pinguecula: A yellowish thickened lesion on the conjunctiva near the cornea representing a benign degenerative change in the conjunctiva caused by the leakage and deposition of certain blood proteins through the permeable capillaries near the limbus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
779 |
4. Check minimum number of eventsNone |
779 |
5. Include endpointsNone |
779 |
6. Filter based on genotype QC (FinnGen only) |
779 |
Control definitions (FinnGen only)
- Control exclude
- H7_CONJUNCTIVA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H11
- Name in latin
- Degenerationes et deposita conjunctivae
Similar endpoints
↥List of similar endpoints to
conjunctival degenerations and deposits
based on the number of shared cases.
Similar with more cases:
- Other disorders of conjunctiva
- Disorders of conjunctiva
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5600 | 3529 | 2024 |
| Only index persons | 5007 | 3200 | 1807 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 53.72 | 53.94 | 53.55 |
| Only index persons | 52.74 | 52.84 | 52.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 779 | 501 | 278 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.12 |
| Median age at first event (years) | 52.82 | 51.22 | 55.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 702
- Matched controls
- 7017
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
+∞
323.0
683
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
87.2
475
2054
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
131.4
67.2
71
6
H04.10
ICD-10 Finland
Dry eye syndrome
7.2
64.1
171
300
S01GX01
ATC
cromoglicic acid; ophthalmic
4.6
45.1
181
497
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
13.0
34.6
62
52
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.5
28.5
312
1683
CF2S4
NOMESCO Finland
Photography of conjunctiva
216.1
20.7
21
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
20.6
158
674
3725A
ICD-9 Finland
Disorders of conjunctiva, Conjunctival degenerations and deposits
+∞
19.9
19
*
H11.0
ICD-10 Finland
Pterygium
41.4
19.6
24
6
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
5.5
18.0
54
105
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
15.3
17.3
28
19
A02BC03
ATC
lansoprazole; oral
2.1
17.2
247
1428
H02AB06
ATC
prednisolone; systemic
2.0
17.1
355
2382
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.7
16.1
56
128
H10.4
ICD-10 Finland
Chronic conjunctivitis
48.7
16.1
19
*
S01GX02
ATC
levocabastine; ophthalmic
4.8
15.8
53
117
S01GX05
ATC
lodoxamide; ophthalmic
19.8
15.6
23
12
S01BC03
ATC
diclofenac; ophthalmic
7.7
15.6
36
49
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.9
15.4
51
111
S01KA02
ATC
hypromellose; ophthalmic
7.4
15.2
36
51
N02AX02
ATC
tramadol; systemic, rectal
1.9
14.5
318
2134
H16.0
ICD-10 Finland
Corneal ulcer
4.8
14.3
48
106
3401
FHL
Removal of local modification or taking a specimen in the operating room
+∞
13.6
13
*
G44.2
ICD-10 Finland
Tension-type headache
2.5
13.5
111
484
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
13.4
231
1405
H57.1
ICD-10 Finland
Ocular pain
5.4
13.4
40
78
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
12.5
212
1277
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
12.5
193
1121
N03AX16
ATC
pregabalin; oral
2.0
12.5
185
1061
P01BA02
ATC
hydroxychloroquine; oral
2.7
12.1
89
364
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.4
12.1
110
504
R01AD01
ATC
beclometasone; nasal
2.3
11.8
118
567
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
11.7
167
938
H16.9
ICD-10 Finland
Keratitis, unspecified
8.8
11.6
24
28
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
11.4
103
470
M01AX17
ATC
nimesulide; oral
1.9
11.2
196
1186
M54.5
ICD-10 Finland
Low back pain
1.8
11.1
228
1460
H15.1
ICD-10 Finland
Episcleritis
11.4
11.1
20
18
R42
ICD-10 Finland
Dizziness and giddiness
2.0
11.0
168
967
