mixed connective tissue disease: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus , scleroderma , and polymyositis . Some affected people may also have symptoms of rheumatoid arthritis . Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) , corticosteroids and immunosuppresivedrugsmay help manage the symptoms.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
675 |
4. Check minimum number of eventsNone |
675 |
5. Include endpointsNone |
675 |
6. Filter based on genotype QC (FinnGen only) |
659 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M35
- Name in latin
- Alia syndromata mixta
Similar endpoints
↥List of similar endpoints to
Other overlap syndromes
based on the number of shared cases.
Similar with more cases:
- Mixed connective tissue disease
- Other systemic involvement of connective tissue (FG)
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3427 | 2668 | 727 |
| Only index persons | 3153 | 2488 | 665 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.02 |
| Only index persons | 0.08 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.82 | 55.40 | 57.44 |
| Only index persons | 55.07 | 54.63 | 56.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 659 | 508 | 151 |
| Unadjusted period prevalence (%) | 0.15 | 0.18 | 0.07 |
| Median age at first event (years) | 52.97 | 51.19 | 58.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 675
- Matched controls
- 6750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
307.7
675
*
P01BA02
ATC
hydroxychloroquine; oral
55.6
307.7
472
271
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
239.6
307.7
177
10
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
40.7
307.7
474
370
L04AX03
ATC
methotrexate; systemic
17.6
304.2
322
332
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
17.2
253.3
248
220
L04AX01
ATC
azathioprine; systemic
24.4
222.2
170
92
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
1156.8
185.7
173
*
C08CA05
ATC
nifedipine; systemic
12.5
155.3
174
183
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
11.3
151.3
184
217
XX9XE
NOMESCO Finland
Other ultrasound examination
46.5
137.8
82
20
L01BA01
ATC
methotrexate; systemic
16.3
135.7
123
91
H02AB06
ATC
prednisolone; systemic
9.1
134.0
556
2283
L04AA06
ATC
mycophenolic acid; systemic
35.7
123.6
79
25
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.5
122.9
460
1677
M35.3
ICD-10 Finland
Polymyalgia rheumatica
23.9
119.3
88
42
L88
ICPC
Rheumatoid/seropositive arthritis
13.2
115.8
119
108
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
1128.8
101.9
97
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.0
96.6
150
233
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
488.2
88.3
86
*
H02AB07
ATC
prednisone; oral
5.6
88.1
213
510
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.5
75.1
120
190
M05BA04
ATC
alendronic acid; oral
5.9
70.9
149
310
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.6
68.5
154
340
I73.0
ICD-10 Finland
Raynaud syndrome
16.0
68.1
60
41
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
59.2
425
2131
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.7
57.7
87
128
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.4
50.7
78
117
PAW37
NOMESCO Finland
Biopsy of temporal artery
252.1
46.6
47
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
43.8
289
1315
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
10.5
42.3
48
49
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
41.1
39
*
R50.9
ICD-10 Finland
Fever, unspecified
3.6
39.1
161
547
R4120
NOMESCO Finland
Occupational therapy
4.9
38.7
94
217
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.2
37.0
46
53
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
34.7
33
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.0
34.6
55
85
L04AA01
ATC
[U] ciclosporin
13.4
33.4
32
25
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
343.1
33.2
33
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
8.3
32.7
44
56
L04AA13
ATC
[U] leflunomide
7.4
32.6
49
71
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.1
32.3
50
75
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.6
31.3
80
192
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
30.4
29
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
30.4
169
679
ZX120
NOMESCO Finland
Intravenous
3.7
29.9
108
333
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.4
29.7
81
204
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
29.2
198
882
M05BA07
ATC
risedronic acid; oral
5.8
28.6
54
99
M13.9
ICD-10 Finland
Arthritis, unspecified
4.0
28.3
89
249
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.6
28.2
106
335
