anus disease: A non-neoplastic or neoplastic disorder that affects the anal canal or anal margin. Representative examples of non-neoplastic disorders include hemorrhoids and anal ulcer. Representative examples of neoplastic disorders include carcinoma, lymphoma, and melanoma. [database_cross_reference: NCIT:C26695]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
908 |
4. Check minimum number of eventsNone |
908 |
5. Include endpointsNone |
908 |
6. Filter based on genotype QC (FinnGen only) |
908 |
Control definitions (FinnGen only)
- Control exclude
- N14_FEMALEGENINF
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Ulcer of vagina/vulva
based on the number of shared cases.
Similar with more cases:
- Inflammatory diseases of female pelvic organs
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5605 | 5605 | - |
| Only index persons | 5168 | 5168 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | - |
| Only index persons | 0.19 | 0.19 | - |
| Median age at first event (years) | |||
| Whole population | - | 46.23 | - |
| Only index persons | - | 48.21 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 908 | 908 | - |
| Unadjusted period prevalence (%) | 0.31 | 0.31 | - |
| Median age at first event (years) | 52.29 | 52.29 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 772
- Matched controls
- 7720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N76.6
ICD-10 Finland
Ulceration of vulva
1114.8
323.0
542
16
N76.5
ICD-10 Finland
Ulceration of vagina
1224.2
272.2
250
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
24.8
141.2
205
111
ULA02
NOMESCO Finland
Kolposcopy
6.6
91.6
276
597
D07AD01
ATC
clobetasol; topical
4.6
55.9
230
656
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.4
54.3
415
1988
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
11.1
51.5
101
103
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.8
44.6
223
741
LEB00
NOMESCO Finland
Biopsy of vagina
11.6
40.5
77
73
J02AC01
ATC
fluconazole; systemic
2.7
37.6
470
2833
N76.3
ICD-10 Finland
Subacute and chronic vulvitis
31.4
27.4
36
12
P01AB01
ATC
metronidazole; oral, rectal
2.2
24.3
369
2250
D07AB02
ATC
hydrocortisone butyrate; topical
2.3
23.5
274
1468
N76.0
ICD-10 Finland
Acute vaginitis
4.0
22.2
94
259
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
22.1
344
2093
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
14.6
21.0
35
25
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.7
20.4
158
673
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
7.2
19.8
48
70
N76.2
ICD-10 Finland
Acute vulvitis
41.3
19.6
24
6
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
19.4
204
1021
E0000UV
ATC
NA
2.0
18.6
360
2341
J05AB11
ATC
valaciclovir; oral
2.7
18.5
140
584
LFC00
NOMESCO Finland
Partial excision of vulva
29.6
17.5
23
8
G01AA10
ATC
clindamycin; vaginal
2.3
16.9
189
968
LCA06
NOMESCO Finland
Biopsy of endometrium
2.5
16.9
147
662
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.9
16.2
431
3095
D07AC01
ATC
betamethasone; topical
2.0
15.6
276
1703
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
7.1
15.3
37
54
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
15.3
239
1402
J01DB01
ATC
cefalexin; oral
2.1
14.9
641
5398
