Viral conjunctivitis

AB1_VIRAAL_CONJUNCT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B30
  • Hospital discharge: ICD-9 07[7]
  • Hospital discharge: ICD-8 07[8]
  • Cause of death: ICD-10 B30
  • Cause of death: ICD-9 07[7]
  • Cause of death: ICD-8 07[8]

2 out of 7 registries used, show all original rules.

832

4. Check minimum number of events

None

832

5. Include endpoints

None

832

6. Filter based on genotype QC (FinnGen only)

797

Control definitions (FinnGen only)

Control exclude
AB1_OTHER_VIRAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6693 3672 2988
Only index persons 6103 3418 2685
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.08
Only index persons 0.12 0.13 0.10
Median age at first event (years)
Whole population 32.92 35.43 29.78
Only index persons 34.62 36.51 32.22

-FinnGen-

Key figures

All Female Male
Number of individuals 797 529 268
Unadjusted period prevalence (%) 0.17 0.19 0.12
Median age at first event (years) 42.68 41.64 44.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
832
Matched controls
8320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H13.1*B30.1
ICD-10 Finland
Conjunctivitis due to adenovirus
+∞
268.8
243
*
H19.2*B30.0
ICD-10 Finland
Epidemic keratoconjunctivitis
+∞
234.8
214
*
B30.9
ICD-10 Finland
Viral conjunctivitis, unspecified
316.8
157.4
155
6
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
7.3
104.5
175
293
B30.1
ICD-10 Finland
Conjunctivitis due to adenovirus
833.4
78.7
76
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.8
77.4
481
2222
S01AD03
ATC
aciclovir; ophthalmic
8.9
68.3
89
110
B30.0
ICD-10 Finland
Keratoconjunctivitis due to adenovirus
+∞
65.5
62
*
H16.9
ICD-10 Finland
Keratitis, unspecified
10.7
53.7
60
60
H13.1*B30.8
ICD-10 Finland
Other viral conjunctivitis
+∞
48.4
46
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
18.1
46.5
38
22
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.4
43.4
120
306
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.7
38.6
315
1546
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
3.7
29.3
102
305
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
27.4
139
523
H10
ICD-10 Finland
Conjunctivitis
3.3
26.9
109
359
Z2221
NOMESCO Finland
Medical doctor
2.3
26.5
283
1524
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
8.6
23.3
30
36
F03
ICPC
Eye discharge
3.3
23.2
93
303
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.1
19.8
56
144
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
19.5
224
1219
H01.0
ICD-10 Finland
Blepharitis
3.1
19.0
84
290
F29
ICPC
Eye symptom/complaint other
2.7
17.4
104
423
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
17.2
168
853
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
16.9
320
2060
H57.1
ICD-10 Finland
Ocular pain
3.6
16.8
56
162
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.7
16.4
95
380
H10.2
ICD-10 Finland
Other acute conjunctivitis
6.1
16.1
28
47
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
14.1
15.6
26
19
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
4.1
15.2
42
106
0779X
ICD-9 Finland
Other diseases of conjunctiva due to viruses and Chlamydiae, Unspecified diseases of conjunctiva due to viruses and Chlamydiae
+∞
14.6
14
*
Z3231
NOMESCO Finland
Registered nurse
1.9
13.3
230
1418
F02
ICPC
Red eye
3.3
13.2
52
167
H15.1
ICD-10 Finland
Episcleritis
5.7
12.9
24
43
H10.5
ICD-10 Finland
Blepharoconjunctivitis
4.6
12.9
31
70
H02AB06
ATC
prednisolone; systemic
1.7
12.9
374
2679
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.5
12.6
43
126
B30.8
ICD-10 Finland
Other viral conjunctivitis
+∞
12.5
12
*
ZXA05
NOMESCO Finland
Left side
1.9
12.3
179
1041
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
12.1
118
595
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.2
11.7
46
148
Z71.8
ICD-10 Finland
Other specified counselling
1.7
11.7
278
1873
Z3226
NOMESCO Finland
Physiotherapist
2.0
11.6
154
867
R4110
NOMESCO Finland
Physiotherapy
1.8
11.4
219
1386
F01
ICPC
Eye pain
3.5
11.4
39
115
S01AA01
ATC
chloramphenicol; ophthalmic
3.1
11.3
49
167
R03AC03
ATC
terbutaline; inhalant
2.0
10.9
124
661
H19.2
ICD-10 Finland
Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
60.8
10.6
12
*
ZXA00
NOMESCO Finland
Right side
