No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
577 |
4. Check minimum number of eventsNone |
577 |
5. Include endpointsNone |
577 |
6. Filter based on genotype QC (FinnGen only) |
577 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- D69
- Name in latin
- Status haemorrhagicus non specificatus
Similar endpoints
↥List of similar endpoints to
Other and unspecified haemorrhagic conditions
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4553 | 2524 | 1979 |
| Only index persons | 3723 | 2126 | 1597 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.06 |
| Only index persons | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 55.34 | 53.94 | 56.82 |
| Only index persons | 52.24 | 50.26 | 54.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 577 | 344 | 233 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.10 |
| Median age at first event (years) | 53.80 | 47.74 | 62.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 522
- Matched controls
- 5221
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
8955.6
323.0
442
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
263.8
88.4
88
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
55.2
52
*
28799
ICD-8 Finland
Purpura and other haemorrhagic conditions, Other and unspecified
+∞
50.9
48
*
D69.0
ICD-10 Finland
Allergic purpura
+∞
39.0
37
*
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
32.6
31
*
D68.9
ICD-10 Finland
Coagulation defect, unspecified
+∞
22.0
21
*
B02AA02
ATC
tranexamic acid; systemic
3.2
19.5
116
428
R50.9
ICD-10 Finland
Fever, unspecified
3.2
18.8
111
405
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
18.6
88
272
H02AB06
ATC
prednisolone; systemic
2.2
17.3
267
1660
R4110
NOMESCO Finland
Physiotherapy
2.5
16.7
167
835
H02AB07
ATC
prednisone; oral
3.0
16.3
106
412
D68.8
ICD-10 Finland
Other specified coagulation defects
62.0
15.9
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
15.7
245
1510
C03CA01
ATC
furosemide; systemic
2.3
15.2
178
957
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
14.9
173
925
WW500
NOMESCO Finland
Blood transfusion
5.8
14.9
42
77
ZX120
NOMESCO Finland
Intravenous
3.3
14.8
78
261
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
14.6
134
634
N02AX02
ATC
tramadol; systemic, rectal
2.1
14.6
237
1473
XW000
NOMESCO Finland
Bone marrow biopsy
5.2
13.9
43
88
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
13.8
72
239
2879X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Unspecified haemorrhagic conditions
+∞
13.6
13
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
143.6
13.5
14
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
13.2
73
251
A02BC02
ATC
pantoprazole; systemic
2.0
13.1
346
2570
