obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
760 |
4. Check minimum number of eventsNone |
760 |
5. Include endpointsNone |
760 |
6. Filter based on genotype QC (FinnGen only) |
760 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L81
- Name in latin
- Alia hyperpigmentatio melaninalis
Similar endpoints
↥List of similar endpoints to
Other melanin hyperpigmentation
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5087 | 3489 | 1584 |
| Only index persons | 4808 | 3344 | 1464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.04 |
| Only index persons | 0.10 | 0.12 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 65.20 | 65.37 | 65.10 |
| Only index persons | 65.53 | 65.39 | 65.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 760 | 503 | 257 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.11 |
| Median age at first event (years) | 64.62 | 62.77 | 68.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 669
- Matched controls
- 6689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
4503599627370496.0
323.0
668
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
17.2
169.0
294
292
L57.0
ICD-10 Finland
Actinic keratosis
11.3
127.1
271
380
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
8.6
55.3
128
179
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
15.9
52.9
88
63
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
6.0
48.1
146
297
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
13.9
43.9
77
62
L82
ICD-10 Finland
Seborrhoeic keratosis
4.3
43.6
186
544
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
31.7
37.9
50
17
XQ848
NOMESCO Finland
Dermatological photography
11.9
34.7
65
60
R23.8
ICD-10 Finland
Other and unspecified skin changes
3.6
33.6
180
625
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
10.6
31.3
62
64
ZXC50
NOMESCO Finland
Cryotherapy
8.7
29.9
66
83
XQ845
NOMESCO Finland
Dermatoscopy
16.7
27.6
44
28
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
40.6
25.1
31
8
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
4.5
24.9
93
230
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
7.5
23.7
57
82
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
15.3
23.7
39
27
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
6.2
22.7
63
111
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
10.2
22.1
44
46
TQW99
NOMESCO Finland
Other minor procedure on skin
4.8
20.1
69
156
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
7.3
19.0
46
67
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.9
18.5
79
221
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
4.9
17.6
59
130
SPAT1153
SPAT
Removal of sutures
2.1
17.1
263
1574
ZXC20
NOMESCO Finland
Use of chemical agents
7.6
15.9
37
51
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
7.3
15.6
37
53
S18
ICPC
Laceration/cut
1.9
14.9
306
2024
D06BB10
