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Hypersomnia

EFO Endpoint Browser PheWeb

F5_HYPERSOMNIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

536

4. Check minimum number of events

None

536

5. Include endpoints

None

536

6. Filter based on genotype QC (FinnGen only)

525

Control definitions (FinnGen only)

Control exclude
F5_SLEEP

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2929 1404 1508
Only index persons 2812 1368 1444
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.06
Median age at first event (years)
Whole population 43.74 39.88 47.34
Only index persons 43.55 39.80 47.10

-FinnGen-

Key figures

All Female Male
Number of individuals 525 308 217
Unadjusted period prevalence (%) 0.11 0.11 0.10
Median age at first event (years) 44.89 42.20 48.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
536
Matched controls
5360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G47.1
ICD-10 Finland
Disorders of excessive somnolence [hypersomnias]
13780.6
307.7
422
*
F51.1
ICD-10 Finland
Nonorganic hypersomnia
+∞
135.3
124
*
G47.3
ICD-10 Finland
Sleep apnoea
8.0
131.6
302
744
G47.9
ICD-10 Finland
Sleep disorder, unspecified
22.3
107.1
82
43
F51.0
ICD-10 Finland
Nonorganic insomnia
+∞
101.3
94
*
R06.5
ICD-10 Finland
Mouth breathing
7.1
77.2
137
246
N06AX12
ATC
bupropion; oral
6.6
58.6
107
195
N06AX16
ATC
venlafaxine; oral
4.9
58.2
162
432
N06BA07
ATC
modafinil; oral
94.6
54.1
59
7
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.9
52.5
143
372
R53
ICD-10 Finland
Malaise and fatigue
4.0
51.2
213
759
N06AX11
ATC
mirtazapine; oral
3.8
50.4
245
968
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
12.4
49.8
51
45
N06BA04
ATC
methylphenidate; oral
8.3
48.6
68
92
N06AB04
ATC
citalopram; systemic
3.9
44.5
175
592
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
6.1
40.0
76
142
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.6
39.1
82
168
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.0
37.2
71
133
N06AB06
ATC
sertraline; oral
4.2
36.7
117
337
R5140
NOMESCO Finland
Monitoring the use of the aid
4.3
36.6
111
308
N05AH04
ATC
quetiapine; oral
3.6
33.8
143
498
N04BC05
ATC
pramipexole; oral
5.1
31.9
73
161
N06AX21
ATC
duloxetine; oral
3.9
31.2
109
333
G47.4
ICD-10 Finland
Narcolepsy and cataplexy
117.0
31.0
33
*
N06AB10
ATC
escitalopram; oral
3.1
30.2
171
706
P03
ICPC
Feeling depressed
4.0
29.7
98
287
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
28.8
173
736
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.2
28.4
83
222
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.8
28.1
100
308
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.7
27.3
54
104
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.9
26.2
87
255
N06AB03
ATC
fluoxetine; oral
3.5
25.8
103
341
TAB00
NOMESCO Finland
Lumbar puncture
4.9
24.2
57
128
N06AX03
ATC
mianserin; oral
6.0
23.9
44
79
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.9
23.7
55
122
N03AX09
ATC
lamotrigine; oral
4.7
23.1
57
133
G47.0
ICD-10 Finland
Disorders of initiating and maintaining sleep [insomnias]
+∞
23.1
22
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.3
22.1
98
345
P06
ICPC
Sleep disturbance
3.4
21.6
86
283
N06AG02
ATC
moclobemide; oral
5.2
21.2
45
92
R06.0
ICD-10 Finland
Dyspnoea
2.6
21.2
169
814
N03AX16
ATC
[U] pregabalin
2.6
20.8
151
694
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
7.0
20.6
32
48
N06AA09
ATC
amitriptyline; systemic
3.7
20.5
70
208
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.1
20.2
95
345
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.4
19.9
80
264
N06AX26
ATC
vortioxetine; oral
3.8
19.9
65
187
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.6
19.2
67
202
R40.0
ICD-10 Finland
Somnolence
72.6
18.8
21
*
M54.5
ICD-10 Finland
Low back pain
2.3
18.5
221
1261
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
18.4
125
553
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
17.9
174
907
N06AX22
ATC
agomelatine; oral
7.7
17.5
25
34
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.9
17.5
32
57
A04
ICPC
Weakness/tiredness general
2.8
16.9
97
392
F34.1
ICD-10 Finland
Dysthymia
4.8
16.8
39
86
N05BA04
ATC
oxazepam; oral
2.4
16.4
151
764
N05CF02
ATC
zolpidem; oral
2.6
16.3
108
469
H03AA01
ATC
levothyroxine sodium; systemic
2.4
16.3
148
745
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
16.1
253
1587
J45.1
ICD-10 Finland
Nonallergic asthma
3.6
16.1
56
168
F31.8
ICD-10 Finland
Other bipolar affective disorders
6.4
16.1
27
44
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.3
15.9
33
66
J46
ICD-10 Finland
Status asthmaticus
6.9
15.9
25
38
P76
ICPC
Depressive disorder
3.4
15.7
60
191
P29
ICPC
Psychological sympt/compl other
3.4
15.7
60
191
N06AB05
ATC
paroxetine; oral
3.8
15.7
50
141
R03DC03
ATC
montelukast; oral
2.5
15.7
113
511
G47.2
ICD-10 Finland
Disorders of the sleep-wake schedule
87.7
15.6
17
*
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.8
15.6
49
137
J45
ICD-10 Finland
Asthma
3.1
15.5
72
258
R03AC02
ATC
salbutamol; inhalant
2.1
15.5
325
2262
F43.1
ICD-10 Finland
Post-traumatic stress disorder
5.2
15.2
32
65
N05CF01
ATC
zopiclone; oral
2.2
15.1
167
908
N03AX12
ATC
[U] gabapentin; oral
2.5
15.1
112
512
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
5.1
14.9
32
66
L03
ICPC
Low back symptom/complaint
2.2
14.8
166
908
R51.80
ICD-10 Finland
Headache
2.4
14.6
113
527
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
14.6
159
859
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
14.5
219
1339
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.9
14.5
74
280
A02BC05
ATC
esomeprazole; systemic
2.1
14.3
231
1446
N06AX05
ATC
trazodone; oral
6.6
14.2
23
36
Z2445
NOMESCO Finland
Psychologist
3.9
14.1
42
113
C07AA05
ATC
propranolol; systemic
2.3
14.1
132
669
N05AX12
ATC
aripiprazole; systemic
4.0
14.0
41
109
R03BB04
ATC
tiotropium bromide; inhalant
3.1
14.0
63
222
N06AX18
ATC
reboxetine; oral
14.1
13.8
23
17
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.3
13.6
119
584
H02AB06
ATC
prednisolone; systemic
2.0
13.5
265
1767
L28
ICPC
Limited function/disability (L)
2.6
13.5
90
390
214
Kela drug reimbursment
Severe and chronic narcolepsy
143.5
13.5
14
*
XA420
NOMESCO Finland
Extensive sleep examination
11.9
13.4
24
21
F60.5
ICD-10 Finland
Anankastic personality disorder
12.6
13.2
23
19
AA1AD
NOMESCO Finland
CT of head and brain
2.2
13.1
142
761
N05AA02
ATC
levomepromazine; systemic
4.5
13.0
32
74
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
13.0
155
861
SPAT1240
SPAT
Therapeutic discussion
2.7
12.9
75
303
A02BC01
ATC
omeprazole; systemic
2.1
12.9
158
887
N05BA01
ATC
diazepam; systemic, rectal
2.6
12.8
80
336
N02AX02
ATC
tramadol; systemic, rectal
