Mixed connective tissue disease

M13_MCTD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M35.9
  • Hospital discharge: ICD-9 7109
  • Hospital discharge: ICD-8 73499
  • Cause of death: ICD-10 M35.9
  • Cause of death: ICD-9 7109
  • Cause of death: ICD-8 73499

2 out of 7 registries used, show all original rules.

1994

4. Check minimum number of events

None

1994

5. Include endpoints

2492

6. Filter based on genotype QC (FinnGen only)

2492

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14204 11040 3044
Only index persons 12490 9991 2499
Unadjusted period prevalence (%)
Whole population 0.27 0.32 0.09
Only index persons 0.31 0.37 0.10
Median age at first event (years)
Whole population 54.56 53.37 58.70
Only index persons 52.81 51.86 56.64

-FinnGen-

Key figures

All Female Male
Number of individuals 2492 1994 498
Unadjusted period prevalence (%) 0.59 0.68 0.22
Median age at first event (years) 51.54 49.85 58.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2271
Matched controls
22707
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
323.0
607
*
P01BA02
ATC
hydroxychloroquine; oral
35.5
323.0
1406
992
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
8231.9
323.0
1741
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
19.4
323.0
1236
1315
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
35.0
323.0
518
190
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
9.5
318.0
733
1082
H02AB06
ATC
prednisolone; systemic
5.8
313.1
1714
7843
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.3
312.9
644
770
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
89.9
275.8
305
39
L04AX01
ATC
azathioprine; systemic
14.1
247.2
445
386
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
199.4
1229
5232
C08CA05
ATC
nifedipine; systemic
7.9
175.4
437
667
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.1
166.5
449
766
I73.0
ICD-10 Finland
Raynaud syndrome
19.8
162.9
252
142
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
146.7
1264
6417
XPX04
NOMESCO Finland
Angioscopy
66.4
134.1
155
25
XX9XE
NOMESCO Finland
Other ultrasound examination
29.3
123.8
169
62
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.8
113.3
418
1010
H02AB07
ATC
prednisone; oral
3.7
112.3
578
1906
L88
ICPC
Rheumatoid/seropositive arthritis
8.1
109.7
262
361
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
7.1
103.1
269
422
L04AA06
ATC
mycophenolic acid; systemic
17.7
99.9
160
97
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.7
94.7
201
226
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.8
92.4
338
798
M05BA04
ATC
alendronic acid; oral
4.5
92.4
364
927
M35.3
ICD-10 Finland
Polymyalgia rheumatica
7.5
91.3
227
330
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.2
89.4
256
453
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
55.5
89.2
106
20
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
86.8
846
4193
M34.1
ICD-10 Finland
CR(E)ST syndrome
43.2
86.0
107
26
7109X
ICD-9 Finland
Diffuse diseases of connective tissue, Unspecified diffuse connective tissue disease
+∞
83.9
80
*
M13.9
ICD-10 Finland
Arthritis, unspecified
4.5
76.8
300
750
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.9
72.4
254
567
SBA10
NOMESCO Finland
Measurement of excretion of saliva
15.3
71.9
121
83
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
71.3
1135
7019
R50.9
ICD-10 Finland
Fever, unspecified
3.1
71.3
453
1684
M25.5
ICD-10 Finland
Pain in joint
2.4
71.1
846
4546
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
20.9
70.7
106
53
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
75.5
70.6
80
11
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.6
69.9
218
425
A02BC02
ATC
pantoprazole; systemic
2.2
65.6
1596
11731
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
65.6
334
1049
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
118.5
64.2
69
6
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
62.3
371
1306
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
135.8
62.2
66
5
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
7.9
58.4
138
184
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
58.2
552
2588
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.3
54.5
300
990
PAW37
NOMESCO Finland
Biopsy of temporal artery
20.9
54.3
81
40
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
100.9
54.1
59
6
ZX120
NOMESCO Finland
Intravenous
3.2
52.5
312
1090
R06.0
ICD-10 Finland
Dyspnoea
2.2
51.1
644
3440
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
93.9
50.0
55
6
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.9
49.0
213
580
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
6.0
48.0
138
242
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.4
46.9
148
291
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
46.6
297
1084
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
45.4
268
928
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
45.3
488
2398
R4120
NOMESCO Finland
Occupational therapy
3.6
45.1
223
675
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
8.9
44.8
98
115
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
44.5
590
3188
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.0
44.1
127
223
UJF32
NOMESCO Finland
Coloscopy
2.1
43.8
646
3648
N03AX16
ATC
pregabalin; oral
2.1
43.0
622
3483
L04AD01
ATC
ciclosporin; systemic
8.5
43.0
96
117
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
42.8
530
2773
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
44.3
42.3
52
12
E0000UV
ATC
NA
1.9
41.8
982
6587
N02AX02
ATC
tramadol; systemic, rectal
1.9
41.7
994
6698
XG410
NOMESCO Finland
Flow-volume spirometry
4.5
41.2
153
358
A02BC03
ATC
lansoprazole; oral
1.9
40.9
746
4559
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
40.4
366
1640
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
39.9
526
2817
M05BA07
ATC
risedronic acid; oral
4.6
38.1
137
310
H02AB04
ATC
methylprednisolone; systemic
2.3
38.1
408
1983
M34.0
ICD-10 Finland
Progressive systemic sclerosis
72.8
38.0
43
6
A07EC01
ATC
sulfasalazine; oral, rectal
2.9
37.6
248
921
M33.2
ICD-10 Finland
Polymyositis
62.5
37.2
43
7
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.5
36.6
112
212
TGC00
NOMESCO Finland
Bronchial lavation
6.1
36.3
102
174
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
35.7
396
1950
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.4
35.6
187
592
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.6
35.4
106
196
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
5.9
35.2
101
177
J01FF01
ATC
clindamycin; systemic
1.9
34.8
656
4007
TEA00
NOMESCO Finland
Biopsy of lip
8.9
33.9
73
84
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
33.7
202
701
M01AH01
ATC
celecoxib; oral (coxibs)
2.1
33.6
474
2587
R51.80
ICD-10 Finland
Headache
2.2
33.5
388
1944
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
10.8
33.4
65
62
C03CA01
ATC
furosemide; systemic
1.9
33.4
592
3528
L93.0
ICD-10 Finland
Discoid lupus erythematosus
14.7
33.3
56
39
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
8.6
33.2
73
87
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
41.7
33.1
41
10
M79.7
ICD-10 Finland
Fibromyalgia
3.8
32.5
142
387
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
32.4
337
1604
NXL00
NOMESCO Finland
Biopsy of muscle
26.3
31.9
44
17
M35
ICD-10 Finland
Other systemic involvement of connective tissue
167.3
31.8
33
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
31.7
294
1322
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
31.6
923
6455
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
4.5
31.5
115
265
J01MA12
ATC
levofloxacin; systemic
2.1
31.5
429
2301
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
5.5
31.3
95
179
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
5.9
31.1
89
156
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
30.8
312
1465
J01DB01
ATC
cefalexin; oral
1.8
30.0
1838
15845
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
41.7
30.0
37
9
A02BC01
ATC
omeprazole; systemic
1.8
29.8
660
4214
L04AA13
ATC
leflunomide; oral
4.3
29.5
112
268
N03AX12
ATC
gabapentin; oral
2.1
29.1
393
2093
A02BC05
ATC
esomeprazole; systemic
1.7
29.0
948
6796
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
40.6
29.0
36
9
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
6.8
28.6
73
110
M32
ICD-10 Finland
Systemic lupus erythematosus
55.7
28.2
33
6
A07AA02
ATC
nystatin; oral
2.8
28.1
189
706
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
78.6
27.8
31
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
27.6
599
3784
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.4
27.6
142
442
ELA30
NOMESCO Finland
Biopsy of salivary gland
25.7
27.5
38
15
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
27.5
237
1021
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
27.3
674
4428
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.3
27.3
145
462
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
27.2
265
1217
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
27.0
146
471
M35.7
ICD-10 Finland
Hypermobility syndrome
6.3
27.0
73
119
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
26.6
240
1058
C08CA02
ATC
felodipine; oral
2.5
26.6
229
986
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.9
26.5
88
184
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.5
26.4
128
380
M05BX04
ATC
denosumab; parenteral
3.1
26.4
151
507
L99
ICPC
Musculoskeletal disease other
5.3
26.4
82
159
C08CA01
ATC
amlodipine; oral
1.7
26.0
716
4847
L04AA01
ATC
[U] ciclosporin; systemic
6.0
25.9
73
126
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
25.4
202
834
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
25.3
880
6343
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
25.2
383
2127
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
24.9
238
1081
J02AC01
ATC
fluconazole; systemic
1.6
24.8
1034
7802
D68.8
ICD-10 Finland
Other specified coagulation defects
7.7
24.1
56
74
ZX140
NOMESCO Finland
Intra articular
9.0
24.0
51
58
N02BE01
ATC
paracetamol; systemic, rectal
1.8
23.7
1938
17319
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
7.5
22.9
54
73
M01AC06
ATC
meloxicam; systemic, rectal
1.6
22.9
863
6309
N06AX21
ATC
duloxetine; oral
2.1
22.8
286
1466
WZA10
NOMESCO Finland
Long statement of health and health related matters
5.9
22.7
64
111
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
84.3
22.7
25
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
22.7
196
844
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
12.7
22.6
40
32
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
22.4
404
2381
M33.1
ICD-10 Finland
Other dermatomyositis
45.5
22.4
27
6
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
22.2
212
959
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
4.5
22.2
80
183
M60.9
ICD-10 Finland
Myositis, unspecified
12.8
22.1
39
31
D07AC01
ATC
betamethasone; topical
1.6
22.1
746
5288
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
22.0
819
5947
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
21.8
117
376
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.2
21.8
85
210
A02BA02
ATC
ranitidine; systemic
1.8
21.1
444
2743
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
28.3
20.9
28
10
J01MA02
ATC
ciprofloxacin; systemic
1.6
20.9
799
5819
E000001
ATC
NA
