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Hepatocellular carcinoma, excluding all cancers (controls excluding all cancers)

Endpoint Browser PheWeb

C3_HEPATOCELLU_CARC_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C22.0&
  • Cause of death: ICD-10 — C22.0&
  • Cancer registry: Topography ICD-O-3 — C22
  • Cancer registry: Morphology ICD-O-3 — 817[0-5]
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

982

4. Check minimum number of events

None

982

5. Include endpoints

None

982

6. Filter based on genotype QC (FinnGen only)

982

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

↥

List of similar endpoints to Hepatocellular carcinoma, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 982 172 810
Unadjusted period prevalence (%) 0.30 0.06 0.36
Median age at first event (years) 72.05 71.92 72.08

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
635
Matched controls
6351
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
+∞
323.0
503
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
+∞
323.0
600
*
130
Kela drug reimbursment
Malignant tumour
+∞
312.0
273
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
287.2
231.9
224
12
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
252.5
222.3
217
13
198
Kela drug reimbursment
Sorafenib
+∞
170.7
156
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
+∞
146.7
135
*
Z51.5
ICD-10 Finland
Palliative care
29.7
131.7
181
84
8000/3-C22.0
ICD-O-3
Neoplasm, malignant of liver
+∞
120.8
112
*
L01XE05
ATC
[U] sorafenib; oral
+∞
119.6
111
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
62.1
118.3
137
28
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
14.2
105.0
191
186
A03FA01
ATC
metoclopramide; systemic, rectal
10.6
96.0
206
276
N02AA05
ATC
oxycodone; systemic
8.3
95.8
246
447
JN4CD
NOMESCO Finland
Very extensive body CT
36.0
95.0
123
42
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
24.6
84.1
121
60
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
73.4
69
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
48.9
70.4
85
20
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
67.9
64
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
352.0
63.6
63
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
62.5
59
*
323
Kela drug reimbursment
Sorafenib
+∞
61.5
58
*
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
+∞
61.5
58
*
R18
ICD-10 Finland
Ascites
27.5
60.8
84
35
C03DA01
ATC
spironolactone; oral
5.3
57.2
205
523
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
15.7
57.2
96
71
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
25.2
55.2
78
35
JN4BD
NOMESCO Finland
Extensive body CT
9.1
53.8
120
158
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
36.1
52.9
68
21
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
40.7
52.8
66
18
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
49.5
165
380
Z94.4
ICD-10 Finland
Liver transplant status
+∞
47.5
45
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
18.6
46.8
73
44
JN4AD
NOMESCO Finland
Body CT examination
10.8
46.1
92
98
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
43.7
45.5
56
14
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
45.3
43
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.4
44.9
104
144
JJ6LT
NOMESCO Finland
Coagulation of focal hepatic lesion under ultrasound guidance
+∞
43.2
41
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.9
42.5
214
732
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
42.1
40
*
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
+∞
42.1
40
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
42.1
277
1172
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
10.5
40.8
82
88
WF002
NOMESCO Finland
Radical radiotherapy
+∞
38.9
37
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
70.9
35.4
40
6
A04AA02
ATC
granisetron; systemic, transdermal
355.1
34.3
34
*
116
Kela drug reimbursment
Prostate cancer
+∞
33.6
32
*
127
Kela drug reimbursment
Transplant complication
23.5
32.2
46
21
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
31.5
30
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
31.5
301
1556
A04AA01
ATC
ondansetron; systemic, rectal
19.1
31.5
48
27
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.9