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
57.8
14.8
17
*
H02AB06
ATC
prednisolone; systemic
1.8
14.6
356
2449
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.3
14.3
143
689
A02BC02
ATC
pantoprazole; systemic
1.8
14.1
480
3667
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.3
13.9
134
634
N76.8
ICD-10 Finland
Other specified inflammation of vagina and vulva
11.7
13.9
25
22
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
76.5
13.6
15
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
2.7
13.1
97
395
M35.2
ICD-10 Finland
Behçet disease
+∞
12.5
12
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
12.5
94
389
J05AB01
ATC
aciclovir; systemic
2.0
12.4
199
1167
C05AA08
ATC
fluocortolone; rectal, topical
2.3
12.2
116
541
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
6.0
12.2
33
57
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
12.1
203
1210
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
11.7
288
1945
M25.5
ICD-10 Finland
Pain in joint
1.8
11.4
240
1539
L43.9
ICD-10 Finland
Lichen planus, unspecified
6.1
11.3
30
51
J01MA02
ATC
ciprofloxacin; systemic
1.8
11.0
268
1796
UKC02
NOMESCO Finland
Cystoscopy
2.5
11.0
88
375
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
7.6
11.0
25
34
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
2.2
11.0
120
599
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.7
10.9
78
311
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
10.9
287
1969
L29.2
ICD-10 Finland
Pruritus vulvae
5.5
10.8
31
58
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
10.7
203
1251
N94.1
ICD-10 Finland
Dyspareunia
5.2
10.6
32
64
N06AX11
ATC
mirtazapine; oral
1.8
10.6
252
1674
X15
ICPC
Vaginal symptom/complaint other
3.0
10.3
60
212
UJF32
NOMESCO Finland
Coloscopy
1.9
10.3
176
1048
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
10.2
10.1
19
19
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
40.6
10.0
12
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
10.0
655
5775
J01FF01
ATC
clindamycin; systemic
1.8
9.9
192
1188
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
17.0
9.9
15
9
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.7
275
1909
R01AD09
ATC
mometasone; nasal
1.6
9.6
362
2718
N77.1*B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
5.3
9.6
28
54
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
2.9
9.5
59
217
E000006
ATC
NA
2.5
9.5
76
326
U02
ICPC
Urinary frequency/urgency
2.0
9.2
133
742
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
7.9
9.2
20
26
A02BC03
ATC
lansoprazole; oral
1.7
9.2
202
1301
N03AX16
ATC
pregabalin; oral
1.8
9.1
171
1045
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
7.6
9.0
20
27
N30.0
ICD-10 Finland
Acute cystitis
1.9
8.9
141
812
N95.0
ICD-10 Finland
Postmenopausal bleeding
2.3
8.9
88
417
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.4
8.9
42
129
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.8
8.8
186
1178
N06AX21
ATC
duloxetine; oral
2.2
8.8
94
461
N30
ICD-10 Finland
Cystitis
2.3
8.8
85
399
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
8.8
376
2893
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
2.6
8.7
62
248
R51.80
ICD-10 Finland
Headache
1.9
8.7
139
802
WX400
NOMESCO Finland
Inhalation anesthesy
