otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
637 |
4. Check minimum number of eventsNone |
637 |
5. Include endpointsNone |
637 |
6. Filter based on genotype QC (FinnGen only) |
613 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H60
- Name in latin
- Otitis externa acuta non infectiosa
Similar endpoints
↥List of similar endpoints to
Acute otitis externa, noninfective
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4704 | 2439 | 2237 |
| Only index persons | 4262 | 2271 | 1991 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.06 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 45.65 | 45.04 |
| Only index persons | 44.12 | 44.57 | 43.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 613 | 364 | 249 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.11 |
| Median age at first event (years) | 49.93 | 49.69 | 50.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 637
- Matched controls
- 6370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
+∞
307.7
637
14
H60.3
ICD-10 Finland
Other infective otitis externa
39.7
191.1
120
37
H60.9
ICD-10 Finland
Otitis externa, unspecified
14.5
181.1
188
179
H60.8
ICD-10 Finland
Other otitis externa
29.4
156.6
108
44
UDC00
NOMESCO Finland
Ear microscopy
9.2
111.9
156
216
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
14.4
85.2
81
64
S02CA02
ATC
flumetasone and antiinfectives; otic
8.4
81.1
117
166
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
14.0
70.2
67
53
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
15.4
60.3
54
38
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
15.9
52.4
46
31
H65.3
ICD-10 Finland
Chronic mucoid otitis media
14.5
49.8
46
34
H70
ICPC
Otitis externa
12.0
49.0
51
46
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.1
48.0
163
493
H66.0
ICD-10 Finland
Acute suppurative otitis media
5.4
47.4
104
222
H65.0
ICD-10 Finland
Acute serous otitis media
15.0
41.1
37
26
H60
ICD-10 Finland
Otitis externa
5.8
37.4
73
139
H61.2
ICD-10 Finland
Impacted cerumen
5.6
36.0
73
144
H01
ICPC
Ear pain/earache
3.6
30.8
119
385
H04
ICPC
Ear discharge
6.8
30.3
49
77
J01MA02
ATC
ciprofloxacin; systemic
2.5
28.5
302
1677
Z97.4
ICD-10 Finland
Presence of external hearing-aid
5.3
27.7
59
121
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
8.1
26.2
36
47
H29
ICPC
Ear symptom/complaint other
3.4
26.0
108
364
H66.9
ICD-10 Finland
Otitis media, unspecified
4.4
26.0
69
170
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.9
25.6
148
605
J01DA01
ATC
[U] cefalexin
2.5
24.9
452
3130
DFF00
NOMESCO Finland
Pure tone audiometry
3.3
23.3
98
332
H13
ICPC
Plugged feeling ear
2.6
21.9
155
697
H60.1
ICD-10 Finland
Cellulitis of external ear
18.7
21.1
32
18
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
4.0
20.9
64
175
H92.0
ICD-10 Finland
Otalgia
4.0
20.1
60
161
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.5
