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Localized skin eruption due to drugs and medicaments

EFO Endpoint Browser PheWeb

LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L27.1#

1 out of 7 registries used, show all original rules.

429

4. Check minimum number of events

None

429

5. Include endpoints

None

429

6. Filter based on genotype QC (FinnGen only)

412

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2626 1498 1115
Only index persons 2347 1368 979
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 51.43 54.02 47.91
Only index persons 52.21 54.10 49.55

-FinnGen-

Key figures

All Female Male
Number of individuals 412 260 152
Unadjusted period prevalence (%) 0.08 0.09 0.07
Median age at first event (years) 56.23 53.02 61.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
429
Matched controls
4290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L27.1
ICD-10 Finland
Localized skin eruption due to drugs and medicaments
4503599627370496.0
307.7
428
*
H02AB06
ATC
prednisolone; systemic
4.6
48.3
305
1492
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.4
43.5
103
239
XQ800
NOMESCO Finland
Prick test
5.7
38.8
82
171
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.3
27.2
137
534
D07AC01
ATC
betamethasone; topical
2.8
23.3
206
1077
XQ802
NOMESCO Finland
Epicutan test
5.9
23.1
44
82
R06AE07
ATC
cetirizine; oral
2.7
22.3
243
1401
E0000UV, ,
ATC
2.6
20.9
227
1294
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.9
20.7
68
198
R06AX27
ATC
desloratadine; oral
2.6
19.3
167
847
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
15.8
19.2
31
21
XQ820
NOMESCO Finland
Exposure to medicinal substance
46.2
18.4
22
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
18.2
228
1363
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
16.2
147
751
J01MA02
ATC
ciprofloxacin; systemic
2.3
15.7
195
1140
N02AX02
ATC
tramadol; systemic, rectal
2.3
15.5
214
1306
J01FF01
ATC
clindamycin; systemic
2.4
15.1
145
757
T78.4
ICD-10 Finland
Allergy, unspecified
4.5
14.6
37
88
A02BC02
ATC
pantoprazole; systemic
2.3
13.4
309
2266
L50.0
ICD-10 Finland
Allergic urticaria
5.6
13.4
26
49
XQ801
NOMESCO Finland
Intracutantest
18.0
12.6
19
11
J01AA02
ATC
doxycycline; systemic
2.5
12.2
351
2763
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.0
11.9
59
220
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
6.1
11.9
21
36
UJF32
NOMESCO Finland
Coloscopy
2.2
11.9
129
699
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
11.8
120
632
R06AE09
ATC
levocetirizine; oral
2.5
11.6
84
381
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
11.3
149
868
N03AX16
ATC
[U] pregabalin
2.2
11.3
118
628
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
11.2
103
520
H02AB02
ATC
dexamethasone; systemic
2.7
11.1
65
265
A02BC05
ATC
esomeprazole; systemic
2.0
11.1
193
1242
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
11.0
61
242
J02AC01
ATC
fluconazole; systemic
2.0
10.9
192
1237
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.2
10.9
45
151
H02AB07
ATC
prednisone; oral
2.5
10.9
75
332
R50.9
ICD-10 Finland
Fever, unspecified
2.4
10.7
83
388
J01DB01
ATC
cefalexin; oral
2.6
10.4
371
3067
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
10.4
100
513
D07AD01
ATC
clobetasol; topical
2.3
10.4
86
414
M13.9
ICD-10 Finland
Arthritis, unspecified
3.0
10.3
47
167
J46
ICD-10 Finland
Status asthmaticus
5.2
10.1
21
42
A04AA01
ATC
ondansetron; systemic, rectal
3.0
10.1
48
175
J01MA12
ATC
levofloxacin; systemic
2.3
9.9
88
436
S29
ICPC
Skin symptom/complaint other
2.2
9.6
98
513
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.1
9.6
103
550
L50.9
ICD-10 Finland
Urticaria, unspecified
3.7
9.5
31
89
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
9.3
68
309
UDC00
NOMESCO Finland
Ear microscopy
2.8
9.1
48
185
E000001, ,
ATC
2.1
9.1
100
538
S18
ICPC
Laceration/cut
1.9
9.0
206
1422
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
9.0
106
586
D07AC13
ATC
mometasone; topical
2.0
9.0
135
814
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
8.9
60
262
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
8.8
151
949
L17
ICPC
Foot/toe symptom/complaint
1.9
8.8
137
834