2.0
12.8
233
1508
N03AG01
ATC
valproic acid; systemic, rectal
3.3
12.7
50
162
E66.8
ICD-10 Finland
Other obesity
3.4
12.6
46
142
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.5
12.6
31
72
M79.7
ICD-10 Finland
Fibromyalgia
4.7
12.5
29
64
A02BC03
ATC
lansoprazole; oral
2.1
12.5
159
905
R02
ICPC
Shortness of breath/dyspnoea
2.7
12.3
74
304
R96
ICPC
Asthma
2.8
12.3
64
244
L01
ICPC
Neck symptom/complaint
2.4
12.3
97
454
N05CD07
ATC
temazepam; oral
3.0
12.2
57
205
A02BC02
ATC
pantoprazole; systemic
2.0
12.0
357
2701
ZY010
NOMESCO Finland
Hospital outpatient
3.3
11.9
47
153
R01AD09
ATC
mometasone; nasal
1.9
11.7
269
1864
F32.1
ICD-10 Finland
Moderate depressive episode
3.1
11.7
51
176
R03CA02
ATC
ephedrine; oral
66.4
11.6
13
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
11.6
158
918
EB1MA
NOMESCO Finland
Cephalometry with X-ray
5.3
11.4
23
45
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.7
11.3
37
106
E66.01
ICD-10 Finland
Obesity due to excess calories
2.7
11.3
65
261
N05AN01
ATC
lithium; oral
5.1
11.3
24
49
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
11.2
244
1655
J01AA02
ATC
doxycycline; systemic
2.1
11.2
411
3299
-, ,
ICD-10 Finland
5.4
11.1
22
42
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
5.9
11.1
20
35
F40.1
ICD-10 Finland
Social phobias
4.7
11.1
26
58
P01
ICPC
Feeling anxious/nervous/tense
2.4
10.9
85
395
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.6
10.9
68
285
R03BA01
ATC
beclometasone; inhalant
2.4
10.8
83
383
R35
ICD-10 Finland
Polyuria
3.1
10.7
46
157
C07AB07
ATC
bisoprolol; oral
1.9
10.7
230
1546
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
10.7
69
293
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
10.7
88
419
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.8
10.6
56
215
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
5.0
10.6
23
48
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
10.5
197
1267
E66.00
ICD-10 Finland
Metabolic syndrome
3.2
10.4
42
138
DJD20
NOMESCO Finland
Plastic repair of septum of nose
3.7
10.4
33
93
M79.6
ICD-10 Finland
Pain in limb
1.8
10.4
228
1541
N03AE01
ATC
clonazepam; systemic
3.4
10.3
38
118
A02BA02
ATC
ranitidine; systemic
2.2
10.3
99
502
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
3.9
10.3
31
84
G47.8
ICD-10 Finland
Other sleep disorders
8.1
10.2
22
28
R42
ICD-10 Finland
Dizziness and giddiness
2.1
10.2
116
628
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.9
10.2
30
80
N05BA12
ATC
alprazolam; oral
2.6
10.1
60
245
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.2
10.0
41
136
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.5
10.0
67
290
N02BF01
ATC
gabapentin; oral
2.8
9.9
52
199
SPAT1263
SPAT
Sampling
1.8
9.9
229
1566
N04BD01
ATC
selegiline; oral
9.8
9.8
19
20
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
9.8
298
2207
R05FA02
ATC
opium derivatives and expectorants; systemic
1.8
9.7
208
1388
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.4
9.7
24
56
WX722
NOMESCO Finland
PEEP
3.3
9.6
36
113
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
4.2
9.6
26
65
N05AX08
ATC
risperidone; systemic
2.8
9.6
50
191
J34.2
ICD-10 Finland
Deviated nasal septum
3.0
9.5
43
152
R51
ICD-10 Finland
Headache
3.1
9.5
41
141
IAB13
NOMESCO Finland
Psychiatric sleep disorder consultation
101.8
9.4
10
*
R01AD08
ATC
fluticasone; nasal
1.9
9.4
164
1024
M03BX02
ATC
tizanidine; oral
1.8
9.3
338
2619
R03BA08
ATC
ciclesonide; inhalant
2.5
9.2
58
244
R03BA05
ATC
fluticasone; inhalant
2.0
9.2
109
598
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.7
9.1
21
46
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.7
9.1
50
196
SPAT1058
SPAT
PEF monitoring instruction
2.7
9.1
50
196
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
9.1
237
1667
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
9.1
57
239
Z3231
NOMESCO Finland
Registered nurse
1.9
9.1
147
896
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
9.1
201
1349
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.1
9.0
39
134
SAA01
NOMESCO Finland
Simple examination of mouth
1.9
9.0
401
3287
Z2446
NOMESCO Finland
Social worker
2.8
8.9
47
180
SPAT1301
SPAT
No procedures
1.8
8.9
165
1047
G93.3
ICD-10 Finland
Postviral fatigue syndrome
24.5
8.9
12
5
R06AX27
ATC
desloratadine; oral
1.8
8.9
169
1081
WX780
NOMESCO Finland
Remote monitoring CPAP
3.3
8.9
33
103
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
4.6
8.9
21
47
R06AE07
ATC
cetirizine; oral
1.7
8.9
239
1694
N06AX17
ATC
milnacipran; oral
9.7
8.8
17
18
F90.0
ICD-10 Finland
Disturbance of activity and attention
3.3
8.8
33
104
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.3
8.7
70
329
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
8.7
390
3185
F33
ICD-10 Finland
Recurrent depressive disorder
4.9
8.6
19
40
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
4.9
8.6
19
40
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
8.6
213
1469
N02BE01
ATC
paracetamol; systemic, rectal
2.3
8.6
473
4124
N05AH03
ATC
olanzapine; systemic
2.8
8.6
44
166
R01AD01
ATC
beclometasone; nasal
2.1
8.6
93
492
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.8
8.5
26
71
R55
ICD-10 Finland
Syncope and collapse
2.5
8.5
57
246
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
8.5
105
582
R60.0
ICD-10 Finland
Localized oedema
2.4
8.5
63
285
C09CA06
ATC
candesartan; oral
1.9
8.5
126
744
H02AB04
ATC
methylprednisolone; systemic
2.2
8.5
79
394
WX723
NOMESCO Finland
CPAP therapy
3.4
8.5
30
91
R03DA04
ATC
theophylline; systemic, rectal
3.4
8.5
30
91
IEY18
NOMESCO Finland
Psychiatric sleep coaching, individual
91.4
8.4
9
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
8.4
174
1139
SPAT1312
SPAT
General health counselling
1.8
8.4
174
1139
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
8.4
103
571
SPAT1307
SPAT
Psychosocial counselling and guidance
2.7
8.3
46
181
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
8.3
104
581
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.9
8.2
40
147
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
4.7
8.2
19
42
G04BD04
ATC
oxybutynin; oral, transdermal
3.0
8.2
36
125
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
4.9
8.2
18
38
F41.00
ICD-10 Finland
Moderate panic disorder
4.9
8.2
18
38
J02AC01
ATC
fluconazole; systemic
1.7
8.1
215
1506
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.5
8.1
51
214
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
8.1
300
2299
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.9
8.1
39
143
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
8.0
60
273
XG466
NOMESCO Finland
Sleep oxymetry
4.1
8.0
22
56
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
7.9
160
1037