1.7
20.9
469
2958
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
20.8
243
1209
A01AB09
ATC
miconazole; local oral
2.2
20.8
229
1108
J01DA01
ATC
[U] cefalexin; systemic
1.5
20.7
1396
11596
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
20.6
737
5281
J01AA02
ATC
doxycycline; systemic
1.6
20.5
1732
15150
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
20.5
335
1901
C07AB07
ATC
bisoprolol; oral
1.5
20.3
927
7033
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
20.2
413
2528
N06AA09
ATC
amitriptyline; systemic
2.1
20.2
259
1340
P01BA01
ATC
chloroquine; systemic
8.9
19.9
42
48
73499
ICD-8 Finland
Diffuse diseases of connective tissue, Other and unspecified
+∞
19.8
19
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.2
19.8
107
347
J01MA14
ATC
moxifloxacin; systemic
2.2
19.7
215
1036
M79.6
ICD-10 Finland
Pain in limb
1.6
19.7
791
5811
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
74.1
19.7
22
*
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
12.2
19.6
35
29
G04BE03
ATC
sildenafil; oral
8.2
19.5
43
53
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
19.3
363
2158
XW000
NOMESCO Finland
Bone marrow biopsy
3.2
19.3
103
331
I77.6
ICD-10 Finland
Arteritis, unspecified
22.7
19.1
27
12
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
19.0
993
7728
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.5
19.0
160
681
S18
ICPC
Laceration/cut
1.5
18.9
856
6448
R03AC02
ATC
salbutamol; inhalant
1.5
18.9
1174
9482
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
18.8
172
764
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
18.8
18
*
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
8.3
18.7
41
50
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
18.7
181
824
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.5
18.7
87
252
M01AH02
ATC
rofecoxib; oral
1.9
18.6
317
1821
M79.1
ICD-10 Finland
Myalgia
1.9
18.6
303
1714
S01XA18
ATC
ciclosporin; ophthalmic
9.4
18.6
38
41
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
4.9
18.5
61
128
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.3
18.3
177
807
R13
ICD-10 Finland
Dysphagia
2.5
18.3
151
634
J01FA06
ATC
roxithromycin; oral
1.5
18.1
900
6908
K90.0
ICD-10 Finland
Coeliac disease
3.4
17.9
87
261
M01AH05
ATC
etoricoxib; oral
1.5
17.8
1297
10770
7102A
ICD-9 Finland
Diffuse diseases of connective tissue, Sicca syndrome[SYNDROMA SICCUM PRIMARIUM]
+∞
17.7
17
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
11.1
17.7
33
30
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
17.7
247
1320
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
181.3
17.5
18
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
17.5
392
2455
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
17.4
339
2033
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
17.1
86
265
R06AE07
ATC
cetirizine; oral
1.5
17.0
991
7829
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.9
17.0
104
367
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.4
16.8
81
242
TNG10
NOMESCO Finland
Puncture of knee
5.5
16.8
49
90
J05AB11
ATC
valaciclovir; oral
1.8
16.7
304
1783
J01EA01
ATC
trimethoprim; systemic
1.6
16.6
596
4223
L20
ICPC
Joint symptom/complaint NOS
2.9
16.6
101
355
ZXA00
NOMESCO Finland
Right side
1.6
16.5
550
3829
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
16.5
271
1536
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
16.4
187
916
R07.3
ICD-10 Finland
Other chest pain
2.0
16.4
209
1076
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
40.4
16.3
20
5
R4110
NOMESCO Finland
Physiotherapy
1.6
16.3
550
3838
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
16.3
173
825
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.1
16.2
192
959
R53
ICD-10 Finland
Malaise and fatigue
1.6
16.2
439
2900
R76.0
ICD-10 Finland
Raised antibody titre
12.9
16.1
28
22
318
Kela drug reimbursment
Teriparatide
8.6
15.9
34
40
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.3
15.9
150
676
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
15.9
248
1380
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
15.8
935
7378
H26.3
ICD-10 Finland
Drug-induced cataract
8.4
15.7
34
41
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
15.7
534
3731
R1250
NOMESCO Finland
Evaluation of functional capability
3.7
15.6
68
187
UJF30
NOMESCO Finland
Ileoscopy through colon
2.0
15.6
213
1129
H02AB09
ATC
hydrocortisone; systemic
3.6
15.5
70
199
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.4
15.5
74
220
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
3.0
15.5
89
302
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
9.5
15.4
31
33
M81.4
ICD-10 Finland
Drug-induced osteoporosis
12.4
15.3
27
22
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.6
15.3
53
118
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.4
15.3
133
577
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
15.3
158
743
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
5.1
15.2
47
93
L50.9
ICD-10 Finland
Urticaria, unspecified
2.8
15.1
101
376
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.8
15.1
305
1846
K74.3
ICD-10 Finland
Primary biliary cirrhosis
8.1
15.0
33
41
M01AE02
ATC
naproxen; oral, rectal
1.4
14.9
1224
10234
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
14.9
254
1453
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
14.9
243
1370
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.5
14.9
70
206
XF402
NOMESCO Finland
ECG with work load test
1.9
14.9
225
1238
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
4.6
14.8
51
113
B01AB05
ATC
enoxaparin; parenteral
1.5
14.8
624
4569
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
57.0
14.8
17
*
M54.5
ICD-10 Finland
Low back pain
1.5
14.7
706
5316
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.3
14.7
139
627
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.2
14.7
150
704
A02BX02
ATC
sucralfate; oral
2.6
14.6
109
434
J05AB01
ATC
aciclovir; systemic
1.6
14.4
474
3274
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
6.2
14.4
38
62
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
14.4
143
663
R52.2
ICD-10 Finland
Other chronic pain
2.8
14.2
92
337
XF404
NOMESCO Finland
Ambulatory ECG
2.0
14.1
189
993
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.5
14.0
66
195
D70.89
ICD-10 Finland
Neutropenic splenomegaly
5.6
13.9
40
73
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
3.7
13.9
60
165
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
12.7
13.9
24
19
R00.2
ICD-10 Finland
Palpitations
2.0
13.9
173
882
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
11.5
13.8
25
22
H05AA02
ATC
teriparatide; parenteral
8.2
13.8
30
37
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
13.8
306
1906
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.2
13.7
145
687
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
10.5
13.7
26
25
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
13.7
1497
13098
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
13.6
167
845
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.6
13.5
99
390
L01AA01
ATC
cyclophosphamide; systemic
10.1
13.5
26
26
A01
ICPC
Pain general/multiple sites
2.0
13.4
172
886
SBB10
NOMESCO Finland
Teeth copy
2.2
13.4
136
634
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
13.4
100
400
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
13.4
252
1490
M31.1
ICD-10 Finland
Thrombotic microangiopathy
25.9
13.4
18
7
M01AX17
ATC
nimesulide; oral
1.5
13.3
517
3701
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
2.7
13.3
90
339
B01AA03
ATC
warfarin; systemic
1.7
13.3
326
2087
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
13.3
353
2309
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
13.3
309
1950
L17
ICPC
Foot/toe symptom/complaint
1.5
13.2
521
3746
TAB00
NOMESCO Finland
Lumbar puncture
2.4
13.2
113
485
N02AA05
ATC
oxycodone; systemic
1.7
13.1
271
1648
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.5
13.1
105
437
M13.0
ICD-10 Finland
Polyarthritis, unspecified
4.4
13.1
46
105
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
13.0
187
1007
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
13.0
229
1323
RS221
NOMESCO Finland
NA
4.8
13.0
42
88
WX110
NOMESCO Finland
Local anesthesy
1.4
13.0
1456
12725
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
13.0
200
1107
A01AB04
ATC
amphotericin B; local oral
2.3
12.9
122
549
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
4.7
12.9
43
93
AN1
HP
Coronary angiography
1.9
12.9
199
1100
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.1
12.9
155
780
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
12.8
341
2225
K11.2
ICD-10 Finland
Sialoadenitis
2.6
12.8
91
353
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
12.8
561
4123
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.9
12.7
79
283
S97
ICPC
Chronic ulcer skin
2.4
12.7
108
464
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
12.7
230
1344
M48.0
ICD-10 Finland
Spinal stenosis
1.8
12.6
229
1338
WX002
NOMESCO Finland
Sedation and analgesia
1.6
12.6
399
2727
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
32.2
12.6
16
5
286
Kela drug reimbursment
Ciclosporin eye drop
32.2
12.6
16
5
N35.9
ICD-10 Finland
Urethral stricture, unspecified
7.1
12.6
30
43
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
12.5
249
1499
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
12.5
768
6023
K11.70
ICD-10 Finland
Hypoptyalism
7.3
12.5
29
40
73491
ICD-8 Finland
Diffuse diseases of connective tissue, Collagenosis NUD
24.4
12.5
17
7
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
130.7
12.4
13
*
N02AC04
ATC
dextropropoxyphene; oral
2.7
12.4
85
322
J01CA04
ATC
amoxicillin; systemic
1.4
12.4
1753
15903
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.9
12.4
50
130
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.2
12.4
121
554
M05BA06
ATC
ibandronic acid; systemic
3.3
12.3
62
194
5BA08
NOMESCO Finland
NA
7.1
12.3
29
41
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
12.3
380
2576
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
12.2
317
2055
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
12.2
210
1204
J01FA10
ATC
azithromycin; systemic
1.4
12.2
1267
10867
Z01.9
ICD-10 Finland
Special examination, unspecified
2.2
12.2
127
601
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
12.1
154
792
-1
NOMESCO Finland
NA
1.4
12.1
681
5251
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
12.1
209
1204
A46
ICD-10 Finland
Erysipelas
1.7
12.0
244
1475
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
12.0
347
2313
G44.2
ICD-10 Finland
Tension-type headache
1.6
12.0
304
1959
D07AB08
ATC
desonide; topical
1.8
12.0
224
1322
M01CB03
ATC
auranofin; oral
5.1
12.0
37
74
NH3AE
NOMESCO Finland
Feet ultrasound examination
10.1
12.0
23
23
H03AA01
ATC
levothyroxine sodium; systemic
1.5
12.0
542
4003
L28
ICPC
Limited function/disability (L)
1.6
11.9
302
1945
A05AA02
ATC
ursodeoxycholic acid; oral
3.7
11.8
50
136
EB1BA
NOMESCO Finland
Extensive intraoral X-ray examination
9.7
11.7
23
24
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
2.5
11.7
89
361
R42
ICD-10 Finland
Dizziness and giddiness
1.5
11.6
435
3080
C02KX04
ATC
macitentan; oral
30.2
11.6
15
5
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
65.3
11.6
13
*
AA1AD
NOMESCO Finland
