No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
1338 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
998 |
4. Check minimum number of eventsNone |
998 |
5. Include endpointsNone |
998 |
6. Filter based on genotype QC (FinnGen only) |
998 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Mandibular retrognathia AND surgery (BSSRO)
based on the number of shared cases.
Similar with more cases:
- Bilateral sagittal split ramus osteotomy operation
- LeFortI or BSSRO operation
- Mandibular retrognathia
- Dentofacial anomalies [including malocclusion]
- Diseases of oral cavity, salivary glands and jaws
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6120 | 4159 | 1944 |
| Only index persons | 6048 | 4126 | 1922 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.05 |
| Only index persons | 0.13 | 0.15 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 35.50 | 35.14 | 36.32 |
| Only index persons | 35.57 | 35.18 | 36.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 998 | 736 | 262 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.12 |
| Median age at first event (years) | 37.80 | 36.70 | 40.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 903
- Matched controls
- 9030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
192.6
323.0
485
54
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
229.0
323.0
557
63
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
150.9
323.0
430
54
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
73.7
323.0
485
140
K07.23
ICD-10 Finland
Deep bite
95.3
323.0
369
65
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
186.3
323.0
519
65
K07.13
ICD-10 Finland
Retrognaty, mandibular
+∞
323.0
903
31
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
146.0
323.0
450
61
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
289.6
323.0
444
30
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
90.9
323.0
456
100
SBB10
NOMESCO Finland
Teeth copy
64.8
323.0
616
289
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
166.1
323.0
329
31
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
+∞
323.0
903
12
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
109.5
319.7
338
49
EB1MA
NOMESCO Finland
Cephalometry with X-ray
76.3
303.0
338
70
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
126.0
290.8
303
36
SAA04
NOMESCO Finland
Special inverstigation of mouth
24.8
256.6
383
260
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
91.9
253.8
276
43
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
24.9
208.0
305
181
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
102.8
203.6
219
28
SJC00
NOMESCO Finland
Bracket with fixed attachment
159.1
193.4
199
16
SJB60
NOMESCO Finland
External device grinding and adaptation
77.9
175.2
196
32
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
66.0
175.1
201
39
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
92.2
173.8
190
26
SXC05
NOMESCO Finland
Other oral or dental procedure
16.9
173.0
294
251
EEC05
NOMESCO Finland
Le Fort I osteotomy
160.7
164.8
170
13
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
96.7
159.1
173
22
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
8.7
154.2
398
752
K07.24
ICD-10 Finland
Open bite
59.6
148.8
174
36
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
45.6
136.5