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
293.1
28.0
28
*
XPX04
NOMESCO Finland
Angioscopy
151.3
27.9
29
*
C08CA02
ATC
felodipine; oral
3.7
27.8
98
297
L04AD01
ATC
ciclosporin; systemic
9.6
27.6
33
36
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
6.6
27.3
45
72
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
26.9
202
942
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
26.8
128
469
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
26.6
363
2220
A07EC01
ATC
sulfasalazine; oral, rectal
3.7
25.7
90
271
H02AB04
ATC
methylprednisolone; systemic
2.9
25.3
141
563
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
25.2
24
*
XG410
NOMESCO Finland
Flow-volume spirometry
5.4
24.7
50
98
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
24.6
122
456
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.4
24.4
50
99
A02BC02
ATC
pantoprazole; systemic
2.5
23.9
507
3680
SBA10
NOMESCO Finland
Measurement of salivary flow rate
21.0
23.2
34
17
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
23.1
97
328
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
23.0
22
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
22.1
100
353
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.2
21.1
92
317
A07AA02
ATC
nystatin; oral
3.7
21.0
71
208
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
20.8
58
148
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
7.2
20.5
31
45
TGC00
NOMESCO Finland
Bronchial lavation
6.0
20.4
37
65
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
205.8
19.7
20
*
E0000UV, ,
ATC
2.1
19.3
326
2084
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
5.8
19.3
36
65
R06.0
ICD-10 Finland
Dyspnoea
2.2
19.3
222
1226
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
23.4
19.2
27
12
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
19.2
76
247
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
19.0
192
1005
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.1
18.9
33
56
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
18.8
18
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
6.0
18.5
33
57
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
17.8
17
*
GD1AD
NOMESCO Finland
Thorax CT examination
3.7
17.7
58
166
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
17.6
184
971
WZA10
NOMESCO Finland
Extensive medical or dental certificate
8.0
17.5
24
31
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
17.5
167
850
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
17.4
70
229
H02AB09
ATC
hydrocortisone; systemic
6.0
17.3
31
54
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.7
17.0
40
89
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
16.9
77
272
M33.2
ICD-10 Finland
Polymyositis
174.1
16.6
17
*
A02BC03
ATC
lansoprazole; oral
2.1
16.5
229
1345
C03CA01
ATC
furosemide; systemic
2.1
16.3
211
1207
G04BE03
ATC
sildenafil; oral
21.6
16.1
23
11
A02BC01
ATC
omeprazole; systemic
2.1
16.0
217
1261
N02AX02
ATC
tramadol; systemic, rectal
2.0
15.9
311
2053
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.0
15.8
28
48
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.9
15.8
35
74
M01AH01
ATC
celecoxib; oral
2.3
15.7
150
760
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
5.8
15.7
29
52
I77.6
ICD-10 Finland
Arteritis, unspecified
87.2
15.6
17
*
M35
ICD-10 Finland
Other systemic involvement of connective tissue
163.6
15.5
16
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
5.9
15.5
28
49
M05BX04
ATC
denosumab; parenteral
3.3
15.5
61
197
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.7
15.4
91
370
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.7
15.1
90
367
Z3231
NOMESCO Finland
Registered nurse
2.0
15.1
207
1204
J01FF01
ATC
clindamycin; systemic
2.0
14.9
211
1240
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
14.8
86
346
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
6.3
14.8
25
41
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.9
14.7
72
264
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
21.6
14.7
21
10
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
5.8
14.7
27
48
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
14.6
14
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
14.6
14
*
C08CA01
ATC
amlodipine; oral
1.9
14.4
268
1725
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.8
14.3
74
280
J01DB01
ATC
cefalexin; oral
2.4
14.3
577
4815
D07AC01
ATC
betamethasone; topical
1.9
14.2
261
1671
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
14.2
106
481
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
14.0
263
1695
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.7
14.0
46
132