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.2
13.1
73
254
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
12.5
12
*
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
12.5
12
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
27.4
12.1
16
6
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
12.0
90
378
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.0
12.0
48
128
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
12.0
181
1068
L04AA06
ATC
mycophenolic acid; systemic
12.1
11.9
21
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
11.9
47
124
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
11.7
106
494
28798
ICD-8 Finland
Purpura and other haemorrhagic conditions, Purpura et status haemorrhagicus alius
+∞
11.5
11
*
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
11.5
11
*
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
122.6
11.5
12
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
11.4
90
390
M05BA04
ATC
alendronic acid; oral
3.2
11.3
60
202
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
11.1
142
777
R04.0
ICD-10 Finland
Epistaxis
3.5
11.0
52
160
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
11.0
94
423
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.2
10.9
128
676
L04AX01
ATC
azathioprine; systemic
4.3
10.7
39
96
TK800
NOMESCO Finland
Hemodialysis
10.3
10.6
20
20
126
Kela drug reimbursment
Chronic coagulation defects
+∞
10.4
10
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.4
10.1
36
87
B01AA03
ATC
warfarin; systemic
2.2
9.8
113
587
C07AB07
ATC
bisoprolol; oral
1.8
9.6
234
1614
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.8
9.5
21
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
9.4
194
1263
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
9.4
9
*
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
9.4
9
*
M04AA01
ATC
allopurinol; systemic
2.5
9.2
74
323
J01FF01
ATC
clindamycin; systemic
2.0
9.1
145
857
D07AB08
ATC
desonide; topical
2.6
9.1
70
297
P01AB01
ATC
metronidazole; oral, rectal
1.8
9.0
203
1355
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.2
9.0
46
152
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
9.0
145
861
A46
ICD-10 Finland
Erysipelas
2.4
9.0
82
382
K92.1
ICD-10 Finland
Melaena
3.5
8.5
39
118
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
8.4
96
496
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
+∞
8.4
8
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
11.0
8.3
15
14
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
8.2
92
469
B01AB05
ATC
enoxaparin; parenteral
1.9
8.1
151
938
J01MA12
ATC
levofloxacin; systemic
2.0
8.1
107
586
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.2
8.0
41
136
