This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Eosinophilia
D3_EOSINOPHILIA
Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
569 |
4. Check minimum number of eventsNone |
569 |
5. Include endpointsNone |
569 |
6. Filter based on genotype QC (FinnGen only) |
569 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D72
- Name in latin
- Eosinophilia
Similar endpoints
↥List of similar endpoints to
Eosinophilia
based on the number of shared cases.
Similar with more cases:
- Eosinophilic disease (BM)
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 569 | 302 | 267 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 56.84 | 52.68 | 61.55 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 503
- Matched controls
- 5027
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D72.1
ICD-10 Finland
Eosinophilia
4503599627370496.0
323.0
490
*
H02AB06
ATC
prednisolone; systemic
5.4
66.3
359
1594
XW000
NOMESCO Finland
Bone marrow biopsy
20.9
59.0
89
51
J45.9
ICD-10 Finland
Asthma, unspecified
5.6
55.5
196
513
J45.1
ICD-10 Finland
Nonallergic asthma
9.7
54.8
119
155
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
5.0
48.8
194
565
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
47.2
315
1482
J32.4
ICD-10 Finland
Chronic pansinusitis
32.6
44.2
58
20
R03DC03
ATC
montelukast; oral
5.0
42.8
163
443
J45.0
ICD-10 Finland
Predominantly allergic asthma
6.4
39.5
114
221
R03AK08
ATC
formoterol and beclometasone; inhalant
12.7
37.3
68
61
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.3
37.3
81
102
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
7.8
35.8
87
131
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
360.2
34.3
34
*
J33.0
ICD-10 Finland
Polyp of nasal cavity
13.8
33.7
59
48
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
348.7
33.3
33
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.3
32.8
226
991
R03AC02
ATC
salbutamol; inhalant
3.1
32.2
328
1884
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
13.9
31.6
55
44
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
7.9
31.5
75
109
R03BB04
ATC
tiotropium bromide; inhalant
5.3
31.3
104
235
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.9
31.0
93
186
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
12.7
31.0
56
49
XG474
NOMESCO Finland
Exhalation nntrogen oxide
11.7
28.8
54
51
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.2
28.2
80
148
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.8
24.8
120
385
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
71.0
24.0
27
*
ZXE00
NOMESCO Finland
One hour or less
2.6
23.0
246
1342
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.9
22.9
79
183
R01AD08
ATC
fluticasone; nasal
2.8
22.8
194
925
R03BA05
ATC
fluticasone; inhalant
3.2
22.7
139
532
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
22.3
111
363
J45
ICD-10 Finland
Asthma
4.3
21.8
87
233
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
21.7
155
655
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.3
21.3
85
228
DHB20
NOMESCO Finland
Polypectomy of internal nose
17.6
21.2
33
20
R03BA08
ATC
ciclesonide; inhalant
4.5
20.9
79
201
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.1
19.8
49
75
R01AD09
ATC
mometasone; nasal
2.4
19.5
262
1569
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.6
19.4
46
66
XQ800
NOMESCO Finland
Prick test
4.6
19.3
70
170
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.9
19.1
85
250
R50.9
ICD-10 Finland
Fever, unspecified
3.3
18.9
107
379
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
18.8
290
1848
WZC30
NOMESCO Finland
Teaching
3.4
18.5
101
350
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
18.3
77
216
H02AB04
ATC
methylprednisolone; systemic
3.1
17.6
110
420
TGC00
NOMESCO Finland
Bronchial lavation
9.4
17.5
36
41
A02BC02
ATC
pantoprazole; systemic
2.3
17.3
348
2471
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
6.4
17.3
46
78
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.3
17.0
66
171
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
16.8
135
603
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
8.0
16.7
38
51
J01MA12
ATC
levofloxacin; systemic
2.8
16.7
121
507
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.2
16.6
45
78
R06AE07
ATC
cetirizine; oral
2.2