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.0
14.0
65
232
UJF32
NOMESCO Finland
Coloscopy
2.0
13.8
190
1102
J01MA12
ATC
levofloxacin; systemic
2.2
13.7
140
725
A02BC05
ATC
esomeprazole; systemic
1.9
13.7
301
2037
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
10.4
13.6
26
26
J01MA14
ATC
moxifloxacin; systemic
2.7
13.6
77
306
A01AB09
ATC
miconazole; local oral
2.7
13.5
80
325
M13.0
ICD-10 Finland
Polyarthritis, unspecified
11.8
13.4
24
21
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.4
13.2
48
147
K11.2
ICD-10 Finland
Sialoadenitis
4.0
13.0
37
96
M35.7
ICD-10 Finland
Hypermobility syndrome
23.1
12.9
18
8
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
5.9
12.8
23
40
A02BA02
ATC
ranitidine; systemic
2.1
12.8
151
826
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
12.5
12
*
L93.0
ICD-10 Finland
Discoid lupus erythematosus
20.5
12.5
18
9
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
132.4
12.5
13
*
TEA00
NOMESCO Finland
Biopsy of lip
14.7
12.3
20
14
N03AX16
ATC
[U] pregabalin
2.0
12.2
173
1008
L99
ICPC
Musculoskeletal disease other
5.4
12.1
24
46
L20
ICPC
Joint symptom/complaint NOS
3.7
12.0
39
111
M79.7
ICD-10 Finland
Fibromyalgia
3.9
12.0
36
97
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
11.9
108
532
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
11.7
219
1393
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
11.5
94
442
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
+∞
11.5
11
*
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
+∞
11.5
11
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
11.5
11
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
11.5
11
*
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
11.5
11
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
11.4
65
258
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.8
11.4
35
96
J01MA02
ATC
ciprofloxacin; systemic
1.8
11.2
259
1752
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.3
11.2
29
70
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
11.1
292
2049
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
11.0
65
263
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
11.0
81
364
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.2
11.0
29
71
S01XA18
ATC
ciclosporin; ophthalmic
12.2
10.9
19
16
A01AB04
ATC
amphotericin B; local oral
3.1
10.8
47
161
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
10.8
60
236
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.9
10.7
32
86
M31.6
ICD-10 Finland
Other giant cell arteritis
61.0
10.7
12
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.5
10.6
37
111
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
4.9
10.6
23
48
M01AH02
ATC
rofecoxib; oral
2.2
10.5
101
508
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
111.7
10.4
11
*
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
10.4
10
*
C02KX04
ATC
macitentan; oral
+∞
10.4
10
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.6
10.4
35
102
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
10.4
73
321
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
8.4
10.4
22
27
P01BA01
ATC
chloroquine; systemic
13.4
10.2
17
13
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.9
10.1
30
80
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
11.5
10.1
18
16
B02.9
ICD-10 Finland
Zoster without complication
2.6
10.1
58
232
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.5
10.1
65
275
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
9.9
83
395
NXL00
NOMESCO Finland
Biopsy of muscle
26.5
9.8
13
5
L01AA01
ATC
cyclophosphamide; systemic
26.5
9.8
13
5
N03AX12
ATC
[U] gabapentin; oral
2.0
9.8
122
675
J05AB01
ATC
aciclovir; systemic
1.8
9.7
169
1044
J02AC01
ATC
fluconazole; systemic
1.7
9.7
305
2224
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.4
9.7
24
56
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.4
9.7
24
56
M60.9
ICD-10 Finland
Myositis, unspecified
15.3
9.5
15
10
S18
ICPC
Laceration/cut
1.7
9.5
307
2250
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
101.4
9.4
10
*
M33.1
ICD-10 Finland
Other dermatomyositis
+∞
9.4
9
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
9.4
9
*
NF1AA
NOMESCO Finland
Hip X-ray examination
2.4
9.3
66
291
M05BA06
ATC
ibandronic acid; systemic
4.3
9.2
24
58
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
9.2
39
132
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.4
9.2
23
54
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
8.5
9.1
19
23
M01AC06
ATC
meloxicam; systemic, rectal
1.7
9.1
264
1876
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
9.2
9.1
18
20
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
9.1
131