A02BC03
ATC
lansoprazole; oral
1.9
8.7
136
830
J01FA09
ATC
clarithromycin; systemic
1.9
8.6
151
956
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
8.6
66
306
R03BA05
ATC
fluticasone; inhalant
2.1
8.6
95
512
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.3
8.5
71
342
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
8.4
115
668
ZX120
NOMESCO Finland
Intravenous
2.6
8.2
51
214
R02
ICPC
Shortness of breath/dyspnoea
2.3
8.1
66
313
R03AC02
ATC
salbutamol; inhalant
1.8
8.0
252
1893
H02AB04
ATC
methylprednisolone; systemic
2.2
8.0
72
357
B01AB05
ATC
enoxaparin; parenteral
1.9
8.0
145
925
L04AX03
ATC
methotrexate; systemic
2.4
7.9
55
243
J05AB01
ATC
aciclovir; systemic
1.9
7.8
112
660
XG410
NOMESCO Finland
Flow-volume spirometry
3.6
7.8
26
76
R03BA02
ATC
budesonide; inhalant
2.0
7.8
91
499
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
7.8
91
499
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
7.8
52
226
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
7.8
121
733
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.8
118
709
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
7.8
59
272
C01CA24
ATC
epinephrine; parenteral
2.7
7.7
42
165
N05BA04
ATC
oxazepam; oral
1.9
7.7
125
768
WZC30
NOMESCO Finland
Teaching
2.1
7.5
78
408
R03DC03
ATC
montelukast; oral
2.1
7.5
84
452
J01DA01
ATC
[U] cefalexin
1.8
7.4
271
2109
J01FA06
ATC
roxithromycin; oral
1.8
7.3
175
1205
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
7.3
117
713
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
7.3
132
836
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.1
7.2
20
51
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
7.2
117
716
D07AB08
ATC
desonide; topical
2.3
7.2
58
274
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
7.2
168
1148
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.6
7.2
41
165
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
6.2
7.1
18
30
L08
ICPC
Shoulder symptom/complaint
1.9
7.0
100
587
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
6.9
183
1291
N05CF01
ATC
zopiclone; oral
1.8
6.9
141
926
N48.1
ICD-10 Finland
Balanoposthitis
5.8
6.8
18
32
R01AD08
ATC
fluticasone; nasal
1.8
6.8
134
869
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.0
6.8
19
49
S09
ICPC
Infected finger/toe
3.8
6.7
20
54
SPAT1263
SPAT
Sampling
1.7
6.7
184
1310
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
6.7
155
1053
M03BX02
ATC
tizanidine; oral
1.7
6.6
268
2113
M79.6
ICD-10 Finland
Pain in limb
1.7
6.6
184
1312
M54.5
ICD-10 Finland
Low back pain
1.7
6.6
160
1098
UKC02
NOMESCO Finland
Cystoscopy
2.1
6.6
67
347
R00.2
ICD-10 Finland
Palpitations
2.5
6.6
43
185
D02AX
ATC
Other emollients and protectives
3.8
6.5
20
55
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
2.9
6.5
31
113
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.9
6.5
30
108
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
6.4
233
1778
A46
ICD-10 Finland
Erysipelas
2.1
6.4
63
322
TQW80
NOMESCO Finland
Local dermatologic skincare
4.2
6.4
17
42
R06AX13
ATC
loratadine; oral
2.0
6.4
75
410
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
6.4
49
227
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.4
96
572
R51.80
ICD-10 Finland
Headache
1.9
6.3
82
464
J01FA10
ATC
azithromycin; systemic
1.7
6.3
259
2038
R01AD09
ATC
mometasone; nasal
1.7
6.3
202
1492
L04AB01
ATC
etanercept; parenteral
7.2
6.3
14
20
C09CA06
ATC
candesartan; oral
1.8
6.2
101
615
L03AA13
ATC
pegfilgrastim; parenteral
3.0
6.2
28
99
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.2
63
327
R03AK07
ATC
formoterol and budesonide; inhalant
1.9
6.2
94
561
H66.9
ICD-10 Finland
Otitis media, unspecified
2.6
6.1
37
153
R01BA52
ATC
pseudoephedrine, combinations; oral
1.7
6.1
130
857
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.1
84
485
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.1
102
627
ZXE00
NOMESCO Finland
One hour or less
1.7
6.1
169
1199
SPAT1301
SPAT
No procedures
1.7
6.0
136
911
JN4AD
NOMESCO Finland
Body CT examination
2.3
6.0
46
212
N02BE01
ATC
paracetamol; systemic, rectal
2.2
6.0
382
3387
N03AX12
ATC
[U] gabapentin; oral
1.9
6.0
79
449
C03CA01
ATC
furosemide; systemic
1.8
6.0
113
719

