LSIL lesion of the vulva

N14_VULVAL_LSIL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N90.0
  • Hospital discharge: ICD-9 0781C
  • Cause of death: ICD-10 N90.0
  • Cause of death: ICD-9 0781C

2 out of 7 registries used, show all original rules.

1105

4. Check minimum number of events

None

1105

5. Include endpoints

None

1105

6. Filter based on genotype QC (FinnGen only)

1067

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6816 6816 -
Only index persons 6423 6423 -
Unadjusted period prevalence (%)
Whole population 0.20 0.20 -
Only index persons 0.24 0.24 -
Median age at first event (years)
Whole population - 32.01 -
Only index persons - 31.60 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1067 1067 -
Unadjusted period prevalence (%) 0.38 0.38 -
Median age at first event (years) 33.05 33.05 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1105
Matched controls
11050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
25.9
307.7
316
168
N90.0
ICD-10 Finland
Mild vulvar dysplasia
+∞
307.7
457
*
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
+∞
307.7
650
*
ULA02
NOMESCO Finland
Kolposcopy
7.1
219.4
462
1011
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
271.9
182.5
182
8
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
207.5
157.3
160
9
8326
FHL
Batch conization
60.9
132.4
74
13
LEB00
NOMESCO Finland
Biopsy of vagina
12.1
118.3
124
114
8411
FHL
Local change laser, coagulation, biopsy or removal
183.1
111.6
115
7
N89.0
ICD-10 Finland
Mild vaginal dysplasia
33.4
111.6
72
23
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.3
108.7
393
1265
A63.0
ICD-10 Finland
Anogenital (venereal) warts
7.6
91.4
139
206
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
16.1
89.5
78
52
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
40.2
81.7
50
13
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
4.3
75.9
232
644
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
21.0
73.5
56
28
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.5
66.9
294
1041
D06BB04
ATC
podophyllotoxin; topical
5.1
62.7
142
308
D06BB10
ATC
imiquimod; topical
5.4
57.1
121
247
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
5.1
51.8
115
244
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
16.3
51.4
44
28
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
84.3
50.4
56
7
N87.0
ICD-10 Finland
Mild cervical dysplasia
5.3
50.2
107
219
6221A
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI LEVIS]
191.2
36.0
37
*
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
11.6
34.6
36
32
1390
FHL
Colposcopy
175.2
32.9
34
*
LDA10
NOMESCO Finland
Curettage of cervix uteri
3.3
31.1
125
407
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
3.3
27.6
114
377
8111
FHL
Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)
63.7
27.1
31
5
6221B
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI MODERATA]
53.1
26.3
31
6
8113
FHL
Fractional scraping
3.1
25.9
116
402
LFC00
NOMESCO Finland
Partial excision of vulva
21.2
22.7
33
16
D07AD01
ATC
clobetasol; topical
2.1
22.3
245
1298
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
6.8
21.8
34
51
J02AC01
ATC
fluconazole; systemic
1.8
20.4
646
4819
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
20.1
501
3473
7950A
ICD-9 Finland
Nonspecific abnormal histological and immunological findings, Nonspecific abnormal Papanicolaou smear of cervix
39.1
18.6
23
6
127
Kela drug reimbursment
Transplant complication
7.3
18.3
27
38
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
19.7
18.2
27
14
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
33.5
18.0
23
7
6350C
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,SOSIAALISET SYYT]
2.5
18.0
121
518
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
4.6
17.4
41
91
8339
FHL
Other measure in this category
19.6
16.9
25
13
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
4.1
16.1
44
110
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.5
15.8
39
90
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
15.5
334
2181
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.6
15.0
24
37
A10AB01
ATC
insulin (human); parenteral
3.5
14.8
51
150
N03AX16
ATC
[U] pregabalin
1.8
14.7
294
1874
A10AA02, ,
ATC
3.6
13.7
45
128
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.7
13.4
42
116
A10AA01, ,
ATC
3.7
13.2
42
117
P01AB01
ATC
metronidazole; oral, rectal
1.6
13.0
533
4066
G01AF01
ATC
metronidazole; vaginal
1.9
12.9
189
1092
A10AE04
ATC
insulin glargine; parenteral
2.4
12.3
91
406
L29.2
ICD-10 Finland
Pruritus vulvae
3.7
12.2
39
109
A11CC03
ATC
alfacalcidol; systemic
4.6
12.2
29
65
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
3.0
12.1
53
181
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
27.0
12.1
16
6
G01AF04
ATC
miconazole; vaginal
2.2
12.0
106
510
L04AA06
ATC
mycophenolic acid; systemic
4.5
11.7
28
63
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
16.6
11.7
18
11
8112
FHL
Scraping the cervix
30.4
11.7
15
5
G01AA10
ATC
clindamycin; vaginal
1.7
11.4
270
1788
N87.1
ICD-10 Finland
Moderate cervical dysplasia
3.0
11.1
49
168
A10AC01
ATC
insulin (human); parenteral
2.3
11.0
81
360
N90.4
ICD-10 Finland
Leukoplakia of vulva
9.3
11.0
22
24
J01FF01
ATC
clindamycin; systemic
1.6
10.9
303
2085
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.9
10.9
51
181
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.8
10.9
178
1060
6221C
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI GRAVIS]
15.7
10.8
17
11
L04AD02
ATC
tacrolimus; systemic
9.0
10.8
22
25
A02BC02
ATC
pantoprazole; systemic
1.6
10.7
759
6434
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
10.5
499
3875
TK800
NOMESCO Finland
Hemodialysis
5.2
10.3
21
41
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.6
10.3
287
1974
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.8
10.1
51
189
8511
FHL
Cervical dilation and drainage with suction
2.3
10.0
77
349
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.0