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
7.9
54
215
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.8
132
793
UJF32
NOMESCO Finland
Coloscopy
1.9
7.7
133
804
C03DA01
ATC
spironolactone; oral
2.4
7.6
64
285
B03BA03
ATC
hydroxocobalamin; parenteral
3.1
7.4
39
132
2878X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Other specified haemorrhagic conditions
+∞
7.3
7
*
D69.5
ICD-10 Finland
Secondary thrombocytopenia
+∞
7.3
7
*
J01DB01
ATC
cefalexin; oral
1.8
7.2
411
3522
6BA02
NOMESCO Finland
NA
30.5
7.2
9
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.8
7.1
19
34
Z49.1
ICD-10 Finland
Extracorporeal dialysis
12.2
7.1
12
10
127
Kela drug reimbursment
Transplant complication
9.0
7.1
14
16
J01DA01
ATC
[U] cefalexin; systemic
1.6
7.0
321
2572
H02AB04
ATC
methylprednisolone; systemic
2.1
6.9
78
400
I34.1
ICD-10 Finland
Mitral (valve) prolapse
4.5
6.9
23
53
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.6
6.9
29
83
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.8
6.8
43
162
D69
ICD-10 Finland
Purpura and other haemorrhagic conditions
40.6
6.8
8
*
J05AB11
ATC
valaciclovir; oral
2.2
6.7
72
360
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
6.7
105
611
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
6.6
58
265
N18.8
ICD-10 Finland
Other chronic renal failure
4.5
6.6
22
51
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
6.6
258
1968
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
6.6
50
213
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
8.9
6.6
13
15
S20.2
ICD-10 Finland
Contusion of thorax
3.3
6.5
31
98
C08CA01
ATC
amlodipine; oral
1.7
6.5
164
1110
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
70.7
6.4
7
*
A02BC01
ATC
omeprazole; systemic
1.7
6.4
137
884
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.1
6.4
23
58
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
6.3
47
195
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
3.4
6.3
29
90
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.4
6.3
50
217
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
6.3
44
179
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
+∞
6.3
6
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
27.0
6.2
8
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
27.0
6.2
8
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
27.0
6.2
8
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.2
108
648
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
6.2
60
288
A02BC03
ATC
lansoprazole; oral
1.7
6.2
139
908
R03AC02
ATC
salbutamol; inhalant
1.6
6.2
256
1973
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
6.1
165
1135
A11CC03
ATC
alfacalcidol; systemic
5.0
6.1
18
37
L04AD01
ATC
ciclosporin; systemic
5.0
6.1
18
37