3.0
8.7
49
168
J01EA01
ATC
trimethoprim; systemic
1.7
8.7
235
1601
B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
4.7
8.7
28
61
J01CA08
ATC
pivmecillinam; oral
1.6
8.6
416
3291
61610
ICD-8 Finland
Diseases of parametrium and pelvic peritoneum (female), Pelvic peritoneal adhesions, female
+∞
8.3
8
*
M01AH05
ATC
etoricoxib; oral
1.6
8.1
411
3269
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
33.7
8.1
10
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
8.0
99
517
U07
ICPC
Urine symptom/complaint other
2.7
8.0
54
208
S31.4
ICD-10 Finland
Open wound of vagina and vulva
22.3
8.0
11
5
J01FA10
ATC
azithromycin; systemic
1.6
8.0
481
3978
R06AX27
ATC
desloratadine; oral
1.6
7.9
235
1637
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
2.5
7.8
61
259
N76.4
ICD-10 Finland
Abscess of vulva
10.9
7.8
14
13
L43.8
ICD-10 Finland
Other lichen planus
4.5
7.8
26
59
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.6
7.6
53
212
LWW96
NOMESCO Finland
Other reoperation in gynaecological surgery
12.0
7.6
13
11
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
7.6
210
1432
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
25.3
7.6
10
*
JAH01
NOMESCO Finland
Laparoscopy
2.9
7.4
44
160
A02BC05
ATC
esomeprazole; systemic
1.6
7.4
284
2105
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.1
7.3
78
385
AA1AD
NOMESCO Finland
CT of head and brain
1.8
7.3
142
872
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
7.3
139
850
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
7.3
199
1352
K60.2
ICD-10 Finland
Anal fissure, unspecified
5.9
7.3
19
33
N75.1
ICD-10 Finland
Abscess of Bartholin gland
15.9
7.2
11
7
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
7.2
93
495
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
7.2
258
1875
B00.9
ICD-10 Finland
Herpesviral infection, unspecified
8.9
7.1
14
16
E000001
ATC
NA
1.7
6.9
170
1119
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.5
6.9
30
88
H02AB04
ATC
methylprednisolone; systemic
1.9
6.9
104
590
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.9
6.8
98
544
N81.1
ICD-10 Finland
Cystocele
2.1
6.8
72
355
N39.3
ICD-10 Finland
Stress incontinence
2.1
6.7
71
348
L02
ICPC
Back symptom/complaint
2.0
6.7
86
459
A03FA01
ATC
metoclopramide; systemic, rectal
1.7
6.7
164
1078
M35.7
ICD-10 Finland
Hypermobility syndrome
4.5
6.7
22
50
LEG12
NOMESCO Finland
Transobturatoric tape
4.5
6.7
22
50
N77.1
ICD-10 Finland
Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere
6.5
6.7
16
25
G04BD08
ATC
solifenacin; oral
2.5
6.6
50
209
M79.6
ICD-10 Finland
Pain in limb
1.5
6.6
264
1960
K30
ICD-10 Finland
Functional dyspepsia
2.0
6.6
87
469
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
6.5
58
265
R33
ICD-10 Finland
Retention of urine
3.5
6.5
28
82
X29
ICPC
Genital sympt/compl female other
4.3
6.5
22
52
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.9
6.4
89
485
N77.1*A60.0
ICD-10 Finland
Vaginitis, vulvitis and vulvovaginitis in herpesviral [herpes simplex] infection
14.4
6.4
10
7
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
6.3
56
252
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
5.2
6.3
18
35
R03AC02
ATC
salbutamol; inhalant
1.5
6.3
401
3275
