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Acute otitis externa, noninfective

DOID EFO Endpoint Browser PheWeb

H8_EXT_NONINF

otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H60.5
  • Cause of death: ICD-10 — H60.5

2 out of 7 registries used, show all original rules.

600

4. Check minimum number of events

None

600

5. Include endpoints

None

600

6. Filter based on genotype QC (FinnGen only)

600

Control definitions (FinnGen only)

Control exclude
H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H60
Name in latin
Otitis externa acuta non infectiosa

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4704 2439 2237
Only index persons 4262 2271 1991
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.06
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 45.42 45.65 45.04
Only index persons 44.12 44.57 43.62

-FinnGen-

Key figures

All Female Male
Number of individuals 600 349 251
Unadjusted period prevalence (%) 0.12 0.12 0.11
Median age at first event (years) 48.80 48.54 49.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
538
Matched controls
5378
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
+∞
323.0
538
10
H60.9
ICD-10 Finland
Otitis externa, unspecified
18.5
94.8
153
113
H60.3
ICD-10 Finland
Other infective otitis externa
92.7
90.8
99
13
H60.8
ICD-10 Finland
Other otitis externa
37.1
66.4
85
27
S02CA02
ATC
flumetasone and antiinfectives; otic
9.6
47.6
103
130
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
13.0
41.4
75
66
UDC00
NOMESCO Finland
Ear microscopy
5.8
36.1
112
234
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
14.6
34.6
59
45
H66.0
ICD-10 Finland
Acute suppurative otitis media
6.1
28.1
81
152
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.9
27.9
128
394
H70
ICPC
Otitis externa
15.2
24.8
41
29
J01MA02
ATC
ciprofloxacin; systemic
2.6
24.2
255
1371
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
12.2
24.1
44
39
J01DA01
ATC
[U] cefalexin; systemic
2.5
21.5
384
2676
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
12.3
21.1
38
33
H60
ICD-10 Finland
Otitis externa
6.7
18.5
48
78
H13
ICPC
Plugged feeling ear
2.8
16.5
123
520
H60.1
ICD-10 Finland
Cellulitis of external ear
14.9
16.5
27
19
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.8
15.8
117
493
Z97.4
ICD-10 Finland
Presence of external hearing-aid
5.0
15.5
51
111
H04
ICPC
Ear discharge
7.3
15.4
37
54
H29
ICPC
Ear symptom/complaint other
3.4
15.2
77
250
H01
ICPC
Ear pain/earache
3.2
15.0
87
310
H71
ICD-10 Finland
Cholesteatoma of middle ear
11.8
14.9
27
24
H61.2
ICD-10 Finland
Impacted cerumen
4.6
14.9
52
121
H65.0
ICD-10 Finland
Acute serous otitis media
10.5
14.6
28
28
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
37.1
14.5
18
5
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.3
14.3
34
49
H66.9
ICD-10 Finland
Otitis media, unspecified
4.2
13.9
54
140
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
18.8
13.5
20
11
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.2
12.9
170
951
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
71.6
12.6
14
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
20.6
12.5
18
9
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
3.8
12.0
52
149
H61.8
ICD-10 Finland
Other specified disorders of external ear
19.4
11.6
17
9
H60.0
ICD-10 Finland
Abscess of external ear
35.8
11.3
14
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
10.9
128
672
S02CA06
ATC
dexamethasone and antiinfectives; otic
18.3
10.8
16
9
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
10.7
166
981
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.0