18.7
138
629
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.9
17.9
54
146
H71
ICD-10 Finland
Cholesteatoma of middle ear
15.6
16.8
27
18
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
4.6
16.4
40
92
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
30.9
16.2
21
7
J01DA09
ATC
[U] cefadroxil
2.1
15.9
196
1102
DAX08
NOMESCO Finland
Fitting of hearing aid
3.7
15.8
51
145
H61.8
ICD-10 Finland
Other specified disorders of external ear
27.1
15.7
21
8
H65.2
ICD-10 Finland
Chronic serous otitis media
14.4
15.1
25
18
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
17.5
14.4
22
13
D07AC01
ATC
betamethasone; topical
1.9
13.3
244
1563
H60.0
ICD-10 Finland
Abscess of external ear
41.0
13.2
16
*
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
41.0
13.2
16
*
DC1AD
NOMESCO Finland
Temporalbone CT
17.1
13.1
20
12
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
12.9
207
1265
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
71.3
12.6
14
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
12.2
95
439
H81
ICPC
Excessive ear wax
2.2
12.1
118
599
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
13.0
11.2
19
15
DCD00
NOMESCO Finland
Myringoplasty
13.0
11.2
19
15
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.9
11.0
187
1154
J01DB01
ATC
cefalexin; oral
2.1
11.0
528
4458
Z3229
NOMESCO Finland
Other healthcare associate professional
2.6
10.9
64
259
TDA90
NOMESCO Finland
Removal wax from ear
9.0
10.3
21
24
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
10.1
127
707
C03CA01
ATC
furosemide; systemic
1.8
10.1
181
1133
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
10.1
338
2529
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
10.0
72
321
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
26.5
9.8
13
5
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
9.8
269
1902
D07XC01
ATC
betamethasone; topical
2.2
9.7
85
412
H02AB04
ATC
methylprednisolone; systemic
2.1
9.7
100
518
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.9
9.6
28
74
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
8.9
9.3
19
22
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
9.3
184
1183
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
9.1
127
732
H74.1
ICD-10 Finland
Adhesive middle ear disease
15.9
9.1
14
9
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
8.9
71
330
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
8.9
231
1599
R4135
NOMESCO Finland
Rehabilitation for hearing problems
5.0
8.9
19
39
J01MA12
ATC
levofloxacin; systemic
1.9
8.7
120
687
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
9.2
8.6
17
19
S02CA06
ATC
dexamethasone and antiinfectives; otic
9.2
8.6
17
19
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
6.5
8.5
21
33
H80.9
ICD-10 Finland
Otosclerosis, unspecified
9.6
8.3
16
17
DFF15
NOMESCO Finland