446
3406
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
40.4
10.0
12
*
UJF32
NOMESCO Finland
Coloscopy
1.6
9.8
264
1796
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
26.3
9.8
13
5
8513
FHL
Softening of cervix with abortifacient or laminars and associated surgical emptying of the uterus
2.6
9.7
55
217
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.8
9.6
21
44
7020X
ICD-9 Finland
Other dermatoses, Actinic keratosis[DERMATOSES PRAECANCEROSAE ALIAE]
100.9
9.4
10
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
9.3
63
270
E0000UV, ,
ATC
1.5
9.3
469
3658
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
9.3
316
2268
Z25.1
ICD-10 Finland
Need for immunization against influenza
2.4
9.1
61
260
J01MA02
ATC
ciprofloxacin; systemic
1.5
9.1
379
2839
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
15.7
9.0
14
9
ZXA05
NOMESCO Finland
Left side
1.6
9.0
248
1696
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
8.9
424
3259
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
24.2
8.9
12
5
A10AB04
ATC
insulin lispro; parenteral
2.9
8.8
42
151
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
8.8
86
430
H04AA01
ATC
glucagon; nasal, parenteral
3.5
8.7
29
84
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.6
426
3299
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
3.9
8.5
25
66
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.5
8.5
29
85
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.8
8.5
120
683
R4110
NOMESCO Finland
Physiotherapy
1.5
8.4
291
2088
C03CA01
ATC
furosemide; systemic
1.6
8.4
219
1473
Z01.2
ICD-10 Finland
Dental examination
1.4
8.3
522
4219
J01MA12
ATC
levofloxacin; systemic
1.7
8.3
176
1124
N01BB02
ATC
lidocaine; parenteral
4.3
8.2
21
50
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
8.2
80
401
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
8.1
292
2112
H3603, E103,
ICD-10 Finland
6.9
8.1
19
28
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
22.2
8.0
11
5
Z94.0
ICD-10 Finland
Kidney transplant status
7.3
8.0
18
25
A10AB05
ATC
insulin aspart; parenteral
2.2
7.9
69
330
N76.6
ICD-10 Finland
Ulceration of vulva
4.5
7.9
19
43
Z2221
NOMESCO Finland
Medical doctor
1.5
7.9
313
2309
62191
ICD-8 Finland
Other diseases of cervix, Dysplasia portionis uteri
8.5
7.8
16
19
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
2.8
7.8
38
139
Z29.8
ICD-10 Finland
Other specified prophylactic measures
2.7
7.8
42
162
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
45.3
7.7
9
*
6230A
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE LEVIS]
45.3
7.7
9
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
7.7
141
865
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
7.6
384
2966
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
3.2
7.6
30
97
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
7.5
185
1225
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.5
268
1930
N06AX12
ATC
bupropion; oral
1.9
7.5
89
477
T89
ICPC
Diabetes insulin dependent
2.5
7.5
46
189
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.7
7.5
23
63
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
7.4
288
2111
TLC02
NOMESCO Finland
Simple extraction of IUD
2.0
7.3
81
424
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.8
7.3
105
600
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
9.4
7.3
14
15
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
9.4
7.3
14
15
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.4
7.2
680
5852
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
7.2
339
2580
L04AA01
ATC
[U] ciclosporin
4.0
7.2
20
51
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
4.0
7.2
20
51
J01DA01
ATC
[U] cefalexin
1.4
7.1
710
6166
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.8
7.1
110
643
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.9
7.1
32
112
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
7.1
71
359
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
5.9
6.9
18
31
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
6.7
6.8
16
24
N30.0
ICD-10 Finland
Acute cystitis
1.5
6.8
202
1396
ZXD05
NOMESCO Finland
Urgent procedure
1.4
6.7
316
2398
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.7
192
1317
A02BC05
ATC
esomeprazole; systemic
1.4
6.6
450
3643
ZX120
NOMESCO Finland
Intravenous
1.8
6.6
101
589
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.5
6.6
22
64
M05BA07
ATC
risedronic acid; oral
2.6
6.6
37
146
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
6.6
205
1432
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
1.7
6.5
128
800
Z3231
NOMESCO Finland
Registered nurse
1.5
6.5
267
1972
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.3
6.5
46
202
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
6.5
119
730
G01AF02
ATC
clotrimazole; vaginal
2.0
6.5
71
371
A12AA04
ATC
calcium carbonate; oral
5.4
6.5
18
34
J01DB01
ATC
cefalexin; oral
1.5
6.4
901
8241
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
6.4
45
198
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.3
207
1460
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
6.3
6
*
R32
ICD-10 Finland
Unspecified urinary incontinence
2.6
6.2
35
138
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.2
428
3462
A46
ICD-10 Finland
Erysipelas
1.7
6.2
111
676
S20
ICPC
Corn/callosity
3.7
6.2
19
52
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.2
103
616
K02.1
ICD-10 Finland
Caries of dentine
1.4
6.2
646
5589
E000006, ,
ATC
1.9
6.2
82
458
XCK10
NOMESCO Finland
Photography of fundus of eye
1.9
6.1
81
451
ZXA00
NOMESCO Finland
Right side
1.5
6.1
256
1896
TQW99
NOMESCO Finland
Other minor procedure on skin
2.2
6.1
50
234
X86
ICPC
Abnormal cervix smear
3.8
6.1
18
48
G01AF05
ATC
econazole; vaginal
1.6
6.1
139
904
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.0
6.0
60
303
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.0
122
769
N02AA05
ATC
oxycodone; systemic
1.6
6.0
140
914

