obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
809 |
4. Check minimum number of eventsNone |
809 |
5. Include endpointsNone |
809 |
6. Filter based on genotype QC (FinnGen only) |
778 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L81
- Name in latin
- Alia hyperpigmentatio melaninalis
Similar endpoints
↥List of similar endpoints to
Other melanin hyperpigmentation
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5087 | 3489 | 1584 |
| Only index persons | 4808 | 3344 | 1464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.04 |
| Only index persons | 0.10 | 0.12 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 65.20 | 65.37 | 65.10 |
| Only index persons | 65.53 | 65.39 | 65.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 778 | 518 | 260 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.12 |
| Median age at first event (years) | 65.00 | 63.30 | 68.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 809
- Matched controls
- 8090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
16.9
307.7
358
362
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
4503599627370496.0
307.7
807
7
L57.0
ICD-10 Finland
Actinic keratosis
9.4
208.1
336
571
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
14.9
122.8
115
89
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
7.6
108.1
174
280
XQ845
NOMESCO Finland
Dermatoscopy
17.6
95.4
80
50
XQ848
NOMESCO Finland
Dermatological photography
12.7
94.0
96
85
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
35.3
88.0
56
17
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
11.1
86.9
97
98
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.6
82.4
186
412
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.4
74.8
81
78
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.0
73.5
288
976
L82
ICD-10 Finland
Seborrhoeic keratosis
4.0
70.0
263
862
ZXC50
NOMESCO Finland
Cryotherapy
8.6
61.9
83
106
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
7.9
44.2
63
86
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
7.1
44.0
69
105
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
6.0
43.0
80
145
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
9.4
42.3
52
59
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.1
40.4
56
74
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
5.4
39.4
82
165
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
4.1
39.3
122
339
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.2
36.7
106
279
TQW99
NOMESCO Finland
Other minor procedure on skin
4.6
35.0
90
216
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
52.5
33.8
40
8
D06BB10
ATC
imiquimod; topical
4.4
32.4
87
216
ZXC15
NOMESCO Finland
Use of photodynamic technique
9.3
31.8
39
44
127
Kela drug reimbursment
Transplant complication
12.4
30.0
30
25
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
7.0
26.5
41
61
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
8.3
26.2
35
44
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.0