Speech audiometry
2.8
8.3
41
152
J02AC01
ATC
fluconazole; systemic
1.7
8.2
244
1741
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
8.2
126
747
D07AB08
ATC
desonide; topical
2.1
8.2
78
391
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
8.2
177
1162
R5140
NOMESCO Finland
Monitoring the use of the aid
2.1
8.1
78
392
I25.2
ICD-10 Finland
Old myocardial infarction
2.6
8.0
45
178
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
7.9
147
923
E66.8
ICD-10 Finland
Other obesity
2.8
7.9
40
150
K02.1
ICD-10 Finland
Caries of dentine
1.6
7.9
364
2885
SFA20
NOMESCO Finland
Two-surface restoration
1.6
7.8
363
2876
H70.1
ICD-10 Finland
Chronic mastoiditis
15.3
7.7
12
8
J01FA10
ATC
azithromycin; systemic
1.6
7.7
363
2882
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
7.7
142
889
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
7.6
439
3657
J01CA04
ATC
amoxicillin; systemic
1.8
7.5
512
4451
R5120
NOMESCO Finland
Preparation of an aid
3.4
7.5
26
78
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
81.0
7.4
8
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
81.0
7.4
8
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.0
7.4
88
479
J01FF01
ATC
clindamycin; systemic
1.7
7.3
173
1158
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
7.3
444
3727
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.7
7.3
167
1109
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.3
267
1992
SPAT1312
SPAT
General health counselling
1.6
7.3
191
1314
R06.0
ICD-10 Finland
Dyspnoea
1.7
7.2
167
1110
A46
ICD-10 Finland
Erysipelas
1.9
7.1
92
515
G47.3
ICD-10 Finland
Sleep apnoea
1.7
7.1
143
916
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
4.0
6.9
19
48
SFA30
NOMESCO Finland
Three-surface restoration
1.6
6.9
258
1927
D07CC01
ATC
betamethasone and antibiotics; topical
2.0
6.8
83
454
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
40.5
6.8
8
*
N03AX16
ATC
[U] pregabalin
1.7
6.8
144
935
H66
ICD-10 Finland
Suppurative and unspecified otitis media
4.0
6.8
19
49
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
6.7
79
427
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.6
6.7
204
1450
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
6.7
268
2030
SPAT1254
SPAT
Administration of medicine
1.9
6.7
93
533
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.5
6.6
22
64
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.4
6.6
46
202
J01FA01
ATC
erythromycin; systemic
1.9
6.6
84
467
SFA10
NOMESCO Finland
One-surface restoration
1.5
6.6
336
2679
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.1
6.6
27
90
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
6.6
151
1000
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
7.0
6.5
15
22
L04AA06
ATC
mycophenolic acid; systemic
5.4
6.5
18
34
D07BC01
ATC
betamethasone and antiseptics; topical
2.0
6.5
75
404
C01DA14
ATC
