Abruptio Placentae: Vaginal bleeding preceding the 20th week of gestation.
Premature separation of placenta [abruptio placentae]
DOID EFO Endpoint Browser PheWeb
O15_PLAC_PREMAT_SEPAR
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
913 |
4. Check minimum number of eventsNone |
913 |
5. Include endpointsNone |
913 |
6. Filter based on genotype QC (FinnGen only) |
913 |
Control definitions (FinnGen only)
- Control exclude
- O15_MATERN_CARE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O30-O48
- Name in latin
- Ablatio placentae praematura
Similar endpoints
↥List of similar endpoints to
Premature separation of placenta [abruptio placentae]
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6580 | 6580 | - |
| Only index persons | 6472 | 6472 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | - |
| Only index persons | 0.24 | 0.24 | - |
| Median age at first event (years) | |||
| Whole population | - | 30.95 | - |
| Only index persons | - | 30.93 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 913 | 913 | - |
| Unadjusted period prevalence (%) | 0.31 | 0.31 | - |
| Median age at first event (years) | 31.13 | 31.13 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 812
- Matched controls
- 8120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
38.4
323.0
464
272
O45.9
ICD-10 Finland
Premature separation of placenta, unspecified
+∞
323.0
337
*
6412B
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Premature separation of placenta[ABLATIO PLACENTAE ANTETEMPUS,SYNN PÄÄTT HOITOJAKSO]
+∞
268.0
242
*
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
+∞
260.9
236
*
O45.8
ICD-10 Finland
Other premature separation of placenta
+∞
177.8
164
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
21.4
146.9
225
143
8811
FHL
Cesarean section
11.2
125.9
262
332
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
65.4
122.6
141
26
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
20.8
108.1
165
98
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
1046.8
97.1
93
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
8.2
91.1
225
361
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
10.4
79.8
166
195
ZXD00
NOMESCO Finland
Emergency procedure
19.6
78.1
121
72
O60
ICD-10 Finland
Preterm labour and delivery
24.2
75.1
108
51
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
+∞
73.0
69
*
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
8.4
72.1
172
253
Z39.2
ICD-10 Finland
Routine postpartum follow-up
5.0
64.4
243
641
ZXD05
NOMESCO Finland
Urgent procedure
3.8
63.7
365
1429
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
4.7
61.2
246
689
O32.1
ICD-10 Finland
Maternal care for breech presentation
215.6
58.9
60
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
3.6
58.6
374
1571
6412A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Premature separation of placenta[ABLATIO PLACENTAE ANTETEMPUS,HOITOJAKSO ENNEN SYNN]
+∞
53.7
51
*
O82.0
ICD-10 Finland
Delivery by elective caesarean section
14.7
52.5
90
68
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
22.8
51.6
75
36
O45.0
ICD-10 Finland
Premature separation of placenta with coagulation defect
+∞
47.3
45
*
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
+∞
47.3
45
*
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
169.8
46.3
48
*
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
62.8
45.9
53
9
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
3.6
44.9
248
889
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
232.2
43.3
44
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.2
39.5
166
464
6440B
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]
12.3
36.9
68
60
O30.0
ICD-10 Finland
Twin pregnancy
362.1
35.2
35
*
SPAT1379
SPAT
Health check-up of pregnant person
3.9
34.3
156
464
O48
ICD-10 Finland
Prolonged pregnancy
+∞
33.6
32
*
W78
ICPC
Pregnancy
3.2
32.9
201
753
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
4.5
31.7
120
299
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
+∞
31.5
30
*
SPAT1197
SPAT
Extensive health check-up of expecting family
3.4
31.2
170
583
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
6.6
29.4
78
128
XMA22
NOMESCO Finland
General examination of pregnant woman
4.7
29.1
106
253
W92
ICPC
Compl labour/ delivery livebirth
14.5
28.4
48
35
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
28.3
27
*
SPAT1380
SPAT
Postpartum check-up
3.9
27.7
125
365
SPAT1196
SPAT