24.2
28
29
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.1
22.8
49
101
L04AD01
ATC
ciclosporin; systemic
7.7
22.6
32
43
L04AA01
ATC
[U] ciclosporin
8.8
22.0
28
33
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
8.0
21.8
30
39
SPAT1153
SPAT
Removal of sutures
2.1
21.5
320
1936
L04AA06
ATC
mycophenolic acid; systemic
8.1
21.4
29
37
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
6.5
21.2
35
56
TQW80
NOMESCO Finland
Local dermatologic skincare
6.4
20.8
35
57
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
8.4
19.7
26
32
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
18.3
19.7
30
17
ZXC20
NOMESCO Finland
Use of chemical agents
5.2
19.2
40
80
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
20.7
19.2
28
14
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
4.3
19.1
50
121
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
4.6
18.0
43
97
D06BX02
ATC
ingenol mebutate; topical
6.7
17.6
28
43
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
4.4
17.3
44
104
S18
ICPC
Laceration/cut
1.9
17.3
410
2851
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
3.0
16.9
79
282
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
12.5
16.4
29
24
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
15.9
174
922
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
16.9
14.8
23
14
S29
ICPC
Skin symptom/complaint other
2.0
14.4
174
955
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
24.3
13.8
19
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
34.7
13.5
17
5
L81.1
ICD-10 Finland
Chloasma
34.7
13.5
17
5
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
5.7
13.0
24
43
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
9.9
12.8
25
26
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.2
12.8
26
51
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
4.9
12.7
28
59
Z94.0
ICD-10 Finland
Kidney transplant status
15.7
12.7
20
13
E0000UV, ,
ATC
1.7
12.5
335
2346
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
5.0
11.7
25
51
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.0
11.7
25
51
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
5.8
11.0
20
35
A02BC05
ATC
esomeprazole; systemic
1.7
11.0
348
2527
ZZR00
NOMESCO Finland
Flap of skin
4.2
10.9
29
71
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
16.3
10.4
16
10
S21
ICPC
Skin texture symptom/complaint
2.0
10.0
128
710
SPAT1301
SPAT
No procedures
1.7
9.9
275
1917
L04AX01
ATC
azathioprine; systemic
3.2
9.9
38
121
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.8
190
1201
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
9.4
100
519
-, ,
ICD-10 Finland
3.7
9.3
29
80
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
13.9
9.2
15
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
9.1
108
584
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
9.2
9.1
18
20
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
24.3
8.9
12
5
