hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1436 |
4. Check minimum number of eventsNone |
1436 |
5. Include endpointsNone |
1436 |
6. Filter based on genotype QC (FinnGen only) |
1436 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF3
Hypertrophic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9589 | 3813 | 5697 |
| Only index persons | 8026 | 3216 | 4810 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.11 | 0.16 |
| Only index persons | 0.16 | 0.12 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 62.13 | 65.75 | 59.66 |
| Only index persons | 61.60 | 64.96 | 59.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1436 | 577 | 859 |
| Unadjusted period prevalence (%) | 0.31 | 0.20 | 0.38 |
| Median age at first event (years) | 60.47 | 59.78 | 60.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1301
- Matched controls
- 13009
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
4503599627370496.0
323.0
992
*
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
10179.4
323.0
590
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
34.8
273.7
361
142
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
8.9
258.9
700
1500
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
44.7
216.4
268
75
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
11.8
189.1
379
437
XF404
NOMESCO Finland
Ambulatory ECG
9.5
183.6
423
628
C07AB07
ATC
bisoprolol; oral
5.5
168.6
988
4721
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.4
156.6
633
1956
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
12.0
156.6
306
324
201
Kela drug reimbursment
Chronic cardiac insufficiency
12.0
147.9
288
300
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.2
146.3
601
1855
C03CA01
ATC
furosemide; systemic
4.6
139.0
689
2548
I50.9
ICD-10 Finland
Heart failure, unspecified
5.8
130.3
437
1041
C03DA01
ATC
spironolactone; oral
6.6
128.8
377
754
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
11.7
127.5
250
259
I47.2
ICD-10 Finland
Ventricular tachycardia
22.2
123.0
183
95
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
31.8
119.7
160
57
207
Kela drug reimbursment
Chronic arrhythmias
5.1
119.0
451
1217
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.3
117.0
584
2075
B01AA03
ATC
warfarin; systemic
4.4
113.9
531
1758
C01BD01
ATC
amiodarone; systemic
12.0
99.5
190
182
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
23.7
87.7
127
59
I50.0
ICD-10 Finland
Congestive heart failure
6.3
86.6
253
480
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
74.6
85.7
97
14
I50.1
ICD-10 Finland
Left ventricular failure
8.0
81.3
197
285
XF402
NOMESCO Finland
ECG with work load test
4.5
79.2
321
876
TFP20
NOMESCO Finland
Cardiodefibrillation
5.2
74.3
256
585
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
40.6
72.4
91
24
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.8
72.3
270
672
AN1
HP
Coronary angiography
4.1
71.9
321
952
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
71.0
760
4276
I44.2
ICD-10 Finland
Atrioventricular block, complete
10.8
68.2
136
139
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
65.3
358
1252
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
6.7
64.6
176
298
Z2221
NOMESCO Finland
Medical doctor
2.9
61.6
513
2397
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
46.0
60.5
74
17
C09AA05
ATC
ramipril; oral
2.8
58.4
486
2251
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.2
57.6
195
429
XF400
NOMESCO Finland
ECG with 12 standard connections
3.2
56.6
358
1375
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.3
54.0
324
1189
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
6.4
52.0
145
251
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.3
49.0
287
1029
GD1LA
NOMESCO Finland
GD
11.8
48.4
91
82
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.4
47.1
184
466
C01AA05
ATC
digoxin; systemic
3.9
44.5
204
597
Z3231
NOMESCO Finland
Registered nurse
2.5
43.4
472
2450
Z94.1
ICD-10 Finland
Heart transplant status
53.0
42.9
51
10
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
12.5
42.2
77
65
R06.0
ICD-10 Finland
Dyspnoea
2.4
39.1
410
2066
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
19.0
39.1
60
33
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
38.5
589
3553
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
37.4
37.1
47
13
ZXE00
NOMESCO Finland
One hour or less
2.2
36.7