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
285
1664
3.12
27.60
8.8
6.6
—
—
—
0
0
287
1765
2.89
23.75
7.7
5.9
0.58
0.56
e9/l
0.47
263
1540
292
1816
2.90
23.58
7.9
5.9
1.80
1.93
e9/l
0.98
272
1631
286
1767
2.86
23.25
7.7
5.9
0.04
0.04
e9/l
0.98
263
1545
291
1823
2.85
22.87
7.8
6.2
0.21
0.19
e9/l
1.36
268
1626
279
1712
2.80
22.80
8.2
6.1
27.30
28.16
%
0.70
265
1625
266
1601
2.74
22.46
8.2
6.0
0.67
0.66
%
0.07
249
1500
271
1664
2.71
21.68
8.5
6.3
8.74
8.38
%
1.10
255
1574
269
1657
2.67
21.20
8.2
6.0
3.08
2.77
%
1.23
252
1565
251
1497
2.63
21.11
5.8
5.6
1.21
1.22
mmol/l
0.26
233
1378
310
2060
2.82
20.78
13.9
9.4
4.22
4.05
e9/l
0.64
285
1819
269
1693
2.58
19.69
7.9
5.9
57.25
57.09
%
0.08
254
1606
263
1663
2.50
18.67
7.1
6.5
1.22
1.22
mmol/l
0.02
211
1418
164
862
2.46
17.18
4.7
4.1
—
—
—
0
0
229
1398
2.37
17.05
6.8
4.8
35.57
35.86
g/l
0.34
212
1313
359
2701
3.02
16.79
12.5
7.5
79.83
78.27
u/l
0.28
341
2522
270
1830
2.28
14.93
9.0
6.2
10.67
10.75
umol/l
0.02
256
1740
237
1537
2.21
14.43
16.7
12.8
1.13
1.21
inr
1.20
86
489
103
489
2.46
13.00
1.5
1.3
788.89
465.05
titre
0.55
18
107
86
385
2.54
12.25
1.9
1.6
—
—
—
0
0
99
492
2.32
11.13
1.9
2.0
—
—
—
0
0
337
2654
2.26
10.95
6.2
4.1
13.50
11.35
mm/h
1.69
316
2438
148
872
2.06
10.79
3.6
3.6
92.43
92.80
%
0.06
140
850
176
1106
2.00
10.71
3.4
2.5
54.11
59.50
u/l
0.57
150
1027
96
478
2.30
10.71
3.0
2.5
112.29
123.07
ug/g
0.17
70
371
100
514
2.23
10.31
3.9
3.6
0.81
0.82
mmol/l
0.07
95
487
27
66
4.30
10.31
2.6
2.3
17.02
15.58
%
—
9
26
317
2469
2.09
10.13
6.3
4.2
—
—
—
0
0
163
1019
1.97
9.90
4.6
3.7
7.39
7.40
ph
0.75
47
204
95
488
2.22
9.77
2.6
2.1
2.44
2.39
g/l
0.31
89
450
68
302
2.49
9.75
5.9
4.5
1.09
0.91
%
0.26
27
116
44
156
3.03
9.71
1.4
1.2
—
—
—
0
0
161
1008
1.96
9.70
2.1
2.1
203.38
268.90
u/l
0.32
150
948
272
2031
1.93
9.51
5.7
4.5
6.55
6.65
mmol/l
0.37
262
1883
28
75
3.92
9.48
5.2
2.5
2.05
2.33
mmol/l
0.21
20
49
97
509
2.17
9.44
1.7
2.1
29.38
29.55
s
0.14
97
494
21
45
4.86
9.39
1.6
1.6
90.69
89.78
%
0.26
21
45
82
404
2.27
9.30
5.5
5.6
1.04
1.04
mmol/l
0.06
76
377
166
1063
1.92
9.26
3.4
2.8
—
—
—
0
0
122
708
2.01
9.04
1.9
1.7
446.34
8417941.29
pmol/l
0.50
100
594
209
1455
1.85
8.88
2.2
2.1
—
—
—
0
0
227
1627
1.84
8.73
14.9
9.4
0.00
0.00
e9/l
