No definition available.
Inflammation of lacrimal passages (acute and unspecified)
DOID EFO Endpoint Browser PheWeb
H7_LACRIMINFLAMACU
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
684 |
4. Check minimum number of eventsNone |
684 |
5. Include endpointsNone |
684 |
6. Filter based on genotype QC (FinnGen only) |
659 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Inflammatio viarum lacrimalium acuta sive non specificata
Similar endpoints
↥List of similar endpoints to
Inflammation of lacrimal passages (acute and unspecified)
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5708 | 4089 | 1592 |
| Only index persons | 4945 | 3555 | 1390 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.04 |
| Only index persons | 0.11 | 0.13 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 58.12 | 62.11 | 48.00 |
| Only index persons | 56.05 | 59.83 | 46.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 659 | 486 | 173 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.08 |
| Median age at first event (years) | 57.69 | 56.78 | 60.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 684
- Matched controls
- 6840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
13586.2
307.7
656
9
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
585.9
301.1
278
8
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
863.1
202.3
189
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
124.9
116
*
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
105.0
98
*
H04.10
ICD-10 Finland
Dry eye syndrome
7.5
84.5
136
218
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.5
84.2
402
1635
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
801.2
74.7
72
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
751.6
70.4
68
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
63.5
60
*
H04.0
ICD-10 Finland
Dacryoadenitis
311.8
57.2
57
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
5.2
40.2
89
190
H01.0
ICD-10 Finland
Blepharitis
6.1
39.9
74
134
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.8
39.6
98
230
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
34.9
370
2092
F03
ICPC
Eye discharge
4.5
30.6
80
195
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.5
30.6
79
191
H02.3
ICD-10 Finland
Blepharochalasis
33.4
29.4
38
12
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.3
26.9
73
183
J01DB01
ATC
cefalexin; oral
3.6
26.3
608
4734
H04.2
ICD-10 Finland
Epiphora
62.6
26.2
30
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
25.9
164
700
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
25.2
24
*
S01AX11
ATC
[U] ofloxacin
5.2
24.8
53
109
F29
ICPC
Eye symptom/complaint other
3.4
24.5
96
311
UDM02
NOMESCO Finland
Sinoscopy
6.9
24.1
38
58
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
22.5
100
349
H57.1
ICD-10 Finland
Ocular pain
5.1
20.6
45
94
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
41.4
19.6
24
6
S01ED01
ATC
timolol; ophthalmic
4.9
18.9
43
93
CCA30
NOMESCO Finland
Incision of lacrimal sac
+∞
18.8
18
*
36803
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryocystitis acuta, phlegmonosa
+∞