589
3605
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
17.3
36.6
58
35
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
13.1
36.6
65
52
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
367.0
36.2
36
*
R4110
NOMESCO Finland
Physiotherapy
2.3
35.7
430
2301
WX892
NOMESCO Finland
Monitored bed care
3.6
35.6
175
539
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.4
35.4
395
2033
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
11.0
34.7
67
64
I42.8
ICD-10 Finland
Other cardiomyopathies
21.2
34.6
51
25
C09DX04
ATC
valsartan and sacubitril; oral
18.6
33.8
52
29
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.1
33.4
139
370
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
18.9
33.3
51
28
XF640
NOMESCO Finland
NA
6.0
33.0
94
166
C07AA07
ATC
sotalol; systemic
4.7
32.7
116
264
4251A
ICD-9 Finland
Cardiomyopathy, Hypertrophic obstructive cardiomyopathy
324.6
32.0
32
*
C07AB02
ATC
metoprolol; systemic
2.3
31.4
349
1774
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
71.7
31.0
35
5
I42
ICD-10 Finland
Cardiomyopathy
71.7
31.0
35
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
30.4
545
3412
I49.5
ICD-10 Finland
Sick sinus syndrome
4.8
30.3
105
233
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.6
30.2
110
257
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
13.5
29.8
52
40
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
4.6
29.5
106
244
B01AF02
ATC
apixaban; oral
2.9
29.0
194
741
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
25.7
28.9
40
16
ZXD05
NOMESCO Finland
Urgent procedure
2.1
28.9
451
2652
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
28.7
407
2300
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.9
28.7
196
758
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
56.3
28.2
33
6
WX740
NOMESCO Finland
Nitrogen oxide therapy
65.5
28.0
32
5
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
27.9
278
1330
AP4
HP
Myocardial biopsy
102.3
27.8
30
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
27.0
333
1761
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.6
26.9
127
376
AS8
HP
Physiological arrhythmia pacemaker insertionDDD (R) S
33.8
25.6
33
10
127
Kela drug reimbursment
Transplant complication
7.7
25.6
60
81
TFJ02
NOMESCO Finland
Muscle biopsy of heart
29.0
25.5
34
12
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
9.3
25.4
53
59
L04AA06
ATC
mycophenolic acid; systemic
7.3
25.4
62
89
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
25.3
367
2074
TFP34
NOMESCO Finland
Electrophysiological investigation
5.0
25.1
82
171
81
HP
Angiography of the heart and coronary arteries
3.2
24.8
139
468
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
132.5
24.7
26
*
R55
ICD-10 Finland
Syncope and collapse
2.6
24.6
190
789
I47.1
ICD-10 Finland
Supraventricular tachycardia
4.2
24.3
95
238
WX872
NOMESCO Finland
Intensive care
3.7
24.2
112
326
71
HP
Electrophysiological Special Examination
16.3
23.7
38
24
K78
ICPC
Atrial fibrillation/flutter
2.9
23.7
153
568
A12BA01
ATC
potassium chloride; oral
3.9
23.6
102
280
M04AA01
ATC
allopurinol; systemic
2.4
23.4
230
1084
I49.3
ICD-10 Finland
Ventricular premature depolarization
3.2
23.3
127
420
Z3226
NOMESCO Finland
Physiotherapist
2.1
23.2
294
1561
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
5.7
22.6
66
121
C01BA03
ATC
disopyramide; systemic
12.1
22.6
41
35
TK810
NOMESCO Finland
Hemofiltration
15.2
22.5
37
25
TK800
NOMESCO Finland
Hemodialysis
5.7
22.1
64
116
I50
ICD-10 Finland
Heart failure
4.5
22.0
80
187
FN2EG
NOMESCO Finland
Catheter-based alcohol septal ablation
+∞
21.9
21
*
AS4
HP
Physiological pacemaker insertion DDD (R)
7.9
21.4
49
64
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.2
21.3
119
397
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.4
21.1
107
335
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
9.1
20.9
44
50
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
20.7
180
791
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
9.6
20.7
42
45
7AX01
NOMESCO Finland
NA
111.8
20.6
22
*
FPJ22
NOMESCO Finland
Revision of cardioverter-defibrillator with atrial and ventricular electrodes
36.4
19.9
25
7
FLE10
NOMESCO Finland
Myotomy or myectomy of left ventricle for outlet obstruction
+∞
19.8
19
*
TFP35
NOMESCO Finland
Electroanatomical mapping
7.3
19.7
47
66
C07AG02
ATC
carvedilol; oral
3.0
19.4
116
408