isosorbide mononitrate; oral
1.9
6.5
89
508
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
6.4
185
1295
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
6.4
57
278
L04AD01
ATC
ciclosporin; systemic
4.1
6.4
17
42
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
6.3
145
960
H02AB06
ATC
prednisolone; systemic
1.5
6.3
286
2219
H73.1
ICD-10 Finland
Chronic myringitis
+∞
6.3
6
*
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
27.0
6.2
8
*
D05BB02
ATC
acitretin; oral
3.7
6.2
19
52
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.2
193
1374
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
6.2
291
2269
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
6.2
131
848
SPAT1360
SPAT
Extensive global examination
2.4
6.2
42
183
E66.01
ICD-10 Finland
Obesity due to excess calories
2.1
6.1
60
304
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
6.1
330
2649
E000006, ,
ATC
2.2
6.1
48
223
R11
ICD-10 Finland
Nausea and vomiting
2.1
6.1
58
291
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
6.1
84
480
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
6.0
242
1822
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.9
6.0
17
44
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
3.1
6.0
25
84
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
115
636
1.99
9.28
5.0
4.4
31.99
32.11
%
0.04
69
430
226
1569
1.68
8.53
4.0
2.5
65.20
60.36
u/l
0.20
212
1460
46
187
2.57
7.76
2.0
1.8
—
—
—
0
0
213
1486
1.65
7.74
2.3
2.0
208.23
236.72
u/l
0.15
202
1404
258
1900
1.60
7.47
4.6
3.4
66.03
55.32
ng/l
0.12
184
1296
363
2931
1.55
6.82
5.3
4.5
6.79
6.71
mmol/l
0.23
336
2718
58
297
2.05
5.76
4.1
3.5
1.50
1.92
mmol/l
0.45
47
226
210
1547
1.53
5.74
3.9
3.8
8.31
8.73
mg/mmol
0.04
123
959
39
170
2.38
5.72
2.1
1.6
—
—
—
0
0
98
602
1.74
5.57
8.0
5.4
1.09
1.03
mmol/l
1.30
91
555
177
1276
1.54
5.27
2.7
2.6
5060.87
6863.79
umol/l
0.21
150
1117
97
613
1.69
4.97
7.8
6.7
—
—
—
0
0
113
744
1.63
4.94
1.8
1.9
—
—
—
0
0
168
1221
1.51
4.76
2.4
2.3
—
—
—
0
0
436
3809
1.46
4.61
5.0
4.1
11.96
11.73
mm/h
0.12
396
3515
448
3936
1.47
4.58
4.5
3.9
14.57
14.74
pmol/l
0.79
399
3571
280
2262
1.42
4.54
13.3
12.4
1.24
1.20
inr
0.33
80
665
294
2408
1.41
4.36
8.3
6.5
1.21
1.22
mmol/l
0.88
243
2069
125
875
1.53
4.18
1.8
1.7
1141.50
1188.84
nmol/l
0.27
98
664
122
852
1.53
4.12
1.3
1.3
2.31
11.13
u/ml
3.58
56
335
17
58
2.98
4.03
1.4
1.3
—
—
—
0
0
205
1593
1.42
4.03
3.5
3.1
7.37
7.58
mmol/l
0.26
171
1349
248
1995
1.40
3.99
2.2
1.9
99.44
95.89
pmol/l
0.53
143
1015
65
391
1.74
3.99
4.7
3.5
130.48
75.67
ng/l
1.59
48
356
409
4541
0.72
3.66
17.5
16.0
15.08
14.83
%
0.35
398
4464
266
2191
1.37
3.61
7.1
5.6
1.21
1.21
mmol/l
0.82
235
2003
31
151
2.11
3.57
1.4
1.6
—
—
—
0
0
123
886
1.48
3.57
1.3
1.3
24.81
35.41
iu/ml
0.41
39
295
28
131
2.19
3.56
2.2
1.5
—
—
—
0
0
56
335
1.74
3.52
1.6
1.6
—
—
—
0
0
292
2448
1.36
3.52
6.6