18.8
18
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
195.1
18.6
19
*
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
17.8
17
*
R01AD09
ATC
mometasone; nasal
2.0
16.3
333
2235
J01FF01
ATC
clindamycin; systemic
2.1
16.1
208
1186
S01EE04
ATC
travoprost; ophthalmic
7.1
15.8
24
35
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
+∞
15.7
15
*
H02.4
ICD-10 Finland
Ptosis of eyelid
27.0
15.7
21
8
S01XA18
ATC
ciclosporin; ophthalmic
163.6
15.5
16
*
S01ED51
ATC
timolol, combinations; ophthalmic
3.0
15.5
73
262
H02AB06
ATC
prednisolone; systemic
1.9
14.3
333
2301
114
Kela drug reimbursment
Glaucoma
2.7
14.2
82
329
A02BC02
ATC
pantoprazole; systemic
1.9
14.0
466
3598
H00.1
ICD-10 Finland
Chalazion
5.6
13.6
26
48
CCC50
NOMESCO Finland
Dacryocystectomy
+∞
13.6
13
*
H10
ICD-10 Finland
Conjunctivitis
2.9
13.1
65
240
R06AE07
ATC
cetirizine; oral
1.8
12.9
314
2177
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
12.7
152
835
H02.1
ICD-10 Finland
Ectropion of eyelid
71.2
12.6
14
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
12.5
361
2626
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
12.3
181
1068
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
4.5
12.0
29
66
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.7
12.0
39
111
XCK00
NOMESCO Finland
Perimetry
3.0
11.8
53
185
L04AX03
ATC
methotrexate; systemic
2.5
11.6
80
349
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
11.5
11
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.3
256
1721
S01EX03, ,
ATC
4.7
11.3
26
57
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
11.1
89
415
S01EE01
ATC
latanoprost; ophthalmic
2.8
11.1
57
215
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
10.9
329
2390
L01BA01
ATC
methotrexate; systemic
3.6
10.9
36
104
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
5.4
10.6
21
40
R51.80
ICD-10 Finland
Headache
2.0
10.6
122
656
H02AB04
ATC
methylprednisolone; systemic
2.1
10.6
108
556
3753A
ICD-9 Finland
Disorders of lachrymal system, Acute and unspecified inflammation of lachrymal passages
+∞
10.4
10
*
CC1CB
NOMESCO Finland
Dacryocystography
+∞
10.4
10
*
S01EA05
ATC
brimonidine; ophthalmic
4.3
10.4
27
65
ZXA05
NOMESCO Finland
Left side
1.9
10.3
174
1065
H00.00
ICD-10 Finland
Hordeolum
3.4
9.8
36
111
S01AA01
ATC
chloramphenicol; ophthalmic
3.0
9.8
45
159
J01DA01
ATC
[U] cefalexin
1.7
9.8
423
3347
H16.0
ICD-10 Finland
Corneal ulcer
3.1
9.7
40
133
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
9.6
131
747
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.0
9.6
111
598
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
15.3
9.5
15
10
J01FA10
ATC
azithromycin; systemic
1.7
9.5
391
3043
H04
ICD-10 Finland
Disorders of lacrimal system
+∞
9.4
9
*
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.3
130
746
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.4
9.3
34
105
XCH00
NOMESCO Finland
Eye pressure measurement
3.1
9.3
38
126
S01AD03
ATC
aciclovir; ophthalmic
3.7
9.2
29
81
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.6
9.2
30
86
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.3
9.2