0.30
205
1340
62
279
2.43
8.61
6.3
4.7
0.19
0.13
%
0.27
21
93
173
1144
1.86
8.59
5.7
3.2
2.33
2.35
mmol/l
1.71
157
1008
300
2353
1.91
8.58
6.2
4.3
116.17
268.05
e6/l
—
6
43
65
303
2.35
8.34
2.6
2.3
0.22
0.22
g/l
0.17
60
286
208
1468
1.81
8.27
2.9
2.2
78.21
75.78
nmol/l
0.53
189
1314
96
528
2.05
8.17
2.8
2.1
12.85
13.50
umol/l
0.38
90
489
86
454
2.12
8.16
2.9
2.1
21.53
23.08
%
0.45
74
391
59
267
2.40
8.08
6.6
4.7
0.05
0.04
%
0.11
19
82
403
3582
3.06
7.72
24.3
13.3
18.34
21.74
mg/l
1.95
363
2818
64
308
2.27
7.61
1.6
1.4
—
—
—
0
0
101
580
1.97
7.57
1.8
1.7
1302.11
1199.53
nmol/l
0.50
74
435
224
1647
1.75
7.49
3.6
2.6
119.72
103.94
ug/l
0.40
205
1520
23
64
3.74
7.40
5.7
2.3
—
—
—
0
0
107
635
1.91
7.25
1.4
1.3
16.51
35.77
iu/ml
2.81
40
211
115
700
1.88
7.21
3.7
2.7
506.55
545.82
mosm/kgh2o
1.03
99
597
58
274
2.29
7.20
6.0
4.5
1.14
0.54
%
0.85
18
96
140
908
1.80
7.15
3.0
3.0
1204.35
1120.87
ng/l
0.13
118
775
119
736
1.85
7.08
3.3
2.4
5.66
5.80
e6/l
0.03
107
661
24
71
3.52
7.08
2.7
3.5
4.98
4.52
e9/l
0.33
24
71
199
1437
1.72
6.93
4.2
3.3
5.68
5.87
ph
0.31
11
115
58
280
2.24
6.84
5.0
3.8
1.21
1.23
mmol/l
1.01
50
250
233
1765
1.70
6.73
6.4
4.8
0.00
0.00
estimate
-0.00
65
364
233
1767
1.70
6.69
5.0
3.5
0.00
0.00
estimate
0.50
64
382
82
456
1.99
6.68
1.3
1.2
—
—
—
0
0
146
975
1.75
6.67
3.9
2.8
0.43
0.42
e6/l
0.02
119
711
24
74
3.38
6.66
3.5
3.9
60.63
58.34
%
0.33
24
74
158
1080
1.73
6.64
4.0
2.9
72.14
112.74
e6/l
0.25
127
816
56
271
2.23
6.56
4.3
2.6
9.72
10.35
g/l
0.57
45
251
224
1693
1.68
6.41
3.0
2.5
—
—
—
0
0
234
1790
1.68
6.39
5.0
3.6
0.00
0.01
estimate
0.50
62
356
63
323
2.11
6.39
5.9
3.6
—
—
—
0
0
125
807
1.77
6.37
1.8
1.8
0.85
1.19
mg/l
0.79
91
633
329
2763
1.82
6.36
5.6
4.0
14.77
14.64
pmol/l
0.38
306
2505
9
5
18.34
6.29
1.0
1.0
—
—
—
0
0
179
1284
1.68
6.20
4.5
3.5
21.83
35.58
ng/l
1.67
126
867
177
1271
1.67
6.08
4.6
3.4
113.92
76.54
e6/l
0.20
129
881
146
997
1.70
6.05
4.2
3.7
—
—
—
0
0
46
212
2.31
6.04
3.5
3.7
7.41
7.42
ph
—
9
20
141
955
1.71
6.02
5.4
3.9
0.00
0.00
estimate
-0.00
62
360
130
864
1.72
5.93
3.1
2.0
3.09
3.04
mg/l
0.07
110
738
14
23
6.25
5.73
2.4
2.0
40.59
37.54
%
0.30
14
23
76
434
1.91
5.70
2.0
1.6
—
—
—
0
0
140
960
1.68
5.65
3.9
2.7
—
—
—
0
0
9
7
13.10
5.60
2.1
2.0
—
—
—
0
0