10.5
159
928
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
112.1
10.5
11
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.2
10.3
111
559
T90
ICPC
Diabetes non-insulin dependent
2.1
9.8
119
634
H92.0
ICD-10 Finland
Otalgia
3.7
9.7
42
121
H65.2
ICD-10 Finland
Chronic serous otitis media
8.3
9.4
20
25
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
9.1
196
1288
H74.1
ICD-10 Finland
Adhesive middle ear disease
19.0
9.0
13
7
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.7
8.8
301
2273
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
5.3
8.6
25
49
DCD00
NOMESCO Finland
Myringoplasty
9.7
8.3
16
17
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.7
8.2
34
95
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
8.2
106
577
H70.1
ICD-10 Finland
Chronic mastoiditis
22.4
8.0
11
5
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
7.9
98
521
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.8
131
783
S18
ICPC
Laceration/cut
1.7
7.8
219
1544
J01CA04
ATC
amoxicillin; systemic
1.8
7.8
428
3660
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
7.8
226
1605
J01DB01
ATC
cefalexin; oral
1.8
7.8
428
3662
J01FA10
ATC
azithromycin; systemic
1.7
7.8
309
2401
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
7.8
135
818
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
45.6
7.7
9
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
45.6
7.7
9
*
D07AC01
ATC
betamethasone; topical
1.7
7.6
185
1247
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
7.5
99
538
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.7
7.3
206
1444
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.3
266
2003
DFF00
NOMESCO Finland
Pure tone audiometry
2.5
7.3
57
245
D07CC01
ATC
betamethasone and antibiotics; topical
2.2
7.2
75
371
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
7.1
120
718
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
7.1
362
2980
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.9
139
880
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
6.9
214
1537
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
6.8
148
958
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
6.7
198
1401
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.5
6.7
50
210
H81
ICPC
Excessive ear wax
2.0
6.7
86
464
TDA90
NOMESCO Finland
Removal wax from ear
6.6
6.7
16
25
E66.01
ICD-10 Finland
Obesity due to excess calories
2.6
6.7
49
202
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
6.7
58
264
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
8.0
6.6
14
18
DAX08
NOMESCO Finland
Fitting of hearing aid
3.5
6.6
29
86
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
6.6
74
378
DC1AD
NOMESCO Finland
Temporalbone CT
8.8
6.6
13
15
I25.2
ICD-10 Finland
Old myocardial infarction
2.8
6.6
40
150
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
3.8
6.6
26
71
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.5
151
993
K03.18
ICD-10 Finland
Other abrasion of the teeth
7.5
6.4
14
19
A10BA02
ATC
metformin; oral
1.8
6.4
136
870
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
6.4
169
1155
K02.1
ICD-10 Finland
Caries of dentine
1.6
6.4
293
2313
C03CA01
ATC
furosemide; systemic
1.7
6.3
141
918
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.3
91
514
R5120
NOMESCO Finland
Preparation of an aid
4.2
6.3
22
54
H73.1
ICD-10 Finland
Chronic myringitis
+∞
6.3
6
*
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
+∞
6.3
6
*
DEB30
NOMESCO Finland
Radical mastoidectomy
+∞
6.3
6
*
J02AC01
ATC
fluconazole; systemic
1.6
6.1
207
1511
A46
ICD-10 Finland
Erysipelas
2.0
6.1
74
391

