≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

COPD related to chronic (opportunist) infections

EFO MESH Endpoint Browser PheWeb

COPD_OPPORTUNIST_INFECTIONS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • J10_COPDNAS
23682

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

835

6. Filter based on genotype QC (FinnGen only)

835

Control definitions (FinnGen only)

Control conditions
not J10_COPDNAS

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5779 2148 3513
Only index persons 4088 1704 2384
Unadjusted period prevalence (%)
Whole population 0.09 0.06 0.10
Only index persons 0.08 0.06 0.09
Median age at first event (years)
Whole population 66.31 65.05 67.09
Only index persons 66.29 65.07 67.17

-FinnGen-

Key figures

All Female Male
Number of individuals 835 297 538
Unadjusted period prevalence (%) 0.19 0.10 0.24
Median age at first event (years) 66.79 62.21 69.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
724
Matched controls
7238
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R03BB04
ATC
tiotropium bromide; inhalant
63.7
323.0
496
239
J47
ICD-10 Finland
Bronchiectasis
824.0
323.0
589
38
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
634.7
323.0
613
61
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
926.8
323.0
347
7
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
24.8
300.5
511
638
R03AK06
ATC
salmeterol and fluticasone; inhalant
26.4
283.7
439
398
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
224.9
244.4
241
16
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
691.9
215.0
202
*
H02AB06
ATC
prednisolone; systemic
13.9
187.7
626
2275
R03AC02
ATC
salbutamol; inhalant
13.0
185.0
614
2177
J45.9
ICD-10 Finland
Asthma, unspecified
12.7
182.9
392
617
R03DA04
ATC
theophylline; systemic, rectal
24.7
182.1
269
169
J18.9
ICD-10 Finland
Pneumonia, unspecified
10.7
181.4
528
1453
UGC12
NOMESCO Finland
Flexible bronchoscopy
15.9
165.3
295
300
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
22.4
152.0
230
147
J01MA14
ATC
moxifloxacin; systemic
13.0
142.0
278
331
R03AC12
ATC
salmeterol; inhalant
22.9
132.1
197
116
R03BA05
ATC
fluticasone; inhalant
9.1
125.5
312
558
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
9.7
117.8
272
422
R03BB01
ATC
ipratropium bromide; inhalant
19.7
116.6
183
122
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
431.3
113.8
111
*
J45.1
ICD-10 Finland
Nonallergic asthma
13.0
112.0
213
225
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
9.2
110.4
262
419
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
15.5
107.3
186
158
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
84.2
102.9
114
16
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
5.6
101.0
508
2130
J96.1
ICD-10 Finland
Chronic respiratory failure
46.1
98.0
120
31
R03DC03
ATC
montelukast; oral
7.9
95.3
248
445
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
6.3
90.8
294
708
R03BA02
ATC
budesonide; inhalant
6.8
88.7
264
566
J01MA12
ATC
levofloxacin; systemic
5.4
82.9
320
931
R03BA01
ATC
beclometasone; inhalant
6.8
82.7
242
500
R95
ICPC
Chron obstructive pulmonary disease
33.9
80.1
105
36
H02AB07
ATC
prednisone; oral
6.3
79.4
249
559
J01FA06
ATC
roxithromycin; oral
4.4
77.0
434
1825
J01AA02
ATC
doxycycline; systemic
7.3
76.1
663
4332
J45.0
ICD-10 Finland
Predominantly allergic asthma
9.8
72.9
158
201
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
18.3
72.4
115
74
R03AK07
ATC
formoterol and budesonide; inhalant
5.9
71.5
234
544
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.8
68.2
147
184
J46
ICD-10 Finland
Status asthmaticus
18.0
67.1
107
69
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
47.8
66.8
81
19
51899
ICD-8 Finland
Bronchiectasis
245.6
66.4
67
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
65.1
66.1
76
13
R04.2
ICD-10 Finland
Haemoptysis
12.8
64.0
118
108
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.8
63.1
478
2433
R03AC03
ATC
terbutaline; inhalant
5.9
60.9
193
421
R03AC13
ATC
formoterol; inhalant
10.3
60.5
125
143
R06.0
ICD-10 Finland
Dyspnoea
4.1
59.9
312
1137
J45.8
ICD-10 Finland
Mixed asthma
14.7
58.0
100
78
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
8.6
56.4
130
179
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
580.0
55.3
54
*
XG410
NOMESCO Finland
Flow-volume spirometry
9.8
54.7
116
138
H02AB04
ATC
methylprednisolone; systemic
4.8
54.5
212
575
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
+∞
51.7
49
*
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
50.2
50.0
60
13
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
11.8
49.0
93
89
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
39.0
48.4
61
17
R02
ICPC
Shortness of breath/dyspnoea
4.7
46.4
179
472
J01FA09
ATC
clarithromycin; systemic
3.5
46.2
286
1146
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
17.2
45.0
72
46
R03AK08
ATC
formoterol and beclometasone; inhalant
11.6
44.5
85
82
J43.9
ICD-10 Finland
Emphysema, unspecified
19.3
43.7
67
38
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
6.1
41.4
121
230
GD1AD
NOMESCO Finland
Thorax CT examination
7.6
41.1
101
151
J45
ICD-10 Finland
Asthma
5.4
40.2
131
284
C03CA01
ATC
furosemide; systemic
2.9
39.7
382
2019
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
39.7
214
752
J01FA10
ATC
azithromycin; systemic
2.8
39.1
409
2270
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
23.2
38.9
56
26
R96
ICPC
Asthma
5.4
38.2
125
271
J01FA15
ATC
telithromycin; oral
5.1
38.0
130
297
TGC00
NOMESCO Finland
Bronchial lavation
10.7
37.4
74
76
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.1
35.8
258
1110
J01CA04
ATC
amoxicillin; systemic
3.1
35.4
589
4233
XG466
NOMESCO Finland
Sleep oxymetry
9.9
35.4
73
81
R03AK11
ATC
formoterol and fluticasone; inhalant
13.3
32.3
57
46
R05CB01
ATC
acetylcysteine; inhalant, oral
13.8
31.1
54
42
R03BA08
ATC
ciclesonide; inhalant
5.0
30.8
105
236
J20
ICD-10 Finland
Acute bronchitis
4.6
30.7
115
286
348
Kela drug reimbursment
Roflumilast
+∞
30.4
29
*
A02BC02
ATC
pantoprazole; systemic
2.6
30.2
519
3581
A01AB09
ATC
miconazole; local oral
4.2
29.2
121
331
J42
ICD-10 Finland
Unspecified chronic bronchitis
16.8
28.9
46
29
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
6.2
28.4
80
143
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
26.7
310
1698
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
26.5
208
912
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
+∞
26.2
25
*
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
8.5
26.2
58
73
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
26.1
127
398
R03BB02
ATC
oxitropium bromide; inhalant
46.1
25.7
31
7
R05
ICPC
Cough
2.8
25.6
201
882
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.8
25.2
89
207
R03DX07
ATC
roflumilast; oral
+∞
25.1
24
*
A07AA02
ATC
nystatin; oral
4.4
25.0
97
248
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
24.5
211
971
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.9
24.1
56
76
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
19.9
24.1
36
19
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
+∞
24.1
23
*
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
247.8
23.8
24
*
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
27.8
23.7
32
12
49300
ICD-8 Finland
Asthma, bronchiale
8.2
23.4
53
69
M05BA04
ATC
alendronic acid; oral
3.7
23.4
111
339
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
22.9
188
836
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