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
160
209
8.78
117.96
2.9
1.8
—
—
—
0
0
615
4296
1.97
26.49
3.3
2.0
—
—
—
0
0
229
1230
2.09
19.88
3.3
2.5
4.69
4.80
e6/l
0.05
137
600
416
3024
1.60
12.22
5.4
3.3
95.54
71.52
e6/l
0.49
302
2031
220
1356
1.78
12.09
3.1
2.4
1.15
1.20
e6/l
0.07
128
726
350
2464
1.62
11.62
4.6
2.8
53.92
93.03
e6/l
0.55
270
1843
388
2802
1.59
11.57
2.7
2.1
—
—
—
0
0
165
954
1.86
11.13
2.3
1.6
—
—
—
0
0
349
2483
1.59
10.97
9.6
6.3
—
—
—
0
0
164
954
1.84
10.84
9.7
4.5
1.07
1.03
mmol/l
0.82
156
875
483
3709
1.54
10.77
6.3
4.0
35.84
36.32
g/l
1.23
466
3470
320
2263
1.58
10.19
4.4
2.7
0.23
0.42
e6/l
2.43
248
1676
456
3489
1.52
10.17
2.0
1.9
101.29
99.24
pmol/l
0.37
238
1742
320
2273
1.57
9.96
4.2
2.6
—
—
—
0
0
113
597
1.99
9.96
1.3
1.2
—
—
—
0
0
318
2289
1.55
9.21
5.2
3.2
97.38
98.22
%
0.27
309
2217
105
556
1.98
9.19
12.5
6.4
8.60
8.17
mmol/l
0.33
100
533
552
4459
1.48
9.11
7.8
5.9
—
—
—
0
0
297
2111
1.56
9.09
2.5
2.1
—
—
—
0
0
235
1584
1.61
9.01
4.5
2.5
481.39
506.05
mosm/kgh2o
0.99
208
1367
198
1282
1.66
8.90
3.3
2.1
13.21
13.63
umol/l
0.37
190
1194
210
1391
1.63
8.62
1.2
1.2
—
—
—
0
0
491
3911
1.46
8.52
7.9
5.0
1.22
1.22
mmol/l
0.67
464
3589
656
5523
1.46
8.49
11.9
8.6
3.90
3.89
e9/l
0.01
591
4868
181
1159
1.67
8.47
3.4
2.1
2.37
2.43
g/l
1.04
169
1079
167
1049
1.70
8.40
3.7
2.2
21.46
22.88
%
0.84
153
893
591
4886
1.45
8.36
8.0
5.5
1.95
1.95
e9/l
0.00
553
4376
138
826
1.77
8.24
1.5
1.4
—
—
—
0
0
576
4752
1.44
8.17
7.9
5.5
0.55
0.53
e9/l
0.98
526
4162
199
1324
1.61
7.98
4.3
2.9
0.81
0.82
mmol/l
0.58
193
1242
542
4443
1.43
7.83
8.1
5.8
8.15
8.08
%
0.23
511
4176
574
4760
1.43
7.75
8.0
5.5
0.04
0.04
e9/l
0.03
525
4161
555
4576
1.43
7.73
8.0
5.6
28.95
29.19
%
0.21
527
4312
539
4422
1.43
7.71
7.9
5.5
2.88
2.75
%
0.76
508
4149
592
4949
1.42
7.57
8.2
5.7
0.19
0.18
e9/l
0.85
554
4390
370
2845
1.45
7.48
3.5
2.8
—
—
—
0
0
188
1257
1.60
7.35
1.3
1.2
—
—
—
0
0
263
1901
1.50
7.24
1.6
1.5
23.47
21.97
nmol/l
0.35
238
1649
811
7213
1.47
7.17
4.8
4.0
12.22
11.24
mm/h
1.23
770
6739
518
4261
1.41
7.09
8.1
5.6
0.69
0.70
%
0.18
489
3973
545
4523
1.40
7.08
7.9
5.4
56.37
56.52
%
0.11
518
4250
14
16
8.85
7.06
1.6
1.3
—
—
—
0
0
367
2846
1.43
6.99
2.8
2.3
52.82
58.17
u/l
2.06
350
2628
20
53
3.82
6.82
3.3
3.1
80.11
9.53
mg/l
—
10
31
527
4373
1.39
6.73
8.7
5.7
1.22
1.22
mmol/l
1.44
483
3715
157
1034
1.60
6.51
1.6
1.5
—
—
—
0
0
168
1131
1.57
6.35
2.7
1.9
—
—
—
0
0
318
2438
1.43
6.34
4.4
2.9
6.44
6.86
mmol/l
1.15
263
2093
562
4745
1.38
6.31
7.0
5.5
8.99
9.94
umol/l
2.95
553
4506
398
3177
1.40
6.29
3.9
2.8
33.93
29.82
u/l
0.53
384
3037
38
157
2.47
6.16
1.7
1.3
—
—
—
0
0
723
6372
1.39
6.15
5.5
4.1
—
—
—
0
0
122
767
1.66
6.08
2.6
3.4
4.30
4.49
pmol/l
1.16
105
682
296
2255
1.43
6.08
4.3
3.1
55.25
374.24
mg/l
2.64
189
1291
256
1907
1.45
5.92
5.1
3.7
—
—
—
0
0
260
1944
1.44
5.89
2.9
2.7
959.56
813.63
ng/l
0.33
223
1627
305
2350
1.41
5.85
5.1
3.6
11.28
6.92
mg/mmol
0.68
193
1341
271
2046
1.43
5.82
1.5
1.5
2.10
