Risteys · Q17_CONGEN_DEFORMITI

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Q66 Cause of death: ICD-10 — Q66 2 out of 7 registries used, show all original rules.	976
4. Check minimum number of events None	976
5. Include endpoints None	976
6. Filter based on genotype QC (FinnGen only)	976

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	12688	5897	6770
Only index persons	10876	5130	5746
Unadjusted period prevalence (%)
Whole population	0.18	0.17	0.19
Only index persons	0.20	0.19	0.22
Median age at first event (years)
Whole population	10.23	12.31	8.35
Only index persons	12.68	14.50	11.06

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	976	606	370
Unadjusted period prevalence (%)	0.19	0.21	0.16
Median age at first event (years)	36.82	38.46	34.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
870: Matched controls
8700

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Q66.7

ICD-10 Finland

Pes cavus

3428.5

285.6

260

Q66.0

ICD-10 Finland

Talipes equinovarus

2797.3

215.9

200

Q66.5

ICD-10 Finland

Congenital pes planus

321.0

160.4

158

Q66.8

ICD-10 Finland

Other congenital deformities of feet

+∞

117.4

110

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

7.7

79.2

201

326

Q66.9

ICD-10 Finland

Congenital deformity of feet, unspecified

277.1

75.7

Q66.2

ICD-10 Finland

Metatarsus varus

+∞

72.9

NHK40

NOMESCO Finland

Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone

28.0

67.6

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

6.3

49.0

140

257

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

7.8

48.8

118

171

Q66.4

ICD-10 Finland

Talipes calcaneovalgus

+∞

47.3

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

9.7

45.6

110

7545B

ICD-9 Finland

Certain congenital musculoskeletal deformities, Varus deformities of feet[TALIPES EQUINOVARUS CONGENITUS]

+∞

45.2

NHL68

NOMESCO Finland

Tenodesis, shortening or lengthening of tendon of foot

23.7

44.7

NHL14

NOMESCO Finland

Shortening or lengthening of achilles tendon

29.6

39.5

NHK30

NOMESCO Finland

Osteotomy or rotation osteotomy of first metatarsal or tarsal bone

8.9

37.8

102

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

9.2

36.4

Q66.6

ICD-10 Finland

Other congenital valgus deformities of feet

361.0

35.2

NHG22

NOMESCO Finland

Fusion of subtalar joint

30.3

34.6

75400

ICD-8 Finland

Clubfoot (congenital), Pes equino-varus adductus

93.8

33.0

NHG24

NOMESCO Finland

Fusion of subtalar joint and between bones of ankle

55.1

31.5

M21.5

ICD-10 Finland

Acquired clawhand, clubhand, clawfoot and clubfoot

165.8

30.9

TNH36

NOMESCO Finland

Custom molded cast of pes equinovarus

+∞

30.4

9341

FHL

Reduction and plaster or plaster exchange

+∞

30.4

M20.1

ICD-10 Finland

Hallux valgus (acquired)

4.6

30.1

110

263

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

13.8

29.5

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

7.1

28.7

109

M20.4

ICD-10 Finland

Other hammer toe(s) (acquired)