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
22.9
19.1
27
12
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
19.0
220
1109
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
19.0
114
402
K84
ICPC
Heart disease other
4.5
18.8
67
154
ATX
HP
Other pacemaker replacement or related action, such as cord removal or replacement
39.0
18.6
23
6
C08DA01
ATC
verapamil; systemic
3.7
18.6
82
230
XFE00
NOMESCO Finland
Epicardial ultrasonography
4.7
18.5
64
143
AQ1
HP
Conventional electrophysiological examination
7.5
18.3
43
59
I48.1
ICD-10 Finland
Persistent atrial fibrillation
4.6
18.0
63
142
73
HP
Initial pacemaker installation
12.1
17.8
32
27
I48.2
ICD-10 Finland
Chronic atrial fibrillation
4.5
17.7
63
145
Z82.7
ICD-10 Finland
Family history of congenital malformations, deformations and chromosomal abnormalities
37.3
17.6
22
6
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
17.6
139
580
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
5.0
17.5
56
115
ZX120
NOMESCO Finland
Intravenous
2.4
17.5
155
687
AP2
HP
Catheterization of the right side of the heart
24.4
17.3
24
10
FPE40
NOMESCO Finland
Replacement of transvenous cardiac pacemaker electrode
17.7
17.0
26
15
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.9
16.8
71
192
Z2446
NOMESCO Finland
Social worker
2.8
16.5
112
427
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
16.5
280
1640
AP1
HP
Catheterization of the left side of the heart
5.4
16.4
49
93
1CX08
NOMESCO Finland
NA
13.0
16.2
28
22
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
4.4
15.9
58
137
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
15.9
339
2142
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
15.9
142
631
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
15.7
233
1295
R00.1
ICD-10 Finland
Bradycardia, unspecified
3.9
15.7
65
173
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
86.1
15.6
17
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
5.0
15.5
50
104
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.9
15.5
99
364
ZX108
NOMESCO Finland
Inhalation
8.0
14.9
33
42
I41.8*D86.8
ICD-10 Finland
Sarcoid myocarditis
32.1
14.8
19
6
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
14.7
360
2366
AK1
HP
HTX (heart transplant)
+∞
14.6
14
*
G04BE03
ATC
sildenafil; oral
5.1
14.4
45
91
AP3
HP
Catheterization of the right and left side of the heart
17.2
14.3
22
13
XFP02
NOMESCO Finland
NA
43.0
14.1
17
*
3A064
NOMESCO Finland
NA
15.9
13.9
22
14
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
5.5
13.7
40
75
I42.5
ICD-10 Finland
Other restrictive cardiomyopathy
75.9
13.6
15
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
13.5
87
322
C10AA01
ATC
simvastatin; oral
1.6
13.4
576
4372
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
5.8
13.4
37
65
FXL00
NOMESCO Finland
Insertion and use of extra-, para- or intracorporeal VAD
40.5
13.2
16
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.2
13.1
70
229
74
HP
Initial installation of the atrial pacemaker
15.2
13.1
21
14
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.0
13.1
77
270
A11CC03
ATC
alfacalcidol; systemic
4.0
13.0
52
135
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
8.9
13.0
27
31
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.9
13.0
53
140
E85.9
ICD-10 Finland
Amyloidosis, unspecified
28.7
13.0
17
6
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
28.7
13.0
17
6
XF600
NOMESCO Finland
Bloodpressure measurement
2.5
13.0
102
425
AA1AD
NOMESCO Finland
CT of head and brain
1.7
12.9
317
2075
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
12.8
94
375
C01DA14
ATC
isosorbide mononitrate; oral
1.9
12.7
217
1266
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
12.7
149
752
TFP52
NOMESCO Finland
Ablation treatment of ventricular tachycardia due to structural heart defect
+∞
12.5
12
*
742
NOMESCO Finland
NA
24.6
12.5
17
7
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
13.3
12.4
21
16
M10.9
ICD-10 Finland
Gout, unspecified
2.4
12.4
108
475
C03AA03
ATC
hydrochlorothiazide; oral
2.1
12.4
139
689
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
11.8
12.3
22
19
TKC20
NOMESCO Finland
Catheterisation of bladder
2.3
12.1
111
502
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
21.5
12.0
17
8
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
21.5
12.0
17
8
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3.3