ATC
imiquimod; topical
4.4
14.7
54
131
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
18.0
13.9
21
12
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
15.4
13.2
21
14
ZXC15
NOMESCO Finland
Use of photodynamic technique
7.6
13.1
30
41
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
14.4
12.8
21
15
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
14.4
12.8
21
15
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
20.5
12.5
18
9
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
9.2
12.3
25
28
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
5.9
11.8
32
56
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
4.4
11.8
42
100
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
20.4
11.2
16
8
L04AA01
ATC
[U] ciclosporin; systemic
8.8
11.1
23
27
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
14.2
11.0
18
13
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
6.7
10.9
27
42
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
28.5
10.8
14
5
L04AD01
ATC
ciclosporin; systemic
6.5
10.7
27
43
L81.1
ICD-10 Finland
Chloasma
33.1
10.4
13
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
10.1
123
649
ZZR00
NOMESCO Finland
Flap of skin
6.1
9.9
26
44
A02BC05
ATC
esomeprazole; systemic
1.7
9.6
293
2106
127
Kela drug reimbursment
Transplant complication
6.8
9.5
23
35
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
4.0
9.4
36
93
E0000UV
ATC
NA
1.7
9.4
252
1741
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.9
9.2
20
26
L04AA06
ATC
mycophenolic acid; systemic
6.5
8.8
22
35
A98
ICPC
Health maint/preventive medicine
2.7
8.8
636
5878
TQW80
NOMESCO Finland
Local dermatologic skincare
5.2
8.7
26
52
D03.5
ICD-10 Finland
Melanoma in situ of trunk
50.7
8.7
10
*
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
7.8
8.7
19
25
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
2.7
8.6
59
234
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
20.3
8.5
12
6
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
91.2
8.4
9
*
-
ICD-10 Finland
NA
4.4
8.4
29
68
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
10.9
8.3
15
14
Z94.0
ICD-10 Finland
Kidney transplant status
7.7
8.2
18
24
L85.3
ICD-10 Finland
Xerosis cutis
17.4
8.1
12
7
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
33.8
8.1
10
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
6.0
7.7
20
34
L91.0
ICD-10 Finland
Hypertrophic scar
25.3
7.6
10
*
D06BX02
ATC
ingenol mebutate; topical
5.5
7.6
21
39
S29
ICPC
Skin symptom/complaint other
1.9
7.5
120
695
40399
ICD-8 Finland
Hypertensive renal disease
+∞
7.3
7
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.2
7.3
72
344
R51.80
ICD-10 Finland
Headache
2.0
7.2
90
475
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
30.4
7.2
9
*
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
12.2
7.1
12
10
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