CT of head and brain
1.5
11.6
437
3099
ELB10
NOMESCO Finland
Excision of minor salivary gland
8.6
11.5
24
28
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
4.1
11.5
44
110
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.9
11.5
163
875
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
11.5
273
1731
L87.1
ICD-10 Finland
Reactive perforating collagenosis
+∞
11.5
11
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.6
11.5
50
140
M01AX01
ATC
nabumetone; oral
2.3
11.5
110
502
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
11.4
260
1625
UJF92
NOMESCO Finland
Capsular endoscopy
3.5
11.4
53
156
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
11.4
739
5831
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.9
11.4
170
929
M01AB55
ATC
diclofenac, combinations; oral
2.0
11.4
154
810
1XC02
NOMESCO Finland
NA
6.1
11.3
30
50
I27.0
ICD-10 Finland
Primary pulmonary hypertension
11.9
11.3
20
17
M02AA07
ATC
piroxicam; topical
1.4
11.3
747
5908
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
11.3
393
2739
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
10.6
11.3
21
20
L30.8
ICD-10 Finland
Other specified dermatitis
3.5
11.2
52
153
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
11.2
169
929
L95
ICPC
Osteoporosis
2.6
11.2
78
301
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
5.9
11.2
30
51
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
11.2
254
1586
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.7
11.2
47
128
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
7.6
11.1
25
33
M35.2
ICD-10 Finland
Behçet disease
25.1
11.1
15
6
C02KX01
ATC
bosentan; oral
25.1
11.1
15
6
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
4.9
11.1
35
72
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.1
11.1
42
104
R05
ICD-10 Finland
Cough
1.5
11.1
396
2773
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
6.4
11.1
28
44
N03AE01
ATC
clonazepam; systemic
2.1
11.0
129
643
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
11.0
210
1244
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
11.0
498
3665
D07AD01
ATC
clobetasol; topical
1.6
11.0
319
2130
J45.1
ICD-10 Finland
Nonallergic asthma
1.9
10.9
151
804
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
10.8
662
5154
M25.9
ICD-10 Finland
Joint disorder, unspecified
4.5
10.8
37
83
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
4.5
10.8
37
83
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.1
10.8
125
620
E000006
ATC
NA
1.9
10.8
160
873
SPAT1229
SPAT
Assessment of need for aid
1.9
10.8
156
843
EBA10
NOMESCO Finland
Surgical removal of tooth
1.7
10.6
230
1417
SBA00
NOMESCO Finland
Microbiological examinations
2.9
10.6
62
216
N05CF01
ATC
zopiclone; oral
1.4
10.5
640
4977
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.5
10.5
452
3292
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
10.5
1342
11761
RT272
NOMESCO Finland
NA
10.1
10.5
20
20
M06
ICD-10 Finland
Other rheumatoid arthritis
6.6
10.5
26
40
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
3.7
10.5
44
120
K07.60
ICD-10 Finland
Snapping jaw
2.1
10.5
124
620
G72.9
ICD-10 Finland
Myopathy, unspecified
6.2
10.4
27
44
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
10.4
223
1370
XQ844
NOMESCO Finland
Other microscope or electron microscope examination
+∞
10.4
10
*
R03AC03
ATC
terbutaline; inhalant
1.6
10.4
304
2030
Z01.2
ICD-10 Finland
Dental examination
1.4
10.4
848
6926
SXC03
NOMESCO Finland
Other oral or dental procedure
4.8
10.2
33
70
M01CB01
ATC
sodium aurothiomalate; parenteral
3.6
10.2
44
123
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
6.6
10.2
25
38
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
10.2
476
3522
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
10.2
143
767
R60.0
ICD-10 Finland
Localized oedema
1.7
10.2
217
1330
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
10.1
573
4399
WX892
NOMESCO Finland
Monitored bed care
1.9
10.0
136
719
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.1
10.0
53
173
R11
ICD-10 Finland
Nausea and vomiting
1.8
10.0
168
955
ZXA05
NOMESCO Finland
Left side
1.4
10.0
480
3566
WW200
NOMESCO Finland
Immunization
2.8
10.0
62
223
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.4
9.9
83
353
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.0
9.8
128
666
SPAT1301
SPAT
No procedures
1.4
9.8
625
4889
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.6
9.8
231
1458
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
2.5
9.8
73
294
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
9.7
1044
8867
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.2
9.7
98
460
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
9.7
521
3956
B02.9
ICD-10 Finland
Zoster without complication
2.0
9.7
118
598
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
5.8
9.7
26
45
J99.1*M35.0
ICD-10 Finland
Respiratory disorders in sicca syndrome [Sjögren]
55.2
9.6
11
*
M35.4
ICD-10 Finland
Diffuse (eosinophilic) fasciitis
55.2
9.6
11
*
XQ848
NOMESCO Finland
Dermatological photography
2.8
9.6
58
207
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
2.9
9.6
57
202
WX203
NOMESCO Finland
Infraclavicular plexus blockade
2.9
9.6
56
196
P01AB01
ATC
metronidazole; oral, rectal
1.3
9.5
852
7029
A12BA01
ATC
potassium chloride; oral
2.3
9.5
89
401
M03BX02
ATC
tizanidine; oral
1.3
9.5
1317
11590
S01GX01
ATC
cromoglicic acid; ophthalmic
1.4
9.5
438
3226
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
2.6
9.5
69
275
RT274
NOMESCO Finland
NA
15.1
9.5
15
10
C03DA01
ATC
spironolactone; oral
1.7
9.5
188
1130
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.0
9.5
111
556
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
9.5
121
625
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
4.2
9.5
34
81
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
9.5
325
2253
D02AE01
ATC
carbamide; topical
1.9
9.5
143
787
JN4BD
NOMESCO Finland
Extensive body CT
1.7
9.5
201
1234
B07.9
ICD-10 Finland
Verruca simplex
2.5
9.4
74
306
RT160
NOMESCO Finland
NA
100.4
9.4
10
*
SPAT1263
SPAT
Sampling
1.3
9.4
851
7032
XG460
NOMESCO Finland
Short time oxymetry
3.7
9.4
39
106
M34
ICD-10 Finland
Systemic sclerosis
30.1
9.4
12
*
J99.1*M33.2
ICD-10 Finland
Respiratory disorders in polymyositis
+∞
9.4
9
*
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
12.4
9.4
16
13
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
6.9
9.3
22
32
M31.3
ICD-10 Finland
Wegener granulomatosis
8.7
9.3
19
22
A02BA04
ATC
nizatidine; systemic
1.8
9.3
160
921
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
4.5
9.3
31
69
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
9.5
9.3
18
19
K59.1
ICD-10 Finland
Functional diarrhoea
2.1
9.3
107
533
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
2.4
9.2
73
305
N30.0
ICD-10 Finland
Acute cystitis
1.5
9.2
295
2011
K76.9
ICD-10 Finland
Liver disease, unspecified
3.4
9.2
43
129
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
9.2
331
2317
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
7.7
9.1
20
26
D07AC13
ATC
mometasone; topical
1.4
9.1
568
4417
E000003
ATC
NA
2.1
9.1
96
458
NDL52
NOMESCO Finland
Tenosynovectomy of hand
5.1
9.1
27
53
ND2AE
NOMESCO Finland
Hand and fingers ultrasound examination
10.1
9.0
17
17
WZA90
NOMESCO Finland
Other doctors statement
1.4
9.0
444
3313
ND1AA
NOMESCO Finland
Wrist X-ray examination
1.9
9.0
133
725
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.5
9.0
71
295
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.8
9.0
159
924
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.0
9.0
49
165
R01AD08
ATC
fluticasone; nasal
1.4
9.0
598
4702
J45.8
ICD-10 Finland
Mixed asthma
2.5
9.0
69
285
XA402
NOMESCO Finland
ENMG
2.5
8.9
66
267
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
8.9
449
3359
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
8.9
1069
9187
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
2.7
8.9
57
212
R20.2
ICD-10 Finland
Paraesthesia of skin
1.8
8.9
142
798
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
8.8
79
350
D02AX
ATC
Other emollients and protectives
2.4
8.8
73
310
ZX108
NOMESCO Finland
Inhalation
6.8
8.8
21
31
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
10.7
8.8
16
15
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.1
8.8
99
489
6BA02
NOMESCO Finland
NA
9.5
8.8
17
18
H16.0
ICD-10 Finland
Corneal ulcer
2.1
8.7
92
442
E000002
ATC
NA
1.6
8.7
228
1478
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
8.7
971
8246
N35.0
ICD-10 Finland
Post-traumatic urethral stricture
50.2
8.7
10
*
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.5
8.7
39
114
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
8.6
175
1061
A03FA02
ATC
cisapride; oral, rectal
1.8
8.6
156
913
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
8.6
575
4519
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
8.5
1111
9627
B01AC04
ATC
clopidogrel; oral
1.6
8.5
226
1473
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.0
8.5
99
495
C09CA06
ATC
candesartan; oral
1.4
8.5
410
3046
N06AX11
ATC
mirtazapine; oral
1.3
8.4
637
5100
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.7
8.4
161
957
S01KA02
ATC
hypromellose; ophthalmic
2.8
8.4
50
178
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.1
8.4
96
477
K02.1
ICD-10 Finland
Caries of dentine
1.3
8.4
1142
9953
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.8
8.4
141
805
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
3.5
8.4
37
107
XA800
NOMESCO Finland
Neuropsychological investigation
2.2
8.3
81
374
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
3.9
8.3
32
82
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.5
8.3
64
263
T78.4
ICD-10 Finland
Allergy, unspecified
2.0
8.3
102
521
L04AB01
ATC
etanercept; parenteral
3.1
8.3
43
140
M45
ICD-10 Finland
Ankylosing spondylitis
2.9
8.3
48
167
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
8.3
283
1956
ZXA10
NOMESCO Finland
Bilateral
1.5
8.3
351
2539
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.3
8.2
70
305
L84
ICD-10 Finland
Corns and callosities
2.4
8.2
69
297
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.1
8.2
88
427
J31.0
ICD-10 Finland
Chronic rhinitis
1.7
8.2
159
953
Z71.8
ICD-10 Finland
Other specified counselling
1.4
8.2
475
3643
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
4.7
8.1
26
56
R01AD09
ATC
mometasone; nasal
1.3
8.1
944
8039
TPX00
NOMESCO Finland
Biopsy of artery or vein
17.2
8.1
12
7
R52.9
ICD-10 Finland
Pain, unspecified
1.7
8.1
171
1047
N06AB04
ATC
citalopram; systemic
1.4
8.1
445
3382
ND1AE
NOMESCO Finland
Wrist ultrasound examination
6.8
8.1
19
28
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
2.3
8.1
71
313
R68.2
ICD-10 Finland
Dry mouth, unspecified
4.5
8.0
27
61
M25.1
ICD-10 Finland
Fistula of joint
22.1
8.0
11
5
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.0
8.0
95
478
TKC20
NOMESCO Finland
Catheterisation of bladder
1.9
8.0
112
602
M70.6
ICD-10 Finland
Trochanteric bursitis
1.5
8.0
260
1778
NG4AA
NOMESCO Finland
Lower leg X-ray examination
2.4
8.0
63
265
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
7.9
462
3541
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
4.8
7.9
25
53
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
2.9
7.9
46
161
UJD02
NOMESCO Finland
Gastroscopy
2.0
7.9