11.9
60
189
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
9.7
11.8
23
24
205
Kela drug reimbursment
Chronic hypertension
1.6
11.7
377
2641
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.7
11.7
255
1604
FPJ21
NOMESCO Finland
Revision of cardioverter-defibrillator with ventricular electrode
65.5
11.6
13
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.0
11.5
31
53
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.3
11.4
57
179
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
11.3
183
1045
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
11.3
447
3288
B01AB05
ATC
enoxaparin; parenteral
1.6
11.3
375
2643
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
35.3
11.3
14
*
K77
ICPC
Heart failure
4.1
11.3
43
108
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.8
11.2
47
128
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
11.2
114
541
5AB14
NOMESCO Finland
NA
20.2
11.1
16
8
E05.89
ICD-10 Finland
Other thyrotoxicosis
20.2
11.1
16
8
3AC01
NOMESCO Finland
NA
5.6
11.1
31
56
R53
ICD-10 Finland
Malaise and fatigue
1.7
11.0
250
1589
C09AA04
ATC
perindopril; oral
2.6
10.9
81
328
J01CA04
ATC
amoxicillin; systemic
1.5
10.8
971
8525
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
21.7
10.7
15
7
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.5
10.6
85
359
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
10.5
60
206
FM1LE
NOMESCO Finland
Combined ultrasound and EKG examination of heart with tolerance test
14.3
10.5
17
12
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
4.8
10.5
34
73
I45.9
ICD-10 Finland
Conduction disorder, unspecified
5.7
10.4
29
52
I42.4
ICD-10 Finland
Endocardial fibroelastosis
110.9
10.4
11
*
APS
HP
Ventricular septal alcohol ablation (septic vascular embolization)
+∞
10.4
10
*
C10AA05
ATC
atorvastatin; oral
1.5
10.4
495
3782
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
12.1
10.4
18
15
XF622
NOMESCO Finland
Measurement of minute volume of heart
18.9
10.3
15
8
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
10.2
218
1357
B01AE07
ATC
dabigatran etexilate; oral
2.8
10.2
65
241
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.6
10.2
44
124
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.3
10.1
92
413
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.7
10.0
33
72
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
10.1
10.0
19
19
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
40.4
10.0
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
9.9
362
2598
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
9.9
116
585
I20.00
ICD-10 Finland
Unstable angina
2.9
9.8
57
199
G47.3
ICD-10 Finland
Sleep apnoea
1.6
9.8
273
1833
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
9.8
731
6100
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
9.7
65
248
R02
ICPC
Shortness of breath/dyspnoea
1.9
9.7
154
875
I41.8
ICD-10 Finland
Myocarditis in other diseases classified elsewhere
55.4
9.7
11
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.4
9.6
79
339
N18.8
ICD-10 Finland
Other chronic renal failure
3.2
9.6
48
152
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
9.6
87
393
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
9.6
72
295
XF409
NOMESCO Finland
Other special ECG
10.1
9.5
18
18
H02AB06
ATC
prednisolone; systemic
1.5
9.4
550
4355
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
100.7
9.4
10
*
63
HP
Cardiac muscle biopsy
100.7
9.4
10
*
FM1JR
NOMESCO Finland
Heart, extensive metabolic PET with CT
17.7
9.4
14
8
Z82.4
ICD-10 Finland
Family history of ischaemic heart disease and other diseases of the circulatory system
17.7
9.4
14
8
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.9
9.4
139
769
42500
ICD-8 Finland
Cardiomyopathy, Stenosis subaortae hypertrophicans
+∞
9.4
9
*
H03BB01
ATC
carbimazole; oral
2.9
9.2
55
197
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.5
9.1
68
276
FPJ00
NOMESCO Finland
Revision of pacemaker pulse generator or electrode
11.6
9.1
16
14
ASB
HP
Insertion of a biventricular physiological pacemaker DDD (R)
36.9
9.0
11
*
FPG04
NOMESCO Finland
Insertion of internal defibrillator, atrial and chamber electrode
36.9
9.0
11
*
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
9.0
258
1740
WX002
NOMESCO Finland
Sedation and analgesia
1.6
9.0
249
1665
FPG42
NOMESCO Finland
Replacement of electrode(s) in transvenous cardioverter-defibrillator