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
8.1
8.9
19
24
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
2.7
8.8
47
180
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.8
276
1971
S08
ICPC
Skin colour change
2.5
8.7
54
223
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
8.7
376
2892
L91.0
ICD-10 Finland
Hypertrophic scar
16.5
8.6
13
8
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
8.5
531
4427
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
27.8
8.5
11
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
8.3
288
2101
E000006, ,
ATC
2.3
8.3
65
299
SPAT1325
SPAT
Vaccination
1.6
8.2
289
2113
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
8.2
41
152
A98
ICPC
Health maint/preventive medicine
2.7
8.2
773
7195
D03.5
ICD-10 Finland
Melanoma in situ of trunk
11.8
8.1
14
12
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
33.7
8.1
10
*
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
33.7
8.1
10
*
SPAT1260
SPAT
Consultation of another employee
1.8
8.0
147
910
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
7.9
247
1756
D07AD01
ATC
clobetasol; topical
1.8
7.9
128
765
A12AA04
ATC
calcium carbonate; oral
6.2
7.9
20
33
S82
ICPC
Naevus/mole
1.8
7.8
114
659
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
7.8
120
706
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
15.2
7.7
12
8
4056, ,
NOMESCO Finland
45.4
7.7
9
*
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
12.0
7.6
13
11
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
9.0
7.6
15
17
EMAK, ,
NOMESCO Finland
2.9
7.6
34
119
WX704
NOMESCO Finland
Intubation
2.1
7.5
70
346
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
80.8
7.4
8
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.4
160
1035
B07.9
ICD-10 Finland
Verruca simplex
3.2
7.3
29
94
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
7.3
475
3929
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
11.0
7.3
13
12
137
Kela drug reimbursment
Uraemia requiring dialysis
11.0
7.3
13
12
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.2
7.3
63
302
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
15.9
7.2
11
7
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.2
240
1725
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.5
7.1
262
1923
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.7
7.1
38
146
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
2.9
7.0
32
113
E000001, ,
ATC
1.7
7.0
146
935
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
13.9
6.9
11
8
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.3
6.9
50
223
J01DB01
ATC
cefalexin; oral
1.6
6.9
631
5582
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.9
6.8
89
497
L81.9
ICD-10 Finland
Disorder of pigmentation, unspecified
40.4
6.8
8
*
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
7.3
6.7
15
21
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
6.7
67
340
TQW40, ,
SPAT
2.1
6.7
64
320
Z3231
NOMESCO Finland
Registered nurse
1.6
6.7