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
6.3
240
1760
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.1
6.3
66
324
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
6.3
133
838
L15
ICPC
Knee symptom/complaint
1.6
6.3
154
1014
61207
ICD-8 Finland
Acute salpingitis and oophoritis, suspecta
+∞
6.3
6
*
N77.8*M35.2
ICD-10 Finland
Ulceration of vulva in Behçet's disease
+∞
6.3
6
*
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
+∞
6.3
6
*
J01FA06
ATC
roxithromycin; oral
1.5
6.3
285
2174
M54.5
ICD-10 Finland
Low back pain
1.5
6.2
250
1853
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
26.9
6.2
8
*
LEE00
NOMESCO Finland
Suture of vagina
26.9
6.2
8
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
6.2
97
556
R42
ICD-10 Finland
Dizziness and giddiness
1.7
6.2
149
973
J01MA12
ATC
levofloxacin; systemic
1.8
6.2
107
635
B01AB05
ATC
enoxaparin; parenteral
1.6
6.2
200
1413
D07CC01
ATC
betamethasone and antibiotics; topical
1.8
6.2
98
565
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.2
174
1186
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.8
6.1
99
573
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.7
6.1
39
147
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
6.1
64
313
K12.00
ICD-10 Finland
Recurrent oral aphthae
4.4
6.1
20
46
M01AB05
ATC
diclofenac; systemic, rectal
1.5
6.0
452
3805
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
82
7.35
38.10
1.3
1.1
—
—
—
0
0
385
2158
2.36
33.77
1.7
1.5
—
—
—
0
0
390
2439
2.05
23.80
3.5
3.0
—
—
—
0
0
694
5375
2.24
23.28
6.8
4.3
2050.5
3094.1
e6/l
—
8
69
21
17
12.62
21.25
1.0
1.0
—
—
—
0
0
21
17
12.62
21.25
2.1
2.4
1.9
2.1
ug/l
—
16
8
345
2148
1.98
20.59
2.3
2.2
54.0
56.5
u/l
0.77
306
1955
547
4000
1.92
19.87
4.7
3.6
0.0
0.0
estimate
0.50
110
752
542
3974
1.90
19.28
6.1
4.8
0.0
0.0
estimate
0.50
111
763
692
5576
2.01
17.71
7.9
6.5
73.6
74.9
u/l
0.49
655
5209
304
1910
1.89
16.97
3.5
2.8
0.2
0.4
e6/l
1.90
233
1413
527
3952
1.79
16.17
4.7
3.5
0.0
0.0
estimate
0.00
111
754
570
4383
1.81
15.98
9.2
8.2
3.9
3.9
e9/l
0.01
508
3874
420
2955
1.78
15.95
4.5
4.0
35.9
36.0
g/l
0.12
386
2727
438
3127
1.77
15.76
4.9
4.8
1.2
1.2
mmol/l
0.32
396
2821
690
5651
1.92
15.52
5.1
3.9
12.1
11.5
mm/h
0.55
647
5225
193
1070
2.02
15.39
2.4
2.3
148.9
106.3
ug/g
0.60
155
820
157
810
2.13
15.17
2.2
1.7
—
—
—
0
0
487
3620
1.74
14.92
5.2
5.1
9.4
10.1
umol/l
1.50
454
3406
97
414
2.50
14.58
1.6
1.4
—
—
—
0
0
41
109
3.89
13.82
1.4
1.3
—
—
—
0
0
462
3443
1.70
13.52
5.6
5.5
1.2
1.2
mmol/l
0.07
375
2895
856
7719
2.90
13.48
16.3
11.5
20.1
20.1
mg/l
0.00
705
5944
236
1456
1.84
13.46
2.7
2.4
7.8
9.2
e6/l
0.63
198
1288
182
1034
1.95
13.37
2.5
1.9
—
—
—
0
0
298
1976
1.76
13.31
2.1
2.1
110.2
177.7
u/l
1.29
278
1860
181
1038
1.93
12.90
3.2
2.6
4.7
4.5
e6/l
0.07
108
509
25
48
5.33
12.54
2.4
1.7
—
—
—
0
0
395
2886
1.65
12.00
2.2
1.9
101.3
97.5
pmol/l
0.69
207
1427
241
1542
1.77
11.99
2.6
2.2
—
—
—
0
0
264
1754
1.71
11.40
1.9
1.7
0.8
1.0
mg/l
2.08
197
1314
598
4904
1.64
11.01
3.1
2.7
35.7
35.8
u/l
0.01
554
4606
217
1384
1.75
10.77
2.5
2.0
—
—
—
0
0
46
156
3.05
10.71
4.2
3.7
56.6
58.4
%
0.42
46
156
185
1131
1.80
10.61
3.2
2.4
1.5
1.1
e6/l
0.29
112
598
514
4107
1.58
10.15
4.1
3.9
6.3
6.4
mmol/l
0.51
476
3704
331
2390
1.61
10.09
3.7
3.2