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.1
7.9
33
111
Z00.0
ICD-10 Finland
General medical examination
1.9
7.9
107
613
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
8.6
7.9
16
19
J01FA06
ATC
roxithromycin; oral
1.7
7.8
208
1455
H53.1
ICD-10 Finland
Subjective visual disturbances
2.7
7.8
41
157
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.7
7.8
43
169
N05AF03
ATC
chlorprothixene; systemic
4.3
7.8
20
48
F43.00
ICD-10 Finland
Acute stress reaction mild
4.3
7.8
20
48
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.5
7.8
19
30
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.5
7.8
26
76
AA40B, ,
NOMESCO Finland
15.3
7.7
12
8
XKD00
NOMESCO Finland
Uroflowmetry
2.1
7.7
75
380
282
Kela drug reimbursment
Sodium oxybat
45.7
7.7
9
*
C08DB01
ATC
diltiazem; oral
3.8
7.7
23
62
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.4
7.7
52
226
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.0
7.7
33
113
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
7.7
130
799
R06AX22
ATC
ebastine; oral
2.0
7.7
99
557
C03CA01
ATC
furosemide; systemic
1.9
7.7
118
704
F32
ICD-10 Finland
Depressive episode
2.9
7.6
36
130
D07AC01
ATC
betamethasone; topical
1.7
7.6
186
1270
A03FA02
ATC
cisapride; oral, rectal
2.7
7.5
41
160
C03DA01
ATC
spironolactone; oral
2.3
7.5
61
287
N05BE01
ATC
buspirone; oral
3.6
7.5
24
68
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.2
7.5
65
315
R03AK07
ATC
formoterol and budesonide; inhalant
1.9
7.5
116
693
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
3.5
7.5
26
78
G44.2
ICD-10 Finland
Tension-type headache
2.1
7.5
81
428
Z3226
NOMESCO Finland
Physiotherapist
2.0
7.5
96
539
N07XX04
ATC
sodium oxybate; oral
81.2
7.4
8
*
J31.0
ICD-10 Finland
Chronic rhinitis
2.3
7.4
55
249
C08CA13
ATC
lercanidipine; oral
2.2
7.4
65
316
N06AB08
ATC
fluvoxamine; oral
3.8
7.4
22
59
C07AB02
ATC
metoprolol; systemic
2.0
7.4
84
451
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.1
7.4
70
351
R03AC12
ATC
salmeterol; inhalant
3.3
7.4
28
89
A99
ICPC
Disease/condition unspecnature/site
2.5
7.4
48
205
N06AA04
ATC
clomipramine; systemic
7.0
7.3
17
25
J01DB01
ATC
cefalexin; oral
1.9
7.3
440
3801
M01AE02
ATC
naproxen; oral, rectal
1.6
7.3
308
2417
L08
ICPC
Shoulder symptom/complaint
1.9
7.2
113
676
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
7.2
51
226
J01FF01
ATC
clindamycin; systemic
1.8
7.2
140
894
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
7.2
56
259
Z71.8
ICD-10 Finland
Other specified counselling
1.7
7.1
166
1115
H02AB09
ATC
hydrocortisone; systemic
4.2
7.1
19
47
SBB10
NOMESCO Finland
Dental impressions
2.5
7.1
47
202
N02BF02
ATC
pregabalin; oral
2.8
7.1
35
130
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
7.1
74
386
R05
ICD-10 Finland
Cough
1.8
7.1
113
681
E03
ICD-10 Finland
Other hypothyroidism
2.7
7.0
38
148
SFA30
NOMESCO Finland
Three-surface restoration
1.6
7.0
222
1616
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.8
7.0
124
771
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
7.0
70
359
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
7.0
58
276
K59.0
ICD-10 Finland
Constipation
2.9
7.0
32
114
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
6.0
7.0
18
31
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
7.7
6.9
15
20
J01DA01
ATC
[U] cefalexin
1.6
6.9
325
2602
M01AH01
ATC
celecoxib; oral
1.9
6.9
88
492
R01AD05
ATC
budesonide; nasal
2.4
6.9
49
218
R06AE09
ATC
levocetirizine; oral
2.0
6.9
84
463
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.2
6.9
18
44
F51.9
ICD-10 Finland
Nonorganic sleep disorder, unspecified
6.8
6.9
16
24
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
6.8
76
405
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.2
6.8
27
88
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.1
6.8
70
362
M01AH02
ATC
rofecoxib; oral
2.1
6.8
64
320
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
6.8
94
540
UJF32
NOMESCO Finland
Coloscopy
1.8
6.8
126
793
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
6.8
24
73
D01BA02
ATC
terbinafine; oral
1.7
6.7
133
853
T82
ICPC
Obesity
2.9
6.7
31
111
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.8
6.7
20
54
SPAT1360
SPAT
Extensive global examination
2.7
6.7
36
140
D07AD01
ATC
clobetasol; topical
1.9
6.7
86
483
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.8
6.6
115
710
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
6.6
62
310
M03BC51
ATC
orphenadrine, combinations; systemic
1.7
6.6
148
983
G04BD07
ATC
tolterodine; oral
3.2
6.6
26
85
WZA90
NOMESCO Finland
Other medical or dental certificate
1.7
6.5
131
842
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
6.5
30
107
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.0
6.5
28
96
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
6.5
126
802
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
6.5
43
185
E000001, ,
ATC
1.8
6.5
106
642
J45.8
ICD-10 Finland
Mixed asthma
3.8
6.4
19
51
R04.2
ICD-10 Finland
Haemoptysis
3.8
6.4
19
51
A06AD11
ATC
lactulose; oral
2.1
6.4
65
335
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
3.7
6.4
20
56
N07BB01
ATC
disulfiram; oral
3.0
6.4
27
92
J01FA10
ATC
azithromycin; systemic
1.6
6.4
314
2522
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.7
6.3
144
957
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
6.3
53
253
SPAT1229
SPAT
Assessment of need for aid
2.6
6.3
35
138
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.3
126
808
R11
ICD-10 Finland
Nausea and vomiting
2.3
6.3
48
220
D07AC13
ATC
mometasone; topical
1.7
6.3
146
976
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
6.3
250
1908
L20
ICPC
Joint symptom/complaint NOS
3.1
6.3
25
82
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.2
191
1369
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.1
6.2
57
282
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.2
71
382
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.0
6.2
71
382
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.4
6.2
22
67
SPAT1283
SPAT
Restricted health certificate
1.8
6.2
102
619
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.3
6.2
49
229
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.9
6.2
29
105
R52.2
ICD-10 Finland
Other chronic pain
3.1
6.2
25
83
E0000UV, ,
ATC
1.6
6.1
212
1564
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.1
165
1146
N03AF01
ATC
carbamazepine; oral, rectal
2.8
6.1
31
117
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.5
6.1
37
153
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.6
6.1
35
141
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
3.3
6.1
22
68
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
6.1
214
1585
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.0
77
430