168
45
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
89.5
136.4
150
20
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
382.6
132.3
130
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
15.6
128.5
222
185
K07.10
ICD-10 Finland
Asymmetry of jaw
134.1
120.6
127
11
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
118.5
115.3
123
12
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
31.1
110.7
149
57
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
8.5
109.6
267
424
SAA03
NOMESCO Finland
Extended examination of mouth
4.8
106.3
612
2733
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
108.6
105.8
114
12
K07.60
ICD-10 Finland
Snapping jaw
9.3
104.6
237
331
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
13.9
101.6
183
162
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
9.9
99.8
217
280
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
97.9
95.3
104
12
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
81.8
91.5
102
14
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
106.0
87.9
95
10
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
60.3
87.4
102
19
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
65.9
86.9
100
17
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.1
84.8
479
1935
EBB10
NOMESCO Finland
Insertion of dental implant
28.2
84.2
116
47
K07.14
ICD-10 Finland
Retrognaty, maxillary
72.9
75.9
86
13
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
163.3
72.2
75
5
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
41.6
64.1
80
21
EBA10
NOMESCO Finland
Surgical removal of tooth
4.3
60.5
265
793
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
66.7
59.3
68
11
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
24.9
57.8
82
36
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
110.8
57.6
62
6
EBB15
NOMESCO Finland
Insertion of dental implant abutment
38.4
56.0
71
20
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
126.1
55.5
59
5
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
29.1
55.3
75
28
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
281.7
52.7
53
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.0
52.4
501
2667
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
75.8
50.7
57
8
K01.0
ICD-10 Finland
Embedded teeth
12.9
47.0
85
72
EDC30
NOMESCO Finland
Genioplasty
481.5
46.7
46
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.2
44.1
148
327
J01CE02
ATC
phenoxymethylpenicillin; oral
3.2
42.1
755
5577
SJA02
NOMESCO Finland
Plan for orthodontic care
79.0
40.3
45
6
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
21.7
40.1
59
29
SXC03
NOMESCO Finland
Other oral or dental procedure
19.4
39.3
60
33
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
12.4
35.6
65
56
K00.00
ICD-10 Finland
Hypodontia
20.7
34.3
51
26
SAA02
NOMESCO Finland
Basic examination of mouth
2.6
33.9
700
5157
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
10.9
33.4
65
64
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
49.5
31.8
38
8
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
85.6
29.9
33
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
7.1
28.9
73
111
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
11.9
28.7
53
47
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
28.3
28.2
38
14
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
