hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
685 |
4. Check minimum number of eventsNone |
685 |
5. Include endpointsNone |
685 |
6. Filter based on genotype QC (FinnGen only) |
685 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- I42
- Name in latin
- Cardiomyopathia hypertrophica obstructiva
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy, Hypertrophic obstructive
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases, wide
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5095 | 2157 | 2870 |
| Only index persons | 3542 | 1521 | 2021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.08 |
| Only index persons | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 59.89 | 63.64 | 56.99 |
| Only index persons | 58.98 | 62.46 | 56.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 685 | 285 | 400 |
| Unadjusted period prevalence (%) | 0.14 | 0.10 | 0.18 |
| Median age at first event (years) | 58.49 | 58.94 | 58.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 634
- Matched controls
- 6339
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
323.0
284
*
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
323.0
581
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
215.1
319.6
310
28
207
Kela drug reimbursment
Chronic arrhythmias
709.4
274.3
252
6
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
264.7
235
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
854.2
243.3
224
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
27.7
242.7
363
292
I50.9
ICD-10 Finland
Heart failure, unspecified
194.1
227.3
226
18
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
810.5
189.3
177
*
XF404
NOMESCO Finland
Ambulatory ECG
44.0
177.6
221
76
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
2092.7
168.6
156
*
B01AA03
ATC
warfarin; systemic
18.4
168.2
284
267
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
526.5
168.0
160
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
64.5
163.7
188
41
C07AB07
ATC
bisoprolol; oral
11.4
162.5
494
1496
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
158.1
145
*
TFP20
NOMESCO Finland
Cardiodefibrillation
400.0
157.4
152
5
C03CA01
ATC
furosemide; systemic
10.7
148.1
360
695
I50.0
ICD-10 Finland
Congestive heart failure
884.3
147.3
139
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
876.2
146.2
138
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
12.8
143.0
290
390
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
10.1
131.9
318
576
C03DA01
ATC
spironolactone; oral
17.2
130.1
220
190
I50.1
ICD-10 Finland
Left ventricular failure
+∞
124.1
115
*
C01BD01
ATC
amiodarone; systemic
719.6
123.7
118
*
I47.2
ICD-10 Finland
Ventricular tachycardia
1268.1
112.1
106
*
C01AA05
ATC
digoxin; systemic
45.9
97.9
120
32
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
86.5
81
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
244.8
84.6
85
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
17.2
77.1
126
90
XF402
NOMESCO Finland
ECG with work load test
8.9
76.8
180
270
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
71.2
67
*
AN1
HP
Coronary angiography
8.1
69.4
173
282
B01AF02
ATC
apixaban; oral
20.6
62.1
94
53
4251A
ICD-9 Finland
Cardiomyopathy, Hypertrophic obstructive cardiomyopathy
+∞
61.5
58
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
61.5
58
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
332.9
60.4
60
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
171.4
60.1
62
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
57.2
54
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.8
56.8
184
417
I49.5
ICD-10 Finland
Sick sinus syndrome
307.7
56.2
56
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
307.7
56.2
56
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
108.2
54.8
59
6
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
574.7
54.4
53
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.7
54.2
226
673
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
53.1
363
1677
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
18.7
52.5
82
50
GD1LA
NOMESCO Finland
GD
276.7
50.9
51
*
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
+∞
50.7
48
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.7
49.2
112
152
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
10.0
46.9
98
114
TFP34
NOMESCO Finland
Electrophysiological investigation
+∞
46.4
44
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
46.4
44
*
K78
ICPC
Atrial fibrillation/flutter