2.18
g/l
0.38
160
1282
581
4974
1.35
5.76
5.9
4.1
6.66
6.46
mmol/l
1.04
553
4631
55
274
2.06
5.76
1.5
1.4
323.40
311.71
ug/g
0.14
35
153
150
1006
1.57
5.75
2.9
2.3
5.26
5.90
umol/l
0.39
131
862
54
269
2.06
5.66
2.9
2.1
1.35
1.50
g/l
0.58
47
239
507
4259
1.35
5.65
2.9
2.2
78.10
78.04
nmol/l
0.02
464
3904
15
28
5.42
5.54
2.7
2.6
—
—
—
0
0
221
1621
1.45
5.52
2.7
2.6
2.44
2.44
mmol/l
0.00
182
1440
540
4593
1.34
5.49
5.9
4.8
0.00
0.00
estimate
0.50
82
859
544
4641
1.34
5.38
4.4
3.6
0.00
0.01
estimate
1.06
78
846
110
696
1.64
5.36
3.1
3.0
9.81
10.36
g/l
0.70
104
649
34
143
2.42
5.34
1.6
1.3
110.60
123.68
u/ml
—
5
29
183
1302
1.49
5.32
2.0
2.2
175.35
99.82
ug/g
1.02
147
1025
230
1718
1.43
5.18
4.0
2.3
6.18
8.10
e6/l
1.38
206
1546
280
2168
1.39
5.13
2.3
2.1
3.11
2.92
mg/l
0.44
256
1853
796
7214
1.37
5.13
9.5
6.8
74.59
75.82
u/l
0.55
756
6819
208
1529
1.44
5.11
1.5
1.3
541.48
592.43
titre
0.23
54
333
73
421
1.79
4.98
2.3
1.8
—
—
—
0
0
54
283
1.95
4.95
1.2
1.2
—
—
—
0
0
534
4580
1.32
4.93
4.4
3.6
0.00
0.00
estimate
-0.00
91
904
269
2084
1.38
4.88
4.4
3.5
—
—
—
0
0
113
738
1.59
4.86
3.3
2.7
1.83
1.82
%
0.00
103
655
1006
9544
1.60
4.82
17.6
11.7
18.89
19.41
mg/l
0.21
829
7354
89
550
1.67
4.77
10.2
7.1
—
—
—
0
0
424
3534
1.32
4.74
12.5
10.4
1.17
1.13
inr
0.46
108
1098
103
662
1.61
4.73
1.4
1.3
—
—
—
0
0
35
158
2.25
4.73
1.4
1.2
344.34
283.32
u/ml
0.55
28
98
32
140
2.32
4.65
2.0
1.5
—
—
—
0
0
87
539
1.67
4.62
2.2
2.7
200.22
145.56
ng/l
0.48
76
483
194
1435
1.43
4.58
1.8
1.7
1226.67
1197.72
nmol/l
0.16
165
1088
201
1498
1.42
4.55
3.9
3.4
101.24
334.65
ng/l
2.19
123
975
105
687
1.58
4.49
5.3
3.1
103.63
73.86
ng/l
1.51
95
613
530
4582
1.30
4.46
3.4
2.8
98.22
81.49
ug/l
1.21
510
4313
315
2539
1.34
4.38
1.7
1.6
1.39
1.36
mmol/l
0.29
275
2193
10
16
6.30
4.30
6.0
4.6
—
—
—
0
0
48
256
1.91
4.22
2.3
3.0
0.34
0.30
g/l
0.12
20
77
497
4289
1.29
4.14
2.8
2.3
—
—
—
0
0
69
416
1.70
4.08
2.9
3.1
7.41
7.41
ph
—
9
61
56
318
1.80
4.07
1.2
1.2
—
—
—
0
0
70
425
1.69
4.04
1.1
1.2
—
—
—
0
0
975
9253
1.46
3.95
5.9
5.2
1.78
2.13
mu/l
0.91
916
8687
20
76
2.66
3.91
6.1
2.5
—
—
—
0
0
47
256
1.87
3.90
6.1
2.8
—
—
—
0
0
53
300
1.81
3.90
2.6
3.2
—
—
—
0
0
302
2461
1.31
3.82
1.4
1.3
2.19
1.65
u/ml
0.18
89
670
82
528
1.60
3.78
2.7
2.8
67.98
74.63
e9/l
0.79
56
390
39
202
1.96
3.76
1.2
1.3
—
9.32
—
0
5
148
1080
1.43
3.76
1.6
1.3
—
—
—
0
0
21
85
2.50
3.64
1.1
1.3
—
—
—
0
0
16
56
2.88
3.64
2.8
2.1
—
—
—
0
0
55
323
1.74
3.60
7.2
3.2
24.16
24.37
mmol/l
0.18
55
313
157
1167
1.40
3.60
2.9
1.9
28.49
29.43
s
1.37
152
1131
90
602
1.54
3.53
2.9
2.6
—
—
—
0
0
94
635
1.52
3.53
6.1
3.0
2.10
2.21
mmol/l
0.10
80
529
119
844
1.46
3.52
2.3
2.2
32.11
37.36
u/l
0.75
101
707
377
3194
1.27
3.48
4.0
3.4
2.35
2.36
mmol/l
0.24
337
2880
210
1648
1.34
3.43
1.8
1.7
—
—
—
0
0
22
94
2.37
3.42
2.3
2.6
—
—
—
0
0
310
2571
1.29
3.38
2.2
2.1
119.95
159.42
u/l
0.81
299
2432
293
2413
1.29
3.38
3.8
3.2
—
—
—
0
0
9
18
5.03
3.37
1.0
1.0
—
—
—
0
0
314
2622
1.28
3.23
6.7
3.5
7.39
7.40
ph