19.7
22.8
34
18
R5140
NOMESCO Finland
Monitoring the use of the aid
3.4
22.5
117
384
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
12.8
22.0
39
32
J01MA02
ATC
ciprofloxacin; systemic
2.2
22.0
344
2114
J01DA01
ATC
[U] cefalexin; systemic
2.2
21.9
471
3332
XG474
NOMESCO Finland
Exhalation nntrogen oxide
8.9
21.9
47
56
R03AC18
ATC
indacaterol; inhalant
40.0
21.8
27
7
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.3
21.7
251
1339
R81
ICPC
Pneumonia
5.9
21.7
62
113
R28
ICPC
Limited function/disability (R)
12.9
21.0
37
30
C07AB07
ATC
bisoprolol; oral
2.1
21.0
433
2980
A02BC03
ATC
lansoprazole; oral
2.3
21.0
265
1469
R03DC01
ATC
zafirlukast; oral
10.3
20.8
41
42
J15.1
ICD-10 Finland
Pneumonia due to Pseudomonas
79.2
20.8
23
*
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
7.9
20.5
47
63
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
20.4
267
1501
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
20.4
184
860
A02BC05
ATC
esomeprazole; systemic
2.1
20.2
319
1946
TDM10
NOMESCO Finland
Puncture of maxillary antrum
6.0
19.6
55
98
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
6.8
19.4
49
76
R01AD09
ATC
mometasone; nasal
2.1
19.1
293
1754
J01GB01
ATC
tobramycin; inhalant, parenteral
+∞
18.8
18
*
J96.0
ICD-10 Finland
Acute respiratory failure
14.7
18.7
31
22
J01DB01
ATC
cefalexin; oral
2.2
18.5
569
4513
A03
ICPC
Fever
3.0
18.4
113
416
WX725
NOMESCO Finland
Noninvasive ventilation
5.2
17.9
57
118
R01AD08
ATC
fluticasone; nasal
2.3
17.9
194
984
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.8
17.8
45
70
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
21.5
17.4
25
12
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.2
17.2
211
1134
J43.8
ICD-10 Finland
Other emphysema
92.2
16.6
18
*
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
92.2
16.6
18
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
28.3
16.6
22
8
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
16.5
178
899
J15.8
ICD-10 Finland
Other bacterial pneumonia
20.6
16.5
24
12
J01DA08
ATC
[U] cefaclor; oral
3.6
16.2
75
223
R29
ICPC
Respiratory symptom/complaint other
4.1
16.2
65
171
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
34.2
15.8
20
6
N02AX02
ATC
tramadol; systemic, rectal
1.9
15.8
339
2266
N02AA05
ATC
oxycodone; systemic
2.4
15.6
155
746
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.9
15.6
329
2183
J01DA06
ATC
[U] cefuroxime; systemic
2.5
15.5
131
582
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
9.0
15.3
32
37
R50.9
ICD-10 Finland
Fever, unspecified
2.5
15.3
132
592
A02BC01
ATC
omeprazole; systemic
2.0
15.3
239
1413
A02BA02
ATC
ranitidine; systemic
2.1
15.2
194
1053
R05FB02
ATC
cough suppressants and expectorants
1.9
15.2
304
1975
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.4
15.1
138
636
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
11.2
15.1
28
26
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
6.6
14.9
38
60
R03BB06
ATC
glycopyrronium bromide; inhalant
57.9
14.8
17
*
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.5
14.8
53
125
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
14.6
126
565
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
6.0
14.6
40
70
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
14.5
148
722
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
15.8
14.5
23
15
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.5
14.3
68
207
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
13.9
228
1362
WZC30
NOMESCO Finland
Teaching
2.5
13.9
117
518
R01AD01
ATC
beclometasone; nasal
2.4
13.7
121
548
R78
ICPC
Acute bronchitis/bronchiolitis
6.5
13.7
35
56
SPAT1325
SPAT
Vaccination
1.9
13.6
292
1920
N05CF01
ATC
zopiclone; oral
1.9
13.5
275
1775
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.4
13.4
67
212
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.5
13.4
65
201
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.4
13.3
65
203
G47.3
ICD-10 Finland
Sleep apnoea
2.2
13.0
153
795
J01FF01
ATC
clindamycin; systemic
2.0
13.0
202
1178
R05FA02
ATC
opium derivatives and expectorants; systemic
1.8
13.0
287
1899
R06AE07
ATC
cetirizine; oral
1.9
12.9
268
1733
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
4.5
12.9
45
104
WX722
NOMESCO Finland
PEEP
3.8
12.8
54
149
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
12.8
239
1489
R05
ICD-10 Finland
Cough
2.1
12.8
159
843
J02AC01
ATC
fluconazole; systemic
1.9
12.8
230
1416
SPAT1254
SPAT
Administration of medicine
2.2
12.8
143
724
J01DC02
ATC
cefuroxime; systemic
3.8
12.7
55
155
WW200
NOMESCO Finland
Immunization
5.7
12.7
36
66
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
9.5
12.6
25
27
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
24.8
12.5
17
7
A01AB10
ATC
natamycin; local oral
5.2
12.5
38
76
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
12.4
108
485
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
12.4
171
949
E88.0
ICD-10 Finland
Disorders of plasma-protein metabolism, not elsewhere classified
38.2
12.2
15
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.0
12.1
194
1139
R74
ICPC
Upper respiratory infection acute
2.2
12.1
141
727
XG405
NOMESCO Finland
Education on PEF monitoring
8.9
12.1
25
29
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
12.1
78
295
N07BA03
ATC
varenicline; oral
5.3
12.0
36
71
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
11.9
112
522
H02AB09
ATC
hydrocortisone; systemic
6.0
11.9
32
55
R01AD05
ATC
budesonide; nasal
3.1
11.8
66
224
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.6
11.7
53
156
I50.0
ICD-10 Finland
Congestive heart failure
2.5
11.6
94
403
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.4
11.6
34
65
R06.2
ICD-10 Finland
Wheezing
4.3
11.6
42
101
N03AX16
ATC
pregabalin; oral
2.0
11.6
175
1001
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
+∞
11.5
11
*
J31.0
ICD-10 Finland
Chronic rhinitis
3.1
11.5
62
209
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.3
11.4
42
103
ZXA10
NOMESCO Finland
Bilateral
2.0
11.2
163
920
R24
ICPC
Haemoptysis
17.4
11.2
17
10
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.3
11.2
56
178
RK250
NOMESCO Finland
NA
25.5
11.2
15
6
49101
ICD-8 Finland
Chronic bronchitis, Nonpurulenta (simplex)
25.5
11.2
15
6
R4110
NOMESCO Finland
Physiotherapy
1.9
11.1
199
1213
A02BA03
ATC
famotidine; systemic
3.4
11.0
52
159
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
44.0
10.9
13
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
10.9
190
1146
A01AB04
ATC
amphotericin B; local oral
3.2
10.9
58
194
N06AB04
ATC
citalopram; systemic
2.0
10.8
153
853
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
10.8
122
616
A46
ICD-10 Finland
Erysipelas
2.1
10.8
128
660
R03BB05
ATC
aclidinium bromide; inhalant
28.5
10.8
14
5
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
8.2
10.7
23
29
ZX120
NOMESCO Finland
Intravenous
2.5
10.6
86
371
XQ800
NOMESCO Finland
Prick test
3.5
10.6
48
142
WX892
NOMESCO Finland
Monitored bed care
2.7
10.6
74
295
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
14.5
10.5
17
12
49102
ICD-8 Finland
Chronic bronchitis, Purulenta
111.5
10.4
11
*
R03AL05
ATC
formoterol and aclidinium bromide; inhalant
111.5
10.4
11
*
J01XB01
ATC
colistin; inhalant, parenteral
+∞
10.4
10
*
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
16.3
10.4
16
10
J02AC03
ATC
voriconazole; systemic
33.0
10.4
13
*
RK320
NOMESCO Finland
NA
10.8
10.3
19
18
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