8.9
7.1
14
16
E000006
ATC
NA
2.4
7.1
59
262
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.0
146
924
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
6.9
381
3088
ZXA00
NOMESCO Finland
Right side
1.6
6.9
193
1325
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
6.9
229
1645
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
5.4
6.8
19
36
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
40.5
6.8
8
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
6.7
189
1299
L14
ICPC
Leg/thigh symptom/complaint
2.3
6.7
57
255
KMAK
NOMESCO Finland
NA
1.5
6.7
305
2362
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
6.6
420
3503
L04AX01
ATC
azathioprine; systemic
3.2
6.5
32
104
L01BB01
ATC
NA
70.5
6.4
7
*
4056
NOMESCO Finland
NA
70.5
6.4
7
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.1
6.4
32
105
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.8
6.4
39
146
E000001
ATC
NA
1.7
6.4
127
791
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.3
292
2260
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
9.4
6.3
12
13
C44.20
ICD-10 Finland
Malignant tumor of the skin of the outer ear and of the outer ear canal without histology
+∞
6.3
6
*
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
26.9
6.2
8
*
SPAT1301
SPAT
No procedures
1.6
6.1
214
1549
D10AX03
ATC
azelaic acid; topical
3.1
6.1
31
103
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
4.4
6.1
20
46
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
8.7
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
620
5118
2.15
14.99
20.1
18.4
13.8
13.8
%
0.00
609
5001
377
2712
1.77
13.33
2.3
2.2
79.6
79.6
nmol/l
0.01
338
2380
593
5019
1.83
10.58
8.1
7.3
75.9
78.6
u/l
1.14
558
4672
729
6675
3.26
10.46
12.0
10.6
23.8
24.5
u/l
0.72
702
6416
457
3623
1.66
10.14
9.5
8.8
3.8
4.1
e9/l
2.52
413
3170
403
3130
1.61
9.42
5.0
3.9
0.0
0.0
estimate
0.00
78
588
428
3390
1.60
9.09
7.8
6.2
1.2
1.2
mmol/l
0.06
371
2858
398
3106
1.59
8.94
6.5
5.5
1.2
1.2
mmol/l
0.42
365
2806
401
3154
1.57
8.57
6.4
5.4
0.0
0.0
estimate
0.00
82
581
738
6889
3.46
8.54
25.2
22.0
134.0
133.2
g/l
0.89
730
6761
404
3187
1.57
8.50
5.1
3.9
0.0
0.0
estimate
0.50
78
571
322
2418
1.58
8.36
5.2
4.2
—
—
—
0
0
717
6608
2.50
8.29
20.1
17.4
4.0
4.0
mmol/l
0.05
698
6415
26
75
3.55
7.88
1.7
1.4
—
—
—
0
0
623
5498
1.74
7.86
17.9
16.3
39.2
39.0
%
0.18
377
3616
557
4778
1.62
7.82
5.2
4.1
12.2
13.5
mm/h
1.12
519
4375
204
1393
1.63
7.78
5.5
4.2
1.0
1.0
kg/l
0.19
16
205
694
6339
2.09
7.76
5.9
5.2
2.6
2.7
mmol/l
1.08
634
5755
712
6594
2.26
7.23
19.9
17.3
139.9
139.7
mmol/l
1.20
693
6410
509
4313
1.55
7.18
5.8
4.7
4321.1
3094.5
e6/l
—
7
70
652
5872
1.78
7.10
5.8
4.9
2.0
1.9
mu/l
0.06
603
5297
678
6192
1.88
6.85
5.2
4.6
4.6
4.7
mmol/l
0.86
627
5658
654
5924
1.75
6.60
6.5
6.1
39.1
40.2
mmol/mol
3.37
611
5434
235
1722
1.53
6.43
5.8
4.1