133
904
1.68
5.53
3.0
2.7
5968.67
6075.39
umol/l
0.01
115
784
291
2402
1.66
5.53
4.0
3.2
48.39
45.03
u/l
0.39
269
2263
184
1359
1.62
5.51
2.2
1.9
97.55
96.43
pmol/l
0.11
100
693
73
418
1.90
5.42
1.6
1.3
—
—
—
0
0
99
626
1.76
5.33
1.4
1.3
48.94
11.23
u/ml
0.39
36
250
64
355
1.94
5.22
6.0
7.4
1.75
1.19
mmol/l
0.58
52
299
292
2432
1.63
5.16
4.4
3.6
—
—
—
0
0
129
886
1.65
5.10
10.5
6.8
—
—
—
0
0
21
71
3.06
5.06
2.7
4.4
—
—
—
0
0
49
250
2.08
5.03
5.1
8.6
—
—
—
0
0
42
202
2.20
5.00
1.2
1.2
—
—
—
0
0
10
13
7.85
4.87
1.0
1.0
—
13.74
—
0
5
37
171
2.27
4.85
5.5
9.3
—
—
—
0
0
129
901
1.62
4.72
1.5
1.3
1.69
2.17
u/ml
0.19
36
247
50
268
1.98
4.50
1.5
1.5
—
—
—
0
0
15
38
4.05
4.34
2.5
2.1
1.14
1.07
e9/l
0.11
15
32
116
804
1.61
4.33
1.8
1.5
20.96
20.87
nmol/l
0.02
103
685
26
108
2.50
4.31
1.3
1.2
—
—
—
0
0
13
31
4.29
4.04
1.7
1.4
—
—
—
0
0
53
302
1.86
3.99
1.2
1.1
—
—
—
0
0
40
207
2.03
3.97
3.1
2.2
—
—
—
0
0
366
3305
1.73
3.96
6.7
4.8
1.95
1.87
mu/l
0.41
341
3034
112
785
1.58
3.96
4.5
3.4
—
—
—
0
0
159
1204
1.51
3.95
3.7
3.2
28.70
31.83
u/l
0.85
148
1153
59
349
1.80
3.94
2.8
2.7
1.77
1.75
%
0.04
51
318
16
54
3.04
3.89
2.3
1.6
—
—
—
0
0
53
308
1.82
3.75
4.7
4.5
—
—
—
0
0
13
34
3.91
3.72
1.3
1.5
—
—
—
0
0
55
327
1.78
3.62
2.2
2.2
29.98
30.98
u/l
0.13
47
270
49
282
1.83
3.58
1.6
1.3
130.59
163.52
iu/ml
0.17
18
119
10
21
4.85
3.57
1.2
1.0
—
—
—
0
0
41
223
1.93
3.56
2.3
1.7
0.94
1.35
g/l
1.49
36
203
15
52
2.95
3.50
1.3
1.4
—
—
—
0
0
90
616
1.58
3.49
1.8
1.6
—
—
—
0
0
44
247
1.87
3.48
2.0
3.0
71.11
71.14
e9/l
0.00
31
194
146
1114
1.47
3.40
2.8
2.2
—
—
—
0
0
22
95
2.39
3.39
3.6
3.9
21.46
29.10
mg/l
0.82
16
76
22
95
2.39
3.39
3.6
3.8
222.65
121.63
mg/l
0.20
15
77
56
342
1.73
3.37
6.6
4.1
11.94
40.06
ug/l
0.60
46
278
14
48
2.98
3.33
2.1
2.0
0.41
0.92
g/l
—
9
41
14
48
2.98
3.33
2.8
3.0
—
—
—
0
0
47
274
1.80
3.30
3.2
4.2
2.14
1.83
mmol/l
0.18
39
222
137
1039
1.47
3.27
4.6
3.2
—
—
—
0
0
38
209
1.90
3.20
5.4
4.0
—
—
—
0
0
45
262
1.80
3.18
1.3
1.4
—
—
—
0
0
15
56
2.74
3.09
1.3
1.8
—
—
—
0
0
31
164
1.96
2.94
3.7
4.0
—
—
—
0
0
63
413
1.62
2.91
1.3
1.4
—
—
—
0
0
348
3171
1.52
2.87
26.0
15.9
15.19
14.69
%
0.81
348
3132
403
3809
1.96
2.87
17.7
10.1
24.94
25.66
u/l
0.50
393
3675
14
53
2.70
2.82
3.4
2.5
—
—
—
0
0
8
18
4.51
2.80