25.4
28.1
39
16
ZXA10
NOMESCO Finland
Bilateral
2.9
26.9
188
751
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
14.3
26.5
45
33
OIKK
NOMESCO Finland
NA
10.1
26.0
52
54
EB1WA
NOMESCO Finland
NA
27.1
25.0
34
13
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.8
24.8
175
704
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
10.7
23.8
46
45
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
20.2
23.6
35
18
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
22.0
23.6
34
16
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
10.5
23.0
45
45
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
36.0
22.2
28
8
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
8.1
22.0
50
65
EFB50
NOMESCO Finland
Orthodontic procedure connected with ortognathic surgery
225.2
21.7
22
*
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
44.5
21.5
26
6
SPB10
NOMESCO Finland
Production of temporary crone to tooth
15.1
21.3
35
24
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.2
21.1
83
212
EEC02
NOMESCO Finland
Rapid expansion of maxilla
+∞
20.9
20
*
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
7.9
20.9
48
64
SDA02
NOMESCO Finland
Parodonthologic therapy
2.0
19.4
348
2164
EBA12
NOMESCO Finland
Complicated surgical removal of tooth
4.6
19.0
67
154
SAA01
NOMESCO Finland
Simple examination of mouth
2.0
18.7
704
5724
K07.9
ICD-10 Finland
Dentofacial anomaly, unspecified
193.8
18.6
19
*
SPAT1324
SPAT
Screening procedure
2.1
18.1
266
1518
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
17.7
255
1445
EDW99
NOMESCO Finland
Other operation on mandible
51.0
17.0
20
*
SPB20
NOMESCO Finland
Temporary bridge between two or more teeth
17.8
17.0
26
15
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.7
17.0
58
129
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
12.4
16.9
30
25
EBA00
NOMESCO Finland
Extraction of tooth
1.9
16.6
318
2000
K01.17
ICD-10 Finland
Retained molar with obstruction in the lower jaw
5.4
16.6
50
97
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
17.1
16.1
25
15
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.9
15.6
272
1644
EG1CG
NOMESCO Finland
Extensive MRI examination of mandipular joint with high intensity magnet
26.8
15.6
21
8
R06.5
ICD-10 Finland
Mouth breathing
2.8
15.3
104
403
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.6
14.8
69
205
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
14.5
14.6
24
17
J01FF01
ATC
clindamycin; systemic
1.9
13.0
247
1526
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
2.4
12.9
117
532
K07.4
ICD-10 Finland
Malocclusion, unspecified
5.8
12.6
35
62
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
32.5
12.6
16
5
SJD60
NOMESCO Finland
NA
+∞
12.5
12
*
K07.62
ICD-10 Finland
Habitual dislocation of the jaw joint
9.4
12.0
24
26
EGA00
NOMESCO Finland
Arthroscopy of mandibular joint
47.3
11.9
14
*
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
30.5
11.7
15
5
WX704
NOMESCO Finland
Intubation
2.8
11.6
79
304
K07.00
ICD-10 Finland
Macrognatia (hyperplasia) of the upper jaw
65.8
11.6
13
*
N02BE01
ATC
paracetamol; systemic, rectal
1.8
11.4
739
6444
WX720
NOMESCO Finland
Own respiration
4.1
11.3
43
108
EBA40
NOMESCO Finland
Excision of apex of root of tooth
7.4
11.3
26
36
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