95
483
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.9
7.9
113
612
E000007
ATC
NA
1.9
7.9
119
658
M05BA01
ATC
etidronic acid; systemic
5.4
7.8
22
41
D01AE16
ATC
amorolfine; topical
1.6
7.8
223
1477
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
7.8
98
506
Z50.1
ICD-10 Finland
Other physical therapy
1.9
7.8
114
622
J01MA06
ATC
norfloxacin; oral
1.5
7.8
287
2018
S01
ICPC
Pain/tenderness of skin
2.1
7.7
80
382
SPAT1255
SPAT
Intravenous administration of medicine
1.8
7.7
123
692
4430A
ICD-9 Finland
Other peripheral vascular disease, Raynaud's syndrome
45.1
7.7
9
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
6.4
7.7
19
30
SPAT1325
SPAT
Vaccination
1.3
7.7
645
5235
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.6
7.7
53
206
I30.9
ICD-10 Finland
Acute pericarditis, unspecified
7.4
7.7
17
23
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
7.6
786
6567
S29
ICPC
Skin symptom/complaint other
1.5
7.6
303
2164
R03BA08
ATC
ciclesonide; inhalant
1.6
7.6
172
1076
L01
ICPC
Neck symptom/complaint
1.5
7.6
274
1917
NJ3DG
NOMESCO Finland
Very extensive MRI examination of extremities with high intensity magnet
18.4
7.6
11
6
K11.7
ICD-10 Finland
Disturbances of salivary secretion
18.4
7.6
11
6
7199L
ICD-9 Finland
Other and unspecified disorder of joint, Unspecified disorder of joint[MB ARTICULI NUD,USEAT NIVELET]
18.4
7.6
11
6
R63.4
ICD-10 Finland
Abnormal weight loss
2.3
7.6
65
282
KA1AE
NOMESCO Finland
Kidney ultrasound examination
2.9
7.6
44
154
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
11.9
7.6
13
11
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
11.9
7.6
13
11
L93.1
ICD-10 Finland
Subacute cutaneous lupus erythematosus
25.1
7.6
10
*
C08DB01
ATC
diltiazem; oral
2.0
7.6
90
456
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.6
7.5
214
1415
A41.9
ICD-10 Finland
Sepsis, unspecified
2.3
7.5
66
293
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
7.5
432
3302
3AC01
NOMESCO Finland
NA
4.1
7.5
27
66
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
1.9
7.5
102
545
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.5
7.5
225
1511
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
7.5
782
6546
C01DA14
ATC
isosorbide mononitrate; oral
1.6
7.4
216
1437
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
7.4
447
3441
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
80.3
7.4
8
*
S09
ICPC
Infected finger/toe
2.4
7.4
58
241
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
2.1
7.4
77
368
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.7
7.4
153
931
H19.3
ICD-10 Finland
Keratitis and keratoconjunctivitis in other diseases classified elsewhere
13.4
7.4
12
9
R76.8
ICD-10 Finland
Other specified abnormal immunological findings in serum
13.4
7.4
12
9
RT171
NOMESCO Finland
NA
13.4
7.4
12
9
R03BB04
ATC
tiotropium bromide; inhalant
1.7
7.4
161
996
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
7.3
169
1061
J01FA01
ATC
erythromycin; systemic
1.5
7.3
283
2009
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.2
7.3
74
349
N16.4*M35.0
ICD-10 Finland
Sjögren's syndrome with renal tubulo-interstitial disorders
+∞
7.3
7
*
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
7.3
7
*
R06AX22
ATC
ebastine; oral
1.4
7.3
354
2624
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.0
7.3
92
477
M12.3
ICD-10 Finland
Palindromic rheumatism
9.4
7.3
14
15
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
3.6
7.3
31
88
A07EA06
ATC
budesonide; oral, local oral
2.1
7.3
74
352
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.6
7.2
50
194
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.4
7.2
33
99
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.2
592
4783
XX1VW
NOMESCO Finland
Written report from radiologist
4.6
7.2
23
50
XCK00
NOMESCO Finland
Perimetry
1.8
7.2
126
733
M06.4
ICD-10 Finland
Inflammatory polyarthropathy
7.3
7.2
16
22
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
3.3
7.2
34
105
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
1.8
7.2
118
671
D69.0
ICD-10 Finland
Allergic purpura
4.8
7.1
22
46
SPAT1254
SPAT
Administration of medicine
1.5
7.1
264
1857
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
7.1
243
1680
M60.8
ICD-10 Finland
Other myositis
20.1
7.1
10
5
A06AD11
ATC
lactulose; oral
1.5
7.1
238
1637
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
7.1
1015
8828
A28
ICPC
Limited function/disability NOS
1.5
7.1
235
1612
M30.0
ICD-10 Finland
Polyarteritis nodosa
12.1
7.1
12
10
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.1
7.0
75
364
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
8.8
7.0
14
16
L01CB
ATC
Podophyllotoxin derivatives
8.8
7.0
14
16
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
3.0
7.0
38
129
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.1
7.0
79
392
N03AF02
ATC
oxcarbazepine; oral
2.3
7.0
62
277
TQW80
NOMESCO Finland
Local dermatologic skincare
2.4
6.9
55
231
NG1DA
NOMESCO Finland
X-ray of knees
2.8
6.9
41
147
G47.3
ICD-10 Finland
Sleep apnoea
1.4
6.9
349
2607
D07AA02
ATC
hydrocortisone; topical
1.5
6.9
257
1809
H57.1
ICD-10 Finland
Ocular pain
2.2
6.9
69
326
K75.4
ICD-10 Finland
Autoimmune hepatitis
7.5
6.9
15
20
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
7.5
6.9
15
20
I51.4
ICD-10 Finland
Myocarditis, unspecified
7.5
6.9
15
20
J47
ICD-10 Finland
Bronchiectasis
2.9
6.9
40
141
N05BA01
ATC
diazepam; systemic, rectal
1.5
6.9
251
1758
M79.9
ICD-10 Finland
Soft tissue disorder, unspecified
3.7
6.9
28
77
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
4.4
6.8
23
53
RT271
NOMESCO Finland
NA
8.3
6.8
14
17
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.8
242
1688
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
4.2
6.8
24
58
I73.8
ICD-10 Finland
Other specified peripheral vascular diseases
11.0
6.8
12
11
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
5.0
6.8
20
40
TEG00
NOMESCO Finland
Punction of mandibular joint
9.3
6.8
13
14
SPAT1153
SPAT
Removal of sutures
1.3
6.8
587
4772
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.1
6.8
68
322
N35.1
ICD-10 Finland
Postinfective urethral stricture, not elsewhere classified
40.2
6.8
8
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
6.8
508
4045
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
6.7
1151
10205
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.5
6.7
251
1769
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
2.4
6.7
52
218
M54.6
ICD-10 Finland
Pain in thoracic spine
1.7
6.7
135
819
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
2.9
6.7
37
128
L60.0
ICD-10 Finland
Ingrowing nail
2.0
6.7
79
401
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
22.6
6.7
9
*
M05.2
ICD-10 Finland
Rheumatoid vasculitis
22.6
6.7
9
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.2
6.7
60
271
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.8
6.6
108
611
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
2.6
6.6
45
176
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.6
200
1346
XG466
NOMESCO Finland
Sleep oxymetry
2.2
6.6
60
272
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
5.2
6.6
19
37
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
2.6
6.6
44
170
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
4.2
6.6
23
55
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
5.9
6.6
17
29
F45.0
ICD-10 Finland
Somatization disorder
5.5
6.6
18
33
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
1.9
6.6
89
475
C07AB02
ATC
metoprolol; systemic
1.4
6.6
356
2688
GD2SN
NOMESCO Finland
Lung ventilation SPECT
4.6
6.6
21
46
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
4.0
6.6
24
60
7102B
ICD-9 Finland
Diffuse diseases of connective tissue, Sicca syndrome[SYNDROMA SICCUM SECUNDARIUM]
12.3
6.6
11
9
L03
ICPC
Low back symptom/complaint
1.3
6.6
468
3694
N05CD07
ATC
temazepam; oral
1.5
6.6
219
1507
A01AB10
ATC
natamycin; local oral
2.2
6.6
62
287
M31.6
ICD-10 Finland
Other giant cell arteritis
8.7
6.5
13
15
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.5
6.5
203
1376
L12
ICPC
Hand/finger symptom/complaint
1.4
6.5
267
1915
A06AC51
ATC
ispaghula, combinations; systemic
1.8
6.5
100
559
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
2.4
6.5
53
228
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
6.5
116
680
N04BC05
ATC
pramipexole; oral
1.7
6.5
136
833
ZZA00
NOMESCO Finland
Split skin graft
2.4
6.5
52
220
DHA10
NOMESCO Finland
Biopsy of cavity of nose
4.5
6.5
21
47
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
5.7
6.4
17
30
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
6.4
244
1727
L95.8
ICD-10 Finland
Other vasculitis limited to skin
7.4
6.4
14
19
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
7.4
6.4
14
19
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.4
83
436
ACC51
NOMESCO Finland
Release of median nerve
1.6
6.4
139
863
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
3.5
6.4
27
77
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.2
6.4
60
276
L50.0
ICD-10 Finland
Allergic urticaria
2.3
6.4
57
255
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
1.8
6.3
111
645
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
3.3
6.3
29
88
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.7
6.3
133
814
ZX100
NOMESCO Finland
Oral
3.2
6.3
31
99
RJ420
NOMESCO Finland
NA
6.6
6.3
15
23
J01FA09
ATC
clarithromycin; systemic
1.3
6.3
635
5259
R03BA02
ATC
budesonide; inhalant
1.4
6.3
339
2556
R03BA01
ATC
beclometasone; inhalant
1.4
6.3
275
1998
R55
ICD-10 Finland
Syncope and collapse
1.6
6.3
178
1178
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
6.3
449
3546
N06AG02
ATC
moclobemide; oral
1.9
6.3
90
490
I32.8*M32.1
ICD-10 Finland
Pericarditis (in) systemic lupus erythematosus
+∞
6.3
6
*
J99.1*M33.9
ICD-10 Finland
Respiratory disorders in dermatopolymyositis
+∞
6.3
6
*
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
6.2
470
3740
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.4
6.2
49
208
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
6.2
324
2431
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
1.8
6.2
94
523
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.2
6.2
30
95
R35
ICD-10 Finland
Polyuria
1.8
6.2
101
575
WZC30
NOMESCO Finland
Teaching
1.5
6.2
229
1610
R04.2
ICD-10 Finland
Haemoptysis
2.3
6.2
51
221
SPAT1210
SPAT
Application of cast or individual aid
1.9
6.2
85
455
M01AB01
ATC
indometacin; systemic, rectal
1.7
6.2
115
684
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.0
6.2
75
386
EB1WA
NOMESCO Finland
NA
5.3
6.1
17
32
R03DC03
ATC
montelukast; oral
1.4
6.1
324
2438
N03AX09
ATC
lamotrigine; oral
1.9
6.1
89
488
WX204
NOMESCO Finland
Axillary plexus blockaced
2.2
6.1
59
276
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.4
6.1
291
2148
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.4
6.1
271
1973
B35.3
ICD-10 Finland
Tinea pedis
2.0
6.1
70
351
H53.1
ICD-10 Finland
Subjective visual disturbances
1.7
6.1
119
714
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
8.6
6.1
12
14
K59.0
ICD-10 Finland
Constipation
1.8
6.0
96
543
M54.8
ICD-10 Finland
Other dorsalgia
1.9
6.0
78
410
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
2.6
6.0
40
155
G50.1
ICD-10 Finland
Atypical facial pain
2.6
6.0
41
162
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
2.0
6.0
74
383