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
108
5.56
27.25
1.2
1.2
410.85
447.90
mg/l
0.34
55
99
112
395
3.32
25.38
2.2
2.1
341.91
371.16
nmol/l
1.03
104
369
265
1494
2.53
24.41
2.2
1.9
100.78
95.16
pmol/l
1.04
154
788
453
3327
3.34
24.07
5.7
3.9
14.64
14.60
pmol/l
0.15
427
3034
307
1894
2.45
22.67
6.6
7.1
1.22
1.21
mmol/l
0.24
253
1628
343
2228
2.50
22.54
5.5
6.0
1.92
1.96
e9/l
0.24
310
2007
47
96
5.27
22.23
1.3
1.3
34.69
1289.58
e6/l
0.62
42
83
334
2155
2.46
22.10
5.6
6.0
0.56
0.56
e9/l
0.10
296
1897
333
2164
2.42
21.40
5.6
6.0
0.05
0.04
e9/l
0.80
296
1903
341
2243
2.43
21.27
6.0
6.2
0.20
0.19
e9/l
1.36
309
2001
45
96
5.03
20.24
1.2
1.2
2.76
14.38
e6/l
0.97
38
80
427
3161
2.73
19.90
4.6
3.9
10.96
10.50
mm/h
0.30
402
2926
207
1133
2.35
19.26
4.3
3.4
0.00
0.01
estimate
0.69
72
404
266
1624
2.27
19.02
4.2
5.1
36.13
36.14
g/l
0.01
252
1511
276
1723
2.24
18.54
6.2
6.3
1.21
1.21
mmol/l
0.28
252
1577
207
1159
2.28
18.01
2.6
2.0
130.26
255.29
u/l
1.44
191
1093
156
773
2.44
18.00
1.6
1.6
450.29
28702710.82
pmol/l
0.78
125
655
134
631
2.50
17.18
1.9
1.7
1434.24
1171.79
nmol/l
1.86
107
485
220
1283
2.21
17.15
2.5
3.4
2.35
2.35
mmol/l
0.10
201
1143
302
1998
2.17
17.03
3.5
2.7
120.29
107.82
ug/l
0.30
289
1847
492
4038
3.66
16.93
6.8
4.5
1.68
2.14
mu/l
0.91
461
3711
195
1112
2.18
15.81
3.7
4.1
7.40
7.40
ph
0.37
39
210
303
2051
2.10
15.57
5.7
6.5
—
—
—
0
0
261
1677
2.08
15.37
2.5
2.2
76.76
75.66
nmol/l
0.26
246
1511
74
273
2.98
15.17
4.3
3.7
4.27
4.67
pmol/l
2.83
59
248
345
2492
2.08
14.38
8.6
9.4
3.96
4.05
e9/l
0.42
314
2197
174
981
2.15
14.27
2.6
2.0
3.14
2.98
mg/l
0.25
161
843
418
3267
2.27
13.93
7.1
7.5
75.74
77.39
u/l
0.37
398
3058
214
1315
2.04
13.87
2.5
2.6
53.78
57.76
u/l
1.06
201
1219
381
2887
2.11
13.54
4.5
3.5
—
—
—
0
0
230
1478
1.97
12.91
4.0
3.3
366.30
33.62
ng/l
0.52
147
959
111
549
2.29
12.40
2.1
2.3
2.44
2.38
g/l
0.55
101
508
124
645
2.20
12.25
2.6
2.7
2.44
2.44
mmol/l
0.01
114
566
295
2089
1.92
12.15
4.2
3.3
0.00
0.00
estimate
0.50
82
435
116
589
2.24
12.15
1.5
1.4
795.86
484.13
titre
0.63
29
126
295
2090
1.92
12.13
5.2
4.5
0.00
0.00
estimate
-0.00
80
416
361
2738
1.98
12.05
5.0
3.9
48.25
1006.16
e6/l
—
8
43
75
317
2.59
11.80
4.1
3.0
—
—
—
0
0
295
2112
1.88
11.52
4.2
3.3
0.00
0.02
estimate
0.80
75
393
148
846
2.04
11.33
1.5
1.5
20.02
20.90
nmol/l
0.28
135
726
292
2091
1.87
11.32
5.8
6.1
28.70
28.54
%
0.09
273
1973
116
606
2.17
11.26
2.1
2.3
13.73
13.64
umol/l
0.04
105
562
166
994
1.97
11.11
3.7
3.2
1000.04
954.12
ng/l
0.06
139
844
173
1053
1.95
11.02
1.4
1.3
1.39
2.04
u/ml
0.39
53
290
33
89
3.89
11.02
1.2
1.3
—
—
—
0
0
507
4465
3.50
10.95
19.6
13.7
139.62
139.66
mmol/l
0.16
495
4338
284
2031
1.85
10.91
5.9
6.4
8.37
8.40
%
0.05
264
1911
488
4215
2.76
10.86
5.3
4.1
5.98
5.87
mmol/l
0.96
451
3877
507
4477
3.45
10.65
19.6
13.8
3.97
3.95
mmol/l
0.68
494
4339
98
490
2.22
10.56
4.2
5.9
1.03
1.02
mmol/l
0.10
91
453
69
299
2.50
10.28
2.6
2.3
4.03
8.04
ug/l
2.34
55
267
321
2413
1.82
10.20
5.4
4.9
6.47
6.61
mmol/l
0.61
302
2216
193
1246
1.86
10.11
3.8
3.1
8.19
8.00
mmol/l
0.18
164
1051
280
2024
1.80
10.11
5.8
6.0
2.98
2.80
%
0.66
262
1896
273
1960
1.80
10.07
10.0
8.9
0.00
0.00
e9/l
0.19
228
1614
141
823
1.97
10.02
2.5
2.4
6.83
6.51
e6/l
0.07
126
727
132
753
2.00
10.02
1.3
1.3
18.34
33.07
iu/ml
