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Infliximab

RX_L04AB02

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC L04AB02

1 out of 7 registries used, show all original rules.

286

4. Check minimum number of events

Min. number of events 3
286

5. Include endpoints

None

286

6. Filter based on genotype QC (FinnGen only)

286

Control definitions (FinnGen only)

Control exclude
RX_L04AB

Extra metadata

First used in FinnGen datafreeze
DF4

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 286 151 135
Unadjusted period prevalence (%) 0.06 0.05 0.06
Median age at first event (years) 44.31 45.61 42.86

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
249
9
2089.22
313.73
3.7
3.2
10.2
7.3
mg/l
—
232
9
193
212
25.92
182.03
2.4
1.4
—
—
—
0
0
230
692
12.87
86.95
19.9
5.1
—
—
—
0
0
269
1028
28.20
79.54
23.2
5.4
2.7
2.8
%
0.51
269
976
270
1037
29.67
79.46
23.5
5.7
9.0
8.3
%
4.73
270
993
171
414
8.79
77.31
1.4
1.7
—
—
—
0
0
262
996
20.43
76.71
23.7
5.5
0.9
0.7
%
6.24
262
944
270
1068
28.31
76.08
22.5
5.2
53.0
56.2
%
5.29
270
1024
270
1083
27.69
74.49
23.4
5.3
32.9
29.6
%
6.33
270
1040
169
421
8.37
73.68
3.3
1.9
2.5
2.9
mg/l
1.66
161
361
179
596
6.35
53.81
1.5
1.7
—
—
—
0
0
82
144
7.58
47.80
9.1
5.5
0.1
0.1
%
0.34
34
42
84
157
7.16
46.05
9.0
5.2
0.2
0.8
%
1.89
34
50
77
142
7.05
42.54
9.5
5.5
0.0
0.1
%
0.74
29
39
77
146
6.85
41.33
6.9
5.0
0.1
0.5
%
1.72
24
35
100
259
5.40
38.15
1.2
1.6
—
—
—
0
0
209
971
5.28
37.72
23.1
7.8
0.0
0.0
e9/l
0.34
199
793
111
340
4.70
34.04
1.5
1.4
467.4
400.6
titre
0.17
35
63
144
571
4.07
30.47
16.7
4.5
—
—
—
0
0
261
1593
8.30
30.34
10.6
3.3
11.5
8.3
mm/h
3.87
248
1489
166
776
3.72
26.53
1.6
2.1
—
—
—
0
0
77
217
4.49
25.55
2.3
2.1
23.3
24.7
%
0.34
68
192
129
525
3.65
25.30
16.5
6.3
—
—
—
0
0
23
0
+∞
24.31
1.3
0.0
8.1
—
mg/l
—
18
0
62
156
4.80
23.61
1.3
1.2
—
—
—
0
0
31
40
8.57
22.99
1.1
1.2
—
—
—
0
0
286
2354
+∞
22.78
35.0
10.2
11.6
20.5
mg/l
14.10
271
1748
41
75
6.21
22.20
1.3
1.2
—
—
—
0
0
32
46
7.71
21.67
1.2
1.3
223.0
227.2
u/ml
0.03
20
27
25
29
9.35
20.07
1.8
2.8
1.3
2.1
%
0.44
19
24
182
1010
3.21
20.06
4.9
6.0
11.9
10.7
umol/l
0.58
176
968
74
253
3.60
18.23
1.2
1.2
—
—
—
0
0
21
23
9.77
17.53
2.3
2.8
—
—
—
0
0
286
2489
+∞
16.25
35.5
8.2
28.0
29.7
u/l
0.88
286
2430
20
23
9.27
16.08
1.8
2.6
52.6
63.1
%
1.20
14
17
128
643
2.79
15.90
1.9
1.7
93.5
97.6
pmol/l
0.52
98
330
32
69
5.10
14.39
1.1
1.4
—
—
—
0
0
94
428
2.78
13.79
2.4
4.5
—
—
—
0
0
19
26
7.76
13.28
1.1
1.3
—
—
—
0
0
146
837
2.52
13.23
2.3
1.9
—
—
—
0
0
22
40
5.88
11.84
7.4
3.0
4.1
4.5
e9/l
0.33
22
40
22
40
5.88
11.84
7.3
3.4
57.7
57.5
%
0.04
22
40
38
