No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1086 |
4. Check minimum number of eventsNone |
1086 |
5. Include endpointsNone |
1086 |
6. Filter based on genotype QC (FinnGen only) |
1086 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
LSIL lesion of the vulva
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the vulva
- LSIL lesion of the cervix uteri, vagina or vulva
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6816 | 6816 | - |
| Only index persons | 6423 | 6423 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.20 | - |
| Only index persons | 0.24 | 0.24 | - |
| Median age at first event (years) | |||
| Whole population | - | 32.01 | - |
| Only index persons | - | 31.60 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1086 | 1086 | - |
| Unadjusted period prevalence (%) | 0.37 | 0.37 | - |
| Median age at first event (years) | 32.66 | 32.66 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 965
- Matched controls
- 9650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
+∞
323.0
587
*
N90.0
ICD-10 Finland
Mild vulvar dysplasia
+∞
323.0
379
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
24.9
183.0
266
145
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
201.5
164.5
167
10
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
235.5
139.9
141
7
ULA02
NOMESCO Finland
Kolposcopy
7.0
131.0
389
849
8411
FHL
Local change laser, coagulation, biopsy or removal
148.6
101.3
106
8
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.0
67.2
329
1097
LEB00
NOMESCO Finland
Biopsy of vagina
13.7
60.3
107
87
8326
FHL
Batch conization
29.9
49.8
67
24
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
4.3
46.6
194
535
A63.0
ICD-10 Finland
Anogenital (venereal) warts
6.6
43.7
119
202
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
17.9
42.6
67
40
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
71.9
42.4
48
7
N89.0
ICD-10 Finland
Mild vaginal dysplasia
28.2
41.2
56
21
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.3
40.3
242
896
D06BB04
ATC
podophyllotoxin; topical
4.9
35.7
124
281
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
6.9
35.4
92
146
D06BB10
ATC
imiquimod; topical
5.4
30.8
96
192
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
15.6
29.8
49
33
6221A
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI LEVIS]
51.8
29.5
35
7
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
32.9
29.2
38
12
N87.0
ICD-10 Finland
Mild cervical dysplasia
5.8
28.6
84
156
1390
FHL
Colposcopy
66.1
28.1
32
5
8111
FHL
Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)
38.6
24.0
30
8
LFC00
NOMESCO Finland
Partial excision of vulva
38.6
24.0
30
8
LDA10
NOMESCO Finland
Curettage of cervix uteri
3.7
23.7
109
320
6221B
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI MODERATA]
41.2
22.8
28
7
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
17.6
21.9
34
20
8113
FHL
Fractional scraping
3.5
21.2
103
315
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