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
152
515
3.61
37.39
2.4
1.6
—
—
—
0
0
106
561
2.08
9.73
1.6
1.4
—
—
—
0
0
118
670
1.95
8.86
2.2
2.0
—
—
—
0
0
213
1470
1.70
8.30
4.1
2.5
65.0
56.5
u/l
0.40
200
1363
201
1389
1.67
7.68
2.3
2.0
214.2
240.4
u/l
0.13
193
1308
242
1787
1.59
6.92
4.6
3.5
68.9
56.7
ng/l
0.13
174
1218
342
2744
1.57
6.77
5.5
4.5
6.8
6.7
mmol/l
0.36
318
2540
94
558
1.81
6.04
8.3
5.2
1.1
1.0
mmol/l
1.24
89
514
199
1441
1.57
6.01
4.1
4.0
8.4
8.7
mg/mmol
0.03
121
896
103
640
1.74
5.66
1.3
1.2
—
—
—
0
0
187
1368
1.53
5.28
3.6
3.2
781.3
201.7
mg/l
0.56
117
866
57
300
1.99
5.27
4.1
3.5
7.4
7.4
ph
—
9
24
167
1203
1.54
5.02
2.7
2.6
5258.2
7073.6
umol/l
0.20
144
1044
66
373
1.86
4.96
4.5
3.2
—
—
—
0
0
73
429
1.80
4.84
6.4
4.2
—
—
—
0
0
279
2246
1.45
4.79
8.5
6.5
1.2
1.2
mmol/l
0.91
233
1911
54
294
1.92
4.55
5.3
4.5
—
—
—
0
0
21
77
2.79
4.39
3.3
2.3
—
—
—
0
0
186
1409
1.46
4.29
3.2
2.8
—
—
—
0
0
119
821
1.56
4.29
1.8
1.7
1141.5
1191.9
nmol/l
0.28
98
625
233
1842
1.43
4.28
8.9
7.9
1.2
1.2
inr
0.16
61
541
410
3587
1.45
4.28
5.0
4.0
12.0
11.7
mm/h
0.19
379
3309
194
1487
1.45
4.19
3.6
3.1
7.3
7.6
mmol/l
0.39
163
1247
418
3678
1.45
4.17
4.5
3.9
14.6
14.7
pmol/l
0.66
379
3335
57
326
1.83
4.14
5.1
3.0
4.7
4.1
e9/l
1.01
41
253
165
1229
1.47
4.13
4.2
4.1
—
—
—
0
0
69
422
1.72
4.01
4.2
3.5
—
—
—
0
0
233
1865
1.41
3.91
2.1
1.9
98.9
95.8
pmol/l
0.43
140
951
251
2043
1.39
3.79
7.3
5.6
1.2
1.2
mmol/l
0.81
230
1859
114
800
1.52
3.79
1.3
1.2
2.3
10.7
u/ml
3.24
56
311
292
2443
1.38
3.71
6.6
5.7
1.9
1.9
e9/l
0.14
267
2187
150
1121
1.45
3.64
2.4
2.3
—
—
—
0
0
103
714
1.53
3.61
3.8
3.4
0.8
0.8
mmol/l
1.22
95
675
128
934
1.47
3.51
1.7
1.7
50000476.1
24081553.6
pmol/l
0.21
106
789
293
2469
1.36
3.49
6.4
6.1
0.2
0.2
e9/l
0.35
260
2203
283
2372
1.37
3.48
6.2
5.7
0.6
0.6
e9/l
1.93
251
2078
28
134
2.14
3.39
5.1
6.9
1.7
1.2
mmol/l
1.08
22
118
32
162
2.03
3.36
6.8
4.3
—
—
—
0
0
27
128
2.16
3.35
1.4
1.5
213.1
283.5
ug/g
1.05
12
80
283
2385
1.35
3.31
6.2
5.7
0.0
0.0
e9/l
0.50
251
2093
58
360
1.68
3.22
5.1
3.5
131.4
74.9
ng/l
1.46
44
327
58
360
1.68
3.22
2.8
2.8
79.9
72.5
e9/l
0.62
52
278
238
1961
1.35
3.19
5.7
4.7
35.3
35.8
g/l
0.65
223
1825
66
427
1.61
3.12
2.0
2.0
338.7
369.7
nmol/l
0.66
58
397
6
8
7.56
3.06
6.8
1.9
—
—
—
0
0
272
2300
1.33
3.03
6.6
5.9
27.1
28.0
%
0.74
252
2153
45