2.11
41
242
155
936
1.92
9.96
1.8
1.8
0.95
1.08
mg/l
0.28
111
697
100
516
2.15
9.93
2.2
2.3
23.60
23.53
%
0.02
86
441
46
165
2.96
9.86
1.4
1.3
0.96
2.23
u/ml
—
5
13
39
128
3.21
9.72
5.3
4.1
—
—
—
0
0
284
2079
1.78
9.66
5.8
5.9
56.74
56.97
%
0.13
264
1964
270
1953
1.77
9.53
5.8
6.1
0.63
0.68
%
0.89
251
1826
248
1758
1.76
9.33
14.1
11.3
1.19
1.18
inr
0.06
75
547
240
1690
1.76
9.20
4.0
3.1
5.88
5.83
ph
0.08
17
148
150
920
1.88
9.08
4.7
3.4
1.01
1.02
kg/l
0.65
16
129
59
253
2.50
8.97
3.1
3.2
7.40
7.40
ph
—
5
28
458
3933
2.13
8.86
6.8
5.2
39.16
39.36
mmol/mol
0.18
422
3682
499
4443
2.78
8.85
17.2
12.3
18.40
22.46
mg/l
2.41
407
3408
166
1062
1.82
8.73
2.3
2.8
6116.14
7283.49
umol/l
0.10
141
938
369
2964
1.79
8.67
4.6
3.9
—
—
—
0
0
124
726
1.92
8.60
1.5
1.3
5.66
10.58
u/ml
0.58
55
294
61
276
2.37
8.25
1.4
1.3
—
43.55
—
0
21
88
464
2.07
8.19
1.8
1.6
—
—
—
0
0
60
271
2.37
8.15
2.6
3.6
71.47
73.28
ng/l
0.08
52
245
286
2164
1.69
8.10
5.3
6.6
9.83
11.19
umol/l
2.29
272
2055
131
800
1.84
7.92
2.7
2.6
543.27
555.91
mosm/kgh2o
0.25
109
681
19
30
6.52
7.77
1.6
1.5
—
—
—
0
0
165
1085
1.75
7.76
3.1
2.7
0.35
0.47
e6/l
0.51
135
819
30
98
3.18
7.55
3.4
1.9
—
—
—
0
0
515
4726
3.29
7.38
11.9
9.8
35.37
26.91
u/l
0.73
497
4568
160
1058
1.73
7.32
2.9
2.7
—
—
—
0
0
166
1112
1.71
7.23
3.5
3.3
435.40
228.51
mg/l
0.22
112
721
60
287
2.23
7.13
1.3
1.2
198.31
254.41
u/ml
0.22
55
261
44
184
2.52
7.06
3.1
3.5
—
—
—
0
0
19
35
5.59
6.97
1.2
1.2
—
—
—
0
0
105
621
1.86
6.95
2.6
3.7
0.83
0.82
mmol/l
0.24
97
590
167
1131
1.69
6.94
4.1
3.5
—
—
—
0
0
205
1468
1.64
6.86
3.0
3.5
56.78
30.81
u/l
0.43
196
1407
173
1186
1.68
6.86
3.2
2.9
42.89
108.05
e6/l
0.59
140
910
45
195
2.43
6.70
1.3
1.5
471.13
295.72
mu/l
0.65
39
178
511
4701
2.87
6.68
15.8
11.6
—
—
—
0
0
374
3118
1.66
6.62
3.7
3.1
43.46
45.29
u/l
0.21
353
2955
95
555
1.87
6.52
2.0
2.3
108.59
128.41
ug/g
0.35
74
432
39
160
2.55
6.51
3.2
1.6
—
—
—
0
0
65
339
2.04
6.20
2.2
2.6
10.78
10.42
g/l
0.30
57
306
27
94
2.97
6.14
4.9
3.1
7.41
7.42
ph
0.94
19
77
92
542
1.84
6.13
1.2
1.2
—
—
—
0
0
169
1182
1.63
6.07
4.4
3.9
9.51
9.16
mg/mmol
0.04
111
755
34
137
2.58
5.90
3.5
2.0
—
—
—
0
0
194
1419
1.58
5.72
4.1
3.3
41.16
99.73
e6/l
1.23
151
982
48
231
2.18
5.63
1.9
2.7
—
—
—
0
0
55
280
2.07
5.60
1.5
1.4
—
—
—
0
0
23
77
3.08
5.59
4.0
2.9
—
—
—
0
0
39
174
2.34
5.47
1.1
1.1
—
—
—
0
0
42
195
2.25
5.38
3.0
1.6
—
—
—
0
0
56
293
2.02
5.30
2.9
4.1
1.23
1.23
mmol/l
0.01
48
259
44
210
2.19
5.28
3.0
1.6
—
—
—
0
0
86
524
1.76
5.10
1.5
1.5
—
—
—
0
0
44
213
2.16
5.10
3.0
1.6
—
—
—
0
0
17
50
3.48
5.06
1.1
1.4
71.33
69.12
mmol/l
0.06
12
41
63
351
1.90
4.98
1.2
1.2
116.98
175.66
iu/ml
0.60
21
146
43
209
2.15
4.94
3.1
1.6
—
—
—
0
0
43
209
2.15
4.94
3.0
1.6
—
—
—
0
0
46
231
2.08
4.87
11.8
11.0
94.52
94.49
%
0.02
46
231
134
930
1.59
4.83
5.2
3.2
—
—
—
0
0
13
25
5.30
4.79
1.1
1.0
298.33
258.73
ng/l
—
6
15
13
25
5.30
4.79
1.1
1.0
1036.00
637.33
ng/l
—
6
15
65
376
1.83
4.58
3.2
3.3
—
—
—
0
0
15
44
3.48
4.49
1.3
1.4
—
—
—
0
0
20
72
2.85
4.33
1.3
1.7
—
—
—
0
0
27
114
2.44
4.30
1.5
1.5
301.60
297.19
ug/g
0.03
15
66
254
2056
1.45
4.27
2.4
2.6
—
—
—
0
0
43
223
2.01
4.19
3.9
6.5
—
—
—
0
0
131
933
1.53
4.16
1.5
1.5
2.33
2.42
g/l
0.17
84
591
163
1219
1.48
4.09
3.1
2.9
—
—
—
0
0
8
10
8.10
4.07
1.5
1.0
—
—
—
0
0
90
592
1.63
4.01