20.8
46.0
69
37
C09AA05
ATC
ramipril; oral
3.9
45.4
236
838
XF640
NOMESCO Finland
NA
29.2
45.2
61
23
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
17.1
44.8
72
47
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
+∞
44.3
42
*
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
+∞
44.3
42
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.5
42.7
177
506
Z2221
NOMESCO Finland
Medical doctor
3.5
42.3
257
1026
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
42.2
40
*
C07AA07
ATC
sotalol; systemic
18.9
42.1
65
38
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
+∞
40.0
38
*
Z94.1
ICD-10 Finland
Heart transplant status
400.4
38.5
38
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
89.9
38.3
42
5
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
30.4
36.1
48
17
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
8.1
35.9
84
117
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
35.8
34
*
C09DX04
ATC
valsartan and sacubitril; oral
+∞
35.8
34
*
C07AB02
ATC
metoprolol; systemic
3.6
34.8
187
656
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
355.3
34.3
34
*
81
HP
Angiography of the heart and coronary arteries
7.2
34.2
87
137
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
+∞
33.6
32
*
C01BA03
ATC
disopyramide; systemic
344.1
33.2
33
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
37.4
33.2
42
12
I48.2
ICD-10 Finland
Chronic atrial fibrillation
+∞
32.6
31
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
18.0
32.0
50
30
ZXE00
NOMESCO Finland
One hour or less
2.8
31.9
306
1590
WX892
NOMESCO Finland
Monitored bed care
5.7
31.6
96
191
C08DA01
ATC
verapamil; systemic
12.7
31.0
56
48
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.3
30.7
192
747
I44.1
ICD-10 Finland
Atrioventricular block, second degree
316.7
30.1
30
*
R06.0
ICD-10 Finland
Dyspnoea
3.2
30.0
195
777
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
29.5
297
1562
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
29.4
28
*
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
29.4
28
*
AS4
HP
Physiological pacemaker insertion DDD (R)
+∞
28.3
27
*
AS8
HP
Physiological arrhythmia pacemaker insertionDDD (R) S
+∞
28.3
27
*
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
+∞
28.3
27
*
I50
ICD-10 Finland
Heart failure
28.8
28.3
38
14
M04AA01
ATC
allopurinol; systemic
3.8
28.2
133
412
XFE00
NOMESCO Finland
Epicardial ultrasonography
16.6
28.1
45
29
I48.1
ICD-10 Finland
Persistent atrial fibrillation
293.8
28.0
28
*
A12BA01
ATC
potassium chloride; oral
8.4
28.0
63
82
I34.1
ICD-10 Finland
Mitral (valve) prolapse
151.7
27.9
29
*
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
+∞
27.3
26
*
71
HP
Electrophysiological Special Examination
282.4
26.9
27
*
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
146.2
26.8
28
*
Z3231
NOMESCO Finland
Registered nurse
2.8
26.8
229
1078
R55
ICD-10 Finland
Syncope and collapse
4.2
26.6
111
307
L04AA06
ATC
mycophenolic acid; systemic
16.6
26.3
42
27
I42
ICD-10 Finland
Cardiomyopathy
+∞
26.2
25
*
TFP35
NOMESCO Finland
Electroanatomical mapping
+∞
26.2
25
*
42500
ICD-8 Finland
Cardiomyopathy, Stenosis subaortae hypertrophicans
+∞
26.2
25
*
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
26.2
25
*
WX872
NOMESCO Finland
Intensive care
7.4
26.1
64
95
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
26.0
277
1475
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
5.4
25.2
79
162
127
Kela drug reimbursment
Transplant complication
18.0
25.2
39
23
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
+∞
25.2
24
*
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
135.3
24.8
26
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.2
24.5
68
120
R4110
NOMESCO Finland
Physiotherapy
2.7
24.2
213
1007
AQ1
HP
Conventional electrophysiological examination
+∞
24.1
23
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
23.8
203
943
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
19.4
23.3
35
19
C01BC04
ATC
flecainide; systemic
86.7
22.8
25
*
WX740
NOMESCO Finland
Nitrogen oxide therapy
238.2
22.8
23
*
FN2EG
NOMESCO Finland
Catheter-based alcohol septal ablation
+∞
22.0
21
*
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
+∞
22.0
21
*
K84
ICPC
Heart disease other
12.5
21.8
39
33
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
227.5
21.7
22
*
TK800
NOMESCO Finland
Hemodialysis
13.5
21.4
37
29
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
+∞
20.9
20
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