27.8
45.9
ng/l
0.47
190
1419
44
151
3.01
10.05
4.2
3.5
4.0
4.3
e9/l
0.35
44
151
838
7645
2.25
9.96
16.6
12.7
139.5
139.6
mmol/l
0.06
825
7417
23
51
4.60
9.81
1.2
1.3
—
—
—
0
0
127
706
1.93
9.78
1.8
2.1
379.1
383.3
nmol/l
0.08
116
646
838
7665
2.21
9.55
16.8
12.8
3.9
3.9
mmol/l
0.66
823
7416
326
2372
1.58
9.50
3.4
2.8
27.1
28.1
u/l
0.39
303
2250
746
6584
1.75
9.34
5.1
4.4
14.6
14.6
pmol/l
0.03
697
6034
220
1462
1.67
9.23
1.3
1.3
22.2
31.1
iu/ml
0.97
64
458
131
752
1.87
9.13
2.6
2.5
4.9
5.8
umol/l
0.75
111
619
395
3022
1.54
9.12
4.9
3.7
—
—
—
0
0
165
1017
1.76
9.10
3.0
2.9
0.8
0.8
mmol/l
0.15
153
944
212
1405
1.66
8.96
1.4
1.2
6.8
11.7
u/ml
0.90
79
545
187
1207
1.69
8.71
3.2
3.5
44.6
345.4
ng/l
3.19
123
826
341
2558
1.53
8.44
3.1
3.2
2.3
2.4
mmol/l
1.81
298
2250
17
33
5.23
8.43
1.0
1.2
—
—
—
0
0
91
478
2.00
8.24
1.3
1.3
25.0
23.6
iu/l
0.13
78
413
102
560
1.93
8.13
3.1
3.3
26.2
60.4
u/ml
2.07
93
536
189
1246
1.65
8.07
1.7
1.7
1212.6
1197.4
nmol/l
0.08
155
926
864
8078
2.44
8.05
12.2
9.2
23.1
22.9
u/l
0.16
841
7781
148
918
1.73
7.93
2.3
2.1
2.4
2.4
g/l
0.22
134
848
284
2083
1.53
7.65
1.4
1.3
0.6
2.0
u/ml
3.04
75
543
86
458
1.97
7.49
1.6
1.6
—
—
—
0
0
267
1940
1.53
7.48
2.0
1.6
—
—
—
0
0
159
1022
1.67
7.45
2.2
2.1
13.2
13.5
umol/l
0.18
147
937
51
224
2.35
7.23
1.4
1.3
—
—
—
0
0
425
3411
1.46
7.23
2.5
2.3
82.1
77.4
nmol/l
2.45
393
3077
135
841
1.71
7.09
2.5
2.2
22.3
22.3
%
0.00
118
709
59
281
2.18
6.93
1.8
1.8
—
—
—
0
0
457
3744
1.44
6.84
4.6
3.9
—
—
—
0
0
147
947
1.66
6.80
2.5
2.0
30.5
29.2
s
1.67
138
916
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
16
36
4.51
6.72
1.0
1.2
—
—
—
0
0
282
2129
1.47
6.40
5.4
3.8
0.0
0.0
estimate
1.08
107
763
41
173
2.43
6.37
1.0
1.4
3.7
3.7
mmol/l
0.04
36
162
95
554
1.80
6.27
1.5
1.2
1200.9
219.5
u/ml
0.47
90
510
48
219
2.26
6.27
1.2
1.1
—
—
—
0
0
807
7474
1.72
6.16
6.3
5.2
1.8
2.0
mu/l
0.84
768
6941
39
164
2.44
6.12
1.4
1.4
—
—
—
0
0
48
222
2.23
6.08
1.8
1.5
—
—
—
0
0
18
49
3.73
5.94
2.1
2.0
—
—
—
0
0
108
667
1.70
5.84
3.6
4.4
225.2
251.4
u/l
1.19
100
626
40
174
2.36
5.84
1.1
1.4
28.9
10.0
e6/l
0.38
24
136
40
174
2.36
5.84
1.2
1.5
1229.3
123.3
e6/l
0.50
26
144
255
1917
1.46
5.83
2.3
2.1
2.9
2.9
mg/l
0.05
223
1615
47
222
2.18
5.67
2.2
2.7
173.3
178.9
%
0.16
41
211
78
445
1.82
5.54
2.0
1.7
—
—
—
0
0
82
476
1.79
5.51
2.3
2.6
68.1
66.8
g/l
0.96
76
436
148
1005
1.56
5.48
1.8
1.8
—
—
—
0
0
18
53
3.44
5.32
1.8
2.0
11.8
11.3
%
0.07
13
31
12
26
4.66
5.27
1.2
1.6
—
—
—
0
0
74
423
1.82
5.23
1.4
1.6
397.3
299.7
mu/l
0.83
62
367
468
3970
1.37
5.14
3.6
2.8
71.6
73.4
ug/l
0.14
443
3666
226
1705
1.43
4.97
4.7
3.9
1.0
1.0
kg/l
0.01
31
260
765
7082
1.51
4.84
14.2
10.6
86.2
85.5
ml/min/173m2
0.37
647
5648
721
6603
1.45
4.77
5.5
5.0
38.4
38.5
mmol/mol
0.13
677
6130
216
1631
1.43
4.70
1.6
1.4
22.0
22.1
nmol/l
0.03
191
1391
183
1344
1.45
4.62
3.3
2.6
2.5
2.4
mmol/l
0.08
161
1182
107
710
1.57
4.37
1.7
1.7
—
—
—
0
0
728
6718
1.42
4.28
20.1
14.3
13.5
13.5
%
0.23
721
6569
87
552
1.64
4.27
2.4
2.4
54.2
24.1
au/ml
—
9
33
103
684
1.57
4.20
2.2
2.2
28.4
35.5
u/l
1.47
87
571
774
7232
1.48
4.17
4.5
4.1
5.7
5.7
mmol/l
0.00
722
6615
48
260
1.89
4.06
2.0
1.9
—
—
—
0
0
105
706
1.55
4.06
1.7
1.7
—
—
—
0
0
45
239
1.93
4.04
1.2
1.3
14.8
11.8
u/l
0.43
36
196
29