1.8
10.5
190
1178
ZXE00
NOMESCO Finland
One hour or less
1.6
10.3
317
2268
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
10.3
308
2189
S01ED51
ATC
timolol, combinations; ophthalmic
2.8
9.9
51
192
D06
ICPC
Abdominal pain localized other
2.3
9.9
80
373
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.5
144
844
R06AX27
ATC
desloratadine; oral
1.6
9.5
269
1880
S01XA18
ATC
ciclosporin; ophthalmic
10.8
9.3
17
16
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
9.3
89
444
WW200
NOMESCO Finland
Immunization
3.6
9.3
30
85
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
9.3
115
631
J01AA02
ATC
doxycycline; systemic
1.6
9.2
603
5117
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
9.2
271
1908
S01BA01
ATC
dexamethasone; ophthalmic
3.2
9.1
35
111
A02BC02
ATC
pantoprazole; systemic
1.6
9.0
506
4130
XCH00
NOMESCO Finland
Eye pressure measurement
3.0
8.9
38
129
S01ED01
ATC
timolol; ophthalmic
4.1
8.8
24
60
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
8.7
165
1032
R4120
NOMESCO Finland
Occupational therapy
2.4
8.6
61
269
XCK00
NOMESCO Finland
Perimetry
2.7
8.6
47
183
D11
ICPC
Diarrhoea
1.9
8.4
118
673
J05AB11
ATC
valaciclovir; oral
1.9
8.4
124
719
R03DC03
ATC
montelukast; oral
1.8
8.4
146
890
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
8.4
69
324
J01DA01
ATC
[U] cefalexin
1.5
8.2
491
4024
J01DB01
ATC
cefalexin; oral
1.7
8.2
678
5994
F73
ICPC
Eye infection/inflammation other
3.6
8.2
26
73
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
8.1
112
636
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.1
8.1
22
55
Z3229
NOMESCO Finland
Other healthcare associate professional
2.3
8.1
64
296
L04AA06
ATC
mycophenolic acid; systemic
4.5
7.9
19
43
J05AB01
ATC
aciclovir; systemic
1.7
7.9
184
1214
S01BA04
ATC
prednisolone; ophthalmic
4.0
7.9
22
56
R03AC02
ATC
salbutamol; inhalant
1.5
7.8
453
3673
S01BC03
ATC
diclofenac; ophthalmic
4.2
7.8
20
48
S01GX05
ATC
lodoxamide; ophthalmic
4.6
7.7
18
40
ZXA10
NOMESCO Finland
Bilateral
1.8
7.5
130
792
H10.4
ICD-10 Finland
Chronic conjunctivitis
6.9
7.3
17
25
H13.1*A74.0
ICD-10 Finland
Chlamydial conjunctivitis
+∞
7.3
7
*
B27.0
ICD-10 Finland
Gammaherpesviral mononucleosis
+∞
7.3
7
*
G44.2
ICD-10 Finland
Tension-type headache
1.8
7.3
121
727
B07.9
ICD-10 Finland
Verruca simplex
2.8
7.2
35
128
H20.8
ICD-10 Finland
Other iridocyclitis
10.1
7.0
13
13
M01AH05
ATC
etoricoxib; oral
1.5
7.0
496
4147
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.9
108
636
J01FF01
ATC
clindamycin; systemic
1.6
6.9
207
1449
S01EE05
ATC
tafluprost; ophthalmic
3.3
6.9
25
77
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
9.4
6.8
13
14
H02AB07
ATC
prednisone; oral
1.8
6.8
98
564
114
Kela drug reimbursment
Glaucoma
2.4
6.8
46
199
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
6.7
169
1136
S01EA05
ATC
brimonidine; ophthalmic
4.2
6.6
17
41
L15
ICPC
Knee symptom/complaint
1.6
6.5
177
1208
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
6.5
142
919
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.5
146
953
R06AE07
ATC
cetirizine; oral
1.5
6.5
360
2858
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
70.4
6.4
7
*
L17
ICPC
Foot/toe symptom/complaint
1.5
6.4
217
1557
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.4
148
972
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
6.4
63
319
XF600
NOMESCO Finland
Bloodpressure measurement
2.3
6.3
48
218
TAB00
NOMESCO Finland
Lumbar puncture
2.3
6.3
46
206
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.9
6.3
18
47
J02AC01
ATC
fluconazole; systemic
1.5
6.3
323
2522
H53.1
ICD-10 Finland
Subjective visual disturbances
2.2
6.3
54
259
07810
ICD-8 Finland
Other viral diseases of the conjunctiva, Epidemic keratoconjunctivitis
+∞
6.3
6
*
B30.2
ICD-10 Finland
Viral pharyngoconjunctivitis
+∞
6.3
6
*
Z2446
NOMESCO Finland
Social worker
2.1
6.2
59
294
R2110
NOMESCO Finland
Giving the first information
2.1
6.1
58
289
R01AD09
ATC
mometasone; nasal
1.4
6.1
377
3044
A01
ICPC
Pain general/multiple sites
1.9
6.1
71
382
CG2S4
NOMESCO Finland
Photography of cornea
10.1
6.0
11
11
XQ800
NOMESCO Finland
Prick test
1.9
6.0
70
375
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.0
434
3599
H02AB04
ATC
methylprednisolone; systemic
1.7
6.0
103
624