214
1522
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
6.6
209
1481
KMAK, ,
NOMESCO Finland
1.5
6.6
361
2867
ZZA00
NOMESCO Finland
Split skin graft
3.1
6.6
27
90
L04AD02
ATC
tacrolimus; systemic
10.1
6.5
12
12
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
10.1
6.5
12
12
L14
ICPC
Leg/thigh symptom/complaint
2.0
6.5
73
386
H13
ICPC
Plugged feeling ear
1.6
6.5
160
1069
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
2.6
6.4
35
136
SPAT1312
SPAT
General health counselling
1.5
6.4
236
1728
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
3.1
6.3
26
87
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.3
525
4503
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
+∞
6.3
6
*
L01BB01, ,
ATC
26.9
6.2
8
*
L85.3
ICD-10 Finland
Xerosis cutis
7.1
6.2
14
20
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.1
6.2
14
20
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
3.7
6.2
19
52
D18.0
ICD-10 Finland
Haemangioma, any site
3.3
6.2
23
72
ZXA00
NOMESCO Finland
Right side
1.5
6.1
227
1661
K59.01
ICD-10 Finland
Constipation outlet obstruction type
4.2
6.1
16
39
B35.3
ICD-10 Finland
Tinea pedis
2.6
6.1
34
134
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.1
142
935
L71.8
ICD-10 Finland
Other rosacea
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
407
2870
1.84
15.99
2.3
2.2
80.15
79.41
nmol/l
0.19
365
2520
673
5721
2.05
13.13
19.8
17.7
14.33
15.23
%
5.65
663
5613
632
5317
1.86
11.91
7.9
7.3
75.66
78.77
u/l
1.46
595
4955
777
7100
3.39
11.55
11.9
10.5
23.97
24.55
u/l
0.47
750
6820
490
3853
1.69
11.54
9.2
8.8
3.81
4.14
e9/l
2.83
441
3373
433
3308
1.66
11.29
5.1
3.9
0.00
0.00
estimate
0.74
90
661
458
3575
1.65
10.77
7.6
6.2
1.22
1.22
mmol/l
0.20
396
3031
348
2546
1.64
10.52
5.2
4.1
—
—
—
0
0
430
3324
1.63
10.35
6.5
5.3
0.00
0.00
estimate
-0.00
86
603
433
3359
1.62
10.23
5.1
3.9
0.00
0.01
estimate
0.50
82
595
787
7329
3.71
9.63
25.0
21.6
242.61
249.23
e9/l
2.25
770
7111
787
7329
3.71
9.63
25.0
21.6
39.64
39.54
%
0.14
694
6758
787
7332
3.70
9.56
25.0
21.6
4.43
4.42
e12/l
0.16
769
7093
787
7334
3.69
9.51
25.1
21.7
134.10
133.25
g/l
1.02
779
7197
420
3271
1.59
9.48
6.4
5.5
1.22
1.21
mmol/l
0.46
389
2971
597
5076
1.67
9.24
5.2
4.1
12.12
13.39
mm/h
1.30
558
4641
28
76
3.78
9.22
1.7
1.4
—
—
—
0
0
763
7022
2.52
8.98
20.0
17.2
3.98
3.97
mmol/l
0.14
744
6816
218
1473
1.66
8.69
5.4
4.2
1.01
1.02
kg/l
0.46
18
216
740
6742
2.14
8.65
5.9
5.1
2.64
2.71
mmol/l
1.65
679
6119
696
6250
1.81
7.94
5.8
4.9
1.96
1.95
mu/l
0.17
644
5635
758
7007
2.30
7.93
19.7
17.0
139.82
139.67
mmol/l
0.89
739
6813
699
6288
1.82
7.88
6.6
6.0
39.12
40.20
mmol/mol
3.28
654
5762
723
6583
1.92
7.69
5.2
4.6
4.59
4.66
mmol/l
1.18
670
6016
724
6607
1.91
7.47
5.4
4.8
5.80
5.98
mmol/l
4.83
660
5938
384
3041
1.50
7.34
5.4
4.3
35.88
35.22
g/l
1.62
349
2814
250
1810
1.55
7.27
5.7
4.1
0.00
0.01
estimate
0.50
82
581
140
881
1.71
7.18
6.6
4.2
1.01
1.03
mmol/l
0.37
131
798
761
7089
2.24
7.08
20.1
17.4
81.61
76.80
umol/l