74
346
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
9.1
91
464
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
9.1
278
2001
J01AA02
ATC
doxycycline; systemic
1.8
9.0
517
4364
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.0
294
2150
M54.5
ICD-10 Finland
Low back pain
1.7
8.9
239
1662
J01MA02
ATC
ciprofloxacin; systemic
1.7
8.8
253
1789
S01EC01
ATC
acetazolamide; systemic
4.0
8.8
25
65
H00.01
ICD-10 Finland
Abscess of the eyelid
50.6
8.7
10
*
ZXA00
NOMESCO Finland
Right side
1.7
8.7
180
1165
N02AX02
ATC
tramadol; systemic, rectal
1.6
8.6
282
2057
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.8
8.6
43
160
N02BE01
ATC
paracetamol; systemic, rectal
2.0
8.4
601
5348
A02BC05
ATC
esomeprazole; systemic
1.6
8.2
271
1975
H40.0
ICD-10 Finland
Glaucoma suspect
2.4
8.1
59
264
S29
ICPC
Skin symptom/complaint other
1.8
8.0
126
751
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.8
8.0
40
149
A02BC01
ATC
omeprazole; systemic
1.7
7.9
187
1250
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.5
7.9
27
80
R01AD12
ATC
fluticasone furoate; nasal
1.7
7.8
203
1391
WX402
NOMESCO Finland
General anaesthesia
1.8
7.8
133
811
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
4.1
7.7
21
53
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
7.7
51
219
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
7.6
236
1686
P01BA02
ATC
hydroxychloroquine; oral
2.2
7.6
64
304
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.6
79
408
H10.5
ICD-10 Finland
Blepharoconjunctivitis
4.3
7.5
19
45
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
7.5
454
3783
F73
ICPC
Eye infection/inflammation other
4.0
7.5
21
54
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
80.9
7.4
8
*
S01EE05
ATC
tafluprost; ophthalmic
3.1
7.4
30
99
3755A
ICD-9 Finland
Disorders of lachrymal system, Stenosis and insufficiency of lachrymal passages
+∞
7.3
7
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
7.3
7
*
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
+∞
7.3
7
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
7.3
64
310
J01CA04
ATC
amoxicillin; systemic
1.7
7.3
539
4699
M79.6
ICD-10 Finland
Pain in limb
1.6
7.2
278
2084
S01GX08
ATC
ketotifen; ophthalmic
2.7
7.2
37
140
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.3
7.2
26
80
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
30.4
7.2
9
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.7
7.1
39
152
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.1
7.0
66
328
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
7.0
51
228
H26.4
ICD-10 Finland
After-cataract
2.1
7.0
71
364
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.0
182
1244
H16.9
ICD-10 Finland
Keratitis, unspecified
5.9
7.0
18
31
L04AA06
ATC
mycophenolic acid; systemic
7.6
6.9
15
20
J02AC01
ATC
fluconazole; systemic
1.6
6.9
267
1999
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
6.9
64
317
F01
ICPC
Eye pain
3.2
6.8
26
83
B00.5
ICD-10 Finland
Herpesviral ocular disease
40.5
6.8
8
*
H16.8
ICD-10 Finland
Other keratitis
40.5
6.8
8
*
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.8
99
