Benign neoplasm: Short bones of upper limb

CD2_BENIGN_BONE_SHORT_UPPER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D16.1&
  • Hospital discharge: ICD-9 2135
  • Hospital discharge: ICD-8 21304
  • Cause of death: ICD-10 D16.1&
  • Cause of death: ICD-9 2135
  • Cause of death: ICD-8 21304

2 out of 7 registries used, show all original rules.

586

4. Check minimum number of events

None

586

5. Include endpoints

None

586

6. Filter based on genotype QC (FinnGen only)

569

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D16
Name in latin
Neoplasma benignum ossium brevium membri superioris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4153 2166 1973
Only index persons 3902 2072 1830
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.07 0.08 0.07
Median age at first event (years)
Whole population 38.27 40.19 36.12
Only index persons 38.06 40.09 35.77

-FinnGen-

Key figures

All Female Male
Number of individuals 569 365 204
Unadjusted period prevalence (%) 0.12 0.13 0.09
Median age at first event (years) 43.45 43.43 43.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
586
Matched controls
5860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
+∞
307.7
445
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
114.6
307.7
193
25
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
30.4
104.0
70
26
2135A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Short bones of upper limb
+∞
94.4
88
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
6.4
76.7
154
311
21304
ICD-8 Finland
Benign neoplasm of bone and cartilage, Ossium brevium extremitatis superioris
+∞
63.7
60
*
9102
FHL
Trepanation or removal of the local bone process
94.5
61.4
67
8
D21.1
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder
17.4
43.0
36
22
WX204
NOMESCO Finland
Axillary plexus blockaced
7.6
42.4
63
91
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
11.2
40.7
44
42
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
9.7
34.3
41
45
NDK10
NOMESCO Finland
Incision or excision of a bone of hand
60.0
29.4
34
6
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
135.8
24.8
26
*
NDK99
NOMESCO Finland
Other operation on bone of hand or wrist
83.4
21.8
24
*
NDR30
NOMESCO Finland
Complete excision of soft tissue tumour of wrist or hand
76.2
19.8
22
*
S62.6
ICD-10 Finland
Fracture of other finger
4.3
18.7
50
124
ND1CG
NOMESCO Finland
Wrist and hand extensive MRI examination with high intensity magnet
16.9
16.7
26
16
WX203
NOMESCO Finland
Infraclavicular plexus blockade
5.5
14.8
29
55
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
14.7
14.6
24
17
NDK00
NOMESCO Finland
Excision or incsion of a bone of wrist
+∞
13.6
13
*
ND2CG
NOMESCO Finland
Extensive MRI of hand
51.2
12.9
15
*
9104
FHL
Autogenous bone graft
132.7
12.5
13
*
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.0
12.1
56
200
ND3CG
NOMESCO Finland
Extensive MRI of fingers
66.3
11.6
13
*
ND1BG
NOMESCO Finland
Wrist and hand MRI examination with high intensity magnet
10.3
11.6
22
22
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
35.8
11.3
14
*
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
4.7
10.3
24
53
M67.4
ICD-10 Finland
Ganglion
2.7
10.0
57
227
NDR99
NOMESCO Finland
Other operation for tumour of wrist or hand
+∞
9.4
9
*
SPAT1153
SPAT
Removal of sutures
1.8
9.1
182
1178
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
37.3
9.0
11
*
L12
ICPC
Hand/finger symptom/complaint
2.0
9.0
108
591
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.4
8.9
22
51
M01AH05
ATC
etoricoxib; oral
1.7
8.8
387
3099
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
8.6
274
2009
ZZH20
NOMESCO Finland
Graft of patients own bone
14.7
8.2
13
9
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.4
8.0
20
47
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
7.8
256
1877
ND2AA, ,
SPAT
2.7
7.8
41
157
ND2BG
NOMESCO Finland
MRI of hand
15.3
7.7
12
8
UJF32
NOMESCO Finland
Coloscopy
1.8
7.7
147
932
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
4.0
7.5
21
54
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.0
7.4
32
110
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.4
244
1788
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.9
7.4
35
127
X58
ICD-10 Finland
Exposure to other specified factors
1.9
7.3
95
533
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
7.0
7.3
17
25
D16
ICD-10 Finland
Benign neoplasm of bone and articular cartilage
+∞
7.3
7
*
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
7.2
117
705
ND1DG
NOMESCO Finland
Wrist and hand very extensive MRI examination with high intensity magnet
30.4
7.2
9
*
M54.5
ICD-10 Finland
Low back pain
1.6
7.1
218
1565
ZXA05
NOMESCO Finland
Left side
1.7
7.0
134
850
M25.5
ICD-10 Finland
Pain in joint
1.6
6.8
203
1445
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
3.1
6.7
27
89
A02BC02
ATC
pantoprazole; systemic
1.6
6.7
382
3159
ZZH40
NOMESCO Finland
Substitute of bone
7.0
6.5
15
22
N02BF02
ATC
pregabalin; oral
2.5
6.5
40
166
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
6.4
240
1794
ND1AD
NOMESCO Finland
Wrist CT examination
6.1
6.3
16
27
Q78.48
ICD-10 Finland
Enchondromatosis
+∞
6.3
6
*
P01BA02
ATC
hydroxychloroquine; oral
2.2
6.2
55
268