3.2
17.3
94
313
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
17.1
435
3004
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
32.1
17.1
22
7
7950A
ICD-9 Finland
Nonspecific abnormal histological and immunological findings, Nonspecific abnormal Papanicolaou smear of cervix
35.7
16.7
21
6
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
13.0
16.7
29
23
J02AC01
ATC
fluconazole; systemic
1.8
16.5
561
4234
D07AD01
ATC
clobetasol; topical
2.2
15.9
186
955
8339
FHL
Other measure in this category
26.8
15.6
21
8
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
45.8
15.1
18
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
14.8
275
1691
P01AB01
ATC
metronidazole; oral, rectal
1.7
14.1
460
3364
N02AX02
ATC
tramadol; systemic, rectal
1.7
11.9
382
2735
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.9
11.9
49
132
G01AF04
ATC
miconazole; vaginal
2.5
11.7
97
420
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.7
11.1
37
82
G01AF01
ATC
metronidazole; vaginal
1.9
10.8
171
978
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
60.7
10.6
12
*
N87.1
ICD-10 Finland
Moderate cervical dysplasia
3.6
10.5
46
131
6350C
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,SOSIAALISET SYYT]
2.2
10.3
107
516
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
10.1
74
298
N90.4
ICD-10 Finland
Leukoplakia of vulva
11.4
10.1
18
16
6221C
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI GRAVIS]
12.3
9.9
17
14
A10AA01
ATC
NA
3.8
9.8
40
108
A10AA02
ATC
NA
3.6
9.7
43
125
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.7
9.6
40
110
G01AA10
ATC
clindamycin; vaginal
1.7
9.5
236
1553
8112
FHL
Scraping the cervix
17.7
9.4
14
8
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
30.3
9.4
12
*
N03AX16
ATC
pregabalin; oral
1.7
9.3
234
1548
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
9.6
9.3
18
19
A02BC02
ATC
pantoprazole; systemic
1.5
9.1
614
5149
R4110
NOMESCO Finland
Physiotherapy
1.7
9.1
239
1601
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
9.0
443
3455
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.7
8.9
226
1496
127
Kela drug reimbursment
Transplant complication
6.0
8.8
23
39
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
50.5
8.7
10
*
WX002
NOMESCO Finland
Sedation and analgesia
1.7
8.5
172
1065
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
3.8
8.5
34
91
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
5.3
8.3
24
46
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
8.2
285
2040
J01FF01
ATC
clindamycin; systemic
1.6
8.2
260
1821
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
22.2
8.0
11
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.8
334
2501
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.8
7.8
49
181
J01DA01
ATC
[U] cefalexin; systemic
1.5
7.5
617
5274
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
2.9
7.5
44
157
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.6
7.5
53
213
N30.0
ICD-10 Finland
Acute cystitis
