This is a non-core endpoint: only basic statistics are computed.
See its core counterpart C3_HEPATOCELLU_CARC_EXALLC for full statistics.
Hepatocellular carcinoma
C3_HEPATOCELLU_CARC
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
695 |
4. Check minimum number of eventsNone |
695 |
5. Include endpointsNone |
695 |
6. Filter based on genotype QC (FinnGen only) |
695 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF8
Similar endpoints
↥List of similar endpoints to
Hepatocellular carcinoma
based on the number of shared cases.
Similar with more cases:
- Hepatocellular carcinoma, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of liver and intrahepatic bile ducts
- Malignant neoplasm of intrahepatic ducts, biliary tract and gallbladder
- Malignant neoplasm of intrahepatic ducts, biliary tract and gallbladder, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of digestive organs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 695 | 94 | 601 |
| Unadjusted period prevalence (%) | 0.23 | 0.03 | 0.26 |
| Median age at first event (years) | 72.93 | 74.32 | 72.71 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 635
- Matched controls
- 6348
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
323.0
503
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
14052.4
323.0
600
5
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
83.8
203.9
224
41
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
96.3
201.6
217
34
198
Kela drug reimbursment
Sorafenib
2091.7
168.6
156
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
244.2
135.6
135
7
8000/3-C22.0
ICD-O-3
Neoplasm, malignant of liver
+∞
120.8
112
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
69.5
120.6
137
25
130
Kela drug reimbursment
Malignant tumour
10.2
119.0
273
437
L01XE05
ATC
[U] sorafenib; oral
1340.3
117.6
111
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
41.2
96.5
121
36
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
9.4
83.7
191
278
Z51.5
ICD-10 Finland
Palliative care
9.3
79.1
181
262
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
54.3
71.8
85
18
323
Kela drug reimbursment
Sorafenib
+∞
61.5
58
*
N02AA05
ATC
oxycodone; systemic
4.9
60.8
246
725
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
634.6
59.7
58
*
R18
ICD-10 Finland
Ascites
24.6
58.9
84
39
C03DA01
ATC
spironolactone; oral
5.4
57.7
205
519
JN4CD
NOMESCO Finland
Very extensive body CT
9.1
55.1
123
163
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
37.3
50.2
64
19
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
14.0
44.5
78
63
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
9.2
43.8
96
121
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
20.3
43.8
66
36
Z94.4
ICD-10 Finland
Liver transplant status
161.1
43.4
45
*
JJ6LT
NOMESCO Finland
Coagulation of focal hepatic lesion under ultrasound guidance
+∞
43.2
41
*
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
+∞
42.1
40
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
213.0
39.3
40
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
12.0
36.9
69
64
A03FA01
ATC
metoclopramide; systemic, rectal
3.6
36.7
206
755
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
36.3
165
506
103
Kela drug reimbursment
Diabetes, insulin-treated
3.0
36.1
301
1462
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
17.9
35.7
56
34
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
70.9
35.4
40
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
33.1
277
1327
127
Kela drug reimbursment
Transplant complication
23.5
32.2
46
21
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.3
31.5
104
228
A10BA02
ATC
metformin; oral
2.8
31.5
295
1505
3019
Kela drug reimbursment
Lenvatinib
+∞
30.5
29
*
C03CA01
ATC
furosemide; systemic
2.6
29.5
339
1927
L01EX02
ATC
sorafenib; oral
+∞
29.4
28
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.8
29.2
264
1301
1508
Kela drug reimbursment
Lenvatinib
+∞
28.3
27
*
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
25.2
27.3
38
16
K76.9
ICD-10 Finland
Liver disease, unspecified
22.4
25.0
36
17
L04AA06
ATC
mycophenolic acid; systemic
14.4
24.9
42
31
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
36.1
24.5
31
9
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