31.1
111
265
3019
Kela drug reimbursment
Lenvatinib
+∞
30.5
29
*
L01EX02
ATC
sorafenib; oral
+∞
29.4
28
*
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
31.0
28.8
38
13
H02AB02
ATC
dexamethasone; systemic
21.3
28.6
42
21
N02AX02
ATC
tramadol; systemic, rectal
2.6
28.5
322
1798
C03CA01
ATC
furosemide; systemic
2.6
28.4
339
1953
1508
Kela drug reimbursment
Lenvatinib
+∞
28.3
27
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.7
28.1
264
1326
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
104.8
27.9
30
*
A10BA02
ATC
metformin; oral
2.6
27.8
295
1583
D77
ICPC
Malignant digestive neopl other/NOS
282.3
26.9
27
*
L04AA06
ATC
mycophenolic acid; systemic
16.6
26.3
42
27
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
25.2
24
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
36.1
24.5
31
9
A06AD11
ATC
lactulose; oral
2.9
24.5
177
745
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
24.1
23
*
WZC30
NOMESCO Finland
Teaching
4.2
23.5
96
259
176
Kela drug reimbursment
Regorafenib
+∞
23.1
22
*
K92.0
ICD-10 Finland
Haematemesis
6.6
22.9
60
98
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
86.7
22.8
25
*
K76.9
ICD-10 Finland
Liver disease, unspecified
16.5
22.6
36
23
JN3AD
NOMESCO Finland
Abdominal CT examination
4.5
22.0
83
207
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
22.0
21
*
L01EX08
ATC
lenvatinib; oral
+∞
22.0
21
*
L02AE02
ATC
leuprorelin; implant, parenteral
227.4
21.7
22
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.4
21.3
66
133
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
37.1
20.0
25
7
A07AA11
ATC
rifaximin; oral
108.4
19.7
21
*
B01AB10
ATC
tinzaparin; parenteral
6.0
19.3
54
96
JJB50
NOMESCO Finland
Excision of segments V, VI, VII and VIII of liver
+∞
18.8
18
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.1
18.7
52
92
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
39.7
18.7
23
6
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
195.4
18.6
19
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
18.1
166
781
A05AA02
ATC
ursodeoxycholic acid; oral
17.2
18.0
28
17
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
17.8
162
760
C22
ICD-10 Finland
Malignant neoplasm of liver and intrahepatic bile ducts
+∞
17.8
17
*
JJ7LT
NOMESCO Finland
Coagulation of focal hepatic lesion under CT guidance
+∞
17.8
17
*
JJA44
NOMESCO Finland
Laparoscopic destruction of lesion of liver
+∞
17.8
17
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
9.5
17.6
36
40
A79
ICPC
Malignancy NOS
184.9
17.6
18
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
17.5
211
1138
T90
ICPC
Diabetes non-insulin dependent
2.3
17.4
207
1114
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
26.4
17.0
23
9
B01AB05
ATC
enoxaparin; parenteral
2.3
17.0
199
1059
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
65.1
16.8
19
*
UJF32
NOMESCO Finland
Coloscopy
2.4
16.8
179
908
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
16.7
16
*
JJB10
NOMESCO Finland
Atypcal resection of liver
+∞
16.7
16
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
16.7
16
*
JJB71
NOMESCO Finland
Laparoscopic resection of liver
+∞
16.7
16
*
JJ5AT
NOMESCO Finland
NA
+∞
16.7
16
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
16.7
16
*
JJB30
NOMESCO Finland
Excision of two segments of liver
+∞
16.7
16
*
A10AE04
ATC
insulin glargine; parenteral
2.9
16.7
110
425
L04AD01
ATC
ciclosporin; systemic
9.9
16.6
33
35
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
16.4
304
1967
A10BB12
ATC
glimepiride; oral
2.9
16.3
111
438
J01MA12
ATC
levofloxacin; systemic
2.5
16.1
152
722
B18.2
ICD-10 Finland
Chronic viral hepatitis C
25.2
16.1
22
9
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
+∞
15.7
15
*
A02BC02
ATC
pantoprazole; systemic
2.0
15.6
387
2786
WX402
NOMESCO Finland
General anaesthesia
3.1
15.6
89
313
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
163.8
15.5
16
*
D97
ICPC
Liver disease NOS
39.1
15.5
19
5
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
15.3
110
449
K92.1
ICD-10 Finland
Melaena
3.7
15.0
67
195
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
14.9
89
322
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
21.7
14.7
21
10
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
14.6
14
*
C22.7
ICD-10 Finland