1.8
7.5
144
877
7020X
ICD-9 Finland
Other dermatoses, Actinic keratosis[DERMATOSES PRAECANCEROSAE ALIAE]
80.7
7.4
8
*
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
80.7
7.4
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.2
326
2460
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
4.1
7.2
26
64
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
4.6
7.1
23
51
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.4
7.1
20
38
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.0
167
1080
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
7.0
98
537
G01AF02
ATC
clotrimazole; vaginal
2.3
6.9
65
300
8511
FHL
Cervical dilation and drainage with suction
2.2
6.9
70
336
TLC02
NOMESCO Finland
Simple extraction of IUD
2.1
6.9
73
359
UJF32
NOMESCO Finland
Coloscopy
1.6
6.9
210
1450
C03CA01
ATC
furosemide; systemic
1.6
6.9
166
1081
8513
FHL
Softening of cervix with abortifacient or laminars and associated surgical emptying of the uterus
2.5
6.8
52
218
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.3
6.8
60
271
R32
ICD-10 Finland
Unspecified urinary incontinence
3.2
6.8
33
105
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
40.3
6.8
8
*
ZX120
NOMESCO Finland
Intravenous
2.0
6.7
84
441
TQW40
NOMESCO Finland
Remowal of suture of skin
2.2
6.7
66
313
K02.1
ICD-10 Finland
Caries of dentine
1.4
6.7
535
4504
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
6.6
239
1714
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.4
6.6
30
91
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
6.6
299
2255
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.8
6.5
40
149
N01BB02
ATC
lidocaine; parenteral
5.4
6.5
18
34
N06AB06
ATC
sertraline; oral
1.8
6.5
117
699
J01MA12
ATC
levofloxacin; systemic
1.7
6.5
144
914
L29.2
ICD-10 Finland
Pruritus vulvae
3.6
6.4
27
77
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.4
341
2652
H3603, E103
ICD-10 Finland
NA
4.9
6.4
19
39
A02BC05
ATC
esomeprazole; systemic
1.4
6.3
379
3012
A10AE05
ATC
insulin detemir; parenteral
2.5
6.3
46
190
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.3
221
1575
D07AC01
ATC
betamethasone; topical
1.5
6.3
299
2274
M01AH05
ATC
etoricoxib; oral
1.4
6.3
574
4922
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
6.3
6
*
TAC99
NOMESCO Finland
Other blockade for chronic pain
7.1
6.2
14
20
WX320
NOMESCO Finland
Spinalanesthesy
1.6
6.2
188
1292
A11CC03
ATC
alfacalcidol; systemic
4.0
6.2
23
59
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.7
6.1
135
855
J01DB01
ATC
cefalexin; oral
1.5
6.1
769
6989
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
6.1
82
443
M54.5
ICD-10 Finland
Low back pain
1.4
6.1
312
2404
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
8.7
6.1
12
14
TQW99
NOMESCO Finland
Other minor procedure on skin
2.5
6.1
44
181
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
58
7.68
30.29
2.6
1.6
—
—
—
0
0
145
601
2.63
23.20
2.2
1.4
—
—
—
0
0
407
2638
1.87
20.55
2.2
1.4
—
—
—
0
0
226
1207
2.10
19.97
