Paraplegia, diplegia of upper limbs

G6_PARDIPLE

paraplegia: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord. [database_cross_reference: NCIT:P378]

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

802

4. Check minimum number of events

None

802

5. Include endpoints

None

802

6. Filter based on genotype QC (FinnGen only)

802

Control definitions (FinnGen only)

Control exclude
G6_CPETAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7688 3418 4167
Only index persons 6093 2826 3267
Unadjusted period prevalence (%)
Whole population 0.11 0.10 0.12
Only index persons 0.12 0.10 0.12
Median age at first event (years)
Whole population 56.92 57.26 56.41
Only index persons 54.02 54.33 53.75

-FinnGen-

Key figures

All Female Male
Number of individuals 802 362 440
Unadjusted period prevalence (%) 0.16 0.12 0.19
Median age at first event (years) 54.09 47.41 59.58

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
734
Matched controls
7339
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G82.2
ICD-10 Finland
Paraplegia, unspecified
+∞
323.0
548
*
G82.1
ICD-10 Finland
Spastic paraplegia
+∞
146.9
136
*
G82.0
ICD-10 Finland
Flaccid paraplegia
+∞
118.0
110
*
M03BX01
ATC
baclofen; systemic
48.2
113.6
138
35
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
412.0
109.4
107
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
42.4
89.9
112
31
N18
ICPC
Paralysis/weakness
28.0
78.2
108
45
XKD06
NOMESCO Finland
Physiologic investigation of micturition
18.0
76.9
123
81
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
176.7
76.7
79
5
XKC03
NOMESCO Finland
Water cystometry
16.3
71.1
118
85
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
47.7
63.4
77
18
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
19.6
60.4
93
54
R33
ICD-10 Finland
Retention of urine
6.4
57.6
166
318
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
21.0
57.4
86
46
N03AX16
ATC
pregabalin; oral
4.0
55.9
283
991
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
33.1
54.9
72
24
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
53.3
216
608
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
5.0
53.0
196
501
SPAT1229
SPAT
Assessment of need for aid
6.4
52.1
149
280
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
32.8
50.3
66
22
L28
ICPC
Limited function/disability (L)
4.5
49.5
206
590
UKC02
NOMESCO Finland
Cystoscopy
4.1
48.5
225
712
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.0
46.0
121
201
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.8
45.9
141
287
TKC20
NOMESCO Finland
Catheterisation of bladder
6.5
45.4
127
229
N03AX12
ATC
gabapentin; oral
4.2
44.5
199
602
J01MA12
ATC
levofloxacin; systemic
3.6
41.6
223
784
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
4.1
41.0
184
554
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.7
41.0
210
710
J01EA01
ATC
trimethoprim; systemic
3.3
40.7
257
1023
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
18.7
40.1
62
36
G82.5
ICD-10 Finland
Tetraplegia, unspecified
+∞
40.0
38
*
R1250
NOMESCO Finland
Evaluation of functional capability
15.4
39.0
65
46
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
13.0
38.4
69
58
TAB00
NOMESCO Finland
Lumbar puncture
8.2
38.2
89
122
N03AE01
ATC
clonazepam; systemic
6.2
37.8
108
198
QBG10
NOMESCO Finland
Excision and repair of bedsore of trunk
133.4
36.0
38
*
A28
ICPC
Limited function/disability NOS
3.6
33.9
179
606
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
15.1
33.4
56
40
T91.1
ICD-10 Finland
Sequelae of fracture of spine
51.3
32.8
39
8
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.3
32.5
132
356
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
6.3
32.5
90
158
A06AD11
ATC
lactulose; oral
3.6
32.3
169
568
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
30.3
267
1276
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
71.1
30.1
34
5
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
21.2
29.9
44
22
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.4
29.3
160
552
N02AA05
ATC
oxycodone; systemic
3.3
29.2
168
603
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
14.0
29.1
50
38
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
14.1
28.6
49
37
S97
ICPC
Chronic ulcer skin
5.4
28.6
91
189
AA1AD
NOMESCO Finland
CT of head and brain
2.7
28.2
234
1069
J01MA02
ATC
ciprofloxacin; systemic
2.4
27.5
342
1948
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.7
27.2
97
228
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
26.9
124
371
N02AX02
ATC
tramadol; systemic, rectal
2.4
26.9
363
2144
G95.1
ICD-10 Finland
Vascular myelopathies
145.3
26.8
28
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.5
26.8
137
447
A46
ICD-10 Finland
Erysipelas
3.2
26.6
156
564
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
15.0
26.5
44
31
N30.0
ICD-10 Finland
Acute cystitis
3.4
26.4
143
486
G82.4
ICD-10 Finland
Spastic tetraplegia
+∞
26.2
25
*
S24.0
ICD-10 Finland
Concussion and oedema of thoracic spinal cord
269.6
25.9
26
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
25.7
228
1074