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
141
878
1.80
7.88
1.3
1.3
12.04
10.15
u/ml
0.12
52
371
271
2021
1.63
7.73
2.1
2.0
—
—
—
0
0
139
905
1.70
6.53
1.4
1.3
21.02
28.83
iu/ml
0.62
38
317
175
1228
1.61
6.08
2.3
2.5
3887.29
5180.08
umol/l
0.17
146
1101
425
3661
1.59
5.74
4.5
3.9
10.03
10.82
mm/h
0.59
396
3394
175
1283
1.52
4.86
3.8
3.4
—
—
—
0
0
422
3724
1.48
4.26
7.1
7.4
72.51
77.67
u/l
3.23
398
3501
145
1071
1.47
3.77
2.4
2.0
2.85
2.98
mg/l
0.24
123
933
425
3794
1.44
3.72
4.1
3.9
14.79
14.58
pmol/l
1.04
396
3495
103
710
1.55
3.72
1.4
1.3
681.60
511.41
titre
0.27
25
149
62
382
1.70
3.52
1.2
1.2
—
—
—
0
0
493
4546
1.53
3.51
5.0
4.6
6.74
2.10
mu/l
0.46
454
4219
235
1917
1.38
3.45
4.4
4.6
36.67
36.16
g/l
0.73
212
1811
372
3280
1.37
3.26
4.4
4.0
—
—
—
0
0
531
5001
1.66
3.21
13.7
13.6
139.74
139.71
mmol/l
0.12
517
4873
532
5015
1.66
3.18
13.9
13.7
3.96
3.95
mmol/l
0.04
515
4880
55
338
1.69
3.17
2.3
2.7
3.82
7.69
e9/l
1.29
44
291
65
419
1.62
3.12
4.2
4.2
—
—
—
0
0
526
4951
1.61
3.08
12.9
12.4
22.08
21.75
mg/l
0.07
433
3828
298
2558
1.34
3.02
5.6
6.0
0.21
0.18
e9/l
1.38
267
2275
309
2670
1.33
2.98
3.6
4.4
6.45
6.62
mmol/l
0.65
289
2498
272
2328
1.31
2.72
6.3
6.3
—
—
—
0
0
87
620
1.47
2.69
1.3
1.2
—
—
—
0
0
99
727
1.44
2.62
1.7
1.7
1068.34
1205.83
nmol/l
1.02
80
548
210
1742
1.32
2.60
1.9
1.9
102.05
96.33
pmol/l
0.83
108
926
291
2527
1.30
2.57
5.7
5.7
2.06
1.93
e9/l
0.38
261
2278
93
678
1.44
2.56
1.2
1.2
—
—
—
0
0
256
2187
1.30
2.55
3.0
2.7
102.34
113.77
ug/l
0.49
230
2044
544
5207
1.62
2.41
12.6
11.6
—
—
—
0
0
185
1521
1.32
2.41
3.0
3.3
2.35
2.35
mmol/l
0.14
161
1367
283
2463
1.29
2.40
5.6
5.7
0.04
0.04
e9/l
0.45
248
2168
15
65
2.34
2.33
1.5
1.2
—
—
—
0
0
282
2460
1.28
2.32
5.7
5.7
0.56
0.56
e9/l
0.03
248
2164
150
1206
1.33
2.28
2.8
2.7
—
—
—
0
0
255
2202
1.28
2.26
5.6
6.5
1.22
1.21
mmol/l
1.23
208
1879
118
917
1.36
2.24
1.4
1.7
501.04
15769664.40
pmol/l
0.78
83
780
32
188
1.74
2.22
1.7
1.2
—
—
—
0
0
232
1986
1.28
2.19
4.6
5.6
1.22
1.21
mmol/l
1.06
208
1816
180
1494
1.30
2.16
2.7
2.4
55.29