761
K11.70
ICD-10 Finland
Hypoptyalism
12.8
8.9
15
12
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.6
8.9
21
47
N06AA09
ATC
amitriptyline; systemic
2.2
8.9
74
351
M25.5
ICD-10 Finland
Pain in joint
1.7
8.8
233
1612
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
8.8
8.8
18
21
D68.8
ICD-10 Finland
Other specified coagulation defects
7.3
8.8
20
28
H25.8
ICD-10 Finland
Other senile cataract
2.2
8.7
76
368
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.7
8.6
20
44
ZX140
NOMESCO Finland
Intra articular
11.8
8.6
15
13
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.1
8.6
36
121
R1250
NOMESCO Finland
Evaluation of functional capability
4.1
8.6
23
57
R4110
NOMESCO Finland
Physiotherapy
1.7
8.5
188
1237
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
8.5
195
1297
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
20.3
8.5
12
6
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
8.5
90
469
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
8.0
8.4
18
23
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.7
8.4
26
72
C02KX01
ATC
bosentan; oral
+∞
8.3
8
*
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
9.6
8.3
16
17
S97
ICPC
Chronic ulcer skin
2.7
8.3
46
181
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.3
251
1795
M01CB01
ATC
sodium aurothiomalate; parenteral
6.6
8.2
20
31
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
14.7
8.2
13
9
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
8.2
353
2746
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
8.1
116
670
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.1
8.1
83
427
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
8.1
70
337
N06AX21
ATC
duloxetine; oral
2.0
8.0
91
487
Z3226
NOMESCO Finland
Physiotherapist
1.8
8.0
129
775
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
7.9
79
402
E000002, ,
ATC
2.1
7.9
79
402
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.0
7.9
34
116
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.6
7.9
26
75
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
3.0
7.8
34
117
A46
ICD-10 Finland
Erysipelas
2.0
7.8
91
491
TNG10
NOMESCO Finland
Puncture of knee
6.0
7.7
20
34
ELA30
NOMESCO Finland
Biopsy of salivary gland
45.5
7.7
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
7.7
40
152
M02AA10
ATC
ketoprofen; topical
1.9
7.7
111
643
J01AA02
ATC
doxycycline; systemic
1.7
7.6
514
4417
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.3
7.6
28
87
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.1
7.6
32
108
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
25.3
7.6
10
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
7.5
74
376
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
6.6
7.5
18
28
Z2221
NOMESCO Finland
Medical doctor
1.6
7.4
192
1312
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
13.5
7.4
12
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.4
128
784
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.3
7.4
55
249
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
11.0
7.3
13
12
M35.2
ICD-10 Finland
Behçet disease
+∞
7.3
7
*
L28
ICPC
Limited function/disability (L)
1.8
7.3
117
700
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.9
7.1
32
112
E000001, ,
ATC
1.7
7.1
137
864
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
4.1
7.1
19
47
J05AB11
ATC
valaciclovir; oral
1.8
7.1
112
666
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
12.2
7.1
12
10
SPAT1255
SPAT
Intravenous administration of medicine
2.5
7.1
44
183
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
7.1
92
515
1XC02, ,
NOMESCO Finland
10.2
7.1
13
13
B01AA03
ATC
warfarin; systemic
1.8
7.0
108
637
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.4
7.0
25
76
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.4
7.0
47
203
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.6
7.0
41
166
D70.89
ICD-10 Finland
Neutropenic splenomegaly
6.4
7.0
17
27
H05AA02
ATC
teriparatide; parenteral
14.0
6.9
11
8
318
Kela drug reimbursment
Teriparatide
14.0
6.9
11
8
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
6.9
60
290
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
6.9
132
832
K75.4
ICD-10 Finland
Autoimmune hepatitis
40.5
6.8
8
*
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
16.9
6.8
10
6
NH3AE
NOMESCO Finland
Feet ultrasound examination
16.9
6.8
10
6
J01FA10
ATC
azithromycin; systemic
1.5
6.7
392
3207
J47
ICD-10 Finland
Bronchiectasis
4.1
6.7
18
45
R03AC02
ATC
salbutamol; inhalant
1.5
6.6
371
3002
M01AB55
ATC
diclofenac, combinations; oral
2.3
6.6
51
234
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.0
6.6
28
95
XW000
NOMESCO Finland
Bone marrow biopsy