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
25.6
204
901
N30.9
ICD-10 Finland
Cystitis, unspecified
5.6
24.7
74
143
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
19.4
24.6
37
20
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
25.4
24.6
34
14
J01CA08
ATC
pivmecillinam; oral
2.4
24.5
287
1561
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.1
24.4
102
279
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.3
24.2
66
113
M48.0
ICD-10 Finland
Spinal stenosis
3.3
24.1
133
457
34401
ICD-8 Finland
Other cerebral paralysis, Diplegia NUD
+∞
24.1
23
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
6.1
24.0
67
118
XKD03
NOMESCO Finland
Urethral pressure profilometry
9.1
24.0
51
60
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
23.8
262
1374
SPAT1262
SPAT
Handing over of treatment supplies
2.7
23.8
191
841
G83.4
ICD-10 Finland
Cauda equina syndrome
89.8
23.8
26
*
QBG00
NOMESCO Finland
Debridement of bedsore of trunk
89.8
23.8
26
*
N28
ICPC
Limited function/disability (N)
10.6
23.6
46
46
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
23.0
22
*
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
17.1
22.9
36
22
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.9
22.4
152
601
R4120
NOMESCO Finland
Occupational therapy
4.4
22.3
84
208
C03CA01
ATC
furosemide; systemic
2.3
22.2
256
1364
G35
ICD-10 Finland
Multiple sclerosis
12.8
22.0
39
32
R4110
NOMESCO Finland
Physiotherapy
2.4
21.8
239
1239
U07
ICPC
Urine symptom/complaint other
4.6
21.7
78
184
N29
ICPC
Neurological sympt/complt other
11.1
21.6
41
39
N99
ICPC
Neurological disease other
14.5
21.5
36
26
SPAT1231
SPAT
Assessment of adjustments needed in living environment
8.0
21.4
49
65
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
7.8
21.0
49
67
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.7
21.0
74
171
G95.9
ICD-10 Finland
Disease of spinal cord, unspecified
61.9
21.0
24
*
G04BD08
ATC
solifenacin; oral
4.3
20.9
80
201
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.0
20.9
88
242
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
20.9
260
1430
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
20.8
159
676
ABD40
NOMESCO Finland
Implantation of spinal injection device
215.8
20.7
21
*
N06AA09
ATC
amitriptyline; systemic
3.3
20.7
113
382
N06AX21
ATC
duloxetine; oral
3.4
20.5
107
351
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
20.5
168
742
SPAT1167
SPAT
Insertion of urinary catheter
5.7
20.4
60
113
N05BA01
ATC
diazepam; systemic, rectal
2.9
20.4
138
542
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.2
20.0
64
133
N81
ICPC
Injury nervous system other
36.9
19.9
25
7
G04AC01
ATC
NA
7.6
19.6
46
64
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
19.4
125
474
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
26.9
19.2
26
10
SPAT1216
SPAT
Assessment of functional ability
2.7
19.2
145
609
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
56.6
19.0
22
*
J01MA06
ATC
norfloxacin; oral
2.9
19.0
125
482
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
18.9
158
701
J01XX05
ATC
methenamine; oral
24.4
18.7
26
11
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
102.7
18.6
20
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
6.4
18.5
49
81
G04BD04
ATC
oxybutynin; oral, transdermal
4.5
18.4
67
160
R20.2
ICD-10 Finland
Paraesthesia of skin
4.0
18.3
76
206
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
20.0
18.3
27
14
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.8
18.3
62
138
A41.9
ICD-10 Finland
Sepsis, unspecified
5.2
18.2
57
116
NAJ22
NOMESCO Finland
Posterior reduction of fractrue of thoracic spine
33.8
18.0
23
7
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
33.8
18.0
23
7
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
18.0
115
433
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
23.5
17.8
25
11
G83.0
ICD-10 Finland
Diplegia of upper limbs
+∞
17.8
17
*
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
+∞
17.8
17
*
G61.0
ICD-10 Finland
Guillain-Barré syndrome
37.7
17.7
22
6
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
37.7
17.7
22
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
17.3
110
413
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.4
17.2
52
102
R60.0
ICD-10 Finland
Localized oedema
3.0
17.1
106
391
NAJ32
NOMESCO Finland
Posterior reduction of fractrue of lumbar spine
64.9
16.8
19
*
XKD00
NOMESCO Finland
Uroflowmetry
2.4
16.7
158
748
J01XE01
ATC
nitrofurantoin; oral
9.3
16.6
34
38
ZZR10
NOMESCO Finland
Flap of skin and muscle
20.6
16.5
24
12
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
16.5
93
322
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
16.1
169
839
R31
ICD-10 Finland
Unspecified haematuria
2.9
15.8
106
410
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
8.1
15.7
35
45
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
87.0
15.6
17
*
W19
ICD-10 Finland
Unspecified fall
3.0
15.4
94
343
109
Kela drug reimbursment
Multiple sclerosis
11.6
15.4
28
25
SPAT1255
SPAT
Intravenous administration of medicine
3.5