Monitoring of normal pregnancy
4.1
25.4
107
293
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
25.1
24
*
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
3.0
24.9
161
616
W84
ICPC
Pregnancy high risk
7.4
24.7
60
87
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
4.5
23.5
87
211
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
6.2
22.5
62
107
WX306
NOMESCO Finland
Lumbar epidural anesthesy
3.8
22.4
100
288
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.6
22.4
188
841
O44.0
ICD-10 Finland
Placenta praevia specified as without haemorrhage
+∞
22.0
21
*
O99.80
ICD-10 Finland
The fear of childbirth
4.6
21.5
77
180
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
3.2
21.2
119
410
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
+∞
20.9
20
*
O41.1
ICD-10 Finland
Infection of amniotic sac and membranes
+∞
20.9
20
*
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
20.9
20
*
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
+∞
20.9
20
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
4.1
20.4
82
215
O41.0
ICD-10 Finland
Oligohydramnios
+∞
19.9
19
*
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
2.7
19.8
149
622
O02.1
ICD-10 Finland
Missed abortion
3.7
19.5
88
255
MAA00
NOMESCO Finland
Amniocentesis
8.6
18.9
41
50
O46.8
ICD-10 Finland
Other antepartum haemorrhage
+∞
18.8
18
*
O40
ICD-10 Finland
Polyhydramnios
+∞
18.8
18
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.2
18.1
101
345
6441A
ICD-9 Finland
Early or threatened labour, Other threatened labour
+∞
17.8
17
*
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
183.8
17.6
18
*
WX320
NOMESCO Finland
Spinalanesthesy
2.4
17.3
167
793
O80.8
ICD-10 Finland
Other single spontaneous delivery
5.1
17.1
55
115
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.8
16.8
119
474
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
+∞
16.7
16
*
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
+∞
16.7
16
*
6563B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, SYNNYTYKSEN AIKANA]
4.8
16.5
56
124
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
2.9
16.5
110
422
G02CB01
ATC
bromocriptine; systemic
5.4
16.5
50
98
C07AG01
ATC
labetalol; systemic
7.1
16.4
40
59
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
7.0
16.2
40
60
Z39.0
ICD-10 Finland
Care and examination immediately after delivery
12.7
14.9
26
21
O32.2
ICD-10 Finland
Maternal care for transverse and oblique lie
152.6
14.5
15
*
SPAT1357
SPAT
Monitoring of problem during pregnancy
5.7
14.4
41
75
ZXE00
NOMESCO Finland
One hour or less
1.8
14.3
331
2219
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
4.9
14.0
46
99
O47.9
ICD-10 Finland
False labour, unspecified
15.0
13.6
22
15
6440A
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]
4.8
13.6
45
98
WX307
NOMESCO Finland
Obstetric epidural analgesia
2.7
13.5
94
371
O20.0
ICD-10 Finland
Threatened abortion
4.3
12.8
47
114
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
6.6
12.7
32
50
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
3.9
12.7
52
140
6581A
ICD-9 Finland
Other problems associated with amniotic cavity and membranes, Premature rupture of membranes
+∞
12.5
12
*
6418A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Other antepartum haemorrhage[ALIA HAEMORRHAGIA IN GRAVIDITATE,HOITOJ ENNEN SYNN]
+∞
12.5
12
*
Z34
ICD-10 Finland
Supervision of normal pregnancy
3.4
12.5
62
195
Z37.0
ICD-10 Finland
Single live birth
2.2
12.0
131
651
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
10.7
11.3
21
20
LGA10
NOMESCO Finland
Sterilisation by destruction or division of Fallopian tubes
9.8
11.3
22
23
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
3.0
10.9
62
215
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
4.7
10.8
36
80
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
10.4
10
*
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
4.3
10.2
37
90
MAC96
NOMESCO Finland
Other induction or advancement of labour
4.6
10.2
34
76
Z3232
NOMESCO Finland
Midwife
2.2
10.1
114
573
O14.1
ICD-10 Finland
Severe pre-eclampsia
8.0
9.7
21
27
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
9.2
9.6
19
21
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
+∞
9.4
9
*
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
+∞
9.4
9
*
O42.2
ICD-10 Finland
Premature rupture of membranes, labour delayed by therapy
+∞
9.4
9
*
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
+∞
9.4
9
*