35.5
11.3
14
*
K07.0
ICD-10 Finland
Major anomalies of jaw size
35.5
11.3
14
*
SPC08
NOMESCO Finland
Implant crown
20.3
11.2
16
8
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
60.7
10.6
12
*
K07.09
ICD-10 Finland
Anomaly in the size of the jaws UNS
+∞
10.4
10
*
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.7
10.4
258
1712
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.6
10.4
345
2486
G47.3
ICD-10 Finland
Sleep apnoea
1.8
10.0
177
1054
SPC25
NOMESCO Finland
Other demanding attachment of crone of tooth
16.9
9.9
15
9
SXB10
NOMESCO Finland
Removal of attachments and rails from moth
26.3
9.8
13
5
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
9.8
307
2168
EMAK
NOMESCO Finland
NA
3.1
9.8
52
173
SPA41
NOMESCO Finland
Precision impression for fixed dental prosthesis
5.8
9.6
26
46
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
9.5
286
1998
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
101.0
9.4
10
*
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
2.2
9.0
87
409
N03AX16
ATC
pregabalin; oral
1.7
8.9
185
1159
SPAT1263
SPAT
Sampling
1.6
8.8
352
2625
HAMTE
NOMESCO Finland
NA
9.6
8.8
17
18
XX3DW
NOMESCO Finland
Time consuming IT work
2.2
8.3
82
386
K07.05
ICD-10 Finland
Micrognatia (hypoplasia) of both jaws
+∞
8.3
8
*
ECB05
NOMESCO Finland
Mucogingival repair
10.9
8.3
15
14
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
33.7
8.1
10
*
Z50.1
ICD-10 Finland
Other physical therapy
2.9
8.1
47
167
K07.61
ICD-10 Finland
Cracking jaw joint
3.5
8.0
35
102
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
7.9
392
3048
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
7.8
833
7754
WX725
NOMESCO Finland
Noninvasive ventilation
2.8
7.7
46
167
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
7.6
60
256
G50.8
ICD-10 Finland
Other disorders of trigeminal nerve
12.0
7.6
13
11
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
4.0
7.5
28
71
EEW99
NOMESCO Finland
Other operation on maxilla
+∞
7.3
7
*
K07.2
ICD-10 Finland
Anomalies of dental arch relationship
+∞
7.3
7
*
EB1AD
NOMESCO Finland
Cone beam CT of teeth and jaws (one quarter)
9.5
7.3
14
15
EEC00
NOMESCO Finland
Segmental osteotomy of maxilla
30.3
7.2
9
*
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
30.3
7.2
9
*
TEG00
NOMESCO Finland
Punction of mandibular joint
20.2
7.1
10
5
SCD01
NOMESCO Finland
Simple removal of tooth plaque or tartar
5.9
6.9
18
31
K07.68
ICD-10 Finland
Other disorders of the jaw joint
7.6
6.9
15
20
K07.33
ICD-10 Finland
Crowding of tooth or teeth
22.7
6.7
9
*
K06.00
ICD-10 Finland
Local gingivore traction
3.8
6.6
26
70
EG1AA
NOMESCO Finland
Mandibular joint X-ray examination
6.9
6.5
15
22
SPA02
NOMESCO Finland
Preparation for dental prosthetics
4.0
6.5
24
61
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.4
309
2360
EB1TW
NOMESCO Finland
3D modelling of dentition
70.3
6.4
7
*
ECA70
NOMESCO Finland
Regenerative parodontal operation or gingiva and alveolus transplantation
11.1
6.3
11
10
ECU00
NOMESCO Finland
Removal of implant or external fixation device from alveoli
18.2
6.3
9
5
EB1S1
NOMESCO Finland
Photography of teeth
26.9
6.2
8
*
EDC45
NOMESCO Finland
Reconstruction of mandible using bone graft
26.9
6.2
8
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
7.1
6.2
14
20