7.6

28.1

NHL99

NOMESCO Finland

Other operation on muscle or tendon of ankle or foot

19.9

26.7

TNX92

NOMESCO Finland

Supporting bandage or orthosis of lower limb

11.5

26.6

NH1AD

NOMESCO Finland

Ankle and foot CT

9.9

26.6

Q66.3

ICD-10 Finland

Other congenital varus deformities of feet

+∞

26.2

NH3FA

NOMESCO Finland

Weight-bearing X-ray of foot

11.5

26.1

TNH33

NOMESCO Finland

Custom moulded brace, ankle or foot

13.2

24.6

9343

FHL

Posterior release or posteromedical release

+∞

24.1

NH1BG

NOMESCO Finland

Ankle and foot MRI examination with high intensity magnet

8.4

23.8

L17

ICPC

Foot/toe symptom/complaint

2.3

22.6

265

1399

M19.0

ICD-10 Finland

Primary arthrosis of other joints

3.9

22.5

280

ZXE10

NOMESCO Finland

More than one and less than three hours

2.1

22.0

317

1835

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.9

21.3

144

558

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

5.8

21.2

111

NHT62

NOMESCO Finland

Surgical procedure for correction of pes equinovarus

+∞

20.9

SPAT1229

SPAT

Assessment of need for aid

4.5

20.9

185

NH1EA

NOMESCO Finland

Ankle X-ray examination with load or wrench

26.2

20.5

ZXA00

NOMESCO Finland

Right side

2.3

20.4

223

1127

B01AB05

ATC

enoxaparin; parenteral

2.3

20.4

227

1159

M79.6

ICD-10 Finland

Pain in limb

2.1

20.2

320

1911

M19.2

ICD-10 Finland

Other secondary arthrosis

11.7

20.1

L16

ICPC

Ankle symptom/complaint

2.8

20.1

144

578

TNX50

NOMESCO Finland

Removal of cutom molded cast and internal stretch

4.3

19.4

184

WX320

NOMESCO Finland

Spinalanesthesy

2.4

19.1

184

873

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.2

18.5

237

1285

NHG26

NOMESCO Finland

Fusion between bones of ankle or ankle and foot

13.9

18.3

NHL20

NOMESCO Finland

Myotomy or tenotomy of foot

25.7

18.3

NH1CG

NOMESCO Finland

Ankle and foot extensive MRI examination with high intensity magnet

8.3

18.2

NH3EA

NOMESCO Finland

Feet X-ray examination with load

8.3

18.2

TQW40

NOMESCO Finland

Remowal of suture of skin

3.6

17.9

245

L84

ICD-10 Finland

Corns and callosities

6.0

17.8

ZXA05

NOMESCO Finland

Left side

2.2

17.5

197

1003

NHG80

NOMESCO Finland

Fusion of first tarsometatarsal joint

6.1

17.5

NH1FA

NOMESCO Finland

Weight-bearing X-ray of ankle

14.2

17.4

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

4.3

17.1

161

N02BE01

ATC

paracetamol; systemic, rectal

2.0

17.1

689

5670

Q66.1

ICD-10 Finland

Talipes calcaneovarus

173.1

16.5

N02AX02

ATC

tramadol; systemic, rectal

1.9

16.0

306

1923

G60.0

ICD-10 Finland

Hereditary motor and sensory neuropathy

34.1

15.8

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.8

15.6

360

2413

M77.4

ICD-10 Finland

Metatarsalgia

3.5

15.0

219

N03AX16

ATC

pregabalin; oral

2.2

14.9

180

940

NHG20

NOMESCO Finland

Fusion of talocrural joint

21.5

14.7

R4110

NOMESCO Finland

Physiotherapy

2.0

14.4

221

1271

ICD-10 Finland

7.2

14.2

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.7

14.2

102

409

M19.1

ICD-10 Finland

Post-traumatic arthrosis of other joints

6.7

14.0

N02AJ06

ATC

codeine and paracetamol; systemic

1.8

13.8

310

2038

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.7

13.8

100

403

M25.5

ICD-10 Finland

Pain in joint

1.9

13.7

252

1545

L82

ICPC

Congenital anomaly musculoskeletal

76.3

13.6

M21.6

ICD-10 Finland

Other acquired deformities of ankle and foot

26.2

13.4

TNH31

NOMESCO Finland

Prefabricated orthosis, ankle or foot

7.4

13.3

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

3.4

13.3

201

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.9

12.9

293

NHL30

NOMESCO Finland

Suture or reinsertion of tendon of foot

14.3

12.8

Z50.1

ICD-10 Finland

Other physical therapy

3.7

12.7

160

NHK10

NOMESCO Finland

Incision or excision of metatarsal or tarsal bone

11.2

12.6

N03AX12

ATC

gabapentin; oral

2.3

12.5

119

554

Z31.5

ICD-10 Finland

Genetic counselling

3.1

12.1

231

SPAT1225

SPAT

Implementation of podiatry rehabilitation plan

5.9

11.7

S18

ICPC

Laceration/cut

1.7

11.7

309

2112

NH1AI

NOMESCO Finland

Cone beam CT of ankle

30.5

11.7

NHG77

NOMESCO Finland

Arthroplasty of interphalangeal tarsal joint(s)

5.6

11.3

Z3226

NOMESCO Finland

Physiotherapist

2.0

11.0

161

900

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

5.5

10.8

ZXE20

NOMESCO Finland

More than three and less than five hours

2.3

10.7

107

508

TNH32

NOMESCO Finland

Custom moulded split, ankle or foot

13.1

10.7

NHT99

NOMESCO Finland

Other operation on ankle or foot

60.7

10.6

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

3.6

10.6

136

TNX34

NOMESCO Finland

Major custom molded cast, unspecified region

6.3

10.5

M20.5

ICD-10 Finland

Other deformities of toe(s) (acquired)