2.9
6.6
30
106
B01AB05
ATC
enoxaparin; parenteral
1.6
6.6
207
1477
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
2.7
6.6
34
129
N02AC04
ATC
dextropropoxyphene; oral
3.1
6.6
27
90
TQW40
NOMESCO Finland
Remowal of suture of skin
2.3
6.6
49
222
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
10.2
6.6
12
12
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
6.5
81
446
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.9
6.5
30
107
L17
ICPC
Foot/toe symptom/complaint
1.6
6.5
193
1359
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
6.4
45
198
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
14.5
6.4
10
7
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
6.4
257
1934
WX892
NOMESCO Finland
Monitored bed care
2.3
6.4
50
231
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.0
6.4
28
97
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.5
6.4
38
155
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
5.3
6.4
18
35
S29
ICPC
Skin symptom/complaint other
1.7
6.3
125
792
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
11.2
6.3
11
10
J01FA01
ATC
erythromycin; systemic
1.8
6.3
94
550
TPX00
NOMESCO Finland
Biopsy of artery or vein
+∞
6.3
6
*
M05.2
ICD-10 Finland
Rheumatoid vasculitis
+∞
6.3
6
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
6.3
6
*
7109X
ICD-9 Finland
Diffuse diseases of connective tissue, Unspecified diffuse connective tissue disease
+∞
6.3
6
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
6.3
6
*
I27.0
ICD-10 Finland
Primary pulmonary hypertension
26.9
6.2
8
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
6.2
99
591
WX204
NOMESCO Finland
Axillary plexus blockaced
2.8
6.1
29
105
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
4.2
6.1
16
39
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
6.1
76
419
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.2
6.1
24
78
GD2SN
NOMESCO Finland
Lung ventilation SPECT
12.7
6.1
10
8
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
12.7
6.1
10
8
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
6.1
180
1263
M01CB03
ATC
auranofin; oral
8.7
6.1
12
14
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
2.9
6.1
28
100
D07AD01
ATC
clobetasol; topical
1.7
6.1
114
713
J01DA01
ATC
[U] cefalexin
1.5
6.1
410
3425
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
6.0
25
84
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
246
145
26.12
314.36
4.7
1.3
—
—
—
0
0
265
122
35.11
307.65
2.0
1.1
17.35
2.44
u/ml
—
89
9
267
135
32.07
307.65
2.0
1.1
38.11
1.20
u/ml
—
39
8
266
124
34.75
307.65
2.1
1.1
51.13
4.06
u/ml
13.31
150
14
231
92
37.65
307.65
2.0
1.1
3.17
16.48
u/ml
—
36
5
218
106
29.90
301.51
2.1
1.1
52.49
4.17
u/ml
—
55
9
220
168
18.94
244.13
2.1
1.1
1.98
2.62
u/ml
0.12
13
11
361
714
9.72
198.92
2.2
1.3
1454.19
360.54
titre
19.19
217
149
84
36
26.51
118.74
1.5
1.1
—
—
—
0
0
84
36
26.51
118.74
1.5
1.1
—
—
—
0
0
84
37
25.79
117.49
1.5
1.1
—
—
—
0
0
84
37
25.79
117.49
1.5
1.1
—
—
—
0
0
84
37
25.79
117.49
1.5
1.1
—
—
—
0
0
573
2809
7.88
101.66
16.0
5.4
0.15
0.18
e9/l
6.83
544
2483
544
2550
6.84
101.54
16.0
5.2
2.52
2.76
%
2.17
533
2376
545
2564
6.84
101.13
16.7
5.5
9.44
8.42
%
12.11
534
2396
570
2793
7.69
100.79
15.8
5.1
1.56
1.95
e9/l
10.66
541
2499
546
2608
6.72
98.40
15.7
5.1
58.77
57.02
%
2.91
535
2446
547
2642
6.64
96.50
16.4
5.3
26.38
28.29
%
4.23
536
2476
395
1545
4.75
88.64
4.2
2.0
132.14
221.21
u/l
1.26
376
1461
54
15
39.04
87.13
1.2
1.0
—
—
—
0
0
583
3169
7.16
83.89
18.0
8.4
3.77
4.01
e9/l
2.23
553
2767
159
307
6.47
82.53
2.1
1.7
1.34
1.36
g/l
0.05
153
283
339
1423
3.78
63.50
3.7
3.0
813.65
1230.51
ng/l
1.92
310
1199
53
34
16.83
62.09
1.5
1.1
80.20
—
u/ml
—
10
0
53
35
16.35
61.15
1.5
1.1
60.60
—
u/ml
—
15
0
92
150
6.94
55.51
2.7
2.1
130.35
281.67
ug/l
1.79
84
142
57
51
12.12
55.10
2.6
2.2
—
—
—
0
0
441
2363
3.50
53.15
3.2
2.2
80.82
77.03
nmol/l
2.33
414
2117
66
79
9.15
51.87
1.6
1.2
4.46
8.10
u/ml
0.50
41
30
483
2774
3.61
51.22
6.9
3.5
0.00
0.01
estimate
0.80
128
501
478
2738
3.56
50.68
6.8
3.5
0.00
0.00
estimate
0.50
132
547
613
4174
6.10
49.85
13.5
3.7
14.84
11.80
mm/h
5.72
594
3844
477
2747
3.51
49.73
9.4
4.8
0.00
0.00
estimate
0.50
126
514
59
76
8.41
43.61
1.8
1.2
5.97
5.37
u/ml
0.05
39
19
85
167
5.68
42.18
1.6
1.5
0.01
0.13
iu/ml
0.80
15
26
603
4262
4.89
41.45
15.2
6.8
71.76
77.69
u/l
3.97
593
3995
447
2642
3.05
41.22
8.1
6.4
1.22
1.22
mmol/l
1.07
391
2245
236
991
3.12
40.65
1.4
1.3
55.47
33.29
iu/ml
1.21
95
322
252
1126
2.98
38.52
1.9
1.5
2.43
2.38
g/l
0.14
196
674
130
390
3.89
37.95
2.0
3.2
67.69
67.02
g/l
0.37
123
354
156
545
3.42
36.06
3.4
3.9
235.71
257.43
u/l
0.68
147
517
348
1892
2.73
35.97
5.5
3.4
104.58