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.5
6.2
226
1624
ECA55
NOMESCO Finland
Complicated parodontal operation
10.1
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
434
3214
1.62
12.16
2.9
3.0
—
—
—
0
0
480
3825
1.49
8.69
3.9
3.9
—
—
—
0
0
499
4071
1.45
7.65
2.9
3.0
0.0
0.0
estimate
0.50
105
756
498
4125
1.41
6.68
3.0
3.0
0.0
0.0
estimate
0.80
102
746
494
4087
1.41
6.67
4.1
4.2
0.0
0.0
estimate
0.40
106
775
27
105
2.62
5.00
2.4
2.4
1.5
1.4
mmol/l
0.57
27
100
33
700
0.45
4.98
3.0
2.4
34.1
114.1
u/l
0.60
28
586
270
2127
1.37
4.47
3.0
3.3
0.0
0.0
estimate
1.28
106
765
667
6014
1.33
4.24
4.0
3.7
8.0
9.7
mm/h
4.66
636
5668
16
55
2.94
3.75
1.5
2.4
3.9
4.0
mmol/l
0.41
16
55
16
55
2.94
3.75
1.5
2.4
105.4
105.5
mmol/l
0.02
16
55
70
444
1.62
3.46
1.4
1.5
—
—
—
0
0
178
1374
1.36
3.28
1.4
1.6
62893539.1
39868629.9
pmol/l
0.20
159
1214
834
7873
1.36
3.23
4.7
4.7
1.7
2.1
mu/l
0.90
802
7447
69
1025
0.65
3.05
2.3
2.4
2.7
3.5
e6/l
0.50
45
515
53
816
0.63
2.77
2.7
5.8
1.0
1.0
mmol/l
1.06
47
768
56
833
0.65
2.51
2.7
3.6
29.6
31.4
%
0.81
44
617
872
8368
1.33
2.38
8.4
11.1
3.9
3.9
mmol/l
0.39
856
8152
67
467
1.47
2.25
1.3
1.3
229.1
224.4
miu/ml
0.04
37
237
42
267
1.60
2.15
1.6
1.7
35.8
39.3
nmol/l
0.47
42
262
241
2043
1.24
2.14
1.5
1.5
—
—
—
0
0
82
1101
0.72
2.14
2.2
2.3
1.6
0.9
e6/l
0.49
59
590
75
544
1.41
2.06
1.6
1.6
302.2
309.4
mu/l
0.05
68
485
210
1761
1.24
2.06
3.0
3.2
1.0
1.0
kg/l
0.03
29
223
18
91
2.00
1.96
1.7
1.3
—
—
—
0
0
51
349
1.49
1.91
1.9
1.7
—
—
—
0
0
718
6789
1.21
1.91
4.4
4.1
14.4
14.4
pmol/l
0.06
688
6374
44
292
1.53
1.90
1.0
1.1
3.4
3.5
u/ml
—
6
47
25
143
1.77
1.90
2.2
3.3
18.2
24.1
mg/l
0.52
16
88
153
1849
0.80
1.85
2.2
2.6
0.1
0.4
e6/l
5.77
123
1349
636
5958
1.19
1.84
5.5
7.0
70.9
75.0
u/l
3.36
616
5644
864
8342
1.27
1.78
8.4
11.1
139.9
139.7
mmol/l
3.33
847
8143
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
46
0.00
1.71
0.0
1.1
—
—
—
0
0
273
2402
1.19
1.63
2.2
2.5
54.6
55.3
u/l
0.14
257
2253
14
262
0.53
1.61
2.1
3.2
24.2
24.2
mmol/l
—
9
239
36
240
1.52
1.56
2.0
1.8
—
—
—
0
0
66
869
0.74
1.56
2.2
2.7
4.5
6.9
umol/l
2.71
57
741
261
2926
0.85
1.41
3.1
5.7
1.2
1.2
mmol/l
0.65
235
2683
38
263
1.46
1.41
2.2
1.9
—
—
—
0
0
25
384
0.64
1.39
1.4
1.5
—
—
—
0
0
20
119
1.69
1.38
1.4
1.7
7.2
7.6
mmol/l
0.34
14
69
87
1083
0.78
1.37
2.2
3.4
0.8
0.8
mmol/l
0.57
78
1030
40
558
0.71
1.37
3.6
4.3
39.6
25.1
ug/l
0.20
30
433
37
257
1.46
1.35
2.2
3.3
25.6
25.4
mmol/l
0.18
37
249
0
38
0.00
1.34
0.0
1.1
—
—
—
0
0
448
4151
1.14
1.32
2.6
2.7
70.7
90.7
ug/l
4.00
433
3935
79
625
1.29
1.31
2.4
2.2
6475.0
4330.3
u/l
0.27
36
261
5
18
2.79
1.28
2.2
3.8
—
—
—
0
0
5
18
2.79
1.28
2.2
3.8
—
—
—
0
0
248
2212
1.16
1.24
1.7
1.6
—
—
—
0
0
65
505
1.31
1.24
3.0
3.1
1.2
1.2
mmol/l
0.09
60
438
184
2099
0.85
1.23
1.8
1.7
1.4
1.4
mmol/l
0.62
161
1821
34
476
0.70
1.21
2.3
3.8
68.1
76.9
ng/l
0.50
29
436
35
248
1.43
1.18
1.1
1.1
0.5
1.8
u/ml
1.34
13
95
6
127
0.47
1.17
2.8
1.6
—
—
—
0
0
920
9018
1.26
1.16
8.5
8.9
26.5
26.9
u/l
0.26
902
8803
7
31
2.27
1.10
1.6
2.4
110.3
129.3
%
—
7
31
14
81
1.74
1.09
1.9
1.8
29.6
57.1
%
—
7
54
70
864
0.80
1.06
1.6
2.3
25.4
24.7
%
0.14
57
749
6
124
0.48
1.05
1.5
2.7
—
645.0
—
0
10
197
1751
1.16
1.04
1.9
2.1
—
—
—
0
0
128
1099
1.19
1.03
3.4
3.4
19.5
21.2
%
0.59
47
413
78
638
1.24
1.02
3.4
3.6
4.5
4.6
pmol/l
0.64
70
574
5
109
0.46
1.01
1.0
1.6
—
—