12.2

10.4

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

3.5

10.3

139

NHG82

NOMESCO Finland

Fusion of other tarsal joint

9.7

10.3

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

2.3

10.1

419

9111

FHL

Plastering under anesthesia

16.9

9.9

NGL66

NOMESCO Finland

Transposition of tendon of knee or lower leg

26.3

9.8

Q87.88

ICD-10 Finland

Other specified congenital malformation syndromes, not elsewhere classified

26.3

9.8

NGK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of knee or lower leg

20.3

9.8

NHM10

NOMESCO Finland

Fasciotomy of ankle or foot

13.6

9.7

NH3BG

NOMESCO Finland

MRI of foot

10.2

9.5

TNX99

NOMESCO Finland

Other orthopaedic minor procedure

4.1

9.5

S83.0

ICD-10 Finland

Dislocation of patella

4.1

9.4

J01FF01

ATC

clindamycin; systemic

1.7

9.4

203

1289

7545A

ICD-9 Finland

Certain congenital musculoskeletal deformities, Varus deformities of feet[TALIPES VARUS CONGENITUS]

+∞

9.4

M01AH05

ATC

etoricoxib; oral

1.6

9.4

427

3314

L28

ICPC

Limited function/disability (L)

2.2

9.4

474

ZXD10

NOMESCO Finland

Scheduled procedure

1.6

9.1

295

2101

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

2.6

9.1

254

M17.1

ICD-10 Finland

Other primary gonarthrosis

2.1

9.0

111

579

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.3

9.0

388

NHK68

NOMESCO Finland

Shortening or lengthening osteotomy of ankle or foot

18.8

8.9

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

4.9

8.9

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.3

8.9

357

M01AC06

ATC

meloxicam; systemic, rectal

1.7

8.8

235

1586

M76.7

ICD-10 Finland

Peroneal tendinitis

8.7

8.8

NH2AA

NOMESCO Finland

Heel X-ray examination

10.8

8.8

AA1AD

NOMESCO Finland

CT of head and brain

1.9

8.7

138

791

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.6

8.6

293

2104

TNX32

NOMESCO Finland

Custom moulded splint, unspecified region

2.8

8.6

200

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.7

8.6

182

1148

WX213

NOMESCO Finland

Lower leg blockade

10.2

8.5

NFK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of femur

20.2

8.5

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

4.8

8.5

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.0

8.5

103

535

Z3229

NOMESCO Finland

Other healthcare associate professional

2.3

8.4

352

Q65.0

ICD-10 Finland

Congenital dislocation of hip, unilateral

+∞

8.3

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

5.6

8.3

M01AE03

ATC

ketoprofen; systemic, rectal

1.6

8.3

235

1611

S93.4

ICD-10 Finland

Sprain and strain of ankle

1.9

8.2

120

667

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.7

8.2

186

1198

ZXA10

NOMESCO Finland

Bilateral

1.9

8.1

132

763

9344

FHL

Other operation on soft tissue of the foot

33.7

8.1

M02AA07

ATC

piroxicam; topical

1.6

8.0

215

1448

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

6.4

8.0

NHG70

NOMESCO Finland

Arthroplasty of first tarsometatarsal joint

6.2

7.9

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.5

7.8

239

UJF32

NOMESCO Finland

Coloscopy

1.7

7.8

157

972

R4180

NOMESCO Finland

Podiatric therapy

7.0

7.8

NHH99

NOMESCO Finland

Other operation on joint of ankle or foot, unspecified

45.4

7.7

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

4.0

7.6

NH1CM

NOMESCO Finland

Ankle and foot extensive MRI examination with 3 Tesla magnet

25.2

7.6

M03BX02

ATC

tizanidine; oral

1.5

7.5

450

3641

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.3

7.5

291

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.5

7.4

226

9345

FHL

Tendon or tendon transplantation

80.7

7.4

NGU10

NOMESCO Finland

Removal of external fixation device from knee or lower leg

80.7

7.4

Z3231

NOMESCO Finland

Registered nurse

1.6

7.4

215

1477

NHU10

NOMESCO Finland

Removal of external fixation device from ankle or foot

8.5

7.3

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.6

7.3

194

1298

N06AX21

ATC

duloxetine; oral

2.0

7.3

454

M03BC01

ATC

orphenadrine (citrate); systemic

1.7

7.3

181

1191

Q65.1

ICD-10 Finland

Congenital dislocation of hip, bilateral

+∞

7.3

J01DB01

ATC

cefalexin; oral

1.6

7.2

670

5939

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.2

7.2

358

SPAT1210

SPAT

Application of cast or individual aid

2.9

7.2

151

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.7

7.1

154

972

L04AA01

ATC

[U] ciclosporin; systemic

5.4

7.1

A02BC01

ATC

omeprazole; systemic

1.7

7.1

174

1139

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.7

7.0

145

906

ZXE00

NOMESCO Finland

One hour or less

1.5

6.9

303

2284

M01AH01

ATC

celecoxib; oral (coxibs)