575
L04AB04
ATC
adalimumab; parenteral
4.0
6.7
19
49
H20.1
ICD-10 Finland
Chronic iridocyclitis
7.3
6.7
15
21
R03AC03
ATC
terbutaline; inhalant
1.9
6.7
94
538
E0000UV, ,
ATC
1.5
6.7
266
2001
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.5
6.7
16
25
L04AB01
ATC
etanercept; parenteral
6.0
6.6
17
29
R60.9
ICD-10 Finland
Oedema, unspecified
2.4
6.6
43
183
S18
ICPC
Laceration/cut
1.5
6.6
278
2116
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.9
6.6
19
50
ZXA10
NOMESCO Finland
Bilateral
1.7
6.6
122
761
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.0
6.5
29
101
S50.0
ICD-10 Finland
Contusion of elbow
3.1
6.5
26
85
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.7
6.5
20
55
S01EC03
ATC
dorzolamide; ophthalmic
5.8
6.5
17
30
J01FA06
ATC
roxithromycin; oral
1.5
6.5
258
1938
R52.9
ICD-10 Finland
Pain, unspecified
2.0
6.5
66
339
H02.8
ICD-10 Finland
Other specified disorders of eyelid
70.5
6.4
7
*
H04.9
ICD-10 Finland
Disorder of lacrimal system, unspecified
70.5
6.4
7
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
70.5
6.4
7
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
6.4
54
258
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.8
6.4
31
114
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.4
6.3
44
193
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
3.5
6.3
21
61
H02AB07
ATC
prednisone; oral
1.8
6.3
95
556
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.0
6.3
66
342
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.9
6.3
28
98
H04.6
ICD-10 Finland
Other changes in lacrimal passages
+∞
6.3
6
*
H03.1*B02.3
ICD-10 Finland
Zoster blepharitis
+∞
6.3
6
*
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
+∞
6.3
6
*
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
6.3
6
*
CBB00
NOMESCO Finland
Excision of chalazion
26.9
6.2
8
*
WX199
NOMESCO Finland
Other local analgesia
3.0
6.2
26
88
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.4
6.2
43
189
127
Kela drug reimbursment
Transplant complication
7.8
6.1
13
17
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.1
149
999
R60.0
ICD-10 Finland
Localized oedema
1.9
6.1
79
442
D07AC13
ATC
mometasone; topical
1.6
6.0
183
1291
H40.11
ICD-10 Finland
Low pressure glaucoma
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
399
3121
1.67
9.55
12.1
8.6
4.03
4.10
e9/l
0.31
354
2744
267
1892
1.67
9.32
3.9
3.0
—
—
—
0
0
348
2692
1.60
8.21
5.7
4.9
0.00
0.00
estimate
0.50
62
514
304
2280
1.60
8.16
6.6
4.3
35.52
35.50
g/l
0.02
284
2118
349
2721
1.58
7.83
4.3
3.7
0.00
0.01
estimate
0.80
64
503
333
2580
1.57
7.60
9.5
5.3
29.15
27.98
%
1.08
312
2416
387
3113
1.56
7.40
6.0
4.1
6.58
6.65
mmol/l
0.27
366
2886
342
2680
1.55
7.33
4.4
3.6
0.00
0.01
estimate
0.74
70
557
178
1196
1.66
7.32
2.3
1.7
1.47
1.15
mg/l
0.50
145
930
72
365
2.09
7.29
1.7
1.6
—
—
—
0
0
337
2644
1.54
7.10
8.8
6.1
1.22
1.22
mmol/l
0.08
287
2234
146
939
1.71
7.06
1.3
1.3
5.47
13.34
u/ml
1.58
57
380
325
2549
1.52
6.74
9.2
5.0
56.17
57.41
%
1.17
306
2384
219
1593
1.55
6.34
3.9
3.0
145.46
58.73
e6/l
0.38
172
1216
603
5496
1.82
6.06
19.6
13.0
18.43
22.98
mg/l
4.15
531
4331
468
4015