2.42
761
7089
536
4575
1.51
6.90
5.7
4.7
4321.14
3279.24
e6/l
—
7
74
597
5216
1.55
6.87
4.8
4.0
14.93
14.97
pmol/l
0.12
547
4672
47
205
2.37
6.80
1.3
1.2
0.55
1.99
u/ml
—
6
14
722
6624
1.84
6.74
16.3
14.4
22.13
24.39
mg/l
1.10
576
5255
392
3154
1.47
6.72
7.3
5.6
27.40
27.28
%
0.08
367
2942
29
101
2.94
6.53
8.6
4.9
98.20
637.64
iu/ml
—
5
14
712
6530
1.75
6.32
5.0
4.5
1.55
1.51
mmol/l
1.64
649
5911
383
3104
1.44
6.12
7.3
5.4
56.77
57.68
%
0.82
359
2899
97
576
1.78
6.08
4.2
3.1
97.16
81.37
ng/l
0.90
89
499
691
6306
1.66
6.01
4.5
4.0
1.20
1.27
mmol/l
2.71
624
5661
345
2751
1.44
5.98
3.2
2.6
108.43
126.60
ug/l
1.18
314
2484
90
529
1.79
5.83
2.6
2.6
64.64
62.77
ml/min/173m2
0.18
44
221
310
2434
1.44
5.79
3.3
3.4
2.34
2.36
mmol/l
1.05
276
2134
46
889
0.49
5.44
4.8
4.7
35.33
33.29
%
0.49
33
577
278
2160
1.44
5.41
3.0
2.4
58.77
62.33
u/l
0.51
249
1975
201
1472
1.49
5.31
3.5
2.4
3.98
6.37
e6/l
2.19
185
1340
405
3372
1.40
5.29
17.5
15.7
1.21
1.28
inr
0.93
122
961
251
1925
1.44
5.21
4.1
3.0
0.27
0.54
e6/l
1.90
200
1462
271
2110
1.43
5.17
2.4
2.1
168.29
207.78
u/l
0.52
249
1979
34
147
2.37
5.07
3.7
3.0
1.77
1.70
mg/l
0.15
29
132
469
4047
1.38
4.72
5.0
4.5
6.54
6.73
mmol/l
1.38
451
3787
114
757
1.59
4.69
2.4
2.5
6.21
8.21
umol/l
1.25
100
653
427
3637
1.37
4.62
6.1
6.0
11.84
11.32
umol/l
0.58
402
3448
145
1032
1.49
4.35
1.9
1.8
30.51
29.47
s
0.99
139
998
238
1858
1.40
4.35
1.7
1.6
1.25
1.33
mmol/l
1.01
187
1542
153
1101
1.48
4.35
1.3
1.3
40.39
35.73
iu/ml
0.11
48
369
153
1102
1.48
4.33
4.4
3.0
0.82
0.82
mmol/l
0.20
141
1039
222
1715
1.41
4.30
3.9
2.6
5003.56
8326.72
umol/l
0.56
195
1468
186
1400
1.43
4.16
3.7
3.9
228.61
316.03
ng/l
0.33
155
1130
65
391
1.72
3.93
1.2
1.2
84.81
148.47
iu/ml
1.31
25
156
412
3549
1.33
3.86
2.8
2.6
—
—
—
0
0
138
996
1.46
3.85
1.5
1.3
—
—
—
0
0
180
1367
1.41
3.81
1.3
1.2
0.66
1.76
u/ml
1.90
54
349
7
8
8.81
3.78
3.4
1.4
—
—
—
0
0
260
2103
1.35
3.72
4.6
3.1
16.35
89.82
e6/l
1.67
210
1630
20
79
2.57
3.65
1.1
1.1
1.51
1.54
g/l
0.15
20
71
260
2115
1.34
3.55
3.6
3.1
30.93
32.13
u/l
0.26
246
2007
90
608
1.54
3.45
2.4
1.9
400.66
381.08
nmol/l
0.31
85
552
14
47
3.01
3.42
1.0
1.1
—
—
—
0
0
155
1171
1.40
3.36
1.7
1.5
2.42
2.52
g/l
0.24
103
672
86
591
1.51
3.06
3.0
3.0
65.90
66.76
g/l
0.53
79
531
176
1383
1.35
2.98
2.8
3.0
2.45
2.46
mmol/l
0.57
154
1233
114
837
1.42
2.90
1.8
1.7
—
—
—
0
0
347
3000
1.27
2.88
2.2
2.0
101.92
94.62
pmol/l
1.85
166
1498
91
644
1.47
2.82
4.0
3.0
174.09
210.63
ng/l
0.62
81
597
114
843
1.41
2.79
1.8
1.7
—
—
—
0
0
59
384
1.58
2.70
2.6
3.0
4.32
4.49
pmol/l
0.72
49
338
214
1757
1.30
2.64
2.3
2.1
2.77
3.09
mg/l
1.34
184
1476
84
597
1.45
2.56
2.0
2.5
9.04
6.90
ug/l
0.38
71
522
25
129
1.97
2.52
1.1
1.3
300.36
239.16
miu/ml
0.29
11
63
35
202
1.77
2.52
1.2
1.1
—
—
—
0
0
454
4093
1.25
2.51
3.1
3.0
45.53
48.40
u/l
0.34
418
3762
87
627
1.43
2.47
3.1
3.5
1.24
1.23
mmol/l
0.36
74
546
148
1167
1.33
2.43
3.8
2.6
0.68
1.18
e6/l
3.15
98
650
128
989
1.35
2.41
3.0
2.2
2.39
2.34
g/l
0.44