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
64
24
28.81
94.28
1.1
1.2
—
—
—
0
0
182
730
2.91
32.28
1.9
1.5
—
—
—
0
0
277
1669
1.99
18.06
7.6
6.4
—
—
—
0
0
179
931
2.18
17.26
3.3
2.7
3.21
2.97
e6/l
0.11
94
491
185
982
2.14
16.90
3.2
2.6
0.70
0.96
e6/l
0.86
99
543
414
3006
1.75
13.90
9.7
8.7
0.00
0.01
e9/l
0.49
316
2478
249
1567
1.84
13.54
4.2
3.6
93.86
94.45
%
0.14
243
1519
413
3046
1.71
12.71
8.8
5.9
0.71
0.68
%
0.47
390
2864
255
1643
1.80
12.70
3.9
2.8
0.24
0.38
e6/l
0.91
190
1228
274
1809
1.77
12.53
4.0
2.9
21.20
66.63
e6/l
2.61
208
1372
21
16
13.43
12.48
1.2
1.3
—
—
—
0
0
594
4876
1.76
12.02
4.3
3.8
10.88
10.33
mm/h
0.51
564
4541
424
3186
1.67
11.88
8.8
6.0
8.28
8.24
%
0.11
402
3010
422
3171
1.67
11.79
8.7
5.7
3.01
2.81
%
1.05
401
2988
441
3361
1.66
11.59
8.6
5.7
0.56
0.55
e9/l
0.35
382
2953
441
3368
1.66
11.44
8.6
5.7
0.04
0.04
e9/l
0.30
382
2961
433
3308
1.64
11.09
8.7
5.8
29.61
29.02
%
0.55
415
3132
428
3269
1.64
10.90
8.3
5.6
55.89
56.55
%
0.62
409
3090
417
3176
1.63
10.66
8.6
6.2
—
—
—
0
0
449
3488
1.62
10.54
9.0
6.1
0.19
0.19
e9/l
0.40
402
3094
449
3490
1.62
10.50
8.6
5.7
1.95
1.95
e9/l
0.00
403
3134
310
2202
1.65
10.42
4.9
3.3
31.13
100.68
e6/l
2.18
216
1485
165
990
1.83
10.14
1.4
1.3
324.14
516.45
titre
1.12
29
203
243
1632
1.69
10.07
4.0
2.8
—
—
—
0
0
187
1174
1.76
9.85
3.5
2.6
546.75
544.35
mosm/kgh2o
0.04
162
1015
191
1217
1.74
9.52
1.3
1.3
11.02
13.11
u/ml
0.16
73
514
487
3914
1.59
9.49
11.2
8.8
3.79
4.01
e9/l
1.77
426
3431
195
1251
1.73
9.48
1.4
1.3
16.77
30.86
iu/ml
1.77
55
423
246
1694
1.64
9.11
5.7
3.6
7.40
7.40
ph
0.13
28
316
152
924
1.79
8.87
2.6
2.4
114.85
119.15
ug/g
0.08
122
735
228
1559
1.64
8.62
2.6
2.3
4189.02
5582.04
umol/l
0.23
201
1392
695
6163
1.78
8.60
18.3
13.9
13.87
14.39
%
2.89
687
6073
375
2883
1.55
8.56
7.9
6.2
1.21
1.22
mmol/l
0.62
342
2478
108
600
1.92
8.36
2.9
2.3
31.89
35.68
u/l
0.51
99
516
215
1463
1.63
8.23
3.4
3.2
—
—
—
0
0
43
164
2.71
8.16
2.3
3.2
—
—
—
0
0
141
861
1.77
8.06
2.0
2.0
—
—
—
0
0
18
40
4.58
7.68
1.3
1.3
—
—
—
0
0
215
1490
1.60
7.56
1.5
1.4
2.14
2.28
g/l
0.68
128
939
336
2575
1.51
7.50
7.4
5.7
1.21
1.22
mmol/l
1.29
315
2368
91
501
1.92
7.23
2.4
2.3
34.88
26.40
au/ml
—
5
45
752
6912
1.91
7.17
15.2
11.4
19.85
21.35
mg/l
0.67
599
5311
536
4569
1.49
6.77
4.9
3.8
—
—
—
0
0
82
453
1.90
6.45
8.4
8.8
—
—
—
0
0
110
668
1.75
6.37
6.7
7.3
104.50
104.22
mmol/l
0.30
110
668
178
1231
1.57
6.19
3.1
2.3
4.59
6.83
e6/l
1.58
159
1111
39
164
2.45
6.13
1.4
1.2
—
—
—
0
0
567
4932
1.47
6.12
8.4
6.8
76.68
76.56
u/l
0.03
545
4660
87
499
1.83
6.10
5.6
4.0
1.45
1.87
mmol/l
0.52
79
415
317
2492
1.44
5.84
5.4
4.6
36.94
36.47
g/l
0.87
302
2337
118
749
1.67
5.81
1.7
1.4
—
—
—
0
0
64
339
1.96
5.71
1.1
1.1
—
—
—
0
0
698
6372
1.59
5.69
5.1
4.6
3.60
2.01
mu/l
0.42
662
5951