24.2
8.9
12
5
42509
ICD-8 Finland
Cardiomyopathy, Unspecified
24.2
8.9
12
5
ZXA05
NOMESCO Finland
Left side
1.5
8.9
314
2227
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
4.1
8.9
33
82
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.4
8.8
74
322
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.9
8.8
128
701
Z31.5
ICD-10 Finland
Genetic counselling
2.8
8.8
56
209
K80
ICPC
Cardiac arrhythmia NOS
2.1
8.7
95
465
FM1CD
NOMESCO Finland
Very extensive CT of heart
14.1
8.7
14
10
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
50.3
8.7
10
*
PD5BD
NOMESCO Finland
Extensive CT of aorta
3.7
8.7
36
99
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
7.7
8.7
19
25
C08DB01
ATC
diltiazem; oral
2.3
8.6
80
364
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
4.7
8.6
28
61
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
9.0
8.5
17
19
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
4.6
8.5
28
62
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
27.7
8.5
11
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.4
8.5
73
319
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
3.8
8.5
34
91
FPH20
NOMESCO Finland
Removal of epicardial pacemaker or cardioverter-defibrillator
90.6
8.4
9
*
XX3BW
NOMESCO Finland
NA
90.6
8.4
9
*
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.1
8.4
99
500
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.1
8.4
45
151
C01BB02
ATC
mexiletine; systemic
12.8
8.4
14
11
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
6.8
8.4
20
30
42508
ICD-8 Finland
Cardiomyopathy, Alia definita
+∞
8.3
8
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
5.9
8.3
22
38
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.6
8.3
57
223
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.9
8.3
32
83
C08CA02
ATC
felodipine; oral
1.9
8.1
125
701
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
8.2
8.1
17
21
I44.0
ICD-10 Finland
Atrioventricular block, first degree
4.1
8.1
30
75
TK830
NOMESCO Finland
Ultrafiltration
33.6
8.1
10
*
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
6.9
8.1
19
28
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.2
8.0
81
384
A46
ICD-10 Finland
Erysipelas
1.7
8.0
181
1144
E87.5
ICD-10 Finland
Hyperkalaemia
4.3
8.0
28
66
ZX197
NOMESCO Finland
NA
22.2
8.0
11
5
I49.8
ICD-10 Finland
Other specified cardiac arrhythmias
3.1
8.0
41
134
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.9
8.0
47
168
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
7.8
7.9
17
22
A02BC02
ATC
pantoprazole; systemic
1.4
7.9
763
6553
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
7.8
113
620
J01FF01
ATC
clindamycin; systemic
1.5
7.8
316
2301
Z2445
NOMESCO Finland
Psychologist
2.8
7.7
49
181
I34.1
ICD-10 Finland
Mitral (valve) prolapse
2.9
7.7
45
159
N19
ICD-10 Finland
Unspecified kidney failure
2.7
7.7
51
196
I24.0
ICD-10 Finland
Coronary thrombosis not resulting in myocardial infarction
45.2
7.7
9
*
XF645
NOMESCO Finland
Heart ultrasound examination with load test
45.2
7.7
9
*
XF406
NOMESCO Finland
High resolution ECG
45.2
7.7
9
*
WX402
NOMESCO Finland
General anaesthesia
1.6
7.7
187
1207
C09AA02
ATC
enalapril; systemic
1.5
7.6
253
1766
R04.0
ICD-10 Finland
Epistaxis
1.9
7.6
104
561
250
Kela drug reimbursment
NA
25.2
7.6
10
*
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
5.5
7.5
21
39
EBA10
NOMESCO Finland
Surgical removal of tooth
1.8
7.5
125
718
FXM00
NOMESCO Finland
Removal of extra-, para- or intracorporeal VAD
80.5
7.4
8
*
120
NOMESCO Finland
NA
80.5
7.4
8
*
3A149
NOMESCO Finland
NA
80.5
7.4
8
*
72
HP
Catheter ablation of arrhythmia
6.5
7.4
18
28
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.3
7.4
64
283
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
7.4
141
847
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.2
7.3
26
63
Z50.0
ICD-10 Finland
Cardiac rehabilitation
4.2
7.3
26
63
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
7.3
301
2199
FJA00
NOMESCO Finland
Biopsy of right ventricle
+∞
7.3
7
*
FXE00
NOMESCO Finland
Use of ECLA
+∞
7.3
7
*
L04AD01
ATC
ciclosporin; systemic
3.2
7.3
36
115
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.6
7.3
51
203
Z94.0
ICD-10 Finland
Kidney transplant status
4.4
7.2
24
55
AT7
HP
Replacing the pacemaker VVI (R) S
30.2
7.2
9
*
L28
ICPC
Limited function/disability (L)
1.6
7.1
187
1233