114
914
20
97
2.09
2.39
1.3
1.3
—
—
—
0
0
265
2260
1.26
2.37
4.1
3.6
13.51
7.80
mg/mmol
0.60
154
1362
259
2204
1.26
2.36
3.5
3.0
6.80
6.90
mmol/l
0.14
218
1828
251
2131
1.26
2.33
3.6
3.1
1036.93
347.17
mg/l
0.66
138
1298
212
1768
1.27
2.28
1.5
1.5
25.92
21.30
nmol/l
1.43
185
1472
114
875
1.35
2.25
10.2
6.9
—
—
—
0
0
136
1072
1.32
2.24
3.1
2.2
12.72
12.46
umol/l
0.17
124
996
130
1631
0.76
2.21
2.2
2.2
—
—
—
0
0
34
203
1.70
2.21
1.2
1.1
—
—
—
0
0
17
81
2.12
2.14
2.1
2.0
6277.55
4189.56
u/l
—
8
29
12
49
2.47
2.11
1.2
1.3
—
—
—
0
0
9
32
2.83
2.00
1.6
1.3
—
—
—
0
0
19
98
1.96
1.96
1.7
1.4
—
—
—
0
0
18
91
2.00
1.96
1.1
1.1
—
—
—
0
0
46
307
1.53
1.95
2.1
1.9
1.46
1.53
g/l
0.19
38
272
118
931
1.31
1.94
3.2
2.2
21.89
21.86
%
0.01
88
791
309
2735
1.21
1.87
3.7
3.8
30.02
50.05
ng/l
0.88
214
1997
143
1164
1.28
1.87
1.8
1.7
—
—
—
0
0
8
28
2.88
1.86
1.1
1.5
—
—
—
0
0
112
883
1.31
1.86
1.6
1.4
—
—
—
0
0
131
1055
1.29
1.86
1.3
1.3
18.25
12.00
u/ml
0.35
58
379
175
1462
1.25
1.84
1.8
1.6
1.09
1.31
mg/l
0.33
133
1125
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
17
3.55
1.84
1.3
2.9
115.50
123.06
%
—
6
17
105
826
1.31
1.78
6.0
6.9
12.13
11.98
kpa
0.11
96
791
105
826
1.31
1.78
6.0
6.9
4.96
5.10
kpa
0.77
96
790
36
233
1.57
1.76
2.9
3.1
—
—
—
0
0
204
1742
1.23
1.75
6.0
5.3
2.32
3.17
ug/l
0.77
179
1549
17
89
1.93
1.71
1.2
1.2
332.40
268.20
u/ml
—
10
51
104
824
1.30
1.68
6.0
7.0
1.94
1.33
mmol/l
1.22
74
661
26
158
1.67
1.64
2.2
1.4
—
—
—
0
0
28
176
1.61
1.56
1.6
1.6
—
—
—
0
0
133
1102
1.25
1.51
4.2
2.8
2.04
2.68
e6/l
0.81
83
590
40
276
1.47
1.50
1.3
2.0
35.36
39.59
u/l
0.56
32
245
17
95
1.81
1.44
1.1
1.2
17.48
11.24
u/l
0.86
17
74
94
752
1.28
1.43
3.6
3.3
—
—
—
0
0
27
173
1.58
1.41
1.6
1.4
—
—
—
0
0
7
29
2.43
1.39
1.0
1.9
1.10
8.02
nmol/l
—
7
23
0
38
0.00
1.34
0.0
1.2
—
—
—
0
0
23
144
1.61
1.33
1.4
1.3
—
—
—
0
0
8
34
2.37
1.29
3.5
1.8
—
—
—
0
0
5
18
2.79
1.28
1.0
1.0
—
—
—
0
0
5
18
2.79
1.28
1.0
1.0
1777.40
1542.50
miu/ml
—
5
18
78
621
1.28
1.25
3.0
2.3
37.63
37.31
u/l
0.02
63
522
43
313
1.39
1.25
1.3
1.3
—
—
—
0
0
30
206
1.47
1.19
1.4
1.5
255.95
276.07
ug/g
0.24
19
131
15
87
1.74
1.15
2.5
1.8
32.80
32.41
pg
0.15
15
87
10
51
1.97
1.11
1.5
1.4
0.90
1.02
g/l
—
10
51
249
2248
1.16
1.11
2.8
3.0
1185.69
1365.64
ng/l
0.44
204
1931
162
1417
1.18
1.08
1.7
1.7
1221.20
1191.21
nmol/l
0.15
125
1056
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
28
196
1.44
1.03
1.1
1.3
—
—
—
0
0
30
213
1.42
1.03
3.0
3.7
3.83
3.93
mmol/l
0.48
30
208
9
48
1.88
1.00
1.0
1.1
—
84.29
—
0
7
46
353
1.32
1.00
4.8
2.8
25.31
25.38
mmol/l
0.05
46
341
9
50
1.81
0.97
1.2
1.1
—
—
—
0
0
0
31
0.00
0.96
0.0
1.1
—
—
—
0
0
0
31
0.00
0.96
0.0
1.1
—
—
—
0
0
31
225
1.39
0.96
4.1
4.2
37.87
82.12
mg/l
0.90
23
183
15
93
1.62
0.94
1.5
1.2
0.69
0.64
nmol/l
0.25
15
88
159
1406
1.16
0.94
6.2
4.5
23.38
21.55
%
0.99
91
712
31
226
1.39
0.94
4.0
4.2
35.21
50.56
mg/l
0.45
23
185
13
78
1.68
0.92
2.7
1.5
—
—
—
0
0
14
86
1.64
0.91
1.1
1.1
—
16.97
—
0
6
26
185
1.42