113
727
1.64
5.27
3.2
2.5
5.43
6.95
umol/l
0.83
102
619
84
503
1.75
5.11
3.4
2.7
11.34
10.27
g/l
1.36
77
456
19
60
3.22
5.06
1.3
1.2
—
—
—
0
0
234
1783
1.43
4.96
2.4
1.9
—
—
—
0
0
511
4449
1.39
4.86
3.2
3.2
—
—
—
0
0
396
3311
1.37
4.83
5.2
4.4
0.00
0.00
estimate
0.50
55
662
226
1719
1.43
4.82
1.3
1.3
0.89
1.74
u/ml
1.34
52
485
21
73
2.93
4.79
1.8
2.2
—
—
—
0
0
778
7372
1.85
4.69
11.7
9.0
26.91
26.70
u/l
0.09
762
7161
91
573
1.66
4.62
1.2
1.2
—
—
—
0
0
735
6872
1.60
4.52
15.2
12.5
3.92
3.94
mmol/l
1.84
719
6682
733
6851
1.59
4.49
15.0
12.4
139.75
139.63
mmol/l
0.72
719
6677
287
2300
1.38
4.47
3.2
3.1
28.16
31.26
u/l
2.16
271
2197
148
1052
1.49
4.45
3.6
3.2
186.78
439.04
ng/l
0.95
99
698
35
163
2.20
4.43
1.4
1.8
2.96
12.20
e6/l
1.24
25
127
35
163
2.20
4.43
1.4
1.8
164.40
133.27
e6/l
0.09
25
132
422
3596
1.35
4.42
5.1
4.5
6.48
6.53
mmol/l
0.20
395
3315
51
274
1.92
4.42
4.4
3.1
—
—
—
0
0
396
3344
1.35
4.39
3.5
3.2
0.00
0.01
estimate
0.80
51
642
140
988
1.50
4.36
2.3
1.6
—
—
—
0
0
331
2726
1.36
4.30
2.1
2.0
—
—
—
0
0
14
34
4.17
4.22
3.1
2.6
699.93
515.41
u/ml
0.34
14
34
218
1692
1.39
4.06
1.7
1.6
1.39
1.40
mmol/l
0.06
192
1459
97
645
1.57
3.96
1.9
1.5
—
—
—
0
0
226
1772
1.38
3.95
2.8
2.6
—
—
—
0
0
388
3304
1.33
3.92
3.5
3.2
0.00
0.00
estimate
0.50
58
691
32
152
2.15
3.89
1.4
1.8
—
—
—
0
0
19
71
2.72
3.84
1.4
1.4
—
—
—
0
0
26
114
2.32
3.81
1.2
1.1
—
—
—
0
0
18
66
2.77
3.77
1.7
2.2
48.63
40.52
%
1.28
18
66
18
66
2.77
3.77
1.7
1.8
—
—
—
0
0
379
3230
1.32
3.75
5.7
5.7
9.98
10.90
umol/l
1.92
360
3053
191
1468
1.39
3.74
5.3
4.0
—
—
—
0
0
323
2703
1.32
3.61
3.4
3.0
6.11
5.82
ph
1.08
28
255
47
264
1.83
3.59
7.8
10.9
24.71
24.20
mmol/l
0.54
47
259
594
5415
1.34
3.52
4.4
3.9
14.40
14.51
pmol/l
0.62
559
5006
40
216
1.89
3.46
1.2
1.1
—
—
—
0
0
64
400
1.65
3.39
2.4
1.7
2.08
1.26
g/l
0.86
59
371
216
1719
1.35
3.37
2.0
2.0
141.37
231.24
u/l
1.51
211
1627
320
2694
1.31
3.37
2.7
2.3
74.63
74.58
nmol/l
0.01
289
2476
16
59
2.75
3.33
1.5
1.6
—
—
—
0
0
17
65
2.65
3.32
3.1
2.2
3.95
4.06
mmol/l
0.92
17
65
17
65
2.65
3.32
3.1
2.2
104.71
105.66
mmol/l
0.38
17
65
17
65
2.65
3.32
3.1
2.2
—
—
—
0
0
194
1528
1.35
3.23
1.9
1.7
0.87
1.00
mg/l
0.44
147
1162
10
24
4.20
3.20
1.2
1.3
—
—
—
0
0
34
179
1.94
3.19
1.3
1.6
403.76
462.29
mg/l
0.90
34
168
28
139
2.05
3.09
1.8
1.6
5200.95
16030.67
e6/l
1.42
19
101
810
7874
2.09
3.03
21.6
16.8
4.55
4.55
e12/l
0.01
787
7699
809
7863
2.04
2.99
21.7
16.9
40.67
41.16
%
0.36
781
7476
273
2283
1.29
2.94
2.0
1.8
99.28
97.67
pmol/l
0.22
139
1202
369
3216
1.26
2.82
3.1
2.7
111.34
96.36
ug/l
0.44
354
3013
21
97
2.20
2.79
1.6
1.5
—
—
—
0
0
63
413
1.57
2.78
5.8
3.8
100.69
76.63
ng/l
1.19
55
374
99
714
1.44
2.78
1.4
1.3
—
—
—
0
0
809
7876
1.98
2.76
21.6
16.8
6.65
6.63
e9/l
0.06
786
7691
5
6
8.37
2.75
1.2
1.0
—
—
—
0