0.0
0.0
estimate
0.50
78
558
131
837
1.68
6.36
6.6
4.5
1.0
1.0
mmol/l
0.36
122
756
360
2890
1.47
6.24
5.5
4.3
35.9
35.2
g/l
1.40
327
2673
561
4919
1.54
6.22
4.8
4.0
14.9
15.0
pmol/l
0.14
512
4413
676
6209
1.80
6.13
5.4
4.9
5.8
6.0
mmol/l
5.40
614
5583
298
2315
1.47
6.06
3.4
3.4
2.3
2.4
mmol/l
1.01
265
2015
712
6666
2.08
5.84
20.3
17.6
81.8
77.1
umol/l
2.14
712
6666
27
97
2.85
5.78
8.8
5.0
98.2
660.6
iu/ml
—
5
13
92
548
1.77
5.73
4.0
3.3
98.6
82.5
ng/l
0.85
84
472
668
6140
1.73
5.70
5.0
4.6
1.5
1.5
mmol/l
1.19
607
5556
42
847
0.47
5.65
4.6
4.7
34.0
33.3
%
0.13
29
552
324
2586
1.44
5.60
3.1
2.7
110.2
128.5
ug/l
1.10
295
2338
675
6230
1.75
5.57
16.5
14.6
22.5
24.3
mg/l
0.78
537
4957
192
1394
1.50
5.36
3.6
2.4
4.3
6.3
e6/l
1.43
169
1237
648
5935
1.62
5.29
4.5
4.1
1.2
1.3
mmol/l
1.82
584
5327
85
509
1.75
5.20
2.7
2.7
65.4
62.0
ml/min/173m2
0.34
41
211
239
1831
1.45
5.04
4.0
3.0
0.3
0.5
e6/l
1.68
186
1380
261
2049
1.42
4.76
2.9
2.4
58.9
57.4
u/l
0.30
233
1871
33
146
2.32
4.70
3.8
3.0
1.8
1.7
mg/l
0.15
28
132
108
715
1.60
4.52
2.4
2.5
6.3
7.9
umol/l
0.94
95
619
178
1313
1.46
4.52
3.7
4.0
238.2
314.8
ng/l
0.27
148
1070
254
2002
1.40
4.48
2.4
2.1
172.4
203.7
u/l
0.36
233
1879
20
72
2.83
4.31
1.1
1.1
1.5
1.5
g/l
0.11
20
64
139
985
1.50
4.29
1.9
1.8
30.6
29.5
s
0.99
133
952
145
1045
1.48
4.12
4.5
3.0
0.8
0.8
mmol/l
0.37
133
980
439
3821
1.35
4.01
5.2
4.5
6.5
6.7
mmol/l
1.44
423
3572
223
1748
1.39
3.99
1.7
1.6
1.2
1.3
mmol/l
1.16
175
1452
399
3435
1.34
3.86
6.4
6.0
12.0
11.3
umol/l
0.84
375
3252
7
8
8.82
3.78
3.4
1.4
—
—
—
0
0
142
1051
1.43
3.49
1.3
1.3
43.1
34.8
iu/ml
0.19
44
345
69
438
1.63
3.45
5.3
6.7
24.3
24.6
mmol/l
0.27
64
411
206
1638
1.35
3.29
4.0
2.6
5368.3
8541.6
umol/l
0.48
181
1392
85
578
1.53
3.19
2.5
1.9
384.7
384.7
nmol/l
0.00
80
524
126
933
1.42
3.08
1.5
1.3
—
—
—
0
0
169
1317
1.36
3.05
2.9
3.0
2.4
2.5
mmol/l
0.71
148
1173
110
796
1.45
3.05
1.9
1.7
—
—
—
0
0
379
3315
1.29
2.97
2.8
2.6
—
—
—
0
0
110
802
1.43
2.93
1.8
1.7
—
—
—
0
0
83
574
1.50
2.89
3.0
3.0
65.9
66.8
g/l
0.49
76
518
82
566
1.50
2.88
2.1
2.5
9.3
7.1
ug/l
0.39
69
492
241
2001
1.30
2.79
3.8
3.1
31.0
31.8
u/l
0.14
227
1902
13
48
2.74
2.73
1.0
1.1
—
—
—
0
0
56
361
1.60
2.68
2.7
3.0
4.3
4.5
pmol/l
0.57
47
315
86
613
1.45
2.59
4.0
3.0
175.0
216.5
ng/l
0.69
76
565
56
367
1.57
2.51
1.2
1.2
100.1
149.2
iu/ml
0.67
19
140
20
95
2.14
2.50
1.3
1.3
—
—
—
0
0
324
2826
1.26
2.45
2.2
2.1
100.5
94.4
pmol/l
1.32
155
1407
122
939
1.36
2.38
3.0
2.3
2.4
2.3
g/l
0.38
109
866
200
1652
1.29
2.36
2.3
2.1
2.8
3.1
mg/l
1.03
172
1392
162
1303
1.31
2.34
1.2
1.2
0.7
1.8
u/ml
1.75
45
328
140
1105
1.33
2.31
3.6
2.7
0.7
1.1
e6/l
2.54
94
611
19
92
2.09
2.28
1.7
1.4
—
—
—
0
0
120
1526
0.75
2.27
2.2
2.2
—
—
—
0
0
33
195
1.72
2.22
1.2
1.1
—
—
—
0
0
109
837
1.35
2.16
10.4
7.0
—
—
—
0
0
129
1018
1.32
2.13
3.1
2.3
12.5
12.6
umol/l
0.02
116
936
113
883
1.33