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
995
637
25.34
307.65
3.5
1.5
1.1
1.2
g/l
13.51
968
600
597
447
17.25
307.65
1.7
1.1
17.4
0.6
u/ml
—
31
5
333
226
16.85
307.65
3.2
1.3
36.3
26.8
iu/ml
0.61
60
11
290
154
21.18
307.65
1.4
1.1
—
—
—
0
0
787
567
19.83
307.65
1.9
1.2
27.1
3.7
u/ml
13.05
327
95
803
615
18.79
307.65
1.8
1.2
32.0
28.2
u/ml
0.14
113
36
681
438
21.02
307.65
1.8
1.2
4.2
3.9
u/ml
0.04
106
34
642
466
18.21
307.65
1.8
1.2
56.9
36.4
u/ml
1.35
152
40
786
844
13.14
307.65
1.8
1.2
3.8
1.3
u/ml
1.78
57
65
1353
2981
8.74
307.65
2.2
1.3
1191.1
547.5
titre
22.76
764
603
784
558
20.04
307.65
1.9
1.2
13.3
2.7
u/ml
3.15
203
62
995
613
26.36
307.65
3.5
1.5
0.2
0.2
g/l
21.17
965
577
484
263
22.60
307.65
1.8
1.2
61.6
52.6
u/ml
0.16
65
14
2016
10426
5.89
304.14
12.7
5.6
0.6
0.6
e9/l
0.94
1916
9017
2020
10472
5.90
303.56
12.7
5.7
0.0
0.0
e9/l
1.70
1918
9053
680
1532
5.73
297.39
3.7
2.7
11.7
10.4
g/l
8.30
648
1391
2039
10862
5.83
289.98
13.1
5.9
0.2
0.2
e9/l
6.60
1949
9544
2023
10746
5.69
287.67
12.8
5.7
1.7
1.9
e9/l
21.93
1938
9485
149
27
58.63
265.43
1.9
1.5
—
—
—
0
0
1514
6922
4.03
252.42
11.3
5.6
—
—
—
0
0
184
86
23.02
249.95
1.2
1.1
—
—
—
0
0
1822
9503
4.41
249.58
13.1
5.8
0.7
0.7
%
1.42
1779
8848
2099
12184
5.58
247.47
15.3
8.8
3.8
4.0
e9/l
5.14
1990
10651
1844
9790
4.40
243.94
13.1
5.8
2.7
2.8
%
1.00
1804
9102
1848
9849
4.39
242.54
13.5
6.0
9.1
8.4
%
24.42
1804
9212
1854
10003
4.33
236.53
12.8
5.6
58.0
56.9
%
3.69
1809
9351
256
255
11.07
230.58
1.8
1.2
—
—
—
0
0
1857
10136
4.27
230.28
13.3
5.8
27.3
28.5
%
5.67
1814
9437
1357
6042
3.74
229.08
3.5
2.1
136.9
199.2
u/l
2.34
1299
5693
423
802
6.15
218.95
1.6
1.5
22.7
10.5
u/ml
0.68
11
17
522
1208
5.20
216.65
2.0
1.8
1.5
1.4
g/l
0.06
494
1101
200
166
13.01
202.63
1.7
1.1
38.1
82.5
u/ml
0.95
22
11
179
124
15.48
201.39
2.1
1.4
6.1
6.1
u/l
0.01
159
105
958
3996
3.27
168.04
1.5
1.3
43.2
32.4
iu/ml
1.10
396
1266
2231
15736
4.99
152.86
11.1
4.0
14.8
12.0
mm/h
14.44
2183
14611
1579
9116
3.00
149.57
3.1
2.3
80.6
77.8
nmol/l
3.92
1499
8248
900
3840
3.10
148.68
1.4
1.3
8.7
11.4
u/ml
0.71
354
1512
2209
15980
4.37
133.72
13.2
7.4
74.1
77.3
u/l
2.88
2175
15037
212
325
7.04
133.57
1.5
1.2
4.6
4.7
u/ml
0.01
114
129
1077
5322
2.80
132.62
3.7
2.9
923.1
1204.3
ng/l
2.24
966
4499
203
315
6.93
126.35
2.2
1.6
0.8
0.7
g/l
0.30
162
234
983
4758
2.76
124.29
8.6
4.3
—
—
—
0
0
2052
14429
3.39
123.84
8.5
4.3
—
—
—
0
0
101
59
17.80
123.51
2.0
1.4
7.6
8.8
ug/l
1.43
101
59
1642
10297
2.74
122.06
6.1
3.7
0.0
0.0
estimate
0.50
338
1876
1622
10149
2.71
120.41
7.7
6.4
1.2
1.2
mmol/l
1.49
1424
8596
249
496
5.47
119.94
1.6
1.4
12.3
23.0
iu/ml
—
16
8
1653
10452
2.73
119.93
6.2
3.7
0.0
0.0
estimate
1.32
346
1875
166
221
7.98
118.42
2.5
2.3
—
—
—
0
0
92
49
19.46
117.42
1.2
1.1
—
—
—
0
0
92
49
19.46
117.42
1.2
1.1
—
—
—
0
0
92
49
19.46
117.42
1.2
1.1
—
—
—
0
0
1626
10352
2.64
113.63
8.1
5.0
0.0
0.0
estimate
0.38
347
1905
889
4260
2.69
112.50
1.8
1.4
2.5
2.3
g/l
2.35
648
2604
496
1751
3.29
109.48
5.9
3.9
0.7
0.9
%
0.99
157
456
185
309
6.39
106.98
1.7
1.4
—
—
—
0
0
1472
9170
2.48
103.97
6.7
5.6
1.2
1.2
mmol/l
1.46
1386
8308
447
1530
3.34
103.37
2.1
2.8
68.2
66.7
g/l
3.19
419
1393
399
1278
3.53
102.46
1.7
2.6
—
—
—
0
0
471
1674
3.24
102.30
6.0
4.0
0.0
0.1
%
5.79
147
421
264
633
4.55
101.69
2.8
2.3
162.6
727.2
ug/l
1.08
242
588
144
194
7.82
101.53
1.8
1.5
2.8
2.9
g/l
0.32
114
131
143
194
7.76
100.21
1.8
1.5
0.4
0.4
g/l
0.05
113
131
145
200
7.64
100.15
1.9
1.5
—
—
—
0
0
143
195
7.72
99.76
1.8
1.5
7.7
6.8
g/l
1.03
112
132
448
1581
3.24
98.19
6.2
4.0
0.0
0.5
%
0.97
128
357
1316
8014
2.36
94.65
5.3
3.4
—
5.8
—
0
5
1082
6054
2.39
94.65
4.3
3.8
7.4
7.4
ph
1.54
193
1130
124
154
8.42
93.54
2.2
1.8
3.0
3.8
mg/l
1.44
119
147
1206
7171
2.32
90.43
5.5
3.6
72.1
92.0
e6/l
0.63
889
4925
437
1600
3.10
89.41
5.7
3.7
0.3
0.6
%
2.12
112
331
917
4884
2.39
88.40
5.5
3.7
—
—
—
0
0
1425
9295
2.25
82.88
16.0
9.0
0.0
0.0
e9/l
0.59
1279
7574
83
75
11.41
79.03
1.2
1.3
0.2
0.3
g/l
—
8
8
798
4180
2.34
78.12
3.5
2.5
4.2
7.0
e6/l
8.96
725
3648
94
108
9.01
75.34
1.3
1.1
8.2
7.7
u/ml
0.03
11
12
1011
5978
2.16
72.37
4.5
3.1
72.8
70.2
e6/l
0.02
849
4527
210
554
4.05
70.74
1.7
2.1
10.4
11.7
mg/l
1.15
197
511
1331
8795
2.10
70.51
5.8
4.6
35.3
35.8
g/l
2.48
1266
8200
235
675
3.74
70.14
1.7
2.6
12.5
10.2
g/l
6.02
211
579
208
554
4.01
69.11
1.3
1.2
801.4
1050.5
titre
0.28
14
21
921
5399
2.12
66.00
10.5
6.4
—
—
—
0
0
203
549
3.94
65.98
1.3
1.2
110.7
95.4
titre
0.20
15
39
463
2040
2.56
65.11
2.1
2.1
365.2
371.1
nmol/l
0.18
439
1860
913
5388
2.10
63.80
4.1
2.9
—
—
—
0
0
93
129
7.45
63.73
1.3
1.1
1.1
1.0
ratio
1.86
39
55
924
5499
2.08
62.94
4.4
3.0
0.2
0.4
e6/l
5.71
761
4111
544
2629
2.37
62.24
2.7
2.4
20.6
22.9
%
3.73
474
2253
613
3127
2.27
61.73
2.8
2.3
12.0
13.3
umol/l
5.10
579
2885
205
586
3.72
61.45
1.7
2.4
37.1
38.0
g/l
1.09
187
509
874
5133
2.08
61.37
2.9
2.4
2849.1
5360.8
umol/l
1.42
789
4456
635
3343
2.21
58.84
3.2
2.6
0.9
1.2
e6/l
1.51
428
1860
565
2836
2.28
58.81
2.7
2.3
2.3
2.4
g/l
0.62
536
2626
1486
10684
1.97
57.12
6.9
6.1
9.6
10.8
umol/l
6.70
1428
10122
361
1498
2.65
56.91
3.3
2.9
124.3
184.1
ng/l
2.91
338
1354
485
2327
2.35
55.84
1.5
1.5
—
—
—
0
0
103
183
5.83
55.63
2.2
2.3
1.1
1.2
e9/l
0.52
68
107
865
5220
2.01
55.09
2.9
2.2
3.0
3.0
mg/l
0.17
768
4458
837
5000
2.01
54.80
5.4
4.2
—
—
—
0
0
354
1507
2.57
52.75
2.3
2.4
38.8
23.0
au/ml
0.79
17
91
331
1371
2.63
52.14
1.3
1.3
35.1
45.5
au/ml
—
10
63
87
143
6.27
50.84
1.3
1.1
213.5
131.4
titre
0.52
31
28
537
2791
2.18
50.46
2.5
1.9
—
—
—
0
0
151
407
3.88
49.12
4.2
3.6
59.2
57.6
%
0.83
151
407
883
5538
1.92
48.97
7.1
4.1
0.0
0.0
estimate
1.28
347
1880
84
140
6.17
48.41
2.1
2.0
11.6
12.5
%
0.21
38
54
369
1666
2.43
48.23
5.5
3.6
—
—
—
0
0
88
158
5.74
46.99
2.3
2.0
50.0
41.3
%
—
10
23
423
2051
2.28
46.84
3.7
2.6
1.7
1.8
%
1.46
394
1826
57
69
8.43
43.75
1.3
1.1
—
—
—
0
0
1752
13936
1.87
42.68
6.2
4.5
3732.8
2197.9
e6/l
0.37
33
186
233
894
2.77
42.36
1.3
1.2
—
—
—
0
0
1319
9703
1.76
41.17
3.6
2.8
116.8
103.5
ug/l
1.04
1243
9026
1064
7383
1.77
40.51
4.5
3.5
27.1
48.5
ng/l
1.21
733
4689
216
816
2.80
40.40
2.4
1.8
1.5
1.5
g/l
0.50
196
707
448
2368
2.09
39.36
2.1
1.7
—
—
—
0
0
71
123
5.91
39.34
2.0
2.5
414.8
565.9
e6/l
0.97
58
101
148
462
3.34
38.54
1.7
1.7
7573.6
10904.2
e6/l
0.75
114
337
778
4979
1.82
38.53
1.4
1.3
2.0
1.5
u/ml
0.40
206
1336
324
1520
2.30
38.33
1.3
1.4
—
—
—
0
0
2344
21011
2.95
38.11
27.0
13.2
17.6
21.8
mg/l
12.27
2084
16496
454
2445
2.05
37.78
1.9
1.4
—
—
—
0
0
718
4507
1.83
37.75