0
11
34
3.26
2.73
1.2
1.4
—
—
—
0
0
7
14
5.03
2.73
1.3
1.1
—
—
—
0
0
27
139
1.97
2.73
1.9
1.4
—
—
—
0
0
222
1827
1.29
2.67
3.3
3.1
8.25
7.97
mmol/l
0.32
184
1579
55
353
1.60
2.67
1.1
1.1
—
—
—
0
0
12
41
2.95
2.62
2.1
2.0
—
—
—
0
0
180
1447
1.31
2.58
2.0
1.6
—
—
—
0
0
16
68
2.38
2.57
1.3
1.4
—
—
—
0
0
98
719
1.41
2.51
1.5
1.4
—
—
—
0
0
28
151
1.88
2.50
3.1
2.1
—
—
—
0
0
807
7866
1.86
2.49
21.7
16.8
253.22
257.50
e9/l
1.32
787
7702
42
257
1.67
2.47
1.3
1.2
—
—
—
0
0
763
7345
1.47
2.44
11.7
10.5
—
—
—
0
0
29
161
1.83
2.38
1.3
1.5
3.95
3.67
mmol/l
0.43
29
149
129
1000
1.34
2.37
3.2
2.6
2.44
2.43
mmol/l
0.14
109
880
22
112
1.99
2.32
1.5
1.6
—
—
—
0
0
22
113
1.97
2.27
1.1
1.2
—
—
—
0
0
112
856
1.36
2.26
2.0
1.8
—
—
—
0
0
79
570
1.43
2.24
6.9
8.9
1.05
1.02
mmol/l
0.03
66
455
18
86
2.12
2.24
1.1
1.3
—
53.97
—
0
7
5
9
5.58
2.21
1.0
1.1
—
—
—
0
0
11
41
2.71
2.21
1.4
1.4
5.36
7.85
u/l
0.75
11
36
50
330
1.55
2.19
2.6
2.1
—
—
—
0
0
36
220
1.67
2.15
6.4
9.3
—
—
—
0
0
6
14
4.31
2.15
1.0
1.0
4.54
5.95
mg/g
—
6
14
235
1995
1.25
2.15
3.4
3.2
2.35
2.35
mmol/l
0.10
212
1795
8
25
3.22
2.10
1.0
1.5
32.75
28.08
umol/l
—
8
25
530
4903
1.22
2.07
2.9
2.9
40.20
42.87
u/l
0.51
512
4659
6
15
4.02
2.04
1.0
1.1
0.02
0.40
u/ml
—
6
15
234
2007
1.23
1.93
2.9
2.1
—
—
—
0
0
24
136
1.79
1.89
6.1
3.8
—
—
—
0
0
181
1516
1.25
1.85
2.2
2.1
—
—
—
0
0
41
271
1.54
1.82
1.5
1.2
—
—
—
0
0
7
23
3.06
1.80
2.3
2.1
—
—
—
0
0
16
81
1.99
1.75
1.1
1.0
—
—
—
0
0
7
24
2.93
1.72
2.0
1.4
104.70
61.92
nmol/24h
—
7
24
108
857
1.30
1.72
1.2
1.2
—
—
—
0
0
36
537
0.66
1.71
5.2
3.6
—
—
—
0
0
82
626
1.34
1.71
2.5
1.9
352.07
368.86
nmol/l
0.38
73
576
152
1263
1.25
1.67
1.4
1.5
20.34
21.00
nmol/l
0.25
132
1094
16
83
1.95
1.65
1.3
1.3
—
—
—
0
0
30
189
1.61
1.65
1.1
1.2
—
660.00
—
0
6
57
413
1.41
1.63
1.3
1.2
—
—
—
0
0
37
246
1.53
1.63
1.6
1.4
—
—
—
0
0
40
271
1.50
1.62
2.5
2.2
—
—
—
0
0
5
14
3.59
1.61
1.2
1.2
—
—
—
0
0
19
106
1.81
1.60
2.2
2.0
—
1792.00
—
0
5
33
215
1.56
1.59
1.2
1.2
—
—
—
0
0
191
1635
1.22
1.59
4.2
3.8
10.92
10.50
mg/mmol
0.05
118
1036
6
20
3.01
1.58
1.7
2.6
—
—
—
0
0
182
1552
1.22
1.57
3.5
3.2
66.89
231.19
mg/l
1.21
119
1009
631
6007
1.21
1.56
5.4
4.8
38.46
38.80
mmol/mol
0.48
604
5667
21
122
1.74
1.55
1.1
1.1
7.36
6.02
u/ml
—
10
48
19
107
1.79
1.55
1.3
1.1
—
—
—
0
0
17
93
1.85
1.52
2.7
2.6
—
—
—
0
0
58
429
1.38
1.49
1.8
2.0
—
—
—
0
0
37
252
1.49
1.48
1.6
1.5
—
—
—
0
0
58
430
1.37
1.47
1.8
1.9
—
—
—
0
0
76
588
1.32
1.47
1.3
1.2
191.93
144.52
iu/ml
0.63
32
244
16
87
1.86
1.46
2.4
1.7
—
—
—
0
0
5
16
3.14
1.44
8.4
6.4
—
—
—
0
0
92
734
1.28
1.43
10.2
5.2
1.08
1.04
mmol/l
0.67
86
686
58
433
1.36
1.42
1.8
2.0
—
—
—
0
0
36
246
1.48
1.42
1.6
1.4
—
—
—
0
0
125
1036
1.24
1.42
1.8
1.7
—
—
—
0
0
94
754
1.28
1.40
3.3
2.3
23.39
23.45
%
0.01
88
648
121
1002
1.24
1.38