16.5
246
1508
J33.8
ICD-10 Finland
Other polyp of sinus
9.7
16.4
33
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
15.7
174
918
J46
ICD-10 Finland
Status asthmaticus
6.7
15.7
40
64
H02AB07
ATC
prednisone; oral
2.9
15.6
103
405
R03AC13
ATC
formoterol; inhalant
5.3
15.5
48
98
J01MA14
ATC
moxifloxacin; systemic
3.7
15.3
69
205
R03AK07
ATC
formoterol and budesonide; inhalant
2.6
15.1
126
570
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.5
14.9
133
623
R96
ICPC
Asthma
3.6
14.8
69
210
A02BC01
ATC
omeprazole; systemic
2.3
14.7
166
876
J45.8
ICD-10 Finland
Mixed asthma
5.9
14.2
40
73
R03AC12
ATC
salmeterol; inhalant
4.9
14.0
46
101
J01AA02
ATC
doxycycline; systemic
2.3
13.8
395
3107
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.4
13.7
41
81
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
13.7
203
1209
Z88.6
ICD-10 Finland
Personal history of allergy to analgesic agent
77.3
13.6
15
*
R01AD12
ATC
fluticasone furoate; nasal
2.2
13.6
176
986
DPA30
NOMESCO Finland
Sphenotomy
18.9
13.5
20
11
ZX112
NOMESCO Finland
Subcutaneous
7.9
13.4
30
40
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.5
13.3
117
539
R03BA01
ATC
beclometasone; inhalant
2.8
13.0
94
387
WX002
NOMESCO Finland
Sedation and analgesia
2.4
13.0
120
570
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.5
12.8
61
189
H02AB09
ATC
hydrocortisone; systemic
7.3
12.8
30
43
M05BA04
ATC
alendronic acid; oral
3.6
12.7
58
174
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
12.7
93
387
2883X
ICD-9 Finland
Diseases of white blood cells, Eosinophilia[EOSINOPHILIA, NUD]
+∞
12.5
12
*
XG410
NOMESCO Finland
Flow-volume spirometry
5.0
12.2
39
83
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
12.2
106
483
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
16.4
12.2
19
12
J33.9
ICD-10 Finland
Nasal polyp, unspecified
16.4
12.2
19
12
J47
ICD-10 Finland
Bronchiectasis
12.8
12.2
21
17
R05
ICD-10 Finland
Cough
2.4
12.1
121
595
E0000UV
ATC
NA
2.0
12.0
212
1337
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.5
11.9
100
449
R03AK11
ATC
formoterol and fluticasone; inhalant
5.6
11.9
34
64
3028
Kela drug reimbursment
Mepolizumab
66.5
11.7
13
*
R03DX09
ATC
mepolizumab; parenteral
122.7
11.5
12
*
C03CA01
ATC
furosemide; systemic
2.2
11.4
142
772
R03DC01
ATC
zafirlukast; oral
8.6
11.4
24
29
J01DB01
ATC
cefalexin; oral
2.2
11.2
413
3411
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.3
11.2
41
101
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
20.6
11.2
16
8
R06AE09
ATC
levocetirizine; oral
2.5
11.0
92
410
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
28.7
10.8
14
5
JN4BD
NOMESCO Finland
Extensive body CT
2.7
10.7
74
297
297
Kela drug reimbursment
NA
61.3
10.7
12
*
XX3DW
NOMESCO Finland
Time consuming IT work
2.8
10.4
68
263
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.4
10.1
49
155
R06.0
ICD-10 Finland
Dyspnoea
2.1
10.0
136
761
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.4
9.8
47
147
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.4
9.7
46
143
D07AC01
ATC
betamethasone; topical
1.9
9.7
180
1137
ZXA10
NOMESCO Finland
Bilateral
2.2
9.6
108
556
R01AD01
ATC
beclometasone; nasal
2.4
9.6
88
409
L29.9
ICD-10 Finland
Pruritus, unspecified
7.4
9.6
22
31
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.3
9.5
28
55
J01FF01
ATC
clindamycin; systemic
2.0
9.5
147
864
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
9.5
94
455
R03BA02
ATC
budesonide; inhalant
2.2
9.4
102
516
GD1AD
NOMESCO Finland
Thorax CT examination
4.3
9.3
34
84
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.8
9.3
61
235
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.9
9.1
56
209
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.5
9.0
42
129
R06AX27
ATC
desloratadine; oral
1.9
8.9
147
883
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
8.8
115
628
J31.0
ICD-10 Finland
Chronic rhinitis
2.9
8.8
54
200
UJF32
NOMESCO Finland
Coloscopy
2.0
8.7
135
793
R06AX22
ATC
ebastine; oral
2.2
8.7
93
466
L04AA06
ATC
mycophenolic acid; systemic
8.4
8.6
18
22
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
16.6
8.6
13
8
R03DA04
ATC
theophylline; systemic, rectal
3.4
8.6
41
129
Z3231
NOMESCO Finland
Registered nurse
1.9
8.2
139
839
Z49.1
ICD-10 Finland
Extracorporeal dialysis