2.0
2.2
—
—
—
0
0
46
249
1.93
3.98
2.2
2.8
114.33
165.35
ng/l
0.73
40
222
32
153
2.16
3.87
1.5
1.6
—
—
—
0
0
19
71
2.74
3.86
6.0
3.2
2.50
2.15
mmol/l
0.16
13
44
142
1044
1.49
3.85
8.0
7.0
—
—
—
0
0
457
4189
1.62
3.81
4.6
3.7
1.41
1.28
mmol/l
2.85
421
3893
26
115
2.33
3.77
1.7
1.3
5.45
11.10
u/ml
—
6
21
44
240
1.91
3.74
3.0
2.3
812.84
3225.02
u/l
0.94
13
104
10
20
5.07
3.70
2.9
2.0
—
—
—
0
0
49
278
1.84
3.69
3.0
2.9
4.27
4.52
kpa
0.49
49
271
14
45
3.17
3.67
1.4
1.5
—
—
—
0
0
471
4360
1.66
3.65
5.1
4.1
4.58
4.70
mmol/l
1.65
432
4084
35
178
2.03
3.62
2.6
2.4
1.27
1.27
%
0.01
35
178
67
420
1.68
3.59
9.0
9.5
1.67
1.24
mmol/l
0.47
55
338
138
1022
1.47
3.58
3.5
3.8
94.32
92.61
%
0.32
133
998
10
21
4.83
3.57
3.4
2.4
36390.00
39833.57
ug/l
—
10
21
475
4413
1.67
3.54
5.6
4.5
2.73
2.81
mmol/l
1.25
434
4108
6
6
10.09
3.50
1.2
1.0
—
—
—
0
0
468
4335
1.63
3.49
5.0
4.1
1.40
1.46
mmol/l
2.29
427
4041
41
224
1.90
3.48
6.4
8.8
25.75
24.78
mmol/l
0.99
41
212
58
354
1.72
3.43
9.7
10.6
126.93
121.27
g/l
1.17
58
347
432
3943
1.49
3.33
18.1
14.9
14.67
14.68
%
0.02
427
3881
11
28
3.99
3.30
1.7
1.3
890.50
1902.59
e6/l
—
6
17
523
5026
2.67
3.29
26.8
18.2
258.83
252.46
e9/l
1.46
512
4907
132
986
1.45
3.25
4.7
4.2
—
—
—
0
0
14
49
2.91
3.21
1.4
1.3
—
—
nmol/l
—
0
0
523
5030
2.64
3.21
26.5
18.0
30.23
30.23
pg
0.01
514
4966
523
5030
2.64
3.21
26.5
18.1
90.59
90.54
fl
0.10
514
4967
10
24
4.23
3.21
2.0
1.3
—
—
—
0
0
8
15
5.40
3.20
1.9
7.1
—
—
—
0
0
211
1716
1.38
3.19
1.9
2.0
—
—
—
0
0
523
5031
2.63
3.19
26.7
18.1
4.55
4.54
e12/l
0.13
511
4903
523
5031
2.63
3.19
26.7
18.2
6.74
6.69
e9/l
0.24
510
4898
33
173
1.97
3.17
2.6
2.3
0.75
0.66
%
0.59
33
173
17
67
2.59
3.15
2.8
2.2
—
—
—
0
0
523
5034
2.61
3.12
26.8
18.2
136.90
136.57
g/l
0.21
514
4969
53
326
1.69
3.07
3.2
3.6
6.17
5.81
kpa
1.76
53
319
7
12
5.89
3.03
1.0
1.3
—
—
—
0
0
49
296
1.72
3.03
10.7
10.0
—
—
—
0
0
522
5027
2.47
2.99
27.1
18.2
40.54
40.54
%
0.01
501
4739
149
1154
1.40
2.98
3.4
2.6
—
—
—
0
0
52
323
1.68
2.91
3.2
3.6
3.24
1.98
mmol/l
1.73
46
269
62
404
1.60
2.88
1.6
2.6
1.70
1.81
%
0.52
56
363
28
145
1.98
2.80
2.4
1.7
42.11
38.94
nmol/l
0.23
28
140
16
66
2.47
2.73
3.3
2.5
17.98
16.43
%
0.79
11
35
21
99
2.17
2.68
1.0
1.1
—
—
—
0
0
45
276
1.69
2.65
1.1
1.2
—
—
—
0
0
8
20
4.04
2.57
1.3
1.5
132.00
159.12
nmol/l
—
8
20
54
351
1.60
2.55
1.3
1.2
—
—
—
0
0
52
335
1.61
2.55
3.9
5.2
0.08
0.13
%
0.26
13
109
14
56
2.54
2.55
1.3
1.3
—
—
—
0
0
51
328
1.61
2.52
3.6
4.8
0.38
0.52
%
0.20
13
112
10
32
3.16
2.44
5.1
2.9
31.26
19.48
mu/l
—
10
32
57
380
1.56
2.43
4.0
4.0
—
—
—
0
0
17
77
2.25
2.40
2.3
3.4
3.33
4.47
e9/l
1.59
17
77
21
104
2.06
2.39
2.4
1.3
—
—
—
0
0
14
58
2.45
2.38
2.9
1.3
—
—
—
0
0
5
8
6.30
2.37
1.0
1.0
7.53
6.30
mg/g
—
5
8
63
436
1.50
2.28
1.6
1.4
—
—
—
0
0
68
480
1.48
2.24
1.2
1.3
—
—
—
0
0
49
322
1.57
2.23
3.6
5.2
0.00
0.20
%
—
9
97
9
29
3.14
2.23
1.0
1.7
13.90
11.83
umol/l
—
9
29
54
363
1.54
2.23
3.9
5.0
0.53
0.92
%
0.60
15
137
17
80
2.16
2.21
2.4
3.9
54.65
56.19
%
0.18
17
80
23
122
1.92
2.19
1.3
1.2
—
—
—
0
0
9
30
3.03
2.15
1.8
1.5
—
—
—
0
0
14
63
2.26
2.02
1.1
1.1
—
—
—
0
0
11
44
2.53
2.02
4.3
2.7
2.87
1.87
g/24h
—
6
26
38
241
1.62
2.02
1.3
1.2
—
—
—
0
0
45
298
1.56
2.00
1.6
2.8
3.42
6.02
e9/l
1.21
37
253
25
141
1.81
2.00
2.5
3.1
0.16
0.36
g/l
1.22
11
56
15
73
2.09
1.82