6.7
4.1
1.0
1.0
kg/l
1.79
94
650
28
13
21.77
37.48
1.3
1.2
31.2
24.4
u/ml
—
5
5
52
68
7.79
37.45
1.1
1.1
—
—
—
0
0
67
117
5.86
36.82
2.0
2.5
0.2
0.2
e9/l
0.80
58
100
1148
8291
1.71
36.77
2.1
2.0
97.7
96.8
pmol/l
0.26
614
4160
53
73
7.40
36.50
1.3
1.2
—
—
—
0
0
132
397
3.45
36.44
1.3
1.7
—
—
—
0
0
722
4638
1.78
34.63
1.6
1.5
20.2
21.2
nmol/l
1.01
637
3976
152
518
3.06
34.18
1.5
1.4
—
—
—
0
0
473
2678
1.95
33.80
2.2
2.2
148.9
118.1
ug/g
0.69
377
2120
542
3218
1.87
33.48
1.6
1.6
—
—
—
0
0
622
3858
1.82
33.36
4.0
2.7
509.7
530.4
mosm/kgh2o
1.70
549
3287
160
570
2.93
33.26
1.9
3.7
34.3
51.0
mg/l
0.81
132
471
1012
7210
1.68
33.01
3.4
3.3
2.3
2.4
mmol/l
4.03
891
6361
183
705
2.72
32.86
2.3
2.0
2.0
2.0
ug/l
0.02
156
621
309
1511
2.19
32.82
2.8
2.6
68.3
71.1
e9/l
0.67
227
1141
159
569
2.92
32.78
1.9
3.7
44.1
63.2
mg/l
0.76
132
469
1063
7683
1.67
32.73
11.0
8.2
1.2
1.2
inr
0.21
306
2255
45
59
7.75
32.33
1.1
1.0
—
—
—
0
0
504
2955
1.88
32.25
1.3
1.2
—
—
—
0
0
730
4789
1.74
32.10
2.0
1.8
1.1
1.1
mg/l
0.15
587
3642
154
553
2.90
31.55
1.9
3.7
1.3
1.6
ratio
0.38
13
45
66
132
5.11
31.33
2.2
2.6
532.2
756.3
e6/l
1.53
26
58
608
3807
1.79
31.32
1.7
1.8
—
—
—
0
0
104
296
3.62
31.22
2.9
3.4
1.2
1.3
%
0.16
88
239
915
6420
1.67
31.17
3.0
2.5
61.6
57.0
u/l
1.02
868
5930
579
3605
1.79
30.26
1.8
1.7
1194.8
1190.2
nmol/l
0.04
476
2729
513
3098
1.83
29.60
3.8
2.7
2.9
3.3
e6/l
0.32
307
1626
354
1892
2.02
29.57
2.9
2.2
0.2
0.2
g/l
0.04
326
1778
40
52
7.80
28.94
1.3
1.2
—
—
—
0
0
435
2514
1.88
28.80
5.7
5.4
1.0
1.0
mmol/l
0.00
407
2323
58
112
5.28
28.65
2.7
2.8
49.0
44.1
%
0.68
20
34
293
1481
2.11
28.42
3.4
2.9
3.7
4.0
e9/l
1.25
224
1189
809
5624
1.65
27.85
5.7
3.3
—
—
—
0
0
220
999
2.32
27.79
2.0
1.9
—
—
—
0
0
286
1450
2.10
27.49
1.4
1.3
186.7
181.1
u/ml
0.04
257
1331
1466
11789
1.59
27.19
5.9
4.5
6.4
6.6
mmol/l
4.14
1400
10976
508
3175
1.75
25.70
4.1
3.3
0.8
0.8
mmol/l
1.17
473
2957
111
376
3.04
25.22
1.4
1.3
—
—
—
0
0
105
351
3.08
24.41
1.5
1.6
—
—
—
0
0
83
242
3.51
24.06
2.8
2.6
—
—
—
0
0
110
385
2.94
23.60
1.3
1.3
—
20.3
—
0
10
898
6603
1.56
23.52
3.6
3.1
—
—
—
0
0
45
83
5.50
23.38
2.2
1.9
—
—
—
0
0
110
388
2.92
23.27
2.4
2.2
126.0
129.0
g/l
0.49
62
287
101
342
3.04
22.97
1.3
1.3
129.3
112.0
u/ml
0.36
20
61
199
966
2.15
21.28
3.7
2.7
0.2
0.3
e6/l
1.14
192
930
560
3758
1.63
21.22
4.7
3.5
274.0
300.7
ng/l
0.14
421
2718
100
356
2.88
20.82
1.2
1.2
306.6
268.2
u/ml
0.32
65
213
310
1772
1.86
20.82
1.2
1.2
—
—
—
0
0
112
424
2.72
20.78
1.9
3.8
—
—
—
0
0
284
1583
1.90
20.63
8.0
7.3
9.0
9.0
mmol/l
0.06
268
1509
189
915
2.15
20.34
1.1
1.1
1.7
1.0
u/ml
—
8
9
454
2924
1.68
20.09
2.6
2.1
30.3
29.4
s
1.70
444
2834
25
29
8.70
19.78
1.1
1.1
—
—
—
0
0
71
213
3.40
19.73
2.6
3.8
—
—
—
0
0
1936
17124
1.59
19.67
5.0
4.3
14.8
14.7
pmol/l
1.86
1826
15758
350
2121
1.76
19.29
8.2
7.5
1.1
1.1
mmol/l
0.02
279
1648
351
2130
1.75
19.25
8.2
7.4
5.0
5.1
kpa
1.03
330
2039
350
2130
1.75
18.99
8.2
7.4
12.2
12.7
kpa
1.05
331
2038
338
2041
1.76
18.83
4.4
4.1
—
—
—
0
0
63
181
3.55
18.72
2.3
3.1
60.4
55.8
%
0.72
42
125
376
2349
1.71
18.54
2.8
2.6
6.4
7.7
umol/l
1.00
326
2032
139
616
2.33
18.52
1.3
1.2
—
—
—
0
0
169
813
2.16
18.47
1.1
1.1
—
—
—
0
0
774
5740
1.51
18.45
4.5
3.7
—
—
—
0
0
22
24
9.24
18.21
1.3
1.1
—
—
—
0
0
377
2370
1.70
18.14
24.3
22.7
1.3
1.3
inr
0.03
66
334
268
1535
1.84
17.79
2.5
2.3
10.5
6.7
ug/l
0.60
224
1345
311
1865
1.76
17.70
8.9
8.0
95.5
96.0
%
0.76
297
1804
276
1610
1.80
17.24
3.2
3.5
83.8
81.6
ng/l
0.13
251
1392
1115
8966
1.44
17.21
2.3
2.1
—
—
—
0
0
158
763
2.14
17.10
2.5
2.1
21.9
21.2
s
0.43
137
665
208
1114
1.95
16.96
4.7
3.5
5.1
5.2
kpa
1.14
197
1042
56
160
3.56
16.80
1.1
1.1
—
—
—
0
0
59
175
3.43
16.73
1.6
1.5
37.4
36.6
%
0.05
36
106
548
3860
1.54
16.33
2.8
2.9
2.4
2.5
mmol/l
0.30
493
3404
203
1102
1.92
15.89
4.6
3.5
7.4
7.4
ph
0.70
30
137
19
21
9.11
15.55
1.4
1.2
—
—
—
0
0
69
236
2.98
15.50
3.0
2.6
—
—
—
0
0
275
1658
1.74
15.28
7.9
6.7
1.3
1.3
mmol/l
0.94
265
1597
692
5192
1.46
14.95
5.2
3.7
93.7
93.6
%
0.05
672
5049
95
391
2.49
14.94
1.1
1.2
—
—
—
0
0
81
309
2.68
14.87
1.4
1.6
—
—
—
0
0
275
1676
1.72
14.69
3.5
3.6
5.8
5.8
kpa
0.15
267
1631
2145
19790
1.60
14.57
6.1
5.1
1.9
2.0
mu/l
0.55
2035
18312
272
1658
1.72
14.51
3.6
3.6
2.3
2.0
mmol/l
0.80
231
1365
26
47
5.58
13.83
2.0
2.2
130.7
145.0
e6/l
0.11
14
22
57
187
3.10
13.79
1.2
1.2
—
—
—
0
0
81
322
2.57
13.72
1.2
1.2
—
—
—
0
0
65
234
2.83
13.36
1.7
1.6
48.9
57.8
%
0.90
38
146
251
1538
1.70
13.11
9.1
8.2
—
—
—
0
0
351
2342
1.58
13.06
9.0
6.6
104.6
104.4
mmol/l
0.31
341
2297
232
1396
1.73
12.94
3.5
2.9
—
—
—
0
0
86
363
2.42
12.85
1.7
1.6
—
—
—
0
0
2344
22264
1.89
12.79
20.9
10.2
24.7
24.8
u/l
0.05
2320
21521
126
626
2.07
12.70
1.1
1.1
4.5
4.5
u/ml
0.00
14
81
276
1751
1.65
12.62
9.6
8.3
118.8
120.4
g/l
0.72
264
1690
96
430
2.28
12.55
4.4
3.1
24.2
25.2
mmol/l
1.35
87
382
55
189
2.95
12.31
1.6
1.4
4669.7
90437.8
e6/l
1.24
40
132
76
310
2.50
12.24
1.4
1.5
—
—
—
0
0
203
1195
1.76
12.23
5.0
5.2
—
—
—
0
0
43
131
3.32
11.77
1.2
1.2
—
—
—
0
0
1630
14476
1.36
11.76
4.7
3.5
—
—
—
0
0
1927
17592
1.42
11.76
29.5
16.1
13.9
13.7
%
13.08
1912
17212
73
299
2.48
11.67
4.2
2.7
—
—
—
0
0
260
1662
1.63
11.52
4.2
3.6
1.2
1.2
mmol/l
0.73
240
1442
573
4329
1.42
11.45
1.7
1.6
14433442.6
33158041.3
pmol/l
0.58
485
3604
149
815
1.88
11.41
4.4
3.5
—
—
—
0
0
288
1892
1.59
11.39
1.5
1.4
—
—
—
0
0
170
972
1.80
11.30
10.7
9.4
23.9
24.4
mmol/l
1.05
158
916
106
517
2.10
11.25
2.2
2.1
—
—
—
0
0
232
1451
1.66
11.19
1.7
1.4
—
—
—
0
0
221
1384
1.65
10.61
3.2
2.9
4.7
4.6
kpa
0.15
214
1341
119
619
1.97
10.60
1.4
1.4
312.5
296.2
ug/g
0.39
66
340
261
1706
1.59
10.53
1.3
1.2
146.8
152.3
iu/ml
0.07
85
651
2259
21388
1.60
10.50
23.4
14.8
139.3
139.7
mmol/l
6.96
2223
20854
77
340
2.31
10.46
1.1
1.1
—
—
—
0
0
190
1152
1.70
10.31
7.2
7.2
25.2
24.5
mmol/l
1.40
177
1074
35
102
3.47
10.29
1.3
1.7
—
—
—
0
0
48
170
2.86
10.23
1.2
1.2
40.6
38.3
mg/l
0.16
41
139
52
193
2.73
10.17
1.3
2.0
—
—
—
0
0
46
160
2.91
10.13
1.1
1.1
252.3
250.0
mg/l
0.03
39
136
175
1044
1.73
10.07
4.3
3.2
—
—
—
0
0
25
58
4.34
10.05
2.1
2.6
143.5
100.9
au/ml
—
5
11
25
58
4.34
10.05
1.3
1.4
39.0
46.4
%
0.36
20
50
75
334
2.28
10.00
1.1
1.1
—
—
—
0
0
95
467
2.08
9.91
1.2
1.3
3.6
3.7
mmol/l
0.41
87
440
95
468
2.07
9.86
1.4
1.5
172.8
1242.1
e6/l
1.07
82
380
21
43
4.92
9.78
6.3
4.6
—
—
—
0
0
2260
21453
1.57
9.76
23.6
15.0
3.9
3.9
mmol/l
2.03
2220
20875
336
2363
1.49
9.68
1.4
1.3
—
—
—
0
0
27
69
3.94
9.58
1.1
1.3
—
—
—
0
0
94
467
2.05
9.54
1.4
1.4
7.5
22.5
e6/l
1.21
76
356
45
161
2.83
9.44
1.4