265
1.75
3.02
1.4
1.2
—
—
—
0
0
92
647
1.50
3.02
1.5
1.3
652.5
521.1
titre
0.17
16
141
174
1375
1.37
3.02
5.6
3.7
—
—
—
0
0
31
162
1.96
3.00
4.9
4.1
1.3
1.3
mmol/l
0.07
31
157
22
101
2.22
2.96
3.2
3.8
—
—
—
0
0
11
35
3.18
2.94
1.8
1.4
25.4
29.8
%
—
5
24
113
832
1.44
2.94
1.3
1.3
26.1
35.8
iu/ml
0.34
36
274
40
230
1.79
2.91
4.1
3.6
—
—
—
0
0
291
2497
1.32
2.88
7.1
6.2
10.6
10.9
umol/l
0.24
279
2371
62
405
1.59
2.83
4.5
3.5
2.4
2.0
mmol/l
0.17
48
319
142
1097
1.39
2.81
5.2
4.6
—
—
—
0
0
8
18
4.49
2.80
1.0
1.1
—
—
—
0
0
8
18
4.49
2.80
1.0
1.1
—
—
—
0
0
184
1486
1.34
2.74
2.5
2.3
—
—
—
0
0
26
132
2.01
2.74
2.9
3.4
1.1
1.1
ratio
—
6
18
13
48
2.75
2.73
1.6
1.5
—
—
—
0
0
90
647
1.46
2.65
3.5
2.2
2.4
2.4
g/l
0.63
85
600
148
1164
1.36
2.61
2.6
2.0
3.0
3.0
mg/l
0.09
129
995
478
4438
1.38
2.58
6.9
5.6
40.9
39.8
mmol/mol
1.69
441
4131
407
3690
1.32
2.57
8.9
7.4
83.5
77.6
u/l
0.55
389
3458
261
2231
1.30
2.57
6.3
5.8
2.9
2.8
%
0.10
239
2077
7
16
4.41
2.48
1.1
1.1
1343.9
1343.9
miu/ml
—
7
16
15
63
2.42
2.48
1.2
1.4
0.2
0.4
nmol/l
—
10
50
190
1565
1.31
2.43
6.1
5.9
—
—
—
0
0
476
4429
1.36
2.43
5.5
4.7
1.8
1.9
mu/l
0.58
440
4051
260
2237
1.29
2.39
6.8
6.1
8.7
8.5
%
0.42
241
2103
315
2777
1.28
2.38
9.9
9.2
4.1
4.0
e9/l
0.44
282
2454
84
610
1.44
2.36
3.6
2.2
22.3
22.6
%
0.08
74
529
19
91
2.12
2.35
2.1
1.2
107.0
104.9
u/ml
—
6
20
263
2274
1.28
2.30
6.5
5.7
58.3
57.1
%
0.90
242
2142
146
1791
0.76
2.27
3.1
2.8
—
—
—
0
0
55
370
1.54
2.25
2.8
3.0
66.4
67.2
g/l
0.33
48
339
5
9
5.59
2.21
1.8
1.9
—
—
—
0
0
363
3276
1.27
2.20
5.5
4.2
—
—
—
0
0
94
710
1.38
2.12
3.7
2.2
13.4
13.2
umol/l
0.10
88
659
378
4104
0.79
2.10
18.2
16.3
13.8
13.6
%
1.31
365
4030
250
2166
1.26
2.10
6.6
5.8
0.7
0.7
%
0.18
229
2025
73
532
1.42
2.03
1.4
1.3
—
—
—
0
0
19
97
1.99
2.02
1.9
1.3
—
—
—
0
0
15
70
2.17
2.00
1.1
1.0
2.8
4.6
u/ml
—
9
30
185
1555
1.27
1.98
3.6
3.3
2.3
2.4
mmol/l
1.53
160
1361
522
4974
1.38
1.92
20.6
15.2
4.0
4.0
mmol/l
0.26
509
4834
521
4963
1.38
1.92
20.8
15.1
139.6
139.7
mmol/l
0.24
509
4830
74
547
1.40
1.91
21.1
20.8
1.4
1.2
inr
0.56
17
77
15
72
2.11
1.87
1.7
3.4
1.5
1.0
%
—
9
59
17
86
2.01
1.86
3.4
4.0
58.2
58.3
%
0.01
17
86
131
1064
1.30
1.82
1.5
1.5
20.8
21.2
nmol/l
0.10
108
907
18
95
1.92
1.77
1.6
1.7
—
—
—
0
0
135
1106
1.28
1.76
1.3
1.2
1.0
1.9
u/ml
0.96
40
308
9
36
2.52
1.74
1.0
1.7
—
—
—
0
0
12
55