39.3
24.1
30
8
A06AD11
ATC
lactulose; oral
2.8
23.0
177
770
K92.0
ICD-10 Finland
Haematemesis
6.7
22.9
60
98
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
124.5
22.7
24
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.6
22.3
82
200
L01EX08
ATC
lenvatinib; oral
+∞
22.0
21
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
5.4
21.7
68
139
176
Kela drug reimbursment
Regorafenib
113.8
20.7
22
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.6
20.1
73
175
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
11.9
19.7
36
32
D77
ICPC
Malignant digestive neopl other/NOS
25.5
19.7
27
11
A07AA11
ATC
rifaximin; oral
108.4
19.7
21
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
18.9
322
2054
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
18.8
111
401
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
25.9
18.3
25
10
L04AD01
ATC
ciclosporin; systemic
11.9
18.2
33
29
A10AE04
ATC
insulin glargine; parenteral
3.1
18.1
110
404
JJA44
NOMESCO Finland
Laparoscopic destruction of lesion of liver
+∞
17.8
17
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
17.5
211
1142
T90
ICPC
Diabetes non-insulin dependent
2.3
17.1
207
1119
A05AA02
ATC
ursodeoxycholic acid; oral
14.6
16.9
28
20
A10BB12
ATC
glimepiride; oral
2.9
16.9
111
429
JN4AD
NOMESCO Finland
Body CT examination
3.3
16.8
92
311
JJB30
NOMESCO Finland
Excision of two segments of liver
+∞
16.7
16
*
JJ7LT
NOMESCO Finland
Coagulation of focal hepatic lesion under CT guidance
174.4
16.6
17
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
25.2
16.1
22
9
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.2
15.8
214
1209
JJB50
NOMESCO Finland
Excision of segments V, VI, VII and VIII of liver
61.6
15.8
18
*
JN4BD
NOMESCO Finland
Extensive body CT
2.7
15.7
120
505
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
19.8
15.6
23
12
C22
ICD-10 Finland
Malignant neoplasm of liver and intrahepatic bile ducts
87.3
15.6
17
*
D13.4
ICD-10 Finland
Benign neoplasm: Liver
163.8
15.5
16
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
15.5
83
279
C22.7
ICD-10 Finland
Malignant neoplasm: Other specified carcinomas of liver
+∞
14.6
14
*
JJB71
NOMESCO Finland
Laparoscopic resection of liver
82.0
14.6
16
*
JJ5AT
NOMESCO Finland
NA
82.0
14.6
16
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
14.5
82
286
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.4
14.3
142
690
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
43.5
14.2
17
*
A10BH01
ATC
sitagliptin; oral
2.7
14.0
101
410
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
14.0
13.8
23
17
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.9
13.6
86
323
PC2SC
NOMESCO Finland
Liver angiography with X-ray
+∞
13.6
13
*
K72.1
ICD-10 Finland
Chronic hepatic failure
26.4
13.4
18
7
JJB10
NOMESCO Finland
Atypcal resection of liver
41.0
13.2
16
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
4.8
13.0
43
94
D97
ICPC
Liver disease NOS
19.5
13.0
19
10
L01XE21
ATC
[U] regorafenib; oral
71.3
12.6
14
*
JN3GE
NOMESCO Finland
Intraoperative ultrasound examination of abdomen
132.5
12.5
13
*
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
7.7
12.3
28
38
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
27.3
12.1
16
6
TK800
NOMESCO Finland
Hemodialysis
5.2
11.9
36
72
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
11.8
162
902
XJA00
NOMESCO Finland
Intraoperative abdominal ultrasonography
122.1
11.5
12
*
A98
ICPC
Health maint/preventive medicine
0.5
11.4
374
4597
I81
ICD-10 Finland
Portal vein thrombosis
15.4
11.4
18
12
369
Kela drug reimbursment
Regorafenib
44.1
11.0
13
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
9.8
10.8
21
22
C10AA05
ATC
atorvastatin; oral
0.5
10.5
131
2106
SPAT1262
SPAT
Handing over of treatment supplies
2.0
10.5
152
862
L01XE29
ATC
[U] lenvatinib; oral
+∞
10.4
10
*
A10AE05
ATC
insulin detemir; parenteral
3.1
10.4
58
198
WZC30
NOMESCO Finland
Teaching
2.3
10.3
96
449
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
10.2
304
2193
C07AA05
ATC
propranolol; systemic
2.3
10.1
97
456
A02BC02
ATC
pantoprazole; systemic
1.7
9.9
387
3018
K70.4
ICD-10 Finland
Alcoholic hepatic failure
26.5
9.8
13
5
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