—
0
0
46
593
0.76
1.00
1.9
2.2
77.2
76.0
ml/min/173m2
0.08
20
234
9
158
0.57
0.99
2.9
5.9
—
322.8
—
0
22
66
532
1.26
0.99
1.4
1.4
—
—
—
0
0
22
148
1.50
0.98
1.2
1.4
6.6
7.3
mmol/l
0.58
13
107
14
84
1.68
0.98
2.3
1.7
20.1
20.2
nmol/l
0.03
14
78
0
29
0.00
0.98
0.0
2.6
—
—
—
0
0
869
8495
1.18
0.97
9.3
10.8
16.0
20.0
mg/l
3.25
668
6539
6
118
0.51
0.94
1.2
1.3
—
—
—
0
0
6
118
0.51
0.94
1.2
1.3
—
—
—
0
0
6
27
2.23
0.93
1.2
1.1
—
—
—
0
0
25
175
1.44
0.93
1.0
1.0
2.1
1.6
u/ml
0.24
18
86
50
393
1.29
0.92
1.5
1.6
—
—
—
0
0
457
4309
1.11
0.92
3.0
4.5
6.2
6.4
mmol/l
1.70
412
3959
20
134
1.50
0.92
1.5
2.7
5.1
5.0
kpa
0.33
20
134
826
8055
1.15
0.90
3.3
3.4
1.3
1.3
mmol/l
0.12
800
7632
21
301
0.69
0.90
1.5
1.6
—
—
—
0
0
91
769
1.20
0.89
1.9
2.0
364.8
369.5
nmol/l
0.07
84
719
718
6943
1.12
0.89
3.3
3.6
—
—
—
0
0
9
155
0.58
0.88
1.0
1.2
—
—
—
0
0
176
1573
1.14
0.87
1.8
2.0
—
—
—
0
0
8
43
1.87
0.87
2.0
3.3
858.1
547.2
u/ml
—
8
43
94
1099
0.84
0.86
2.2
2.5
2.4
2.4
mmol/l
0.23
88
974
95
809
1.19
0.86
1.2
1.2
73.0
151.5
iu/ml
2.78
35
338
24
332
0.72
0.85
1.6
1.4
—
—
—
0
0
12
190
0.63
0.83
2.3
2.4
108.3
278.0
ug/l
2.27
12
175
43
338
1.28
0.81
1.1
1.3
9.4
10.5
u/l
0.23
35
274
13
200
0.65
0.80
1.0
1.7
—
—
—
0
0
13
200
0.65
0.80
1.0
1.7
4.0
3.9
g/l
—
7
153
13
200
0.65
0.80
1.0
1.7
6.4
7.3
g/l
—
7
164
12
188
0.63
0.80
2.2
1.6
—
—
—
0
0
45
357
1.27
0.80
1.9
2.7
64.5
121.6
ng/l
2.16
39
314
175
1939
0.88
0.80
1.9
2.2
1755.1
4219.6
umol/l
0.83
161
1741
759
7382
1.12
0.79
11.2
13.0
13.3
13.5
%
1.65
745
7247
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
855
8378
1.14
0.77
3.7
3.8
5.0
4.8
mmol/l
3.26
824
7993
35
270
1.31
0.77
1.2
1.7
0.2
0.2
g/l
0.15
30
257
15
221
0.67
0.76
1.5
1.5
—
—
—
0
0
0
28
0.00
0.76
0.0
1.7
—
—
—
0
0
0
28
0.00
0.76
0.0
1.7
—
—
—
0
0
0
28
0.00
0.76
0.0
1.7
—
—
—
0
0
118
1338
0.87
0.76
1.7
1.8
1.3
1.4
%
1.66
110
1209
18
255
0.70
0.75
1.1
1.2
—
—
—
0
0
18
254
0.70
0.74
1.1
1.2
—
—
—
0
0
9
56
1.61
0.72
1.8
1.8
—
—
—
0
0
6
110
0.54
0.72
3.0
1.5
—
—
—
0
0
13
194
0.67
0.71
1.0
1.2
—
—
—
0
0
87
751
1.17
0.71
1.2
1.3
27.5
28.0
iu/l
0.05
81
634
5
26
1.93
0.70
2.2
1.5
8.0
7.9
ug/l
—
5
26
7
41
1.71
0.70
1.3
1.7
0.7
2.7
nmol/l
—
7
32
851
8359
1.12
0.63
3.6
3.8
1.5
1.5
mmol/l
1.61
821
7931
189
2055
0.90
0.63
2.1
3.1
8.3
8.1
mmol/l
0.15
178
1773
815
7988
1.11
0.63
3.5
3.7
5.6
5.7
mmol/l
6.47
788
7502
13
188
0.69
0.62
2.1
1.6
—
—
—
0
0
243
2607
0.91
0.62
1.6
1.8
99.9
97.5
pmol/l
0.39
130
1408
35
280
1.26
0.61
1.2
1.7
1.2
1.2
g/l
0.25
30
266
231
2146
1.10
0.61
1.3
1.3
1.3
1.5
u/ml
0.15
85
630
76
659
1.17
0.60
2.4
2.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
23
174
1.33
0.60
1.1
1.1
2.2
4.7
u/ml
1.06
13
68
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
2.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
8
52
1.54
0.59
2.0
2.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
14
97
1.45
0.59
1.1
1.1
—
—
—
0
0
37
452
0.81
0.58
1.6
1.7
—
—
—
0
0
7
115
0.61
0.58
1.6
1.4
—
—
—
0
0
15
106
1.42
0.58
1.0
1.1
—
—
—
0
0
50
591
0.84
0.57
1.3
1.5
—
—
—
0
0
12
172
0.69
0.56
1.8
2.8
—
—
—
0
0
25
194
1.30
0.56
1.2
1.1
7.6
3.7
u/ml
0.34
16
74
219
2345
0.92
0.54
2.1
3.3
2.4
2.4
mmol/l
0.08
204
2141
14
99
1.42
0.54
1.6
1.5
—
12.8
—
0
20
208
1936
1.09
0.54
1.5
1.7
0.7
0.9
mg/l
1.02
155
1445
27
214
1.27
0.53
1.1
1.1
0.9
2.0
u/ml
0.77
13
55
35
288
1.22