1.52
6.02
5.9
3.9
13.62
12.36
mm/h
1.18
447
3690
478
4126
1.53
5.91
9.8
6.9
78.44
78.40
u/l
0.01
452
3850
88
514
1.82
5.90
3.6
1.9
321.82
373.91
nmol/l
1.92
82
469
433
3668
1.49
5.81
5.5
4.4
3.11
2107.56
e6/l
—
9
61
302
2399
1.46
5.54
7.9
5.2
1.22
1.22
mmol/l
0.04
282
2181
290
2286
1.47
5.53
2.7
2.3
79.17
77.64
nmol/l
0.44
273
2037
45
212
2.20
5.51
2.4
2.4
37.79
40.57
u/l
0.36
39
189
129
857
1.62
5.41
3.5
2.6
0.78
1.21
e6/l
1.05
76
477
141
963
1.58
5.27
1.4
1.3
22.97
33.50
iu/ml
0.78
41
324
196
1442
1.50
5.22
4.0
2.9
0.24
0.37
e6/l
0.92
151
1090
257
2011
1.45
4.96
4.0
3.6
24.98
57.47
ng/l
1.12
164
1385
140
968
1.56
4.94
4.6
3.6
559.63
270.94
ng/l
0.59
99
735
155
1111
1.51
4.62
3.1
2.4
5.43
6.35
e6/l
0.34
140
1010
213
1629
1.45
4.58
3.4
2.4
68.16
58.66
u/l
0.48
200
1503
25
99
2.58
4.51
3.3
3.3
4.68
4.32
e9/l
0.33
25
99
623
5827
1.78
4.46
13.5
9.6
26.35
24.99
u/l
0.80
598
5609
175
1304
1.46
4.27
3.7
2.5
5721.34
6509.88
umol/l
0.09
160
1139
604
5617
1.64
4.24
21.4
15.0
3.96
3.96
mmol/l
0.02
584
5448
15
46
3.31
4.21
2.1
1.2
—
—
—
0
0
88
567
1.63
4.16
1.9
1.7
—
—
—
0
0
160
1180
1.46
4.11
4.4
4.1
1.02
1.02
kg/l
0.56
25
169
25
104
2.46
4.10
3.6
3.5
56.32
59.61
%
0.69
25
104
88
571
1.62
4.04
1.9
1.8
—
—
—
0
0
486
4340
1.41
4.04
4.8
4.1
14.87
14.80
pmol/l
0.27
452
3943
291
2395
1.37
3.98
19.2
13.7
1.23
1.23
inr
0.01
96
686
570
5250
1.51
3.97
4.8
4.4
5.83
5.89
mmol/l
0.65
524
4766
119
832
1.52
3.96
2.0
1.8
—
—
—
0
0
12
27
4.50
3.95
4.0
2.3
—
—
—
0
0
601
5602
1.60
3.94
21.2
14.9
139.56
139.63
mmol/l
0.25
584
5441
91
604
1.58
3.81
8.1
5.7
104.14
104.26
mmol/l
0.10
91
604
114
797
1.52
3.79
3.8
2.8
2.81
3.09
e6/l
0.10
62
419
71
453
1.63
3.50
3.8
3.4
1.23
1.23
mmol/l
0.17
66
381
115
819
1.49
3.50
4.2
3.1
0.82
0.82
mmol/l
0.00
110
767
302
2539
1.34
3.46
2.9
2.5
—
—
—
0
0
200
1581
1.37
3.41
2.3
2.0
139.38
229.85
u/l
1.33
191
1494
7
10
7.06
3.37
2.3
2.1
—
—
—
0
0
396
3472
1.33
3.36
3.3
3.1
—
—
—
0
0
29
142
2.09
3.31
1.7
1.2
8.40
2.00
u/ml
—
6
15
30
149
2.06
3.30
2.0
2.8
—
—
—
0
0
642
6130
1.77
3.26
28.2
19.4
39.45
39.86
%
0.78
608
5733
17
66
2.62
3.23
2.8
2.1
14.90
25.02
mg/l
—
10
20
642
6133
1.76
3.22
27.9
19.4
255.93
255.30
e9/l
0.08
627
5976
255
2109
1.33
3.20
4.5
3.8
—
—
—
0
0
173
1348
1.38
3.20
2.5
2.1
2.81
3.09
mg/l
1.12
160
1135
642
6137
1.75
3.15
27.9
19.4
4.43
4.45
e12/l
0.69
625
5965
29
145
2.04
3.15
1.7
1.2
3.67
8.83
u/ml
—
7
28
66
427
1.60
3.10
4.1
2.6
66.45
67.20
g/l
0.35
61
382
642
6141
1.74
3.09
28.1
19.5
133.50
133.69
g/l
0.13
633
6040
164
1275
1.38
3.07
2.6
2.2
—
—
—
0
0
523
4811
1.37
3.04
22.3
15.6
14.96
14.78
%
0.30
513
4723
56
354
1.63
2.89
2.3
2.4
21.67
25.19
au/ml
—
6
30
551
5125
1.39
2.88
15.9
12.1
80.36
81.03
ml/min/173m2
0.30
463
4200
150
1163
1.37
2.84
1.7
1.7
457.67
18266689.48
pmol/l
1.07
126
969
183
1466
1.34
2.80
4.8
4.0
0.00
0.00
estimate
0.80
64
510
10
28
3.61
2.79
2.0
3.5
97.90
97.57
%
—
10
28
130
990
1.39
2.74
3.6
2.8
2.45
2.46
mmol/l
0.49
114
861
6
10
6.04
2.70
1.0
1.0
—
—
—
0
0
132
1013
1.38
2.66
1.5
1.6
—
—
—
0
0
250
2110
1.29
2.60
2.1
2.0
96.66
95.93
pmol/l
0.09
129
1064
32
178
1.84
2.60
1.9
1.8
—
—
—
0
0
9
25
3.63