1.2
1.1
0.28
0.82
u/ml
—
6
29
16
80
2.03
1.81
1.3
1.3
—
—
—
0
0
41
273
1.54
1.80
1.4
1.6
1.05
1.38
g/l
1.32
36
252
20
109
1.87
1.79
1.8
3.1
—
—
—
0
0
37
242
1.57
1.76
1.6
1.4
19.47
27.29
iu/l
0.87
32
207
23
133
1.76
1.72
1.2
1.2
—
—
—
0
0
72
541
1.38
1.72
1.6
1.8
—
—
—
0
0
89
692
1.34
1.71
4.1
3.4
160.37
376.50
ng/l
0.90
66
499
11
48
2.32
1.71
1.9
1.6
297.09
405.69
pmol/l
0.65
11
42
42
285
1.51
1.70
1.8
2.5
72.38
74.38
e9/l
0.16
33
214
40
269
1.53
1.69
1.9
1.7
—
—
—
0
0
8
31
2.60
1.66
1.6
1.9
—
—
—
0
0
25
150
1.70
1.66
1.4
2.0
1.94
1.40
g/l
1.52
20
128
51
365
1.44
1.60
1.6
2.6
0.22
0.22
g/l
0.07
46
343
6
20
3.02
1.58
2.5
2.4
7.83
9.38
mmol/l
—
6
20
15
78
1.95
1.55
1.2
1.1
4.37
5.30
u/ml
—
8
34
14
71
2.00
1.55
2.4
2.8
—
—
—
0
0
125
1035
1.27
1.52
2.0
1.9
—
—
—
0
0
6
21
2.88
1.51
2.0
5.5
—
—
—
0
0
15
80
1.90
1.46
1.2
1.1
—
—
—
0
0
15
80
1.90
1.46
1.2
1.1
—
—
—
0
0
11
52
2.14
1.45
1.5
1.2
—
—
—
0
0
7
29
2.43
1.39
1.3
1.2
—
—
—
0
0
17
97
1.78
1.36
1.2
1.2
213.15
260.34
u/ml
0.42
12
61
5
17
2.96
1.36
1.2
1.1
139.60
175.22
mmol/24h
—
5
17
10
47
2.15
1.34
1.9
2.9
—
—
—
0
0
26
168
1.58
1.34
1.3
1.2
—
—
—
0
0
9
43
2.11
1.31
1.2
1.1
—
—
—
0
0
6
24
2.52
1.30
1.0
1.2
113.67
206.66
iu/ml
—
6
24
50
373
1.38
1.28
2.3
2.4
28.60
31.83
u/l
0.47
45
323
11
55
2.02
1.28
1.5
3.1
—
—
—
0
0
73
581
1.30
1.22
1.7
1.6
—
—
—
0
0
158
1379
1.21
1.18
1.5
1.5
—
—
—
0
0
8
40
2.01
1.12
1.1
1.1
—
—
—
0
0
10
51
1.98
1.12
1.2
1.5
—
—
—
0
0
74
603
1.26
1.05
3.4
2.7
3.01
2.30
e6/l
0.21
39
334
153
1345
1.19
1.05
2.1
2.3
—
—
—
0
0
5
22
2.28
1.03
1.2
1.2
—
—
—
0
0
7
35
2.01
1.00
3.1
2.0
17.21
17.63
ug/l
—
7
35
151
1332
1.19
0.99
4.7
4.5
1.92
2.28
ug/l
0.49
135
1194
9
49
1.85
0.99
1.2
1.1
—
—
—
0
0
5
23
2.18
0.98
1.4
1.2
—
—
—
0
0
0
32
0.00
0.95
0.0
1.6
—
—
—
0
0
7
37
1.90
0.94
2.4
3.2
—
—
—
0
0
12
71
1.71
0.89
1.2
1.8
—
—
—
0
0
8
42
1.92
0.89
14.1
15.8
1018.38
1539.90
nmol/l
—
8
42
8
42
1.92
0.89
11.9
11.6
664.12
846.05
nmol/l
—
8
42
6
30
2.01
0.87
1.7
2.0
46.93
36.48
%
—
6
30
6
30
2.01
0.87
1.2
1.3
6.18
6.72
ug/l
—
6
25
8
44
1.83
0.86
1.3
1.3
—
—
—
0
0
17
113
1.52
0.83
1.1
1.1
—
—
—
0
0
12
73
1.66
0.82
1.8
2.7
—
—
—
0
0
18
123
1.48
0.78
1.7
2.0
1.65
6.76
iu/l
—
7
47
6
34
1.77
0.76
1.7
1.4
1.10
1.30
promille
—
6
28
73
618
1.21
0.76
1.8
1.7
—
—
—
0
0
12
75
1.61
0.75
1.0
1.1
1.20
29.79
iu/ml
—
5
19
14
92
1.54
0.73
1.2
1.1
1.71
2.78
u/ml
—
7
48
114
1011
1.16
0.71
2.1
2.3
—
—
—
0
0
25
187
1.35
0.69
1.6
1.7
—
—
—
0
0
10
61
1.65
0.69
2.0
1.5
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
10
154
0.64
0.65
1.2
1.5
—
—
—
0
0
5
29
1.73
0.64
1.0
1.0
—
0.54
—
0
7
25
190
1.33
0.64
2.6
2.3
—
—
—
0
0
26
199
1.32
0.63
1.2
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
13
89
1.47
0.58
1.2
1.4
97.25
106.29
u/ml
—
8
14
18
132
1.38
0.57
1.4
2.6
—
—
—
0
0
10
149
0.66
0.57
1.2
1.4
—
—
—
0
0
13
90
1.46
0.56
2.7
4.6
—
—
—
0
0
10
148
0.67
0.56
1.2
1.4
—
—
—
0
0
6
38
1.59
0.54
1.0
1.2
551.00
395.61
nmol/l
—
6
33
11
74
1.50
0.53
1.3
1.1
0.40
1.76
u/ml
—
6
35
125
1140
1.13
0.53
1.6
1.7
1.49
1.37
mmol/l
0.73
99
970
10
66
1.52
0.53
1.8
1.9
13.00
13.02
%
—
10
66
63
548
1.17
0.52
1.5
1.4
—
—
—
0
0
6
40
1.51
0.51
1.2
2.1
—
—
—
0
0
32
386
0.82
0.48
3.6
4.4
5.67
37.03
ug/l
0.83
22
309
87
783
1.13
0.46
2.9
2.8
0.82
0.73
ug/l
0.20
56
499
95
862
1.12
0.45
1.6