121
3.47
10.17
1.2
1.2
—
—
—
0
0
96
536
2.19
8.41
1.5
1.3
2.5
2.2
g/l
1.67
73
356
21
50
4.45
8.35
3.0
2.3
—
—
—
0
0
266
2243
3.66
8.11
10.5
10.6
139.3
139.7
mmol/l
1.86
260
2189
21
52
4.28
7.95
1.1
1.3
—
—
—
0
0
266
2254
3.58
7.81
10.6
10.6
3.9
3.9
mmol/l
3.44
260
2189
156
1066
2.02
7.80
5.6
3.9
0.0
0.0
estimate
0.00
42
206
110
664
2.07
7.76
4.0
3.1
25.5
110.1
e6/l
0.78
80
443
11
6
18.99
7.66
1.4
1.7
—
—
—
0
0
11
15
7.59
7.60
1.6
1.2
—
—
—
0
0
156
1079
1.98
7.40
4.6
2.9
0.1
0.0
estimate
0.49
39
192
119
757
1.98
7.12
2.8
6.3
1.2
1.2
mmol/l
1.25
110
706
154
1071
1.95
7.08
4.6
2.8
0.0
0.0
estimate
0.00
40
205
41
168
2.68
7.07
4.5
2.5
4.4
4.0
e9/l
0.38
29
150
246
2032
2.51
7.01
35.4
12.4
13.6
13.4
%
1.18
246
2000
128
846
1.93
6.76
3.5
7.0
1.2
1.2
mmol/l
2.24
113
724
286
2701
+∞
6.56
43.2
15.0
4.5
4.7
e12/l
4.48
286
2648
286
2700
+∞
6.56
43.0
14.9
91.7
89.8
fl
9.38
286
2676
286
2700
+∞
6.56
43.0
14.9
30.7
30.1
pg
6.53
286
2676
286
2698
+∞
6.53
43.3
15.0
286.2
256.6
e9/l
10.72
286
2651
20
56
3.76
6.44
1.4
1.2
—
—
—
0
0
277
2513
4.25
6.42
18.6
9.3
—
—
—
0
0
286
2703
+∞
6.36
43.2
15.1
6.8
6.6
e9/l
1.01
286
2650
286
2703
+∞
6.36
43.3
15.1
138.7
139.8
g/l
0.78
286
2676
90
537
1.99
6.34
3.2
2.6
12.5
54.1
e6/l
2.13
74
411
92
557
1.96
6.20
5.6
3.1
0.0
0.0
estimate
0.50
41
204
58
300
2.17
5.96
2.2
1.5
375.3
24723673.8
pmol/l
0.50
53
271
24
80
3.18
5.96
1.3
1.2
—
—
—
0
0
32
131
2.62
5.52
5.5
3.1
—
—
—
0
0
80
479
1.93
5.49
2.7
2.5
0.3
0.3
e6/l
0.21
64
357
68
392
1.96
5.18
1.4
1.3
13.8
20.9
iu/ml
1.00
18
116
45
224
2.20
5.06
1.9
1.5
1057.6
1163.9
nmol/l
0.31
32
178
81
500
1.86
5.01
2.3
2.4
—
—
—
0
0
66
384
1.93
4.88
1.4
1.3
14.2
7.3
u/ml
0.36
22
173
187
1481
1.76
4.83
5.9
3.4
—
—
—
0
0
23
87
2.79
4.61
1.4
1.4
—
—
—
0
0
81
513
1.81
4.57
2.1
3.6
7.4
7.4
ph
2.33
12
92
62
366
1.89
4.36
3.3
2.3
3.6
8.2
e6/l
1.30
57
325
74
466
1.79
4.23
4.3
3.0
—
—
—
0
0
33
156
2.26
4.19
10.2
13.3
1.0
1.2
inr
—
5
28
50
279
1.96
4.14
1.4
2.2
—
—
—
0
0
23
93
2.60
4.08
2.3
2.1
104.9
76.1
e9/l
0.61
14
68
45
247
1.98
3.91
2.3
2.4
6.2
8.0
umol/l
0.39
39
205
32
156
2.18
3.79
1.1
1.1
—
—
—
0
0
87
590
1.68
3.78
1.4
1.3
0.8
1.0
u/ml
0.76
29
174
8
12
6.82
3.70
1.0
1.0
—
—
—
0
0
16
56
2.97
3.69
1.1
1.1
—
—
—
0
0
90
620
1.66
3.67
4.9
5.9
1.0
1.1
inr
0.64
38
198
45
253
1.92
3.64
1.5
1.7
—
—
—
0
0
9
18
5.13
3.40
1.8
1.3
—
—
—
0
0
71
478
1.65
3.12
2.0
2.3
324.1
2959.8
umol/l
0.99
63
435
24
113
2.23
3.10
3.0
2.1
—
—
—
0
0
8
16
5.11
3.07
1.1
1.0
1342.0
1353.8
miu/ml
—
8
16
33
180
1.94
2.93
3.6
2.8
—
—
—
0
0
7
13
5.49
2.88
1.4
1.0
—
—
—
0
0
17
73
2.41
2.71
1.4
1.2
—
—
—
0
0
11
38
2.97
2.61
1.7
1.6
—
—
—
0
0
12
46