2.58
1.0
1.3
—
—
—
0
0
220
1831
1.30
2.53
4.0
3.3
2.35
2.36
mmol/l
0.12
193
1595
52
335
1.60
2.52
4.4
3.1
4.40
4.57
pmol/l
0.68
44
295
210
1740
1.30
2.50
4.0
3.1
30.03
31.31
u/l
0.40
194
1651
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
145
1.90
2.45
4.0
2.5
0.40
0.40
u/ml
0.00
17
86
70
486
1.49
2.44
7.6
3.2
1.92
2.01
mmol/l
0.10
61
394
77
551
1.45
2.31
8.2
6.3
0.89
1.40
mmol/l
0.50
62
437
547
5137
1.32
2.26
5.9
4.8
1.83
2.14
mu/l
0.71
512
4700
5
9
5.59
2.21
1.0
1.0
—
—
—
0
0
11
41
2.71
2.21
2.9
2.7
—
—
—
0
0
59
404
1.50
2.21
4.1
2.7
65.38
65.49
ml/min/173m2
0.01
26
175
15
67
2.27
2.19
1.1
1.1
—
—
—
0
0
315
2778
1.25
2.18
7.8
5.7
10.87
11.09
umol/l
0.14
307
2625
530
4964
1.30
2.18
6.1
5.4
39.47
39.58
mmol/mol
0.10
492
4597
28
159
1.79
2.17
1.6
1.4
318.11
308.97
ug/g
0.09
19
92
18
88
2.07
2.13
1.3
1.1
0.27
2.14
u/ml
—
9
45
47
310
1.55
2.09
4.1
2.9
126.47
126.51
g/l
0.00
47
304
29
169
1.75
2.07
2.0
1.5
0.21
0.23
g/l
0.53
29
162
45
296
1.56
2.03
1.4
1.7
—
—
—
0
0
25
140
1.82
2.03
1.3
1.4
—
—
—
0
0
62
439
1.45
1.99
2.2
2.4
6.18
6.19
ug/l
0.00
52
380
11
45
2.47
1.94
1.3
1.0
0.02
0.74
u/ml
—
5
12
21
113
1.89
1.93
1.2
1.2
—
2.10
—
0
11
29
174
1.70
1.89
2.0
1.5
1.12
1.18
g/l
0.73
29
167
27
159
1.73
1.88
1.3
1.1
—
—
—
0
0
280
2470
1.23
1.85
3.6
2.7
119.77
114.91
ug/l
0.12
267
2264
14
66
2.14
1.83
1.2
1.5
—
—
—
0
0
26
153
1.73
1.82
3.2
3.4
29.35
91.17
mg/l
0.81
19
120
39
256
1.56
1.80
1.2
1.3
26.49
27.86
iu/l
0.08
34
222
26
154
1.72
1.78
3.2
3.4
17.46
45.15
mg/l
0.78
19
121
6
18
3.35
1.75
1.3
1.4
—
—
—
0
0
90
696
1.34
1.75
2.7
2.3
23.39
22.20
%
0.28
79
582
8
30
2.69
1.73
1.0
1.2
—
—
—
0
0
16
82
1.97
1.70
2.2
1.4
119.00
110.36
u/ml
—
5
14
89
690
1.33
1.70
8.3
4.8
1.05
1.04
mmol/l
0.14
83
619
148
1229
1.26
1.69
1.4
1.3
1.10
1.59
u/ml
0.46
48
311
124
1012
1.28
1.63
1.8
1.7
1226.47
1208.82
nmol/l
0.08
99
747
37
248
1.52
1.58
11.1
3.0
23.49
24.12
mmol/l
0.89
37
242
26
160
1.65
1.58
1.3
1.1
—
—
—
0
0
37
249
1.51
1.56
4.2
2.2
1.20
1.20
%
0.01
37
249
96
769
1.29
1.47
3.5
4.2
24.46
21.52
%
0.81
39
356
82
643
1.31
1.47
8.1
7.0
—
—
—
0
0
32
212
1.53
1.46
2.2
1.8
1.46
1.18
ug/l
0.17
27
184
5
16
3.14
1.44
1.4
2.0
—
—
—
0
0
41
288
1.45
1.42
1.3
1.4
—
—
—
0
0
23
142
1.64
1.40
1.3
1.3
—
—
—
0
0
118
976
1.25
1.40
3.8
4.7
5.85
2.37
ug/l
0.66
107
868
24
150
1.62
1.39
1.4
1.2
—
—
—
0
0
28
182
1.56
1.39
2.8
1.8
—
—
—
0
0
147
1247
1.23
1.38
1.7
1.5
21.35
20.98
nmol/l
0.11
129
1045
5
17
2.95
1.36
3.8
6.3
—
—
—
0
0
567
5443
1.24
1.36
5.1
4.7
2.78
2.80
mmol/l
0.12
522
4999
17
98
1.75
1.32
1.5
1.2
—
—
—
0
0
5
18
2.79
1.28
1.0
1.5
—
—
—
0
0
17
99
1.74
1.28
1.2
1.3
—
—
—
0
0
17
99
1.74
1.28
1.2
1.3
—
—
—
0
0
22
138
1.61
1.27
2.3
1.6
—
—
—
0
0
23
146
1.60
1.27
1.2
1.1
—
—
—
0
0
16
92
1.76
1.26
1.9
2.4
16.30
16.34
%
—
6
47
182
1594
1.19
1.23
3.2
3.1
7.08
7.22
mmol/l
0.15
154
1354
12
63
1.92
1.23
1.0
1.0
—
—
—
0
0
171
1490
1.20
1.23
3.6
3.0
1466.16
1426.35
ng/l
0.05
151
1248
16
93
1.74
1.22
1.6
1.2
354.62
210.66
u/ml
—
9
51
8
37
2.18
1.21
1.3
1.2
—
—
—
0
0
70
553
1.30
1.21
2.6
2.8
0.78
0.75
ug/l
0.11
43
340
159
1382
1.20
1.17
1.8
1.6
1.35
1.37
mmol/l
0.17
133
1158
5
20