10.1
177
1066
48509
ICD-8 Finland
Bronchopneumonia, unspecified
10.2
10.1
19
19
1240
FHL
Bronchoscopy
5.9
10.0
27
47
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.6
10.0
44
127
F2680
NOMESCO Finland
NA
40.6
10.0
12
*
XG460
NOMESCO Finland
Short time oxymetry
5.3
9.9
29
56
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
8.9
9.8
20
23
A02BA04
ATC
nizatidine; systemic
2.4
9.8
81
354
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
6.3
9.8
25
41
R03BB07
ATC
umeclidinium bromide; inhalant
11.6
9.6
17
15
A28
ICPC
Limited function/disability NOS
1.9
9.5
156
915
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
101.3
9.4
10
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
17.8
9.4
14
8
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
9.4
58
213
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
9.4
88
408
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
4.7
9.2
30
66
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
4.5
9.1
31
71
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
15.8
9.1
14
9
L28
ICPC
Limited function/disability (L)
1.9
9.0
146
850
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
8.8
8.8
18
21
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
8.8
258
1808
N02BE01
ATC
paracetamol; systemic, rectal
1.8
8.8
585
5103
R03AC19
ATC
olodaterol; inhalant
50.6
8.7
10
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
7.8
8.7
19
25
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
8.6
124
690
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
8.6
63
258
R03BC01
ATC
cromoglicic acid; inhalant
9.1
8.6
17
19
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
9.1
8.6
17
19
A06AD11
ATC
lactulose; oral
1.9
8.6
144
849
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.1
8.5
46
156
Z72.0
ICD-10 Finland
Tobacco use
5.2
8.5
25
49
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
4.5
8.5
29
67
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
20.3
8.5
12
6
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
8.4
60
240
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
8.4
67
288
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.9
8.4
52
191
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.2
8.4
30
73
RK110
NOMESCO Finland
NA
10.9
8.3
15
14
J37.0
ICD-10 Finland
Chronic laryngitis
3.9
8.2
32
84
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
14.7
8.2
13
9
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.0
8.2
102
536
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.8
8.2
26
56
R60.0
ICD-10 Finland
Localized oedema
2.1
8.1
98
510
R06AX13
ATC
loratadine; oral
2.2
8.1
82
395
L03
ICPC
Low back symptom/complaint
1.8
8.0
145
876
R79
ICPC
Chronic bronchitis
22.3
8.0
11
5
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
8.0
40
129
P01AB01
ATC
metronidazole; oral, rectal
1.6
8.0
248
1753
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.2
7.9
29
72
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
7.9
115
641
C08DA01
ATC
verapamil; systemic
2.9
7.8
46
166
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
7.8
228
1585
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
45.5
7.7
9
*
L04AX01
ATC
azathioprine; systemic
3.3
7.6
37
117
J20.0
ICD-10 Finland
Acute bronchitis due to Mycoplasma pneumoniae
8.2
7.6
16
20
6BA02
NOMESCO Finland
NA
25.3
7.6
10
*
49099
ICD-8 Finland
Bronchitis, unspecified
6.3
7.6
19
31
R05CB03
ATC
carbocisteine; oral
3.9
7.4
29
77
B96.5
ICD-10 Finland
Pseudomonas (aeruginosa) as the cause of diseases classified to other chapters
80.9
7.4
8
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.8
7.3
29
78
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.2
7.3
37
121
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
11.0
7.3
13
12
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
7.3
7
*
B05XA03
ATC
sodium chloride; parenteral
+∞
7.3
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
7.3
90
474
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
7.3
67
307
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
15.9
7.2
11
7
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
7.4
7.2
16
22
R05CB02
ATC
bromhexine; systemic
4.9
7.2
22
46
C01DA14
ATC
isosorbide mononitrate; oral
1.7
7.2
176
1163
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
30.3
7.2
9
*
N03AX12
ATC
gabapentin; oral
1.9
7.2
109
619
M54.5
ICD-10 Finland
Low back pain
1.6
7.2
194
1318
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.5
7.1
53
220
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.0
7.1
88
460
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
6.1
7.1
18
30
B01AC04
ATC
clopidogrel; oral
1.7
7.1
149
940
R03DA05
ATC
aminophylline; systemic, rectal
8.9
7.1
14
16
R03DA54
ATC
theophylline, combinations excl. psycholeptics; systemic
4.8
7.1
22
47
N05BA01
ATC
diazepam; systemic, rectal
1.9
7.0
101
562
D07AA02
ATC
hydrocortisone; topical
2.0
7.0
84
437
R99
ICPC
Respiratory disease other
5.0
7.0
21
43
R01AD11
ATC
triamcinolone; nasal
2.4
7.0
58
255
R11
ICD-10 Finland
Nausea and vomiting
2.3
6.9
61
277
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.9
217
1529
48609
ICD-8 Finland
Pneumonia, unspecified
7.6
6.9
15
20
4939A
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA SINE EXACERBATIONE]
13.9
6.9
11
8
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.8
282
2127
WX721
NOMESCO Finland
Oxygen concentrator therapy
40.4
6.8
8
*
SPAT1263
SPAT
Sampling
1.5
6.7
293
2228
J86.9
ICD-10 Finland
Pyothorax without fistula
7.3
6.7
15
21
120
Kela drug reimbursment
Hypogammaglobulinaemia
22.7
6.7
9
*
J01MA11
ATC
grepafloxacin; oral
22.7
6.7
9
*
J98.1
ICD-10 Finland
Pulmonary collapse
7.9
6.6
14
18
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.2
6.6
66
318
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
6.6
78
402
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
10.1
6.5
12
12
N05BA02
ATC
chlordiazepoxide; systemic
4.2
6.5
23
56
B02AA02
ATC
tranexamic acid; systemic
2.0
6.5
78
406
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
6.5
274
2067
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.3
6.5
22
52
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.5
225
1623
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
6.4
107
627
N06AX11
ATC
mirtazapine; oral
1.6
6.4
199
1392
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.4
57
259
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
6.4
100
573
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
6.4
215
1536
SPAT1260
SPAT
Consultation of another employee
1.7
6.3
124
765
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
6.3
135
856
J32.4
ICD-10 Finland
Chronic pansinusitis
5.6
6.3
17
31
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.4
6.3
28
84
AA1AD
NOMESCO Finland
CT of head and brain
1.6
6.3
187
1298
S22.3
ICD-10 Finland
Fracture of rib
2.3
6.2
53
236
B44.8
ICD-10 Finland
Other forms of aspergillosis
26.9
6.2
8
*
JN4BD
NOMESCO Finland
Extensive body CT
1.9
6.2
91
510
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
6.4
6.2
15
24
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.8
6.2
16
28
4221
FHL
Polyp removal from the nasal cavity, sinus puncture or irrigation, or biopsy under general anesthesia or operating room
12.6
6.1
10
8
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.1
120
741
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
6.1
40
156
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
6.0
36
133