76.95
e6/l
0.34
250
1313
213
936
2.86
32.76
1.4
1.3
14.34
10.60
u/ml
0.29
84
359
139
499
3.25
30.36
2.0
1.9
348.46
386.21
nmol/l
0.92
132
462
392
2407
2.50
29.46
6.3
5.7
1.22
1.22
mmol/l
0.43
364
2189
35
8
45.98
28.95
1.2
1.0
—
—
—
0
0
30
27
11.58
28.62
1.4
1.2
—
—
—
0
0
171
726
2.82
27.51
2.8
2.3
2.34
2.37
g/l
0.26
160
673
160
675
2.80
25.90
2.8
2.4
19.32
22.40
%
2.09
144
583
177
797
2.65
25.14
3.0
2.3
11.07
13.13
umol/l
3.88
168
735
218
1089
2.48
24.88
3.1
2.4
4.11
7.25
e6/l
2.62
198
979
282
1583
2.34
24.70
4.6
2.9
26.66
105.59
e6/l
1.14
241
1206
264
1447
2.35
24.37
4.2
2.8
0.20
0.46
e6/l
3.22
225
1081
69
179
4.18
24.26
1.8
2.4
7.06
7.42
g/l
1.11
64
164
69
179
4.18
24.26
1.8
2.4
3.47
3.60
g/l
0.36
64
164
50
100
5.32
24.11
5.1
3.0
3.84
4.28
e9/l
0.69
50
100
68
179
4.11
23.44
1.8
2.4
—
—
—
0
0
65
166
4.23
23.32
1.8
2.5
13.28
10.76
g/l
1.91
60
150
50
103
5.16
23.32
5.5
3.3
59.26
58.95
%
0.05
50
103
77
224
3.75
23.07
1.7
2.2
40.57
40.65
u/l
0.01
69
201
417
2862
2.20
21.21
6.0
5.7
9.33
10.50
umol/l
2.54
397
2714
102
374
3.03
21.08
2.7
2.9
77.42
185.00
ng/l
6.05
94
340
322
2005
2.16
20.97
4.5
3.4
23.05
53.22
ng/l
0.95
235
1313
62
167
3.99
20.67
1.8
2.5
3.04
2.96
g/l
0.21
57
152
335
2128
2.14
20.60
7.4
3.7
—
—
—
0
0
131
560
2.66
20.28
2.9
2.6
1.71
1.81
%
0.51
118
503
255
1488
2.15
19.24
7.2
3.7
0.00
0.00
estimate
0.80
125
509
55
144
4.07
19.05
2.5
2.6
—
—
—
0
0
55
146
4.01
18.69
1.9
2.5
36.26
38.34
g/l
1.57
50
131
236
1362
2.13
18.11
2.9
2.1
3.31
3.05
mg/l
0.85
207
1158
69
219
3.40
18.05
2.4
2.0
1.65
1.48
g/l
0.57
63
191
161
815
2.28
17.00
2.1
1.8
—
—
—
0
0
230
1347
2.07
16.73
2.7
2.6
1700.26
7064.32
umol/l
2.81
213
1175
24
14
17.73
15.71
2.1
1.3
7.86
8.31
ug/l
0.26
24
14
266
1695
1.94
14.86
3.0
2.3
58.18
59.71
u/l
0.16
251
1577
334
2296
1.90
14.79
5.7
4.3
34.56
35.81
g/l
3.75
319
2145
212
1254
2.01
14.67
1.9
1.6
1.13
1.06
mg/l
0.17
187
966
162
871
2.13
14.50
3.5
2.5
1.29
1.12
e6/l
0.17
111
470
25
20
12.93
14.48
2.6
2.7
—
—
—
0
0
343
2401
1.87
14.15
17.4
12.3
1.26
1.20
inr
0.66
103
708
26
48
5.59
13.63
2.3
1.5
47.81
62.94
%
1.01
21
33
135
696
2.17
13.36
2.2
2.2
225.11
121.29
ug/g
0.97
111
540
96
430
2.44
13.20
3.8
3.6
1.22
1.23
mmol/l
0.70
84
374
43
125
3.61
12.84
1.8
1.3
—
—
—
0
0
86
372
2.50
12.74
2.0
1.6
—
—
—
0
0
39
107
3.81
12.65
1.6
1.4
—
—
—
0
0
471
3714
1.89
12.64
5.7
4.3
653.83
3070.71
e6/l
—
6
59
148
810
2.06
12.46
4.3
2.7
5.17
3.59
e6/l
0.48
95
411
172
1005
1.95
12.00
1.9
1.7
997.76
1177.42
nmol/l
2.05
133
754
632
5606
3.00
11.89
30.0
12.6
17.06
21.96
mg/l
4.87
571
4376
38
107
3.70
11.89
1.9
1.7
6831.90
16831.45
e6/l
0.82
29
77
353
2581
1.77
11.85
3.7
2.7
141.47
100.67
ug/l
1.10
328
2387
24
27
9.17
11.83
1.3
1.1
1.11
1.12
ratio
—
12
9
16
7
23.36
11.61
2.3
3.0
—
—
—
0
0
32
82
4.05
11.41
1.3
1.4
110.40
114.62
u/ml
—
5
21
307
2175
1.75
11.34
2.1
2.0
93.02
95.96
pmol/l
0.52
169
1088
266
1813
1.77
11.22
4.1
2.9
33.53
29.84
u/l
1.35
255
1721
40
122
3.42
11.12
1.2
1.5
—
—
—
0
0
52
188
2.91
10.91
2.0
1.9
2.64
2.73
ug/l
0.02
46
169
33
90
3.80
10.81
1.1
1.3
297.20
258.17
u/ml
0.25
20
50
34
99
3.56
10.14
1.1
1.3
—
—
—
0
0
41
139
3.08
9.63
1.8
4.6
42.71
94.28
mg/l
0.57
35
110
41
139
3.08
9.63
1.8
4.6
37.19
49.50
mg/l
0.22
34
110
105
555
2.06
9.56
2.1
1.7
—
—
—
0
0
397
3116
1.67
9.35
5.3
4.5
6.41
6.61
mmol/l
1.08
380
2900
115
633
1.98
9.35
6.6
5.2
1.04
1.04
mmol/l
0.02
107
581
40
137
3.04
9.23
1.8
4.5
1.31
2.21
ratio
—
6
15
201
1328
1.73
9.08
1.4
1.3
0.99
2.18
u/ml
1.28
50
336
195
1280
1.74
9.01
1.6
1.5
21.95
21.41
nmol/l
0.17
163
1092
41
146
2.93
8.85
1.3
1.2
—
—
—
0
0
19
40
4.86
8.63
1.5
1.6
—
—
—
0
0
94
495
2.04
8.62
2.9
2.1
0.22
0.22
g/l
0.02
83
467
103
564
1.98
8.47
2.1
1.8
—
—
—
0
0
39
140
2.90
8.31
1.9
1.5
—
—
—
0
0
42
158
2.77
8.22
1.2
1.3
—
—
—
0
0
50
208
2.52
8.03
2.0
1.8
—
—
—
0
0
32
105
3.15
7.95
2.6
2.0
132.90
130.74
g/l
0.17
20
74
63
293
2.27
7.91
1.8
1.7
—
—
—
0
0
80
412
2.07
7.78
3.4
3.7
94.65
78.22
ng/l
0.37
71
364
42
165
2.65
7.57
1.5
1.4
305.22
300.06
ug/g
0.05
24
95
28
88
3.28
7.47
1.5
1.4
—
—
—
0
0
590
5284
1.93
7.45
21.8
11.8
84.48
82.23
ml/min/173m2
1.62
541
4302
35
126
2.88
7.43
1.3
1.4
—
—
—
0
0
19
35
5.55
6.96
2.1
1.4
49.25
40.39
%
0.36
13
23
254
1888
1.55
6.79
3.0
3.3
2.33
2.35
mmol/l
2.59
216
1668
68
347
2.07
6.78
1.4
1.2
60.76
192.30
u/ml
1.18
58
321
32
116
2.85
6.73
1.7
1.5
—
—
—
0
0
45
194
2.41
6.72
2.0
1.7
—
—
—
0
0
82
450
1.94
6.67
4.0
3.3
2.30
1.96
mmol/l
0.37
74
368
19
51
3.80
6.40
1.3
1.1
—
—
—
0
0
23
71
3.32
6.33
1.6
1.5
—
—
—
0
0
9
5
18.21
6.27
1.0
6.6
—
—
—
0
0
17
43
4.03
6.20
1.6
1.3
—
—
—
0
0
17
33
5.26
6.04
3.2
2.9
56.88
42.60
%
—
8
16
21
63
3.41
6.04
1.6
1.4
—
—
—
0
0
62
320
2.03
6.00
1.4
1.4
—
—
—
0
0
70
378