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.1
7.1
75
366
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.0
7.1
90
473
R94.3
ICD-10 Finland
Abnormal results of cardiovascular function studies
5.7
7.1
19
34
J01DB01
ATC
cefalexin; oral
1.4
7.1
974
8811
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.2
7.1
70
332
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.0
7.0
83
422
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
7.0
286
2084
I20.09
ICD-10 Finland
Unstable angina
2.1
6.9
78
391
J01MA12
ATC
levofloxacin; systemic
1.5
6.9
219
1510
M10
ICD-10 Finland
Gout
2.2
6.8
63
289
FM2CE
NOMESCO Finland
NA
6.7
6.8
16
24
XF602
NOMESCO Finland
Bloodpressure monitoring
4.2
6.8
24
58
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
9.4
6.8
13
14
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
40.3
6.8
8
*
FPE36
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with ventricular electrodes
40.3
6.8
8
*
I49.2
ICD-10 Finland
Junctional premature depolarization
16.8
6.7
10
6
AT4
HP
Physiological pacemaker replacement DDD (R)
16.8
6.7
10
6
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.7
349
2665
N18.0
ICD-10 Finland
End-stage renal disease
4.1
6.7
24
59
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
22.6
6.7
9
*
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
6.5
6.6
16
25
B03XA02
ATC
darbepoetin alfa; parenteral
3.5
6.6
29
85
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.0
6.6
35
118
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
3.6
6.6
28
80
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.0
6.6
84
441
I48.4
ICD-10 Finland
Atypical atrial flutter
8.7
6.6
13
15
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.6
367
2837
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
4.4
6.5
22
51
I45.6
ICD-10 Finland
Pre-excitation syndrome
10.1
6.5
12
12
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.5
251
1808
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.9
6.4
94
518
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
6.4
117
693
R50.9
ICD-10 Finland
Fever, unspecified
1.6
6.4
169
1112
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
3.3
6.4
29
88
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.0
6.4
34
116
A12AA04
ATC
calcium carbonate; oral
3.4
6.3
28
83
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.3
237
1694
C09CA01
ATC
losartan; oral
1.4
6.3
277
2046
TFP59
NOMESCO Finland
Ablation treatment of other ventricular tachycardia
18.1
6.3
9
5
T86.2
ICD-10 Finland
Heart transplant failure and rejection
+∞
6.3
6
*
AT8
HP
Physiological pacemaker replacement DDD (R) S
+∞
6.3
6
*
I42.7
ICD-10 Finland
Cardiomyopathy due to drugs and other external agents
+∞
6.3
6
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.9
6.2
36
127
C01BA01
ATC
quinidine; oral
4.8
6.2
19
40
E85.89
ICD-10 Finland
Other amyloidosis
26.8
6.2
8
*
WX882
NOMESCO Finland
High dependency care
2.5
6.2
44
177
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.4
6.2
48
204
N17.8
ICD-10 Finland
Other acute renal failure
4.3
6.1
21
50
WVA40
NOMESCO Finland
Initiation and monitoring of intravenous hydration
4.1
6.1
22
55
C02AC05
ATC
moxonidine; oral
2.2
6.1
60
283
4254A
ICD-9 Finland
Cardiomyopathy, Other primary cardiomyopathies
12.6
6.1
10
8
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.7
6.1
126
778
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
6.7
6.0
14
21
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.2
6.0
60
286
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPERTROCARDMYOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTROCARDMYOP | 2.278 [2.01, 2.58] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 1042 out of 3023 females with I9_HYPERTROCARDMYOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTROCARDMYOP | 2.279 [2.02, 2.57] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 1466 out of 4413 males with I9_HYPERTROCARDMYOP died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPERTROCARDMYOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.198% | 0.512% |
| 5 | 1.152% | 3.223% |
| 10 | 3.025% | 7.759% |
| 15 | 5.527% | 14.259% |
| 20 | 10.037% | 22.336% |
Relationships between endpoints
↥Index endpoint: I9_HYPERTROCARDMYOP – Hypertrophic cardiomyopathy
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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