1.9

6.9

108

616

A02BC05

ATC

esomeprazole; systemic

1.5

6.9

258

1880

Z01.0

ICD-10 Finland

Examination of eyes and vision

1.8

6.7

127

770

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.5

6.7

361

2834

R03AC02

ATC

salbutamol; inhalant

1.5

6.7

421

3415

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.8

6.7

106

607

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

4.3

6.6

SPAT1216

SPAT

Assessment of functional ability

2.0

6.6

465

M22.0

ICD-10 Finland

Recurrent dislocation of patella

4.8

6.6

J01AA02

ATC

doxycycline; systemic

1.5

6.6

534

4547

SHB00

NOMESCO Finland

Prepation and fitting of bite rail to mouth

1.9

6.5

537

XKC03

NOMESCO Finland

Water cystometry

3.7

6.5

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

6.2

6.5

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.7

6.4

143

908

NH1BM

NOMESCO Finland

Ankle and foot MRI examination with 3 Tesla magnet

70.3

6.4

A03FA02

ATC

cisapride; oral, rectal

2.4

6.4

217

SPAT1301

SPAT

No procedures

1.5

6.4

243

1771

TNX39

NOMESCO Finland

Other orthopedic bandage, unspecified region

5.0

6.4

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.6

6.4

169

1128

M70.6

ICD-10 Finland

Trochanteric bursitis

2.0

6.3

372

G04BD07

ATC

tolterodine; oral

3.3

6.3

NF1BA

NOMESCO Finland

Hip extensive X-ray examination

4.6

6.3

NK4EA

NOMESCO Finland

Joint X-ray examintion with load or wrench not elsewhere classified

11.1

6.3

R52.9

ICD-10 Finland

Pain, unspecified

2.1

6.3

337

M21.1

ICD-10 Finland

Varus deformity, not elsewhere classified

18.2

6.3

M21.0

ICD-10 Finland

Valgus deformity, not elsewhere classified

18.2

6.3

M66.4

ICD-10 Finland

Spontaneous rupture of other tendons

18.2

6.3

Q74.3

ICD-10 Finland

Arthrogryposis multiplex congenita

+∞

6.3

L89

ICD-10 Finland

Decubitus ulcer and pressure area

7.1

6.2

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

4.2

6.2

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.4

6.2

224

M67.0

ICD-10 Finland

Short Achilles tendon (acquired)

6.3

6.2

ZA7.0

ICD-10 Finland

Ankle and foot

5.8

6.2

J01DA01

ATC

[U] cefalexin; systemic

1.4

6.2

475

3979

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

3.3

6.2

H02AB04

ATC

methylprednisolone; systemic

1.8

6.2

541

M01AB05

ATC

diclofenac; systemic, rectal

1.4

6.0

456

3797

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

2.7

6.0

139

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_CONGEN_DEFORMITI_FEET and mortality.

Females

Parameter	HR [95% CI]	p-value
Q17_CONGEN_DEFORMITI_FEET	1.245 [1.01, 1.53]	0.039
Birth year	0.997 [0.99, 1.01]	0.516

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 5121 females with Q17_CONGEN_DEFORMITI_FEET died.

Males

Parameter	HR [95% CI]	p-value
Q17_CONGEN_DEFORMITI_FEET	1.2 [0.98, 1.48]	0.085
Birth year	0.987 [0.98, 1.0]	0.006

During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 5999 males with Q17_CONGEN_DEFORMITI_FEET died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_DEFORMITI_FEET.

N-year risk	Females	Males
1	0.132%	0.187%
5	0.679%	1.352%
10	1.731%	3.274%
15	3.539%	6.665%
20	6.656%	10.99%

Relationships between endpoints

↥

Index endpoint: Q17_CONGEN_DEFORMITI_FEET – Congenital deformities of feet

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

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NAME	Q17_CONGEN_DEFORMITI_FEET
CONTROL_EXCLUDE	Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Q66
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Q66
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Congenital deformities of feet

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints