Normal-pressure hydrocephalus

G6_HCNP

normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G91.2
  • Cause of death: ICD-10 G91.2

2 out of 7 registries used, show all original rules.

1829

4. Check minimum number of events

None

1829

5. Include endpoints

None

1829

6. Filter based on genotype QC (FinnGen only)

1783

Control definitions (FinnGen only)

Control exclude
G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia normotensiva

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8138 4029 4003
Only index persons 6703 3428 3275
Unadjusted period prevalence (%)
Whole population 0.11 0.12 0.11
Only index persons 0.13 0.13 0.13
Median age at first event (years)
Whole population 74.05 74.92 73.17
Only index persons 73.83 74.66 72.95

-FinnGen-

Key figures

All Female Male
Number of individuals 1783 839 944
Unadjusted period prevalence (%) 0.37 0.30 0.43
Median age at first event (years) 73.36 73.52 73.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1829
Matched controls
18290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AA1AA
NOMESCO Finland
Head X-ray examination
71.6
307.7
290
48
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
307.7
1829
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
7798.5
307.7
1066
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
22.2
307.7
661
455
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
3689.0
307.7
319
*
AA1AD
NOMESCO Finland
CT of head and brain
6.7
307.7
1250
4481
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
17.7
307.7
313
211
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
277.3
259
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
2824.2
271.7
256
*
AAF00
NOMESCO Finland
Ventriculostomy
83.5
261.9
139
18
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
228.0
214
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
2098.6
209.4
199
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.7
171.4
370
781
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
874.3
165.4
160
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.2
144.1
339
766
P20
ICPC
Memory disturbance
3.6
143.0
702
2715
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
141.5
134
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
127.6
121
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
6.1
120.5
226
413
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
1191.2
116.0
112
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
401.9
114.8
114
*
SPAT1053
SPAT
Memory test
2.9
94.4
643
2892
L28
ICPC
Limited function/disability (L)
2.8
91.8
662
3061
R42
ICD-10 Finland
Dizziness and giddiness
2.8
91.6
716
3450
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
4.7
84.4
211
493
SPAT1216
SPAT
Assessment of functional ability
2.8
84.3
596
2707
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.2
82.7
239
625
F03
ICD-10 Finland
Unspecified dementia
4.0
81.5
257
716
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
81.1
380
1372
SPAT1229
SPAT
Assessment of need for aid
3.4
80.6
340
1151
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
12.9
79.9
78
63
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.1
79.0
393
1468
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.0
78.8
249
694
N99
ICPC
Neurological disease other
9.5
76.5
92
101
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
198.1
73.7
76
*
R53
ICD-10 Finland
Malaise and fatigue
2.5
71.4
649
3289
N05AX08
ATC
risperidone; systemic
3.2
68.4
319
1140
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
66.8
648
3363
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.2
66.2
306
1087
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
60.4
315
1195
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
59.5
515
2517
A28
ICPC
Limited function/disability NOS
2.3
59.2
622
3310
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
59.1
367
1528
N03AG01
ATC
valproic acid; systemic, rectal
4.1
58.9
172
450
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.4
57.8
230
743
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
56.2
496
2437
N06DA02
ATC
donepezil; oral
2.9
55.5
304
1181
G30.1
ICD-10 Finland
Alzheimer disease with late onset
2.8
55.0
318
1272
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
54.4
52
*
U04
ICPC
Incontinence urine
3.2
53.8
232
786
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
53.7
824
5064
N28
ICPC
Limited function/disability (N)
6.3
53.3
92
153
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.4
53.1
214
695
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.8
53.0
318
1295
N05AH04
ATC
quetiapine; oral
2.6
51.7
365
1610
TAB00
NOMESCO Finland
Lumbar puncture
4.6
51.4
129
300
SPAT1234
SPAT
Support of social functional capacity
3.2
51.3
225
769
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
6.2
50.8
88
147
G04BD08
ATC
solifenacin; oral
3.0
48.7
243
894
S06.0
ICD-10 Finland
Concussion
2.7
47.9
291
1189
N06DX01
ATC
memantine; oral
2.5
47.1
352
1590
N29
ICPC
Neurological sympt/complt other
6.0
47.0
85
148
G04BD12
ATC
mirabegron; oral
2.4
46.6
373
1738
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
7.7
46.4
66
89
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
46.0
44
*
G20
ICD-10 Finland
Parkinson disease
3.7
43.6
143
405
N06AB10
ATC
escitalopram; oral
2.4
43.3
336
1540
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.0
42.1
204
736
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.7
41.7
137
388
F06.7
ICD-10 Finland
Mild cognitive disorder
3.7
41.5
139
399
G04BD07
ATC
tolterodine; oral
3.1
41.3
192
676
N06DA03
ATC
rivastigmine; oral, transdermal
2.9
40.5
210
786
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
40.1
671
4144
N05AH03
ATC
olanzapine; systemic
3.6
38.1
130
378
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.3
38.0
156
510
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
3.1
37.6
169
583
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
8.1
37.2
50
63
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
36.3
397
2089
N06AB04
ATC
citalopram; systemic
2.1
36.2
439
2402
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
7.5
36.1
52
71
SPAT1254
SPAT
Administration of medicine
2.1
35.5
423
2298
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
5.3
35.4
72
140
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
33.8
418
2296
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
2.8
33.6
175
655
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
33.4
32
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
13.1
32.3
31
24
M48.0
ICD-10 Finland
Spinal stenosis
2.1
32.3
364
1929
A04
ICPC
Weakness/tiredness general
2.1
31.8
372
1997
P70
ICPC
Dementia
3.3
31.6
124
394
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
31.3
30
*
N18
ICPC
Paralysis/weakness
4.2
30.7
83
204
XA800
NOMESCO Finland
Neuropsychological investigation
4.0
30.5
88
227
SPAT1101
SPAT
Orthostatic test
2.7
30.4
171
666
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
29.4
138
487
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
29.3
194
818
R51.80
ICD-10 Finland
Headache
2.2
29.2
268
1306
R41.0
ICD-10 Finland
Disorientation, unspecified
3.1
29.2
126
424
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.7
29.1
68
149
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
7.0
28.9
44
64
SPAT1231
SPAT
Assessment of adjustments needed in living environment
3.9
28.7
87
233
N02BE01
ATC
paracetamol; systemic, rectal
2.4
28.1
1646
14456
N05AX12
ATC
aripiprazole; systemic
5.8
27.8
51
90
R32
ICD-10 Finland
Unspecified urinary incontinence
3.5
27.7
100
301
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
7.5
27.2
39
53
SPAT1301
SPAT
No procedures
1.7
27.2
693
4744
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
27.1
26
*
K90
ICPC
Stroke/cerebrovascular accident
3.2
27.0
112
368
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.0
26.5
323
1750
R1250
NOMESCO Finland
Evaluation of functional capability
4.2
26.3
70
170
SPAT1252
SPAT
Overall medication plan or its review
2.3
26.3
211
970
W19
ICD-10 Finland
Unspecified fall
2.2
26.1
249
1229
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
9.5
25.3
30
32
N06AX11
ATC
mirtazapine; oral
1.7
24.8
635
4325
N30.0
ICD-10 Finland
Acute cystitis
1.9
24.5
361
2085
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
8.3
24.4