6.0
27.12
28.00
%
0.74
269
2310
19
75
2.58
3.49
1.5
1.3
—
—
—
0
0
29
140
2.12
3.43
2.8
3.7
1.10
1.11
ratio
—
6
17
135
1003
1.44
3.33
1.7
1.7
48624325.17
22512284.03
pmol/l
0.22
109
844
18
71
2.58
3.32
1.3
1.4
—
—
—
0
0
49
290
1.75
3.21
1.5
1.4
—
—
—
0
0
25
117
2.18
3.20
1.4
1.3
—
—
—
0
0
107
767
1.47
3.17
3.7
3.4
0.79
0.82
mmol/l
1.27
99
724
513
4736
1.43
3.15
6.8
5.6
40.79
39.79
mmol/mol
1.49
462
4408
436
3929
1.35
3.04
8.6
7.5
83.30
77.57
u/l
0.56
408
3687
13
45
2.93
3.04
1.1
1.0
0.18
0.71
u/ml
—
5
11
512
4741
1.41
2.95
5.5
4.7
1.80
1.89
mu/l
0.80
463
4341
21
95
2.25
2.93
8.5
7.4
699.40
147.79
iu/ml
—
5
14
17
70
2.47
2.90
1.3
1.4
—
—
—
0
0
17
70
2.47
2.90
1.3
1.4
—
—
—
0
0
17
70
2.47
2.90
1.3
1.4
—
—
—
0
0
308
2656
1.31
2.86
6.9
6.3
10.43
10.97
umol/l
0.53
292
2523
17
71
2.43
2.82
1.3
1.4
—
—
—
0
0
283
2417
1.31
2.81
6.5
5.7
58.28
57.05
%
1.02
259
2285
27
138
2.00
2.79
1.4
1.5
213.08
283.99
ug/g
1.07
12
85
11
34
3.27
2.73
1.2
1.0
—
—
—
0
0
67
454
1.53
2.61
2.0
2.0
339.15
371.88
nmol/l
0.73
59
423
11
36
3.09
2.57
2.2
1.4
72.64
72.28
umol/l
0.03
11
36
8
20
4.04
2.57
1.0
1.1
—
—
—
0
0
59
390
1.57
2.57
2.7
3.1
66.10
67.19
g/l
0.49
49
358
31
172
1.84
2.55
4.9
4.1
1.30
1.33
mmol/l
0.07
31
166
247
2098
1.29
2.48
5.6
4.8
35.42
35.81
g/l
0.52
230
1957
63
428
1.52
2.44
4.4
3.5
2.58
1.91
mmol/l
0.40
53
347
5
8
6.29
2.37
1.0
1.4
—
—
—
0
0
5
8
6.29
2.37
1.0
1.1
—
—
—
0
0
95
704
1.41
2.37
3.5
2.2
2.43
2.36
g/l
0.60
89
656
7
17
4.15
2.36
1.1
1.1
1343.86
1511.76
miu/ml
—
7
17
16
71
2.29
2.36
1.3
1.4
—
—
—
0
0
11
39
2.85
2.35
1.0
1.1
—
—
—
0
0
11
40
2.78
2.28
1.0
1.1
—
—
—
0
0
147
1180
1.32
2.22
1.3
1.2
0.94
1.86
u/ml
1.01
43
324
558
5308
1.41
2.19
19.9
15.2
3.97
3.96
mmol/l
0.34
538
5153
12
48
2.53
2.19
1.2
1.3
—
—
—
0
0
557
5297
1.41
2.19
20.1
15.1
139.64
139.66
mmol/l
0.07
540
5149
89
664
1.40
2.15
3.6
2.2
22.09
22.94
%
0.25
79
576
15
68
2.23
2.12
1.2
1.4
0.22
0.41
nmol/l
—
10
55
153
1243
1.30
2.11
2.6
2.0
3.03
3.03
mg/l
0.01
133
1062
19
96
2.01
2.07
2.1
1.2
106.97
105.38
u/ml
—
6
21
330
2948
1.25
2.06
9.8
9.3
4.15
4.05
e9/l
0.42
296
2608
240
2071
1.25
2.03
2.6
2.2
75.24
76.21
nmol/l
0.23
205
1855
17
83
2.08
2.03
1.2
1.1
3.20
3.17
u/ml
—
7
42
10
38
2.66
2.01
1.1
1.1
—
—
—
0
0
6
16
3.77
1.94
1.0
1.1
—
—
—
0
0
167
1390
1.27
1.90
3.8
2.9
1175.74
1081.84
ng/l
0.16
146
1181
99
770
1.34
1.86
3.6
2.2
13.32
13.22
umol/l
0.05
92
719
6
17
3.55
1.84
1.0
1.1
—
—
—
0
0
7
23
3.07
1.80
1.9
1.6
—
—
—
0
0
195
1665
1.25
1.77
3.6
3.4
2.33
2.36
mmol/l
1.68
164
1471
44
299
1.51
1.75
2.3
3.4
4.26
4.56
pmol/l
1.28
39
262
138
1134
1.28
1.73
1.6
1.5
20.74
21.21
nmol/l
0.12
110
966
379
3478
1.22
1.70
3.8
3.1
56.54
45.73
u/l
0.68
350
3266
19
105
1.83
1.64
1.9
1.2
—
—
—
0
0
55
397
1.42
1.63
2.3
2.4
57.78
67.92
ml/min/173m2
1.07
23
154
10
42
2.40
1.62
1.1
1.1
—
—
—
0
0
17
91
1.89
1.62
3.4
3.8
58.18
57.92
%
0.03
17
91
525
5003
1.28