1.3
—
—
—
0
0
292
2012
1.51
9.28
1.8
1.4
—
—
—
0
0
50
195
2.60
8.91
1.4
1.4
32.9
33.1
g/l
0.03
43
169
148
878
1.73
8.71
3.5
3.9
24.6
24.2
mmol/l
0.84
141
792
40
141
2.87
8.65
1.2
1.1
0.4
5.9
nmol/l
—
9
27
111
606
1.87
8.61
3.1
3.2
—
—
—
0
0
44
164
2.71
8.58
1.3
1.3
95296.3
93700.7
e6/l
0.01
20
91
48
188
2.58
8.50
1.4
1.3
4341.4
2523.7
e6/l
0.49
30
131
1141
9888
1.28
8.46
4.7
3.9
—
—
—
0
0
13
19
6.87
8.44
1.5
1.4
4.2
6.1
mmol/l
—
7
12
617
7588
0.75
8.42
2.9
2.7
—
—
—
0
0
194
1257
1.59
8.13
1.3
1.2
—
—
—
0
0
174
1100
1.63
8.07
8.3
7.0
25.0
24.9
mmol/l
0.12
174
1094
24
67
3.61
7.57
1.6
1.5
—
—
—
0
0
76
384
2.01
7.44
2.2
3.1
29.4
35.5
umol/l
1.71
70
332
117
683
1.75
7.33
2.3
3.2
0.5
0.3
g/l
0.92
43
255
179
1167
1.58
7.32
11.3
8.8
93.9
94.1
%
0.28
179
1161
40
155
2.61
7.28
1.3
1.4
—
—
—
0
0
42
167
2.54
7.26
1.1
1.2
—
—
—
0
0
67
328
2.07
7.16
1.1
1.0
3.1
2.6
u/ml
0.17
19
150
154
975
1.62
7.12
13.2
10.6
—
—
—
0
0
10
13
7.72
7.12
1.2
1.0
—
—
—
0
0
1529
13902
1.26
6.99
4.0
3.0
55.6
44.4
u/l
2.80
1442
13014
26
81
3.23
6.97
1.0
1.1
300.3
177.8
iu/ml
0.38
26
81
614
5032
1.29
6.72
2.8
2.2
—
—
—
0
0
787
6658
1.27
6.66
2.8
2.3
—
—
—
0
0
38
152
2.52
6.52
1.4
1.4
—
—
—
0
0
50
228
2.22
6.42
2.0
1.3
—
—
—
0
0
50
228
2.22
6.42
2.0
1.3
—
—
—
0
0
50
228
2.22
6.42
2.0
1.3
—
—
—
0
0
50
228
2.22
6.42
2.0
1.3
—
—
—
0
0
72
379
1.93
6.33
5.1
3.8
—
—
—
0
0
271
1983
1.41
6.28
2.5
2.3
38.2
36.6
u/l
0.09
233
1691
41
177
2.34
6.00
1.1
1.1
—
—
—
0
0
28
100
2.82
5.99
1.6
2.0
—
—
—
0
0
39
165
2.39
5.97
1.4
1.5
—
—
—
0
0
39
165
2.39
5.97
1.1
1.5
13.0
11.8
umol/l
0.55
39
154
99
587
1.71
5.93
6.2
7.4
1.4
1.3
mmol/l
0.64
87
511
18
49
3.69
5.92
1.2
1.1
—
—
—
0
0
69
368
1.90
5.86
3.7
2.5
16.0
16.2
%
0.16
40
179
163
1097
1.52
5.82
2.4
2.4
—
—
—
0
0
214
1523
1.44
5.79
2.8
3.2
4.3
4.5
pmol/l
1.41
192
1345
114
707
1.64
5.78
5.0
3.7
24.9
25.0
mmol/l
0.15
103
655
241
1754
1.41
5.76
6.9
4.0
—
—
—
0
0
109
674
1.65
5.60
1.2
1.2
—
—
—
0
0
76
425
1.81
5.58
1.4
1.5
—
—
—
0
0
50
243
2.08
5.52
1.8
1.5
—
—
—
0
0
18
52
3.48
5.45
1.0
1.0
—
—
—
0
0
164
1126
1.49
5.35
3.5
3.0
123.0
127.6
g/l
2.02
159
1101
48
233
2.08
5.33
1.4
1.3
—
—
—
0
0
20
63
3.19
5.31
1.5
1.2
36.1
38.2
g/l
—
9
36
31
127
2.46
5.12
1.4
1.1
—
—
—
0
0
13
31
4.21
5.09
1.0
2.0
—
—
—
0
0
65
359
1.83
5.00
1.4
1.3
58.8
62.0
mmol/l
0.27
56
291
141
2040
0.67
4.98
1.3
1.3
—
—
—
0
0
129
856
1.53
4.96
3.7
3.0
25.7
25.4
mmol/l
0.30
124
834
60
332
1.83
4.62
1.1
1.2
—
—
—
0
0
41
202
2.05
4.43
1.1
1.1
—
—
—
0
0
18
60
3.01
4.39
1.4
2.2
8.5
9.9
mg/l
0.39
18
50
24
94
2.57
4.38
1.7
1.3
2.0
5.0
%
—
8
18
42
211
2.01
4.32
1.1
1.5
—
—
—
0
0
111
740
1.52
4.22
5.9
6.1
1.8
1.6
%
0.94
103
694
16
51
3.15
4.20
1.0
1.2
—
—
—
0
0
41
207
2.00
4.17
1.4
1.6
—
—
—
0
0
86
1323
0.64
4.12
1.5
1.4
—
—
—
0
0
41
208
1.99
4.12
1.2
1.2
—
—
—
0
0
43
223
1.94
4.06
2.4
2.4
—
—
—
0
0
19
69
2.77
4.02
2.3
2.7
—
—
—
0
0
88
565
1.58
3.97
4.1
3.6
3.8
3.8
mmol/l
0.15
83
535
18
64
2.83
3.95
2.1
1.2
—
—
—
0
0
86
551
1.58
3.92
1.2
1.2
—
—
—
0
0
109
739
1.50
3.86
4.6
4.2
—
—
—
0
0
126
880
1.45
3.85
2.8
2.5
1.2
1.2
%
0.16
126
873
109
740
1.49
3.84
6.0
6.1
1.0
0.9
%
0.61
101
693
42
221
1.92
3.82
3.0
3.1
—
—
—
0
0
18
66
2.74
3.75
1.4
1.8
—
—
—
0
0
646
5631
1.20
3.74
3.5
3.2
685.6
361.2
mg/l
0.65
415
3401
8
12
6.68
3.67
1.0
1.0
—
—
—
0
0
67
411
1.65
3.66
6.0
4.0
7.9
8.6
kpa
2.66
67
406
37
191
1.95
3.58
1.4
1.2
—
—
—
0
0
18
68
2.66
3.56
39.4
30.7
7.1
7.5
ug/l
0.27
18
59
2254
21923
1.29
3.53
21.0
12.5
—
—
—
0
0
9
17
5.31
3.51
1.1
1.8
—
—
—
0
0
29
139
2.10
3.43
1.1
1.1
—
—
—
0
0
66
411
1.62
3.43
5.9
4.0
2.6
2.6
mmol/l
0.04
49
281
66
412
1.62
3.40
5.9
4.0
5.1
5.1
kpa
0.06
66
407
20
82
2.45
3.38
1.4
1.1
—
—
—
0
0
122
870
1.42
3.37
1.7
1.6
—
—
—
0
0
21
89
2.37
3.32
2.5
2.2
52.5
51.5
umol/l
0.04
11
66
687
6082
1.18
3.28
3.5
3.1
6.8
7.1
mmol/l
1.27
585
5143
26
122
2.14
3.26
1.2
1.2
—
—
—
0
0
1975
18983
1.19
3.22
5.8
5.5
38.5
39.3
mmol/mol
4.34
1870
17625
8
15
5.35
3.19
1.1
1.0
—
—
—
0
0
90
613
1.49
3.17
1.6
1.9
105.0
4.6
iu/l
0.49
31
220
19
79
2.42
3.13
1.4
1.2
—
—
—
0
0
27
131
2.07
3.12
1.1
1.1
—
—
—
0
0
45
260
1.74
3.11
1.0
1.2
—
—
—
0
0
668
5932
1.17
3.04
4.5
3.9
11.5
9.0
mg/mmol
0.54
438
3617
64
413
1.56
2.92
7.4
8.8
10.3
11.2
mmol/l
1.47
57
371
21
95
2.22
2.89
2.2
3.2
7.5
7.4
ph
1.21
11
31
64
414
1.56
2.89
7.4
8.8
104.6
105.0
mmol/l
0.22
57
372
16
64
2.51
2.87
1.6
1.9
—
—
—
0
0
20
91
2.21
2.73
1.9
2.3
16.1
107.1
ug/l
0.52
20
80
7
14
5.01
2.73
1.1
1.1
—
—
—
0
0
41
241
1.71
2.71
2.6
2.1
18.0
1118.6
u/ml
0.50
41
229
11
37
2.98
2.69
2.2
1.4
—
—
—
0
0
63
414
1.54
2.68
3.5
2.7
—
—
—
0
0
27
140
1.94
2.65
1.2
1.2
—
—
—
0
0
18
80
2.26
2.60
2.9
2.4
—
—
—
0
0
2368
23290
1.34
2.57
37.8
19.7
259.4
259.1
e9/l
0.07
2339
22745
10
33
3.04
2.52
1.9
1.6
—
—
—
0
0
10
33
3.04
2.52
1.3
1.2
478.5
40.6
ug/l
—
5
17
22
108
2.05
2.51
4.7
3.2
—
—
—
0
0
9
26
3.47
2.48
1.0
1.0
—
—
—
0
0
73
504
1.46
2.48
5.5
3.7
7.4
7.4
ph
0.06
66
406
7
16
4.38
2.47
1.0
1.0
—
—
—
0
0
2368
23300
1.33
2.47
37.5
19.6
91.5
90.9
fl
7.45
2353
23000
2368
23302
1.33
2.45
37.5
19.6
30.2
30.2
pg
0.25
2352
23000
2368
23304
1.32
2.43
37.7
19.7
4.4
4.4
e12/l
12.94
2332
22698
20
96
2.09
2.43
1.4
1.2
—
—
—
0
0
2368
23307
1.32
2.40
37.8
19.7
6.5
6.7
e9/l
3.42
2331
22696
20
97
2.07
2.37
1.1
1.1
1400.4
1636.9
miu/ml
0.47
20
97
2368
23312
1.32
2.35
38.0
19.8
131.1
133.6
g/l
16.87
2353
23008
6
13
4.62
2.27
1.2
1.1
—
—
—
0
0
55
366
1.51
2.25
2.7
3.1
0.7
0.8
nmol/l
0.87
44
281
5
9
5.56
2.21
1.0
1.8
393.4
164.4
ug/g
—
5
9
12
48
2.51
2.18
1.2
1.1
—
—
—
0
0
6
14
4.29
2.15
1.0
1.1
—
—
—
0
0
16
74
2.17
2.14
1.1
1.0
—
—
—
0
0
11
43
2.57
2.09
1.5
1.1
20.2
25.5
%
0.22
11
37
8
25
3.21
2.09
1.0
1.0
—
—
—
0
0
2079
20255
1.16
2.03
4.6
4.4
5.7
5.8
mmol/l
8.67
1943
18584
58
400
1.46
2.03
2.5
2.9
—
—
—
0
0
17
83
2.06
2.01
1.4
1.3
—
—
—
0
0
13
57
2.29
1.97
1.2
1.1
—
—
—
0
0
19
98
1.95
1.95
5.3
3.2
—
—
—
0
0
9
33
2.73
1.93
1.1
1.2
75.2
84.3
ng/l
—
9
33
11
45
2.45
1.93
2.6
2.8
—
—
—
0
0
13
58
2.25
1.90
2.7
1.5
—
—
—
0
0
26
151
1.73
1.87
2.2
2.1
—
—
—
0
0
53
369
1.45
1.80
1.3
1.2
—
—
—
0
0
8
29
2.76
1.79
1.3
1.1
—
—
—
0
0
17
88
1.94
1.74
3.8
2.9
—
—
—
0
0
16
82
1.96
1.69
1.6
2.9
58.3
179.5
umol/l
—
9
49
6
19
3.16
1.66
1.0
2.0
—
—
—
0
0
68
504
1.36
1.64
1.3
1.3
11.7
12.9
u/l
0.28
60
408
43
294
1.47
1.63
1.3
1.2
56.7
28.5
u/l
0.34
37
250
156
1294
1.22
1.58
1.3
1.3
32.2
30.8
iu/l
0.18
136
1118
1848
17955
1.11
1.57
32.2
17.0
329.9
331.6
g/l
12.65
1840
17824
12
235
0.51
1.57
1.0
1.1
—
—
—
0
0
27
169
1.60
1.52
1.3
1.1
351.2
395.3
nmol/l
0.53
20
157
7
28
2.50
1.45
1.0