3.3
2.5
4.7
4.8
e6/l
0.02
135
587
217
1335
1.78
12.02
3.1
2.4
1.2
1.2
e6/l
0.04
126
715
164
938
1.88
11.48
9.7
4.5
1.1
1.0
mmol/l
0.80
156
859
478
3649
1.55
11.13
6.2
4.0
35.8
36.3
g/l
1.35
461
3406
313
2224
1.57
9.72
4.4
2.7
0.2
0.4
e6/l
2.22
242
1637
445
3417
1.51
9.68
2.0
1.9
101.4
99.3
pmol/l
0.36
233
1710
105
547
2.02
9.63
12.5
6.5
8.6
8.2
mmol/l
0.33
100
524
41
140
3.00
9.43
8.0
4.7
527.0
173.1
iu/ml
0.73
11
14
293
2082
1.56
9.00
2.5
2.1
—
—
—
0
0
485
3834
1.48
8.93
8.0
5.0
1.2
1.2
mmol/l
0.72
458
3500
166
1026
1.73
8.89
3.7
2.2
21.4
22.9
%
0.89
152
874
200
1302
1.66
8.82
4.3
2.9
0.8
0.8
mmol/l
0.67
193
1216
194
1259
1.66
8.65
3.3
2.1
13.1
13.6
umol/l
0.44
185
1158
179
1139
1.68
8.60
3.5
2.1
2.4
2.4
g/l
0.97
167
1059
102
551
1.94
8.44
2.1
1.6
—
—
—
0
0
48
192
2.57
8.24
1.3
1.3
—
—
—
0
0
127
744
1.80
8.16
5.5
4.5
228.5
256.1
u/l
1.08
122
707
643
5431
1.45
8.05
12.0
8.6
3.9
3.9
e9/l
0.04
579
4789
135
831
1.71
7.30
15.8
18.0
1.2
1.2
inr
0.04
16
127
258
1869
1.50
7.02
1.6
1.5
23.6
22.0
nmol/l
0.37
234
1623
316
2389
1.46
6.92
4.4
2.9
6.4
6.9
mmol/l
1.17
258
2034
795
7079
1.46
6.90
4.8
4.0
12.2
11.2
mm/h
1.21
756
6615
519
4291
1.40
6.87
8.8
5.7
1.2
1.2
mmol/l
1.32
476
3618
361
2802
1.43
6.85
2.8
2.3
53.8
56.3
u/l
0.68
345
2592
303
2309
1.43
6.26
5.3
3.7
11.3
7.0
mg/mmol
0.67
192
1324
69
362
1.97
6.25
1.4
1.7
—
—
—
0
0
169
1146
1.56
6.19
1.9
1.9
—
—
—
0
0
391
3121
1.40
6.19
3.9
2.8
34.1
29.9
u/l
0.54
377
2986
120
752
1.67
6.07
2.6
3.4
4.3
4.5
pmol/l
1.09
103
669
55
269
2.10
6.03
1.5
1.4
323.4
312.1
ug/g
0.14
35
151
256
1910
1.45
5.89
2.9
2.7
966.7
821.1
ng/l
0.32
220
1600
219
1586
1.48
5.88
2.7
2.6
2.4
2.4
mmol/l
0.02
180
1409
573
4892
1.36
5.88
5.9
4.1
6.7
6.5
mmol/l
1.00
545
4547
54
266
2.08
5.82
2.9
2.1
1.4
1.5
g/l
0.52
47
236
549
4667
1.36
5.73
7.1
5.5
9.0
9.9
umol/l
2.58
539
4425
500
4190
1.36
5.73
2.9
2.2
78.2
78.0
nmol/l
0.07
458
3839
151
1021
1.56
5.59
1.8
1.8
—
—
—
0
0
34
141
2.46
5.50
1.6
1.3
110.6
123.7
u/ml
—
5
29
37
160
2.36
5.47
1.5
1.6
—
—
—
0
0
77
439
1.81
5.44
1.8
1.5
—
—
—
0
0
146
988
1.55
5.38
2.9
2.3
5.3
5.9
umol/l
0.32
127
847
16
43
3.76
5.38
1.1
1.1
—
—
—
0
0
19
58
3.32
5.32
1.8
2.7
662.7
693.5
e6/l
—
6
24
200
1462
1.45
5.07
3.9
3.4
101.2
327.6
ng/l
2.07
123
945
275
2130
1.39
5.03
2.3
2.1
3.1
2.9
mg/l
0.45
252
1821
528
4520
1.33
5.00
6.0
4.8
0.0
0.0
estimate
0.50
77
845
225
1689
1.42
4.93
4.1
2.3
6.1
8.1
e6/l
1.39
196
1491
178
1279
1.47
4.93
1.9
2.2
174.4
101.3
ug/g
0.92
141
1008
532
4567
1.32
4.91
4.4
3.6
0.0
0.0
estimate
1.06
73
831
780
7083
1.36
4.85
9.6
6.8
74.6
75.9
u/l
0.56
740
6691
8
7
11.50
4.79
5.6
4.3
—
—
—
0
0
989
9384
1.60
4.73
17.7
11.7
19.0
19.4
mg/l
0.19
814
7239
86
529
1.68
4.69
2.3
2.7
202.6
145.2
ng/l
0.50
75
473
34
153
2.26
4.63
1.4
1.2
336.3
286.5
u/ml
0.41
27
95
154
1091
1.48
4.57
1.7
1.6
1.4
1.3
%
0.28
131
981
189
1396
1.43
4.51
1.8
1.7
1218.9
1202.8
nmol/l
0.08
160
1059
104
680
1.59
4.46
5.4
3.1
104.4
73.8
ng/l
1.56
94
606
36
169
2.17
4.45
1.3
1.2
—
—
—
0
0
522
4517