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.9
11.0
44
117
CFA20
NOMESCO Finland
Biopsy of conjunctiva
44.0
10.9
13
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
5.2
10.9
33
66
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
10.8
270
1837
E0000UV
ATC
NA
1.8
10.6
272
1862
F01
ICPC
Eye pain
5.2
10.6
32
64
S01AD03
ATC
aciclovir; ophthalmic
4.2
10.6
39
96
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.6
10.6
47
137
A02BC01
ATC
omeprazole; systemic
1.8
10.4
214
1365
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
10.4
95
436
SPAT1153
SPAT
Removal of sutures
1.8
10.4
237
1565
A02BC02
ATC
pantoprazole; systemic
1.7
10.2
455
3647
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.5
10.1
47
142
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
10.1
464
3748
H01.0
ICD-10 Finland
Blepharitis
3.2
9.8
50
162
A02BC05
ATC
esomeprazole; systemic
1.7
9.7
299
2147
J05AB01
ATC
aciclovir; systemic
1.9
9.6
154
899
H19.3
ICD-10 Finland
Keratitis and keratoconjunctivitis in other diseases classified elsewhere
30.5
9.4
12
*
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.6
9.2
349
2639
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.8
9.2
176
1087
S01GX04
ATC
nedocromil; ophthalmic
7.9
9.2
20
26
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
9.1
71
300
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
5.5
9.1
26
49
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
9.0
123
672
N06AA09
ATC
amitriptyline; systemic
2.2
9.0
93
453
S01XA18
ATC
ciclosporin; ophthalmic
18.9
9.0
13
7
M03BX02
ATC
tizanidine; oral
1.6
8.9
413
3281
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
8.9
148
870
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.9
252
1755
M54.6
ICD-10 Finland
Pain in thoracic spine
2.9
8.9
55
202
CD2S4
NOMESCO Finland
Photography of eye
12.7
8.9
15
12
J02AC01
ATC
fluconazole; systemic
1.7
8.9
273
1945
UJF32
NOMESCO Finland
Coloscopy
1.8
8.8
194
1254
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
8.7
244
1693
S01GX08
ATC
ketotifen; ophthalmic
5.2
8.7
26
52
D86.0
ICD-10 Finland
Sarcoidosis of lung
7.8
8.7
19
25
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
8.6
131
749
K07.60
ICD-10 Finland
Snapping jaw
3.4
8.4
40
124
J01FA10
ATC
azithromycin; systemic
1.6
8.4
370
2886
M01AH05
ATC
etoricoxib; oral
1.6
8.3
392
3101
M48.0
ICD-10 Finland
Spinal stenosis
2.1
8.3
95
485
R52.2
ICD-10 Finland
Other chronic pain
4.2
8.3
30
74
R03AC02
ATC
salbutamol; inhalant
1.6
8.2
344
2644
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
8.1
64
271
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.0
178
1149
KMAK
NOMESCO Finland
NA
1.6
8.0
336
2576
Z00.0
ICD-10 Finland
General medical examination
1.9
7.9
137
813
H02AB04
ATC
methylprednisolone; systemic
2.0
7.8
107
585
N05CF01
ATC
zopiclone; oral
1.6
7.8
234
1641
Z71.8
ICD-10 Finland
Other specified counselling
1.8
7.8
156
975
RF420
NOMESCO Finland
NA
6.0
7.7
20
34
H11.4
ICD-10 Finland
Other conjunctival vascular disorders and cysts
45.5
7.7
9
*
R01AD12
ATC
fluticasone furoate; nasal
1.7
7.7
179
1173
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.2
7.7
39
128
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
7.6
68
310
R07.3
ICD-10 Finland
Other chest pain
2.2
7.6
77
374
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
7.5
143
876
R01AD09
ATC
mometasone; nasal
1.6
7.4
282
2099
H00.1
ICD-10 Finland
Chalazion
3.3
7.4
35
109
R51.80
ICD-10 Finland
Headache
2.0
7.4
100
547
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
7.3
129
773
CCC00
NOMESCO Finland
Occlusion of lacrimal punctum or canaliculus
+∞
7.3
7
*
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
5.5
7.3
20
37
D07CC01
ATC
betamethasone and antibiotics; topical
2.0
7.2
91
482
A07EC01
ATC
sulfasalazine; oral, rectal
2.3
7.2
67
311
A02BA02
ATC
ranitidine; systemic
1.7
7.2
147
923
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.8