4.0
2.7
40237.50
35694.72
ug/l
—
8
18
398
3752
1.84
2.78
21.4
12.4
—
—
—
0
0
5
6
8.41
2.75
1.4
1.2
—
—
—
0
0
5
6
8.41
2.75
1.4
1.2
—
—
—
0
0
40
236
1.77
2.73
3.3
2.2
10.41
5.71
e9/l
0.31
31
199
352
3226
1.51
2.72
6.4
5.5
39.25
39.52
mmol/mol
0.22
318
3014
31
170
1.89
2.66
1.1
1.3
18.16
25.54
iu/l
0.62
26
143
22
107
2.11
2.62
1.4
2.0
8.69
11.35
mg/l
1.04
22
100
59
394
1.58
2.54
5.7
6.4
103.95
103.98
mmol/l
0.02
59
394
106
801
1.43
2.51
1.9
1.4
2.20
2.40
g/l
0.58
58
492
51
333
1.60
2.41
1.6
1.5
—
—
—
0
0
86
631
1.45
2.38
3.8
3.5
325.09
295.61
ng/l
0.04
63
466
9
28
3.26
2.32
1.7
1.8
—
—
—
0
0
75
539
1.47
2.31
3.5
2.7
4.06
2.58
e6/l
0.68
42
276
40
249
1.67
2.28
3.4
3.6
75.91
72.58
ng/l
0.13
32
225
29
165
1.81
2.25
1.1
1.1
—
—
—
0
0
5
9
5.61
2.22
10.0
3.6
49.90
47.94
%
—
5
9
22
115
1.96
2.20
6.6
3.7
—
—
—
0
0
29
167
1.79
2.17
3.4
2.4
1106.81
3453.69
u/l
—
9
68
415
4004
2.12
2.10
34.3
19.5
39.91
40.22
%
0.59
395
3789
122
973
1.35
2.07
1.7
1.7
1.37
1.35
mmol/l
0.10
96
818
20
104
1.97
2.04
1.1
1.1
—
—
—
0
0
97
748
1.38
2.03
2.2
1.9
—
—
—
0
0
14
63
2.26
2.03
1.8
1.6
—
—
—
0
0
11
44
2.54
2.02
2.0
1.5
—
—
—
0
0
29
172
1.74
1.99
2.0
2.3
—
—
—
0
0
367
3445
1.45
1.99
5.4
4.4
5.89
5.89
mmol/l
0.00
335
3170
9
33
2.76
1.94
2.1
2.6
—
—
—
0
0
124
1007
1.33
1.85
4.5
4.0
13.44
8.92
mg/mmol
0.44
74
636
5
12
4.20
1.83
1.2
1.6
168.40
140.08
nmol/l
—
5
12
63
462
1.43
1.76
1.3
1.2
—
—
—
0
0
6
18
3.37
1.75
6.0
7.8
—
—
—
0
0
9
36
2.53
1.75
1.7
2.7
—
—
—
0
0
129
1063
1.31
1.72
3.7
3.2
7.00
7.75
mmol/l
1.15
102
902
118
961
1.31
1.72
3.6
3.3
623.74
52.20
mg/l
0.52
74
625
22
126
1.79
1.71
4.4
3.7
0.36
0.17
g/l
—
10
55
6
19
3.19
1.66
1.7
1.1
—
—
—
0
0
11
49
2.28
1.65
1.9
3.1
—
—
—
0
0
5
14
3.60
1.62
2.4
2.3
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
2.0
2.1
762.80
871.86
u/ml
—
5
14
24
383
0.60
1.62
1.6
1.4
—
—
—
0
0
6
20
3.03
1.58
4.5
2.8
40.03
11.73
mu/l
—
6
20
21
122
1.76
1.57
1.5
1.6
—
—
—
0
0
10
44
2.30
1.56
1.0
1.2
—
—
—
0
0
5
15
3.36
1.52
1.6
1.3
—
—
—
0
0
23
139
1.69
1.51
1.3
1.6
—
10.08
—
0
5
18
101
1.82
1.51
1.7
2.8
—
—
—
0
0
22
133
1.69
1.45
1.7
1.8
—
—
—
0
0
17
95
1.82
1.45
1.1
1.4
384.62
295.52
ug/g
—
8
52
21
127
1.69
1.39
1.1
1.2
—
—
—
0
0
9
41
2.22
1.37
1.3
1.2
—
—
—
0
0
14
75
1.90
1.36
1.1
1.4