1.30
4.36
3.4
2.8
98.0
81.7
ug/l
1.14
503
4251
56
312
1.84
4.31
1.2
1.1
—
—
—
0
0
90
575
1.62
4.26
1.5
1.6
—
—
—
0
0
309
2500
1.33
4.18
1.7
1.6
1.4
1.4
mmol/l
0.28
271
2161
11
27
4.11
4.17
1.0
1.3
—
—
—
0
0
518
4497
1.29
4.15
4.4
3.5
0.0
0.0
estimate
0.00
73
846
55
309
1.82
4.13
1.2
1.2
—
—
—
0
0
957
9062
1.47
4.11
5.9
5.2
1.8
2.1
mu/l
0.90
899
8512
490
4231
1.29
4.06
4.3
3.7
—
—
—
0
0
65
387
1.72
4.03
1.6
1.6
—
—
—
0
0
119
822
1.50
4.01
2.3
2.2
32.1
37.5
u/l
0.77
101
690
110
750
1.52
3.94
2.3
2.2
62.1
73.1
ml/min/173m2
1.61
41
293
107
730
1.52
3.82
1.7
1.7
—
—
—
0
0
65
393
1.70
3.82
2.9
3.1
1.5
1.8
mmol/l
0.29
49
303
11
29
3.82
3.81
1.0
1.3
—
—
—
0
0
92
609
1.56
3.77
1.5
1.5
—
—
—
0
0
22
90
2.47
3.73
1.9
1.8
20.6
19.0
mg/l
0.07
11
30
373
3139
1.29
3.70
4.0
3.4
2.4
2.4
mmol/l
0.30
331
2811
294
2406
1.30
3.59
1.4
1.3
2.3
1.7
u/ml
0.20
86
661
18
68
2.67
3.57
1.3
1.3
—
—
—
0
0
18
68
2.67
3.57
1.3
1.3
—
—
—
0
0
27
124
2.21
3.56
1.4
1.3
—
—
—
0
0
93
628
1.53
3.50
6.2
3.0
2.1
2.2
mmol/l
0.11
78
504
938
8902
1.39
3.48
15.3
10.4
84.3
84.8
ml/min/173m2
0.27
804
7345
153
1140
1.40
3.47
3.0
1.9
28.4
29.4
s
1.47
148
1104
44
245
1.83
3.44
1.3
1.2
—
—
—
0
0
305
2522
1.29
3.43
2.2
2.1
120.2
160.4
u/l
0.81
294
2387
30
147
2.07
3.38
1.5
1.3
—
—
—
0
0
30
147
2.07
3.38
1.5
1.3
—
—
—
0
0
24
109
2.23
3.27
1.2
1.2
—
—
—
0
0
127
927
1.42
3.24
1.9
2.0
388.1
371.5
nmol/l
0.39
119
860
88
604
1.50
3.09
8.1
5.9
1.0
1.3
mmol/l
3.69
82
580
28
139
2.04
3.08
1.1
1.5
—
—
—
0
0
77
515
1.53
3.06
5.1
2.5
4.8
4.6
kpa
0.31
71
496
711
6546
1.25
3.03
3.3
2.9
42.9
39.2
u/l
0.64
683
6205
33
177
1.89
2.93
1.9
2.7
—
—
—
0
0
1029
9990
1.57
2.84
12.7
9.5
23.7
24.0
u/l
0.24
1008
9727
16
65
2.48
2.80
1.1
1.2
—
—
titre
—
0
0
5
6
8.36
2.75
4.8
6.7
4.0
6.9
mmol/l
—
5
6
69
463
1.52
2.72
1.4
1.3
0.3
1.0
u/ml
—
10
43
51
321
1.62
2.65
3.5
1.9
0.2
0.2
g/l
1.23
51
303
851
8050
1.26
2.59
5.0
4.4
14.7
14.5
pmol/l
1.58
798
7528
247
2054
1.26
2.59
1.4
1.3
25.8
28.6
iu/ml
0.19
67
667
56
364
1.57
2.56
2.8
2.0
—
—
—
0
0
30
164
1.85
2.55
3.6
2.7
24.5
25.4
mmol/l
0.74
25
146
28
150
1.89
2.53
1.4
1.8
—
—
—
0
0
10
33
3.05
2.53
1.1
1.7
—
—
—
0
0
10
33
3.05
2.53
1.1
1.7
—
—
—
0
0
65
439
1.51
2.51
1.8
1.9
2282.6
3435.9
u/l
0.20
22
162
14
57
2.48
2.45
2.2
2.1
—
—
—
0
0
16
70
2.30
2.42
1.1
1.2
—
—
—
0
0
231
1921
1.26
2.41
4.6
3.9
1.0
1.0
kg/l
0.62
34
274
43
267
1.64
2.38
1.4
1.6
—
160.0
—
0
12
151
1193
1.31
2.36
2.0
1.7
—
—
—
0
0
267
2268
1.24
2.30
2.0
1.7
1.0
0.8
mg/l
0.51
202
1707
261
2213
1.24
2.29
3.0
2.2
2906.3
4194.2
umol/l
0.29
231
1948
51
336
1.54
2.23
3.6
1.9
1.1
1.2
g/l
2.16
51
315
14
60
2.35
2.22
1.8
2.1
10.3
12.7
%
—
8
28
133
1042
1.31
2.22
4.4
4.1
32.3
33.1
%
0.38
97
730
46
297
1.57
2.20
1.5
1.4
36.5
29.9
u/l
0.64
40
246
979
9474
1.34
2.18
18.7
12.3
139.6
139.7
mmol/l
0.95
966
9257
346
3034
1.21
2.16
3.7
3.0
22.7
40.9
ng/l
0.65
201
1705
938
9030
1.28
2.13
4.2
3.7
1.3
1.2
mmol/l
1.65
883
8456
24
130
1.87
2.13
1.3
1.4
6.8
7.2
mmol/l
0.30
18
95
5
10
5.02
2.07
1.0
1.0
5.7
5.7