2.51
1.15
1.2
1.1
—
—
—
0
0
42
312
1.37
1.11
1.5
1.5
—
—
—
0
0
59
462
1.30
1.10
3.5
2.1
34.96
33.51
u/l
0.12
52
385
11
59
1.88
1.08
2.0
1.6
33.18
32.29
pg
0.32
11
59
69
554
1.27
1.07
3.3
3.3
—
—
—
0
0
5
22
2.28
1.03
1.6
3.0
282.40
914.73
u/ml
—
5
22
552
5331
1.18
0.98
4.7
4.2
4.74
4.73
mmol/l
0.10
510
4936
0
30
0.00
0.97
0.0
1.0
—
35.42
—
0
15
0
30
0.00
0.97
0.0
1.0
—
559.71
—
0
17
16
100
1.61
0.97
1.2
1.6
—
—
—
0
0
7
36
1.95
0.97
1.1
1.5
—
480.00
—
0
6
18
117
1.55
0.94
1.3
1.3
—
—
—
0
0
6
28
2.15
0.91
1.0
1.3
—
—
—
0
0
23
161
1.44
0.87
1.2
1.2
—
—
—
0
0
8
43
1.87
0.87
1.0
1.0
—
—
—
0
0
173
1553
1.15
0.86
4.0
3.8
9.30
9.69
mg/mmol
0.04
100
969
547
5303
1.16
0.80
4.6
4.2
1.51
1.51
mmol/l
0.02
504
4883
6
33
1.83
0.79
2.0
1.4
—
—
—
0
0
16
107
1.51
0.76
1.3
1.3
—
—
—
0
0
13
83
1.58
0.75
1.0
1.0
3.27
1.73
u/ml
—
6
33
13
84
1.56
0.72
1.2
1.1
—
—
—
0
0
5
26
1.93
0.70
1.0
1.2
—
—
—
0
0
114
1011
1.15
0.68
1.5
1.4
—
—
—
0
0
11
70
1.58
0.65
1.4
1.3
—
—
—
0
0
11
70
1.58
0.65
1.4
1.3
—
—
—
0
0
11
70
1.58
0.65
1.4
1.3
—
—
—
0
0
5
29
1.73
0.64
4.6
1.6
—
—
—
0
0
5
29
1.73
0.64
2.2
1.5
—
—
—
0
0
5
29
1.73
0.64
4.6
1.6
—
—
—
0
0
35
279
1.27
0.63
1.6
1.9
—
—
—
0
0
11
71
1.56
0.62
1.4
1.3
—
—
—
0
0
11
71
1.56
0.62
1.4
1.3
—
—
—
0
0
11
71
1.56
0.62
1.4
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
2.0
—
—
—
0
0
15
106
1.42
0.58
2.0
1.9
128.50
129.55
g/l
—
8
79
6
35
1.72
0.58
1.0
1.3
—
—
—
0
0
14
98
1.44
0.57
5.1
2.8
40.71
37.15
umol/l
0.16
14
84
69
599
1.17
0.56
4.5
2.6
6.99
8.53
umol/l
0.40
56
495
42
348
1.22
0.56
1.8
1.9
—
—
—
0
0
10
65
1.55
0.55
1.0
1.2
—
—
—
0
0
6
37
1.63
0.55
1.5
1.3
0.93
1.07
g/l
—
6
37
39
322
1.22
0.54
5.1
3.7
1.71
1.86
mmol/l
0.13
29
245
27
214
1.27
0.53
2.4
1.9
—
—
—
0
0
22
170
1.30
0.52
1.8
1.5
—
—
—
0
0
6
40
1.50
0.51
1.5
1.1
448.33
219.34
mg/l
—
6
35
9
65
1.39
0.50
1.3
1.3
—
0.68
nmol/l
—
0
5
525
5127
1.10
0.49
4.2
3.8
1.31
1.27
mmol/l
0.73
480
4694
18
137
1.32
0.47
2.1
1.6
—
—
—
0
0
7
49
1.43
0.46
2.1
2.4
—
—
—
0
0
50
432
1.17
0.45
4.8
3.5
116.58
80.13
ng/l
1.49
45
382
25
202
1.25
0.44
1.5
2.1
1394.33
4026.97
u/l
—
9
77
5
31
1.62
0.43
1.4
1.2
2.89
2.03
mmol/l
—
5
31
8
56
1.43
0.42
1.9
1.7
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
8
57
1.41
0.42
1.9
2.4
13.06
13.04
%
—
8
57
8
58
1.38
0.41
2.0
1.4
—
—
—
0
0
8
58
1.38
0.41
2.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
8.36
—
0
8
5
35
1.43
0.39
1.0
1.3
—
—
—
0
0
9
67
1.35
0.38
1.2
1.1
—
—
—
0
0
5
37
1.35
0.37
1.2
2.0
—
—
—
0
0
369
3576
1.07
0.37
3.9
2.9
51.31
45.15
u/l
0.37
345
3331
24
198
1.22
0.36
2.3
1.7
—
—
—
0
0
15
190
0.78
0.36
1.3
1.5
—
—
—
0
0
20
162
1.24
0.36
1.1
1.5
—
—
—
0
0
6
42
1.43
0.35
1.0
1.1
—
—
—
0
0
6
42
1.43
0.35
1.0
1.2
—
—
—
0
0
6
42
1.43
0.35
1.0
1.1
—
—
—
0
0
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
7
52
1.35
0.31
1.1
1.1
107.00
93.38
%
—
7
47
19
156
1.22
0.31
1.2
1.4
—
—
—
0
0
19
156
1.22
0.31
1.2
1.4
—
—
—
0
0
7
53
1.32
0.31
1.3
1.2
—
—
—
0
0
17
138
1.24
0.30
1.7
1.7
—
—
—
0
0
7
55
1.28
0.30
2.9
3.4
—
—
—
0
0
8
108
0.74
0.29
1.6
1.7
—
—
—
0
0
8
64
1.25
0.27
1.0
1.1
—
—
—
0
0
11
87
1.27
0.24