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
10.2
6.1
11
11
L04AA01
ATC
[U] ciclosporin; systemic
6.1
6.0
15
25
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
4.7
6.0
19
42
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
19
20.74
47.97
1.5
3.4
106.3
92.6
%
0.95
37
19
183
655
3.63
42.07
3.6
2.0
31.2
29.6
s
2.29
178
639
162
675
2.95
27.52
4.1
3.1
0.8
0.8
mmol/l
1.20
154
638
159
683
2.83
25.29
3.3
2.4
11.3
12.9
umol/l
2.21
151
629
143
586
2.91
24.78
3.4
2.5
20.5
21.9
%
0.61
134
506
146
626
2.78
23.09
3.3
2.4
2.3
2.3
g/l
0.60
141
585
345
2203
2.41
23.05
10.8
5.5
26.5
27.9
%
1.44
328
2053
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
53
123
4.64
21.55
3.8
3.0
0.3
0.3
u/ml
0.54
33
67
384
2621
2.39
21.30
15.2
8.5
4.1
4.1
e9/l
0.15
344
2289
334
2175
2.27
20.32
10.6
5.3
58.7
57.4
%
1.24
320
2038
271
1630
2.25
19.90
4.9
3.2
—
—
—
0
0
64
182
3.83
19.87
1.8
1.8
1.5
1.5
g/l
0.16
51
164
344
2325
2.19
18.34
8.6
5.6
11.7
11.2
umol/l
0.28
328
2197
22
25
9.11
17.76
2.3
2.4
—
—
—
0
0
219
1253
2.21
17.71
4.1
3.0
0.5
0.4
e6/l
0.42
175
926
91
350
2.90
17.31
3.9
2.5
65.9
66.8
g/l
0.47
84
318
234
1386
2.16
17.23
4.3
3.2
73.6
108.4
e6/l
0.26
190
1053
41
97
4.47
16.24
2.0
1.6
—
—
—
0
0
307
2061
2.05
15.75
4.1
2.7
174.2
106.1
ug/l
2.72
292
1917
56
170
3.54
15.75
1.3
1.2
0.3
2.5
u/ml
—
6
11
197
1139
2.11
15.04
3.3
2.2
4.0
3.1
mg/l
2.95
174
987
288
1911
2.01
15.04
7.6
4.3
35.1
35.7
g/l
1.07
269
1782
138
720
2.20
13.52
3.5
2.7
3.4
2.4
e6/l
0.45
75
383
143
758
2.18
13.46
3.1
2.6
1.3
1.0
e6/l
0.43
80
419
115
557
2.33
13.46
9.0
5.4
1.1
1.0
mmol/l
1.21
110
512
314
2212
1.92
13.13
11.2
6.0
1.2
1.2
mmol/l
0.98
274
1862
189
1132
2.00
12.73
3.6
2.6
7867.5
8545.9
umol/l
0.05
169
982
101
481
2.33
12.22
2.0
1.7
—
—
—
0
0
287
2000
1.87
12.05
9.6
5.5
1.2
1.2
mmol/l
0.68
271
1808
47
152
3.28
11.96
2.6
2.2
—
—
—
0
0
435
3477
2.02
11.84
12.6
6.8
82.0
78.9
u/l
0.68
422
3253
89
408
2.40
11.72
5.7
4.0
1.8
2.0
mmol/l
0.14
73
325
18
27
6.85
11.52
2.3
2.4
11.8
13.1
%
—
8
17
172
1029
1.96
11.43
2.5
1.7
1.2
1.1
mg/l
0.06
140
783
72
304
2.56
11.29
2.2
1.5
—
—
—
0
0
102
507
2.23
11.10
4.0
2.5
6.3
7.7
umol/l
0.45
86
440
126
688
2.06
10.76
2.1
1.8
—
—
—
0
0
198
1269
1.85
10.51
3.5
3.0
2328.8
1311.7
ng/l
1.35
169
1070
91
441
2.26
10.50
3.9
3.2
—
—
—
0
0
13
15
8.84
10.26
2.7
2.7
738.2
544.0
u/ml
0.60
13
15
40
129
3.26
10.23
4.3
3.4
42.5
105.5
mg/l
0.71
31
107
40
129
3.26
10.23
4.3
3.5
37.4
32.5
mg/l
0.34
31
107
95
477
2.19
10.04
2.0
1.7
—
—
—
0
0
85
408
2.27
10.02
3.0
2.3
30.0
32.0
u/l
0.38
73
339
46
165
2.94
9.84
1.8
1.8
0.5
2.6
ug/l
0.67
41
148
15
22
6.97
9.77
1.8
1.9
—
—
—
0
0
15
22
6.97
9.77
1.8
1.9
—
—
—
0
0
39
128
3.20
9.70
4.4
3.4
1.1
2.3
ratio
—
7
15
307
2279
1.74
9.65
5.2
3.7
0.0
0.0