0.60
43
509
13
44
2.98
3.14
3.0
3.1
40115.38
38519.27
ug/l
0.20
13
44
78
520
1.54
3.13
5.0
2.5
4.79
4.60
kpa
0.31
72
501
723
6650
1.25
3.13
3.3
2.9
42.57
39.06
u/l
0.61
695
6298
127
937
1.40
3.05
1.9
2.0
385.34
371.84
nmol/l
0.30
119
869
174
1353
1.34
3.02
1.6
1.6
—
—
—
0
0
1048
10168
1.59
3.00
12.7
9.5
23.75
23.98
u/l
0.22
1027
9894
425
3705
1.24
2.96
3.9
3.3
5.84
5.90
ph
0.15
35
345
43
250
1.75
2.96
3.0
2.3
—
—
—
0
0
71
470
1.55
2.96
1.4
1.3
0.27
0.99
u/ml
—
10
44
475
4194
1.23
2.93
11.5
8.3
0.00
0.00
e9/l
0.13
414
3432
139
1052
1.37
2.87
1.3
1.3
—
—
—
0
0
47
286
1.67
2.77
10.4
7.3
—
—
—
0
0
867
8188
1.27
2.77
5.0
4.4
14.68
14.50
pmol/l
1.42
814
7648
5
6
8.36
2.75
4.8
6.7
4.00
6.92
mmol/l
—
5
6
11
34
3.26
2.73
1.9
1.4
—
—
—
0
0
252
2091
1.27
2.68
1.4
1.3
25.17
28.09
iu/ml
0.21
69
712
8
19
4.23
2.68
1.1
1.2
—
—
—
0
0
9
25
3.62
2.57
2.3
1.5
—
—
—
0
0
51
324
1.60
2.56
3.5
1.9
0.21
0.23
g/l
1.24
51
305
79
553
1.46
2.56
1.2
1.1
—
164.58
—
0
12
115
862
1.37
2.54
1.2
1.2
—
—
—
0
0
23
115
2.02
2.52
3.1
2.4
—
—
—
0
0
268
2257
1.25
2.50
2.9
2.2
2808.14
4076.57
umol/l
0.29
240
2009
234
1952
1.25
2.37
4.6
3.9
1.01
1.02
kg/l
0.62
34
279
12
46
2.63
2.36
8.2
2.7
—
—
—
0
0
271
2305
1.23
2.30
2.0
1.7
0.95
0.81
mg/l
0.51
205
1732
955
9182
1.30
2.28
4.2
3.7
1.30
1.24
mmol/l
1.83
900
8594
64
441
1.48
2.27
1.8
1.9
2282.61
3397.41
u/l
0.19
22
164
996
9642
1.33
2.17
18.6
12.3
139.60
139.73
mmol/l
0.98
983
9418
51
339
1.53
2.15
3.5
1.8
1.09
1.20
g/l
2.15
51
317
5
10
5.02
2.07
1.0
1.0
5.68
5.74
nmol/l
—
5
10
997
9667
1.32
2.03
19.2
12.4
3.94
3.92
mmol/l
1.10
983
9418
350
3087
1.20
2.02
3.7
3.0
22.53
40.42
ng/l
0.66
203
1742
11
44
2.52
2.01
1.7
1.3
—
—
—
0
0
52
747
0.68
1.98
1.4
1.4
—
—
—
0
0
47
314
1.52
1.96
1.3
1.3
10.15
9.98
u/ml
—
6
62
28
164
1.73
1.96
1.3
1.1
—
—
—
0
0
45
298
1.53
1.95
1.4
1.4
37.18
29.88
u/l
0.70
39
246
11
45
2.46
1.93
1.7
1.3
—
—
—
0
0
73
534
1.39
1.92
1.4
2.3
—
—
—
0
0
109
849
1.31
1.91
3.7
3.7
3.45
15.54
ug/l
1.47
88
663
102
787
1.33
1.91
7.4
7.1
1.28
1.31
mmol/l
0.03
84
628
58
407
1.45
1.91
4.0
3.0
—
—
—
0
0
41
270
1.54
1.84
1.1
1.2
—
—
—
0
0
894
8590
1.21
1.77
6.5
4.9
39.85
38.66
mmol/mol
2.94
842
8072
341
3808
0.85
1.75
2.9
2.6
—
—
—
0
0
15
74
2.04
1.75
1.4
1.4
—
—
—
0
0
20
110
1.83
1.73
1.1
1.5
—
—
—
0
0
81
614
1.34
1.73
1.6
2.7
65.10
67.63
g/l
1.76
73
573
23
134
1.73
1.67
1.1
1.3
—
—
—
0
0
982
9551
1.25
1.58
4.8
4.1
4.88
4.92
mmol/l
0.67
937
9036
5
15
3.34
1.52
2.6
2.3
23.46
24.50
umol/l
—
5
15
6
21
2.87
1.50
1.0
1.0
—
—
—
0
0
13
65
2.01
1.49
1.7
2.2
3.00
2.12
u/field
—
8
34
1076
10612
1.53
1.48
25.3
17.5
39.42
39.71
%
0.91
1048
10074
19
109
1.76
1.47
1.5
1.4
—
—
—
0
0
993
9683
1.25
1.47
5.2
4.5
2.89
2.93
mmol/l
0.67
935
9112
12
59
2.05
1.44
1.0
1.1
—
—
—
0
0
71
547
1.32
1.40
2.2
2.2
4.37
5.06
ug/l
0.23
66
480
9
40
2.26
1.40
1.6
1.2
—
—
—
0
0
23
142
1.63
1.39
1.1
1.3
0.44
0.59
nmol/l
2.88
23
136
117
962
1.24
1.39
1.5
1.4
—
—
—
0
0
233
2050
1.17
1.36
1.4
1.3
5.30
10.18
u/ml
1.00
90
837
23
143