Malignant neoplasm: Other specified carcinomas of liver
+∞
14.6
14
*
L01XE21
ATC
[U] regorafenib; oral
+∞
14.6
14
*
L02BB03
ATC
bicalutamide; oral
153.3
14.5
15
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.6
14.2
41
77
A10BH01
ATC
sitagliptin; oral
2.7
13.9
101
411
I81
ICD-10 Finland
Portal vein thrombosis
30.8
13.9
18
6
JN3GE
NOMESCO Finland
Intraoperative ultrasound examination of abdomen
+∞
13.6
13
*
PC2SC
NOMESCO Finland
Liver angiography with X-ray
+∞
13.6
13
*
369
Kela drug reimbursment
Regorafenib
+∞
13.6
13
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
13.6
13
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
34.8
13.6
17
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
13.5
103
434
K72.1
ICD-10 Finland
Chronic hepatic failure
26.4
13.4
18
7
TK800
NOMESCO Finland
Hemodialysis
6.1
13.3
36
62
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.4
13.2
48
116
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
8.6
13.1
28
34
KCD02
NOMESCO Finland
Transurethral resection of bladder
17.2
13.0
20
12
WW500
NOMESCO Finland
Blood transfusion
6.2
12.9
34
57
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.2
12.7
142
725
J01MA02
ATC
ciprofloxacin; systemic
1.9
12.6
264
1732
D13.4
ICD-10 Finland
Benign neoplasm: Liver
32.7
12.6
16
5
XJA00
NOMESCO Finland
Intraoperative abdominal ultrasonography
+∞
12.5
12
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.5
12
*
C07AA05
ATC
propranolol; systemic
2.6
12.5
97
413
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.8
12.2
82
319
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
16.3
12.2
19
12
SPAT1262
SPAT
Handing over of treatment supplies
2.1
12.0
152
820
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
11.5
11
*
TJA10
NOMESCO Finland
Laparocentesis
122.1
11.5
12
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
122.1
11.5
12
*
R4110
NOMESCO Finland
Physiotherapy
2.0
11.4
161
906
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
11.2
95
423
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.7
10.8
36
80
R50.9
ICD-10 Finland
Fever, unspecified
2.4
10.8
99
457
L01XE29
ATC
[U] lenvatinib; oral
+∞
10.4
10
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
10.4
10
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
10.4
10
*
JJA20
NOMESCO Finland
Open biopsy of liver
33.1
10.4
13
*
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
9.0
10.3
21
24
R4190
NOMESCO Finland
Nutritional therapy
9.3
10.1
20
22
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
40.7
10.0
12
*
205
Kela drug reimbursment
Chronic hypertension
1.7
9.7
265
1853
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.9
9.7
39
105
C10AA05
ATC
atorvastatin; oral
0.5
9.7
131
2065
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
5.6
9.6
27
50
K83.0
ICD-10 Finland
Cholangitis
6.3
9.5
24
39
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
101.4
9.4
10
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.2
9.4
102
510
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
30.5
9.4
12
*
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
12.6
9.4
16
13
JJB20
NOMESCO Finland
Excision of single segment of liver
+∞
9.4
9
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
9.4
9
*
1550A
ICD-9 Finland
Malignant neoplasm of liver and intrahepatic bile ducts, Liver, primary
+∞
9.4
9
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
9.4
9
*
JJA43
NOMESCO Finland
Destruction of lesion of liver
+∞
9.4
9
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
6.6
9.3
23
36
Z2446
NOMESCO Finland
Social worker
3.4
9.3
44
136
ZXE40
NOMESCO Finland
More than seven and less than nine hours
5.0
9.1
28
58
PC1BC
NOMESCO Finland
Extensive angiography of aorta and abdominal arteries
15.9
9.1
14
9
XX4BW
NOMESCO Finland
NA
24.4
8.9
12
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
8.9
130
734
A10AE05
ATC
insulin detemir; parenteral
2.8
8.8
58
223
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
50.7
8.7
10
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.2
8.6
86
415
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
8.6
112
606
ZXC40
NOMESCO Finland
Use of ultrasound
27.9
8.5
11
*
ZX120
NOMESCO Finland
Intravenous
2.8
8.5
55
211
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.3
