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Carcinoma in situ of skin of scalp and neck

CD2_INSITU_SKIN_SCALPNECK

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D04.4&
  • Hospital discharge: ICD-9 2324
  • Cause of death: ICD-10 D04.4&
  • Cause of death: ICD-9 2324

2 out of 7 registries used, show all original rules.

739

4. Check minimum number of events

None

739

5. Include endpoints

None

739

6. Filter based on genotype QC (FinnGen only)

739

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D04
Name in latin
Carcinoma in situ cutis verticis cranii

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 739 205 534
Unadjusted period prevalence (%) 0.19 0.07 0.24
Median age at first event (years) 78.01 77.79 78.10

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
629
Matched controls
6291
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
4503599627370496.0
323.0
626
*
L57.0
ICD-10 Finland
Actinic keratosis
50.8
323.0
527
580
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
21.1
222.8
379
421
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
41.2
180.9
229
86
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
15.1
173.4
335
442
TQW99
NOMESCO Finland
Other minor procedure on skin
21.2
163.3
257
198
ZXC50
NOMESCO Finland
Cryotherapy
19.9
118.7
187
131
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
31.9
111.9
150
61
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
12.7
109.1
212
241
R23.8
ICD-10 Finland
Other and unspecified skin changes
8.0
107.5
299
637
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
18.9
106.3
170
121
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
18.1
104.0
169
125
D06BB10
ATC
imiquimod; topical
16.0
103.2
177
150
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
8.7
88.4
216
357
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
19.3
78.7
123
78
ZXC15
NOMESCO Finland
Use of photodynamic technique
25.2
77.8
111
53
ZXC20
NOMESCO Finland
Use of chemical agents
19.5
77.6
121
76
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
75.3
75.6
85
13
S18
ICPC
Laceration/cut
4.5
67.2
433
2076
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
10.1
61.2
129
156
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
7.4
58.1
151
256
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
16.3
56.9
94
67
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
24.6
56.1
80
37
ZQZ00
NOMESCO Finland
Treatment of several skin areas
39.9
54.1
68
19
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
32.1
52.2
69
24
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
17.0
48.2
78
52
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
5.5
44.8
147
329
ZZR00
NOMESCO Finland
Flap of skin
12.1
43.7
82
77
Z2221
NOMESCO Finland
Medical doctor
3.5
43.4
269
1096
XQ848
NOMESCO Finland
Dermatological photography
10.2
40.1
82
91
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
31.3
39.3
52
18
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
9.6
36.0
76
89
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
59.2
33.6
39
7
ZXE10
NOMESCO Finland
More than one and less than three hours
2.8
32.6
317
1669
A98
ICPC
Health maint/preventive medicine
5.4
32.2
595
4799
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.9
32.0
70
87
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
13.0
30.8
55
46
L82
ICD-10 Finland
Seborrhoeic keratosis
3.4
30.8
179
662
R4110
NOMESCO Finland
Physiotherapy
2.9
30.1
237
1078
ZXE00
NOMESCO Finland
One hour or less
2.6
29.1
312
1703
SPAT1153
SPAT
Removal of sutures
2.6
28.8
303
1635
127
Kela drug reimbursment
Transplant complication
21.8
28.2
41
20
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
23.6
28.2
40
18
WX110
NOMESCO Finland
Local anesthesy
2.6
27.7
424
2792
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
8.1
27.4
63
85
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
21.7
25.5
37
18
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
25.4
312
1790
S21
ICPC
Skin texture symptom/complaint
3.4
25.3
141
495
Z3231
NOMESCO Finland
Registered nurse
2.6
25.1
251
1283
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
10.9
24.5
47
46
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
20.0
24.2
36
19
WX002
NOMESCO Finland
Sedation and analgesia
2.8
24.1
187
819
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
15.9
24.1
39
26
E0000UV
ATC
NA
2.4
22.7
282
1597
S29
ICPC
Skin symptom/complaint other
2.9
22.3
159
658
J01DB01
ATC
cefalexin; oral
2.6
21.6
516
3992
TQW80
NOMESCO Finland
Local dermatologic skincare
7.6
21.5
51
72
Z94.0
ICD-10 Finland
Kidney transplant status
24.1
21.4
30
13
Z3226
NOMESCO Finland
Physiotherapist
2.8
21.2
164
710
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
62.2
21.0
24
*
8070/3-C44.4
ICD-O-3
Squamous cell carcinoma, NOS, of skin of scalp and neck
62.2
21.0
24
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
20.9
213
1078
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