2.00
3.2
2.3
21.8
22.0
%
0.05
85
752
424
3864
1.22
1.98
3.1
3.1
46.6
47.9
u/l
0.12
388
3551
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
16
3.77
1.94
1.3
3.0
115.5
121.5
%
—
6
16
32
196
1.66
1.93
1.2
1.1
—
—
—
0
0
17
85
2.02
1.91
1.1
1.2
332.4
275.4
u/ml
—
10
49
137
1108
1.29
1.90
1.8
1.7
—
—
—
0
0
44
294
1.53
1.87
1.8
1.9
1.5
1.5
g/l
0.15
36
259
101
785
1.33
1.86
6.0
6.8
12.2
12.1
kpa
0.08
92
753
101
785
1.33
1.86
6.0
6.8
5.0
5.1
kpa
0.78
92
754
8
28
2.88
1.86
1.1
1.5
—
—
—
0
0
79
591
1.38
1.86
3.1
3.6
1.2
1.2
mmol/l
0.16
67
516
22
122
1.83
1.86
1.1
1.3
345.1
232.7
miu/ml
—
9
60
17
87
1.98
1.81
1.1
1.1
—
—
—
0
0
8
29
2.78
1.79
1.6
1.3
—
—
—
0
0
197
1677
1.24
1.77
1.5
1.5
25.8
21.5
nmol/l
1.22
174
1401
100
784
1.32
1.75
6.1
6.8
2.0
1.4
mmol/l
1.57
69
621
7
24
2.93
1.72
1.0
2.0
1.1
9.7
nmol/l
—
7
18
25
149
1.70
1.68
2.2
1.3
—
—
—
0
0
103
820
1.30
1.62
1.6
1.4
—
—
—
0
0
17
92
1.87
1.57
1.1
1.2
17.5
11.4
u/l
0.83
17
71
242
2129
1.20
1.55
4.2
3.9
13.6
7.8
mg/mmol
0.55
139
1287
27
169
1.62
1.54
1.6
1.6
—
—
—
0
0
235
2069
1.20
1.48
3.5
3.0
6.7
6.9
mmol/l
0.31
195
1709
191
1652
1.21
1.45
6.0
5.3
2.4
3.2
ug/l
0.70
169
1470
126
1045
1.25
1.43
4.0
2.8
2.1
2.6
e6/l
0.61
80
556
10
46
2.19
1.40
1.5
1.4
0.9
1.0
g/l
—
10
46
13
67
1.96
1.39
1.4
2.2
8312.2
4344.9
u/l
—
6
23
33
223
1.50
1.38
2.9
3.0
—
—
—
0
0
82
649
1.30
1.37
6.5
7.1
115.4
119.5
g/l
1.23
77
627
121
1005
1.24
1.36
1.3
1.3
20.2
11.9
u/ml
0.45
52
361
37
257
1.46
1.36
1.2
2.0
35.2
39.7
u/l
0.55
29
226
74
580
1.31
1.33
3.0
2.3
39.1
35.7
u/l
0.27
59
486
10
48
2.10
1.28
1.2
1.3
—
—
—
0
0
88
714
1.26
1.23
3.6
3.4
—
—
—
0
0
41
300
1.39
1.17
1.3
1.3
—
—
—
0
0
285
2595
1.16
1.16
3.8
3.8
30.8
51.8
ng/l
0.87
197
1893
0
36
0.00
1.14
0.0
1.2
—
—
—
0
0
159
1385
1.19
1.12
1.6
1.6
1.1
1.3
mg/l
0.24
119
1061
13
73
1.79
1.11
2.7
1.5
—
—
—
0
0
27
384
0.69
1.08
3.1
3.4
1.9
2.0
mmol/l
0.08
19
290
15
89
1.70
1.08
1.5
1.2
0.7
0.6
nmol/l
0.30
15
84
31
220
1.43
1.06
4.1
4.1
37.9
83.5
mg/l
0.90
23
177
31
220
1.43
1.06
4.0
4.2
35.2
51.2
mg/l
0.46
23
178
7
33
2.13
1.05
3.9
1.8
—
—
—
0
0
9
46
1.97
1.04
1.0
1.1
—
84.3
—
0
7
28
196
1.44
1.03
1.5
1.5
255.9
271.4
ug/g
0.18
19
122
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
7
35
2.01
1.00
2.1
2.1
13.6
13.3
%
—
7
35
11
61
1.82
0.99
2.7
2.6
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
30
0.00
0.97
0.0
2.4
—
—
—
0
0
8
143
0.55
0.94
3.0
2.0
128.1
129.4
g/l
—
8
102
6
28
2.15
0.91
2.3
2.1
888.7
1234.0
u/ml
—
6
28
17
110
1.56
0.91
2.2
1.5
—
—
—
0
0
40
307
1.32
0.89
2.1
1.9
—
—
—
0
0
152
1355
1.15
0.82
1.7
1.8
1244.2
1201.9
nmol/l
0.21
117
1008
612
5944
1.15
0.82
15.6
14.1
73.7
76.4
ml/min/173m2
2.48
504
4863
14
89
1.58
0.81
2.6
1.8
32.7
32.5
pg
0.09
14
89
14
89
1.58
0.81
2.3
1.5
—
—
—
0
0
149
1329
1.15
0.80
6.2
4.5
23.2
21.6
%
0.79
86
678
20
139
1.45
0.80
1.5
1.3
—
—
—
0
0
58
480
1.23
0.74
1.5
1.5
—
—