1.62
1.36
1.1
1.3
—
0.50
nmol/l
—
0
6
9
42
2.15
1.34
1.2
1.6
54.11
73.62
nmol/24h
—
9
42
18
105
1.73
1.33
1.4
1.7
56.69
50.97
%
0.22
13
62
23
144
1.61
1.33
1.0
1.0
—
—
—
0
0
1025
10050
1.27
1.30
15.0
10.9
—
—
—
0
0
9
43
2.10
1.30
2.9
3.2
—
—
—
0
0
10
48
2.09
1.28
2.3
3.0
0.16
0.14
e9/l
—
10
48
10
48
2.09
1.28
2.9
2.2
32.81
190.90
ug/l
—
10
41
26
170
1.54
1.27
1.9
1.9
121.70
131.24
g/l
1.40
20
123
87
700
1.26
1.26
2.1
2.6
4.26
4.60
e9/l
0.24
75
592
1076
10631
1.46
1.22
25.3
17.6
6.63
6.56
e9/l
0.39
1058
10409
1076
10631
1.46
1.22
25.2
17.5
91.05
90.79
fl
1.16
1069
10524
51
383
1.35
1.22
1.6
1.6
311.98
315.76
mu/l
0.04
44
339
16
93
1.73
1.21
1.4
1.2
—
63.92
—
0
8
24
156
1.55
1.21
1.0
1.1
—
—
—
0
0
1076
10633
1.46
1.20
25.3
17.5
4.41
4.44
e12/l
1.28
1056
10411
1076
10633
1.46
1.20
25.2
17.4
30.22
30.12
pg
1.01
1069
10525
25
165
1.53
1.18
2.8
2.3
169.34
118.17
ug/min
0.17
15
108
27
182
1.50
1.16
4.7
4.1
—
—
—
0
0
21
134
1.58
1.15
1.1
1.3
—
—
nmol/l
—
0
0
28
191
1.48
1.14
2.1
2.2
—
—
—
0
0
0
36
0.00
1.14
0.0
1.7
—
—
—
0
0
267
2406
1.14
1.13
5.1
3.9
0.00
0.00
estimate
0.80
83
859
1076
10638
1.44
1.13
25.4
17.6
132.44
133.03
g/l
0.90
1070
10532
1075
10627
1.43
1.12
25.4
17.5
267.48
267.41
e9/l
0.01
1061
10431
10
51
1.97
1.11
1.0
1.5
164.20
150.43
mmol/24h
—
10
51
46
347
1.34
1.09
3.3
1.7
21.05
20.63
s
0.32
40
293
7
32
2.19
1.08
1.3
1.2
—
—
—
0
0
32
228
1.42
1.06
2.4
1.4
8.63
13.56
e6/l
0.35
24
171
22
145
1.53
1.06
7.7
2.8
—
—
—
0
0
7
33
2.13
1.05
1.4
1.2
—
—
—
0
0
971
9502
1.18
1.03
4.7
4.1
1.55
1.58
mmol/l
1.35
915
8949
10
53
1.89
1.01
3.0
2.3
10.35
10.83
%
—
10
53
88
731
1.22
1.00
1.3
1.2
—
—
—
0
0
11
61
1.81
0.98
1.1
1.2
—
—
—
0
0
5
23
2.18
0.98
2.2
3.6
56.10
49.91
%
—
5
23
21
140
1.51
0.98
1.0
1.1
—
—
—
0
0
25
174
1.45
0.95
4.8
1.9
—
—
—
0
0
13
77
1.70
0.95
1.5
1.3
1.11
1.63
nmol/l
0.77
13
66
7
37
1.90
0.94
1.3
1.1
—
—
—
0
0
99
1160
0.84
0.92
1.3
1.4
—
—
—
0
0
6
28
2.15
0.91
1.0
1.3
188.50
360.00
pmol/l
—
6
22
15
94
1.60
0.91
2.3
2.3
—
—
—
0
0
102
872
1.19
0.88
3.4
3.6
—
—
—
0
0
946
9265
1.15
0.86
4.8
4.1
5.86
5.74
mmol/l
1.97
887
8635
17
112
1.53
0.85
1.9
1.4
—
—
—
0
0
6
31
1.94
0.84
1.8
2.3
7.17
6.90
%
—
6
31
6
31
1.94
0.84
1.8
2.3
—
—
—
0
0
58
471
1.24
0.84
2.4
2.3
—
—
—
0
0
40
310
1.30
0.83
2.1
2.0
2.81
4.69
iu/l
1.96
18
126
21
146
1.45
0.83
1.5
1.3
—
—
—
0
0
11
65
1.70
0.82
1.0
1.3
—
—
—
0
0
17
113
1.51
0.82
1.1
1.1
—
—
—
0
0
21
147
1.44
0.80
1.1
1.3
—
43.37
—
0
10
10
58
1.73
0.79
1.0
1.1
—
—
—
0
0
15
98
1.54
0.78
2.9
3.0
—
—
—
0
0
74
870
0.84
0.74
1.6
1.8
—
—
—
0
0
675
6524
1.09
0.70
3.9
3.2
—
—
—
0
0
11
69
1.60
0.68
1.2
1.8
—
—
—
0
0
26
196
1.33
0.68
3.4
3.5
4.02
4.15
e9/l
0.15
26
196
79
680
1.17
0.67
5.1
4.1
0.05
1.11
%
0.82
22
160
114
1013
1.14
0.64
1.3
1.3
32.52
33.69
iu/l
0.12
92
880
14
96
1.46
0.61
2.1
1.7
4.13
44.80
u/ml
0.53
14
96
18
130
1.39
0.61
1.6
1.4
—
—
—
0
0
16
113
1.42
0.61
9.5
2.2
64.87
62.12
%
0.23
16
113
26
200
1.31
0.61
3.6
3.8
57.31
58.12
%
0.13
26
200
43
353
1.23
0.61
12.4