60.31
u/l
0.70
156
1390
23
123
1.91
2.14
3.0
2.8
—
—
—
0
0
144
1161
1.32
2.13
1.4
1.3
2.67
1.71
u/ml
0.18
39
335
87
649
1.40
2.12
2.0
2.2
2.40
2.39
g/l
0.05
79
598
87
650
1.40
2.10
2.7
2.5
166.62
118.10
ug/g
0.76
61
520
201
1698
1.28
2.09
2.9
3.2
21.13
33.44
ng/l
0.96
127
1062
5
10
5.03
2.07
1.2
2.0
—
—
—
0
0
257
2241
1.26
2.05
2.4
2.5
—
—
—
0
0
93
706
1.38
2.05
2.0
2.2
14.93
13.72
umol/l
0.81
81
656
105
815
1.35
2.01
3.2
3.6
150.26
400.21
ng/l
1.36
66
576
500
4741
1.37
1.98
4.6
4.2
5.82
5.86
mmol/l
0.36
458
4385
80
596
1.40
1.97
2.1
2.3
25.24
23.45
%
0.52
62
519
81
605
1.39
1.97
1.6
1.6
—
—
—
0
0
501
4759
1.36
1.90
4.0
3.7
1.26
1.30
mmol/l
0.52
457
4439
517
4939
1.40
1.86
4.4
4.2
4.74
4.78
mmol/l
0.43
479
4640
231
2007
1.25
1.86
10.2
10.7
1.12
1.17
inr
0.42
60
628
7
23
3.07
1.80
2.3
3.2
42200.00
37226.30
ug/l
—
7
23
23
131
1.79
1.80
1.2
1.1
—
—
—
0
0
268
2375
1.24
1.78
4.4
4.5
0.00
0.00
estimate
0.50
63
470
268
2378
1.23
1.75
6.1
5.8
28.96
28.48
%
0.31
248
2252
265
2350
1.23
1.74
5.8
5.6
55.60
56.78
%
1.02
245
2224
270
2405
1.23
1.68
3.4
3.3
0.00
0.01
estimate
0.80
57
450
261
2317
1.23
1.68
6.3
6.0
8.38
8.44
%
0.11
241
2189
71
537
1.37
1.62
1.4
1.6
—
—
—
0
0
251
2227
1.22
1.61
6.0
5.8
0.67
0.69
%
0.25
231
2090
135
1119
1.27
1.60
2.2
2.1
—
—
—
0
0
15
77
1.97
1.60
1.4
1.5
—
—
—
0
0
259
2306
1.22
1.60
6.0
5.7
3.05
2.79
%
0.89
239
2169
34
224
1.55
1.58
1.1
1.1
—
—
—
0
0
53
384
1.42
1.56
1.2
1.2
223.17
154.23
iu/ml
0.40
26
158
265
2370
1.22
1.56
3.5
3.3
0.00
0.00
estimate
0.50
63
491
545
5281
1.46
1.54
10.8
9.9
26.18
27.12
u/l
0.78
527
5125
149
1258
1.25
1.51
3.4
3.3
26.51
208.19
mg/l
1.31
95
828
512
4915
1.33
1.51
4.3
4.1
1.49
1.48
mmol/l
0.22
472
4600
125
1035
1.26
1.50
1.5
1.4
2.19
2.30
g/l
0.50
72
666
56
413
1.39
1.50
3.5
3.4
—
—
—
0
0
22
353
0.61
1.50
1.7
1.7
—
—
—
0
0
19
109
1.77
1.48
1.4
1.3
—
—
—
0
0
23
140
1.67
1.47
3.6
2.6
—
—
—
0
0
227
2009
1.21
1.46
2.3
2.3
77.23
75.59
nmol/l
0.38
201
1825
7
28
2.52
1.45
1.7
2.8
—
—
—
0
0
9
39
2.33
1.43
1.4
1.1
—
—
—
0
0
74
576
1.33
1.42
1.6
1.3
—
—
—
0