nmol/l
—
5
10
108
830
1.33
2.07
3.7
3.7
3.5
15.8
ug/l
1.46
86
649
980
9499
1.32
2.04
19.3
12.4
3.9
3.9
mmol/l
1.14
966
9257
101
775
1.33
1.96
7.4
7.3
1.3
1.3
mmol/l
0.05
83
611
242
2071
1.22
1.92
1.6
1.5
—
—
—
0
0
46
309
1.51
1.88
1.3
1.3
10.2
10.1
u/ml
—
6
61
58
411
1.43
1.83
2.3
2.2
45.3
39.3
u/l
1.16
53
373
5
12
4.18
1.82
1.2
1.0
—
—
—
0
0
879
8438
1.22
1.81
6.5
4.9
39.9
38.7
mmol/mol
3.00
828
7933
17
90
1.90
1.65
1.2
1.2
57.0
55.2
u/l
0.07
12
64
71
534
1.35
1.61
2.2
2.2
4.4
5.0
ug/l
0.21
66
468
79
605
1.33
1.60
1.7
2.6
65.0
67.7
g/l
1.92
71
565
102
810
1.29
1.59
1.9
1.6
—
—
—
0
0
13
64
2.04
1.54
1.7
2.2
3.0
2.1
u/field
—
8
34
5
15
3.34
1.52
2.6
2.3
23.5
24.5
umol/l
—
5
15
7
27
2.60
1.51
1.3
2.1
—
—
—
0
0
7
27
2.60
1.51
1.3
2.1
—
—
—
0
0
7
27
2.60
1.51
1.0
1.3
—
—
—
0
0
7
27
2.60
1.51
1.0
1.3
—
—
—
0
0
7
27
2.60
1.51
1.3
2.1
—
—
—
0
0
81
1031
0.77
1.50
1.7
1.7
—
—
—
0
0
44
312
1.43
1.43
1.9
1.9
—
—
—
0
0
23
141
1.64
1.42
1.1
1.3
0.4
0.6
nmol/l
2.85
23
135
101
814
1.27
1.42
1.9
1.7
—
—
—
0
0
30
197
1.54
1.41
1.5
1.3
—
—
—
0
0
33
222
1.50
1.40
1.3
1.6
—
—
—
0
0
23
142
1.63
1.39
1.1
1.3
—
0.4
nmol/l
—
0
5
26
166
1.58
1.38
1.9
1.9
121.7
131.4
g/l
1.44
20
120
6
23
2.62
1.37
1.0
1.0
—
—
—
0
0
385
3521
1.14
1.34
4.5
3.7
—
—
—
0
0
10
47
2.14
1.34
2.9
2.2
32.8
194.6
ug/l
—
10
40
9
42
2.15
1.34
1.2
1.1
—
—
—
0
0
21
129
1.64
1.30
1.9
1.3
—
—
—
0
0
963
9395
1.22
1.30
4.8
4.1
4.9
4.9
mmol/l
0.62
917
8885
8
34
2.36
1.29
1.0
1.3
—
—
—
0
0
8
34
2.36
1.29
1.0
1.3
—
—
—
0
0
8
159
0.50
1.25
2.4
1.7
—
—
—
0
0
6
25
2.41
1.24
2.3
3.5
—
—
—
0
0
25
164
1.54
1.21
3.0
2.5
169.3
118.6
ug/min
0.17
15
107
974
9524
1.22
1.21
5.2
4.5
2.9
2.9
mmol/l
0.75
915
8948
8
39
2.06
1.15
1.3
1.8
—
—
—
0
0
8
39
2.06
1.15
1.3
1.8
—
—
—
0
0
8
39
2.06
1.15
1.6
1.0
—
—
—
0
0
8
39
2.06
1.15
1.3
1.8
—
—
—
0
0
8
39
2.06
1.15
1.3
1.8
—
—
—
0
0
5
20
2.51
1.15
1.2
1.2
—
—
—
0
0
226
2012
1.16
1.14
1.4
1.3
5.4
10.2
u/ml
0.96
88
828
1057
10448
1.44
1.13
25.4
17.5
4.4
4.4
e12/l
1.35
1038
10229
32
225
1.44
1.13
2.4
1.4
8.6
13.7
e6/l
0.37
24
169
1057
10449
1.43
1.12
25.4
17.6
6.6
6.6
e9/l
0.44
1040
10230
7
32
2.19
1.08
1.1
1.4
—
—
—
0
0
1057
10453
1.42
1.07
25.5
17.6
132.4
133.0
g/l
0.97
1051
10350
1056
10442
1.41
1.06
25.5
17.6
267.9
267.6
e9/l
0.05
1042
10249
7
33
2.13
1.05
1.3
1.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
180
1.46
1.01
5.6
2.8
0.3
0.4
u/ml
0.53
17
98
49
379
1.31
1.00
1.6
1.6
314.5
315.3
mu/l
0.01
42
335
713
6853
1.12
0.99
3.4
3.3
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
23
157
1.48
0.96
1.2
1.1
132.3
123.9
%
0.60
23
147
40
303
1.33
0.95
2.1
2.0
2.8
4.8
iu/l
2.05
18
124
9
51
1.77
0.94
1.1
1.0
88.8
93.5
%
—
9
44
14
85
1.66
0.94
1.1
1.1
—
—
—
0
0
6
27
2.23
0.93
1.0
1.3
—
—
—
0
0
10
55
1.83
0.92
1.0
1.1
—
—
—
0
0
36
270
1.34
0.91
1.3
2.0
3.2
3.1
g/l
0.30
31
221
13
78
1.67
0.91
1.5
1.3
1.1
1.9
nmol/l
0.79
13
65
13
78
1.67
0.91
1.1
1.0
—
—
—
0
0
6
28
2.15
0.91
1.0
1.3
188.5
360.0
pmol/l
—
6
22
259
2368
1.12
0.88
5.1
3.9
0.0
0.0