2.21
1.68
1.6
1.5
75.0
61.3
%
—
6
43
11
225
0.48
1.66
1.0
1.1
—
—
—
0
0
67
500
1.38
1.65
3.9
2.8
2.0
1.8
%
0.42
61
455
220
1922
1.23
1.63
2.3
2.0
—
—
—
0
0
16
84
1.93
1.61
3.3
3.6
4.1
4.3
e9/l
0.14
16
84
16
84
1.93
1.61
1.5
1.6
—
—
—
0
0
50
357
1.44
1.58
4.3
4.1
0.5
0.5
%
0.03
11
82
129
1066
1.27
1.57
1.6
1.7
1.0
1.2
mg/l
1.16
107
807
152
1284
1.25
1.53
5.5
3.7
0.0
0.0
estimate
0.69
57
441
54
394
1.41
1.53
4.1
4.1
1.1
1.0
%
0.08
17
122
5
15
3.35
1.52
1.0
1.0
—
4.3
—
0
5
156
1323
1.24
1.51
3.9
3.0
1200.5
1087.0
ng/l
0.19
139
1125
51
369
1.42
1.51
4.2
4.3
0.1
0.2
%
0.78
16
109
13
65
2.02
1.49
1.1
1.0
9.8
0.5
u/ml
—
6
22
510
4882
1.30
1.49
18.4
13.2
19.8
23.0
mg/l
1.62
429
3828
491
4687
1.26
1.40
5.3
4.4
6.2
5.9
mmol/l
2.25
448
4278
118
978
1.26
1.40
1.5
1.4
2.5
2.4
g/l
0.09
80
597
66
506
1.34
1.40
7.2
7.3
1.9
1.2
mmol/l
0.68
50
411
63
814
0.75
1.39
3.0
2.8
0.6
0.7
ug/l
0.53
44
516
6
23
2.62
1.37
1.0
1.7
—
—
—
0
0
6
23
2.62
1.37
1.0
1.9
1.0
1.1
nmol/l
—
6
17
17
97
1.77
1.36
1.5
1.2
274.5
254.0
u/ml
—
10
56
16
90
1.80
1.34
7.1
2.5
—
—
—
0
0
43
310
1.42
1.32
2.7
2.4
—
—
—
0
0
248
2229
1.19
1.31
4.2
3.9
—
—
—
0
0
5
18
2.79
1.28
1.0
1.2
—
—
—
0
0
34
236
1.47
1.28
2.5
2.3
—
—
—
0
0
30
205
1.49
1.22
1.4
1.2
—
—
—
0
0
11
57
1.95
1.17
4.6
3.1
—
—
—
0
0
25
166
1.53
1.17
4.7
3.6
0.1
0.2
g/l
—
10
63
8
39
2.07
1.15
1.5
1.5
—
—
—
0
0
14
80
1.77
1.13
1.2
1.1
3.2
1.4
u/ml
—
7
26
335
3119
1.17
1.10
5.3
4.3
8.6
3302.5
e6/l
—
5
58
15
89
1.70
1.08
1.0
1.4
—
—
—
0
0
52
402
1.32
1.08
4.7
3.5
—
—
—
0
0
10
52
1.94
1.06
1.5
3.0
69.4
56.6
%
—
5
38
113
962
1.22
1.06
3.1
2.5
7.8
5.3
e6/l
0.80
103
853
87
721
1.24
1.05
1.9
1.6
—
—
—
0
0
398
4187
0.85
1.05
22.0
17.1
332.5
332.6
g/l
0.09
393
4163
72
587
1.26
1.01
2.7
2.3
107.2
133.7
ug/g
0.63
59
468
9
48
1.89
1.01
1.1
1.3
—
—
—
0
0
39
512
0.75
1.00
1.2
1.4
—
—
—
0
0
7
135
0.51
0.99
5.1
3.0
—
—
—
0
0
20
132
1.53
0.98
3.1
2.4
99.4
42.8
ug/min
0.61
12
77
12
69
1.75
0.97
1.2
1.6
—
—
—
0
0
68
556
1.25
0.94
2.0
1.5
—
—
—
0
0
9
52
1.74
0.92
2.4
2.6
—
—
—
0
0
10
55
1.83
0.92
2.1
1.7
31.7
32.9
pg
—
10
55
23
159
1.46
0.92
1.8
2.2
423.4
3316.3
u/l
—
6
61
44
341
1.31
0.92
1.7
1.4
—
—
—
0
0
39
297
1.33
0.92
1.3
1.3
—
44.3
—
0
15
24
168
1.45
0.91
1.5
1.6
—
—
—
0
0
6
29
2.08
0.89
1.2
1.2
—
—
—
0
0
22
311
0.70
0.89
1.7
1.4
—
—
—
0
0
8
42
1.92
0.89
1.3
1.8
—
—
—
0
0
11