0
157
1347
1.23
1.37
1.9
2.1
110.46
183.08
u/l
4.41
149
1272
148
1262
1.23
1.37
3.7
3.6
0.00
0.01
estimate
0.88
59
458
0
39
0.00
1.34
0.0
2.7
—
45.72
—
0
23
24
152
1.60
1.34
3.4
3.6
0.17
0.22
g/l
—
9
61
11
54
2.06
1.33
1.5
1.3
—
—
—
0
0
144
1232
1.22
1.29
3.0
2.8
0.40
0.44
e6/l
0.09
111
926
308
2828
1.19
1.28
7.6
9.1
3.76
3.99
e9/l
1.30
267
2499
48
636
0.73
1.27
1.3
1.4
—
—
—
0
0
6
25
2.41
1.24
1.2
1.5
149.50
152.12
nmol/l
—
6
25
57
438
1.33
1.21
2.8
2.1
335.10
366.80
nmol/l
0.66
49
409
519
5020
1.30
1.20
4.8
4.6
2.79
2.86
mmol/l
1.00
478
4695
112
941
1.24
1.19
2.3
2.3
5.34
6.35
e6/l
0.32
95
845
8
38
2.12
1.19
2.6
1.5
1.13
1.35
promille
—
8
28
8
38
2.12
1.19
1.4
1.3
—
—
—
0
0
45
335
1.37
1.17
1.3
1.4
—
—
—
0
0
160
1396
1.20
1.17
3.2
3.2
7.92
7.78
mmol/l
0.11
128
1183
50
379
1.35
1.17
1.2
1.5
—
—
—
0
0
15
87
1.74
1.16
1.6
2.2
129.70
131.76
g/l
—
10
66
13
72
1.82
1.16
1.5
1.4
—
—
—
0
0
31
217
1.45
1.14
2.4
2.3
—
—
—
0
0
155
1353
1.20
1.13
3.0
2.9
87.64
105.31
e6/l
0.08
117
1043
565
5544
1.53
1.12
19.8
18.4
40.65
40.54
%
0.19
532
5250
8
40
2.01
1.12
1.6
2.6
—
—
—
0
0
68
543
1.29
1.11
5.7
5.5
1.04
1.04
mmol/l
0.06
63
511
5
21
2.39
1.09
29.0
20.3
6.64
6.67
ug/l
—
5
15
470
4509
1.21
1.09
5.4
5.2
38.46
39.32
mmol/mol
1.46
426
4238
359
3368
1.17
1.07
3.6
3.4
—
—
—
0
0
565
5548
1.51
1.07
19.9
18.4
258.95
254.07
e9/l
1.01
551
5431
10
52
1.94
1.06
2.0
1.6
—
—
—
0
0
565
5549
1.51
1.05
19.8
18.3
90.94
90.72
fl
0.55
556
5487
46
351
1.34
1.05
3.5
3.4
—
—
—
0
0
565
5550
1.50
1.04
19.8
18.2
30.34
30.26
pg
0.55
556
5487
565
5551
1.50
1.02
19.9
18.3
4.53
4.53
e12/l
0.01
551
5422
565
5552
1.49
1.01
19.9
18.4
6.64
6.58
e9/l
0.21
550
5419
565
5554
1.48
0.98
19.9
18.4
136.82
136.48
g/l
0.25
557
5488
0
30
0.00
0.97
0.0
2.0
—
9.33
—
0
30
141
1239
1.18
0.95
4.4
4.4
1.85
2.23
ug/l
0.58
130
1119
134
1173
1.18
0.94
3.0
3.5
92.91
93.87
%
0.18
129
1143
9
52
1.74
0.92
1.2
1.7
90.02
90.40
%
—
9
52
14
86
1.64
0.91
1.4
2.9
2.26
2.65
mmol/l
—
5
59
36
272
1.34
0.89
3.0
2.5
—
—
—
0
0
177
1594
1.16
0.88
3.3
3.4
51.83
76.78
e6/l
0.49