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
+∞
9.4
9
*
W29
ICPC
Pregnancy symptom/complaint other
4.6
9.4
31
69
6542B
ICD-9 Finland
Abnormality of organs and soft tissues of pelvis, Previous Caesarean delivery[CICATRIX UTERI POSTOPERATIVA, SYNNYTYKSEN AIKANA]
6.0
9.1
24
41
O03.1
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage
4.7
9.0
29
63
O68.8
ICD-10 Finland
Labour and delivery complicated by other evidence of fetal stress
6.4
8.8
22
35
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
10.9
8.8
16
15
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
5.7
8.8
24
43
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
8.5
258
1808
NE1AG
NOMESCO Finland
MRI pelvimetry with high intensity magnet
+∞
8.3
8
*
6411A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Haemorrhage from placenta praevia[PLACENTA PRAEVIA CUM HAEMORRHAGIA,HOITOJ ENNEN SYNN]
+∞
8.3
8
*
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
4.6
8.2
27
60
SPAT1189
SPAT
Other ultrasound examination during pregnancy
3.7
8.1
34
95
MA3AE
NOMESCO Finland
Combined first trimester screening
2.9
8.1
47
167
6425A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, ENNEN SYNNYTYSTÄ]
10.2
8.0
15
15
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
3.2
8.0
40
129
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.2
7.8
28
68
6565A
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Poor foetal growth[SIKIÖN HIDASTUNUT INTRAUTERIININ KASVU,RASK AIK]
8.6
7.8
16
19
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
6.5
7.7
19
30
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
4.7
7.7
25
55
W85
ICPC
Gestational diabetes
3.1
7.6
39
129
B01AB05
ATC
enoxaparin; parenteral
1.7
7.5
185
1217
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
2.8
7.5
47
174
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
5.1
7.5
22
44
O68.3
ICD-10 Finland
Labour and delivery complicated by biochemical evidence of fetal stress
7.7
7.4
16
21
MAA40
NOMESCO Finland
Puncture of fetus
13.5
7.4
12
9
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
7.4
334
2560
MBA96
NOMESCO Finland
Other removal of retained products of conception after delivery or abortion
3.7
7.3
30
83
6400A
ICD-9 Finland
Haemorrhage in early pregnancy, Threatened abortion
5.0
7.3
22
45
8502
FHL
Evacuation and abrasion
2.3
7.3
63
283
Z30.2
ICD-10 Finland
Sterilization
1.8
7.1
134
815
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
1.8
6.9
133
811
WX600
NOMESCO Finland
Single shot through catheter
4.1
6.9
25
62
G03GA06
ATC
follitropin beta; parenteral
2.8
6.9
41
150
SPAT1383
SPAT
Extensive health check-up at 4 years of age
8.4
6.8
14
17
TMW99
NOMESCO Finland
Other minor surgical procedure in obstetrics
9.4
6.8
13
14
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
6.8
224
1588
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
40.4
6.8
8
*
LGA20
NOMESCO Finland
Sterilisation by constriction of Fallopian tubes
5.6
6.6
18
33
O85
ICD-10 Finland
Puerperal sepsis
6.0
6.6
17
29
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
10.1
6.5
12
12
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
5.4
6.5
18
34
H01
ICPC
Ear pain/earache
1.9
6.4
93
516
MAB20
NOMESCO Finland
Failed external version
+∞
6.3
6
*
6419A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Unspecified antepartum haemorrhage[HAEMORRHAGIA NUD IN GRAVIDITATE,HOITOJ ENN SYNN NUD]
+∞
6.3
6
*
6410A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Placenta praevia without haemorrhage[PLACENTA PRAEVIA SINE HAEMORRH,HOITOJ ENNEN SYNN]
+∞
6.3
6
*
6582B
ICD-9 Finland
Other problems associated with amniotic cavity and membranes, Delayed delivery after spontaneous or unspecified rupture of membranes
+∞
6.3
6
*
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
+∞
6.3
6
*
O34.0
ICD-10 Finland
Maternal care for congenital malformation of uterus
+∞
6.3
6
*
MAB10
NOMESCO Finland
External version
26.9
6.2
8
*
Z39.1
ICD-10 Finland
Care and examination of lactating mother
3.3
6.1
28
86
FM1QE
NOMESCO Finland
Extensive ultrasound of fetal heart
12.6
6.1
10
8
Mortality – FinRegistry
↥Association
Association between endpoint O15_PLAC_PREMAT_SEPAR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_PLAC_PREMAT_SEPAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_PLAC_PREMAT_SEPAR – Premature separation of placenta [abruptio placentae]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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