1.60
5.3
4.4
6.13
5.92
mmol/l
1.98
468
4566
135
1121
1.26
1.56
1.7
1.7
0.96
1.19
mg/l
1.10
111
848
543
5202
1.30
1.54
17.8
13.2
19.33
23.01
mg/l
2.22
452
4082
8
33
2.44
1.54
1.0
1.2
—
—
—
0
0
269
2404
1.21
1.54
2.6
2.5
—
—
—
0
0
5
15
3.35
1.52
1.6
1.1
—
—
—
0
0
12
59
2.05
1.44
1.6
1.5
75.00
63.66
%
—
6
47
6
22
2.74
1.43
2.0
3.2
44983.33
38141.14
ug/l
—
6
22
22
134
1.66
1.41
1.4
1.4
—
—
—
0
0
16
89
1.82
1.38
3.3
3.5
4.14
4.29
e9/l
0.10
16
89
6
23
2.62
1.37
1.2
1.6
—
—
—
0
0
358
3308
1.19
1.36
3.1
3.1
—
—
—
0
0
11
54
2.06
1.33
1.0
1.1
—
—
—
0
0
27
178
1.54
1.28
1.2
2.1
—
—
—
0
0
27
178
1.54
1.28
1.2
2.1
7.60
7.44
g/l
0.13
22
163
21
131
1.62
1.25
1.3
1.2
—
—
—
0
0
22
139
1.60
1.24
2.9
2.2
99.41
43.41
ug/min
0.60
12
81
8
36
2.24
1.24
1.0
3.3
—
—
—
0
0
156
1357
1.20
1.16
5.4
3.7
0.00
0.01
estimate
0.69
59
465
358
3339
1.16
1.13
5.3
4.2
8.60
3302.48
e6/l
—
5
58
7
30
2.35
1.12
1.3
1.3
—
—
—
0
0
7
31
2.27
1.10
1.0
1.5
—
275.00
—
0
6
67
536
1.28
1.08
7.1
7.2
1.88
1.14
mmol/l
0.71
52
442
10
52
1.94
1.06
1.0
1.1
—
—
—
0
0
17
107
1.60
1.00
1.5
1.2
274.50
255.45
u/ml
—
10
62
25
173
1.46
0.99
1.7
2.2
2503.79
2925.79
u/l
—
7
73
71
861
0.80
0.98
3.0
2.8
0.66
0.75
ug/l
0.50
48
546
17
109
1.57
0.94
1.5
1.2
—
—
—
0
0
7
37
1.90
0.94
1.4
1.8
10.27
7.38
mmol/l
—
7
37
6
27
2.23
0.93
1.0
1.9
1.00
1.08
nmol/l
—
6
20
6
28
2.15
0.91
1.0
1.3
—
—
—
0
0
35
262
1.36
0.91
1.1
1.0
—
—
—
0
0
508
4905
1.18
0.90
14.9
12.2
81.98
82.50
ml/min/173m2
0.20
439
4028
36
272
1.34
0.89
1.5
1.6
—
—
—
0
0
22
152
1.46
0.89
2.2
2.4
1.04
1.08
g/l
0.02
17
135
568
5541
1.23
0.88
12.3
10.1
27.25
26.03
u/l
0.52
537
5355
13
80
1.64
0.85
5.0
3.1
—
3918.14
—
0
7
14
88
1.60
0.85
4.4
1.8
—
—
—
0
0
6
32
1.88
0.82
1.0
1.2
81.17
156.14
pmol/l
—
6
32
30
224
1.36
0.81
1.5
2.1
40.09
38.43
u/l
0.17
25
201
46
369
1.27
0.77
1.1
1.2
147.25
130.55
iu/ml
0.11
16
155
525
5106
1.16
0.73
5.0
4.3
1.44
1.48
mmol/l
1.30
477
4722
5
25
2.01
0.73
5.4
2.0
—
—
—
0
0
527
5130
1.16
0.70
5.0
4.4
4.58
4.71
mmol/l
2.33
484
4771
115
1020
1.16
0.70
3.1
2.4
7.56
5.25
e6/l
0.72
107
927
34
267
1.29
0.68
3.7
2.6
0.09
0.15
e6/l
0.62
34
257
535
5217
1.16
0.68
5.3
4.8
2.70
2.79
mmol/l
1.81
485
4819
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
12
78
1.55
0.66
1.0
1.1
—
—
—
0
0
238
2222
1.11
0.64
3.6
2.7
105.69
116.30
ug/l
0.46
216
2051
23
172
1.35
0.64
2.3
1.8
—
—
—
0
0
5
29
1.73
0.64
1.4
1.2
—
—
—
0
0
5
29
1.73
0.64
1.4
1.2
—
—
—
0
0
5
29
1.73
0.64
1.2
1.7
—
—
—
0
0
5
29
1.73
0.64
1.2
1.7
—
—
—
0
0
43
353
1.23
0.62
2.2
2.2
12.47
13.76
nmol/l
0.52
37
320
0
21
0.00
0.60
0.0
2.5
—
908.43
—
0
21
11
72
1.54
0.59
1.0
1.1
1.65
1.47
g/l
1.48
11
65
22
167
1.33
0.57
1.5
1.4
—
—
—
0
0
6
39
1.54
0.53
1.0
1.1
—
—
—
0
0
19
143
1.34
0.53
1.8
1.2
—
2.66
—
0
7
61
529
1.17
0.52
2.2
1.9
—
—
—
0
0
18
135
1.34
0.51
1.9
1.2
—
2.63
—
0
18
14
101
1.39
0.50
2.0
1.5
—
—
—
0
0
60
522
1.16
0.49
1.8
1.9