0.90
1.8
1.5
—
—
—
0
0
21
144
1.47
0.88
1.1
1.1
—
—
—
0
0
177
1586
1.15
0.88
1.8
1.7
50704667.11
14722449.55
pmol/l
0.31
142
1277
6
30
2.01
0.87
2.3
2.4
888.67
1191.07
u/ml
—
6
30
653
6343
1.15
0.86
15.5
13.9
73.92
76.63
ml/min/173m2
2.68
537
5203
8
45
1.79
0.84
1.4
1.3
—
—
—
0
0
338
3162
1.12
0.84
2.4
2.5
—
—
—
0
0
42
328
1.30
0.83
4.7
3.5
50.08
48.21
%
0.21
42
323
44
346
1.29
0.83
2.3
1.9
—
—
—
0
0
11
65
1.70
0.82
2.6
2.4
—
—
—
0
0
30
397
0.75
0.82
3.0
3.3
1.80
1.97
mmol/l
0.11
22
300
61
501
1.24
0.81
1.6
1.5
—
—
—
0
0
17
115
1.49
0.77
2.2
1.5
—
—
—
0
0
32
244
1.32
0.76
1.7
2.7
0.30
1.22
g/l
1.85
26
213
7
39
1.80
0.72
2.1
2.0
13.57
13.32
%
—
7
39
7
40
1.76
0.71
1.0
1.4
1.46
1.58
g/l
—
7
40
37
292
1.28
0.70
1.1
1.0
—
—
—
0
0
12
77
1.57
0.69
2.8
1.4
—
—
—
0
0
12
77
1.57
0.69
2.8
1.4
—
—
—
0
0
5
91
0.55
0.67
1.0
2.2
—
24.05
—
0
24
5
28
1.79
0.66
4.0
1.2
—
—
—
0
0
5
29
1.73
0.64
1.0
1.3
—
—
—
0
0
48
398
1.22
0.62
1.5
1.5
—
—
—
0
0
8
51
1.57
0.60
1.4
1.1
—
—
—
0
0
8
51
1.57
0.60
1.4
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
251.03
—
0
14
8
52
1.54
0.59
1.4
1.1
—
—
—
0
0
8
52
1.54
0.59
1.4
1.1
—
—
—
0
0
8
52
1.54
0.59
1.4
1.1
—
—
—
0
0
14
97
1.45
0.59
2.3
1.5
—
—
—
0
0
23
175
1.32
0.58
1.5
1.8
5732.47
15285.30
e6/l
0.80
15
126
8
53
1.51
0.58
2.3
2.1
—
—
—
0
0
75
654
1.16
0.57
4.2
3.1
2.00
2.20
mmol/l
0.19
67
540
13
90
1.45
0.55
1.8
1.5
47.57
66.99
%
—
7
62
9
60
1.51
0.54
1.0
1.1
—
—
—
0
0
20
151
1.33
0.54
2.0
2.2
16.97
16.08
%
—
6
67
9
62
1.46
0.53
1.3
1.2
43.00
51.34
u/l
—
9
55
14
100
1.41
0.52
1.4
1.8
88.86
89.72
%
0.28
14
100
14
100
1.41
0.52
1.2
1.3
—
—
—
0
0
17
126
1.36
0.52
1.2
1.5
293.65
283.85
mu/l
0.08
17
113
38
316
1.21
0.50
2.3
1.8
—
—
—
0
0
6
41
1.47
0.50
1.3
1.2
15.83
18.91
u/l
—
6
34
75
663
1.14
0.49
4.2
3.1
5.82
5.82
kpa
0.01
75
641
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
217
1.25
0.48
4.8
2.8
0.34
0.39
u/ml
0.27
16
120
20
254
0.78
0.46
1.5
1.7
—
—
—
0
0
18
138
1.31
0.45
2.1
1.7
—
—
—
0
0
20
156
1.29
0.45
2.2
1.5
—
—
—
0
0
21
165
1.28
0.45
3.3
3.2
0.75
0.86
nmol/l
0.70
16
132
18
139
1.30
0.44
1.0
1.1
3.38
3.82
mmol/l
2.39
13
130
23
184
1.26
0.43
1.6
1.5
—
—
—
0
0
5
31
1.62
0.43
3.8
1.6
—
—
—
0
0
5
31
1.62
0.43
1.6
1.2
—
—
—
0
0
5
31
1.62
0.43
3.8
1.6
—
—
—
0
0
23
186
1.24
0.40
1.5
1.7
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
8
60
1.34
0.40
3.8
1.5
—
—
—
0
0
62
551
1.14
0.40
3.6
2.7
4.70
4.43
kpa
0.28
62
532
14
106
1.33
0.39
2.6
1.4
—
—
—
0
0
14
106
1.33
0.39
2.6
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
15
115
1.31
0.39
2.5
1.5
—
—
—
0
0
21
169
1.25
0.39
2.0
1.7
2.82
5.14
iu/l
—
5
49
20
160
1.26
0.39
2.2
1.5
—
—
—
0
0
11
147
0.74
0.37
1.4
1.3
—
—
—
0
0
19
235
0.80
0.37
1.3
1.6
—
—
—
0
0
5
78
0.64
0.35
1.0
1.1
—
—
—
0
0
34
292
1.17
0.35
2.9
2.3
—
—
—
0
0
6
44
1.37
0.34
1.3
1.2
52.17
85.38
u/l
—
6
37
12
91
1.32
0.34
2.7
1.5
—
—
—
0
0
6
45
1.34
0.34
1.0
1.2
—
—
—
0
0
94
1017
0.91
0.33
3.5
3.1
0.84
0.78
ug/l
0.26
63
692
12
92
1.31
0.32
1.8