64
1.73
0.86
1.1
1.2
—
—
—
0
0
226
2073
1.14
0.86
3.6
2.7
106.0
114.6
ug/l
0.35
207
1909
8
44
1.83
0.86
1.3
1.6
—
—
—
0
0
38
486
0.77
0.83
1.3
1.5
—
—
—
0
0
10
58
1.74
0.80
1.5
1.2
—
—
—
0
0
44
349
1.28
0.80
4.7
4.4
0.1
1.1
%
0.55
12
93
42
333
1.28
0.77
2.3
2.2
12.4
13.9
nmol/l
0.65
36
297
532
5197
1.21
0.75
12.4
10.1
27.4
26.1
u/l
0.57
512
5024
33
254
1.32
0.75
3.8
2.6
0.1
0.1
e6/l
0.57
33
244
23
167
1.39
0.74
1.6
1.2
—
—
—
0
0
7
38
1.85
0.73
1.0
2.8
—
—
—
0
0
64
537
1.21
0.73
1.6
1.6
—
—
—
0
0
45
365
1.25
0.70
1.1
1.1
—
—
—
0
0
41
329
1.26
0.70
2.5
2.4
—
17.5
—
0
12
5
93
0.53
0.67
1.6
1.5
—
—
—
0
0
5
93
0.53
0.67
1.6
1.4
—
—
—
0
0
5
95
0.52
0.67
1.6
1.5
—
—
—
0
0
44
360
1.24
0.65
7.4
7.6
—
—
—
0
0
436
4495
0.89
0.61
15.1
14.1
39.6
40.1
%
0.40
290
3317
42
345
1.23
0.60
1.1
1.2
165.4
123.0
iu/ml
0.29
14
146
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
8
52
1.55
0.59
1.4
1.3
369.9
362.0
pmol/l
—
8
41
149
1363
1.12
0.58
5.0
3.8
7.4
7.4
ph
0.80
41
255
6
35
1.72
0.58
1.0
1.0
—
—
—
0
0
11
73
1.52
0.56
1.1
1.1
—
—
—
0
0
48
404
1.20
0.56
1.5
1.4
—
—
—
0
0
8
122
0.65
0.55
1.1
1.2
—
—
—
0
0
96
858
1.14
0.54
3.0
2.9
2.4
2.4
mmol/l
0.86
79
748
9
60
1.51
0.54
1.4
3.8
—
—
—
0
0
97
868
1.14
0.54
4.5
3.5
40.7
256.6
ng/l
3.62
65
653
11
74
1.50
0.53
1.1
1.1
—
—
—
0
0
11
74
1.50
0.53
1.1
1.1
—
—
—
0
0
490
4789
1.13
0.52
4.9
4.3
1.4
1.5
mmol/l
1.10
453
4421
123
1345
0.89
0.52
1.5
1.4
—
—
—
0
0
9
64
1.41
0.51
3.9
2.8
—
—
—
0
0
492
4811
1.13
0.51
5.0
4.4
4.6
4.7
mmol/l
1.83
460
4466
11
75
1.48
0.51
1.5
1.2
—
—
—
0
0
9
65
1.39
0.50
3.9
2.8
4.1
4.0
mmol/l
—
9
65
9
65
1.39
0.50
3.9
2.8
105.0
105.9
mmol/l
—
9
65
10
67
1.50
0.50
1.0
1.1
1.7
1.5
g/l
—
10
60
19
145
1.32
0.49
1.5
2.2
275.1
281.6
ug/l
0.01
19
135
500
4897
1.13
0.49
5.3
4.8
2.7
2.8
mmol/l
1.39
460
4512
13
93
1.41
0.48
2.0
3.9
33.3
36.0
umol/l
0.25
13
82
118
1078
1.12
0.48
5.0
3.5
—
—
—
0
0
11
76
1.46
0.48
1.4
1.2
—
—
—
0
0
19
146
1.31
0.47
1.1
1.2
—
—
—
0
0
7
50
1.40
0.45
2.9
2.6
—
—
—
0
0
246
2340
1.09
0.44
4.8
3.5
0.0
0.0
estimate
0.00
57
447
7
51
1.38
0.44
1.1
1.2
—
—
—
0
0
126
1163
1.11
0.43
4.4
3.7
93.4
92.2
%
0.20
121
1138
5
32
1.57
0.42
1.0
1.1
—
5.3
—
0
11
8
57
1.41
0.42
2.8
1.7
15.5
16.1
ug/l
—
8
57
5
33
1.52
0.41
2.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
98
898
1.11
0.39
3.5
2.6
571.4
553.1
mosm/kgh2o