32
39
WYA20
NOMESCO Finland
Home visit
3.6
24.2
80
227
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
23.8
212
1016
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.9
23.8
119
435
Z03
ICPC
Housing/neighbourhood problem
6.9
23.4
36
53
SPAT1042
SPAT
Guidance concerning balance maintenance
7.7
23.0
32
42
N06AX16
ATC
venlafaxine; oral
2.2
22.9
206
992
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
3.0
22.5
103
358
N04AA02
ATC
biperiden; systemic
4.9
21.3
47
98
R55
ICD-10 Finland
Syncope and collapse
1.9
21.3
296
1669
N05AB03
ATC
perphenazine; systemic, rectal
3.5
21.2
75
223
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.2
21.2
86
279
G30.8
ICD-10 Finland
Other Alzheimer disease
2.8
20.7
108
403
N06AB06
ATC
sertraline; oral
2.3
20.5
171
797
N87
ICPC
Parkinsonism
3.9
20.4
61
162
SPAT1251
SPAT
Organisation of medication
2.6
20.1
116
456
N06AX26
ATC
vortioxetine; oral
2.8
19.7
103
385
G04BD04
ATC
oxybutynin; oral, transdermal
2.2
19.6
166
778
J01CA08
ATC
pivmecillinam; oral
1.6
19.6
694
5064
N05BA04
ATC
oxazepam; oral
1.7
19.5
502
3383
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
19.5
349
2128
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.8
19.3
59
159
R27.0
ICD-10 Finland
Ataxia, unspecified
8.0
19.2
26
33
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
19.2
693
5073
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
2.7
19.1
103
391
A06AD11
ATC
lactulose; oral
1.7
19.1
404
2580
G04BD09
ATC
trospium; oral
3.0
19.0
85
292
N03AX14
ATC
levetiracetam; systemic
3.3
19.0
72
224
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
18.9
109
429
L99
ICPC
Musculoskeletal disease other
3.7
18.8
59
162
N03AX09
ATC
lamotrigine; oral
3.5
18.8
64
186
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
18.5
52
132
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.9
18.5
88
313
G04CA02
ATC
tamsulosin; oral
1.6
18.4
600
4276
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
7.9
18.3
25
32
SPAT1304
SPAT
Counselling and guidance related to ageing
1.9
18.1
239
1321
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.0
17.6
219
1186
Z75.5
ICD-10 Finland
Holiday relief care
4.4
17.6
44
102
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
5.9
17.5
31
53
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.8
17.4
303
1827
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
4.1
17.4
47
116
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.2
17.3
70
227
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.7
17.2
55
153
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
17.1
302
4694
A29
ICPC
General symptom/complaint other
1.8
16.8
287
1718
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
3.5
16.8
57
165
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.3
16.8
62
190
Z00.0
ICD-10 Finland
General medical examination
1.7
16.8
370
2383
Z2445
NOMESCO Finland
Psychologist
3.7
16.5
53
148
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
2.0
16.4
204
1105
ZXD05
NOMESCO Finland
Urgent procedure
1.6
16.3
558
3999
F22.0
ICD-10 Finland
Delusional disorder
4.5
16.2
39
88
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
16.0
282
1704
N05AN01
ATC
lithium; oral
4.4
16.0
40
93
AXX01, ,
SPAT
2.6
15.9
95
380
WX320
NOMESCO Finland
Spinalanesthesy
0.5
15.9
205
3491
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
15.7
613
4516
SPAT1167
SPAT
Insertion of urinary catheter
2.4
15.6
107
457
R5110, ,
SPAT
2.0
15.5
165
844
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
161.3
15.5
16
*
SPAT1307
SPAT
Psychosocial counselling and guidance
3.1
15.3
63
206
N05AH02
ATC
clozapine; systemic
6.7
15.3
24
36
J01EA01
ATC
trimethoprim; systemic
1.6
15.3
522
3729
N17
ICPC
Vertigo/dizziness
1.8
15.1
278
1698
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
3.7
15.1
48
133
F05.9
ICD-10 Finland
Delirium, unspecified
2.8
14.9
73
264
R26
ICD-10 Finland
Abnormalities of gait and mobility
12.5
14.9
26
21
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
14.9
372
2467
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.4
14.8
52
154
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
2.2
14.8
130
618
SPAT1246
SPAT
Screening of depression or other psychiatric problem
3.3
14.7
56
175
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.8
14.7
234
1370
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
14.7
158
812
N30.9
ICD-10 Finland
Cystitis, unspecified
2.1
14.5
143
711
N03AB02
ATC
phenytoin; systemic
4.0
14.2
40
102
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.0
14.1
30
61
T90.5
ICD-10 Finland
Sequelae of intracranial injury
5.1
13.9
29
58
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.2
13.7
116
544
L29
ICPC
Musculoskeletal sympt/complt other
1.9
13.6
168
905
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
1.9
13.6
180
993
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.6
13.6
32
71
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
13.5
586
4384
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
11.0
13.5
25
23
R26.0
ICD-10 Finland
Ataxic gait
10.1
13.5
26
26
2132
FHL
Ventricular operators sunt
141.0
13.5
14
*
S01.0
ICD-10 Finland
Open wound of scalp
1.9
13.2
180
1003
Z11
ICPC
Compliance/being ill problem
4.8
13.1
29
61
Z02.7
ICD-10 Finland
Issue of medical certificate
2.0
13.1
145
753
SPAT1244
SPAT
Occupational therapy
4.2
13.0
34
82
G04BD11
ATC
fesoterodine; oral
2.5
12.9
80
327
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
50.4
12.8
15
*
G04BD10
ATC
darifenacin; oral
4.7
12.8
29
62
G30.0
ICD-10 Finland
Alzheimer disease with early onset
4.0
12.7
36
92
N06AB03
ATC
fluoxetine; oral
1.8
12.7
196
1135
N05AF03
ATC
chlorprothixene; systemic
3.6
12.7
42
120
Z08
ICPC
Social welfare problem
4.7
12.6
29
63
J01MA02
ATC
ciprofloxacin; systemic
1.4
12.6
751
5959
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.8
12.6
215
1284
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
12.5
12
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.3
12.5
93
413
AAA10
NOMESCO Finland
Biopsy through craniotomy
130.9
12.4
13
*
SPAT1262
SPAT
Handing over of treatment supplies
1.6
12.4
367
2522
N06DA04
ATC
galantamine; oral
2.4
12.4
87
377
359
Kela drug reimbursment
Mirabegroni
4.8
12.1
27
57
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.1
12.1
49
159
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
12.1
565
4270
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.3
11.9
90
402
N80
ICPC
Head injury other
2.9
11.5
52
180
G91
ICD-10 Finland
Hydrocephalus
+∞
11.5
11
*
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
11.5
11
*
P03
ICPC
Feeling depressed
2.2
11.3
92
424
N05AA02
ATC
levomepromazine; systemic
2.5
11.3
70
286
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
8.4
11.3
24
29
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
2.9
11.3
51
177
130
Kela drug reimbursment
Malignant tumour
0.4
11.3
49
1258
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
3.2
11.3
43
135
J01DB01
ATC
cefalexin; oral
1.5
11.2
1362
12167
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.8
11.2
25
53
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.6
11.2
269
3948
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
4.2
11.1
29
70
SPAT1139
SPAT
Nutrition survey
2.3
11.1
83
370
N05BA01
ATC
diazepam; systemic, rectal
1.7
11.1
243
1552
188
Kela drug reimbursment
Psychosis requiring demanding treatment
8.6
11.0
23
27
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
10.9
662
5229
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
10.9
299
2016
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.7
10.8
56
209
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
10.8
196
1189
183
Kela drug reimbursment
Lamotrigin and topiramate
5.6
10.7
20
36
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.9
10.6
137
750
G72.8
ICD-10 Finland
Other specified myopathies
2.9
10.6
50
178
2133
FHL
Suntin revisio
110.6
10.4
11
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
5.5
10.4
20
37
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.4
10.4
71
304
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
9.6
10.3
20
21
-2, ,
ICPC
4.7
10.2
23
49
A27
ICPC
Fear of other disease NOS
2.1
10.2
103
517
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
2.8
10.1
50
183
S06.3
ICD-10 Finland
Focal brain injury
3.6
9.9
32
90
F20.9
ICD-10 Finland
Schizophrenia, unspecified
3.7
9.9
30
81
P76
ICPC
Depressive disorder
2.5
9.8
62
256
N05AC02
ATC
thioridazine; oral
3.1
9.8
39
126
P99
ICPC
Psychological disorders other
3.5
9.8
33
96
ZXA00
NOMESCO Finland
Right side
1.4
9.6
532
4121
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.6
9.5
239
3494
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
7.2
9.5
22
31
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.2
9.5
36
113
C91.2
ICD-10 Finland
Subacute lymphocytic leukemia
+∞
9.4
9
*
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.7
9.4
170
1031
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
8.1
9.3
20
25
F31
ICD-10 Finland
Bipolar affective disorder
8.1
9.3
20
25
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
4.0
9.3
26
66
N06AX21
ATC
duloxetine; oral
1.7
9.3
167
1010
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
0.6
9.3
194
2959
R41.3
ICD-10 Finland
Other amnesia
2.1
9.3
85
412
SPAT1279
SPAT
Preparation of immediate hospitalisation
3.0
9.2
40
136
SPAT1157
SPAT
Guidance concerning treatment of mouth and mucous membranes
3.2
9.2
35
110
N39.8
ICD-10 Finland
Other specified disorders of urinary system
4.2
9.2
24
58
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
4.6
9.1
21
46
G21.8
ICD-10 Finland
Other secondary parkinsonism
15.7
9.0
14
9
R11
ICD-10 Finland
Nausea and vomiting
1.7
9.0
161
972
K91
ICPC
Cerebrovascular disease
2.9
9.0
42
149
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
3.9
9.0
26
68
S72.0
ICD-10 Finland
Fracture of neck of femur
1.8
8.9
127
717
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
3.7
8.9
27
73
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.4
8.9
62
269
-, ,
ICD-10 Finland
2.5
8.8
53
214
I62.9
ICD-10 Finland
Intracranial haemorrhage (nontraumatic), unspecified
10.7
8.8
16
15
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
8.8
293
2056
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.4
8.8
30
88
R33
ICD-10 Finland
Retention of urine
1.6
8.7
204
1321
Y96.9
ICD-10 Finland
Unspecified type of accident
3.1
8.7
36
119
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
3.1
8.5
34
110
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
8.5
310
2213
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.1
8.5
84
419
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
10.1
8.5
16
16
N06AX03
ATC
mianserin; oral
2.0
8.5
90
461
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
2.6
8.4
48
189
I95.1
ICD-10 Finland
Orthostatic hypotension
1.9
8.4
107
583
2124
FHL
Intracranial pressure measurement, intraventricular
90.5
8.4
9
*
SPAT1240
SPAT
Therapeutic discussion
1.9
8.4
104
563
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
8.3
267
1858
G41.2
ICD-10 Finland
Complex partial status epilepticus
14.5
8.2
13
9
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.4
8.0
53
224
Z29
ICPC
Social problem NOS
2.6
8.0
44
170
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.3
8.0
56
243
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.1
8.0
73
354
H02AB02
ATC
dexamethasone; systemic
0.5
8.0
63
1276
SPAT1138
SPAT
Guidance concerning bowel function
2.7
8.0
42
159
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
3.0
8.0
35
120
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
2.4
7.9
51
213
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.8
7.9
114
647
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.1
7.9
73
356
Z60.8
ICD-10 Finland
Other problems related to social environment
7.8
7.9
17
22
N06AA06
ATC
trimipramine; systemic
2.5
7.9
46
184
S70.0
ICD-10 Finland
Contusion of hip
1.9
7.8
90
476
E0000UV, ,
ATC
1.3
7.8
648
5319
N05CD07
ATC
temazepam; oral
1.5
7.7
266
1876
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
7.7
420
3223
SPAT1263
SPAT
Sampling
1.3
7.7
706
5872
F0019, G301,
ICD-10 Finland
3.1
7.7
31
101
S82
ICPC
Naevus/mole
0.5
7.7
73
1388
SPAT1276
SPAT
Outlining of treatment with patient or their family members
2.3
7.7
58
261
A01
ICPC
Pain general/multiple sites
1.6
7.6
165
1048
SPAT1050
SPAT
Extensive neurological examination
2.4
7.6
50
211
P01
ICPC
Feeling anxious/nervous/tense
2.0
7.6
80
410
L57.0
ICD-10 Finland
Actinic keratosis
0.6
7.6
112
1868
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
2.4
7.6
50
212
SPAT1172
SPAT
Guidance concerning hydration
2.1
7.4
66
317
XKD00
NOMESCO Finland
Uroflowmetry
1.4
7.4
350
2619
G04CB01
ATC
finasteride; oral
1.5
7.4
277
1985
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
3.5
7.4
25
73
A04AA02
ATC
granisetron; systemic, transdermal
0.3
7.4
20
646
2139
FHL
Other measure in this category
+∞
7.3
7
*
2130
FHL
Ventricular atrial shunt
+∞
7.3
7
*
P29
ICPC
Psychological sympt/compl other
2.2
7.3
62
293
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
9.4
7.3
14
15
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.6
7.2
160
2418
G30
ICD-10 Finland
Alzheimer disease
2.5
7.1
43
175
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
3.8
7.1
21
56
N06AG02
ATC
moclobemide; oral
2.0
7.1
69
344
R50.9
ICD-10 Finland
Fever, unspecified
1.5
7.0
251
1782
SPAT1014
SPAT
Treatment of eyes
2.3
7.0
49
213
A69
ICPC
General and Unspecified, Other reason for encounter NEC
2.1
7.0
61
291
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
0.5
7.0
68
1282
N06AB05
ATC
paroxetine; oral
2.0
7.0
70
353
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
5.9
6.9
18
31
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.6
6.9
37
142
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
13.8
6.9
11
8
A10AB05
ATC
insulin aspart; parenteral
1.6
6.9
145
916
N05BA06
ATC
lorazepam; systemic, sublingual
1.8
6.8
105
608
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
2.3
6.8
47
203
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.0
6.8
69
350
N03AF01
ATC
carbamazepine; oral, rectal
1.8
6.7
99
566
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
3.0
6.7
29
99
SPAT1235
SPAT
Mental health, emotional support
6.4
6.6
16
25
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.5
6.6
41
169
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
6.6
444
3514
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.7
6.6
228
3151
N03AX18
ATC
lacosamide; systemic
5.9
6.6
17
29
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
12.3
6.6
11
9
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.5
6.6
179
1201
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
3.2
6.6
25
79
G44.2
ICD-10 Finland
Tension-type headache
1.6
6.6
172
1144
XKD03
NOMESCO Finland
Urethral pressure profilometry
2.3
6.6
47
207
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
2.4
6.6
43
182
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
6.5
537
4378
SPAT1153
SPAT
Removal of sutures
1.3
6.5
564
4634
M54.5
ICD-10 Finland
Low back pain
1.3
6.4
504
4077
N03AF02
ATC
oxcarbazepine; oral
2.2
6.4
52
241
AA1ED
NOMESCO Finland
Trauma CT of head and neck
3.9
6.4
18
46
F25
ICD-10 Finland
Schizoaffective disorders
70.1
6.4
7
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.3
6.4
23
70
I62.1
ICD-10 Finland
Nontraumatic extradural haemorrhage
14.4
6.4
10
7
S22.3
ICD-10 Finland
Fracture of rib
1.6
6.4
131
822
Z43.5
ICD-10 Finland
Attention to cystostomy
3.6
6.3
20
56
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
6.3
172
1155
P72
ICPC
Schizophrenia
3.2
6.3
24
76
G90.2
ICD-10 Finland
Horner syndrome
9.3
6.3
12
13
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
6.3
6
*
N02AA05
ATC
oxycodone; systemic
1.4
6.2
386
3015
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
7.0
6.2
14
20
E000001, ,
ATC
1.4
6.2
288
2145
G31.0
ICD-10 Finland
Circumscribed brain atrophy
3.7
6.2
19
52
N01
ICPC
Headache
1.7
6.2
113
688
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.7
6.2
198
2778
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.2
6.2
10
432
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.3
6.2
400
3146
207
Kela drug reimbursment
Chronic arrhythmias
0.7
6.1
221
3034
R30.1
ICD-10 Finland
Vesical tenesmus
2.5
6.1
38
157
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
1.7
6.1
97
568
F31.8
ICD-10 Finland
Other bipolar affective disorders
4.1
6.1
16
39
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
6.0
647
5452
N05AD01
ATC
haloperidol; systemic
2.0
6.0
63
323
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.5
6.0
162
1085

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
231
106
24.80
318.43
1.5
1.2
—
—
—
0
0
341
89
46.87
307.65
1.1
1.0
244.91
348.68
ng/l
1.77
103
59
618
236
39.04
307.65
1.9
1.3
1487.15
950.05
e6/l
0.21
546
186
639
276
35.05
307.65
1.8
1.2
379.80
602.17
mg/l
7.55
631
254
330
110
36.38
307.65
1.5
1.3
—
—
—
0
0
461
253
24.02
307.65
1.9
1.1
3.93
3.93
mmol/l
0.01
450
230
342
89
47.03
307.65
1.1
1.0
555.11
612.32
ng/l
0.60
103
57
617
236
38.94
307.65
1.9
1.2
6.70
51.93
e6/l
1.02
528
177
394
217
22.87
307.65
1.5
1.2
—
—
—
0
0
180
110
18.04
217.17
1.4
1.4
—
—
—
0
0
106
49
22.90
144.25
1.6
1.1
44.40
65.71
%
—
5
7
89
31
30.13
134.10
1.5
1.1
14.08
16.40
%
—
12
5
66
20
34.20
103.52
1.2
1.2
29.57
61.80
%
—
30
5
403
1461
3.26
85.77
4.0
3.8
—
—
—
0
0
689
3594
2.47
71.09
5.8
4.2
—
—
—
0
0
638
3271
2.46
67.75
6.6
4.8
1.02
1.02
kg/l
0.05
50
535
709
4051
2.23
56.29
6.2
4.7
0.00
0.00
estimate
0.50
139
1302
885
5757
2.04
47.79
5.6
4.0
5.79
5.86
ph
0.10
12
192
94
187
5.24
45.04
4.9
3.6
390.56
343.81
umol/l
2.01
83
158
177
576
3.30
43.56
3.2
3.8
3.82
3.94
mmol/l
2.50
177
569
188
683
2.95
38.21
3.1
3.5
1.50
1.43
mmol/l
0.34
188
668
201
759
2.85
38.06
3.4
4.3
—
—
—
0
0
642
3972
1.95
37.64
1.8
1.8
1424.58
1179.81
nmol/l
9.50
520
2900
779
5157
1.89
37.03
2.6
2.2
269.40
242.65
u/l
0.23
718
4793
620
3918
1.88
33.21
3.1
4.0
87.66
82.75
%
5.61
589
3821
834
5876
1.77
30.51
4.3
3.7
—
—
—
0
0
983
7289
1.75
29.82
5.9
4.3
0.00
0.00
estimate
1.15
156
1521
981
7356
1.72
27.81
5.9
4.4
0.00
0.00
estimate
0.50
139
1351
549
3512
1.80
27.21
2.6
3.1
2.45
2.47
mmol/l
1.51
484
3061
965
7255
1.70
26.64
7.0
5.8
0.00
0.00
estimate
-0.00
145
1373
232
1125
2.22
25.41
3.8
8.1
0.76
0.68
%
2.09
232
1116
231
1119
2.22
25.36
3.8
8.2
93.95
93.93
%
0.01
231
1111
1289
10559
1.75
25.23
6.9
5.4
1600.95
1723.01
e6/l
0.04
22
182
323
1787
1.98
24.88
2.6
2.5
4.55
6.22
ug/l
1.80
274
1508
238
1199
2.13
23.60
5.8
6.2
24.65
24.55
mmol/l
0.15
233
1131
892
6803
1.61
21.46
4.3
4.4
50.14
69.98
ng/l
0.61
736
5397
1161
9537
1.60
19.60
4.8
4.8
7.04
6.91
mmol/l
1.22
1121
9012
238
1281
1.99
19.56
3.6
4.2
—
—
—
0
0
116
463
2.61
19.53
12.7
11.8
—
—
—
0
0
292
1729
1.82
17.83
4.1
7.1
124.84
119.89
g/l
4.06
286
1673
543
3859
1.58
16.51
1.8
1.8
465.72
10581411.74
pmol/l
1.51
463
3081
310
1911
1.75
16.42
4.0
6.6
95.95
95.34
%
1.27
304
1823
749
5788
1.50
15.17
2.4
3.4
2.36
2.35
mmol/l
0.52
649
4918
334
2152
1.68
14.94
3.9
6.3
5.05
5.08
kpa
0.21
327
2025
333
2153
1.67
14.68
3.9
6.3
12.51
11.67
kpa
1.82
325
2028
210
3472
0.55
14.48
3.4
3.4
—
—
—
0
0
684
5265
1.48
13.76
4.3
4.4
—
—
—
0
0
914
7457
1.45
13.49
3.7
4.6
35.00
34.36
g/l
3.18
841
6853
327
2151
1.63
13.37
4.0
6.3
1.39
1.20
mmol/l
0.43
256
1680
430
5825
0.66
12.60
2.1
2.3
—
—
—
0
0
1023
8606
1.43
12.29
13.6
20.6
1.28
1.40
inr
2.86
205
2384
522
3887
1.48
12.08
2.1
2.5
—
—
—
0
0
647
5068
1.43
11.30
2.3
2.6
—
—
—
0
0
860
7124
1.39
10.68
2.5
2.8
—
—
—
0
0
544
6835
0.71
9.89
5.0
5.7
2.91
2.81
%
0.44
489
6311
557
6970
0.71
9.88
5.2
5.9
26.33
25.44
%
1.07
497
6452
546
6846
0.71
9.76
5.1
5.7
57.99
59.09
%
1.21
491
6338
550
6858
0.72
9.39
5.3
6.0
8.96
9.00
%
0.11
493
6340
1023
11590
0.73
9.37
21.7
21.6
15.47
15.54
%
0.12
1006
11345
531
6656
0.72
9.35
5.0
5.7
0.65
0.64
%
0.27
476
6142
921
7828
1.36
9.22
4.8
5.9
1.20
1.21
mmol/l
4.66
846
7034
17
19
9.02
8.53
11.9
16.0
1067.24
1710.95
nmol/l
1.27
17
19
867
7410
1.32
7.88
2.2
2.2
92.39
92.56
pmol/l
0.04
468
3753
265
3664
0.68
7.85
1.5
1.6
1.39
1.30
mmol/l
1.13
230
2988
1204
10861
1.32
7.03
26.5
24.8
331.10
330.70
g/l
0.76
1170
10731
124
1973
0.60
6.96
3.6
4.0
4.79
25.06
ug/l
3.04
100
1651
357
2713
1.39
6.89
1.6
1.9
28.74
30.12
s
5.16
351
2621
407
5114
0.74
6.67
4.5
4.6
—
—
—
0
0
141
892
1.63
6.65
2.0
2.4
0.71
0.64
%
1.36
141
886
555
4542
1.32
6.56
1.6
1.6
20.33
20.13
nmol/l
0.09
493
3786
136
2067
0.63
6.26
1.2
1.2
—
—
—
0
0
56
1063
0.51
5.89
1.4
1.6
—
—
—
0
0
133
1967
0.65
5.38
1.2
1.4
—
—
—
0
0
1182
12774
0.79
5.35
4.0
4.2
1.35
1.26
mmol/l
5.06
1044
11158
450
3693
1.29
5.00
2.9
2.7
5.19
4.90
e6/l
0.19
411
3337
960
8612
1.24
4.94
5.3
6.7
1.20
1.21
mmol/l
2.58
843
7253
103
1580
0.63
4.93
1.2
1.3
—
—
—
0
0
1149
10525
1.25
4.84
3.9
3.9
15.78
15.20
pmol/l
11.11
1026
9203
7
270
0.26
4.71
1.3
1.4
—
—
—
0
0
130
1841
0.68
4.23
2.4
3.1
171.91
257.87
ng/l
2.41
112
1689
20
73
2.76
4.19
1.1
1.1
146.65
132.99
nmol/l
0.49
20
73
202
1517
1.37
4.14
2.4
2.9
4.29
4.44
kpa
0.53
193
1466
1239
13192
0.81
4.09
4.3
4.8
1.39
1.44
mmol/l
3.82
1115
11664
1481
14064
1.28
4.09
20.4
18.3
27.52
27.76
mg/l
0.10
1305
11662
36
685
0.52
3.90
1.8
3.1
18.99
6086.36
u/ml
0.88
28
585
124
1744
0.69
3.89
2.4
2.6
10.46
9.90
umol/l
0.06
99
1527
362
2977
1.27
3.87
3.1
3.0
1.88
1.30
e6/l
0.80
227
1755
361
4336
0.79
3.83
2.6
3.1
30.15
35.69
u/l
2.61
337
4098
6
222
0.27
3.77
6.8
3.9
41.17
37.82
u/ml
—
6
216
1259
13344
0.82
3.74
4.4
4.8
4.30
4.38
mmol/l
1.84
1139
11902
1305
13781
0.81
3.73
5.0
5.5
2.47
2.51
mmol/l
0.80
1177
12237
22
90
2.46
3.72
2.4
1.6
0.71
3.31
u/field
2.68
14
61
599
6794
0.82
3.65
5.2
6.0
—
—
—
0
0
14
45
3.13
3.65
1.2
1.2
—
—
—
0
0
21
85
2.49
3.63
1.7
1.6
10.57
9.91
mmol/l
0.19
21
85
11
25
4.42
3.62
2.4
2.2
38.55
40.00
umol/l
0.07
11
20
60
967
0.61
3.60
5.8
4.1
—
—
—
0
0
193
2491
0.75
3.57
2.4
2.6
19.85
21.55
%
1.07
159
2097
79
1191
0.65
3.54
1.5
1.5
—
—
—
0
0
144
1935
0.72
3.47
1.2
1.2
15.14
15.35
u/ml
0.01
56
626
661
5858
1.20
3.42
4.4
4.0
158.84
129.08
e6/l
0.17
496
4340
206
2617
0.76
3.40
2.2
2.5
2.26
2.26
g/l
0.02
184
2390
178
2301
0.75
3.33
1.4
1.5
2.77
2.76
g/l
0.02
99
1300
524
4556
1.21
3.30
3.6
3.4
—
—
—
0
0
102
712
1.46
3.21
1.3
1.3
83.20
56.19
au/ml
—
5
41
9
250
0.36
3.18
1.2
1.5
—
—
—
0
0
546
4783
1.20
3.16
3.6
3.4
0.52
0.54
e6/l
0.05
439
3736
28
138
2.04
3.11
3.3
3.0
—
—
—
0
0
582
5134
1.20
3.11
3.2
4.0
7.39
7.40
ph
0.45
92
955
155
2019
0.75
3.06
1.3
1.2
55.88
39.56
iu/ml
0.44
47
639
229
1841
1.28
2.94
1.7
1.8
—
—
—
0
0
191
1502
1.30
2.91
3.6
7.3
—
—
—
0
0
1114
10424
1.18
2.87
4.5
4.5
—
—
—
0
0
292
3485
0.81
2.85
3.7
4.2
382.55
328.00
ng/l
0.13
247
3081
17
371
0.45
2.82
1.3
1.2
—
—
—
0
0
355
4139
0.82
2.75
2.5
2.9
1920.86
7187.93
umol/l
3.67
288
3477
41
670
0.60
2.67
1.1
1.3
—
—
—
0
0
13
49
2.66
2.62
1.3
1.1
733.40
99.27
ng/l
—
5
11
15
61
2.47
2.62
2.9
2.0
54.30
48.19
umol/l
—
10
47
399
3451
1.20
2.60
1.3
1.3
—
—
—
0
0
1124
10567
1.17
2.59
5.7
4.9
—
—
—
0
0
98
1333
0.72
2.59
1.9
2.0
135.88
158.05
ug/g
0.48
75
1038
108
1441
0.73
2.53
2.5
2.3
30.17
35.58
u/l
1.37
90
1205
673
6101
1.16
2.49
2.6
3.2
1119.62
1881.89
ng/l
7.35
571
5324
1478
14234
1.20
2.45
17.8
17.7
—
—
—
0
0
1269
13280
0.85
2.45
6.9
6.8
42.62
41.28
mmol/mol
4.72
1172
11938
83
1148
0.71
2.44
4.0
3.4
—
—
—
0
0
5
160
0.31
2.41
1.0
1.1
1.63
1.61
g/l
—
5
144
10
249
0.40
2.34
1.3
1.6
—
—
—
0
0
11
39
2.83
2.34
1.0
1.8
—
—
—
0
0
16
331
0.48
2.34
1.2
1.1
—
96.09
—
0
23
566
6264
0.86
2.32
10.1
10.6
0.00
0.00
e9/l
0.07
467
5073
124
1599
0.76
2.31
1.8
2.0
0.20
0.20
g/l
0.36
107
1478
9
28
3.22
2.30
1.0
1.1
2032.78
1683.39
miu/ml
—
9
28
1318
13725
0.86
2.25
5.1
5.2
6.26
6.13
mmol/l
2.51
1183
12055
238
2828
0.82
2.22
2.2
2.6
10.96
11.87
umol/l
1.35
217
2606
12
270
0.44
2.21
1.5
1.3
24579.86
76675.56
e6/l
—
7
158
13
54
2.42
2.20
1.0
1.7
—
—
—
0
0
7
180
0.39
2.16
1.7
1.6
—
—
—
0
0
321
3696
0.84
2.13
4.8
4.1
—
—
—
0
0
60
854
0.69
2.11
4.6
3.9
—
—
—
0
0
18
342
0.52
2.07
1.2
1.2
—
789.00
—
0
10
5
10
5.01
2.07
1.0
3.4
—
—
—
0
0
688
7462
0.87
2.05
5.1
5.5
0.21
0.19
e9/l
1.15
592
6412
25
430
0.58
2.05
1.7
1.6
—
—
—
0
0
52
351
1.50
2.03
1.6
2.5
26.95
33.55
umol/l
2.10
43
305
15
70
2.15
1.98
1.0
1.6
—
—
—
0
0
300
3451
0.84
1.97
2.8
3.4
0.69
0.81
ug/l
1.94
212
2515
123
1551
0.78
1.96
1.2
1.3
960.00
556.22
titre
0.78
21
360
216
1812
1.22
1.95
2.7
3.5
5.86
5.82
kpa
0.19
206
1755
5
11
4.55
1.94
1.2
1.8
18.14
15.45
umol/l
—
5
11
6
156
0.38
1.89
1.0
1.2
—
—
—
0
0
542
4919
1.14
1.89
2.3
2.5
61.15
76.72
u/l
0.43
491
4490
61
841
0.72
1.82
1.3
1.3
—
—
—
0
0
14
66
2.13
1.82
1.1
1.2
—
—
—
0
0
11
234
0.47
1.80
1.7
1.4
—
—
—
0
0
62
849
0.72
1.78
2.2
1.7
1.24
1.55
g/l
0.65
51
752
49
338
1.46
1.76
1.1
1.3
—
—
—
0
0
14
67
2.10
1.76
1.0
1.6
—
—
—
0
0
29
454
0.63
1.68
2.9
2.8
—
—
—
0
0
14
267
0.52
1.68
2.4
2.7
—
—
—
0
0
212
1805
1.20
1.67
2.7
3.5
2.28
2.01
mmol/l
0.59
178
1489
15
279
0.53
1.66
1.5
2.4
—
—
—
0
0
51
711
0.71
1.65
5.3
4.1
25.28
24.86
mmol/l
0.40
45
649
14
69
2.04
1.64
1.0
1.6
—
—
—
0
0
49
686
0.71
1.63
1.2
1.2
—
—
—
0
0
10
42
2.39
1.61
1.1
2.1
—
—
—
0
0
12
56
2.15
1.61
1.9
1.9
13.31
15.96
nmol/l
0.85
12
50
37
543
0.67
1.59
7.3
5.1
—
—
—
0
0
14
70
2.01
1.59
1.0
1.6
—
—
—
0
0
14
70
2.01
1.59
1.0
1.6
—
—
—
0
0
673
7220
0.89
1.57
4.8
5.3
0.62
0.63
e9/l
0.19
575
6112
675
7239
0.89
1.56
4.8
5.3
0.04
0.04
e9/l
0.28
576
6136
13
247
0.52
1.56
1.5
1.4
—
—
—
0
0
81
1040
0.77
1.54
1.2
1.5
—
—
—
0
0
102
1270
0.79
1.51
6.3
4.6
—
—
—
0
0
25
394
0.63
1.51
1.2
1.2
—
—
—
0
0
9
182
0.49
1.51
1.2
1.2
—
—
—
0
0
0
45
0.00
1.50
0.0
1.2
—
150.02
—
0
45
74
956
0.76
1.48
1.4
1.7
1.57
1.53
g/l
0.17
63
815
11
212
0.52
1.40
1.5
4.1
—
—
—
0
0
692
7377
0.90
1.40
5.1
5.5
1.88
1.88
e9/l
0.01
590
6397
6
138
0.43
1.40
1.0
1.3
—
—
—
0
0
86
1080
0.79
1.39
1.3
1.4
—
—
—
0
0
9
181
0.49
1.39
1.2
1.1
—
—
—
0
0
560
6030
0.90
1.36
2.5
2.9
140.07
156.08
ug/l
0.98
501
5390
84
664
1.28
1.35
2.1
2.1
727.67
897.94
ug/l
0.17
75
623
0
38
0.00
1.34
0.0
1.3
—
70.73
—
0
28
0
38
0.00
1.34
0.0
2.9
—
14.56
—
0
33
70
897
0.77
1.34
1.1
1.2
—
—
—
0
0
0
39
0.00
1.33
0.0
6.7
—
—
—
0
0
1136
10921
1.11
1.31
3.6
4.3
15.75
15.22
mm/h
0.47
1013
9904
0
41
0.00
1.31
0.0
1.0
—
277.46
—
0
28
50
369
1.36
1.30
1.6
1.3
70.73
59.93
mmol/l
1.22
44
298
1436
14715
0.89
1.30
10.0
11.5
23.90
23.89
u/l
0.00
1366
14011
96
1179
0.80
1.29
4.3
3.8
5.23
5.17
kpa
0.30
88
1110
89
1099
0.80
1.27
1.3
1.4
—
—
—
0
0
559
5195
1.11
1.26
3.9
3.5
78.36
86.34
e6/l
0.13
440
4082
102
1239
0.81
1.25
3.1
3.9
0.48
0.10
%
0.59
23
433
5
118
0.42
1.24
1.4
1.1
—
—
—
0
0
8
36
2.23
1.24
1.3
1.1
—
—
—
0
0
74
931
0.79
1.24
2.9
3.3
12.14
4.94
e9/l
0.67
52
662
5
119
0.42
1.24
1.2
1.6
—
—
—
0
0
77
964
0.79
1.24
2.6
2.5
—
—
—
0
0
97
1183
0.81
1.24
3.1
3.8
1.36
0.70
%
0.65
22
433
804
8469
0.91
1.24
7.6
8.5
4.55
4.36
e9/l
1.29
696
7304
95
1160
0.81
1.23
4.3
3.8
7.39
7.41
ph
0.63
14
143
23
347
0.66
1.19
1.1
1.1
—
—
—
0
0
63
491
1.29
1.16
1.5
1.9
20.25
21.97
s
1.41
57
445
14
234
0.60
1.13
1.3
1.1
—
—
—
0
0
210
2368
0.87
1.10
1.9
2.4
1.74
1.81
%
0.45
175
2062
87
1056
0.82
1.09
2.6
2.8
10.37
10.73
g/l
0.43
78
949
32
227
1.42
1.08
5.5
6.1
8.40
7.63
mmol/l
0.32
22
190
16
97
1.66
1.06
1.9
1.9
—
—
—
0
0
8
148
0.54
1.03
1.0
1.2
—
60.67
—
0
8
1519
14898
1.12
1.00
24.4
22.1
139.56
139.51
mmol/l
0.23
1470
14481
20
297
0.67
0.99
1.3
1.3
—
—
—
0
0
1320
12861
1.09
0.99
5.0
4.9
1.98
2.06
mu/l
1.44
1195
11357
7
135
0.52
0.98
1.4
1.2
—
—
—
0
0
98
1161
0.84
0.97
3.1
3.9
0.21
0.33
%
0.18
19
360
25
173
1.45
0.97
2.3
2.2
3.25
1.84
u/field
0.43
12
51
148
1694
0.86
0.97
1.3
1.4
—
—
—
0
0
10
174
0.57
0.96
1.1
1.2
—
—
—
0
0
39
513
0.76
0.96
3.8
3.3
—
—
—
0
0
1520
14920
1.11
0.95
24.2
22.3
3.98
4.01
mmol/l
4.46
1468
14481
56
444
1.27
0.94
1.7
2.3
149.01
84.12
ug/min
0.44
25
258
12
196
0.61
0.92
1.3
1.3
—
—
—
0
0
14
220
0.63
0.92
1.1
1.3
—
—
—
0
0
8
42
1.91
0.88
1.0
1.2
—
—
—
0
0
186
1662
1.13
0.86
2.4
2.6
67.14
65.99
g/l
1.37
166
1493
234
2571
0.90
0.83
1.2
1.2
0.95
1.46
u/ml
1.00
79
624
8
137
0.58
0.83
1.5
1.4
—
—
—
0
0
16
237
0.67
0.82
1.3
1.2
—
—
—
0
0
12
189
0.63
0.81
1.0
1.2
—
—
—
0
0
120
1372
0.87
0.81
1.2
1.4
—
—
—
0
0
127
1445
0.87
0.80
2.5
3.6
74.18
98.32
ng/l
4.02
107
1207
0
24
0.00
0.79
0.0
1.3
—
6.84
—
0
13
511
5400
0.93
0.79
3.5
3.8
11.67
9.00
mg/mmol
0.48
375
3420
481
5095
0.92
0.79
3.1
3.3
543.18
284.54
mg/l
0.53
362
3268
115
1316
0.87
0.79
3.0
3.9
2.73
0.87
%
1.19
35
508
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
0.41
—
0
10
26
191
1.37
0.77
2.2
2.2
—
—
—
0
0
16
232
0.69
0.75
1.0
1.1
—
—
—
0
0
46
569
0.80
0.74
3.0
3.3
0.75
0.82
nmol/l
0.73
41
440
25
335
0.74
0.74
1.1
1.5
—
—
—
0
0
9
54
1.67
0.74
1.4
1.4
—
—
—
0
0
15
219
0.68
0.73
2.1
1.7
44.13
47.64
nmol/l
0.18
15
203
13
195
0.66
0.72
1.1
1.0
—
—
—
0
0
36
456
0.79
0.72
4.4
3.6
7.02
7.93
mmol/l
2.05
36
447
164
1820
0.89
0.72
4.0
4.7
—
—
—
0
0
9
142
0.63
0.69
2.6
1.7
2.90
4.81
mg/l
—
9
137
5
27
1.85
0.68
1.6
1.4
75.86
84.53
ng/l
—
5
27
16
110
1.46
0.68
1.7
1.8
—
—
—
0
0
96
840
1.15
0.65
1.8
1.9
1.11
2.72
ug/l
1.35
82
712
90
784
1.16
0.64
4.3
4.5
0.85
0.87
%
0.24
84
737
21
281
0.74
0.64
3.4
2.7
—
—
—
0
0
12
177
0.68
0.63
1.2
1.2
—
—
—
0
0
91
795
1.15
0.63
4.3
4.4
1.52
1.55
%
0.16
85
747
58
684
0.84
0.61
3.3
3.3
52.85
145.32
mg/l
0.57
50
555
8
50
1.60
0.61
1.8
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
14.8
—
5.91
—
0
20
155
1407
1.11
0.60
2.6
2.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
33
409
0.80
0.58
1.1
1.3
—
21.74
—
0
8
163
1783
0.91
0.58
2.0
2.4
69.24
68.41
e9/l
0.11
124
1379
6
35
1.72
0.57
1.0
1.2
—
—
—
0
0
8
54
1.48
0.57
3.8
2.6
—
—
—
0
0
18
132
1.37
0.57
1.2
1.2
33.78
35.49
mmol/l
0.13
18
114
8
55
1.46
0.56
1.6
1.2
—
—
—
0
0
5
89
0.56
0.56
1.4
1.3
1434.00
1735.95
ml
—
5
84
57
666
0.85
0.56
3.2
3.3
1.77
1.86
ratio
—
9
45
6
37
1.62
0.55
1.0
1.2
—
—
—
0
0
256
2391
1.08
0.55
1.7
2.0
—
—
—
0
0
33
406
0.81
0.55
1.4
1.6
22206.00
16254.83
e6/l
0.23
22
289
59
684
0.86
0.53
3.3
3.3
30.72
80.97
mg/l
1.60
52
558
21
271
0.77
0.52
1.2
1.4
—
—
—
0
0
24
304
0.79
0.52
1.4
1.5
—
—
—
0
0
77
873
0.88
0.52
2.6
3.5
24.67
24.05
mmol/l
0.99
72
850
9
135
0.67
0.51
1.0
1.1
—
—
—
0
0
109
1207
0.90
0.50
1.3
1.5
—
—
—
0
0
50
428
1.17
0.48
1.2
1.2
—
—
—
0
0
856
8338
1.05
0.48
3.9
6.1
11.43
12.42
umol/l
1.11
797
7876
23
288
0.80
0.47
4.0
3.1
63.43
59.53
%
0.60
23
288
21
265
0.79
0.45
1.1
1.4
0.68
0.85
nmol/l
0.87
16
212
22
276
0.79
0.45
2.9
2.9
6.72
4.49
e9/l
1.54
22
276
41
482
0.85
0.45
4.1
3.5
1.62
1.70
mmol/l
0.21
41
474
484
4656
1.05
0.44
2.2
2.3
3.38
3.17
mg/l
0.93
404
3900
6
92
0.65
0.42
1.2
1.4
79.17
65.22
%
—
6
68
71
794
0.89
0.41
2.0
2.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
57.30
—
0
10
0
17
0.00
0.40
0.0
1.1
—
0.36
—
0
7
0
17
0.00
0.40
0.0
1.8
—
—
—
0
0
5
34
1.47
0.40
1.2
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
1.80
—
0
18
7
101
0.69
0.39
2.3
2.9
—
—
—
0
0
24
196
1.23
0.39
2.7
3.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
9.38
—
0
8
5
36
1.39
0.38
1.4
1.4
—
—
—
0
0
243
2308
1.06
0.36
3.8
5.2
1.01
1.03
mmol/l
0.46
217
2111
29
244
1.19
0.36
1.0
1.4
—
—
—
0
0
5
77
0.65
0.35
2.6
1.9
365.60
536.88
e6/l
—
5
67
25
298
0.84
0.35
2.0
2.1
55.43
60.38
%
0.50
25
298
14
178
0.78
0.34
1.4
1.7
—
—
—
0
0
55
615
0.89
0.34
1.3
1.1
82.59
116.22
iu/ml
0.32
25
199
34
393
0.86
0.33
3.9
3.9
28.16
30.00
mg/l
0.11
21
253
154
1639
0.93
0.33
4.5
6.2
9.57
11.39
mmol/l
2.87
144
1541
637
6211
1.04
0.33
2.1
2.2
78.46
79.87
nmol/l
0.57
541
5317
6
88
0.68
0.33
2.0
1.4
145.83
94.07
umol/l
—
6
88
41
466
0.88
0.33
1.4
1.5
—
—
—
0
0
784
8005
0.96
0.32
2.9
3.2
48.78
56.45
u/l
1.66
708
7183
7
98
0.71
0.30
1.1
1.2
—
—
—
0
0
59
533
1.11
0.30
3.3
3.5
—
—
—
0
0
45
401
1.13
0.29
6.0
6.0
11.00
11.14
mmol/l
0.14
39
357
45
401
1.13
0.29
6.0
6.0
105.38
105.10
mmol/l
0.16
39
357
326
3144
1.04
0.29
1.5
1.6
1.68
1.48
mg/l
0.30
257
2454
14
173
0.81
0.28
1.1
1.2
—
—
—
0
0
52
575
0.90
0.28
6.0
5.4
1.39
1.36
mmol/l
0.09
44
501
8
62
1.29
0.28
2.0
1.8
106.63
53.86
ug/l
—
8
57
18
149
1.21
0.27
1.1
1.2
4239.77
143504.02
e6/l
1.25
13
97
62
677
0.91
0.27
2.2
2.1
—
—
—
0
0
1522
15112
1.04
0.26
28.4
27.0
247.12
238.70
e9/l
5.25
1468
14617
1522
15113
1.04
0.26
28.3
26.9
91.40
91.87
fl
3.46
1476
14785
5
73
0.68
0.26
2.6
2.0
0.15
0.21
e9/l
—
5
66
1522
15114
1.04
0.26
28.3
26.9
30.31
30.43
pg
1.77
1478
14785
1522
15114
1.04
0.26
28.4
27.0
7.34
7.00
e9/l
1.89
1469
14545
1522
15115
1.04
0.25
28.5
27.0
4.35
4.35
e12/l
0.12
1464
14553
1522
15115
1.04
0.25
28.4
27.1
39.26
38.82
%
2.11
1411
13811
501
5132
0.97
0.25
3.0
3.2
7.37
6.91
mmol/l
1.71
431
4172
1522
15117
1.04
0.25
28.6
27.2
131.09
131.30
g/l
0.21
1479
14793
378
3672
1.04
0.25
5.4
6.6
—
—
—
0
0
58
632
0.92
0.24
2.6
2.8
0.53
0.29
g/l
0.66
21
233
108
1016
1.07
0.24
4.5
6.7
25.04
24.83
mmol/l
0.28
108
1009
9
77
1.17
0.24
1.1
1.0
—
—
—
0
0
1192