7.1
43
159
CG2S4
NOMESCO Finland
Photography of cornea
12.2
7.1
12
10
SPAT1216
SPAT
Assessment of functional ability
1.9
7.1
117
684
M25.5
ICD-10 Finland
Pain in joint
1.6
7.1
190
1292
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
7.0
103
579
R1250
NOMESCO Finland
Evaluation of functional capability
4.5
7.0
23
52
R03AC03
ATC
terbutaline; inhalant
2.0
6.9
96
526
J01DA01
ATC
[U] cefalexin; systemic
1.5
6.9
413
3393
S06.0
ICD-10 Finland
Concussion
2.1
6.9
76
381
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
8.4
6.8
14
17
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
6.8
76
383
F70
ICPC
Conjunctivitis infectious
3.9
6.8
26
68
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
6.8
118
700
S01GX09
ATC
olopatadine; ophthalmic
5.4
6.8
19
36
H16.2
ICD-10 Finland
Keratoconjunctivitis
9.4
6.8
13
14
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
6.8
244
1782
H11.8
ICD-10 Finland
Other specified disorders of conjunctiva
40.4
6.8
8
*
D07AB02
ATC
hydrocortisone butyrate; topical
1.6
6.8
183
1242
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.1
6.7
73
365
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
6.7
117
695
R05
ICD-10 Finland
Cough
1.8
6.7
133
826
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.5
6.7
48
197
RF120
NOMESCO Finland
NA
6.5
6.7
16
25
J01AA02
ATC
doxycycline; systemic
1.6
6.7
529
4621
RF410
NOMESCO Finland
NA
6.0
6.6
17
29
N03AX12
ATC
gabapentin; oral
1.9
6.6
108
628
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.5
6.6
29
86
D07AC13
ATC
mometasone; topical
1.6
6.6
191
1321
J01FA06
ATC
roxithromycin; oral
1.5
6.6
272
2048
K59.09
ICD-10 Finland
Constipation, unspecified
2.4
6.5
53
232
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
6.5
78
407
R03BA02
ATC
budesonide; inhalant
1.8
6.5
109
643
R06AX22
ATC
ebastine; oral
1.9
6.5
105
609
XCK00
NOMESCO Finland
Perimetry
2.4
6.4
54
238
J01CA04
ATC
amoxicillin; systemic
1.6
6.4
532
4666
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
6.4
62
295
H10.5
ICD-10 Finland
Blepharoconjunctivitis
6.0
6.3
16
27
RD211
NOMESCO Finland
NA
2.6
6.3
42
165
C05AA08
ATC
fluocortolone; rectal, topical
1.8
6.3
104
610
R03BA01
ATC
beclometasone; inhalant
1.9
6.3
95
540
CGE50
NOMESCO Finland
Excision of pterygium
+∞
6.3
6
*
L04AX01
ATC
azathioprine; systemic
3.1
6.2
32
107
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
6.2
397
3278
SPAT1263
SPAT
Sampling
1.5
6.2
279
2139
N06AX11
ATC
mirtazapine; oral
1.6
6.1
206
1474
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.1
87
484
R06AE07
ATC
cetirizine; oral
1.5
6.1
274
2089
E000006
ATC
NA
2.4
6.1
50
221
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.1
265
2010
M79.7
ICD-10 Finland
Fibromyalgia
3.1
6.0
31
104
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.6
6.0
158
1062
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
6.1
6.0
15
25
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONJUNCTDEGDEPOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONJUNCTDEGDEPOT | 1.186 [1.08, 1.3] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.208 |
During the follow-up period (1.1.1998 — 31.12.2019), 778 out of 3296 females with H7_CONJUNCTDEGDEPOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONJUNCTDEGDEPOT | 1.055 [0.94, 1.19] | 0.384 |
| Birth year | 0.986 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 474 out of 1823 males with H7_CONJUNCTDEGDEPOT died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONJUNCTDEGDEPOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.185% |
| 5 | 0.716% | 1.11% |
| 10 | 1.788% | 3.068% |
| 15 | 3.429% | 5.735% |
| 20 | 5.936% | 9.686% |
Relationships between endpoints
↥Index endpoint: H7_CONJUNCTDEGDEPOT – conjunctival degenerations and deposits
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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