9.8
9.8
19
20
205
Kela drug reimbursment
Chronic hypertension
1.7
9.7
265
1857
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
9.6
89
412
K92.1
ICD-10 Finland
Melaena
2.7
9.6
67
268
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
15.3
9.5
15
10
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
30.5
9.4
12
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
9.4
9
*
1550A
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Liver, primary
+∞
9.4
9
*
JJA20
NOMESCO Finland
Open biopsy of liver
22.1
9.4
13
6
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.2
9.2
102
513
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
5.3
9.2
27
53
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.5
9.0
41
123
TJA10
NOMESCO Finland
Laparocentesis
24.4
8.9
12
5
XX4BW
NOMESCO Finland
NA
24.4
8.9
12
5
PC1BC
NOMESCO Finland
Extensive angiography of aorta and abdominal arteries
14.3
8.7
14
10
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
50.7
8.7
10
*
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
10.2
8.6
16
16
JJB20
NOMESCO Finland
Excision of single segment of liver
91.2
8.4
9
*
K70.1
ICD-10 Finland
Alcoholic hepatitis
13.0
8.4
14
11
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
8.3
8
*
L01EX05
ATC
regorafenib; oral
+∞
8.3
8
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.8
8.2
52
196
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
8.1
110
601
WX402
NOMESCO Finland
General anaesthesia
2.1
8.1
89
449
K70.0
ICD-10 Finland
Alcoholic fatty liver
9.1
8.1
16
18
E66.00
ICD-10 Finland
Metabolic syndrome
3.1
8.0
43
146
A10BB01
ATC
glibenclamide; oral
2.5
7.7
62
267
G04CA52
ATC
tamsulosin and dutasteride; systemic
0.4
7.7
31
738
JJA43
NOMESCO Finland
Destruction of lesion of liver
45.5
7.7
9
*
N40
ICD-10 Finland
Hyperplasia of prostate
0.6
7.7
134
2006
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
7.6
35
792
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
7.6
65
291
ZXC40
NOMESCO Finland
Use of ultrasound
18.6
7.6
11
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
7.6
103
565
A10BG03
ATC
pioglitazone; oral
3.5
7.5
33
97
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
7.5
166
1073
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.7
7.5
48
184
UJF32
NOMESCO Finland
Coloscopy
1.7
7.4
179
1192
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.0
7.3
28
73
A04AA01
ATC
ondansetron; systemic, rectal
2.7
7.3
48
186
JJB40
NOMESCO Finland
Excision of segments II, III and IV of liver
+∞
7.3
7
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
5.3
7.3
21
41
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
7.2
130
789
J01MA12
ATC
levofloxacin; systemic
1.7
7.1
152
971
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.2
7.0
35
114
B01AB10
ATC
tinzaparin; parenteral
2.5
7.0
54
228
R4110
NOMESCO Finland
Physiotherapy
1.7
6.9
161
1055
L04AX01
ATC
azathioprine; systemic
3.5
6.8
30
89
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
16.9
6.8
10
6
K72.9
ICD-10 Finland
Hepatic failure, unspecified
16.9
6.8
10
6
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
6.8
29
677
A10BD07
ATC
metformin and sitagliptin; systemic
2.8
6.7
40
148
B01AB05
ATC
enoxaparin; parenteral
1.6
6.7
199
1394
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.8
6.6
42
158
R50.9
ICD-10 Finland
Fever, unspecified
1.9
6.6
99
563
K83.0
ICD-10 Finland
Cholangitis
4.0
6.4
24
62
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.4
112
671
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
6.3
95
542
K76.89
ICD-10 Finland
Other specified diseases of liver
18.2
6.3
9
5
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
6.3
6
*
C22.2
ICD-10 Finland
Malignant neoplasm: Hepatoblastoma
+∞
6.3
6
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.0
6.2
23
59
E83.1
ICD-10 Finland
Disorders of iron metabolism
27.0
6.2
8
*
A79
ICPC
Malignancy NOS
5.1
6.2
18
36
WW200
SPAT
NA
0.2
6.2
5
274
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.2
264
2011
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.3
6.1
29
92
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_HEPATOCELLU_CARC – Hepatocellular carcinoma
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).