128
1123
72
598
1.23
0.88
1.3
1.4
—
—
—
0
0
6
30
2.01
0.87
1.5
1.4
—
—
—
0
0
150
1335
1.17
0.87
3.8
3.9
2.91
8.07
mg/mmol
3.52
91
845
16
104
1.55
0.85
1.1
1.1
—
—
—
0
0
16
104
1.55
0.85
1.1
1.1
—
—
—
0
0
26
189
1.39
0.82
2.3
2.2
88.10
3533.20
u/l
—
6
75
14
89
1.59
0.82
1.6
2.6
—
—
—
0
0
45
357
1.28
0.81
2.4
3.7
1.24
1.23
mmol/l
1.05
38
310
55
449
1.25
0.79
2.3
2.9
1.77
1.79
%
0.04
47
409
90
775
1.19
0.78
2.7
2.7
2.42
2.44
mmol/l
1.30
78
688
0
27
0.00
0.77
0.0
4.7
—
—
—
0
0
6
34
1.77
0.76
2.7
1.8
2.00
3.83
mg/l
—
6
34
48
388
1.26
0.76
3.0
2.6
9.50
10.17
g/l
0.64
39
357
6
106
0.56
0.73
5.7
4.3
—
—
—
0
0
9
56
1.62
0.72
1.0
1.3
—
—
nmol/l
—
0
0
38
301
1.28
0.71
1.3
1.4
34.99
27.85
iu/l
0.49
33
255
125
1117
1.15
0.69
1.6
1.7
0.87
1.08
mg/l
0.42
91
863
150
1358
1.14
0.69
3.0
3.0
—
—
—
0
0
119
1061
1.15
0.68
3.5
3.3
—
—
—
0
0
7
119
0.58
0.68
1.0
1.2
—
—
—
0
0
80
692
1.18
0.67
2.7
2.7
2.53
2.78
e6/l
0.09
44
369
110
977
1.15
0.66
1.8
1.8
—
—
—
0
0
15
213
0.70
0.66
4.1
3.2
—
—
—
0
0
12
78
1.55
0.66
1.4
1.4
—
—
—
0
0
22
164
1.35
0.63
1.6
1.6
—
—
—
0
0
162
1483
1.13
0.63
2.2
2.2
—
—
—
0
0
126
1393
0.88
0.63
1.4
1.5
—
—
—
0
0
22
289
0.75
0.61
2.5
2.3
21.02
40.84
u/ml
1.24
22
275
5
30
1.67
0.61
3.2
4.5
24.34
45.19
mu/l
—
5
30
14
196
0.71
0.58
1.6
2.3
0.70
0.65
%
0.25
14
196
110
988
1.14
0.58
1.5
1.5
22.31
20.69
nmol/l
0.41
91
844
6
35
1.72
0.58
1.0
1.1
155.17
223.37
mg/l
—
6
30
124
1124
1.13
0.57
3.3
4.2
—
—
—
0
0
12
172
0.69
0.57
1.3
1.2
—
—
—
0
0
205
1914
1.11
0.56
3.3
3.1
5.88
5.76
ph
0.26
17
190
11
73
1.52
0.56
1.3
1.2
22.87
15.60
u/l
0.26
11
61
5
89
0.56
0.56
1.6
2.3
—
—
—
0
0
6
37
1.63
0.55
1.2
1.3
30.33
32.56
g/l
—
6
32
63
545
1.17
0.55
1.8
2.6
7.33
7.38
umol/l
0.01
50
475
25
316
0.78
0.54
2.7
2.5
4.32
4.85
kpa
0.72
25
306
41
341
1.22
0.54
1.8
2.3
3.43
7.92
ug/l
3.01
33
310
9
61
1.48
0.54
1.0
1.3
—
—
—
0
0
6
39
1.54
0.53
1.0
1.1
—
—
—
0
0
16
117
1.38
0.52
2.0
2.1
34.45
127.03
ug/min
—
8
66
9
64
1.41
0.51
1.0
1.3
0.53
0.55
nmol/l
—
9
59
44
518
0.84
0.51
4.7
6.6
104.64
104.11
mmol/l
0.43
44
518
7
45
1.56