1.5
1.5
—
—
—
0
0
57
427
1.36
1.37
1.8
1.9
—
—
—
0
0
9
41
2.21
1.37
4.2
2.0
—
—
—
0
0
5
17
2.95
1.36
2.6
2.1
86.60
79.84
ug/l
—
5
17
708
6845
1.23
1.34
4.6
4.2
2.88
2.86
mmol/l
0.30
682
6429
10
47
2.14
1.34
1.2
1.1
—
—
—
0
0
63
482
1.33
1.33
2.5
2.1
15.27
12.85
nmol/l
1.38
51
448
20
121
1.67
1.31
3.1
4.8
—
—
—
0
0
8
35
2.30
1.27
1.1
1.1
—
—
—
0
0
19
115
1.67
1.25
1.3
1.1
—
—
—
0
0
6
25
2.41
1.24
3.2
3.9
—
—
—
0
0
63
488
1.31
1.24
1.3
1.3
25.09
26.75
iu/l
0.18
54
409
107
888
1.24
1.22
2.9
2.2
14.00
13.80
umol/l
0.10
102
826
674
6504
1.19
1.19
4.3
3.9
5.79
5.80
mmol/l
0.04
633
6030
337
3094
1.15
1.19
2.7
2.5
—
—
—
0
0
6
26
2.32
1.19
1.0
1.0
280.83
257.93
ng/l
—
6
15
242
2169
1.16
1.18
3.0
3.1
192.67
48.66
ng/l
0.96
130
1281
40
291
1.39
1.17
1.6
2.5
—
—
—
0
0
28
190
1.49
1.17
2.4
2.2
—
—
—
0
0
10
50
2.01
1.17
2.3
3.2
—
—
—
0
0
276
2503
1.15
1.15
10.9
10.0
1.12
1.16
inr
0.42
68
794
8
40
2.01
1.12
1.0
1.1
—
—
—
0
0
51
391
1.32
1.10
2.6
2.3
—
—
—
0
0
45
339
1.35
1.09
1.4
1.9
—
—
—
0
0
38
279
1.38
1.07
2.7
1.7
—
—
—
0
0
21
137
1.55
1.06
1.1
1.0
6.49
3.65
u/ml
—
10
64
98
819
1.22
1.06
3.1
2.2
2.33
2.39
g/l
0.46
91
762
18
113
1.61
1.06
1.2
1.1
—
—
—
0
0
7
34
2.07
1.03
1.0
1.1
1452.14
1698.88
miu/ml
—
7
34
37
273
1.37
1.02
8.6
12.0
—
—
—
0
0
63
504
1.27
1.01
2.7
4.4
2.70
31.17
ug/l
1.05
46
396
51
398
1.30
0.99
1.8
2.0
—
—
—
0
0
9
49
1.85
0.99
2.6
6.4
11.76
12.44
%
—
9
49
21
140
1.51
0.98
6.3
3.7
57.14
56.48
%
0.10
21
140
24
165
1.47
0.97
3.2
2.3
—
—
—
0
0
24
165
1.47
0.97
1.1
1.1
0.65
2.28
u/ml
1.46
12
87
10
54
1.86
0.97
3.1
2.5
1.05
1.77
g/24h
—
5
32
24
166
1.46
0.95
1.0
1.1
5.88
6.27
u/ml
0.04
14
91
22
150
1.48
0.93
1.5
1.2
155.62
248.00
u/ml
1.83
16
89
6
27
2.23
0.93
1.0
1.4
137.02
163.16
nmol/l
—
6
27
27
192
1.42
0.93
1.1
1.1
1.91
2.38
u/ml
0.09
14
102
695
6761
1.17
0.93
4.2
3.9
4.75
4.76
mmol/l
0.10
672
6390
20
135
1.49
0.89
2.2
1.8
—
—
—
0
0
35
263
1.35
0.89
1.8
1.6
—
—
—
0
0
16
103
1.56
0.88
3.3
3.7
—
—
—
0
0
23
161
1.44
0.87
1.0
1.1
1.37
1.33
u/ml
—
9
72
53
426
1.26
0.84
1.2
1.2
—
—
—
0
0
6
31
1.94
0.84
1.0
1.2
174.50
186.80
mmol/24h
—
6
31
168
1504
1.15
0.84
2.4
2.1
2.70
2.88
mg/l
0.49
148
1299
27
197
1.38
0.83
4.1
4.3
—
—
—
0
0
56
455
1.25
0.82
1.5
2.6
5.74
6.67
e9/l
0.18
48
397
12
73
1.65
0.82
3.0
1.6
17.50
21.64
nmol/l
0.95
12
68
12
73
1.65
0.82
1.0
1.3
—
—
nmol/l
—
0
0
6
32
1.88
0.82
2.2
2.5
8.18
11.21
mg/l
—
6
23
8
48
1.67
0.79
2.4
1.8
7.69
6.45
mmol/l
—
8
35
6
34
1.77
0.76
1.0
1.1
297.63
159.39
iu/ml
—
6
34
23
166
1.40
0.76
1.1
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
4.5
—
—
—
0
0
42
333
1.28
0.76
1.5
1.3
170.08
236.91
miu/ml
0.87
24
170
5
24
2.09
0.74
1.6
1.6
—
—
—
0
0
7
38
1.85
0.73
1.1
1.0
—
—
—
0
0
5
25
2.01
0.72
1.0
1.0
—
—
—
0
0
7
39
1.80
0.72
1.1
1.0
—
—
—
0
0
6
110
0.54
0.72
1.7