estimate
0.50
64
410
208
1388
1.78
9.47
3.5
2.4
55.6
57.5
u/l
0.43
196
1293
38
125
3.18
9.42
1.3
1.2
64.1
2.6
u/ml
—
5
16
302
2243
1.73
9.38
5.1
3.6
0.0
0.0
estimate
0.00
68
427
27
71
3.94
9.33
2.0
1.5
—
—
—
0
0
27
71
3.94
9.33
11.1
3.7
256.3
184.4
iu/ml
—
8
5
33
100
3.44
9.31
1.8
1.4
—
—
—
0
0
302
2249
1.72
9.24
6.9
5.0
0.0
0.0
estimate
0.50
67
423
38
127
3.13
9.18
1.3
1.2
8.2
6.3
u/ml
—
8
23
26
68
3.96
9.05
1.4
1.2
3.0
4.4
u/ml
—
8
27
23
55
4.31
8.99
1.4
1.4
—
—
—
0
0
39
135
3.03
8.88
1.4
1.2
59.4
1.2
u/ml
—
5
8
170
1101
1.77
8.40
3.4
2.1
—
—
—
0
0
32
103
3.23
8.23
1.9
1.4
—
—
—
0
0
20
46
4.47
8.21
2.4
1.5
32.8
32.4
pg
0.14
20
46
58
259
2.38
8.05
1.9
1.4
—
—
—
0
0
212
1475
1.69
8.04
4.3
2.8
28.8
30.8
u/l
0.70
202
1405
24
65
3.81
7.98
1.5
1.2
1.5
4.7
u/ml
—
6
23
80
410
2.10
7.97
3.1
2.3
0.2
0.2
g/l
0.15
74
380
19
44
4.43
7.73
1.4
1.4
—
—
—
0
0
17
36
4.84
7.68
1.8
2.7
—
—
—
0
0
334
2643
1.63
7.42
7.8
4.5
6.6
6.7
mmol/l
0.19
318
2445
373
3034
1.65
7.41
6.2
4.4
735.9
2947.2
e6/l
—
9
55
34
121
2.92
7.40
1.4
1.2
—
—
—
0
0
283
2158
1.61
7.27
6.0
3.9
—
—
—
0
0
13
23
5.76
7.09
1.4
1.2
—
—
—
0
0
247
1842
1.60
6.84
3.0
2.3
73.4
77.0
nmol/l
1.19
233
1639
10
6
16.93
6.76
1.6
1.7
—
—
—
0
0
30
105
2.96
6.73
1.4
1.2
47.3
27.1
u/ml
—
8
12
234
1729
1.59
6.70
4.9
3.7
34.8
37.4
ng/l
0.15
157
1180
238
1774
1.58
6.52
2.4
2.0
94.7
95.1
pmol/l
0.05
155
901
209
1513
1.60
6.47
4.4
3.2
2.3
2.4
mmol/l
0.16
189
1328
17
42
4.14
6.39
2.7
1.6
—
—
—
0
0
25
81
3.18
6.39
1.6
1.3
215.6
233.4
u/ml
0.12
14
45
25
81
3.18
6.39
1.3
1.6
—
—
—
0
0
157
1062
1.66
6.39
1.8
1.5
20.4
20.8
nmol/l
0.08
134
905
25
82
3.14
6.26
1.6
1.3
—
—
—
0
0
51
242
2.21
6.16
1.8
1.6
—
—
—
0
0
29
105
2.86
6.14
2.3
1.4
—
—
—
0
0
31
120
2.67
5.81
1.7
1.3
—
—
—
0
0
37
157
2.45
5.77
5.0
2.1
3.4
3.2
g/l
0.49
30
123
16
41
3.99
5.75
1.3
1.2
—
—
—
0
0
16
41
3.99
5.75
1.3
1.2
—
—
—
0
0
16
42
3.89
5.57
1.3
1.2
—
—
—
0
0
16
42
3.89
5.57
1.3
1.2
—
—
—
0
0
16
42
3.89
5.57
1.3
1.2
—
—
—
0
0
41
186
2.30
5.52
2.9
2.1
44.5
40.0
u/l
0.60
35
167
40
180
2.31
5.49
2.2
2.3
6184.1
3381.5
u/l
0.33
16
72
38
168
2.35
5.43
4.9
2.0
7.6
7.4
g/l
0.26
30
125
38
168
2.35
5.43
4.9
2.0
3.7
3.8
g/l
0.17
30
121
38
168
2.35
5.43
4.9
2.0
—
—
—
0
0
17
48
3.62
5.36
2.8
1.5
—
—
—
0
0
66
364
1.92
5.35
3.1
2.6
69.3
67.4
ml/min/173m2
0.15
43
155
92
570
1.73
5.11
37.6
23.2
1.8
1.3
inr
—
10
83
122
820
1.62
4.97
1.9
1.7
1094.0
1167.4
nmol/l
0.39
95
624
182
1344
1.52
4.91
2.8
2.0
259.2
315.3
u/l
0.19
177
1268
394
3413
1.49
4.62
6.6
3.9
15.2
11.7
mm/h
3.53
375
3148
18
59
3.12
4.55
1.2
1.5
—
—
—
0
0
14
39
3.65
4.51
2.3
2.3
—
—
—
0
0
21
76
2.83
4.49
1.2
1.5
—
—
—
0
0
12
30
4.06
4.45
1.4
1.5
—
—
—
0
0
224
1766
1.44
4.21
5.7
3.8
—
—
—
0
0
432
3850
1.49
4.08
32.0
16.3
14.1