0.49
1.0
1.2
—
—
—
0
0
7
46
1.53
0.48
8.4
2.3
—
—
—
0
0
7
47
1.50
0.47
1.0
1.2
—
—
—
0
0
141
1303
1.11
0.47
2.8
2.7
—
—
—
0
0
7
48
1.46
0.47
4.6
1.4
—
—
—
0
0
47
404
1.18
0.46
1.3
1.4
—
—
—
0
0
12
86
1.40
0.44
2.0
2.4
16.13
16.58
%
—
6
45
7
51
1.38
0.44
1.0
1.3
—
—
—
0
0
24
193
1.25
0.44
1.6
1.6
—
—
—
0
0
8
56
1.43
0.42
1.9
2.6
—
—
—
0
0
12
87
1.39
0.42
1.2
1.7
—
—
—
0
0
19
149
1.28
0.42
1.1
1.2
—
—
—
0
0
34
287
1.20
0.41
1.2
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
14
106
1.33
0.39
1.0
1.3
—
—
—
0
0
97
889
1.11
0.39
2.8
2.6
532.30
545.68
mosm/kgh2o
0.21
80
763
110
1016
1.10
0.38
3.9
3.5
1.02
1.02
kg/l
0.19
20
128
9
67
1.35
0.38
1.4
1.3
—
30.14
—
0
5
51
450
1.15
0.37
3.8
7.9
4.95
5.17
kpa
1.32
46
434
51
450
1.15
0.37
3.8
7.9
11.81
12.41
kpa
0.45
46
436
230
2196
1.08
0.37
8.2
8.5
0.00
0.00
e9/l
0.58
189
1806
17
213
0.79
0.37
1.1
1.5
—
—
—
0
0
9
70
1.29
0.36
1.2
1.1
—
—
—
0
0
17
212
0.80
0.36
1.1
1.5
—
—
—
0
0
17
212
0.80
0.36
1.1
1.5
—
—
—
0
0
51
452
1.14
0.36
3.7
7.9
0.87
1.28
mmol/l
0.48
39
370
6
42
1.43
0.35
2.7
2.2
—
—
—
0
0
17
211
0.80
0.35
1.1
1.5
—
—
—
0
0
6
45
1.34
0.34
3.0
2.2
—
—
—
0
0
11
144
0.76
0.33
1.2
1.9
—
—
—
0
0
12
155
0.77
0.33
9.7
7.3
—
—
—
0
0
20
242
0.82
0.33
2.5
2.6
0.05
0.12
e6/l
0.86
20
234
142
1339
1.08
0.32
3.7
3.9
7.40
7.40
ph
0.40
34
253
38
333
1.15
0.32
4.4
8.0
—
—
—
0
0
22
184
1.20
0.31
1.2
1.3
147.82
238.16
miu/ml
—
10
89
7
55
1.28
0.30
1.1
1.1
—
—
—
0
0
26
222
1.18
0.30
3.6
9.1
—
—
—
0
0
258
2493
1.06
0.29
5.4
6.2
11.51
10.67
umol/l
0.27
237
2364
24
205
1.18
0.28
3.8
2.9
—
—
—
0
0
31
271
1.15
0.27
1.1
1.1
—
—
—
0
0
36
319
1.14
0.27
2.7
2.9
72.40
73.17
e9/l
0.05
28
236
34
383
0.88
0.26
2.4
3.2
6.07
5.76
kpa
1.29
34
373
5
71
0.70
0.26
1.2
1.1
2.42
4.34
u/ml
—
5
22
5
72
0.69
0.26
1.4
1.7
47.20
64.45
%
—
5
72
5
74
0.67
0.26
1.0
1.1
—
98.33
—
0
18
29
254
1.15
0.25
2.3
5.0
—
—
—
0
0
35
391
0.89
0.24
1.4
1.4
—
—
—
0
0
175
1680
1.06
0.24
2.9
3.3
28.66
31.66
u/l
1.02
162
1608
6
81
0.74
0.24
1.3
1.6
—
—
—
0
0
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