+∞
20.9
20
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
216.8
20.7
21
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
20.7
66
138
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
49.7
20.3
24
5
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
28.1
20.2
27
10
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
+∞
19.9
19
*
AP4
HP
Myocardial biopsy
+∞
19.9
19
*
ZXD05
NOMESCO Finland
Urgent procedure
2.4
19.8
210
1078
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
19.7
119
438
I45.9
ICD-10 Finland
Conduction disorder, unspecified
108.4
19.7
21
*
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
9.2
19.2
40
46
C01DA14
ATC
isosorbide mononitrate; oral
3.1
19.1
116
428
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
19.1
195
980
FLE10
NOMESCO Finland
Myotomy or myectomy of left ventricle for outlet obstruction
+∞
18.8
18
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
18.7
176
843
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
18.7
151
667
AP2
HP
Catheterization of the right side of the heart
195.5
18.6
19
*
TK810
NOMESCO Finland
Hemofiltration
31.1
18.5
24
8
AP1
HP
Catheterization of the left side of the heart
12.9
18.3
32
26
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.7
18.3
138
585
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
+∞
17.8
17
*
FPJ22
NOMESCO Finland
Revision of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
17.8
17
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
17.7
128
525
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
184.9
17.6
18
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
10.2
17.3
34
35
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
17.0
115
452
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.7
16.9
78
233
7AX01
NOMESCO Finland
NA
+∞
16.7
16
*
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
+∞
16.7
16
*
42509
ICD-8 Finland
Cardiomyopathy, Unspecified
+∞
16.7
16
*
M10.9
ICD-10 Finland
Gout, unspecified
4.3
16.7
64
162
Z3226
NOMESCO Finland
Physiotherapist
2.5
16.5
143
651
3A064
NOMESCO Finland
NA
+∞
15.7
15
*
AP3
HP
Catheterization of the right and left side of the heart
+∞
15.7
15
*
C07AG02
ATC
carvedilol; oral
4.0
15.7
64
172
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
87.3
15.6
17
*
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
87.3
15.6
17
*
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
39.1
15.5
19
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
15.0
139
655
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
+∞
14.6
14
*
FPE40
NOMESCO Finland
Replacement of transvenous cardiac pacemaker electrode
+∞
14.6
14
*
ATX
HP
Other pacemaker replacement or related action, such as cord removal or replacement
+∞
14.6
14
*
C01BA01
ATC
quinidine; oral
+∞
14.6
14
*
R00.1
ICD-10 Finland
Bradycardia, unspecified
10.4
14.6
28
28
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
14.5
76
251
ZXE40
NOMESCO Finland
More than seven and less than nine hours
8.9
14.4
30
35
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.4
14.2
141
684
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.1
14.2
45
94
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
14.1
79
273
3AC01
NOMESCO Finland
NA
30.8
13.9
18
6
1CX08
NOMESCO Finland
NA
54.6
13.9
16
*
B01AE07
ATC
dabigatran etexilate; oral
9.4
13.8
28
31
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
13.8
84
308
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.5
13.7
40
76
Z2446
NOMESCO Finland
Social worker
3.6
13.6
63
189
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
+∞
13.6
13
*
74
HP
Initial installation of the atrial pacemaker
+∞
13.6
13
*
72
HP
Catheter ablation of arrhythmia
+∞
13.6
13
*
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
+∞
13.6
13
*
C10AA01
ATC
simvastatin; oral
1.9
13.5
300
2028
G04BE03
ATC
sildenafil; oral
7.3
13.5
32
46
R53
ICD-10 Finland
Malaise and fatigue
2.4
13.2
126
599
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.4
13.1
119
551
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
5.7
13.0
37
68
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.8
12.9
27
32
I20.00
ICD-10 Finland
Unstable angina
6.1
12.7
34
58
K77
ICPC
Heart failure
15.8
12.7
20
13
I44.0
ICD-10 Finland
Atrioventricular block, first degree
71.3
12.6
14
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
12.6
68
230
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
+∞
12.5
12
*
K83
ICPC
Heart valve disease NOS
+∞
12.5
12
*