3.1
—
—
—
0
0
12
59
2.04
1.43
1.7
1.3
—
—
—
0
0
54
397
1.37
1.41
1.5
1.4
16.7
29.0
u/l
2.89
46
329
5
17
2.94
1.36
1.0
1.1
—
—
—
0
0
31
454
0.68
1.35
1.5
1.4
—
—
—
0
0
18
105
1.72
1.33
1.2
1.4
—
76.0
%
—
0
12
31
451
0.68
1.31
1.5
1.4
—
—
—
0
0
53
394
1.35
1.31
1.5
1.4
0.3
0.4
nmol/l
0.26
42
300
8
34
2.36
1.29
1.0
1.0
—
—
—
0
0
64
492
1.31
1.27
5.7
4.2
—
—
—
0
0
51
379
1.35
1.27
1.1
1.3
—
—
—
0
0
27
178
1.52
1.26
1.3
1.2
0.2
0.6
u/ml
0.66
17
67
1971
19287
1.10
1.25
25.7
14.3
38.8
39.4
%
2.23
1381
14224
78
618
1.27
1.24
2.1
2.4
—
—
—
0
0
31
213
1.46
1.20
1.5
1.2
—
—
—
0
0
18
285
0.63
1.16
1.3
1.2
—
—
—
0
0
40
291
1.38
1.15
1.6
1.4
48.9
40.9
mu/l
0.25
35
266
18
110
1.64
1.15
1.1
1.4
135.4
131.7
nmol/l
0.11
18
110
15
87
1.73
1.15
4.3
2.7
—
—
—
0
0
38
275
1.39
1.13
1.2
1.3
310.8
304.2
pmol/l
0.04
33
215
95
781
1.22
1.12
2.1
2.0
11.1
11.5
nmol/l
0.15
81
689
34
469
0.72
1.10
1.6
1.5
—
—
—
0
0
303
2738
1.12
1.09
1.3
1.3
—
—
—
0
0
20
129
1.55
1.05
1.3
1.5
19.5
24.2
umol/l
0.32
20
122
16
98
1.64
1.03
1.3
1.6
—
—
—
0
0
228
2033
1.13
1.03
1.5
1.6
—
—
—
0
0
11
60
1.84
1.02
1.5
1.2
82.8
44.7
pmol/l
—
6
20
117
1373
0.84
1.02
1.7
1.7
—
—
—
0
0
7
35
2.00
1.00
4.1
9.0
—
—
—
0
0
26
182
1.43
0.96
5.6
2.7
172.8
23.9
mg/l
0.81
21
130
2013
19792
1.09
0.94
4.1
3.8
1.2
1.3
mmol/l
1.55
1890
18241
15
93
1.62
0.93
4.1
2.5
—
—
—
0
0
10
55
1.82
0.92
1.1
1.9
—
—
—
0
0
6
28
2.15
0.91
1.2
3.3
—
—
—
0
0
29
210
1.39
0.90
1.3
1.6
—
—
—
0
0
35
263
1.34
0.88
1.6
1.5
—
—
—
0
0
14
87
1.61
0.87
3.9
2.2
8.6
9.9
mmol/l
—
8
71
2098
20681
1.09
0.87
4.5
4.3
4.6
4.8
mmol/l
13.92
1988
19267
8
43
1.86
0.87
1.6
2.2
20.1
18.8
umol/l
—
8
43
87
732
1.20
0.86
1.5
1.3
177.3
221.8
miu/ml
0.56
32
362
8
44
1.82
0.85
1.6
1.2
0.9
4.4
%
—
8
35
23
162
1.42
0.84
1.6
1.8
15.7
19.4
nmol/l
2.12
23
151
19
129
1.48
0.83
1.1
1.2
—
—
—
0
0
8
46
1.74
0.82
2.0
1.5
—
—
—
0
0
25
180
1.39
0.82
1.2
1.4
18.3
12.5
mmol/l
—
8
42
23
164
1.41
0.79
1.2
1.1
—
—
—
0
0
6
33
1.82
0.79
1.8
1.1
—
—
—
0
0
29
216
1.35
0.78
4.2
2.4
—
—
—
0
0
47
375
1.26
0.78
1.1
1.1
3.9
4.0
u/ml
0.01
26
177
15
98
1.53
0.78
1.1
1.6
—
—
—
0
0
6
34
1.77
0.76
1.3
1.1
—
—
—
0
0
2082
20549
1.08
0.74
4.5
4.2
1.5
1.5
mmol/l
0.17
1963
19043
31
236
1.32
0.74
2.8
4.4
19.6
92.8
u/ml
1.58
11
69
222
2430
0.91
0.73
1.8
1.7
—
—
—
0
0
12
76
1.58
0.71
12.4
10.4
—
—
—
0
0
53
437
1.22
0.68
2.1
2.5
184.5
103.9
ug/min
0.21
31
268
10
61
1.64
0.68
2.4
1.9
—
—
—
0
0
103
901
1.15
0.68
2.1
2.0
4126.7
4553.7
u/l
0.04
33
367
7
120
0.58
0.67
16.6
12.1
699.6
871.1
nmol/l
—
7
115
18
129
1.40
0.63
3.7
3.3
—
—
—
0
0
11
72
1.53
0.59
1.8
1.1
—
12.0
%
—
0
7
8
53
1.51
0.58
1.1
1.7
—
—
—
0
0
81
709
1.15
0.56
2.9
3.5
22.3
2232.5
u/ml
0.93
66
610
6
39
1.54
0.53
1.2
1.2
—
—
—
0
0
6
39
1.54
0.53
1.7
1.9
—
—
—
0
0
18
135
1.34
0.51
1.0
1.0
—
—
—
0
0
20
153
1.31
0.50
1.7
2.2
10.9
10.8
%
0.06
20
153
97
868
1.12
0.50
1.1
1.1
—
—
—
0
0
314
2966
1.07
0.49
4.2
4.8
1.7
2.6
ug/l
3.55
273
2624
63
722
0.87
0.49
1.2
1.9
—
—
—
0
0
48
561
0.85
0.48
1.3
1.9
—
—
—
0
0
43
363
1.19
0.48
1.1
1.1
0.2
1.3
u/ml
2.02
18
147
27
333
0.81
0.48
1.2
2.5
—
—
—
0
0
63
719
0.87
0.47
1.2
1.9
—
—
—
0
0
7
50
1.40
0.45
1.3
1.1
—
—
—
0
0
159
1717
0.92
0.45
2.7
3.0
0.7
0.8
ug/l
0.32
107
1120
64
725
0.88
0.44
1.2
1.9
—
—
—
0
0
7
51
1.37
0.44
1.0
1.1
—
—
—
0
0
14
104
1.35
0.43
1.6
2.4
—
39.3
—
0
7
49
424
1.16
0.43
1.1
1.1
2.5
1.4
u/ml
0.28
20
164
63
712
0.88
0.42
1.3
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
15.4
—
0
10
59
664
0.89
0.38
1.2
1.9
—
—
—
0
0
11
146
0.75
0.36
1.1
1.1
—
—
—
0
0
6
43
1.40
0.35
4.5
3.4
—
—
—
0
0
86
788
1.09
0.33
1.8
1.6
293.2
309.6
mu/l
0.23
76
706
6
46
1.31
0.33
1.0
1.0
—
—
—
0
0
20
164
1.22
0.32
1.9
2.3
1.2
2.4
u/field
0.90
11
71
34
294
1.16
0.32
1.4
1.2
—
—
—
0
0
218
2074
1.06
0.31
3.0
4.1
3.1
21.5
ug/l
3.44
171
1660
35
305
1.15
0.30
2.1
1.7
49.6
42.7
nmol/l
0.47
35
291
59
652
0.90
0.30
1.2
1.3
—
—
—
0
0
39
344
1.14
0.29
1.1
1.1
—
—
—
0
0
46
513
0.89
0.28
1.3
1.3
—
—
—
0
0
226
2164
1.05
0.27
1.5
1.4
—
—
—
0
0
24
279
0.86
0.27
1.2
1.4
3.1
4.0
ug/l
0.32
18
245
32
281
1.14
0.26
1.6
1.2
—
—
nmol/l
—
0
0
156
1483
1.06
0.25
1.3
1.2
—
—
—
0
0
31
273
1.14
0.25
2.6
2.0
5.5
6.1
umol/l
0.18
21
190
2114
21027
1.04
0.24
4.9
4.7
2.7
2.8
mmol/l
13.93
1998
19471
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
44
484
0.91
0.23
1.5
2.9
—
—
—
0
0
5
40
1.25
0.22
1.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
1.0
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.0
1.0
—
—
—
0
0
6
51
1.18
0.19
1.0
1.3
51.5
63.1
mu/l
—
6
42
65
695
0.93
0.19
18.6
9.1
—
—
—
0
0
7
58
1.21
0.18
1.4
2.1
—
—
—
0
0
7
60
1.17
0.17
1.0
1.3
—
—
—
0
0
571
5613
1.02
0.17
1.6
1.7
1.4
1.4
mmol/l
0.03
503
4748
24
215
1.12
0.16
3.0
2.7
—
—
—
0
0
48
447
1.08
0.16
4.0
3.7
27.8
24.4
mg/l
0.29
35
286
37
341
1.09
0.15
1.1
1.1
—
—
—
0
0
44
410
1.07
0.15
2.0
2.2
0.8
0.8
nmol/l
0.09
34
340
12
103
1.17
0.13
1.7
1.3
—
—
—
0
0
576
5815
0.99
0.08
1.5
1.5
—
—
—
0
0
5
65
0.77
0.08
1.4
1.6
—
—
—
0
0
51
531
0.96
0.08
1.2
1.1
—
—
—
0
0
36
342
1.05
0.08
1.1
1.1
0.3
2.0
u/ml
3.04
11
77
26
246
1.06
0.06
1.1
1.1
0.1
0.4
u/ml
—
8
56
37
386
0.96
0.06
2.4
1.8
—
—
—
0
0
19
180
1.06
0.04
1.8
1.6
—
—
—
0
0
17
179
0.95
0.03
1.1
1.2
—
—
—
0
0
28
271
1.03
0.02
1.1
1.1
3.0
4.8
u/ml
0.50
14
101
12
113
1.06
0.01
1.9
1.5
1.5
1.2
nmol/l
0.42
12
91
17
163
1.04
0.01
1.9
1.5
0.9
1.0
g/l
0.56
17
163
16
161
0.99
0.00
1.6
1.6
6.5
6.5
mmol/l
—
9
107
29
295
0.98
0.00
1.1
1.1
6.0
3.1
u/ml
0.22
13
103
30
295
1.02
0.00
3.6
5.3
379.3
365.0
umol/l
0.22
23
254
15
146
1.03
0.00
4.0
6.3
—
—
—
0
0
14
138
1.01
0.00
1.6
1.3
—
1.5
—
0
8
34
338
1.01
0.00
1.1
1.1
44.8
1734.9
iu/ml
—
6
76
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
108.8
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
171.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_MCTD and mortality.

Females

Parameter HR [95% CI] p-value
M13_MCTD 1.667 [1.52, 1.83] < 0.001
Birth year 0.996 [0.99, 1.0] 0.294

During the follow-up period (1.1.1998 — 31.12.2019), 1763 out of 9083 females with M13_MCTD died.

Males

Parameter HR [95% CI] p-value
M13_MCTD 1.845 [1.6, 2.12] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2361 males with M13_MCTD died.

Mortality risk

Mortality risk for people of age

years, who have M13_MCTD.

N-year risk Females Males
1 0.185% 0.328%
5 0.883% 2.007%
10 2.493% 5.008%
15 4.925% 9.315%
20 8.356% 15.147%

Relationships between endpoints

Index endpoint: M13_MCTD – Mixed connective tissue disease

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data