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
216
84
34.34
322.46
5.5
2.3
—
—
—
0
0
96
32
33.77
147.92
2.0
1.2
2.2
1.2
u/ml
0.37
76
18
163
272
7.20
97.28
2.1
1.2
333.3
152.3
u/ml
2.66
155
245
107
112
10.81
93.57
7.0
2.4
—
—
—
0
0
48
20
25.40
67.80
5.2
2.2
—
—
—
0
0
239
754
4.04
66.52
2.8
1.5
—
—
—
0
0
57
40
15.22
63.57
1.5
1.3
0.4
0.4
g/l
0.15
40
28
57
40
15.22
63.57
1.5
1.3
7.2
7.0
g/l
0.07
40
29
57
40
15.22
63.57
1.5
1.3
2.6
2.6
g/l
0.01
37
29
155
364
5.00
63.13
6.7
10.7
25.3
24.3
mmol/l
2.81
140
337
56
41
14.57
60.98
1.6
1.3
—
—
—
0
0
67
75
9.63
55.27
1.6
1.3
0.9
0.8
g/l
0.16
47
59
175
499
4.17
55.23
4.3
5.1
—
—
—
0
0
240
850
3.56
55.22
7.1
7.8
5.4
5.0
kpa
4.55
228
816
239
851
3.53
54.45
7.1
7.8
9.5
12.0
kpa
18.36
226
818
163
447
4.29
54.16
3.6
2.8
10.4
10.9
g/l
0.53
154
403
427
2155
3.01
53.35
7.8
4.1
—
—
—
0
0
166
469
4.17
52.92
7.6
3.4
5.5
5.1
kpa
4.52
156
435
164
464
4.15
52.14
7.3
3.4
7.4
7.4
ph
0.13
11
50
38
17
23.37
52.05
1.6
1.4
—
—
—
0
0
155
423
4.27
51.71
1.8
1.4
—
—
—
0
0
235
858
3.42
51.11
7.2
7.7
2.2
1.0
mmol/l
3.60
192
668
137
348
4.51
50.12
2.1
1.9
1.0
1.6
g/l
2.03
127
311
415
2148
2.85
48.11
10.3
5.2
—
—
—
0
0
505
2907
2.87
47.53
12.1
5.7
8.6
9.0
%
1.77
489
2693
504
2902
2.86
47.34
11.5
5.4
2.6
2.9
%
1.66
487
2672
522
3073
2.86
46.78
10.9
5.2
0.7
0.6
e9/l
17.07
479
2608
503
2906
2.84
46.72
11.5
5.3
63.0
58.2
%
15.38
484
2694
523
3087
2.86
46.54
10.9
5.2
0.0
0.0
e9/l
4.85
481
2632
533
3178
2.87
46.50
11.2
5.3
0.2
0.2
e9/l
0.36
489
2759
493
2824
2.82
46.47
11.4
5.4
0.6
0.6
%
1.58
477
2612
132
347
4.33
46.03
7.6
3.5
—
—
—
0
0
506
2956
2.81
45.59
11.8
5.6
22.0
26.4
%
17.03
488
2717
526
3142
2.82
45.24
10.9
5.3
1.8
1.9
e9/l
1.04
487
2724
149
443
3.88
43.78
2.3
1.5
—
—
—
0
0
242
1005
2.98
41.26
2.5
2.1
—
—
—
0
0
201
778
3.09
38.57
7.0
8.2
92.7
95.6
%
6.15
194
754
75
145
5.58
37.56
1.6
1.1
—
—
—
0
0
552
3627
2.54
35.16
13.4
8.6
5.6
4.2
e9/l
21.43
508
3154
41
46
9.32
33.57
1.2
2.3
1.4
1.0
e9/l
1.19
15
28
38
9
44.09
31.12
1.6
1.1
—
—
—
0
0
183
776
2.74
28.95
2.3
1.7
—
—
—
0
0
99
305
3.55
27.10
8.8
3.8
25.9
24.8
mmol/l
2.37
94
281
71
173
4.39
26.97
5.8
2.7
25.2
24.5
mmol/l
0.56
64
145
66
154
4.57
26.47
5.4
2.5
7.3
8.0
kpa
2.52
61
140
113
393
3.17
25.43
8.9
7.7
26.1
24.8
mmol/l
2.92
113
387
392
2469
2.11
24.15
4.2
3.1
1925.6
1836.5
ng/l
0.13
354
2137
55
123
4.72
23.21
4.0
2.2
—
—
—
0
0
152
654
2.62
22.97
7.1
7.2
1.6
1.5
mmol/l
0.31
141
624
159
705
2.55
22.56
4.3
3.6
6.4
5.7
kpa
7.67
154
684
140
585
2.67
22.41
1.6
1.5
—
—
—
0
0
213
1083
2.30
22.26
4.2
3.3
0.8
0.8
mmol/l
0.18
198
1002
155
694
2.51
21.47
4.4
3.6
3.6
1.8
mmol/l
5.09
140
548
29
37
8.08
21.39
1.5
2.3
1175.0
842.3
e6/l
0.72
20
14
203
1027
2.29
21.37
2.0
1.5
2.9
2.6
g/l
1.04
152
579
238
1312
2.14
20.10
2.1
1.6
1.3
1.5
mg/l
0.36
198
1017
140
622
2.50
19.61
8.1
8.5
—
—
—
0
0
53
136
4.09
18.76
8.1
4.0
—
—
—
0
0
39
78
5.20
18.72
2.1
1.6
—
—
—
0
0
39
78
5.20
18.72
2.1
1.6
—
—
—
0
0
39
78
5.20
18.72
2.1
1.6
—
—
—
0
0
39
78
5.20
18.72
2.1
1.6
—
—
—
0
0
90
339
2.85
17.43
3.6
3.7
25.6
23.9
mmol/l
4.38
83
303
148
715
2.30
17.06
8.3
8.4
121.8
118.8
g/l
0.94
142
695
17
14
12.37
16.96
1.8
1.4
—
—
—
0
0
113
485
2.54
16.92
4.6
3.8
2.7
0.6
%
0.77
27
120
484
3550
1.86
16.87
8.7
6.4
10.0
12.3
umol/l
6.06
465
3365
97
400
2.61
15.74
9.6
11.5
—
—
—
0
0
432
3105
1.81
15.62
5.3
4.9
32.0
34.7
g/l
15.64
402
2876
112
504
2.41
15.09
4.9
4.1
0.1
0.1
%
0.00
34
154
117
544
2.34
14.63
4.8
4.0
1.6
0.9
%
0.60
36
174
476
3567
1.78
14.53
9.9
7.2
1.2
1.2
mmol/l
1.29
401
2981
445