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
12.5
12
*
ZX120
NOMESCO Finland
Intravenous
3.0
12.5
75
271
ZX108
NOMESCO Finland
Inhalation
14.7
12.3
20
14
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
12.3
58
177
H02AB06
ATC
prednisolone; systemic
1.9
12.2
284
1929
C08DB01
ATC
diltiazem; oral
4.2
12.0
45
112
B01AB05
ATC
enoxaparin; parenteral
2.0
11.8
190
1128
205
Kela drug reimbursment
Chronic hypertension
2.0
11.7
184
1083
C02DE01
ATC
NA
23.4
11.6
16
7
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.0
11.5
46
122
AK1
HP
HTX (heart transplant)
+∞
11.5
11
*
XFP02
NOMESCO Finland
NA
+∞
11.5
11
*
I41.8*D86.8
ICD-10 Finland
Sarcoid myocarditis
+∞
11.5
11
*
73
HP
Initial pacemaker installation
+∞
11.5
11
*
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
+∞
11.5
11
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
11.2
179
1056
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.6
11.2
51
152
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
11.2
220
1400
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
11.1
93
409
I25.2
ICD-10 Finland
Old myocardial infarction
3.7
11.1
49
142
C03AA03
ATC
hydrochlorothiazide; oral
2.8
11.0
71
270
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
44.1
11.0
13
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
44.1
11.0
13
*
Z50.0
ICD-10 Finland
Cardiac rehabilitation
10.8
10.8
20
19
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
8.7
10.6
22
26
K80
ICPC
Cardiac arrhythmia NOS
4.0
10.6
42
111
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.8
10.5
69
266
XF409
NOMESCO Finland
Other special ECG
111.8
10.4
11
*
FPG42
NOMESCO Finland
Replacement of electrode(s) in transvenous cardioverter-defibrillator
+∞
10.4
10
*
FPJ00
NOMESCO Finland
Revision of pacemaker pulse generator or electrode
+∞
10.4
10
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
+∞
10.4
10
*
FXL00
NOMESCO Finland
Insertion and use of extra-, para- or intracorporeal VAD
+∞
10.4
10
*
4254A
ICD-9 Finland
Cardiomyopathy, Other primary cardiomyopathies
+∞
10.4
10
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
10.4
10
*
APS
HP
Ventricular septal alcohol ablation (septic vascular embolization)
+∞
10.4
10
*
742
NOMESCO Finland
NA
+∞
10.4
10
*
R50.9
ICD-10 Finland
Fever, unspecified
2.4
10.4
92
419
B01AF01
ATC
rivaroxaban; oral
2.8
10.3
68
263
R04.0
ICD-10 Finland
Epistaxis
3.5
10.3
48
146
H03BB01
ATC
carbimazole; oral
5.6
10.2
29
54
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
10.2
59
209
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
10.2
39
100
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.7
10.1
68
266
C09AA04
ATC
perindopril; oral
3.8
10.1
42
116
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
11.5
10.1
18
16
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.4
10.1
23
32
C08CA02
ATC
felodipine; oral
2.7
10.0
72
291
R02
ICPC
Shortness of breath/dyspnoea
2.6
10.0
75
311
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.4
9.9
48
150
N19
ICD-10 Finland
Unspecified kidney failure
5.6
9.9
28
52
WX002
NOMESCO Finland
Sedation and analgesia
2.0
9.8
132
724
FM1LE
NOMESCO Finland
Combined ultrasound and EKG examination of heart with tolerance test
26.5
9.8
13
5
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
7.6
9.8
22
30
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
9.7
351
2669
C10AA05
ATC
atorvastatin; oral
1.8
9.7
238
1611
5AB14
NOMESCO Finland
NA
55.9
9.7
11
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
11.6
9.6
17
15
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
9.3
9.6
19
21
J01FF01
ATC
clindamycin; systemic
1.9
9.5
163
978
AA1AD
NOMESCO Finland
CT of head and brain
2.0
9.5
143
818
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
101.5
9.4
10
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.4
255
1775
XF406
NOMESCO Finland
High resolution ECG
+∞
9.4
9
*
42508
ICD-8 Finland
Cardiomyopathy, Alia definita
+∞
9.4
9
*
4259X
ICD-9 Finland
Cardiomyopathy, Secondary cardiomyopathy, unspecified
+∞
9.4
9
*
TK830
NOMESCO Finland
Ultrafiltration
+∞
9.4
9
*
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
+∞
9.4
9
*
ASB
HP
Insertion of a biventricular physiological pacemaker DDD (R)
+∞
9.4
9
*
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
+∞
9.4
9
*
C01BB02
ATC
mexiletine; systemic
+∞
9.4
9
*
FPG04
NOMESCO Finland
Insertion of internal defibrillator, atrial and chamber electrode
+∞
9.4
9
*
G47.3
ICD-10 Finland
Sleep apnoea
2.0
9.4
141
808
I20.90
ICD-10 Finland
Angina pectoris, unspecified