0.32
85
775
5
35
1.43
0.39
1.4
1.4
1.1
1.3
promille
—
5
28
59
524
1.14
0.39
2.6
2.7
12.3
8.0
umol/l
0.37
51
454
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
11
80
1.38
0.38
3.5
1.4
—
—
—
0
0
552
5455
1.15
0.38
26.0
19.5
90.7
90.9
fl
0.47
542
5380
552
5456
1.15
0.37
26.0
19.4
30.2
30.3
pg
0.34
542
5379
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
552
5457
1.14
0.36
26.1
19.5
4.5
4.5
e12/l
0.05
539
5315
11
81
1.36
0.36
1.1
1.1
—
—
—
0
0
552
5458
1.14
0.36
26.2
19.6
6.9
6.6
e9/l
1.81
540
5316
6
42
1.43
0.35
1.2
1.6
—
—
—
0
0
16
126
1.28
0.35
8.0
2.9
1.6
1.5
mg/l
0.36
16
114
136
1275
1.09
0.35
3.3
2.9
0.5
0.4
e6/l
0.02
112
949
114
1061
1.09
0.34
5.5
3.7
1.0
1.0
kg/l
0.16
19
139
552
5460
1.14
0.34
26.2
19.6
135.5
135.7
g/l
0.15
542
5381
16
127
1.27
0.34
1.8
1.2
—
2.6
—
0
19
551
5453
1.13
0.31
26.2
19.5
251.3
251.1
e9/l
0.02
539
5321
7
52
1.35
0.31
1.0
1.2
—
—
—
0
0
244
2349
1.07
0.30
6.1
4.8
0.0
0.0
estimate
0.00
59
445
7
55
1.28
0.30
1.3
1.1
—
—
—
0
0
53
478
1.12
0.30
1.6
1.5
—
—
—
0
0
12
94
1.28
0.28
8.3
2.6
2.4
2.8
mmol/l
—
6
62
10
128
0.78
0.27
7.6
2.8
—
—
—
0
0
11
86
1.28
0.26
3.3
2.4
—
—
—
0
0
5
72
0.69
0.26
1.0
2.1
2.8
60.4
u/ml
—
5
67
27
235
1.16
0.25
11.0
9.4
—
—
—
0
0
9
72
1.25
0.25
1.1
1.2
—
—
—
0
0
23
198
1.17
0.25
2.6
1.7
—
—
—
0
0
23
199
1.16
0.24
1.2
1.6
—
—
—
0
0
23
199
1.16
0.24
2.3
1.8
—
—
—
0
0
23
199
1.16
0.24
2.3
1.8
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
23
200
1.16
0.22
2.3
1.8
—
—
—
0
0
16
189
0.84
0.22
2.0
3.4
17.9
740.9
u/ml
—
10
160
5
40
1.25
0.22
3.8
3.5
—
—
—
0
0
10
79
1.27
0.22
1.5
1.1
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
5
42
1.19
0.21
1.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.8
—
0
5
5
43
1.16
0.21
1.4
1.1
—
—
—
0
0
17
197
0.86
0.20
1.1
1.1
—
—
—
0
0
6
50
1.20
0.19
2.0
1.2
—
—
—
0
0
329
3354
0.96
0.19
3.9
3.7
—
—
—
0
0
7
61
1.15
0.17
1.0
1.3
—
—
—
0
0
11
131
0.84
0.17
1.6
1.2
—
—
—
0
0
468
4630
1.05
0.17
4.6
3.9
1.4
1.3
mmol/l
2.37
430
4264
14
120
1.17
0.16
1.1
1.1
—
—
—
0
0
516
5119
1.06
0.16
17.6
12.4
—
—
—
0
0
28
306
0.91
0.15
4.5
2.5
—
—
—
0
0
9
83
1.09
0.14
5.8
2.1
—
—
—
0
0
124
1198
1.04
0.14
7.0
6.8
—
—
—
0
0
145
1407
1.04
0.14
3.8
3.0
48.7
118.8
e6/l
0.68
122
1077
46
489
0.94
0.13
3.0
4.2
3.7
22.2
ug/l
1.16
37
407
128
1319
0.96
0.12
4.4
3.2
—
—
—
0
0
242
2378
1.03
0.11
4.9