0.50
1.5
2.1
—
—
—
0
0
10
67
1.50
0.49
1.1
1.4
10.1
10.1
umol/l
—
10
62
36
298
1.22
0.49
1.4
1.5
—
—
—
0
0
802
7881
1.09
0.49
7.4
9.1
90.4
90.6
ml/min/173m2
0.16
687
6449
40
335
1.20
0.49
2.2
3.3
141.1
131.5
g/l
2.54
40
328
143
1314
1.10
0.49
2.1
2.7
494.0
678.4
ng/l
0.47
116
1063
7
108
0.65
0.48
2.9
2.4
3.7
4.2
u/ml
—
7
94
27
217
1.25
0.48
1.4
1.4
14.7
24.1
u/l
1.45
18
184
190
2035
0.92
0.48
1.7
2.1
135.7
191.7
u/l
1.00
176
1939
129
1406
0.91
0.47
1.3
1.4
22.5
21.1
nmol/l
0.47
117
1248
18
233
0.77
0.47
1.3
1.4
0.3
0.4
nmol/l
0.07
13
186
12
165
0.72
0.46
4.0
4.1
55.0
56.6
%
0.16
12
165
536
5198
1.07
0.46
3.5
3.6
1264.3
297.0
e6/l
—
9
59
96
1061
0.89
0.46
1.5
2.2
15.9
14.6
umol/l
0.92
87
987
5
81
0.62
0.46
3.0
1.6
—
—
—
0
0
858
8464
1.10
0.45
3.9
4.1
3.0
2.9
mmol/l
3.13
826
8018
39
459
0.84
0.45
1.5
1.6
—
—
—
0
0
38
448
0.84
0.44
1.4
1.4
—
—
—
0
0
11
152
0.72
0.44
1.2
1.1
—
—
—
0
0
20
252
0.79
0.44
1.6
1.4
80.5
135.6
pmol/l
0.47
20
247
88
972
0.90
0.42
1.6
2.1
28.0
29.4
s
2.61
82
947
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
790003.8
—
0
10
0
15
0.00
0.41
0.0
2.3
—
0.7
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
73
813
0.89
0.41
4.7
5.2
—
—
—
0
0
50
436
1.15
0.41
1.9
1.9
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
148
1377
1.09
0.40
4.3
3.6
1.6
1.6
ug/l
0.06
139
1263
5
34
1.47
0.40
1.6
1.1
—
—
—
0
0
61
686
0.88
0.40
2.0
1.7
—
—
—
0
0
7
105
0.66
0.39
1.7
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
12
159
0.75
0.38
3.3
3.8
4.0
4.1
e9/l
0.09
12
159
88
965
0.90
0.38
1.5
2.2
2.6
2.4
g/l
2.78
80
898
105
1141
0.91
0.38
2.0
1.6
—
—
—
0
0
39
449
0.86
0.36
1.4
1.4
—
—
—
0
0
639
6260
1.06
0.36
2.6
3.0
41.2
41.3
u/l
0.00
618
5997
303
2909
1.06
0.35
3.3
3.2
27.9
30.3
u/l
0.77
289
2780
168
1582
1.07
0.35
1.2
1.3
11.0
10.7
u/ml
0.02
82
665
31
265
1.18
0.34
1.2
1.1
—
—
—
0
0
15
118
1.28
0.33
2.2
2.1
16.6
17.3
%
—
7
56
10
74
1.35
0.32
1.0
1.1
—
—
—
0
0
7
52
1.35
0.31
1.3
2.5
—
—
—
0
0
7
97
0.72
0.31
1.0
1.1
—
—
—
0
0
12
153
0.78
0.31
1.0
1.2
—
—
—
0
0
40
451
0.88
0.30
1.4
1.4
—
—
—
0
0
8
107
0.75
0.29
1.0
1.1
—
—
—
0
0
40
450
0.88
0.29
1.4
1.4
—
—
—
0
0
7
57
1.23
0.29
1.7
1.5
—
—
—
0
0
23
270
0.85
0.29
1.7
2.0
4.5
4.9
iu/l
—
8
110
8
111
0.72
0.28
1.6
1.9
—
—
—
0
0
13
162
0.80
0.28
1.0
1.1
—
—
—
0
0
57
625
0.91
0.27
17.6
13.7
1.1
1.2
inr
0.27
20
101
339
3289
1.05
0.27
3.8
6.4
1.2
1.2
mmol/l
0.78
288
2789
32
363
0.88
0.26
1.7
2.9
0.8
1.6
mmol/l
1.08
21
268
14
113
1.24
0.26
1.1
1.3
—
—
—
0
0
173
1651
1.06
0.26
1.3
1.3
29.9
27.0
iu/ml
0.14
60
527
16
191
0.84
0.24
1.1
1.3
4.0
3.7
mmol/l
0.27
16
178
281
2898
0.96
0.23
3.7
4.8
37.3
36.8
g/l
0.84
267
2726
87
815
1.07
0.23
2.8
2.5
0.7
0.6
ug/l
0.07
42
448
253
2448
1.04
0.23
2.3
2.8
19.6
33.7
ng/l
1.01
123
1285
37
333
1.12
0.22
1.6
1.8
—
—
—
0
0
15
178
0.84
0.22
1.8
1.6
—
—
—
0
0
62
668
0.92
0.22
2.0
1.7
—
—
—
0
0
19
220
0.86
0.21
1.3
1.4
312.5
311.4
ug/g
—
10
123
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
23
201
1.15
0.21
1.2
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
8
102
0.78
0.21
1.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.2
1.1
2521.2
1596.0
miu/ml
—
5
43
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
22
193
1.14
0.19
1.8
4.5
1.5
1.3
mmol/l
0.36
22
188
177
1835
0.96
0.19
3.0
4.0
5.2
10.6
mg/mmol
1.29
123
1171
103
979
1.06