1.5
—
—
—
0
0
9
57
1.59
0.71
1.0
1.1
—
4.42
—
0
13
7
43
1.63
0.67
1.1
1.1
—
—
—
0
0
12
78
1.55
0.65
2.8
1.6
—
—
—
0
0
7
44
1.60
0.65
1.1
1.1
—
—
—
0
0
52
433
1.21
0.64
1.5
1.4
—
—
—
0
0
16
113
1.42
0.61
1.5
1.2
10.63
3.67
u/ml
—
8
45
8
50
1.61
0.61
2.8
2.5
—
—
—
0
0
28
218
1.29
0.61
3.5
4.3
0.27
0.34
g/l
0.22
15
98
0
20
0.00
0.60
0.0
1.1
—
38.43
—
0
14
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
22
166
1.33
0.59
1.1
1.1
—
—
—
0
0
8
53
1.51
0.58
1.4
1.4
165.80
184.63
pmol/l
—
8
53
7
116
0.60
0.58
1.1
1.3
—
—
—
0
0
94
833
1.14
0.57
1.3
1.2
—
—
—
0
0
8
54
1.49
0.57
1.1
1.2
—
—
—
0
0
687
6734
1.12
0.57
4.1
3.8
1.46
1.48
mmol/l
0.72
656
6337
662
6479
1.11
0.55
3.7
3.5
1.29
1.28
mmol/l
0.13
629
6080
6
38
1.58
0.54
1.0
1.0
—
—
—
0
0
9
61
1.48
0.54
2.2
1.3
65.78
71.31
umol/l
—
9
61
34
414
0.81
0.53
2.7
2.2
3856.77
2650.05
u/l
0.22
15
175
6
39
1.54
0.53
9.5
7.7
—
—
—
0
0
7
45
1.56
0.49
1.0
1.2
—
—
—
0
0
11
76
1.45
0.48
1.0
1.3
—
—
—
0
0
265
2793
0.92
0.47
2.5
2.5
—
—
—
0
0
208
1953
1.09
0.46
2.8
2.3
58.98
61.26
u/l
0.20
193
1807
145
1340
1.10
0.46
3.9
4.2
2.39
2.13
ug/l
0.14
133
1218
7
49
1.43
0.46
1.0
1.1
—
—
—
0
0
51
441
1.17
0.45
4.6
3.5
1.23
1.23
mmol/l
0.06
44
384
54
470
1.16
0.45
4.9
4.3
0.43
0.54
%
0.27
21
140
10
69
1.45
0.44
6.5
5.5
10.75
10.05
mg/l
—
10
63
5
31
1.62
0.43
2.8
1.4
—
—
—
0
0
6
95
0.63
0.42
1.5
1.2
11.40
18.80
u/l
—
6
81
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
6.7
—
1.20
—
0
15
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
18
141
1.28
0.40
1.3
1.4
3.94
2.83
ug/l
0.34
18
126
89
977
0.90
0.40
1.3
1.3
—
—
—
0
0
16
124
1.30
0.39
1.6
2.3
3.41
4.76
umol/l
0.87
11
89
58
516
1.13
0.37
1.8
1.7
—
—
—
0
0
9
69
1.31
0.37
1.0
1.1
—
—
—
0
0
30
253
1.19
0.37
4.0
3.3
—
—
—
0
0
40
348
1.16
0.35
2.4
2.8
168.79
160.70
ng/l
0.04
34
308
58
519
1.13
0.35
4.9
4.3
0.68
0.93
%
0.59
25
171
6
44
1.37
0.34
1.5
1.3
—
—
—
0
0
56
501
1.13
0.34
1.5
1.4
—
—
—
0
0
28
237
1.19
0.34
1.4
1.3
—
—
—
0
0
23
191
1.21
0.33
3.0
2.1
2.65
5.74
iu/l
—
8
79
23
192
1.20
0.32
1.3
1.4
352.86
291.46
ug/g
0.75
12
109
35
306
1.15
0.30
4.6
6.2
—
—
—
0
0
7
55
1.28
0.30
1.1
3.6
—
—
—
0
0
142
1342
1.07
0.29
2.6
3.0
1559.78
984.06
ng/l
0.60
124
1112
8
62
1.29
0.28
1.0
2.2
—
—
—
0
0
46
413
1.12
0.28
3.3
2.8
79.18
71.59
e9/l
0.50
30
308
9
117
0.77
0.27
1.8
1.6
—
—
—
0
0
10
77
1.30
0.26
5.1
3.2
—
—
—
0
0
54
494
1.10
0.24
5.1
4.4
0.05
0.17
%
1.21
21
145
85
795
1.08
0.24
2.8
2.7
0.71
0.70
ug/l
0.06
50
461
5
40
1.25
0.22
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
6644.00
—
0
11
0
10
0.00
0.21
0.0
1.0
—
7.84
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
22
192
1.15
0.21
7.5
4.6
1.69
1.33
mg/l
0.51
22
177
6
53
1.13
0.18
1.0
1.2
—
—
—
0
0
39
358
1.09
0.18
3.8
3.4
7.38
7.42
ph
—
5
46
16
138
1.16
0.17
1.1
1.0
