No definition available.
Inflammation of lacrimal passages (acute and unspecified)
DOID EFO Endpoint Browser PheWeb
H7_LACRIMINFLAMACU
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
640 |
4. Check minimum number of eventsNone |
640 |
5. Include endpointsNone |
640 |
6. Filter based on genotype QC (FinnGen only) |
640 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Inflammatio viarum lacrimalium acuta sive non specificata
Similar endpoints
↥List of similar endpoints to
Inflammation of lacrimal passages (acute and unspecified)
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5708 | 4089 | 1592 |
| Only index persons | 4945 | 3555 | 1390 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.04 |
| Only index persons | 0.11 | 0.13 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 58.12 | 62.11 | 48.00 |
| Only index persons | 56.05 | 59.83 | 46.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 640 | 477 | 163 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.07 |
| Median age at first event (years) | 56.94 | 56.08 | 59.46 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 563
- Matched controls
- 5628
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
16384.0
323.0
537
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
1263.2
252.7
228
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
1061.9
166.7
155
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
1080.6
95.9
91
*
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
80.1
75
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.7
63.9
332
1321
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
680.1
63.1
61
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
667.6
62.0
60
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
50.8
48
*
H04.10
ICD-10 Finland
Dry eye syndrome
9.0
41.9
93
121
H04.0
ICD-10 Finland
Dacryoadenitis
209.0
38.3
39
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.1
32.3
83
134
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
26.8
288
1586
H04.2
ICD-10 Finland
Epiphora
261.1
24.9
25
*
J01DB01
ATC
cefalexin; oral
3.1
22.3
488
3818
H02.3
ICD-10 Finland
Blepharochalasis
54.4
22.3
26
5
H01.0
ICD-10 Finland
Blepharitis
7.4
21.0
51
75
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
5.2
19.3
62
131
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
18.9
18
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
18.4
121
473
F03
ICPC
Eye discharge
4.8
18.2
62
140
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.7
17.2
60
139
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
16.7
16
*
36803
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryocystitis acuta, phlegmonosa
+∞
16.7
16
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
5.2
16.3
51
105
S01AX11
ATC
[U] ofloxacin; ophthalmic
5.4
14.9
45
89
CCA30
NOMESCO Finland
Incision of lacrimal sac
+∞
13.6
13
*
F29
ICPC
Eye symptom/complaint other
3.5
13.5
64
197
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
51.2
12.9
15
*
UDM02
NOMESCO Finland
Sinoscopy
7.6
12.6
29
40
J01FF01
ATC
clindamycin; systemic
2.1
12.3
167
939
H02.4
ICD-10 Finland
Ptosis of eyelid
27.4
12.1
16
6
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.3
11.7
35
69
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
122.4
11.5
12
*
S01ED51
ATC
timolol, combinations; ophthalmic
3.2
10.9
57
190
114
Kela drug reimbursment
Glaucoma
2.8
10.5
68
259
CCC50
NOMESCO Finland
Dacryocystectomy
+∞
10.4
10
*
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
10.4
10
*
3753A
ICD-9 Finland
Disorders of lachrymal system, Acute and unspecified inflammation of lachrymal passages
+∞
10.4
10
*
R01AD09
ATC
mometasone; nasal
1.8
10.1
253
1754
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
10.0
101
492
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
9.8
74
309
J01DA01
ATC
[U] cefalexin; systemic
1.8
9.8
358
2786
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
9.5
244
1695
CC1CB
NOMESCO Finland
Dacryocystography
+∞
9.4
9
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
9.4
9
*
J01FA10
ATC
azithromycin; systemic
1.7
9.4
324
2463
S01EE01
ATC
latanoprost; ophthalmic
3.2
9.3
48
158
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.4
9.2
82
377
H16.0
ICD-10 Finland
Corneal ulcer
4.4
9.1
32
76
A02BC05
ATC
esomeprazole; systemic
1.7
8.7
228
1578
H02AB06
ATC
prednisolone; systemic
1.7
8.6
257
1853
H57.1
ICD-10 Finland
Ocular pain
4.5
8.5
29
67
ZXA00
NOMESCO Finland
Right side
1.8
8.4
156
968
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
8.4
130
754
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
+∞
8.4
8
*
A02BC02
ATC
pantoprazole; systemic
1.7
8.3
356
2834
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.2
8.3
43
143
WX002
NOMESCO Finland
Sedation and analgesia
2.0
8.3
114
631
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
5.5
8.2
23
43
H10
ICD-10 Finland
Conjunctivitis
2.9
8.2
48
174
S01EC01
ATC
acetazolamide; systemic
5.5
7.9
22
41
S01ED01
ATC
timolol; ophthalmic
3.6
7.7
34
100
R06AE07
ATC
cetirizine; oral
1.7
7.7
246
1785
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.6
280
2114
WX110
NOMESCO Finland
Local anesthesy
1.7
7.5
363
2948
H10.5
ICD-10 Finland
Blepharoconjunctivitis
7.8
7.4
16
21
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.4
201
1390
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
7.3
198
1370
3755A
ICD-9 Finland
Disorders of lachrymal system, Stenosis and insufficiency of lachrymal passages
+∞
7.3
7
*
R51.80
ICD-10 Finland
Headache
2.1
7.2
90
478
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
3.3
7.2
34
106
ZXA05
NOMESCO Finland
Left side
1.8
7.2
145
917
H02AB04
ATC
methylprednisolone; systemic
2.0
6.8
87
465
F73
ICPC
Eye infection/inflammation other
6.2
6.8
17
28
S01GX01
ATC
cromoglicic acid; ophthalmic
1.8
6.8
115
687
S01XA18
ATC
ciclosporin; ophthalmic
16.9
6.8
10
6
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
22.8
6.7
9
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
7.9
6.6
14
18
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.6
209
1497
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
6.6
71
355
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.5
474
4211
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
70.6
6.4
7
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
70.6
6.4
7
*
F01
ICPC
Eye pain
4.4
6.3
21
49
S01GX08
ATC
ketotifen; ophthalmic
3.7
6.3
25
69
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
3.7
6.3
25
69
H04
ICD-10 Finland
Disorders of lacrimal system
+∞
6.3
6
*
H04.9
ICD-10 Finland
Disorder of lacrimal system, unspecified
+∞
6.3
6
*
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
+∞
6.3
6
*
H00.01
ICD-10 Finland
Abscess of the eyelid
+∞
6.3
6
*
ZXD20
NOMESCO Finland
Day surgery
2.1
6.2
71
367
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.9
6.1
35
125
S01EX03
ATC
NA
3.8
6.1
24
66
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
6.0
52
236
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.0
219
1616
WX199
NOMESCO Finland
Other local analgesia
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRIMINFLAMACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMACU | 1.139 [1.0, 1.3] | 0.053 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 749 out of 3226 females with H7_LACRIMINFLAMACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMACU | 1.276 [1.02, 1.59] | 0.031 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1257 males with H7_LACRIMINFLAMACU died.
Mortality risk
Mortality risk for people of age
years, who have H7_LACRIMINFLAMACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.272% |
| 5 | 0.591% | 1.552% |
| 10 | 1.593% | 3.938% |
| 15 | 2.97% | 7.327% |
| 20 | 5.483% | 12.006% |
Relationships between endpoints
↥Index endpoint: H7_LACRIMINFLAMACU – Inflammation of lacrimal passages (acute and unspecified)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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