13.7
%
5.46
425
3787
164
1228
1.47
4.02
6.0
4.0
0.0
0.0
estimate
0.50
63
414
11
28
3.99
3.99
1.3
1.1
—
—
—
0
0
111
769
1.55
3.93
1.3
1.3
24.6
33.3
iu/ml
0.61
37
247
13
38
3.48
3.92
1.0
1.5
—
—
—
0
0
20
77
2.65
3.84
2.4
1.4
107.4
113.1
u/ml
—
5
13
76
484
1.66
3.81
10.4
6.9
1.5
1.2
mmol/l
0.28
56
388
462
4202
1.50
3.68
25.6
14.4
38.4
39.7
%
2.32
336
3091
120
860
1.50
3.62
4.3
3.6
1618.2
342.8
ng/l
0.54
95
643
502
4656
1.60
3.58
29.0
15.4
139.3
139.7
mmol/l
2.34
490
4519
124
898
1.49
3.55
1.7
1.6
—
—
—
0
0
29
138
2.16
3.55
3.7
2.9
—
—
—
0
0
45
252
1.85
3.53
4.3
3.0
0.3
0.2
e6/l
0.65
45
244
118
849
1.49
3.49
3.6
2.9
2.5
2.4
mmol/l
0.15
102
744
33
167
2.04
3.46
4.2
3.6
1.1
1.3
mmol/l
1.09
33
160
48
277
1.80
3.43
1.3
1.2
305.1
223.6
u/ml
0.15
41
250
502
4667
1.58
3.41
29.8
15.5
4.0
4.0
mmol/l
0.47
489
4523
15
53
2.88
3.38
1.2
1.6
—
—
—
0
0
15
54
2.83
3.27
1.3
1.1
1.4
1.4
g/l
0.04
15
48
45
259
1.80
3.25
4.0
3.4
4.5
4.5
pmol/l
0.15
37
231
347
3037
1.36
3.17
4.3
3.0
52.5
45.4
u/l
1.21
324
2844
494
4595
1.52
3.14
28.1
13.4
23.4
22.9
mg/l
0.13
439
3638
12
39
3.12
3.10
1.2
1.5
76.0
64.5
%
—
5
31
61
391
1.63
3.01
12.1
7.6
113.5
121.1
g/l
2.07
61
382
9
21
4.34
3.00
1.8
1.1
—
—
—
0
0
9
21
4.34
3.00
1.8
1.1
—
—
—
0
0
20
88
2.32
2.97
1.4
1.3
—
—
—
0
0
20
88
2.32
2.97
1.4
1.3
—
—
—
0
0
8
17
4.76
2.92
1.8
1.1
—
—
—
0
0
8
17
4.76
2.92
1.8
1.1
—
—
—
0
0
16
65
2.50
2.81
1.3
1.5
—
—
—
0
0
10
31
3.27
2.78
1.0
1.0
—
—
—
0
0
15
60
2.54
2.72
1.4
1.3
—
—
—
0
0
461
4273
1.39
2.60
22.9
12.3
81.3
81.7
ml/min/173m2
0.10
413
3475
24
121
2.03
2.59
1.8
1.3
—
—
—
0
0
5
7
7.19
2.55
1.6
1.0
—
—
—
0
0
6
11
5.50
2.55
2.2
2.5
51.2
95.9
ug/l
—
6
11
14
56
2.54
2.55
1.1
1.3
—
—
—
0
0
67
460
1.52
2.49
3.4
4.2
29.5
23.2
ug/l
0.12
56
387
24
124
1.98
2.44
3.7
2.9
8.0
8.4
kpa
0.54
24
109
45
283
1.64
2.42
4.5
3.5
1.4
1.9
mmol/l
0.34
32
203
10
34
2.98
2.42
1.7
1.3
—
—
—
0
0
121
934
1.37
2.41
1.8
1.7
431.2
6258262.6
pmol/l
0.50
94
799
135
1063
1.35
2.37
1.3
1.3
1.8
1.7
u/ml
0.03
32
293
17
78
2.22
2.33
1.9
2.4
14.8
16.0
%
—
7
40
10
35
2.89
2.31
1.4
1.4
—
—
—
0
0
11
41
2.72
2.29
2.6
1.5
—
—
—
0
0
11
41
2.72
2.29
2.6
1.5
—
—
—
0
0
11
41
2.72
2.29
2.6
1.5
—
—
—
0
0
7
18
3.92
2.26
3.4
1.5
—
—
—
0
0
7
18
3.92
2.26
3.4
1.5
—
—
—
0
0
0
62
0.00
2.23
0.0
1.4
—
7.7
—
0
40
76
550
1.44
2.19
1.7
1.7
1.5
1.4
%
0.65
65
486
7
19
3.72
2.15
3.4
1.5
—
—
—
0
0
10
37
2.73
2.11
1.1
1.2
—
—
—
0
0
11
43
2.59
2.10
1.3
1.0
—
—
u/ml
—
0
0
9
31
2.93
2.08
2.4
1.2
—
—
—
0
0
5
10
5.03
2.07
1.4
1.0
—
—
—
0
0
22
118
1.90
2.04
1.3
1.2
—
—
—
0
0
19
97
1.99
2.02
1.3
1.4
—
—
—
0
0
7
21
3.36
1.97
9.9
3.2
225.4
210.7
u/l
—
7
21
7
21
3.36
1.97
1.1
1.1
—
—
—
0
0
7
22
3.21
1.88
1.0
1.3
—
—
—
0
0
328
2964
1.25
1.87
3.4
3.2
—
—
—
0
0
13
59
2.23
1.85
3.9
1.3