11
88
1.25
0.22
1.5
1.2
—
—
—
0
0
18
153
1.18
0.22
1.1
1.2
—
—
—
0
0
7
94
0.74
0.22
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
1.08
1.04
g/l
—
5
41
85
800
1.07
0.21
1.7
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
1.81
—
0
10
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
2.8
1.5
90.80
72.12
umol/l
—
5
43
11
134
0.82
0.21
1.7
1.3
—
—
—
0
0
57
529
1.09
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
14
118
1.19
0.19
4.6
3.7
26.71
89.86
mg/l
0.62
14
95
14
118
1.19
0.19
4.6
3.7
27.77
27.94
mg/l
0.01
14
94
6
52
1.16
0.19
1.0
1.3
—
—
—
0
0
17
196
0.86
0.19
1.1
1.5
—
—
—
0
0
12
142
0.84
0.17
2.3
2.4
11.38
11.31
mg/l
0.01
12
133
10
82
1.22
0.17
1.3
1.1
—
—
—
0
0
355
3496
1.04
0.16
3.4
3.1
43.57
46.30
u/l
0.32
324
3302
35
322
1.09
0.16
1.2
1.2
—
—
—
0
0
9
78
1.16
0.15
1.4
1.8
—
—
—
0
0
35
379
0.92
0.15
2.6
3.3
1.87
1.91
mmol/l
0.02
30
308
31
284
1.10
0.15
2.8
2.6
—
—
—
0
0
9
82
1.10
0.15
2.8
2.4
—
—
—
0
0
46
431
1.07
0.14
4.1
4.3
13.59
18.92
ug/l
0.16
38
355
21
190
1.11
0.13
2.2
3.0
24.14
24.11
mmol/l
0.02
21
185
30
279
1.08
0.11
3.8
3.0
7.45
7.40
ph
—
6
37
10
86
1.17
0.11
5.6
4.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
126
1292
0.97
0.10
1.6
1.7
1.52
1.43
mmol/l
0.29
110
1099
56
583
0.96
0.09
1.7
1.4
—
—
—
0
0
38
400
0.95
0.09
4.1
3.9
0.20
0.72
%
1.97
15
129
7
64
1.09
0.08
1.4
1.1
—
—
—
0
0
438
4352
1.03
0.08
13.7
14.8
15.47
14.56
%
1.94
431
4286
33
313
1.06
0.08
1.8
1.8
1.80
1.30
g/l
0.38
27
292
6
74
0.81
0.07
1.2
1.1
—
—
—
0
0
8
76
1.05
0.07
3.6
3.3
0.13
1.11
%
—
8
70
14
153
0.91
0.07
2.1
4.4
—
—
—
0
0
9
84
1.07
0.07
1.0
1.0
—
—
—
0
0
13
118
1.10
0.07
1.0
1.2
3.26
3.72
mmol/l
3.53
13
110
123
1206
1.03
0.07
6.0
6.5
—
—
—
0
0
9
101
0.89
0.06
4.4
3.6
4.34
4.25
e9/l
—
9
101
9
104
0.86
0.06
4.4
3.9
60.22
56.69
%
—
9
104
12
109
1.10
0.06
3.0
2.2
—
—
—
0
0
50
515
0.97
0.05
1.9
1.6
—
—
—
0
0
57
557
1.03
0.04
1.5
1.7
—
—
—
0
0
72
733
0.98
0.03
2.8
2.8
0.58
0.72
ug/l
1.82
50
451
42
409
1.03
0.03
4.0
4.1
0.07
0.17
%
0.66
15
126
67
658
1.02
0.03
1.9
2.0
—
—
—
0
0
10