10.0
—
—
—
0
0
20
148
1.36
0.60
2.7
2.2
15.64
16.44
%
0.53
14
72
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
77
671
1.16
0.58
1.4
1.4
—
—
—
0
0
8
54
1.48
0.57
1.3
1.8
34.24
25.02
ug/l
—
8
54
82
719
1.15
0.57
4.9
4.1
0.08
0.13
%
0.39
26
199
202
1872
1.10
0.56
1.7
1.6
497.74
38471613.10
pmol/l
2.24
176
1596
10
65
1.54
0.55
1.3
1.2
—
—
—
0
0
30
240
1.26
0.54
1.0
1.1
—
—
—
0
0
21
160
1.32
0.53
1.7
1.7
—
—
—
0
0
274
2579
1.08
0.53
3.8
3.2
—
—
—
0
0
78
686
1.15
0.53
4.0
3.5
—
—
—
0
0
12
83
1.45
0.52
2.2
2.7
—
—
—
0
0
9
64
1.41
0.51
2.0
2.8
—
—
—
0
0
16
118
1.36
0.50
1.0
1.2
—
—
—
0
0
31
254
1.23
0.47
1.3
1.2
—
—
—
0
0
26
209
1.25
0.46
2.5
1.4
—
—
—
0
0
7
49
1.43
0.46
5.0
3.0
474.86
1088.67
u/ml
—
7
49
20
156
1.29
0.45
12.5
3.0
3.17
2.69
mmol/l
0.21
13
106
12
86
1.40
0.44
1.1
1.0
—
—
—
0
0
50
433
1.16
0.44
7.3
5.7
—
—
—
0
0
11
78
1.41
0.43
1.7
1.2
—
—
—
0
0
5
32
1.56
0.42
1.0
1.1
—
8.00
%
—
0
5
84
757
1.12
0.42
4.8
4.0
0.59
1.07
%
1.23
28
236
86
777
1.12
0.41
2.4
2.4
23.70
25.74
au/ml
—
9
75
824
8373
0.94
0.40
22.5
14.9
330.68
330.99
g/l
0.49
817
8313
0
17
0.00
0.40
0.0
1.9
—
—
—
0
0
12
88
1.37
0.40
1.7
2.0
34.75
31.50
pg
1.98
12
88
0
18
0.00
0.40
0.0
3.4
—
—
—
0
0
5
35
1.43
0.39
1.4
2.1
7.82
9.04
mg/l
—
5
28
55
485
1.14
0.39
1.1
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
11
80
1.38
0.38
1.3
1.2
—
—
—
0
0
18
143
1.26
0.37
1.1
1.8
—
—
—
0
0
10
72
1.39
0.37
2.9
2.3
1.90
1.00
g/24h
—
5
37
83
755
1.11
0.37
1.4
1.3
189.58
177.06
u/ml
0.06
78
707
32
272
1.18
0.36
2.9
2.8
49.15
666.72
u/ml
0.67
26
237
46
404
1.14
0.35
1.3
1.3
169.32
239.77
miu/ml
0.69
20
206
16
126
1.27
0.35
2.8
2.7
2.03
1.44
%
0.21
16
116
48
424
1.14
0.34
1.7
1.7
—
—
—
0
0
18
145
1.25
0.34
5.8
1.8
—
—
—
0
0
6
45
1.34
0.33
1.2
1.1
—
—
—
0
0
17
137
1.24
0.32
1.3
1.3
49.00
65.13
mmol/l
1.47
17
110
255
2443
1.06
0.32
1.4
1.4
—
—
—
0
0
11
142
0.77
0.31
1.0
1.1
—
—
—
0
0
11
84
1.31
0.30
1.5
1.1
—
—
—
0
0
11
141
0.78
0.29
1.0
1.1
96.60
3831.69
iu/ml
—
5
33
20
167
1.20
0.28
1.3
1.2
2.10
4.23
u/ml
—
10
57
115
1079
1.07
0.28
1.8
1.7
—
—
—
0
0
8
63
1.27
0.27
2.1
1.5
1.38
1.38
nmol/l
—
8
57
123
1158
1.07
0.27
1.4
1.4
—
—
—
0
0
96
896
1.08
0.27
1.2
1.2
172.86
162.83
iu/ml
0.08
33
373
75
694
1.09
0.26
4.6
3.9
0.39
0.77
%
0.52
23
202
5
74
0.67
0.26
4.0
7.2
—
—
—
0
0
9
73
1.23
0.25
5.2
1.9
40.47
9.05
ug/l
—
9
59
9
75
1.20
0.25
3.4
3.6
—
—
—
0
0
16
191
0.84
0.24
1.3
1.4
—
—
—
0
0
18
152
1.19
0.23
1.2
4.1
—
—
—
0
0
14
115
1.22
0.23
3.1
1.7
—
—
—
0
0
16
190
0.84
0.23
1.3
1.4
—
—
—
0
0
12
97
1.24
0.23
1.5
2.1
—
—
—
0
0
89
836
1.07
0.22
1.4
1.6
—
—
—
0
0
5
41
1.22
0.22
12.0
1.6
—
—
—
0
0
22
191
1.15
0.22
11.6
2.9
7.41
7.43
ph
1.25
22
167
5
42
1.19
0.21
1.6
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
35.70
—
0
10
0
10
0.00
0.21
0.0
3.8
—
—
—
0
0
0
10
0.00
0.21
0.0
8.6
—
—
—
0
0
0
12
0.00
0.21
0.0
3.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.00
—
0
6
11
89
1.24
0.21
2.4
2.2
—
—
—
0
0
11
89
1.24
0.21
2.0
1.4
0.95
0.97
g/l
0.14