—
—
—
0
0
13
59
2.23
1.85
3.9
1.3
—
—
—
0
0
13
59
2.23
1.85
3.9
1.3
—
—
—
0
0
5
12
4.19
1.82
1.4
1.2
—
—
—
0
0
160
1335
1.27
1.82
3.7
3.1
7.2
7.4
mmol/l
0.22
136
1110
23
131
1.79
1.80
2.0
1.6
0.1
0.1
iu/ml
—
8
27
8
29
2.78
1.79
2.0
3.1
—
—
—
0
0
13
60
2.19
1.79
3.9
1.3
—
—
—
0
0
13
60
2.19
1.79
3.9
1.3
—
—
—
0
0
13
60
2.19
1.79
3.9
1.3
—
—
—
0
0
95
743
1.33
1.74
1.3
1.3
4.4
9.6
u/ml
1.08
32
296
155
1296
1.27
1.73
4.9
4.0
22.5
8.8
mg/mmol
1.17
116
806
19
104
1.86
1.69
1.3
1.3
—
—
—
0
0
6
19
3.18
1.66
1.2
1.7
—
—
—
0
0
7
25
2.82
1.65
3.4
1.4
—
—
—
0
0
7
25
2.82
1.65
3.4
1.4
—
—
—
0
0
7
25
2.82
1.65
3.4
1.4
—
—
—
0
0
7
25
2.82
1.65
3.4
1.4
—
—
—
0
0
23
136
1.72
1.61
1.8
1.8
—
—
—
0
0
18
99
1.84
1.59
1.5
1.6
8666.7
21434.0
e6/l
0.98
12
71
7
26
2.71
1.58
1.3
1.5
—
—
—
0
0
6
20
3.02
1.58
1.2
1.2
634.3
118.1
iu/ml
—
6
20
21
122
1.75
1.56
1.1
1.4
14.9
10.5
u/l
0.66
16
95
379
3516
1.23
1.54
4.9
3.9
14.7
14.7
pmol/l
0.11
355
3199
21
123
1.73
1.53
1.4
1.1
—
—
—
0
0
6
21
2.88
1.51
1.3
1.6
—
—
—
0
0
6
22
2.74
1.43
1.3
1.5
—
—
—
0
0
24
149
1.64
1.43
1.1
1.2
—
—
—
0
0
45
323
1.43
1.41
2.0
1.9
—
—
—
0
0
24
150
1.63
1.40
1.1
1.2
—
—
—
0
0
11
53
2.10
1.39
1.1
1.1
—
—
—
0
0
9
41
2.21
1.37
1.2
1.3
—
—
—
0
0
122
1019
1.25
1.36
5.4
4.0
1.0
1.0
kg/l
0.68
16
149
5
17
2.96
1.36
2.4
1.2
11.8
8.5
ug/l
—
5
17
504
4854
1.30
1.32
17.6
9.6
25.3
25.3
u/l
0.01
496
4684
27
177
1.55
1.31
2.1
1.8
—
—
—
0
0
14
76
1.86
1.31
1.1
1.1
—
—
—
0
0
6
24
2.52
1.30
1.2
1.9
1.0
1.6
u/field
—
6
19
6
25
2.41
1.24
1.2
1.7
—
—
—
0
0
9
45
2.02
1.23
5.0
2.6
24.3
53.4
u/ml
—
9
45
10
49
2.06
1.22
1.4
1.1
—
—
—
0
0
444
4228
1.22
1.20
5.7
4.6
1.9
2.2
mu/l
0.43
418
3866
8
40
2.01
1.12
2.3
2.2
1161.3
560.4
ml
—
8
24
17
105
1.64
1.07
3.5
1.3
—
—
—
0
0
13
75
1.75
1.03
1.2
1.1
—
—
—
0
0
35
257
1.39
1.01
2.0
1.8
—
—
—
0
0
7
36
1.96
0.97
2.4
1.1
—
—
—
0
0
0
31
0.00
0.96
0.0
1.7
—
—
—
0
0
7
37
1.90
0.94
2.4
1.2
—
—
—
0
0
433
4147
1.18
0.94
6.5
5.6
39.9
39.8
mmol/mol
0.16
397
3870
6
28
2.15
0.91
1.5
1.7
1.0
1.0
g/l
—
6
28
130
1141
1.18
0.89
1.5
1.6
1.5
1.4
mmol/l
1.44
109
967
18
119
1.53
0.89
1.9
1.7
3.8
6.5
iu/l
—
7
40
22
155
1.44
0.82
2.2
1.6
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
33.6
—
0
15
0
24
0.00
0.79
0.0
1.0
—
516.4
—
0
16
42
332
1.29
0.78
1.2
1.2
131.9
163.9
iu/ml
0.25
16
134
454
4386
1.16
0.78
5.0
4.4
6.0
5.9
mmol/l
0.33
416
4013
9
53
1.71
0.75
1.2
1.2
0.9
0.5
nmol/l
—
9
47
36
284
1.29
0.70
1.3
1.4
—
45.9
—
0
14
5
95
0.52
0.67
1.0
1.3
4.8
3.8
mmol/l
—
5
88
8
49
1.64
0.62
1.4
1.4
25.2
20.8
ug/l
—
8
49
10
63
1.60
0.62
1.3
1.1
—
—
—
0
0
22
165
1.35
0.61
1.8
1.7
—
—
—
0
0
33
264
1.27
0.59
1.3
1.3
—
—
—
0
0
70
607
1.17
0.58
2.2
2.1
—
—
—
0
0
32
257
1.26
0.56
3.9
2.6
32.9
49.9
u/ml
0.49
32
244
459
4470
1.13