estimate
0.80
78
844
25
346
0.72
0.88
2.0
1.7
—
—
—
0
0
17
111
1.54
0.88
1.6
1.4
—
—
—
0
0
953
9346
1.16
0.87
4.7
4.1
1.6
1.6
mmol/l
1.19
896
8796
17
112
1.53
0.85
1.6
1.4
—
—
—
0
0
17
112
1.53
0.85
1.6
1.4
—
—
—
0
0
42
328
1.29
0.83
1.7
1.6
—
—
—
0
0
14
89
1.58
0.81
1.4
1.1
—
42.7
—
0
6
14
89
1.58
0.81
1.4
1.2
—
74.8
—
0
9
37
285
1.31
0.81
1.3
2.0
7.6
7.5
g/l
0.11
31
230
37
285
1.31
0.81
1.3
2.0
3.4
3.7
g/l
0.93
31
217
37
285
1.31
0.81
1.3
2.0
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
24
0.00
0.79
0.0
1.1
—
84.3
—
0
6
11
66
1.67
0.79
4.4
3.4
—
—
—
0
0
927
9101
1.13
0.70
4.8
4.1
5.9
5.7
mmol/l
2.08
869
8486
5
26
1.93
0.70
1.0
1.0
—
—
—
0
0
68
575
1.19
0.69
1.1
1.0
—
—
—
0
0
5
27
1.86
0.68
2.0
1.3
—
—
—
0
0
23
170
1.36
0.68
1.0
1.1
—
—
—
0
0
15
104
1.45
0.62
1.4
1.7
62.6
51.0
%
—
10
62
20
147
1.37
0.62
2.7
2.2
15.6
16.4
%
0.53
14
71
10
63
1.59
0.62
1.2
1.6
—
—
—
0
0
10
63
1.59
0.62
1.2
1.6
—
—
—
0
0
10
63
1.59
0.62
1.2
1.6
—
—
—
0
0
8
50
1.60
0.61
1.5
1.2
—
—
—
0
0
22
165
1.34
0.60
1.3
1.1
4.0
1.7
u/ml
—
5
50
112
1001
1.13
0.59
1.3
1.3
32.5
33.6
iu/l
0.12
90
872
16
114
1.41
0.59
1.7
1.4
—
—
—
0
0
16
114
1.41
0.59
1.1
1.1
96.3
100.8
%
0.27
16
109
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
8
54
1.48
0.57
1.3
1.8
34.2
25.0
ug/l
—
8
54
12
81
1.49
0.57
1.8
1.7
—
—
—
0
0
16
115
1.40
0.56
1.7
1.4
—
—
—
0
0
16
115
1.40
0.56
1.7
1.4
—
—
—
0
0
11
73
1.51
0.56
1.8
1.8
—
—
—
0
0
198
1835
1.10
0.55
1.6
1.6
498.9
28207200.9
pmol/l
1.76
175
1567
31
383
0.80
0.54
1.3
1.5
—
—
—
0
0
8
126
0.63
0.54
1.3
1.5
—
—
—
0
0
17
127
1.34
0.49
1.8
1.6
—
—
—
0
0
7
45
1.56
0.49
1.0
1.3
—
—
—
0
0
7
49
1.43
0.46
5.0
3.0
474.9
1088.7
u/ml
—
7
49
34
283
1.21
0.45
1.2
1.2
—
—
—
0
0
24
192
1.26
0.45
3.4
3.4
4.0
4.2
e9/l
0.22
24
192
7
50
1.40
0.45
1.0
1.1
—
—
—
0
0
37
311
1.20
0.45
1.4
1.3
—
—
—
0
0
85
764
1.12
0.44
2.4
2.4
7.9
22.5
au/ml
—
5
56
11
78
1.41
0.43
1.3
1.1
—
—
—
0
0
11
78
1.41
0.43
1.3
1.1
—
—
—
0
0
34
285
1.20
0.43
2.2
1.8
—
—
—
0
0
32
267
1.20
0.42
2.9
2.8
49.5
676.3
u/ml
0.67
26
233
22
176
1.26
0.42
1.7
1.6
—
—
—
0
0
22
176
1.26
0.42
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
11
79
1.40
0.41
1.3
1.1
—
—
—
0
0
11
79
1.40
0.41
1.3
1.1
—
—
—
0
0
11
79
1.40
0.41
1.3
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
318.9
—
0
11
38
442
0.85
0.39
2.0
1.8
3.8
2.8
mg/l
0.22
25
305
46
400
1.16
0.39
1.3
1.3
169.3
241.1
miu/ml
0.71
20
203
24
196
1.23
0.39
3.6
3.8
57.4
58.1
%
0.10
24
196
9
66
1.37
0.38
1.6
1.8
—
—
—
0
0
34
289
1.18
0.38
1.1
1.1
—
—
—
0
0
34
289
1.18
0.38
1.7
1.6
0.0
0.1
iu/ml
0.71
11
41
21
170
1.24
0.37
1.7
1.6
—
—
—
0
0
18
144
1.25
0.35
1.2
1.2
—
—
—
0
0
26
218
1.20
0.34
1.5
1.3
—
—
—
0
0
16
127
1.26
0.33
1.3
1.2
—
—
—
0
0
6
46
1.31
0.33
2.5
2.3
—
—
—
0
0
16
128
1.25
0.32
1.0
1.1
—
—
—
0
0
81
745
1.09
0.30
1.4
1.3
193.8
176.1
u/ml
0.09
76
698
7
54
1.30
0.30
2.3
1.4
—
—
—
0
0
11
84
1.31
0.30
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
1.3
1.8
—
—
—
0
0
20
167
1.20
0.28
1.3
1.2
2.1
4.2
u/ml
