
1.3
1.5
—
—
—
0
0
456
4493
1.07
0.25
6.1
4.7
1.2
1.4
mmol/l
23.19
426
4081
57
523
1.10
0.25
1.4
1.4
—
—
—
0
0
70
649
1.09
0.24
1.1
1.3
13.1
11.1
u/ml
0.10
28
229
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
54
578
0.93
0.18
2.1
4.2
21.7
32.7
ug/l
0.23
48
492
18
157
1.15
0.17
1.8
2.5
53.9
70.2
ug/min
—
8
91
5
66
0.76
0.17
1.0
3.5
12.0
28.9
u/ml
—
5
66
175
1802
0.96
0.16
5.7
4.3
—
—
—
0
0
502
5057
0.95
0.15
66.7
23.9
129.8
135.3
g/l
9.16
493
4959
457
4526
1.04
0.15
6.1
4.8
3.9
4.5
mmol/l
24.68
436
4147
10
116
0.86
0.12
1.2
1.3
—
—
—
0
0
109
1123
0.96
0.11
2.0
1.8
457.5
4324754.4
pmol/l
0.50
87
925
10
112
0.89
0.07
1.2
1.4
—
—
—
0
0
13
118
1.10
0.07
1.6
1.6
—
—
—
0
0
451
4531
0.98
0.05
5.9
5.0
6.4
6.1
mmol/l
4.03
420
4077
25
260
0.96
0.03
1.2
1.4
—
45.6
—
0
16
465
4640
1.01
0.02
6.4
5.3
2.3
2.6
mmol/l
14.73
437
4215
16
156
1.03
0.00
2.0
1.9
32.8
41.8
nmol/l
1.31
16
147
28
285
0.98
0.00
3.6
3.0
0.2
0.3
e6/l
0.08
28
279
18
183
0.98
0.00
1.2
1.6
—
—
—
0
0
20
203
0.98
0.00
1.2
1.7
—
—
—
0
0
104
1043
1.00
0.00
5.7
4.5
1.0
1.0
kg/l
—
8
155
16
159
1.01
0.00
1.3
3.2
51.3
58.6
u/ml
0.10
16
152
0
6
0.00
0.00
0.0
1.0
—
3.3
—
0
6
0
6
0.00
0.00
0.0
1.0
—
22.3
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
3.4
—
83.8
—
0
8
5
54
0.93
0.00
1.4
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
2.5
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
1.5
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
5
55
0.91
0.00
1.0
3.2
6.9
6.9
nmol/l
—
5
55
0
5
0.00
0.00
0.0
2.8
—
0.4
—
0
5
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_HEARTFAIL_AND_HYPERTCARDIOM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_AND_HYPERTCARDIOM | 2.312 [1.99, 2.68] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.234 |
During the follow-up period (1.1.1998 — 31.12.2019), 625 out of 1166 females with I9_HEARTFAIL_AND_HYPERTCARDIOM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HEARTFAIL_AND_HYPERTCARDIOM | 2.417 [2.08, 2.81] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 885 out of 1729 males with I9_HEARTFAIL_AND_HYPERTCARDIOM died.
Mortality risk
Mortality risk for people of age
years, who have I9_HEARTFAIL_AND_HYPERTCARDIOM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.397% |
| 5 | 1.164% | 2.836% |
| 10 | 3.2% | 7.472% |
| 15 | 6.537% | 13.271% |
| 20 | 10.87% | 22.039% |
Relationships between endpoints
↥Index endpoint: I9_HEARTFAIL_AND_HYPERTCARDIOM – Heart failure and hypertrophic cardiomyopathy
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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