3272
1.77
14.49
8.9
6.2
1.2
1.2
mmol/l
1.70
405
2923
133
660
2.21
14.23
7.3
7.3
11.2
11.5
mmol/l
0.17
125
629
22
34
6.62
13.70
1.3
2.6
13.6
17.6
%
0.57
14
17
132
663
2.18
13.68
2.6
2.2
0.2
0.2
g/l
0.68
123
614
139
718
2.12
13.40
3.8
3.1
268.4
241.8
ng/l
0.17
129
659
83
343
2.58
13.38
2.5
1.8
1.2
2.3
ug/l
0.52
75
296
291
1925
1.79
13.37
2.8
2.2
3.4
3.1
mg/l
1.36
248
1629
248
1576
1.82
12.97
9.9
6.5
—
—
—
0
0
135
704
2.09
12.66
1.3
1.3
463.8
512.7
titre
0.17
32
159
102
480
2.28
12.35
5.1
4.1
0.1
0.8
%
0.48
29
131
48
154
3.25
12.25
11.0
4.3
5.4
5.0
kpa
2.72
48
148
48
154
3.25
12.25
10.9
4.3
3.1
2.9
mmol/l
0.21
42
100
48
154
3.25
12.25
11.0
4.3
8.0
8.3
kpa
1.06
48
148
58
211
2.88
11.95
5.0
3.6
—
—
—
0
0
97
453
2.29
11.95
9.5
9.7
91.2
94.2
%
2.97
97
453
235
1502
1.79
11.90
3.4
2.9
510.6
563.3
mosm/kgh2o
4.19
211
1274
416
3129
1.66
11.44
11.8
11.2
1.3
1.4
inr
0.76
110
853
16
22
7.40
11.01
3.4
1.5
55.1
58.7
ug/l
0.08
16
22
42
133
3.27
10.96
3.7
2.2
15.6
16.2
%
0.34
18
64
198
1230
1.80
10.92
6.8
4.5
—
—
—
0
0
191
1179
1.80
10.74
2.6
2.6
9.7
12.4
umol/l
5.75
173
1086
171
1029
1.83
10.43
2.8
2.6
18.0
22.4
%
3.68
151
865
220
1427
1.74
10.39
7.5
4.1
164.6
291.5
ng/l
0.94
187
1230
385
2887
1.62
10.38
6.9
4.1
47.4
56.0
ng/l
0.29
308
2253
248
1671
1.69
10.16
6.3
4.0
85.4
83.7
%
0.41
238
1634
175
1074
1.80
9.96
2.7
2.6
2.1
2.3
g/l
1.80
162
989
570
4734
1.64
9.85
8.4
4.1
21.2
14.3
mm/h
12.85
536
4284
297
2118
1.62
9.65
3.2
2.5
50.4
56.8
u/l
3.02
274
1948
21
45
4.76
9.33
1.4
1.2
—
—
—
0
0
111
604
1.97
9.15
3.9
2.9
4.8
4.4
kpa
0.85
105
585
34
107
3.27
8.99
1.1
1.4
—
—
—
0
0
283
2025
1.60
8.93
4.5
3.4
0.7
0.5
e6/l
0.42
228
1570
48
186
2.68
8.82
1.5
1.7
—
—
—
0
0
55
230
2.49
8.66
6.5
7.6
1.2
1.4
mmol/l
0.70
47
205
18
36
5.09
8.65
1.6
3.4
—
—
—
0
0
156
966
1.76
8.52
7.2
5.7
1.1
1.0
mmol/l
2.61
143
878
536
4467
1.56
8.39
6.5
5.0
450.2
2671.9
e6/l
—
5
84
268
1917
1.59
8.36
4.4
3.4
—
—
—
0
0
360
2754
1.54
8.33
17.3
9.8
0.0
0.0
e9/l
1.16
305
2241
344
2609
1.54
8.26
3.4
2.8
133.7
156.8
ug/l
1.28
311
2335
34
115
3.04
8.01
3.8
3.0
64.2
59.9
%
0.97
34
115
297
2199
1.54
7.87
4.7
3.5
119.5
88.7
e6/l
0.27
244
1734
33
111
3.05
7.85
3.7
2.6
6.3
4.6
e9/l
1.95
33
111
493
4071
1.52
7.75
8.6
4.9
6.7
6.9
mmol/l
0.67
474
3838
60
275
2.27
7.73
1.9
3.7
146.4
79.2
mg/l
0.33
39
228
13
21
6.27
7.73
2.2
1.2
—
—
—
0
0
592
5089
1.56
7.69
12.9
7.6
85.2
81.9
u/l
0.67
568
4724
150
949
1.71
7.53
2.1
2.6
1.8
1.8
%
0.35
119
856
15
29
5.25
7.47
3.1
2.1
743.9
2029.0
u/ml
0.80
15
29
38
144
2.72
7.32
2.7
1.9
128.2
128.3
g/l
0.01
19
106
59
276
2.22
7.25
1.9
3.7
26.9
90.9
mg/l
0.84
39
231
225
1592
1.57
7.19
3.4
2.7
4.6
4.6
e6/l
0.00
206
1405
113
669
1.80
7.14
2.2
3.0
64.6
66.1
g/l
1.19
96
593
99
563
1.86
7.12
2.8
2.0
301.7
380.5
nmol/l
3.05
94
515
21
56
3.82
7.11
1.3
1.8
—
—
—
0
0
284
2119
1.52
7.11
5.5
4.1
7.4
7.4
ph
0.03
66
386
27
86
3.21
7.04
3.2
1.8
88.7
89.7
%
0.47
27
86
45
190
2.45
6.98
1.4
1.5
287.0
260.7
ug/g
0.39
27
113
121
736
1.75
6.97
5.5
4.6
—
—
—
0
0
298
2261
1.49
6.82
3.8
3.4
—
—
—
0
0
17
40
4.32
6.77
3.3
3.0
—
—
—
0
0
89
498
1.88
6.73
9.1
6.7
26.0
24.3
mmol/l
2.56
84
473
171
1151
1.61
6.71
2.7
1.9
30.5
29.9
s
0.39
164
1114
118
723
1.74
6.62
2.0
2.6
72.7
66.6
e9/l
1.13
85
581
16
37
4.39
6.51
1.9
3.8
7.4
7.4
ph
—
6
8
97
566
1.81
6.43
2.0
2.7
—
—
—
0
0
319
2479
1.46
6.37
5.5
4.0
86.2
120.9
e6/l
0.40
255
1853
35
139
2.58
6.18
1.4
1.3
59.6
61.0
mmol/l
0.07
28
119
26
89
2.98
6.04
3.7
5.1
—
—
—
0
0
169
1165
1.56
5.94
4.1
3.2
2.0
1.7
e6/l
0.21
84
669
241
1800
1.48
5.79
3.7