—
—
—
0
0
9
42
2.17
1.34
1.6
1.2
—
—
—
0
0
13
69
1.91
1.30
1.1
1.1
—
—
—
0
0
13
69
1.91
1.30
1.8
1.4
—
—
—
0
0
13
69
1.91
1.30
1.1
1.1
—
—
—
0
0
125
1068
1.24
1.21
1.7
1.5
—
—
—
0
0
11
57
1.95
1.18
1.1
1.1
—
—
—
0
0
7
31
2.28
1.11
2.9
2.1
0.23
0.21
e9/l
—
7
26
12
66
1.84
1.10
6.7
2.5
—
—
—
0
0
37
271
1.40
1.09
5.1
3.4
—
—
—
0
0
7
32
2.21
1.08
2.7
2.0
739.71
507.54
e6/l
—
7
26
11
59
1.89
1.08
1.0
1.1
—
—
—
0
0
7
34
2.08
1.03
2.3
1.6
—
—
—
0
0
16
99
1.64
1.01
2.7
1.9
—
—
—
0
0
9
49
1.85
0.99
1.0
1.1
—
—
—
0
0
51
402
1.30
0.96
1.6
1.5
—
—
—
0
0
19
126
1.53
0.93
1.4
2.8
20.85
21.82
s
0.43
13
113
110
956
1.20
0.90
6.0
4.8
2.16
2.45
ug/l
0.24
92
856
6
31
1.95
0.84
1.0
1.1
—
4.75
—
0
12
19
131
1.47
0.79
1.9
2.7
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.4
—
9.25
—
0
24
0
25
0.00
0.79
0.0
1.7
—
—
—
0
0
0
26
0.00
0.78
0.0
1.0
—
5.24
—
0
7
6
34
1.78
0.76
1.0
1.1
—
—
—
0
0
5
24
2.10
0.74
1.0
1.2
—
—
—
0
0
5
24
2.10
0.74
1.8
1.4
—
—
—
0
0
22
159
1.40
0.74
1.1
1.1
—
—
—
0
0
89
775
1.19
0.72
5.6
3.8
1.02
1.02
kg/l
—
7
106
30
230
1.33
0.71
1.3
1.2
—
—
—
0
0
5
27
1.86
0.68
1.4
1.4
—
—
—
0
0
15
102
1.49
0.68
1.3
1.3
—
—
—
0
0
52
432
1.23
0.68
2.3
1.7
—
—
—
0
0
362
3512
1.20
0.66
5.1
4.3
4.66
4.69
mmol/l
0.21
334
3274
8
51
1.58
0.60
1.0
1.2
—
—
—
0
0
348
3376
1.16
0.57
4.6
3.8
1.36
1.28
mmol/l
0.98
317
3124
25
194
1.31
0.57
3.5
2.6
0.16
0.11
e6/l
0.20
25
185
6
38
1.59
0.54
1.0
1.3
—
—
—
0
0
6
38
1.59
0.54
1.2
1.1
—
—
—
0
0
359
3495
1.17
0.54
5.1
4.3
1.46
1.48
mmol/l
0.46
328
3242
6
39
1.55
0.53
1.2
1.1
1.66
1.43
g/l
—
6
34
366
3574
1.16
0.50
5.4
4.8
2.72
2.78
mmol/l
0.57
334
3313
7
106
0.65
0.49
1.6
1.4
—
—
—
0
0
7
106
0.65
0.49
1.7
1.4
—
—
—
0
0
7
109
0.64
0.49
1.7
1.5
—
—
—
0
0
145
1346
1.12
0.48
3.3
2.8
—
—
—
0
0
20
155
1.30
0.47
2.9
2.7
1.39
1.15
%
0.43
20
155
5
33
1.52
0.41
1.0
1.0
—
0.07
—
0
12
8
59
1.36
0.41
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.2
3.3
1.34
7.54
nmol/l
—
5
35
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
6
43
1.40
0.35
1.3
1.9
32.17
32.95
pg
—
6
43
6
43
1.40
0.35
2.0
2.6
—
—
—
0
0
6
46
1.31
0.33
1.5
2.1
—
—
—
0
0
20
239
0.83
0.30
1.6
1.4
—
—
—
0
0
7
55
1.28
0.30
1.7
1.8
—
—
—
0
0
18
148
1.23
0.29
3.0
2.7
0.66
0.65
%
0.09
18
148
9
74
1.22
0.25
1.0
1.6
—