1.95
5.97
3.9
2.6
4.34
4.52
kpa
0.35
70
363
32
124
2.66
5.96
1.7
1.5
—
—
—
0
0
175
1225
1.58
5.96
7.4
3.8
1.01
1.02
kg/l
0.81
25
168
13
18
7.34
5.94
4.3
3.6
2435.38
739.83
u/ml
1.11
13
18
30
113
2.73
5.90
1.7
2.1
4.70
4.63
mmol/24h
0.03
24
95
163
1128
1.59
5.82
1.6
1.7
56000422.65
27292326.59
pmol/l
0.21
125
949
23
76
3.10
5.69
1.5
1.4
—
—
—
0
0
90
539
1.77
5.55
6.0
8.2
0.78
1.32
mmol/l
0.60
77
431
90
539
1.77
5.55
6.0
8.1
4.83
5.12
kpa
2.52
85
518
14
24
5.93
5.55
1.4
1.2
—
—
—
0
0
14
24
5.93
5.55
1.4
1.2
—
—
—
0
0
17
47
3.68
5.51
1.7
1.7
—
—
—
0
0
27
101
2.74
5.39
1.3
1.2
—
—
—
0
0
27
101
2.74
5.39
1.3
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
125
2.55
5.36
5.1
2.6
0.52
0.38
u/ml
0.64
22
74
25
90
2.85
5.36
1.8
1.6
—
—
—
0
0
21
69
3.11
5.26
1.3
1.3
—
—
—
0
0
32
133
2.48
5.21
1.2
1.3
—
—
—
0
0
11
16
6.97
4.97
1.1
1.4
—
—
—
0
0
97
613
1.68
4.94
2.2
2.4
6.31
7.05
umol/l
0.20
85
525
16
38
4.29
4.85
1.3
1.0
—
—
—
0
0
55
295
1.94
4.81
4.8
3.6
1.82
1.97
mmol/l
0.10
42
223
543
4909
1.54
4.73
31.0
15.2
15.56
14.82
%
2.03
538
4836
506
4511
1.49
4.69
5.1
4.1
14.85
14.70
pmol/l
0.72
461
4115
184
1363
1.48
4.69
4.7
3.4
94.82
94.09
%
0.15
179
1331
17
53
3.26
4.64
1.8
1.6
—
—
—
0
0
23
86
2.73
4.62
1.3
1.1
—
—
—
0
0
11
18
6.19
4.62
2.1
1.3
2.40
1.40
%
—
5
5
632
5951
1.97
4.59
24.4
9.7
25.47
24.60
u/l
0.91
621
5740
138
967
1.54
4.58
4.4
3.7
297.42
295.03
ng/l
0.00
109
709
30
132
2.33
4.35
1.0
1.1
—
—
—
0
0
22
84
2.67
4.27
1.1
1.2
—
—
—
0
0
16
51
3.19
4.23
5.4
3.9
—
—
—
0
0
15
46
3.31
4.21
1.1
1.5
—
—
—
0
0
15
46
3.31
4.21
1.1
1.5
—
—
—
0
0
15
46
3.31
4.21
1.1
1.5
—
—
—
0
0
19
68
2.85
4.15
1.1
1.1
—
—
—
0
0
122
852
1.53
4.09
3.3
3.1
0.79
0.82
mmol/l
1.59
111
796
13
31
4.26
4.03
1.2
1.1
—
—
—
0
0
14
36
3.95
4.01
2.0
2.7
—
—
—
0
0
24
99
2.48
4.01
1.2
1.5
—
—
—
0
0
9
14
6.50
3.99
1.9
1.6
—
—
—
0
0
21
82
2.61
3.92
1.4
1.4
—
—
—
0
0
14
37
3.84
3.91
1.1
1.0
—
—
—
0
0
8
11
7.34
3.87
1.1
1.4
—
—
—
0
0
8
12
6.73
3.68
1.1
1.2
—
—
—
0
0
21
85
2.52
3.66
1.4
1.5
—
—
—
0
0
21
85
2.52
3.66
1.4
1.5
—
—
—
0
0
607
5705
1.64
3.66
23.4
14.6
139.35
139.65
mmol/l
1.87
595
5551
18
68
2.69
3.59
4.8
2.4
4.06
4.00
mmol/l
0.21
18
68
18
68
2.69
3.59
4.8
2.4
107.00
105.88
mmol/l
0.65
18
68
11
26
4.28
3.52
1.6
1.1
—
—
—
0
0
17
63
2.74
3.51
1.2
1.1
—
—
—
0
0
607
5724
1.60
3.37
23.5
14.7
3.93
3.95
mmol/l
1.23
592
5554
174
1348
1.39
3.35
2.7
2.2
—
—
—
0
0
10
24
4.21
3.20
1.2
1.0
—
—
—
0
0
311
2649
1.32
3.19
2.9
2.5
—
—
—
0
0
19
80
2.41
3.08
1.3
1.4
—
—
—
0
0
19
80
2.41
3.08
1.3
1.4
—
—
—
0
0
19
81
2.38
3.01
1.3
1.3
—
—
—
0
0
19
81
2.38
3.01
1.3
1.4
—
—
—
0
0
19
82
2.36
2.93
1.3
1.4
—
—
—
0
0
12
38
3.20
2.86
1.5
1.1
—
—
—
0
0
15
59
2.58
2.80
2.3
1.6
—
—
—
0
0
20
91
2.23
2.76
3.6
2.3
16.97
16.00
%
0.43
12
43
35
197
1.82
2.73
1.9
1.7
—
—
—
0
0
10
29
3.48
2.70
1.1
1.5
—
—
—
0
0
10
29
3.48
2.70
1.1
1.5
—
—
—
0
0
63
419
1.56
2.66
2.3
2.3
7.28
7.02
ug/l
0.04
46
363
40
237
1.73
2.64
2.8
3.1
24.61
24.09
mmol/l
0.50
40
230
94
681
1.44
2.63
4.9
4.3
33.14
32.77
%
0.11
74
452
12
41
2.96
2.63
1.9
1.6
—
—
—
0
0
6
11
5.49
2.55
1.0
1.0
—
—
—
0
0
34
195
1.78
2.51
5.3
4.0
24.56
25.01
mmol/l
0.40
29
188
28
151
1.89
2.50
1.2
1.2
—
—
—
0
0
11
37
3.00
2.49
1.8
1.4
1.80
1.97
mmol/l
0.86
11
37
30
512
0.57
2.45
1.9
1.7
—
—
—
0
0
9
27
3.36
2.40
1.2
1.2
—
—
—
0
0
5
8
6.29
2.37
1.0
1.0
—
—
—
0
0
10
33
3.06
2.36
2.1
1.4
—
—
—
0
0
40
246
1.67
2.33
3.4
2.2
1.06
1.22
%
0.71
40
246
9
28
3.24
2.31
2.2
1.4
—
—
—
0
0
9
29
3.13
2.23
2.2
1.4
—
—
—
0
0
5
9
5.59
2.21
1.0
1.4
—
—
—
0
0
11
41
2.71
2.21
1.6
1.2
6183.33
54734.57
e6/l
—
6
21
54
364
1.53
2.18
2.7
3.3
4.23
4.55
pmol/l
1.09
45
316
16
74
2.19
2.16
2.0
1.5
—
—
—
0
0
7
19
3.71
2.15
1.3
1.5
—
—
—
0
0
403
3662
1.25
2.12
3.2
3.2
—
—
—
0
0
5
10
5.03
2.07
1.2
1.1
88.00
102.20
%
—
5
10
7
20
3.53
2.06
1.1
1.7
—
—
—
0
0
7
20
3.53
2.06
1.1
1.7
—
—
—
0
0
7
20
3.53
2.06
1.1
1.7
—
—
—
0
0
26
147
1.80
2.05
1.9
1.2
620.27
462.17
mg/l
0.70
26
139
5
11
4.57
1.94
1.2
1.2
—
—
—
0
0
6
16
3.77
1.94
1.0
1.1
—
—
—
0
0
6
16
3.77
1.94
1.0
1.3
—
—
—
0
0
187
1574
1.26
1.91
4.6
3.8
15.56
8.33
mg/mmol
0.59
129
968
405
3709
1.23
1.88
4.2
3.0
52.49
45.59
u/l
0.78
379
3471
5
12
4.19
1.82
1.0
1.1
—
—
—
0
0
7
24
2.94
1.72
1.0
1.5
—
—
—
0
0
67
501
1.37
1.62
2.3
2.2
31.42
34.55
u/l
0.33
57
410
13
63
2.08
1.60
1.0
1.2
—
—
—
0
0
7
26
2.71
1.58
1.3
1.2
—
—
—
0
0
7
26
2.71
1.58
1.3
1.2
—
—
—
0
0
8
33
2.44
1.54
1.0
1.2
—
—
—
0
0
555
5302
1.26
1.53
6.3
4.9
1.95
2.10
mu/l
0.28
513
4863
12
58
2.09
1.50
1.2
1.4
346.00
397.74
pmol/l
0.15
12
53
6
22
2.74
1.43
2.8
3.0
49500.00
37400.23
ug/l
—
6
22
16
89
1.82
1.38
1.0
1.1
—
12.59
—
0
7
8
34
2.37
1.29
1.1
1.1
—
—
—
0
0
12
62
1.95
1.28
1.2
1.1
—
—
—
0
0
60
460
1.33
1.27