4.9
9.3
29
61
N18.0
ICD-10 Finland
End-stage renal disease
13.9
9.2
15
11
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
13.9
9.2
15
11
C07AB03
ATC
atenolol; systemic
3.3
9.2
46
148
J01CA04
ATC
amoxicillin; systemic
1.8
9.2
467
3894
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.5
9.1
19
23
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
9.0
73
316
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.0
9.0
51
179
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
24.4
8.9
12
5
Z82.7
ICD-10 Finland
Family history of congenital malformations, deformations and chromosomal abnormalities
24.4
8.9
12
5
L04AD01
ATC
ciclosporin; systemic
6.5
8.8
22
35
E87.5
ICD-10 Finland
Hyperkalaemia
8.8
8.8
18
21
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.9
8.6
27
57
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.2
8.6
94
469
N18.8
ICD-10 Finland
Other chronic renal failure
5.3
8.6
25
49
M10
ICD-10 Finland
Gout
3.6
8.5
37
107
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
91.2
8.4
9
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
8.0
8.4
18
23
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
8.4
45
153
A11CC03
ATC
alfacalcidol; systemic
6.3
8.4
21
34
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
+∞
8.3
8
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
+∞
8.3
8
*
63
HP
Cardiac muscle biopsy
+∞
8.3
8
*
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
+∞
8.3
8
*
FPH20
NOMESCO Finland
Removal of epicardial pacemaker or cardioverter-defibrillator
+∞
8.3
8
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
+∞
8.3
8
*
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
8.3
8
*
C09AA01
ATC
captopril; oral
8.7
8.3
17
20
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
8.3
90
451
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.9
8.3
33
89
J01DB01
ATC
cefalexin; oral
1.7
8.3
478
4062
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
3.6
8.2
36
105
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.6
8.2
36
105
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.1
8.2
30
75
I20.99
ICD-10 Finland
Angina pectoris, unspecified
3.0
8.1
46
160
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
8.3
8.1
17
21
C09AA02
ATC
enalapril; systemic
1.9
8.1
126
730
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
22.3
8.0
11
5
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.3
8.0
39
124
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.9
58
240
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
7.8
66
293
I20.09
ICD-10 Finland
Unstable angina
3.1
7.8
41
138
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
15.3
7.7
12
8
E05.89
ICD-10 Finland
Other thyrotoxicosis
45.5
7.7
9
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.4
7.7
35
106
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
7.6
152
953
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.9
7.6
44
158
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
81.0
7.4
8
*
FM1JR
NOMESCO Finland
Heart, extensive metabolic PET with CT
81.0
7.4
8
*
62
HP
Catheterization and pressure measurement of the right side of the heart
81.0
7.4
8
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
81.0
7.4
8
*
XF600
NOMESCO Finland
Bloodpressure measurement
3.0
7.4
42
147
A02BC02
ATC
pantoprazole; systemic
1.6
7.4
365
2924
C10AA03
ATC
pravastatin; oral
2.7
7.3
50
197
A46
ICD-10 Finland
Erysipelas
2.1
7.3
85
436
I47.0
ICD-10 Finland
Re-entry ventricular arrhythmia
+∞
7.3
7
*
FPB22
NOMESCO Finland
Transvenous radiofrequency ablation of aberrant pathway or focus of heart
+∞
7.3
7
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
7.3
7
*
I48.4
ICD-10 Finland
Atypical atrial flutter
+∞
7.3
7
*
4271A
ICD-9 Finland
Cardiac dysrhythmias, Paroxysmal ventricular tachycardia
+∞
7.3
7
*
FKC96
NOMESCO Finland
Other repair of mitral valve for insufficiency
+∞
7.3
7
*
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
+∞
7.3
7
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
7.3
7
*
I42.5
ICD-10 Finland
Other restrictive cardiomyopathy
+∞
7.3
7
*
I46.9
ICD-10 Finland
Cardiac arrest, unspecified
+∞
7.3
7
*
FPJ21
NOMESCO Finland
Revision of cardioverter-defibrillator with ventricular electrode
+∞
7.3
7
*
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
+∞
7.3
7
*
I42.4
ICD-10 Finland
Endocardial fibroelastosis
+∞
7.3
7
*
ZX197
NOMESCO Finland
NA
+∞
7.3
7
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
7.3
7
*
I45.6
ICD-10 Finland