—
—
0
0
7
93
0.75
0.22
5.7
4.4
—
—
—
0
0
5
41
1.22
0.22
1.6
1.1
—
—
nmol/l
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
14
166
0.84
0.21
4.6
3.4
—
—
—
0
0
9
114
0.79
0.20
16.7
8.8
—
—
—
0
0
17
197
0.86
0.20
1.8
1.8
—
—
—
0
0
15
127
1.19
0.20
1.5
1.4
—
—
—
0
0
17
146
1.17
0.19
2.3
1.4
—
—
—
0
0
10
82
1.22
0.17
2.0
2.5
—
—
—
0
0
20
220
0.90
0.12
2.3
2.5
—
—
—
0
0
17
153
1.12
0.11
2.3
1.4
—
—
—
0
0
17
154
1.11
0.10
2.3
1.4
—
—
—
0
0
5
45
1.11
0.10
1.4
1.1
—
—
—
0
0
10
87
1.15
0.09
1.0
1.1
—
—
—
0
0
17
155
1.10
0.09
2.4
1.4
—
—
—
0
0
40
419
0.95
0.08
2.0
1.7
—
—
—
0
0
7
66
1.06
0.08
3.1
3.0
—
—
—
0
0
7
84
0.83
0.07
1.0
1.2
—
—
—
0
0
11
99
1.11
0.06
1.3
1.2
—
—
—
0
0
14
131
1.07
0.03
1.2
1.4
176.99
259.96
miu/ml
—
5
70
57
563
1.01
0.01
3.3
3.0
0.73
0.73
ug/l
0.02
40
364
15
154
0.97
0.00
2.5
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
3.38
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
18.13
—
0
6
0
5
0.00
-0.00
0.0
2.0
—
10950.80
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
38.00
—
0
6
0
6
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.8
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM and mortality.

Females

Parameter HR [95% CI] p-value
LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM 1.557 [1.26, 1.93] < 0.001
Birth year 0.998 [0.99, 1.01] 0.626

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 1248 females with LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM died.

Males

Parameter HR [95% CI] p-value
LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM 1.561 [1.26, 1.93] < 0.001
Birth year 0.99 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 969 males with LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM died.

Mortality risk

Mortality risk for people of age

years, who have LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM.

N-year risk Females Males
1 0.143% 0.415%
5 1.089% 2.227%
10 2.717% 5.267%
15 4.883% 9.734%
20 8.541% 15.853%

Relationships between endpoints

↥

Index endpoint: LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM – Localized skin eruption due to drugs and medicaments

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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