1.7
—
—
—
0
0
10
69
1.46
0.44
1.1
1.2
—
—
—
0
0
47
542
0.85
0.44
1.3
1.3
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
6.45
—
0
15
0
16
0.00
0.41
0.0
3.1
—
—
—
0
0
17
133
1.29
0.39
4.6
10.5
—
—
—
0
0
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
8
112
0.71
0.37
2.5
4.6
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
9
70
1.29
0.37
1.3
1.1
—
—
—
0
0
9
70
1.29
0.37
1.0
1.2
11.11
35.09
u/l
—
9
62
28
331
0.84
0.36
1.5
1.4
—
—
—
0
0
19
154
1.24
0.34
2.2
8.2
1.82
1.67
%
0.14
19
146
17
210
0.80
0.34
3.4
3.4
—
—
—
0
0
7
96
0.73
0.31
1.1
1.2
—
—
—
0
0
30
262
1.15
0.27
2.9
2.3
—
—
—
0
0
10
77
1.30
0.26
1.1
1.3
—
—
—
0
0
41
368
1.12
0.26
1.6
1.4
—
—
—
0
0
58
532
1.10
0.25
1.2
1.2
—
—
—
0
0
38
341
1.12
0.24
1.2
1.4
—
—
—
0
0
9
77
1.17
0.24
1.3
1.1
—
—
—
0
0
18
152
1.19
0.24
2.2
8.4
0.77
0.89
%
0.85
18
144
19
162
1.18
0.23
1.3
1.2
—
—
—
0
0
15
125
1.21
0.22
1.0
1.2
—
—
—
0
0
53
488
1.10
0.22
1.7
3.3
5.28
8.92
umol/l
2.60
40
431
5
41
1.22
0.22
1.6
3.0
—
—
—
0
0
5
42
1.19
0.21
6.2
3.3
54.40
54.41
%
—
5
37
5
42
1.19
0.21
2.8
2.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
8.3
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
54.68
—
0
11
0
11
0.00
0.21
0.0
9.0
—
25.57
—
0
11
12
98
1.23
0.21
1.2
1.5
—
—
—
0
0
8
102
0.78
0.21
1.5
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.66
—
0
9
23
208
1.11
0.14
15.3
13.5
—
—
—
0
0
20
181
1.11
0.12
1.5
1.3
163.00
231.45
miu/ml
—
7
93
7
66
1.06
0.08
1.3
1.2
—
—
—
0
0
7
68
1.03
0.08
1.4
1.8
—
—
—
0
0
10
104
0.96
0.00
1.9
2.3
—
—
—
0
0
12
117
1.03
0.00
2.3
10.2
1.25
1.27
mmol/l
0.02
12
103
8
82
0.98
-0.00
2.3
12.3
11.50
11.29
mmol/l
—
8
76
0
9
0.00
-0.00
0.0
9.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
1.78
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
32.71
—
0
7
6
68
0.88
-0.00
1.8
3.1
16.67
21.91
u/ml
—
6
68
6
62
0.97
-0.00
2.7
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.3
—
—
—
0
0
8
86
0.93
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
190.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
5.5
3.3
0.17
0.67
%
—
6
59
0
7
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
0.96
—
0
5
5
52
0.96
-0.00
2.6
2.6
4.00
4.05
mmol/l
—
5
52
5
52
0.96
-0.00
2.6
2.6
—
—
—
0
0
173
1730
1.00
-0.00
3.0
2.6
—
—
—
0
0
8
82
0.98
-0.00
2.3
12.3
104.25
105.61
mmol/l
—
8
76
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
2.0
—
—
—
0
0
5
52
0.96
-0.00
2.6
2.6
109.00
105.54
mmol/l
—
5
52
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_HYPERSOMNIA and mortality.

Females

Parameter HR [95% CI] p-value
F5_HYPERSOMNIA 1.495 [1.17, 1.91] 0.001
Birth year 0.995 [0.99, 1.0] 0.241

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1255 females with F5_HYPERSOMNIA died.

Males

Parameter HR [95% CI] p-value
F5_HYPERSOMNIA 1.255 [1.08, 1.45] 0.003
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 1339 males with F5_HYPERSOMNIA died.

Mortality risk

Mortality risk for people of age

years, who have F5_HYPERSOMNIA.

N-year risk Females Males
1 0.177% 0.207%
5 0.948% 1.378%
10 2.469% 3.501%
15 4.569% 6.807%
20 7.849% 11.469%

Relationships between endpoints

↥

Index endpoint: F5_HYPERSOMNIA – Hypersomnia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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