3.0
3971.5
7747.7
umol/l
0.70
198
1511
28
103
2.78
5.74
1.3
1.3
49398.2
133357.1
e6/l
0.56
13
52
30
115
2.67
5.69
1.3
1.3
1608.7
1180.8
e6/l
0.29
22
74
114
723
1.67
5.62
3.4
2.6
6.0
6.6
ug/l
0.20
91
625
19
56
3.45
5.61
1.3
1.2
—
—
—
0
0
44
204
2.22
5.57
1.7
4.0
—
—
—
0
0
550
6138
0.70
5.57
5.1
5.4
2.4
2.6
mmol/l
6.31
481
5491
18
52
3.52
5.47
3.4
2.8
—
—
—
0
0
70
388
1.88
5.47
5.1
3.3
27.3
24.9
mmol/l
3.08
70
374
523
4528
1.41
5.41
6.2
4.6
—
—
—
0
0
119
1757
0.62
5.37
2.9
3.3
0.6
0.8
ug/l
2.21
83
1249
131
871
1.60
5.35
1.4
1.2
—
—
—
0
0
37
163
2.33
5.28
2.5
2.8
—
—
—
0
0
119
1748
0.63
5.23
3.2
3.3
—
—
—
0
0
535
5977
0.71
5.20
4.6
4.8
4.3
4.4
mmol/l
2.21
469
5391
30
121
2.53
5.17
3.0
4.5
1.3
1.5
%
0.19
24
99
21
70
3.05
5.13
3.3
3.4
—
—
—
0
0
35
153
2.34
5.09
2.2
3.4
538.4
2381.5
u/ml
0.57
30
146
530
5915
0.72
4.96
4.7
4.8
1.5
1.4
mmol/l
0.63
460
5275
26
100
2.65
4.93
1.3
1.4
—
—
—
0
0
18
56
3.26
4.91
1.7
1.8
12.9
11.0
%
0.63
18
56
69
399
1.80
4.74
5.1
2.8
5.6
4.1
e9/l
2.04
51
289
218
1657
1.43
4.64
2.9
2.5
—
—
—
0
0
21
76
2.81
4.47
3.7
3.7
63.8
52.0
%
1.25
16
55
111
741
1.57
4.45
2.5
2.9
10.0
9.5
umol/l
0.06
92
664
23
88
2.66
4.43
1.3
1.3
—
—
—
0
0
157
1138
1.47
4.28
29.7
31.2
1.7
1.4
inr
1.14
20
150
129
902
1.51
4.19
1.3
1.2
58.9
37.6
iu/ml
0.37
46
275
89
572
1.62
4.18
3.6
4.1
93.8
94.9
ng/l
0.04
74
494
555
6088
0.74
4.07
5.3
5.1
6.1
6.1
mmol/l
0.34
492
5381
5
208
0.24
4.02
1.0
1.5
—
—
—
0
0
269
2188
1.34
3.67
3.1
2.6
—
—
—
0
0
294
2424
1.33
3.65
3.3
3.6
2.3
2.3
mmol/l
0.88
248
2077
52
300
1.78
3.64
5.9
4.2
—
—
—
0
0
24
104
2.35
3.62
1.5
1.6
—
—
—
0
0
8
13
6.20
3.50
9.4
12.6
1171.0
948.9
nmol/l
—
8
13
8
13
6.20
3.50
13.4
17.0
1679.7
1713.6
nmol/l
—
8
13
52
305
1.75
3.46
1.2
1.3
—
—
—
0
0
121
870
1.46
3.43
1.3
1.2
39.8
15.1
u/ml
0.83
35
297
523
5730
0.77
3.33
4.2
4.3
1.2
1.3
mmol/l
0.17
450
5063
86
581
1.54
3.30
1.8
2.0
569.3
151.4
ug/g
0.79
63
456
537
5854
0.77
3.22
6.7
6.6
42.3
41.0
mmol/mol
2.33
482
5312
62
391
1.63
3.18
1.4
1.9
1.9
1.5
g/l
1.97
54
341
114
826
1.44
3.11
3.2
4.3
4.4
25.5
ug/l
1.46
104
701
17
68
2.53
3.05
1.2
1.3
265.4
273.8
mosm/kgh2o
—
10
47
29
147
2.01
3.03
3.1
2.8
35.7
32.9
umol/l
0.22
24
118
259
2148
1.30
2.98
2.8
2.2
231.7
238.5
u/l
0.02
236
2007
260
3081
0.77
2.96
4.8
5.7
2.6
5.1
ug/l
0.95
215
2706
11
35
3.17
2.94
1.7
1.9
8.8
9.3
mmol/l
0.16
11
30
27
135
2.03
2.93
2.7
2.0
67.4
59.7
%
0.76
27
135
262
2190
1.29
2.81
6.5
4.2
—
—
—
0
0
354
3077
1.26
2.74
2.3
2.1
91.1
93.8
pmol/l
0.51
216
1567
8
19
4.24
2.68
2.3
2.0
—
—
—
0
0
180
1442
1.32
2.64
3.5
3.1
2.5
2.5
mmol/l
5.65
159
1259
5
8
6.28
2.37
2.0
5.9
15.1
15.4
ml/dl
—
5
8
144
1137
1.32
2.34
1.3
1.2
0.9
1.4
u/ml
0.95
30
287
11
41
2.71
2.28
1.1
1.0
—
—
—
0
0
9
29
3.13
2.23
1.3
1.1
—
—
—
0
0
13
54
2.43
2.20
1.3
1.2
—
—
—
0
0
444
4854
0.82
2.20
52.1
23.0
326.3
331.7
g/l
24.73
437
4818
11
42
2.64
2.19
1.1
1.0
—
—
—
0
0
10
37
2.72
2.11
1.1
1.2
4.1
3.4
mmol/l
—
10
31
81
595
1.40
2.09
5.4
3.8
1.2
1.2
mmol/l
1.32
75
511
131
1631
0.77
2.09
1.6
1.6
1.4
1.3
mmol/l
0.75
109
1327
5
10
5.02
2.07
1.6
1.2
—
—
—
0
0
638
6702
0.80
2.04
56.6
25.2
129.9
132.7
g/l
4.44
628
6558
638
6701
0.80
2.03
56.2
25.0
4.4
4.4
e12/l
0.11
623
6462
638
6700
0.80
2.02
56.0
24.9
91.7
91.8
fl
0.16
628
6562
638
6700
0.80
2.02
55.9
24.9
30.0
30.5
pg
8.21
628
6561
638
6699
0.80
2.01
56.1
25.0
269.3
235.1
e9/l
20.78
623
6489
639
6702
0.80
1.94
56.2
25.0
8.5
6.9
e9/l
41.43
623
6463
222
1899
1.23
1.87
1.7
1.6
18.5
20.5
nmol/l
1.28
190
1592
11
46
2.41
1.85
2.1
3.5
32.2
33.9
%
—
5
18
285
2506
1.21