0.87
2.51
u/ml
—
6
66
7
62
1.13
0.17
1.1
1.1
—
—
—
0
0
7
63
1.11
0.17
1.9
1.3
—
—
—
0
0
149
1440
1.04
0.16
3.3
3.4
1.02
1.02
kg/l
0.01
19
189
12
140
0.86
0.15
6.5
2.7
7.40
7.42
ph
0.94
12
121
48
451
1.07
0.14
3.6
3.1
—
—
—
0
0
39
364
1.07
0.13
3.8
3.4
5.05
5.11
kpa
0.23
39
352
21
190
1.11
0.13
4.7
3.7
1.44
1.35
mmol/l
0.20
21
184
95
917
1.04
0.11
1.6
1.6
1104.70
1182.81
nmol/l
0.45
73
710
205
2093
0.97
0.11
1.6
1.6
—
—
—
0
0
56
587
0.95
0.11
3.5
3.6
—
—
—
0
0
22
202
1.09
0.10
1.2
1.4
100.18
190.19
pmol/l
0.51
22
197
42
398
1.06
0.10
2.2
2.3
11.55
6.34
ug/l
0.45
35
357
49
467
1.05
0.10
5.5
4.6
0.00
0.22
%
1.55
15
119
18
164
1.10
0.09
1.3
1.2
—
—
—
0
0
164
1606
1.03
0.09
3.4
3.3
—
—
—
0
0
5
64
0.78
0.08
3.6
3.0
—
—
—
0
0
190
1931
0.98
0.07
3.1
2.8
—
—
—
0
0
12
108
1.11
0.07
2.1
2.4
46.54
32.77
umol/l
1.10
12
97
16
147
1.09
0.07
1.0
1.1
—
—
—
0
0
119
1165
1.03
0.07
1.5
1.6
453.42
27174343.63
pmol/l
1.31
105
1012
7
83
0.84
0.07
1.0
1.0
1.34
1.44
g/l
—
7
75
172
1742
0.98
0.05
3.5
3.5
0.00
0.00
estimate
1.08
55
657
12
110
1.09
0.05
3.3
2.1
—
—
—
0
0
16
170
0.94
0.04
1.4
1.2
—
—
—
0
0
18
172
1.05
0.02
2.2
2.2
90.39
258.86
ug/l
2.99
18
158
14
145
0.96
0.00
1.7
2.4
38.49
129.03
ug/min
—
7
92
59
592
1.00
0.00
1.5
1.4
—
—
—
0
0
10
101
0.99
0.00
1.1
1.5
—
—
—
0
0
12
119
1.01
0.00
5.3
2.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
3.49
—
0
9
0
5
0.00
0.00
0.0
1.0
—
20.98
—
0
5
0
5
0.00
0.00
0.0
1.8
—
207.20
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
16.30
—
0
5
0
9
0.00
0.00
0.0
15.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
15.36
—
0
8
0
5
0.00
0.00
0.0
1.0
—
362.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.1
302.00
287.35
mg/l
—
5
49
0
6
0.00
-0.00
0.0
1.5
—
1.27
—
0
6
9
94
0.96
-0.00
2.8
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
-0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
172.67
—
0
6
7
75
0.93
-0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAAL_CONJUNCT and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAAL_CONJUNCT 1.087 [0.87, 1.35] 0.453
Birth year 0.995 [0.99, 1.0] 0.218

During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 3306 females with AB1_VIRAAL_CONJUNCT died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAAL_CONJUNCT 1.091 [0.88, 1.35] 0.432
Birth year 0.989 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 2559 males with AB1_VIRAAL_CONJUNCT died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAAL_CONJUNCT.

N-year risk Females Males
1 0.102% 0.262%
5 0.715% 1.337%
10 1.664% 3.385%
15 3.117% 6.616%
20 5.533% 10.786%

Relationships between endpoints

Index endpoint: AB1_VIRAAL_CONJUNCT – Viral conjunctivitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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