11
89
0
13
0.00
0.21
0.0
7.2
—
—
—
0
0
17
198
0.86
0.20
1.3
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
28
251
1.12
0.19
4.0
1.6
—
—
—
0
0
11
91
1.21
0.17
2.4
2.2
4.22
3.96
mmol/l
1.01
11
91
11
91
1.21
0.17
2.4
2.2
103.45
105.79
mmol/l
1.15
11
91
8
69
1.16
0.16
1.7
1.6
14.38
19.08
nmol/l
—
8
64
6
78
0.77
0.15
1.5
1.3
1.69
1.65
g/l
—
6
78
9
80
1.13
0.15
1.6
1.5
—
—
—
0
0
30
275
1.09
0.14
8.0
4.5
—
—
—
0
0
75
786
0.95
0.13
5.2
3.7
—
—
—
0
0
17
151
1.13
0.13
8.6
2.9
—
—
—
0
0
13
113
1.15
0.13
1.9
1.5
—
—
—
0
0
34
318
1.07
0.11
3.7
1.5
—
—
—
0
0
5
48
1.04
0.09
1.2
1.8
1.24
1.25
nmol/l
—
5
40
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
34
322
1.06
0.08
3.6
1.5
—
—
—
0
0
34
322
1.06
0.08
3.6
1.5
—
—
—
0
0
7
65
1.08
0.08
15.6
11.0
0.77
0.67
mmol/l
—
7
57
31
293
1.06
0.08
3.4
1.5
—
—
—
0
0
22
205
1.07
0.08
5.4
2.0
—
—
—
0
0
34
323
1.05
0.07
3.6
1.5
—
—
—
0
0
19
176
1.08
0.07
1.2
1.2
—
—
—
0
0
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
22
206
1.07
0.07
1.1
1.2
—
—
—
0
0
9
102
0.88
0.06
1.2
1.1
—
—
—
0
0
16
149
1.07
0.05
1.1
1.3
—
—
—
0
0
13
140
0.93
0.04
1.1
1.1
—
—
—
0
0
845
8430
1.01
0.04
21.7
13.9
14.76
14.67
%
0.20
835
8296
13
121
1.08
0.03
1.5
1.7
4.28
4.69
ug/l
—
8
97
29
280
1.04
0.03
4.8
3.9
18.55
28.53
u/ml
0.91
29
272
17
179
0.95
0.03
1.1
1.0
6.46
2.26
u/ml
—
9
91
10
92
1.09
0.03
1.8
2.0
89.46
90.27
%
—
10
92
14
132
1.06
0.02
1.6
1.5
—
—
—
0
0
45
460
0.98
0.02
1.1
1.1
—
—
—
0
0
15
158
0.95
0.02
1.1
1.0
0.95
2.77
u/ml
—
5
65
19
182
1.04
0.02
4.5
3.6
16.67
19.60
mg/l
0.24
12
114
38
373
1.02
0.01
1.2
1.3
—
—
—
0
0
19
192
0.99
0.00
1.1
1.1
—
—
—
0
0
19
191
0.99
0.00
1.1
1.1
—
—
—
0
0
12
115
1.04
0.00
2.7
5.2
9.74
50.94
u/ml
—
5
33
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
4249.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
70.58
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
111.00
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
34.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.5
1.3
72.67
70.02
umol/l
—
6
61
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
205.38
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
601.40
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
359.33
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.1
—
55.57
—
0
7
9
90
1.00
-0.00
1.2
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_VULVAL_LSIL and mortality.

Females

Parameter HR [95% CI] p-value
N14_VULVAL_LSIL 0.98 [0.83, 1.16] 0.81
Birth year 0.998 [0.99, 1.01] 0.701

During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 1884 females with N14_VULVAL_LSIL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_VULVAL_LSIL.

N-year risk Females Males
1 0.081% No data
5 0.557% No data
10 1.448% No data
15 2.86% No data
20 5.428% No data

Relationships between endpoints

Index endpoint: N14_VULVAL_LSIL – LSIL lesion of the vulva

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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