—
—
—
0
0
7
48
1.46
0.47
2.9
2.4
—
—
—
0
0
589
5814
1.17
0.47
25.5
19.6
40.03
40.25
%
0.33
548
5468
8
121
0.66
0.45
1.5
1.5
—
—
—
0
0
8
121
0.66
0.45
1.5
1.4
—
—
—
0
0
8
121
0.66
0.45
1.5
1.4
—
—
—
0
0
8
121
0.66
0.45
1.5
1.5
—
—
—
0
0
208
1961
1.09
0.45
5.0
3.6
—
—
—
0
0
182
1707
1.09
0.44
3.3
3.3
31.96
31.23
u/l
0.09
171
1626
589
5817
1.17
0.44
25.5
19.6
4.50
4.50
e12/l
0.04
573
5664
59
519
1.15
0.43
1.7
1.8
—
—
—
0
0
9
129
0.69
0.43
1.6
1.5
—
—
—
0
0
5
31
1.62
0.43
1.0
1.6
—
25.13
—
0
8
101
922
1.11
0.42
3.0
3.0
2.43
2.45
mmol/l
0.72
84
803
589
5820
1.16
0.42
25.6
19.7
135.49
135.55
g/l
0.03
577
5732
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.0
1.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
17
0.00
0.40
0.0
1.0
—
128.47
—
0
17
0
17
0.00
0.40
0.0
1.0
—
104.09
—
0
11
0
17
0.00
0.40
0.0
1.0
—
95.27
—
0
11
20
159
1.27
0.40
3.2
2.8
—
—
—
0
0
8
60
1.34
0.40
2.8
1.8
15.46
16.56
ug/l
—
8
60
588
5813
1.15
0.39
25.5
19.6
250.73
251.62
e9/l
0.13
574
5671
9
66
1.37
0.38
3.9
2.8
105.00
105.79
mmol/l
—
9
66
17
134
1.28
0.37
1.4
1.3
—
—
—
0
0
6
43
1.40
0.35
1.2
1.0
—
—
—
0
0
19
154
1.24
0.34
1.1
1.1
—
—
—
0
0
19
154
1.24
0.34
1.1
1.1
—
—
—
0
0
6
86
0.69
0.33
1.0
1.5
—
—
—
0
0
6
87
0.69
0.33
1.0
1.3
—
—
—
0
0
6
87
0.69
0.33
1.0
1.3
—
—
—
0
0
65
589
1.12
0.33
2.2
2.0
—
—
—
0
0
13
101
1.29
0.32
2.0
3.8
33.31
35.59
umol/l
0.22
13
93
13
101
1.29
0.32
2.2
1.7
—
—
—
0
0
27
315
0.85
0.31
1.9
1.8
—
—
—
0
0
7
55
1.28
0.30
6.0
2.7
29.29
49.39
u/ml
—
7
55
502
4941
1.08
0.30
4.6
3.9
1.39
1.29
mmol/l
2.13
451
4550
14
174
0.80
0.30
1.8
1.4
—
—
—
0
0
71
651
1.10
0.30
1.6
1.7
1.61
1.45
%
0.89
59
572
187
1787
1.07
0.29
4.3
2.9
—
—
—
0
0
55
499
1.11
0.28
3.3
3.0
—
—
—
0
0
17
205
0.82
0.28
2.0
3.5
16.55
675.86
u/ml
1.01
11
176
61
557
1.11
0.28
2.6
2.7
11.92
8.43
umol/l
0.30
53
488
9
120
0.75
0.27
1.3
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
131
1.23
0.27
3.2
2.7
0.28
0.34
u/ml
—
10
71
8
66
1.21
0.27
1.1
1.1
—
—
—
0
0
132
1257
1.06
0.23
4.3
3.7
93.94
92.25
%
0.34
127
1231
5
40
1.25
0.22
1.4
1.4
1.06
1.22
promille
—
5
32
44
482
0.91
0.22
1.8
1.7
—
—
—
0
0
10
124
0.80
0.21
1.1
2.4
0.00
0.00
g/l
—
10
116
16
135
1.19
0.21
8.0
2.9
1.62
1.44
mg/l
0.45
16
122
72
769
0.93
0.21
2.9
2.7
4.75
2.77
e6/l
0.47
43
413
0
10
0.00
0.21
0.0
1.1
—
40.86
—
0
5
0
12
0.00
0.21
0.0
2.1
—
2.76
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
130
1359
0.95
0.21
1.7
1.7
1.50
1.39
mmol/l
0.85
109
1144
16
136
1.18
0.20
1.3
1.2
—
—
—
0
0
13
108
1.21
0.20
1.5
1.6
—
—
—
0
0
6
50
1.20
0.19
1.0
1.6
—
—
—
0
0
97
922
1.06
0.19
4.5
3.6
40.66
295.11
ng/l
4.00
65
693
10
81
1.24
0.19
1.3
1.1
—
—
—
0
0
6
53
1.13
0.18
1.2
1.6
—
—
—
0
0
6
53
1.13
0.18
1.2
1.6
—
—
—
0
0
6
53
1.13
0.18
1.2
1.6
—
—
—
0
0
113
1181
0.95
0.18
3.6
4.1
20.75
21.15
%
0.11
53
532
7
62
1.13
0.17
1.0
1.2
—
—
—
0
0
10
82
1.22
0.17
1.3
1.1
—
—
—
0
0
5
68
0.73