—
0
0
22
159
1.40
0.73
1.6
1.4
—
—
—
0
0
5
25
2.01
0.72
1.0
1.3
—
—
—
0
0
14
92
1.53
0.72
1.2
1.3
—
—
—
0
0
27
203
1.34
0.71
3.1
3.8
3.9
3.9
mmol/l
0.25
27
183
9
58
1.56
0.70
1.3
1.2
43.0
52.7
u/l
—
9
44
5
27
1.86
0.68
4.0
1.2
—
—
—
0
0
5
28
1.79
0.66
1.0
2.4
101.4
95.2
%
—
5
28
18
128
1.42
0.66
2.1
1.6
—
—
—
0
0
166
1514
1.12
0.65
1.9
1.7
53731783.4
15473699.4
pmol/l
0.32
134
1215
5
29
1.73
0.64
1.6
1.2
—
—
—
0
0
30
234
1.29
0.64
1.7
2.5
0.3
1.2
g/l
1.72
24
207
41
333
1.24
0.64
5.3
2.9
25.1
25.4
mmol/l
0.17
41
321
100
885
1.15
0.62
29.9
25.9
1.1
1.3
inr
—
10
110
8
49
1.64
0.62
1.4
1.1
—
—
—
0
0
8
49
1.64
0.62
1.4
1.1
—
—
—
0
0
16
113
1.42
0.61
1.2
1.5
302.8
286.2
mu/l
0.14
16
104
8
50
1.61
0.61
1.4
1.1
—
—
—
0
0
8
50
1.61
0.61
1.4
1.1
—
—
—
0
0
8
50
1.61
0.61
1.4
1.1
—
—
—
0
0
8
50
1.61
0.61
1.1
1.1
—
—
—
0
0
22
165
1.34
0.61
1.5
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
270.3
—
0
13
20
148
1.36
0.60
2.2
1.5
—
—
—
0
0
18
243
0.73
0.60
1.5
1.7
—
—
—
0
0
46
382
1.22
0.59
1.5
1.5
—
—
—
0
0
22
166
1.33
0.59
1.5
1.8
6060.1
16164.2
e6/l
0.80
14
120
32
255
1.27
0.59
3.0
2.2
2.8
3.2
g/l
1.54
23
199
313
2966
1.09
0.58
4.1
4.0
—
—
—
0
0
6
35
1.72
0.57
1.3
1.3
—
—
—
0
0
20
150
1.34
0.56
2.2
1.5
—
—
—
0
0
5
90
0.55
0.56
1.0
2.4
—
24.6
—
0
23
6
38
1.58
0.54
1.3
1.2
15.8
19.1
u/l
—
6
32
14
99
1.42
0.54
1.4
1.9
88.9
89.8
%
0.31
14
99
21
160
1.32
0.54
2.0
1.7
2.8
5.0
iu/l
—
5
48
229
2150
1.09
0.52
2.9
3.0
1249.2
1462.3
ng/l
0.45
187
1846
6
40
1.50
0.51
1.3
1.2
52.2
78.9
u/l
—
6
34
24
188
1.29
0.51
1.1
1.3
—
—
—
0
0
17
224
0.75
0.50
1.3
1.6
—
—
—
0
0
22
171
1.30
0.50
1.6
1.5
—
—
—
0
0
67
761
0.87
0.49
3.4
4.0
4.6
26.6
ug/l
1.40
58
636
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
208
1.26
0.48
4.8
2.7
0.3
0.4
u/ml
0.32
15
114
34
281
1.22
0.48
2.2
1.8
—
—
—
0
0
10
143
0.70
0.48
1.4
1.3
—
—
—
0
0
10
68
1.48
0.47
1.1
1.1
112.6
117.5
%
—
10
61
23
183
1.26
0.45
1.9
1.6
—
—
—
0
0
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
18
139
1.30
0.44
1.2
1.1
—
—
—
0
0
87
961
0.89
0.43
3.5
3.1
0.8
0.8
ug/l
0.27
60
654
19
149
1.28
0.42
2.1
2.3
17.3
16.2
%
—
5
66
33
278
1.20
0.40
1.1
1.0
—
—
—
0
0
5
34
1.47
0.40
3.8
1.5
—
—
—
0
0
5
34
1.47
0.40
3.8
1.5
—
—
—
0
0
8
60
1.34
0.40
1.3
1.3
—
—
—
0
0
8
60
1.34
0.40
1.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
20
160
1.26
0.39
3.3
3.2
0.8
0.8
nmol/l
0.51
15
127
5
76
0.66
0.36
1.0
1.1
—
—
—
0
0
6
42
1.43
0.35
1.0
1.3
—
—
—
0
0
16
126
1.28
0.35
1.6
1.7
—
—
—
0
0
22
181
1.22
0.35
1.3
1.2
—
—
—
0
0
68
616
1.11
0.34
4.5
3.3
2.3
2.3
mmol/l
0.01
58
498
30
257
1.17
0.32
2.8
2.2
11.6
10.5
g/l
0.50
23
219
32
276
1.17
0.32
3.0
2.2
3.6
3.7
g/l
0.33
23
195
16
128
1.26
0.32
1.4
1.3
—
—
—
0
0
16
128
1.26
0.32
1.4
1.3
—
—
—
0
0
32
277
1.16
0.31
3.0
2.2
—
—
—
0
0
32
277
1.16
0.31
3.0
2.2
6.8
7.5
g/l
1.15
23
205
10
75
1.34
0.30
1.0
1.1