9.1
8.1
16
18
J01CA04
ATC
amoxicillin; systemic
1.9
8.1
400
3387
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
10.3
8.1
15
15
J01FA06
ATC
roxithromycin; oral
1.8
8.0
200
1372
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.0
210
1465
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.0
7.9
109
605
J01FA09
ATC
clarithromycin; systemic
1.8
7.9
166
1079
S97
ICPC
Chronic ulcer skin
3.4
7.8
36
110
A02BC05
ATC
esomeprazole; systemic
1.8
7.8
196
1343
D07AD01
ATC
clobetasol; topical
2.2
7.8
86
438
R01AD11
ATC
triamcinolone; nasal
2.7
7.7
52
204
UJF30
NOMESCO Finland
Ileoscopy through colon
2.6
7.7
56
231
B01AA03
ATC
warfarin; systemic
2.1
7.7
98
528
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
25.4
7.6
10
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
7.6
55
227
UDM02
NOMESCO Finland
Sinoscopy
5.2
7.5
22
44
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
5.2
7.5
22
44
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.5
180
1215
C07AB07
ATC
bisoprolol; oral
1.7
7.4
223
1605
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.4
7.4
60
264
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
8.5
7.4
15
18
J01FA10
ATC
azithromycin; systemic
1.7
7.4
285
2203
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.3
7.3
36
116
3027
Kela drug reimbursment
Benralizumab
+∞
7.3
7
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
7.3
50
200
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
5.9
7.3
19
33
UDC00
NOMESCO Finland
Ear microscopy
2.8
7.3
44
164
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
7.3
61
271
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
16.0
7.3
11
7
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.2
116
684
D02AE01
ATC
carbamide; topical
3.0
7.2
41
145
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
5.4
7.1
20
38
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.8
7.1
22
47
L04AX01
ATC
azathioprine; systemic
3.6
7.0
30
87
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
7.0
57
249
R03AC03
ATC
terbutaline; inhalant
2.1
7.0
80
411
D07AC13
ATC
mometasone; topical
1.8
7.0
146
939
R06AX13
ATC
loratadine; oral
2.1
6.9
83
437
XG405
NOMESCO Finland
Education on PEF monitoring
8.4
6.9
14
17
B03XA02
ATC
darbepoetin alfa; parenteral
5.8
6.8
18
32
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.8
6.8
21
45
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
6.8
209
1506
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.3
6.7
19
37
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.6
6.7
16
25
SPAT1254
SPAT
Administration of medicine
2.1
6.6
77
399
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
6.6
200
1430
L50.9
ICD-10 Finland
Urticaria, unspecified
3.8
6.6
26
71
L28.1
ICD-10 Finland
Prurigo nodularis
10.2
6.6
12
12
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.6
104
609
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
6.5
38
138
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.6
6.5
48
198
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.6
6.5
28
82
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.4
6.5
18
34
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
5.8
6.5
17
30
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
6.5
48
200
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
6.4
66
326
WW200
NOMESCO Finland
Immunization
4.7
6.3
20
44
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.8
6.3
38
142
A46
ICD-10 Finland
Erysipelas
2.1
6.3
71
365
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
6.3
30
96
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
6.3
6
*
I42.3
ICD-10 Finland
Endomyocardial (eosinophilic) disease
+∞
6.3
6
*
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.1
6.2
22
55
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
6.1
52
234
R01AD05
ATC
budesonide; nasal
2.4
6.1
50
222
L01XX05
ATC
hydroxycarbamide; oral
12.7
6.1
10
8
SPAT1263
SPAT
Sampling
1.6
6.1
205
1498
R06.2
ICD-10 Finland
Wheezing
3.1
6.1
31
104
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
8.7
6.1
12
14
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
10.2
6.1
11
11
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: D3_EOSINOPHILIA – Eosinophilia
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).