0.17
1.0
1.5
—
—
—
0
0
80
842
0.94
0.17
1.5
1.4
—
—
—
0
0
151
1460
1.04
0.16
4.8
4.6
1.95
2.78
ug/l
0.92
138
1316
86
821
1.05
0.15
2.6
2.6
1.74
0.97
e6/l
0.89
58
463
20
223
0.89
0.14
1.7
1.5
—
—
—
0
0
102
982
1.05
0.13
1.6
1.5
—
—
—
0
0
255
2503
1.03
0.13
4.7
3.5
0.00
0.00
estimate
0.50
64
501
10
85
1.18
0.12
1.6
1.5
—
—
—
0
0
11
126
0.87
0.11
1.1
2.4
0.00
0.00
g/l
-0.00
11
117
18
198
0.91
0.11
2.5
1.8
—
—
—
0
0
139
1356
1.03
0.10
3.3
2.9
0.44
0.45
e6/l
0.02
115
1020
12
135
0.89
0.10
1.1
2.3
0.00
0.04
g/l
0.50
12
126
5
45
1.11
0.10
1.2
1.1
—
—
—
0
0
5
45
1.11
0.10
1.2
1.1
—
—
—
0
0
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
250
2535
0.98
0.09
4.8
3.5
0.00
0.01
estimate
0.80
57
455
50
522
0.95
0.09
2.9
4.3
3.63
20.91
ug/l
1.16
38
435
6
54
1.11
0.09
1.3
2.1
13.57
13.01
%
—
6
54
6
58
1.03
0.08
2.5
4.1
—
—
—
0
0
13
117
1.11
0.08
5.5
1.8
—
—
—
0
0
7
66
1.06
0.08
1.0
1.0
—
—
—
0
0
7
68
1.03
0.08
1.0
1.3
0.56
0.56
nmol/l
—
7
63
7
85
0.82
0.07
1.0
1.7
—
—
—
0
0
9
103
0.87
0.06
1.4
1.4
—
—
—
0
0
14
150
0.93
0.04
1.0
1.1
—
5.76
—
0
20
151
1492
1.02
0.04
3.7
3.0
48.11
112.76
e6/l
0.66
125
1146
15
160
0.94
0.04
1.1
1.3
140.40
254.10
miu/ml
—
5
78
114
1126
1.02
0.03
5.5
3.7
1.02
1.02
kg/l
0.22
19
151
13
122
1.07
0.02
1.3
1.6
—
—
—
0
0
252
2506
1.01
0.02
6.0
4.8
0.00
0.00
estimate
-0.00
61
471
15
157
0.95
0.01
1.7
1.2
—
—
—
0
0
13
136
0.95
0.00
1.2
1.1
—
—
—
0
0
11
115
0.96
0.00
1.3
1.8
—
—
—
0
0
10
104
0.96
0.00
1.7
2.0
175.10
222.08
pmol/l
—
10
96
24
245
0.98
0.00
1.8
1.7
—
—
—
0
0
16
158
1.01
0.00
1.3
1.5
—
—
—
0
0
28
278
1.01
0.00
1.1
1.3
—
—
—
0
0
7
69
1.01
0.00
1.4
1.6
—
—
—
0
0
9
91
0.99
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
5
52
0.96
-0.00
2.0
1.4
4.10
2.98
ug/l
—
5
45
6
63
0.95
-0.00
1.5
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
40.56
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
-0.00
1.0
1.1
—
14.07
—
0
6
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
-0.00
2.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
121.57
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_NONINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_NONINF | 1.437 [1.24, 1.66] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 2245 females with H8_EXT_NONINF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_NONINF | 1.369 [1.2, 1.56] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 486 out of 2048 males with H8_EXT_NONINF died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_NONINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.152% | 0.252% |
| 5 | 0.83% | 1.636% |
| 10 | 2.1% | 4.116% |
| 15 | 3.908% | 7.577% |
| 20 | 6.395% | 13.316% |
Relationships between endpoints
↥Index endpoint: H8_EXT_NONINF – Acute otitis externa, noninfective
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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