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
2.6
1.3
—
—
—
0
0
10
79
1.27
0.22
1.3
1.8
—
—
—
0
0
5
42
1.19
0.21
1.2
1.8
5.94
8.02
mmol/l
—
5
42
23
201
1.15
0.21
1.4
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
67
626
1.08
0.20
1.8
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
6
50
1.20
0.19
2.2
1.7
—
—
—
0
0
18
156
1.16
0.18
1.2
1.4
—
—
—
0
0
18
156
1.16
0.18
1.2
1.4
—
—
—
0
0
6
53
1.13
0.18
1.0
1.3
—
—
—
0
0
20
175
1.15
0.18
1.3
1.4
266.89
256.80
miu/ml
—
9
87
7
62
1.13
0.17
1.6
2.7
13.00
52.86
u/ml
—
7
62
11
130
0.84
0.16
3.0
1.3
548.18
489.66
mg/l
0.15
11
124
8
72
1.11
0.16
1.9
1.4
—
—
—
0
0
10
119
0.84
0.15
3.1
1.2
4.13
3.70
mmol/l
—
10
112
14
122
1.15
0.14
1.9
1.5
—
—
—
0
0
11
95
1.16
0.11
4.3
3.7
877.85
2957.94
u/ml
0.35
11
89
60
573
1.05
0.11
1.7
2.0
—
—
—
0
0
46
483
0.95
0.10
1.7
1.6
—
—
—
0
0
10
87
1.15
0.09
1.4
1.3
—
—
—
0
0
18
196
0.92
0.09
4.5
3.0
44.94
938.72
u/ml
0.68
18
166
6
56
1.07
0.08
2.5
1.4
—
—
—
0
0
28
263
1.07
0.08
1.1
1.0
—
—
—
0
0
6
71
0.84
0.07
1.5
1.6
—
—
—
0
0
8
74
1.08
0.07
2.1
2.5
105.37
105.72
mmol/l
—
8
74
9
86
1.05
0.07
1.9
1.6
—
—
—
0
0
9
86
1.05
0.07
1.9
1.6
—
—
—
0
0
8
91
0.88
0.07
1.1
1.6
—
—
—
0
0
19
202
0.94
0.05
2.3
1.9
—
—
—
0
0
15
140
1.07
0.04
1.4
1.2
—
—
—
0
0
57
556
1.03
0.04
4.1
4.0
12.89
28.08
ug/l
0.44
47
459
22
210
1.05
0.03
1.2
1.4
—
—
—
0
0
15
142
1.06
0.02
2.0
1.6
3.14
5.88
iu/l
—
5
45
63
640
0.98
0.02
4.9
4.4
32.98
32.67
%
0.09
43
421
43
423
1.02
0.01
1.1
1.2
201.47
145.57
iu/ml
0.36
13
159
12
126
0.95
0.00
1.8
1.5
—
—
—
0
0
27
273
0.99
0.00
1.2
1.5
—
—
—
0
0
12
122
0.98
0.00
1.3
1.6
—
—
—
0
0
13
128
1.02
0.00
2.1
2.1
248.80
103.96
ug/min
—
6
71
61
606
1.01
0.00
2.0
1.7
1.41
1.42
%
0.02
55
539
0
5
0.00
0.00
0.0
1.2
—
8.04
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
64
0.94
0.00
1.2
1.5
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
79
1.01
-0.00
2.3
1.8
164.50
224.28
pmol/l
—
8
72
0
9
0.00
-0.00
0.0
2.1
—
0.56
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
58.68
—
0
6
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.5
—
—
—
0
0
7
71
0.99
-0.00
1.1
1.4
7.44
7.46
mmol/l
—
7
61
8
79
1.01
-0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
13.73
—
0
6
8
88
0.91
-0.00
2.1
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRIMINFLAMACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMACU | 1.139 [1.0, 1.3] | 0.053 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 749 out of 3226 females with H7_LACRIMINFLAMACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMACU | 1.276 [1.02, 1.59] | 0.031 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1257 males with H7_LACRIMINFLAMACU died.
Mortality risk
Mortality risk for people of age
years, who have H7_LACRIMINFLAMACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.272% |
| 5 | 0.591% | 1.552% |
| 10 | 1.593% | 3.938% |
| 15 | 2.97% | 7.327% |
| 20 | 5.483% | 12.006% |
Relationships between endpoints
↥Index endpoint: H7_LACRIMINFLAMACU – Inflammation of lacrimal passages (acute and unspecified)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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