132
2.24
3.90
1.1
1.1
—
—
—
0
0
30
139
2.20
3.87
1.3
1.2
7.0
5.4
u/ml
0.11
14
61
103
700
1.53
3.80
2.9
2.9
—
—
—
0
0
772
7241
1.44
3.77
18.1
12.8
39.2
39.0
%
0.35
573
5441
32
157
2.08
3.59
2.9
4.1
33.9
52.2
mg/l
0.36
22
123
32
157
2.08
3.59
2.9
4.1
28.4
40.1
mg/l
1.16
22
124
91
610
1.55
3.58
2.3
2.2
1441.5
6104.3
u/l
2.98
31
267
27
125
2.20
3.51
2.7
2.1
16.7
15.8
%
0.54
11
56
113
804
1.46
3.35
1.6
1.5
1.4
1.3
%
0.22
99
713
247
2003
1.32
3.32
3.0
3.1
6.5
6.8
mmol/l
0.39
212
1695
87
589
1.53
3.28
3.4
2.9
1.2
1.2
mmol/l
0.16
76
495
13
43
3.05
3.26
1.1
1.1
—
—
—
0
0
10
28
3.60
3.20
1.0
1.3
—
—
—
0
0
193
1519
1.34
3.18
1.6
1.7
39103035.1
27316740.2
pmol/l
0.11
156
1252
87
596
1.51
3.12
3.4
3.3
4.4
4.5
pmol/l
1.07
78
533
210
1681
1.32
3.08
3.0
2.9
913.2
1033.9
ng/l
0.30
174
1394
7
12
5.87
3.02
1.3
1.1
—
—
—
0
0
30
155
1.97
2.97
1.5
1.3
—
—
—
0
0
618
5676
1.28
2.96
4.1
3.5
—
—
—
0
0
36
199
1.84
2.93
1.5
1.4
287.1
312.4
ug/g
0.20
14
115
69
456
1.56
2.92
2.9
2.8
105.1
198.4
ng/l
3.04
60
418
44
260
1.73
2.88
1.3
1.3
—
—
—
0
0
28
143
1.99
2.87
1.3
1.2
11.3
3.1
u/ml
—
7
50
9
23
3.94
2.78
1.1
1.1
89.6
99.1
%
—
9
23
9
23
3.94
2.78
1.1
1.1
—
—
—
0
0
67
448
1.54
2.71
2.2
2.4
5.7
5.8
ug/l
0.02
53
389
37
213
1.77
2.67
2.0
2.8
3.6
3.7
g/l
0.20
32
206
35
201
1.77
2.55
2.4
2.4
0.4
0.7
g/l
0.41
30
179
5
7
7.18
2.55
1.0
1.6
—
—
—
0
0
231
1918
1.27
2.53
1.7
1.6
1.3
1.3
mmol/l
0.00
194
1632
222
1844
1.27
2.42
3.8
4.0
8.3
7.9
mg/mmol
0.04
121
1086
106
794
1.38
2.40
4.0
4.4
1.0
1.0
mmol/l
0.06
100
718
27
146
1.88
2.39
1.3
1.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
7
17
4.14
2.36
1.0
1.2
—
71.8
—
0
5
7
17
4.14
2.36
1.0
1.1
—
90.4
—
0
5
32
184
1.77
2.34
1.3
1.5
0.5
0.4
nmol/l
0.21
24
154
42
261
1.64
2.33
1.2
1.1
—
—
—
0
0
20
98
2.06
2.33
1.4
1.8
1.5
1.7
mmol/l
0.84
20
98
86
627
1.41
2.29
5.0
6.2
0.7
1.2
mmol/l
0.63
64
503
15
66
2.29
2.25
1.3
1.1
—
—
—
0
0
15
66
2.29
2.25
1.3
1.1
—
—
—
0
0
101
759
1.37
2.25
1.2
1.2
190.2
148.1
iu/ml
0.29
35
310
83
606
1.41
2.20
2.1
2.1
0.2
0.2
g/l
1.39
77
568
76
548
1.42
2.16
2.5
3.4
82.0
77.4
ng/l
0.18
63
474
41
259
1.61
2.16
1.1
1.1
—
—
—
0
0
6
14
4.31
2.15
1.0
1.1
—
—
—
0
0
36
220
1.66
2.15
2.2
2.2
10.2
9.9
g/l
0.13
30
193
37
228
1.65
2.14
2.2
2.2
7.6
7.6
g/l
0.01
29
181
37
228
1.65
2.14
2.2
2.2
3.9
3.6
g/l
1.12
28
176
37
228
1.65
2.14
2.2
2.2
—
—
—
0
0
17
81
2.12
2.13
4.1
3.3
2.0
1.0
%
0.26
12
62
199
1656
1.26
2.12
2.2
2.4
306.8
5975.1
umol/l
6.27
174
1435
29
168
1.75
2.10
1.6
1.2
—
—
—
0
0
8
25
3.22
2.10
1.1
1.3
—
—
—
0
0
35
214
1.66
2.09
2.3
2.2
3.1
3.2
g/l
0.03
28
179
21
110
1.93
2.07
1.6
1.7
—
—
—
0
0
26
147
1.79
2.04
1.5
1.4
214.0
246.6
u/ml
0.30
20
87
13
57
2.30
1.98
7.6
5.4
13.5
11.9
mg/l
0.60
13
52
8
27
2.98
1.94
1.0
1.0
—
—
—
0
0
24
136
1.79
1.88
1.2
1.4
—
—
—
0
0
24
136
1.79
1.88
1.2
1.4
—
—
—
0
0
45
303
1.51
1.83
4.6
3.2
24.9
24.2
mmol/l
0.66
39
269
75
557
1.38
1.83
3.8
3.1
2.3
2.1
mmol/l
0.16
62
444
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
169
1.68
1.79
2.1
3.7
0.4
0.4
u/ml
—
10
99
14
67
2.11
1.76
1.3
1.1
—
—
—
0
0
14
67
2.11
1.76
1.3
1.1
—
—
—
0
0
14
67
2.11
1.76
1.3
1.1
—
—
—
0
0
39
257
1.54
1.76
1.5
2.2
1.5
1.5
g/l
0.15
32
225
82
623
1.35
1.74
3.1
3.7
13.3
10.5
ug/l
0.13
60
493
209
1788
1.22
1.72
2.6
2.0
—
—
—