2.68
2.39
1.1
1.1
—
—
—
0
0
40
249
1.71
2.35
1.3
1.5
—
—
—
0
0
85
635
1.48
2.31
4.3
2.3
—
—
—
0
0
6
13
4.69
2.28
1.7
1.5
12.0
9.2
umol/l
—
6
13
70
504
1.51
2.27
5.5
3.0
1.0
1.0
kg/l
—
8
64
25
136
1.92
2.26
1.2
1.4
—
—
—
0
0
252
2325
1.71
2.26
24.3
10.5
41.0
41.7
%
0.94
210
1945
27
153
1.84
2.17
3.1
4.5
—
—
—
0
0
239
2194
1.54
1.99
33.2
12.7
333.7
334.6
g/l
0.81
239
2185
6
16
3.81
1.94
2.3
1.9
—
—
—
0
0
6
16
3.81
1.94
1.0
1.1
—
—
—
0
0
6
18
3.38
1.75
1.0
1.1
—
—
—
0
0
5
13
3.89
1.72
2.4
1.8
—
—
—
0
0
23
135
1.77
1.68
1.4
1.5
200.1
282.7
miu/ml
—
9
73
6
20
3.04
1.59
1.2
1.3
—
—
—
0
0
0
39
0.00
1.35
0.0
18.9
—
1307.6
—
0
39
0
40
0.00
1.33
0.0
5.4
—
376.1
—
0
34
6
24
2.53
1.31
1.2
1.4
—
—
—
0
0
5
117
0.42
1.28
1.6
1.5
—
—
—
0
0
8
37
2.19
1.22
1.1
1.2
—
—
—
0
0
5
20
2.53
1.15
1.4
1.9
—
—
—
0
0
5
114
0.43
1.15
1.6
1.4
—
—
—
0
0
5
114
0.43
1.15
1.6
1.4
—
—
—
0
0
0
36
0.00
1.14
0.0
18.8
—
11.0
—
0
30
0
36
0.00
1.14
0.0
18.8
—
104.5
—
0
30
5
21
2.40
1.09
1.0
1.2
—
—
—
0
0
28
197
1.47
1.05
1.3
1.2
59.4
114.2
iu/ml
—
10
82
58
465
1.31
1.01
2.3
2.3
—
—
—
0
0
31
227
1.41
0.95
2.5
2.3
12.7
15.3
nmol/l
1.32
31
216
59
716
0.78
0.94
1.4
1.6
—
—
—
0
0
6
27
2.25
0.94
2.0
2.2
—
—
—
0
0
6
27
2.25
0.94
1.2
1.2
—
—
—
0
0
33
434
0.73
0.93
3.5
3.5
16.0
235.3
mg/l
0.81
16
291
35
455
0.74
0.91
4.2
4.2
2.0
12.0
mg/mmol
3.04
20
303
8
45
1.80
0.85
1.9
1.7
—
—
—
0
0
12
73
1.67
0.83
1.8
1.9
—
—
—
0
0
0
27
0.00
0.78
0.0
1.8
—
—
—
0
0
22
158
1.43
0.77
1.7
1.2
—
15.3
—
0
6
0
28
0.00
0.76
0.0
2.9
—
21.1
—
0
28
7
38
1.86
0.74
4.1
3.1
3.2
3.3
u/ml
—
7
32
5
25
2.02
0.73
1.0
1.0
—
—
—
0
0
27
204
1.36
0.72
1.1
2.0
—
—
—
0
0
7
40
1.77
0.72
1.0
1.1
—
—
—
0
0
70
602
1.22
0.69
2.7
3.1
2.3
2.4
mmol/l
0.97
70
548
50
592
0.81
0.65
2.6
3.1
9.1
8.8
mmol/l
0.12
42
520
32
253
1.30
0.64
1.1
2.0
—
—
—
0
0
13
87
1.52
0.64
5.4
2.7
0.1
0.1
e6/l
0.08
13
82
32
254
1.29
0.63
1.1
2.0
—
—
—
0
0
32
254
1.29
0.63
1.1
2.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
7
113
0.61
0.59
1.3
3.4
5.3
5.1
kpa
—
7
105
39
469
0.80
0.58
1.7
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
0.1
—
0
6
24
185
1.32
0.58
1.5
1.6
—
—
—
0
0
23
295
0.76
0.58
2.0
1.9
—
—
—
0
0
31
252
1.26
0.52
1.1
1.8
—
—
—
0
0
75
667
1.17
0.52
2.7
2.7
10.2
28.6
ng/l
3.92
28
328
7
45
1.57
0.49
1.0
1.2
—
—
—
0
0
7
47
1.50
0.48
1.3
1.7
—
—
—
0
0
29
237
1.25
0.47
1.1
2.0
—
—
—
0
0
51
444
1.18
0.46
1.6
1.5
—
—
—
0
0
39
452
0.84
0.42
2.3
2.8
—
—
—
0
0
0
16
0.00
0.41
0.0
2.7
—
—
—
0
0
27
224
1.23
0.40
1.1
1.2
—
—
—
0
0
5
35
1.44
0.39
1.2
1.8
—
—
—
0
0
8
112
0.71
0.38
1.1
2.5
—
—
—
0
0
210
2167
0.88
0.38
3.2
3.2
1.3
1.3
mmol/l
0.40
205
2049
18
143
1.28