—
10
57
10
76
1.32
0.28
1.0
1.2
—
—
—
0
0
8
62
1.29
0.28
2.1
1.5
1.4
1.4
nmol/l
—
8
56
11
139
0.79
0.27
1.0
1.1
96.6
3951.4
iu/ml
—
5
32
95
887
1.08
0.26
1.2
1.2
172.9
164.1
iu/ml
0.07
33
372
87
810
1.08
0.26
3.5
2.9
—
—
—
0
0
11
86
1.28
0.26
1.7
2.0
34.5
31.5
pg
1.62
11
86
15
181
0.83
0.25
1.3
1.5
—
—
—
0
0
11
87
1.27
0.24
2.0
1.4
0.9
1.0
g/l
0.11
11
87
9
77
1.17
0.24
2.2
1.5
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
10
124
0.80
0.21
1.0
1.0
—
0.2
—
0
26
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
5.8
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
57
613
0.93
0.20
1.6
1.5
—
—
—
0
0
108
1027
1.06
0.19
6.7
5.5
—
—
—
0
0
11
90
1.22
0.19
2.4
2.2
4.2
3.9
mmol/l
1.08
11
90
11
90
1.22
0.19
2.4
2.2
103.5
105.8
mmol/l
1.14
11
90
11
90
1.22
0.19
1.0
1.0
—
—
—
0
0
7
58
1.21
0.18
1.3
1.9
—
—
—
0
0
13
110
1.18
0.17
1.0
1.0
—
—
—
0
0
7
63
1.11
0.17
15.6
11.1
0.8
0.7
mmol/l
—
7
55
8
70
1.14
0.16
1.8
1.6
14.4
19.2
nmol/l
—
8
65
8
96
0.83
0.13
1.1
1.4
—
—
—
0
0
22
242
0.91
0.13
1.3
1.5
—
—
—
0
0
21
227
0.92
0.09
1.3
1.4
—
—
—
0
0
21
227
0.92
0.09
1.3
1.4
—
—
—
0
0
6
54
1.11
0.09
1.2
1.6
—
—
—
0
0
21
226
0.93
0.08
1.3
1.4
—
—
—
0
0
21
226
0.93
0.08
1.3
1.4
—
—
—
0
0
29
273
1.06
0.08
4.8
3.8
18.6
28.7
u/ml
0.91
29
264
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
6
71
0.84
0.07
2.7
2.5
—
—
—
0
0
25
264
0.95
0.06
1.4
1.4
—
—
—
0
0
10
111
0.90
0.06
1.1
1.4
—
—
—
0
0
19
178
1.07
0.05
4.5
3.6
16.7
19.6
mg/l
0.24
12
111
11
101
1.09
0.04
2.0
1.5
—
—
—
0
0
17
180
0.94
0.04
1.0
1.1
—
—
—
0
0
13
121
1.08
0.03
1.5
1.7
4.3
4.7
ug/l
—
8
97
800
8017
0.99
0.03
22.2
14.1
13.7
13.6
%
0.20
790
7867
873
8743
0.99
0.02
18.7
12.6
38.8
39.4
%
1.45
690
6807
17
177
0.96
0.01
1.1
1.0
6.5
2.3
u/ml
—
9
90
12
114
1.05
0.00
2.7
5.1
9.7
51.1
u/ml
—
5
32
13
129
1.01
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
5
56
0.89
0.00
1.4
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
7.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
13.1
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
8.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
9
93
0.97
0.00
1.6
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
11
110
1.00
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
6
65
0.92
0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_VULVAL_LSIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_VULVAL_LSIL | 0.98 [0.83, 1.16] | 0.81 |
| Birth year | 0.998 [0.99, 1.01] | 0.701 |
During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 1884 females with N14_VULVAL_LSIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_VULVAL_LSIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.081% | No data |
| 5 | 0.557% | No data |
| 10 | 1.448% | No data |
| 15 | 2.86% | No data |
| 20 | 5.428% | No data |
Relationships between endpoints
↥Index endpoint: N14_VULVAL_LSIL – LSIL lesion of the vulva
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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