1.82
2.4
2.4
—
—
—
0
0
20
109
1.86
1.78
1.5
1.4
—
—
—
0
0
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
5
13
3.86
1.71
6.2
5.6
—
—
—
0
0
11
48
2.31
1.71
2.2
2.0
—
—
—
0
0
56
401
1.43
1.70
1.2
1.2
—
—
—
0
0
67
496
1.38
1.69
1.8
1.5
—
—
—
0
0
65
480
1.38
1.67
1.8
1.5
—
—
—
0
0
6
19
3.17
1.66
1.0
1.1
—
—
—
0
0
6
19
3.17
1.66
1.2
1.2
—
—
—
0
0
11
49
2.26
1.64
1.5
2.9
—
—
—
0
0
14
71
1.99
1.54
1.1
1.1
3.1
8.3
u/ml
—
9
30
14
71
1.99
1.54
1.0
1.2
—
—
—
0
0
73
558
1.34
1.52
4.7
4.2
—
—
—
0
0
5
15
3.35
1.52
1.0
1.6
—
—
—
0
0
6
21
2.87
1.50
1.0
1.0
—
—
—
0
0
8
167
0.47
1.48
1.6
1.4
—
—
—
0
0
17
94
1.83
1.48
1.6
1.4
120.7
108.1
u/ml
—
7
14
40
278
1.46
1.45
1.9
2.9
0.5
0.3
g/l
0.73
17
101
12
59
2.05
1.44
1.3
1.2
—
—
—
0
0
12
59
2.05
1.44
1.3
1.3
—
—
—
0
0
11
212
0.51
1.41
11.3
11.8
—
—
—
0
0
18
104
1.75
1.38
1.2
1.1
—
—
—
0
0
5
17
2.95
1.36
1.0
1.1
—
—
—
0
0
5
17
2.95
1.36
3.0
1.5
—
—
—
0
0
191
1660
1.20
1.35
2.0
1.8
1107.5
1186.5
nmol/l
0.42
144
1245
6
25
2.41
1.24
1.2
2.4
—
—
—
0
0
13
70
1.87
1.24
1.2
1.3
—
—
—
0
0
11
202
0.54
1.24
1.3
1.2
—
—
—
0
0
9
45
2.01
1.23
1.0
1.2
—
—
—
0
0
43
314
1.39
1.23
1.7
1.3
—
—
—
0
0
626
6503
0.85
1.22
18.0
11.2
24.2
24.9
u/l
0.26
609
6199
6
126
0.47
1.17
1.0
1.3
—
—
—
0
0
338
3117
1.14
1.10
4.8
4.1
0.0
0.0
estimate
0.00
80
597
38
278
1.38
1.09
3.2
3.0
4.1
4.3
pmol/l
0.49
29
236
342
3162
1.14
1.06
4.9
4.1
0.0
0.0
estimate
0.50
79
577
30
212
1.43
1.05
4.1
3.3
0.8
0.8
nmol/l
0.01
24
164
51
394
1.31
1.05
2.7
2.5
—
—
—
0
0
334
3087
1.14
1.04
4.5
4.3
—
—
—
0
0
336
3111
1.13
1.01
6.7
5.5
0.0
0.0
estimate
0.00
84
591
28
390
0.71
1.01
7.4
4.0
—
—
—
0
0
34
249
1.38
0.99
2.0
2.5
34.2
37.2
g/l
2.09
28
204
14
84
1.68
0.98
1.1
1.2
—
—
—
0
0
437
4620
0.89
0.98
5.8
4.4
—
—
—
0
0
5
23
2.18
0.98
4.8
3.0
—
—
—
0
0
7
36
1.95
0.97
7.0
2.2
—
—
—
0
0
26
182
1.44
0.97
2.1
1.6
—
—
—
0
0
15
93
1.62
0.94
1.1
1.2
373.6
335.3
u/ml
—
7
52
13
78
1.68
0.92
1.8
1.1
—
—
—
0
0
6
28
2.15
0.91
1.2
1.0
—
—
—
0
0
123
1408
0.85
0.90
5.5
4.6
1.0
1.0
kg/l
0.68
26
211
12
71
1.70
0.89
1.3
1.2
—
—
—
0
0
637
6562
0.88
0.87
45.6
20.6
4.0
4.0
mmol/l
0.35
625
6365
14
88
1.60
0.84
1.1
1.3
—
—
—
0
0
183
1649
1.14
0.83
4.4
3.8
—
—
—
0
0
539
5602
0.89
0.83
5.3
4.7
1.9
2.3
mu/l
0.89
491
4949
86
730
1.20
0.83
1.3
1.3
—
—
—
0
0
8
46
1.75
0.82
1.3
1.2
—
—
—
0
0
8
47
1.71
0.81
2.5
2.3
—
—
—
0
0
637
6551
0.88
0.79
45.3
20.4
138.9
139.6
mmol/l
8.51
625
6360
13
82
1.59
0.78
1.4
1.5
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
119.7
—
0
20
18
124
1.46
0.75
1.2
1.2
—
—
—
0
0
636
6176
1.13
0.75
47.6
16.7
29.4
27.8
mg/l
0.73
604
5022
5
24
2.09
0.74
1.8
1.5
—
—
—
0
0
614
6315
0.90
0.71
34.9
16.4
—
—
—
0
0
10
157
0.63
0.69
7.4
3.8
38.2
32.3
mg/l
—
5
105
13
85
1.54
0.69
2.9
2.6
—
—
—
0
0
12
77
1.57
0.68
1.0
1.0
—
—
—
0
0
12
77
1.57
0.68
1.3
1.3
—
0.7
—
0
6
10
61
1.65
0.68
1.2
1.1
—
—
—
0
0
7
42
1.67
0.68
1.0
2.0
—
—
—
0
0
12
179
0.67
0.67
1.3
1.2
—
—
—
0
0
5
28
1.79
0.66
1.4
1.6
—
—
—
0
0
5
28
1.79
0.66
1.6
1.9
—
—
—
0
0
6
102
0.59
0.62
1.2
1.2
—
—
—
0
0
10
63
1.59
0.62
1.4
1.1
—
—
—
0
0
39
477
0.81
0.61
2.7
2.3
13.7
11.9
nmol/l
0.64
30
406
17
232
0.73
0.60
8.9
4.8
—
—
—
0
0
9
61
1.48
0.54
1.6
1.8
—
—
—
0
0
6
39
1.54
0.53
1.7
1.2
—
—
—
0
0
11
157
0.70
0.51
2.0
2.5
—
—
—
0
0
39
465
0.83
0.50
3.9
3.4
—
—
—
0
0
10
68
1.48
0.47
1.3
1.3
—
—
—
0
0
8
119
0.67
0.46
1.1
1.8
—
—
—
0
0
161
1497
1.09
0.45
4.8
4.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
5.8
—
0.6
—
0
16
0
17
0.00
0.40
0.0
1.1
—
1690.3
—
0
17
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