108
0.92
0.03
1.3
1.4
—
—
—
0
0
40
390
1.03
0.03
3.9
4.1
0.00
0.16
%
1.03
13
106
43
438
0.98
0.01
4.0
4.0
1.00
1.13
%
0.13
16
156
204
2031
1.01
0.01
2.6
2.6
—
—
—
0
0
10
94
1.06
0.01
1.7
1.9
5.42
5.07
mmol/24h
—
10
80
12
126
0.95
0.00
1.8
2.0
6.67
5.93
iu/l
—
6
46
11
107
1.03
0.00
2.9
2.3
8.48
8.30
kpa
0.15
11
107
16
163
0.98
0.00
1.1
1.5
—
—
—
0
0
10
99
1.01
0.00
1.6
1.7
—
—
—
0
0
8
82
0.98
-0.00
1.8
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
55
0.91
-0.00
4.0
4.3
—
—
—
0
0
7
71
0.99
-0.00
1.0
1.1
1.39
1.44
g/l
—
7
64
0
9
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
34.26
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.7
—
—
—
0
0
9
94
0.96
-0.00
1.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.8
—
0.29
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
38.57
—
0
7
0
7
0.00
-0.00
0.0
2.3
—
67.86
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
54
0.93
-0.00
3.2
1.9
35.40
32.93
pg
—
5
54
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
2.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
15.93
—
0
5
0
8
0.00
-0.00
0.0
4.5
—
—
—
0
0
6
60
1.00
-0.00
1.3
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BONE_SHORT_UPPER and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BONE_SHORT_UPPER 0.944 [0.72, 1.23] 0.672
Birth year 0.997 [0.99, 1.01] 0.516

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1306 females with CD2_BENIGN_BONE_SHORT_UPPER died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_BONE_SHORT_UPPER 1.044 [0.83, 1.31] 0.71
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 1186 males with CD2_BENIGN_BONE_SHORT_UPPER died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BONE_SHORT_UPPER.

N-year risk Females Males
1 0.111% 0.233%
5 0.545% 1.21%
10 1.497% 3.125%
15 2.917% 5.91%
20 5.199% 10.258%

Relationships between endpoints

Index endpoint: CD2_BENIGN_BONE_SHORT_UPPER – Benign neoplasm: Short bones of upper limb

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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