0.38
1.4
1.4
—
—
—
0
0
186
1932
0.89
0.37
3.9
4.2
36.2
38.0
mmol/mol
2.27
181
1845
10
72
1.40
0.37
2.3
5.0
—
—
—
0
0
6
42
1.44
0.36
2.2
1.8
—
—
—
0
0
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
55
495
1.14
0.33
1.4
1.8
0.6
0.8
mg/l
0.50
33
369
6
47
1.28
0.32
1.0
1.0
—
—
—
0
0
19
156
1.23
0.32
1.0
1.1
—
—
—
0
0
7
100
0.69
0.31
1.9
9.8
—
—
—
0
0
94
1001
0.91
0.29
1.9
2.2
—
—
—
0
0
38
337
1.15
0.29
1.6
3.2
4.5
392.4
ng/l
2.45
17
197
28
243
1.17
0.28
1.1
1.2
—
—
—
0
0
11
139
0.78
0.27
2.3
13.1
118.8
125.5
g/l
0.70
11
130
222
2269
0.90
0.26
3.5
3.7
2.9
2.9
mmol/l
0.28
216
2146
5
71
0.70
0.26
1.8
11.9
23.2
24.3
mmol/l
—
5
64
9
72
1.26
0.26
2.1
2.2
—
—
—
0
0
23
264
0.86
0.24
1.2
1.4
—
—
—
0
0
10
79
1.28
0.22
1.7
1.7
—
—
—
0
0
205
2096
0.92
0.22
3.1
3.4
5.5
5.7
mmol/l
1.28
197
1974
13
156
0.83
0.22
2.0
6.6
1.2
1.3
mmol/l
0.18
13
149
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
31.8
—
0
6
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
13.1
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
12.8
—
0
14
8
72
1.11
0.16
1.0
1.3
—
—
—
0
0
20
178
1.13
0.15
1.2
2.7
—
—
—
0
0
9
79
1.14
0.15
2.0
2.4
—
—
—
0
0
23
254
0.90
0.15
1.7
2.1
0.5
0.6
ug/l
0.82
11
116
7
89
0.78
0.14
1.1
1.1
—
—
—
0
0
8
97
0.82
0.14
2.1
2.9
127.0
135.3
g/l
—
8
97
11
126
0.87
0.11
2.2
2.2
1.7
7.4
ug/l
3.86
11
119
142
1390
1.04
0.11
2.6
2.9
—
—
—
0
0
228
2255
1.05
0.10
3.4
3.5
4.7
4.8
mmol/l
0.15
220
2147
15
135
1.12
0.10
1.1
1.2
—
—
—
0
0
6
73
0.82
0.07
1.0
1.1
—
—
—
0
0
6
73
0.82
0.07
1.0
1.1
—
—
—
0
0
177
1748
1.03
0.07
4.0
3.9
14.7
14.5
pmol/l
0.43
170
1639
14
152
0.92
0.06
1.9
3.5
—
—
—
0
0
207
2083
0.98
0.03
4.4
4.4
1.6
2.3
mu/l
0.70
198
1969
63
622
1.02
0.01
1.9
2.1
—
—
—
0
0
224
2247
0.99
0.01
3.3
3.5
1.5
1.4
mmol/l
0.55
218
2133
24
242
0.99
0.00
1.2
1.4
—
—
—
0
0
42
423
0.99
0.00
1.2
1.3
—
—
—
0
0
13
134
0.97
0.00
2.2
8.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.1
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
6.8
—
25.5
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
250.8
—
0
5
5
49
1.02
0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
8
87
0.92
0.00
1.9
2.1
0.9
1.6
%
—
8
87
9
95
0.95
0.00
2.2
2.8
69.7
68.0
g/l
—
9
89
0
9
0.00
0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
81.4
—
0
9
0
6
0.00
0.00
0.0
1.0
—
5.7
—
0
6
9
90
1.00
0.00
1.6
1.2
—
—
—
0
0
5
55
0.91
0.00
5.8
2.1
3.0
4.8
umol/l
—
5
38
7
72
0.97
0.00
12.4
7.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
12.7
—
—
—
0
0
5
53
0.94
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: RX_L04AB02 – Infliximab

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).