0.56
4.8
4.3
4.4
4.6
mmol/l
6.42
429
4152
48
562
0.84
0.52
4.2
4.2
29.3
32.4
%
1.19
37
378
12
168
0.71
0.51
1.8
1.5
—
—
—
0
0
439
4280
1.11
0.47
4.4
3.8
1.3
1.3
mmol/l
1.05
404
3940
31
255
1.23
0.46
1.1
1.0
—
—
—
0
0
454
4439
1.11
0.44
4.6
4.2
1.4
1.5
mmol/l
7.40
422
4099
5
31
1.62
0.43
1.4
1.3
—
60.0
—
0
6
5
32
1.57
0.42
1.2
1.5
—
21.0
—
0
5
34
401
0.84
0.42
1.9
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
21
169
1.25
0.39
1.3
1.3
208.3
277.4
miu/ml
—
9
83
464
4551
1.10
0.38
5.2
4.7
2.6
2.7
mmol/l
4.33
426
4203
15
117
1.29
0.35
1.2
1.6
—
—
—
0
0
12
153
0.78
0.31
1.3
1.4
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
—
—
0
0
19
157
1.22
0.30
1.4
1.5
—
—
—
0
0
11
86
1.28
0.26
1.0
1.1
0.1
2.8
u/ml
—
6
35
32
282
1.14
0.26
1.6
2.2
11.0
13.0
nmol/l
0.76
26
258
84
784
1.08
0.25
1.7
1.5
—
—
—
0
0
12
148
0.81
0.24
1.9
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
1.2
—
0
10
8
103
0.77
0.21
1.0
1.4
645.8
416.7
mg/l
—
8
98
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
60
558
1.08
0.20
2.2
1.9
—
—
—
0
0
6
52
1.16
0.19
3.8
4.1
—
—
—
0
0
133
1281
1.05
0.17
4.6
4.8
2.2
2.6
ug/l
0.52
120
1145
19
167
1.14
0.17
1.7
1.8
—
—
—
0
0
5
67
0.74
0.17
1.6
1.6
9.3
25.0
u/l
—
5
58
8
69
1.16
0.16
2.3
1.5
—
—
—
0
0
70
735
0.95
0.14
3.0
2.9
0.7
0.8
ug/l
0.81
49
470
12
138
0.87
0.13
1.8
1.4
—
—
—
0
0
12
138
0.87
0.13
1.8
1.4
—
—
—
0
0
12
138
0.87
0.13
1.8
1.4
—
—
—
0
0
12
138
0.87
0.13
1.8
1.4
—
—
—
0
0
23
252
0.91
0.13
1.7
1.5
—
—
—
0
0
10
87
1.15
0.09
1.2
1.5
—
—
—
0
0
8
75
1.07
0.07
1.5
1.9
—
—
—
0
0
52
533
0.97
0.04
10.5
6.9
—
—
—
0
0
101
1017
0.99
0.01
3.9
4.3
23.1
22.5
%
0.14
46
476
10
106
0.94
0.01
2.0
1.8
—
—
—
0
0
11
112
0.98
0.00
1.1
1.8
44.2
40.2
nmol/l
0.30
11
107
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
0.6
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
52.4
—
0
5
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HAEMORRHAGICNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGICNAS | 2.577 [2.13, 3.11] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 542 out of 1833 females with D3_HAEMORRHAGICNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGICNAS | 2.773 [2.18, 3.53] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 549 out of 1402 males with D3_HAEMORRHAGICNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_HAEMORRHAGICNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.304% | 0.488% |
| 5 | 1.55% | 3.02% |
| 10 | 3.838% | 7.322% |
| 15 | 6.969% | 14.394% |
| 20 | 12.299% | 23.449% |
Relationships between endpoints
↥Index endpoint: D3_HAEMORRHAGICNAS – Other and unspecified haemorrhagic conditions
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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