11796
1.03
0.24
5.6
7.7
78.78
81.81
u/l
0.99
1103
10979
369
3589
1.04
0.23
3.5
3.1
533.07
538.87
mosm/kgh2o
0.23
320
3075
0
11
0.00
0.21
0.0
5.3
—
0.32
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
23
262
0.88
0.21
1.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
8
101
0.79
0.21
1.8
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
31
278
1.12
0.20
4.6
2.8
—
—
—
0
0
89
943
0.94
0.20
6.2
8.9
—
—
—
0
0
6
48
1.25
0.20
1.7
1.3
18.95
34.12
u/l
—
6
38
28
313
0.89
0.20
1.9
2.0
—
—
—
0
0
9
113
0.80
0.20
2.9
2.0
1.15
1.08
e9/l
—
9
103
38
416
0.91
0.19
3.2
2.4
131.13
125.45
g/l
0.68
31
301
6
52
1.15
0.19
1.2
1.3
—
—
—
0
0
34
372
0.91
0.17
3.6
3.1
—
—
—
0
0
19
167
1.14
0.17
1.2
1.3
261.18
250.92
pmol/l
0.08
11
140
6
78
0.77
0.15
2.8
4.1
—
—
—
0
0
15
131
1.15
0.14
1.5
2.0
5.04
2.87
ug/l
0.65
15
120
615
6076
1.02
0.13
4.6
5.7
3.33
4.66
ug/l
0.80
529
5333
9
108
0.83
0.13
2.3
2.3
—
—
—
0
0
9
110
0.82
0.13
1.1
1.4
—
30.63
—
0
8
17
190
0.89
0.13
2.1
1.2
0.76
0.66
nmol/l
0.33
17
175
14
123
1.14
0.12
1.6
1.2
—
—
—
0
0
64
610
1.05
0.12
2.4
2.4
38.31
37.11
g/l
1.06
53
520
23
210
1.10
0.12
1.6
2.0
—
—
—
0
0
12
136
0.88
0.11
1.3
1.7
8.66
10.61
%
0.87
12
136
39
413
0.94
0.10
3.6
2.6
16.50
15.53
%
0.74
21
202
21
228
0.92
0.10
1.5
1.5
—
—
—
0
0
37
389
0.95
0.08
1.5
2.3
—
—
—
0
0
10
88
1.14
0.08
1.0
1.2
—
—
—
0
0
132
1291
1.02
0.08
2.2
2.1
361.93
377.73
nmol/l
0.43
117
1156
6
71
0.84
0.07
9.5
6.0
—
—
—
0
0
6
72
0.83
0.07
1.3
1.1
—
—
—
0
0
6
72
0.83
0.07
1.3
1.1
—
—
—
0
0
40
418
0.96
0.07
5.3
5.1
8.41
8.24
kpa
0.33
40
411
7
83
0.84
0.07
3.1
2.0
80.14
71.71
%
—
7
76
31
326
0.95
0.07
1.4
1.2
—
—
—
0
0
16
173
0.92
0.06
1.8
1.2
—
—
—
0
0
43
413
1.04
0.06
5.3
4.1
—
—
—
0
0
40
417
0.96
0.06
5.3
5.1
4.95
5.07
kpa
0.63
40
410
18
193
0.93
0.06
2.9
2.7
—
—
—
0
0
40
416
0.96
0.06
5.3
5.1
2.02
2.77
mmol/l
1.51
35
288
26
273
0.95
0.05
1.7
1.5
5.76
4.67
iu/l
—
7
84
11
120
0.92
0.05
10.2
14.5
—
—
—
0
0
144
1460
0.99
0.04
4.1
3.7
1.23
1.22
mmol/l
0.49
129
1251
34
352
0.97
0.04
1.2
1.8
26.93
12.73
mg/l
0.42
26
319
277
2792
0.99
0.04
3.6
3.2
3.30
2.15
e6/l
0.86
147
1579
11
118
0.93
0.02
1.1
1.3
—
—
—
0
0
46
470
0.98
0.02
1.4
1.5
283.61
269.18
ug/g
0.17
23
281
51
500
1.02
0.02
4.7
4.6
7.43
7.42
ph
0.90
40
444
71
719
0.99
0.01
1.3
1.3
—
—
—
0
0
75
741
1.01
0.01
2.4
2.5
9.85
10.42
g/l
0.88
64
646
69
696
0.99
0.00
3.1
3.0
4.32
4.31
pmol/l
0.01
58
591
19
191
0.99
0.00
2.5
2.1
1.02
1.43
g/24h
—
8
92
16
164
0.98
0.00
2.2
1.2
—
—
nmol/l
—
0
0
15
147
1.02
0.00
1.3
1.6
—
—
—
0
0
271
2705
1.00
0.00
2.1
2.9
0.82
0.81
mmol/l
0.37
241
2493
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
7
73
0.96
0.00
1.0
1.2
8.94
10.07
mmol/l
—
7
67
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
4.60
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
2.4
1.2
6.42
6.45
mmol/l
—
5
58
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
-0.00
3.9
2.5
1608.57
1841.64
ml
—
7
58
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
2.0
1.9
2.68
5.47
nmol/l
—
5
40
0
5
0.00
-0.00
0.0
1.6
—
1.94
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
2.65
—
0
6
6
61
0.98
-0.00
2.3
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
33.20
—
0
5

Mortality – FinRegistry

Association

Association between endpoint G6_HCNP and mortality.

Females

Parameter HR [95% CI] p-value
G6_HCNP 2.238 [2.01, 2.49] < 0.001
Birth year 0.996 [0.99, 1.0] 0.32

During the follow-up period (1.1.1998 — 31.12.2019), 1631 out of 3345 females with G6_HCNP died.

Males

Parameter HR [95% CI] p-value
G6_HCNP 2.381 [2.07, 2.74] < 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1722 out of 3293 males with G6_HCNP died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCNP.

N-year risk Females Males
1 0.211% 0.473%
5 1.38% 2.537%
10 3.1% 6.356%
15 6.083% 11.522%
20 11.154% 18.816%

Relationships between endpoints

Index endpoint: G6_HCNP – Normal-pressure hydrocephalus

GWS hits: 15

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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