154
1647
0.92
0.40
1.7
1.8
51639828.2
8837289.0
pmol/l
0.38
122
1324
5
35
1.43
0.39
1.4
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
17
134
1.27
0.37
1.3
1.2
2.1
2.9
u/ml
—
5
15
6
44
1.37
0.34
5.5
3.3
76.0
104.6
nmol/l
—
6
44
66
597
1.11
0.33
1.2
1.4
—
—
—
0
0
50
559
0.89
0.32
1.6
1.5
—
—
—
0
0
14
111
1.27
0.30
4.9
3.3
—
—
—
0
0
31
355
0.87
0.29
1.3
1.3
—
—
—
0
0
11
85
1.30
0.28
1.6
2.3
—
—
—
0
0
481
4908
0.95
0.27
45.4
20.6
14.7
13.9
%
18.66
473
4793
465
4552
1.05
0.27
4.1
3.8
15.1
15.1
pmol/l
0.10
413
3996
35
310
1.13
0.26
1.3
1.3
—
—
—
0
0
223
2309
0.95
0.23
4.0
3.9
13.6
8.0
mg/mmol
0.67
138
1477
5
38
1.32
0.23
1.0
1.5
—
—
—
0
0
26
228
1.14
0.23
1.1
1.1
—
30.2
—
0
6
5
42
1.19
0.21
1.4
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
5
43
1.16
0.21
1.4
1.3
—
—
—
0
0
5
43
1.16
0.21
1.4
1.3
—
—
—
0
0
11
89
1.24
0.21
1.1
2.2
—
—
—
0
0
182
1755
1.05
0.20
5.2
4.3
0.0
0.0
estimate
0.00
74
563
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
143
1491
0.95
0.20
1.3
1.3
—
—
—
0
0
10
81
1.24
0.19
1.2
1.2
—
—
—
0
0
24
214
1.13
0.17
1.4
1.3
—
—
—
0
0
12
142
0.84
0.17
1.0
1.1
—
—
—
0
0
533
5273
1.03
0.14
41.0
18.7
38.0
38.4
%
0.35
318
3233
14
160
0.87
0.14
1.3
1.1
—
—
—
0
0
18
160
1.13
0.14
1.4
1.7
18239.1
17140.5
e6/l
0.05
13
114
24
261
0.92
0.11
1.7
2.1
—
—
—
0
0
86
893
0.96
0.11
1.4
1.4
—
—
—
0
0
10
115
0.87
0.10
1.4
1.7
—
—
—
0
0
5
44
1.14
0.10
1.4
1.3
—
—
—
0
0
5
44
1.14
0.10
1.4
1.3
—
—
—
0
0
5
45
1.11
0.10
2.4
1.1
—
—
—
0
0
6
56
1.07
0.08
1.8
2.1
1.2
2.0
ug/l
—
6
45
6
57
1.05
0.08
1.8
2.0
1.5
3.1
ug/l
—
6
48
13
117
1.11
0.08
1.0
1.1
—
—
—
0
0
7
65
1.08
0.08
1.7
1.4
—
—
—
0
0
12
108
1.11
0.07
3.7
2.6
—
—
—
0
0
39
375
1.04
0.06
3.2
2.9
—
—
—
0
0
40
415
0.96
0.05
5.0
2.8
0.5
0.3
e6/l
0.20
40
406
220
2177
1.01
0.05
3.2
3.3
774.9
386.8
mg/l
0.45
146
1400
61
625
0.97
0.04
4.2
3.5
—
—
—
0
0
15
142
1.06
0.02
1.1
1.6
—
—
—
0
0
36
369
0.97
0.02
2.4
2.6
—
14.2
—
0
9
12
124
0.97
0.00
1.3
1.6
—
—
—
0
0
17
166
1.02
0.00
1.7
1.2
—
—
—
0
0
28
275
1.02
0.00
1.4
1.2
106.0
136.7
iu/ml
—
9
94
33
326
1.01
0.00
1.2
1.4
—
44.2
—
0
17
220
2202
1.00
0.00
3.2
3.1
6.5
7.2
mmol/l
1.37
179
1774
10
103
0.97
0.00
1.1
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
7
78
0.90
0.00
1.0
1.0
—
—
—
0
0
19
190
1.00
0.00
2.2
2.4
255.9
84.3
ug/min
—
9
111
0
9
0.00
0.00
0.0
1.0
—
18.9
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
8
85
0.94
0.00
1.4
1.8
261.6
300.6
mu/l
—
8
77
0
8
0.00
0.00
0.0
1.3
—
1.9
—
0
8
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
0.00
1.2
1.1
1.3
1.5
nmol/l
—
5
49
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint COPD_OPPORTUNIST_INFECTIONS and mortality.

Females

Parameter HR [95% CI] p-value
COPD_OPPORTUNIST_INFECTIONS 2.652 [2.3, 3.05] < 0.001
Birth year 1.0 [0.99, 1.01] 0.953

During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 1389 females with COPD_OPPORTUNIST_INFECTIONS died.

Males

Parameter HR [95% CI] p-value
COPD_OPPORTUNIST_INFECTIONS 2.541 [2.21, 2.92] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1245 out of 2143 males with COPD_OPPORTUNIST_INFECTIONS died.

Mortality risk

Mortality risk for people of age

years, who have COPD_OPPORTUNIST_INFECTIONS.

N-year risk Females Males
1 0.272% 0.412%
5 1.622% 2.284%
10 4.163% 5.977%
15 8.101% 11.142%
20 14.53% 18.826%

Relationships between endpoints

↥

Index endpoint: COPD_OPPORTUNIST_INFECTIONS – COPD related to chronic (opportunist) infections

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data