0.19
1.5
1.6
1192.6
1193.2
nmol/l
0.00
85
776
14
118
1.19
0.19
1.9
1.5
—
—
—
0
0
178
1843
0.96
0.18
1.9
2.0
—
—
—
0
0
10
82
1.22
0.17
2.0
1.5
—
—
—
0
0
5
70
0.71
0.16
1.0
1.1
267.2
286.3
mg/l
—
5
65
8
72
1.11
0.16
4.6
3.3
26.1
51.5
u/ml
—
8
72
104
996
1.05
0.16
2.0
1.8
—
—
—
0
0
180
1749
1.04
0.14
1.8
2.0
2.7
2.8
mg/l
0.25
164
1519
9
109
0.82
0.13
1.1
1.1
1.3
1.4
g/l
—
9
101
17
190
0.89
0.13
1.2
1.6
158.9
1080.1
e6/l
0.74
17
155
19
171
1.11
0.12
1.2
2.7
0.7
0.9
nmol/l
0.77
14
147
15
133
1.13
0.12
1.9
1.5
—
—
—
0
0
86
827
1.04
0.12
1.9
1.8
—
—
—
0
0
30
279
1.08
0.11
1.3
1.3
—
—
—
0
0
18
163
1.11
0.11
1.0
1.1
—
—
—
0
0
86
831
1.04
0.10
1.5
1.5
—
—
—
0
0
5
44
1.14
0.10
1.4
1.7
—
—
—
0
0
326
3303
0.98
0.09
2.0
2.2
78.0
74.8
nmol/l
1.41
311
3067
11
97
1.14
0.09
1.1
1.3
—
—
—
0
0
15
165
0.91
0.09
1.2
1.2
3.2
6.2
u/ml
—
5
63
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
16
175
0.91
0.08
1.4
1.4
—
—
—
0
0
60
623
0.96
0.08
3.1
10.2
1.3
1.1
mmol/l
0.16
37
490
53
552
0.96
0.08
1.0
1.0
—
—
—
0
0
5
65
0.77
0.08
1.2
1.2
—
—
—
0
0
11
98
1.12
0.07
1.1
1.3
—
—
—
0
0
11
98
1.12
0.07
1.1
1.3
—
—
—
0
0
11
98
1.12
0.07
1.3
1.2
—
—
—
0
0
6
70
0.86
0.07
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.0
1.1
—
—
—
0
0
6
72
0.83
0.07
1.5
1.4
—
—
—
0
0
6
73
0.82
0.07
1.0
1.2
70.8
55.6
u/l
—
6
49
49
509
0.96
0.07
1.4
1.5
—
—
—
0
0
44
458
0.96
0.07
1.7
1.7
3.2
4.8
mg/l
0.50
31
310
11
99
1.11
0.06
1.1
1.3
—
—
—
0
0
474
4710
1.01
0.05
7.1
8.5
3.7
4.0
e9/l
3.29
443
4159
19
178
1.07
0.05
1.5
1.8
—
—
—
0
0
11
100
1.10
0.05
1.1
1.3
—
—
—
0
0
11
100
1.10
0.05
1.1
1.3
—
—
—
0
0
51
497
1.03
0.04
2.2
3.3
2.2
1.9
mmol/l
0.32
38
406
19
199
0.95
0.03
1.6
1.2
—
—
—
0
0
105
1063
0.99
0.03
2.0
1.9
—
—
—
0
0
735
7366
0.99
0.03
4.3
4.5
37.9
38.3
mmol/mol
0.28
707
7003
18
173
1.04
0.01
1.1
1.3
—
—
—
0
0
139
1381
1.01
0.01
1.9
2.3
5.6
7.8
e6/l
0.71
122
1216
14
146
0.96
0.00
1.0
1.1
11.8
3697.0
iu/ml
—
5
35
829
8286
1.00
0.00
9.5
11.3
39.9
40.4
%
0.75
650
6786
122
1221
1.00
0.00
2.1
3.0
283.7
444.3
ng/l
0.33
55
726
15
151
0.99
0.00
2.4
2.3
308.0
164.0
ug/min
—
9
98
49
493
0.99
0.00
1.4
1.5
—
—
—
0
0
61
615
0.99
0.00
2.4
2.3
21.7
23.5
au/ml
—
7
50
20
195
1.03
0.00
1.7
2.0
2.8
4.5
umol/l
3.26
13
142
14
135
1.04
0.00
1.1
1.1
—
—
—
0
0
10
95
1.05
0.00
2.0
1.5
—
—
—
0
0
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
7
72
0.97
0.00
1.4
1.5
1.0
1.0
g/l
—
7
72
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
5
58
0.86
0.00
5.0
2.3
0.2
0.2
e9/l
—
5
52
390
3900
1.00
0.00
4.0
5.8
9.4
10.3
umol/l
1.97
374
3695
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
77
0.91
0.00
1.4
1.4
38.5
36.2
nmol/l
—
7
64
6
61
0.98
0.00
4.0
2.3
628.0
498.0
e6/l
—
6
53
6
69
0.87
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
9
97
0.93
0.00
2.4
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
5
50
1.00
0.00
1.0
1.6
—
73.7
%
—
0
7
6
69
0.87
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
6.3
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
6
59
1.02
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_MN_RETRGN_AND_SURG and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_MN_RETRGN_AND_SURG.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_MN_RETRGN_AND_SURG – Mandibular retrognathia AND surgery (BSSRO)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data