1.2
1.2
68.25
137.97
iu/ml
1.83
20
193
184
1614
1.19
1.23
3.8
3.0
6.80
7.18
mmol/l
0.56
151
1362
14
78
1.81
1.22
1.1
1.1
—
—
—
0
0
5
19
2.64
1.22
1.6
1.7
70.74
50.70
ug/l
—
5
19
638
6242
1.40
1.21
41.3
19.0
255.66
255.47
e9/l
0.02
629
6092
11
57
1.95
1.17
1.7
1.4
—
—
—
0
0
11
57
1.95
1.17
1.7
1.4
—
—
—
0
0
638
6246
1.39
1.16
41.1
19.0
4.35
4.45
e12/l
6.35
627
6076
638
6248
1.39
1.13
41.4
19.1
130.47
133.80
g/l
8.12
630
6153
7
140
0.49
1.10
2.0
1.7
—
—
—
0
0
637
6241
1.37
1.08
41.2
19.0
39.30
39.85
%
1.63
606
5866
7
32
2.20
1.08
1.3
1.3
—
—
—
0
0
7
32
2.20
1.08
1.3
1.3
—
—
—
0
0
129
1112
1.20
1.05
1.4
1.5
—
—
—
0
0
119
1019
1.20
1.04
2.8
2.7
2.46
2.44
mmol/l
0.62
106
903
26
180
1.46
1.02
1.3
1.2
—
—
—
0
0
9
154
0.58
0.89
1.3
1.6
—
—
—
0
0
68
560
1.24
0.88
4.0
3.0
—
—
—
0
0
75
625
1.23
0.87
1.4
1.7
1.67
1.41
%
1.00
67
552
21
145
1.46
0.85
1.9
1.8
3.97
5.18
iu/l
—
7
46
54
436
1.26
0.84
5.5
2.4
63.88
68.34
ml/min/173m2
0.33
26
177
6
33
1.83
0.79
1.3
1.4
—
24.00
—
0
5
25
182
1.39
0.79
1.3
1.2
—
—
—
0
0
6
34
1.77
0.76
1.0
1.4
—
275.00
—
0
6
9
54
1.68
0.74
1.2
1.1
—
—
—
0
0
11
172
0.63
0.74
1.4
1.5
—
—
—
0
0
44
543
0.80
0.73
2.2
2.9
1.02
0.78
ug/l
0.35
26
359
132
1182
1.15
0.69
1.5
1.4
—
—
—
0
0
134
1487
0.88
0.68
1.6
1.6
1.37
1.38
mmol/l
0.03
113
1267
5
28
1.79
0.66
2.0
2.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
36
1.67
0.57
1.0
1.1
—
—
—
0
0
6
37
1.63
0.55
1.0
2.0
—
—
—
0
0
6
38
1.58
0.54
1.0
1.3
—
—
—
0
0
26
322
0.80
0.49
1.6
1.5
—
—
—
0
0
553
5634
0.90
0.48
4.8
4.8
2.61
2.80
mmol/l
6.55
517
5215
7
47
1.49
0.47
1.3
1.3
—
—
—
0
0
7
48
1.46
0.47
1.0
1.5
13.84
20.50
ug/l
—
7
48
5
84
0.59
0.45
1.4
1.3
3.73
3.00
ug/l
—
5
72
17
220
0.77
0.45
1.6
1.5
—
—
—
0
0
5
31
1.62
0.43
1.4
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
2.30
—
0
6
5
34
1.47
0.40
3.6
1.4
1.20
1.40
promille
—
5
25
19
237
0.80
0.39
1.6
1.4
—
—
—
0
0
39
335
1.17
0.39
1.4
1.3
—
—
—
0
0
14
181
0.77
0.38
1.6
1.4
—
—
—
0
0
14
181
0.77
0.38
1.6
1.4
—
—
—
0
0
14
181
0.77
0.38
1.6
1.4
—
—
—
0
0
14
181
0.77
0.38
1.6
1.4
—
—
—
0
0
8
114
0.70
0.37
1.3
1.5
—
—
—
0
0
5
37
1.35
0.37
1.2
2.1
745.60
536.77
ml
—
5
22
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
16
198
0.80
0.32
1.6
1.9
—
—
—
0
0
519
5102
1.07
0.32
5.8
5.5
38.72
39.36
mmol/mol
0.96
479
4738
35
310
1.14
0.26
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.2
1.3
81.20
75.25
umol/l
—
5
40
536
5297
1.06
0.22
4.2
3.8
1.30
1.26
mmol/l
0.73
494
4866
8
101
0.79
0.21
1.5
1.7
—
—
—
0
0
66
707
0.93
0.21
1.8
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
1.19
—
0
14
34
308
1.11
0.19
1.2
1.2
36.25
29.23
iu/l
0.45
27
259
6
52
1.16
0.19
4.7
2.4
—
—
—
0
0
44
405
1.09
0.19
1.5
1.8
—
—
—
0
0
18
205
0.87
0.17
1.2
1.3
383.34
264.38
miu/ml
—
7
99
98
935
1.06
0.17
3.8
4.8
1.28
2.47
ug/l
2.53
82
833
17
194
0.87
0.17
1.7
1.5
—
—
—
0
0
70
740
0.94
0.16
2.7
4.3
24.02
21.47
%
0.75
28
345
22
246
0.89
0.16
1.8
2.1
118.44
2387.93
u/l
—
9
102
8
69
1.16
0.16
1.0
1.0
—
—
—
0
0
8
72
1.11
0.16
1.1
1.1
—
—
—
0
0
26
235
1.11
0.16
1.3
1.4
—
—
—
0
0
546
5503
0.96
0.14
4.6
4.2
1.50
1.52
mmol/l
0.45
507
5099
8
100
0.80
0.13
1.5
1.5
—
—
—
0
0
546
5420
1.04
0.12
4.7
4.4
5.65
5.87
mmol/l
3.91
493
4959
30
324
0.92
0.12
1.5
1.7
—
—
—
0
0
61
640
0.95
0.12
1.5
1.9
—
—
—
0
0
70
678
1.04
0.08
8.9
6.4
—
—
—
0
0
7
80
0.87
0.07
1.3
1.3
0.47
0.55
nmol/l
—
7
75
13
118
1.10
0.07
1.9
2.2
729.43
111.07
ug/min
—
7
70
551
5534
0.98
0.07
4.5
4.3
4.53
4.74
mmol/l
6.25
513
5152
11
101
1.09
0.04
1.3
1.1
0.68
2.93
u/ml
—
5
51
20
190
1.05
0.04
1.3
3.1
30.00
940.09
u/ml
0.68
15
163
55
538
1.02
0.03
2.7
3.9
2.93
17.68
ug/l
1.17
49
441
12
114
1.05
0.00
2.8
3.9
21.80
30.47
mg/l
—
5
71
24
246
0.97
0.00
1.9
2.0
11.99
12.31
nmol/l
0.07
19
224
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
84.39
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
0.50
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_OVERLAP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OVERLAP | 1.678 [1.46, 1.93] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 518 out of 2397 females with M13_OVERLAP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OVERLAP | 1.774 [1.42, 2.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 661 males with M13_OVERLAP died.
Mortality risk
Mortality risk for people of age
years, who have M13_OVERLAP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.263% |
| 5 | 1.046% | 1.899% |
| 10 | 2.575% | 4.915% |
| 15 | 4.769% | 8.96% |
| 20 | 8.273% | 15.286% |
Relationships between endpoints
↥Index endpoint: M13_OVERLAP – Other overlap syndromes
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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