1.8
38.08
42.35
nmol/l
0.34
12
86
13
101
1.29
0.32
1.1
1.0
—
—
—
0
0
7
52
1.35
0.31
1.1
1.5
—
—
—
0
0
7
52
1.35
0.31
1.1
1.5
—
—
—
0
0
7
52
1.35
0.31
1.1
1.5
—
—
—
0
0
7
52
1.35
0.31
1.0
1.1
—
—
—
0
0
179
1702
1.07
0.30
4.3
3.6
86.71
89.35
%
0.68
173
1658
8
62
1.29
0.28
2.4
1.5
—
—
—
0
0
8
62
1.29
0.28
1.3
1.3
—
—
—
0
0
8
63
1.27
0.28
1.0
1.1
—
—
—
0
0
23
196
1.18
0.27
1.3
1.4
—
—
—
0
0
8
66
1.21
0.26
1.3
1.4
—
—
—
0
0
8
66
1.21
0.26
1.6
2.3
—
—
—
0
0
23
197
1.17
0.26
1.3
1.2
—
—
—
0
0
5
39
1.28
0.23
2.8
1.5
—
—
—
0
0
5
40
1.25
0.22
6.6
4.5
—
—
—
0
0
17
144
1.18
0.22
1.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
2.4
1.4
—
52.86
—
0
7
76
809
0.93
0.20
3.4
4.0
4.35
25.33
ug/l
1.42
66
673
23
202
1.14
0.20
1.6
1.6
1.65
2.51
mg/l
0.89
12
160
53
572
0.92
0.20
1.9
1.7
1.44
1.53
%
0.58
46
483
21
184
1.15
0.19
1.6
2.0
9.78
12.02
mg/l
0.68
21
170
10
81
1.24
0.19
1.0
1.1
—
—
—
0
0
7
58
1.21
0.18
1.0
1.1
—
—
—
0
0
16
138
1.16
0.17
1.4
1.3
—
—
—
0
0
16
138
1.16
0.17
1.4
1.3
—
—
—
0
0
5
67
0.74
0.17
2.0
1.6
—
—
—
0
0
5
68
0.73
0.17
1.0
1.3
7.86
7.27
mmol/l
—
5
54
46
428
1.08
0.16
7.6
8.7
94.47
94.12
%
0.30
46
423
20
178
1.13
0.15
1.6
1.5
0.08
0.08
iu/ml
—
6
43
18
159
1.14
0.15
3.4
2.4
79.54
58.60
ug/min
0.18
13
91
9
81
1.11
0.15
2.4
3.3
2.06
6.46
nmol/l
—
9
81
17
150
1.14
0.14
1.6
1.3
—
—
—
0
0
45
425
1.06
0.11
1.9
1.7
—
—
—
0
0
19
172
1.11
0.11
1.7
1.7
—
—
—
0
0
46
435
1.06
0.11
7.6
8.5
0.70
0.69
%
0.12
46
429
21
193
1.09
0.10
1.3
1.2
—
—
—
0
0
6
55
1.09
0.09
1.5
1.7
—
—
—
0
0
6
57
1.05
0.08
1.3
1.6
—
—
—
0
0
8
78
1.03
0.07
1.1
1.1
—
—
—
0
0
10
89
1.13
0.07
1.5
1.5
—
—
—
0
0
8
90
0.89
0.06
1.5
1.5
—
—
—
0
0
10
94
1.06
0.01
1.2
1.2
—
—
—
0
0
10
103
0.97
0.00
1.4
1.4
—
—
—
0
0
33
327
1.01
0.00
3.3
3.2
23.94
24.47
mmol/l
0.38
33
318
42
419
1.00
0.00
1.7
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
21.91
—
0
9
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
79
0.89
-0.00
3.3
3.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
16
160
1.00
-0.00
2.6
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
52.71
—
0
7
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
-0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERMELANIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERMELANIN | 0.735 [0.65, 0.83] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 3068 females with L12_OTHERMELANIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERMELANIN | 0.759 [0.63, 0.92] | 0.005 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1356 males with L12_OTHERMELANIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERMELANIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.146% |
| 5 | 0.531% | 0.976% |
| 10 | 1.325% | 2.501% |
| 15 | 2.461% | 4.56% |
| 20 | 4.247% | 7.678% |
Relationships between endpoints
↥Index endpoint: L12_OTHERMELANIN – Other melanin hyperpigmentation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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