0
0
54
388
1.42
1.62
1.4
1.4
—
—
—
0
0
5
14
3.58
1.61
1.2
2.4
—
—
—
0
0
90
704
1.31
1.59
32.7
23.5
1.3
1.2
inr
—
9
104
31
199
1.58
1.58
1.5
1.6
—
108.6
—
0
7
24
147
1.65
1.48
2.2
2.0
—
—
—
0
0
7
28
2.51
1.45
1.0
1.1
—
—
—
0
0
11
52
2.13
1.45
1.4
1.4
—
—
—
0
0
13
66
1.98
1.44
1.5
2.0
28.6
31.0
pg
0.75
13
66
66
504
1.33
1.40
1.1
1.0
—
—
—
0
0
7
29
2.42
1.39
1.1
1.3
—
—
—
0
0
23
143
1.62
1.36
1.4
1.4
—
—
—
0
0
0
37
0.00
1.34
0.0
2.4
—
52.5
—
0
28
11
54
2.05
1.33
1.2
1.2
—
—
—
0
0
9
43
2.10
1.30
1.1
1.3
—
—
—
0
0
23
145
1.60
1.30
1.3
1.4
—
—
—
0
0
11
55
2.01
1.27
1.2
1.1
—
—
—
0
0
11
55
2.01
1.27
1.2
1.2
—
—
—
0
0
752
7275
1.20
1.25
4.2
3.9
1.5
1.6
mmol/l
2.84
707
6758
8
36
2.23
1.24
2.8
3.0
369.3
1292.7
u/ml
—
8
36
25
163
1.55
1.24
2.6
4.2
1.5
1.4
mg/l
0.21
25
146
71
560
1.29
1.22
1.4
1.4
—
—
—
0
0
756
7321
1.20
1.22
4.3
3.9
4.7
4.8
mmol/l
2.66
719
6822
13
71
1.84
1.20
1.2
1.5
—
—
—
0
0
0
33
0.00
1.16
0.0
1.1
—
—
—
0
0
48
361
1.35
1.16
1.9
1.6
—
—
—
0
0
28
191
1.48
1.15
1.2
1.1
0.7
2.1
u/ml
0.86
12
67
10
51
1.97
1.11
1.1
1.1
1.0
1.1
ratio
—
5
23
32
226
1.43
1.11
1.5
1.2
3.3
9.0
u/ml
—
5
43
13
73
1.79
1.11
1.1
1.1
—
—
—
0
0
33
237
1.41
1.06
1.5
1.6
0.0
0.3
iu/ml
—
8
41
5
22
2.28
1.03
2.8
1.2
8.0
8.5
ug/l
—
5
22
18
115
1.58
1.00
1.2
1.1
—
—
—
0
0
765
7446
1.17
1.00
4.9
4.4
2.7
2.8
mmol/l
2.26
719
6899
13
76
1.72
0.99
1.6
1.8
42.5
57.8
%
—
8
44
5
23
2.18
0.98
1.2
1.2
—
—
—
0
0
17
108
1.59
0.97
1.2
1.2
—
—
—
0
0
9
50
1.81
0.96
1.1
1.6
—
—
—
0
0
12
69
1.75
0.96
1.2
1.2
0.0
1.3
u/ml
—
6
24
28
199
1.42
0.96
1.6
2.1
5.5
4.5
umol/l
0.26
22
144
717
6955
1.15
0.93
3.8
3.5
1.2
1.2
mmol/l
1.02
666
6423
26
185
1.42
0.90
1.4
1.2
25.1
34.3
u/ml
—
5
22
8
42
1.91
0.88
4.6
2.3
—
—
—
0
0
13
79
1.65
0.88
2.8
2.2
28.8
17.9
mg/l
—
5
23
16
103
1.56
0.88
1.4
1.5
—
—
—
0
0
11
65
1.70
0.82
1.4
1.4
—
—
—
0
0
15
97
1.56
0.81
1.3
1.4
—
—
—
0
0
45
358
1.27
0.78
3.1
2.6
127.6
127.4
g/l
0.03
45
350
68
568
1.21
0.78
2.1
2.5
69.5
69.5
ml/min/173m2
0.00
27
215
9
53
1.70
0.75
1.1
1.2
—
222.5
—
0
12
94
812
1.18
0.75
7.4
6.1
—
—
—
0
0
30
227
1.33
0.75
1.8
1.8
—
—
—
0
0
9
54
1.67
0.74
1.6
1.4
—
—
—
0
0
7
38
1.85
0.73
1.0
1.0
625.1
669.9
ng/l
—
7
24
49
398
1.24
0.73
1.4
1.3
187.1
244.5
miu/ml
0.66
25
197
18
125
1.45
0.73
1.0
1.1
—
—
—
0
0
13
84
1.56
0.72
1.1
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.3
—
—
—
0
0
13
86
1.52
0.66
1.1
1.5
—
—
—
0
0
10
62
1.62
0.65
1.2
1.4
—
—
—
0
0
7
44
1.60
0.65
1.0
2.0
—
—
—
0
0
34
270
1.27
0.63
1.9
2.0
4.2
5.0
iu/l
0.31
13
105
8
49
1.64
0.62
1.5
1.0
—
—
—
0
0
18
130
1.39
0.61
1.2
1.0
1.4
2.1
u/ml
—
8
62
13
88
1.48
0.60
1.1
1.1
—
—
—
0
0
21
157
1.35
0.59
1.3
1.4
—
—
—
0
0
8
53
1.51
0.58
2.9
2.1
—
—
—
0
0
11
161
0.68
0.57
5.5
3.2
33.0
25.6
mg/l
—
6
96
9
61
1.48
0.53
1.1
1.1
—
—
—
0
0
9
64
1.41
0.51
1.6
1.3
—
—
—
0
0
6
41
1.47
0.50
1.2
1.4
16.4
13.9
pmol/l
—
6
33
10
67
1.50
0.50
1.2
1.0
—
—
—
0
0
58
503
1.16
0.49
1.5
1.4
—
—
—
0
0
16
119
1.35
0.48
3.2
2.5
57.2
92.5
ug/min
0.23
11
76
58
505
1.16
0.47
1.5
1.4
—
—
—
0
0
10
68
1.48
0.47
1.2
2.0
—
—
—
0
0
12
85
1.42
0.47
1.3
1.3
—
—
—
0
0
7
48
1.46
0.47
1.0
1.0
280.6
302.2
mg/l
—
7
39
58
506
1.16
0.46
1.5
1.4
—
—
—
0
0
58
506
1.16
0.46
1.5
1.4
—
—
—
0
0
17
129
1.32
0.46
1.2
1.6
6.2
7.1
mmol/l
0.72
12
88
11
77
1.43