5.7
20.7
61
116
L04AD01
ATC
ciclosporin; systemic
11.5
20.4
38
35
L04AA06
ATC
mycophenolic acid; systemic
15.1
20.1
33
23
D06BX02
ATC
ingenol mebutate; topical
7.9
20.0
46
62
DAB00
NOMESCO Finland
Excision of lesion of auricle
10.9
19.9
38
37
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
30.0
19.8
26
9
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
18.5
19.7
30
17
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
15.3
19.6
32
22
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.9
19.2
65
145
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
4.5
19.2
70
169
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
8.7
19.0
41
50
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
8.4
18.6
41
52
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
14.2
17.9
30
22
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.0
17.8
74
202
C44.40
ICD-10 Finland
Malignant tumor of the skin of the scalp and neck without histology
68.6
17.8
20
*
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
15.1
17.8
29
20
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.2
17.3
42
62
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
17.0
359
2464
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
16.6
182
938
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
20.7
16.5
24
12
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.5
15.8
137
624
XQ845
NOMESCO Finland
Dermatoscopy
7.1
15.2
37
55
Z71.8
ICD-10 Finland
Other specified counselling
2.3
14.9
152
751
ZZA00
NOMESCO Finland
Split skin graft
4.6
14.8
52
121
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
14.9
14.1
23
16
N02BE01
ATC
paracetamol; systemic, rectal
2.4
14.1
546
4618
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
13.7
66
204
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
8.6
13.6
29
35
A11CC03
ATC
alfacalcidol; systemic
6.4
13.5
35
57
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
11.8
13.4
24
21
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
14.2
13.3
22
16
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
4.7
13.1
44
98
A12AA04
ATC
calcium carbonate; oral
7.9
13.0
29
38
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
4.7
12.9
44
100
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.1
12.7
163
887
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
15.8
12.7
20
13
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
5.8
12.6
35
63
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
9.9
12.3
24
25
B07.9
ICD-10 Finland
Verruca simplex
5.5
12.3
36
69
J01CA04
ATC
amoxicillin; systemic
1.9
12.3
460
3684
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
12.1
134
681
DHB00
NOMESCO Finland
Excision of lesion of external nose
8.9
12.1
25
29
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
18.5
12.1
18
10
ZXA00
NOMESCO Finland
Right side
1.9
11.7
217
1356
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.4
11.5
34
66
DAB10
NOMESCO Finland
Partial excision of auricle
12.1
11.4
20
17
ZZA50
NOMESCO Finland
Full thickness skin graft
12.1
11.4
20
17
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.7
11.2
49
141
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.1
11.1
148
813
D07AB08
ATC
desonide; topical
2.6
11.1
85
358
M79.6
ICD-10 Finland
Pain in limb
1.9
11.0
223
1436
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
4.1
10.8
42
109
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
10.6
110
541
ZXD05
NOMESCO Finland
Urgent procedure
1.9
10.6
217
1393
TQW40
SPAT
NA
4.9
10.6
34
73
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
9.4
10.6
21
23
C08CA01
ATC
amlodipine; oral
1.8
10.4
299
2143
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
9.8
10.3
20
21
L04AA01
ATC
[U] ciclosporin; systemic
6.1
10.2
27
46
L04AX01
ATC
azathioprine; systemic
4.1
10.1
38
96
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.6
10.1
34
77
L57
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation
40.7
10.0
12
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
4.4
9.9
35
83
137
Kela drug reimbursment
Uraemia requiring dialysis
12.4
9.9
17
14
Z49.0
ICD-10 Finland
Preparatory care for dialysis
10.9
9.8
18
17
TK800
NOMESCO Finland
Hemodialysis
5.5
9.8
28
53
C44.72
ICD-10 Finland
Spinocellular carcinoma of the skin of the lower extremity including the hip
13.6
9.7
16
12
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.0
9.7
21
27
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
6.5
9.6
24
38
QAE99
SPAT
NA
15.3
9.5
15
10
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
9.5
276
1969
S77
ICPC
Malignant neoplasm of skin
5.5
9.5
27
51
C44.49
ICD-10 Finland
Malignant tumor of the skin of the scalp and of the neck other or unspecified histology
30.5
9.4
12
*
WXQ41
NOMESCO Finland
Photodynamic therapy of head and neck
30.5
9.4
12
*
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
12.6
9.4
16
13
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
9.2
156
933
205
Kela drug reimbursment