Pre-excitation syndrome
+∞
7.3
7
*
Z95.9
ICD-10 Finland
Presence of cardiac and vascular implant and graft, unspecified
+∞
7.3
7
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
7.3
54
225
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.0
7.2
27
69
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
16.0
7.2
11
7
Y0399
ICD-8 Finland
Investigation of circulatory system
7.4
7.2
16
22
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.0
7.2
41
144
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.7
7.2
29
80
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
8.1
7.1
15
19
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
5.4
7.1
20
38
A12AA04
ATC
calcium carbonate; oral
8.9
7.1
14
16
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.6
7.1
49
196
UJF32
NOMESCO Finland
Coloscopy
1.7
7.0
150
956
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.9
82
426
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
5.4
6.8
19
36
61
HP
Catheterization and pressure measurement of the left side of the heart
5.8
6.8
18
32
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.1
6.8
35
117
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
6.8
29
84
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
40.5
6.8
8
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
16.9
6.8
10
6
R11
ICD-10 Finland
Nausea and vomiting
2.6
6.7
48
197
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
6.7
276
2099
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
22.8
6.7
9
*
B01AF03
ATC
edoxaban; oral
22.8
6.7
9
*
Z31.5
ICD-10 Finland
Genetic counselling
3.3
6.7
31
96
K04
ICPC
Palpitations/awareness of heart
4.3
6.7
23
55
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
6.7
164
1089
FL1AC
NOMESCO Finland
Left cardioangiography
7.9
6.6
14
18
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.4
6.6
22
51
Z94.0
ICD-10 Finland
Kidney transplant status
10.2
6.6
12
12
R2110
NOMESCO Finland
Giving the first information
2.8
6.5
40
150
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
4.6
6.5
21
47
2BD01
NOMESCO Finland
NA
70.5
6.4
7
*
WX902
NOMESCO Finland
External defibrillation of heart
70.5
6.4
7
*
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
8.3
6.4
13
16
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.6
6.3
44
175
I49.8
ICD-10 Finland
Other specified cardiac arrhythmias
6.0
6.3
16
27
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.6
6.3
42
166
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.9
6.3
36
128
4289X
ICD-9 Finland
Heart failure, unspecified
+∞
6.3
6
*
XF645
NOMESCO Finland
Heart ultrasound examination with load test
+∞
6.3
6
*
TFP52
NOMESCO Finland
Ablation treatment of ventricular tachycardia due to structural heart defect
+∞
6.3
6
*
FPE24
NOMESCO Finland
Implantation of biventricular cardiac pacemaker, ventricular electrodes, CRT-P (VVIR)
+∞
6.3
6
*
342
Kela drug reimbursment
Dronedarone
+∞
6.3
6
*
FJA00
NOMESCO Finland
Biopsy of right ventricle
+∞
6.3
6
*
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
+∞
6.3
6
*
I41.8
ICD-10 Finland
Myocarditis in other diseases classified elsewhere
+∞
6.3
6
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
+∞
6.3
6
*
I51.7
ICD-10 Finland
Cardiomegaly
+∞
6.3
6
*
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
27.0
6.2
8
*
J81
ICD-10 Finland
Pulmonary oedema
27.0
6.2
8
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.4
6.2
28
85
R03BB04
ATC
tiotropium bromide; inhalant
2.1
6.2
65
321
C10AX09
ATC
ezetimibe; oral
2.2
6.1
64
313
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.7
6.1
10
8
D86.0
ICD-10 Finland
Sarcoidosis of lung
6.8
6.1
14
21
C02EA01
ATC
NA
10.2
6.0
11
11
R23.3
ICD-10 Finland
Spontaneous ecchymoses
5.6
6.0
16
29
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOHYP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOHYP | 2.125 [1.83, 2.47] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 446 out of 1326 females with I9_CARDMYOHYP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOHYP | 2.113 [1.81, 2.47] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 1732 males with I9_CARDMYOHYP died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOHYP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.382% |
| 5 | 1.246% | 2.525% |
| 10 | 3.069% | 6.487% |
| 15 | 5.663% | 11.863% |
| 20 | 9.796% | 20.165% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 23
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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