0.45
1.0
1.1
—
—
—
0
0
7
51
1.38
0.44
3.4
3.6
—
—
—
0
0
18
140
1.29
0.42
1.6
1.9
5326.1
17921.0
e6/l
1.41
12
97
33
277
1.20
0.41
2.3
2.7
25.3
25.4
mmol/l
0.07
33
268
5
33
1.52
0.41
1.4
1.5
—
—
—
0
0
5
33
1.52
0.41
1.4
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
30
251
1.20
0.39
2.0
1.9
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
107.4
154.5
iu/ml
—
5
35
18
142
1.27
0.38
2.9
2.4
—
—
—
0
0
9
66
1.37
0.38
1.0
1.1
172.3
199.8
mg/l
—
9
57
5
36
1.39
0.38
1.0
1.4
—
—
—
0
0
19
152
1.26
0.37
1.8
1.2
—
—
—
0
0
10
72
1.39
0.37
1.2
1.4
—
—
—
0
0
22
182
1.21
0.33
5.3
3.9
3.8
3.8
mmol/l
0.10
22
169
6
88
0.68
0.33
1.2
1.2
—
—
—
0
0
64
706
0.90
0.33
1.4
1.5
—
—
—
0
0
12
92
1.31
0.32
3.7
3.3
18.6
61.1
u/ml
1.44
12
92
11
84
1.31
0.30
1.7
1.2
—
—
—
0
0
11
84
1.31
0.30
1.7
1.2
—
—
—
0
0
11
84
1.31
0.30
1.7
1.2
—
—
—
0
0
7
57
1.23
0.29
1.1
1.5
0.9
1.0
g/l
—
7
57
47
422
1.12
0.28
1.5
1.4
—
—
—
0
0
33
375
0.88
0.28
1.4
1.5
—
—
—
0
0
9
74
1.22
0.25
1.1
1.1
1.4
1.4
g/l
—
9
68
35
313
1.12
0.23
2.7
3.6
2.3
1.7
mmol/l
0.45
26
233
5
38
1.32
0.23
1.4
1.4
—
—
—
0
0
10
79
1.27
0.22
1.4
1.6
—
—
—
0
0
60
556
1.08
0.21
1.5
1.5
—
—
—
0
0
5
42
1.19
0.21
1.8
1.3
—
—
—
0
0
5
42
1.19
0.21
1.8
1.3
—
—
—
0
0
5
42
1.19
0.21
1.8
1.3
—
—
—
0
0
33
296
1.12
0.21
2.3
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
7
58
1.21
0.18
1.3
1.4
—
—
—
0
0
24
215
1.12
0.16
1.7
1.2
—
—
—
0
0
9
83
1.09
0.14
1.9
1.2
—
—
—
0
0
80
837
0.95
0.14
4.6
3.9
34.2
33.5
%
0.24
58
568
10
84
1.19
0.14
1.8
1.2
—
—
—
0
0
10
84
1.19
0.14
1.8
1.2
—
—
—
0
0
13
113
1.15
0.13
1.6
1.3
—
—
—
0
0
11
127
0.86
0.12
2.5
2.0
13.5
13.1
%
0.40
11
127
41
435
0.94
0.11
1.6
1.7
—
—
—
0
0
11
126
0.87
0.11
1.6
1.5
—
—
—
0
0
12
135
0.89
0.10
1.2
1.7
6.5
7.3
mmol/l
—
7
81
25
233
1.08
0.09
1.1
1.2
—
—
—
0
0
40
380
1.06
0.09
2.4
1.7
3.9
4.2
mg/l
0.07
29
261
7
66
1.06
0.08
1.0
1.1
—
—
—
0
0
8
77
1.04
0.07
1.1
1.2
—
—
—
0
0
61
624
0.98
0.04
1.5
1.4
—
—
—
0
0
98
967
1.02
0.03
1.4
1.5
—
—
—
0
0
12
128
0.94
0.02
3.3
2.5
7.5
7.4
mmol/l
0.07
12
128
13
136
0.96
0.00
3.2
2.4
1.3
1.5
mmol/l
0.43
13
136
15
153
0.98
0.00
1.7
1.6
—
—
—
0
0
47
465
1.01
0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
20.3
—
0
5
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
86.6
—
0
5
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
8
83
0.96
0.00
1.3
1.3
49.2
33.0
nmol/l
—
8
73
0
5
0.00
0.00
0.0
1.0
—
7.8
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
9
89
1.01
0.00
3.1
1.9
3.6
55.7
u/ml
—
9
76
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
8.0
—
0
5
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
34.5
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint N14_ULCERVAGVUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ULCERVAGVUL | 1.353 [1.16, 1.58] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 484 out of 4215 females with N14_ULCERVAGVUL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_ULCERVAGVUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | No data |
| 5 | 0.701% | No data |
| 10 | 1.616% | No data |
| 15 | 3.088% | No data |
| 20 | 5.684% | No data |
Relationships between endpoints
↥Index endpoint: N14_ULCERVAGVUL – Ulcer of vagina/vulva
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data