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
—
—
0
0
7
56
1.25
0.29
2.4
1.4
—
—
—
0
0
68
625
1.10
0.27
4.5
3.3
5.8
5.8
kpa
0.18
68
604
10
77
1.30
0.26
2.2
1.6
—
—
—
0
0
14
114
1.23
0.25
2.5
1.4
—
—
—
0
0
31
348
0.89
0.23
9.7
8.6
24.8
24.6
mmol/l
0.13
26
324
5
38
1.32
0.23
3.8
1.5
—
—
—
0
0
5
39
1.28
0.23
6.6
4.5
—
—
—
0
0
11
88
1.25
0.22
1.8
1.5
45.0
68.4
%
—
6
59
22
191
1.16
0.22
1.6
1.6
1.7
2.5
mg/l
0.65
11
147
13
107
1.22
0.21
1.3
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
44
402
1.10
0.21
1.9
1.7
—
—
—
0
0
20
173
1.16
0.21
1.6
1.9
9.6
12.1
mg/l
0.72
20
159
5
43
1.16
0.21
1.0
1.6
—
—
—
0
0
5
43
1.16
0.21
1.0
1.6
—
—
—
0
0
5
43
1.16
0.21
1.0
1.6
—
—
—
0
0
11
89
1.24
0.21
2.7
1.5
—
—
—
0
0
50
542
0.92
0.21
2.0
1.7
1.4
1.5
%
0.96
43
458
0
13
0.00
0.21
0.0
1.4
—
7.1
—
0
7
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
53
1.13
0.18
1.3
1.6
—
—
—
0
0
56
522
1.08
0.18
3.9
2.7
4.4
4.4
kpa
0.05
56
504
17
147
1.16
0.18
1.6
1.3
—
—
—
0
0
7
59
1.19
0.18
4.1
1.5
—
—
—
0
0
7
63
1.11
0.17
1.7
2.3
—
—
—
0
0
7
63
1.11
0.17
1.0
1.1
—
—
—
0
0
5
66
0.76
0.17
1.0
1.2
7.9
7.5
mmol/l
—
5
41
7
90
0.78
0.14
1.4
1.5
—
—
—
0
0
21
189
1.11
0.14
1.3
1.1
—
—
—
0
0
11
94
1.17
0.13
1.8
1.7
39.3
42.6
nmol/l
0.23
11
88
18
161
1.12
0.13
1.8
1.8
—
—
—
0
0
5
44
1.14
0.10
2.4
1.3
—
52.9
—
0
7
5
47
1.06
0.09
1.2
1.8
—
—
—
0
0
7
64
1.09
0.08
1.3
1.5
—
—
—
0
0
17
156
1.09
0.08
3.2
2.5
80.1
64.5
ug/min
0.12
12
91
8
77
1.04
0.07
2.6
3.3
2.1
6.5
nmol/l
—
8
77
11
99
1.11
0.06
1.1
1.1
—
—
—
0
0
20
187
1.07
0.06
1.4
1.4
—
—
—
0
0
9
100
0.90
0.06
1.3
1.4
—
—
—
0
0
10
91
1.10
0.04
1.2
1.2
—
—
—
0
0
42
410
1.03
0.02
8.0
8.4
94.4
94.1
%
0.27
42
405
40
406
0.98
0.00
1.7
1.6
—
—
—
0
0
42
415
1.01
0.00
8.0
8.2
0.7
0.7
%
0.21
42
409
58
585
0.99
0.00
6.8
6.3
1.3
1.4
mmol/l
0.49
52
560
16
159
1.01
0.00
2.6
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
39.5
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
21.9
—
0
9
6
59
1.02
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
7
79
0.89
0.00
3.3
3.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERMELANIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERMELANIN | 0.735 [0.65, 0.83] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 3068 females with L12_OTHERMELANIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERMELANIN | 0.759 [0.63, 0.92] | 0.005 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1356 males with L12_OTHERMELANIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERMELANIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.146% |
| 5 | 0.531% | 0.976% |
| 10 | 1.325% | 2.501% |
| 15 | 2.461% | 4.56% |
| 20 | 4.247% | 7.678% |
Relationships between endpoints
↥Index endpoint: L12_OTHERMELANIN – Other melanin hyperpigmentation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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