3.5
0.0
0.0
estimate
0.80
55
428
5
47
1.06
0.09
1.0
1.3
—
—
—
0
0
6
56
1.07
0.08
1.0
1.3
—
—
nmol/l
—
0
0
20
185
1.08
0.08
2.4
1.8
—
—
—
0
0
7
64
1.09
0.08
1.0
1.3
0.6
0.5
nmol/l
—
7
59
25
236
1.06
0.06
4.4
3.4
—
—
—
0
0
11
99
1.11
0.06
2.0
2.9
—
—
—
0
0
16
148
1.08
0.06
7.6
9.0
—
—
—
0
0
125
1272
0.98
0.06
1.7
1.7
1.5
1.4
mmol/l
0.85
106
1069
168
1660
1.02
0.05
4.1
3.5
86.3
95.1
e6/l
0.09
136
1169
45
439
1.03
0.03
2.0
1.7
—
—
—
0
0
140
1387
1.01
0.02
4.8
4.5
1.9
2.8
ug/l
0.97
130
1249
28
271
1.03
0.02
4.0
2.9
40.4
63.6
u/ml
0.40
28
263
31
301
1.03
0.02
1.2
1.2
—
—
—
0
0
24
248
0.97
0.02
1.5
1.8
—
—
—
0
0
15
157
0.95
0.01
2.9
1.8
—
—
—
0
0
126
1251
1.01
0.01
3.4
2.9
—
—
—
0
0
10
97
1.03
0.00
1.7
2.0
175.1
227.1
pmol/l
—
10
89
11
107
1.03
0.00
3.5
2.0
—
—
—
0
0
10
102
0.98
0.00
1.0
1.2
—
—
—
0
0
13
128
1.02
0.00
5.1
4.4
—
—
—
0
0
15
152
0.99
0.00
1.1
1.3
140.4
244.6
miu/ml
—
5
76
17
172
0.99
0.00
3.0
2.5
—
—
—
0
0
60
598
1.00
0.00
1.3
1.2
—
—
—
0
0
88
878
1.00
0.00
2.3
1.8
—
—
—
0
0
35
351
1.00
0.00
1.6
1.4
—
—
—
0
0
213
2135
1.00
0.00
11.4
9.1
0.0
0.0
e9/l
0.26
177
1769
0
5
0.00
0.00
0.0
1.0
—
34.3
—
0
5
0
5
0.00
0.00
0.0
8.6
—
0.5
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
190.4
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.9
—
0
6
5
58
0.86
0.00
2.2
1.8
—
—
—
0
0
5
51
0.98
0.00
2.0
2.4
—
—
—
0
0
6
61
0.98
0.00
3.7
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
7
76
0.92
0.00
2.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
40.2
—
0
6
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H8_EXT_NONINF and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXT_NONINF 1.437 [1.24, 1.66] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 2245 females with H8_EXT_NONINF died.

Males

Parameter HR [95% CI] p-value
H8_EXT_NONINF 1.369 [1.2, 1.56] < 0.001
Birth year 0.99 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 486 out of 2048 males with H8_EXT_NONINF died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXT_NONINF.

N-year risk Females Males
1 0.152% 0.252%
5 0.83% 1.636%
10 2.1% 4.116%
15 3.908% 7.577%
20 6.395% 13.316%

Relationships between endpoints

↥

Index endpoint: H8_EXT_NONINF – Acute otitis externa, noninfective

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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