Chronic hypertension
1.7
9.2
266
1889
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
11.7
9.1
16
14
TQW40
NOMESCO Finland
Remowal of suture of skin
2.8
9.0
57
215
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
24.4
8.9
12
5
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
8.9
176
1108
M79.1
ICD-10 Finland
Myalgia
2.4
8.8
74
326
D06BX01
ATC
metronidazole; topical
2.6
8.6
64
264
L85.80
ICD-10 Finland
Hudhorn
10.2
8.6
16
16
D07AC01
ATC
betamethasone; topical
1.7
8.5
224
1535
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
27.9
8.5
11
*
ZXC10
NOMESCO Finland
Use of laser
5.0
8.5
26
54
D04
ICD-10 Finland
Carcinoma in situ of skin
+∞
8.3
8
*
UJF32
NOMESCO Finland
Coloscopy
1.7
8.2
193
1279
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
17.4
8.1
12
7
ZXA05
NOMESCO Finland
Left side
1.7
8.1
189
1247
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
8.0
115
643
S15
ICPC
Foreign body in skin
2.7
8.0
54
211
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.3
8.0
74
344
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
7.9
164
1042
ZY010
NOMESCO Finland
Hospital outpatient
4.1
7.9
29
73
XW000
NOMESCO Finland
Bone marrow biopsy
2.9
7.8
46
166
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
45.5
7.7
9
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
7.7
73
344
B01AB10
ATC
tinzaparin; parenteral
2.5
7.7
60
257
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.6
213
1475
D07XC01
ATC
betamethasone, combinations; topical
2.0
7.6
95
504
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
7.2
7.5
17
24
ZXA10
NOMESCO Finland
Bilateral
1.8
7.5
147
917
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.5
199
1360
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.7
7.4
48
185
Z49.2
ICD-10 Finland
Other dialysis
11.0
7.3
13
12
S82
ICPC
Naevus/mole
2.1
7.3
83
423
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.4
7.2
16
22
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
7.2
122
726
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
20.3
7.1
10
5
Z2446
NOMESCO Finland
Social worker
2.8
7.1
45
171
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.6
7.0
251
1850
C09CA01
ATC
losartan; oral
1.7
7.0
177
1189
WX320
NOMESCO Finland
Spinalanesthesy
1.7
6.9
158
1029
ZXD20
NOMESCO Finland
Day surgery
2.1
6.9
84
438
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
6.9
134
830
C44
ICD-10 Finland
Other malignant neoplasms of skin
14.0
6.9
11
8
R4120
NOMESCO Finland
Occupational therapy
2.8
6.9
44
167
R60.0
ICD-10 Finland
Localized oedema
2.0
6.9
92
501
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
8.4
6.9
14
17
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
6.8
64
299
C44.10
ICD-10 Finland
Malignant tumor of the skin of the eyelids including the corner of the eye without histology
11.1
6.8
12
11
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
6.2
6.8
17
28
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
16.9
6.8
10
6
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
16.9
6.8
10
6
Z02.4
ICD-10 Finland
Examination for driving licence
1.6
6.7
220
1578
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.8
6.7
41
153
SPAT1325
SPAT
Vaccination
1.6
6.7
263
1976
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
6.0
6.6
17
29
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
6.0
6.6
17
29
WX402
NOMESCO Finland
General anaesthesia
2.0
6.6
88
478
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
4.4
6.6
22
51
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
6.6
326
2585
D02AE01
ATC
carbamide; topical
2.5
6.6
47
193
B05DA
ATC
Isotonic solutions
10.2
6.6
12
12
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
6.5
69
342
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
3.3
6.5
30
93
3AC01
NOMESCO Finland
NA
6.6
6.4
15
23
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.6
6.4
201
1425
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
6.3
260
1966
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
0.4
6.3
29
656
Z94.4
ICD-10 Finland
Liver transplant status
26.9
6.2
8
*
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
4.6
6.2
20
45
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.7
6.2
158
1058
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
6.2
247
1856
X57
ICD-10 Finland
Unspecified privation
4.3
6.2
21
50
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.0
6.2
35
123
L17
ICPC
Foot/toe symptom/complaint
1.7
6.1
158
1062
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
6.1
57
265
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.0
6.1
32
109
ZX120
NOMESCO Finland
Intravenous
2.0
6.1
73
382
J01FA10
ATC
azithromycin; systemic
1.5
6.1
246
1851
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.1
436
3731
C02EA02
ATC
NA
2.2
6.1
57
268

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_SKIN_SCALPNECK – Carcinoma in situ of skin of scalp and neck

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).