8
*
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
8.3
8
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
8.3
8
*
L01EX05
ATC
regorafenib; oral
+∞
8.3
8
*
K70.4
ICD-10 Finland
Alcoholic hepatic failure
14.7
8.2
13
9
A98
ICPC
Health maint/preventive medicine
0.6
8.2
374
4461
SPAT1109
SPAT
Analgesia with portable analgesic pump
33.8
8.1
10
*
N02AA01
ATC
morphine; systemic, rectal
9.1
8.1
16
18
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
6.0
8.0
21
36
N05CF01
ATC
zopiclone; oral
1.7
8.0
205
1388
E66.00
ICD-10 Finland
Metabolic syndrome
3.0
7.9
43
148
A10BG03
ATC
pioglitazone; oral
3.7
7.9
33
93
UJK02
NOMESCO Finland
ERCP
4.4
7.8
27
64
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.5
7.7
35
105
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.7
171
1107
XF612
NOMESCO Finland
Measurement of central venous pressure
45.5
7.7
9
*
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.0
7.6
29
75
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
6.8
7.6
18
27
A06AH03
ATC
naloxegol; oral
18.6
7.6
11
6
L04AX01
ATC
azathioprine; systemic
3.8
7.6
30
81
K83.1
ICD-10 Finland
Obstruction of bile duct
7.2
7.5
17
24
ZX050
NOMESCO Finland
Stereotactic radiotherapy
81.0
7.4
8
*
K70.1
ICD-10 Finland
Alcoholic hepatitis
9.5
7.3
14
15
JJB40
NOMESCO Finland
Excision of segments II, III and IV of liver
+∞
7.3
7
*
L01BC06
ATC
capecitabine; oral
+∞
7.3
7
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
7.3
7
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
7.3
7
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
7.3
7
*
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
7.3
7
*
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
+∞
7.3
7
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
7.3
7
*
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
+∞
7.3
7
*
JAH00
NOMESCO Finland
Laparotomy
4.4
7.3
25
59
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
7.3
44
163
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
7.2
35
780
N06DX01
ATC
memantine; oral
0.3
7.2
11
414
JKE25
NOMESCO Finland
Endoscopic external drainage of bile duct
30.4
7.2
9
*
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
30.4
7.2
9
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
7.1
29
691
UJF30
NOMESCO Finland
Ileoscopy through colon
2.5
7.1
55
232
K70.0
ICD-10 Finland
Alcoholic fatty liver
7.1
7.0
16
23
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.1
7.0
79
403
UJD02
NOMESCO Finland
Gastroscopy
2.9
6.9
41
150
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
14.0
6.9
11
8
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
14.0
6.9
11
8
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
11.1
6.8
12
11
K76.89
ICD-10 Finland
Other specified diseases of liver
22.8
6.7
9
*
XQ902
NOMESCO Finland
Other photography
22.8
6.7
9
*
WX882
NOMESCO Finland
High dependency care
3.8
6.6
26
70
G04CA52
ATC
tamsulosin and dutasteride; systemic
0.4
6.5
31
692
K76.6
ICD-10 Finland
Portal hypertension
70.5
6.4
7
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
70.5
6.4
7
*
Y77
ICPC
Malignant neoplasm prostate
70.5
6.4
7
*
WW200
SPAT
NA
0.2
6.4
5
276
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.7
6.3
41
159
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.9
6.3
36
128
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
18.2
6.3
9
5
C22.2
ICD-10 Finland
Malignant neoplasm: Hepatoblastoma
+∞
6.3
6
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
6.3
6
*
TJA40
NOMESCO Finland
Percutaneous local drainage of peritoneal cavity
+∞
6.3
6
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
6.3
6
*
8000/3-C80.9
ICD-O-3
Neoplasm, malignant of unknown primary site
+∞
6.3
6
*
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
+∞
6.3
6
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
26.9
6.2
8
*
A10BD07
ATC
metformin and sitagliptin; systemic
2.7
6.2
40
154
K72.9
ICD-10 Finland
Hepatic failure, unspecified
12.7
6.1
10
8
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.0
6.1
33
115

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_HEPATOCELLU_CARC_EXALLC – Hepatocellular carcinoma, excluding all cancers (controls excluding all cancers)

GWS hits: 3

This endpoint is excluded (different definition than used in FinnGen).