15.4
73
222
S72.4
ICD-10 Finland
Fracture of lower end of femur
16.5
15.3
24
15
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.8
15.2
67
191
J01FF01
ATC
clindamycin; systemic
2.1
15.2
220
1257
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
15.2
91
327
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.0
15.2
42
74
G99.2
ICD-10 Finland
Myelopathy in diseases classified elsewhere
20.6
15.2
22
11
N06AX16
ATC
venlafaxine; oral
2.6
15.2
119
507
U05
ICPC
Urination problems other
4.2
15.2
59
151
K59.0
ICD-10 Finland
Constipation
4.0
15.1
61
162
W17
ICD-10 Finland
Other fall from one level to another
4.2
15.1
58
147
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
57.9
14.8
17
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
14.8
121
525
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.5
14.7
131
595
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.3
14.7
76
247
9072A
ICD-9 Finland
Late effects of injuries to the nervous system, Late effect of spinal cord injury
+∞
14.6
14
*
F44.4
ICD-10 Finland
Dissociative motor disorders
+∞
14.6
14
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.8
14.6
99
386
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.4
14.6
72
226
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.9
14.6
61
167
N06AB04
ATC
citalopram; systemic
2.2
14.5
176
929
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
19.6
14.3
21
11
WX002
NOMESCO Finland
Sedation and analgesia
2.2
14.3
163
836
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
5.2
14.2
44
89
U04
ICPC
Incontinence urine
4.1
14.1
55
141
R53
ICD-10 Finland
Malaise and fatigue
2.2
14.1
164
848
G04BD12
ATC
mirabegron; oral
2.9
14.1
90
339
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
9.3
13.8
28
31
Z43.5
ICD-10 Finland
Attention to cystostomy
13.9
13.8
23
17
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
76.6
13.6
15
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
13.6
165
870
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
13.5
222
1323
NA2AD
NOMESCO Finland
Thoracic spine CT examination
16.6
13.5
21
13
QDG10
NOMESCO Finland
Excision and repair of bedsore of lower limb
142.5
13.5
14
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.9
13.4
44
95
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
26.3
13.4
18
7
U13
ICPC
Bladder symptom/complaint other
5.8
13.3
37
66
N03AF02
ATC
oxcarbazepine; oral
5.3
13.2
40
79
R52.2
ICD-10 Finland
Other chronic pain
4.8
13.2
44
97
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.0
13.1
53
141
B01AB05
ATC
enoxaparin; parenteral
1.9
13.0
229
1396
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.4
13.0
63
195
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
13.3
13.0
22
17
U29
ICPC
Urinary symptom/complaint other
5.2
13.0
40
81
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.7
12.9
94
383
V89
ICD-10 Finland
Motor- or nonmotor-vehicle accident, type of vehicle unspecified
50.9
12.9
15
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
6.1
12.7
34
58
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
6.8
12.6
31
47
SPAT1254
SPAT
Administration of medicine
2.3
12.6
128
622
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.4
12.5
45
107
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
12.5
12
*
3499X
ICD-9 Finland
Other and unspecified disorders of the nervous system, Unspecified disorders of nervous system
+∞
12.5
12
*
S34.0
ICD-10 Finland
Concussion and oedema of lumbar spinal cord
+∞
12.5
12
*
V49.9
ICD-10 Finland
Car occupant [any] injured in unspecified traffic accident
4.3
12.4
46
113
TKC22
NOMESCO Finland
Catheterisation instruction
5.9
12.4
34
60
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.6
12.3
55
160
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
12.2
217
1321
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.3
12.1
120
572
R5110
SPAT
NA
5.5
12.1
35
66
R15
ICD-10 Finland
Faecal incontinence
5.8
11.9
33
59
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
11.9
70
250
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
11.8
93
394
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.7
11.8
52
149
N05CF01
ATC
zopiclone; oral
1.8
11.7
242
1553
S14.0
ICD-10 Finland
Concussion and oedema of cervical spinal cord
66.0
11.6
13
*
NA7DM
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with 3 Tesla magnet
66.0
11.6
13
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.3
11.6
42
101
N21.0
ICD-10 Finland
Calculus in bladder
9.5
11.6
23
25
G04BD07
ATC
tolterodine; oral
3.8
11.5
49
137
N86
ICPC
Multiple sclerosis
13.9
11.5
19
14
G82
ICD-10 Finland
Paraplegia and tetraplegia
+∞
11.5
11
*
G11.4
ICD-10 Finland
Hereditary spastic paraplegia
+∞
11.5
11
*
G99.2*M47.0
ICD-10 Finland
Anterior spinal and vertebral artery compression syndromes
121.8
11.5
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
11.4
161
897
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
11.4
118
575
J96.1
ICD-10 Finland
Chronic respiratory failure
5.4
11.3
33
63
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.1
11.2
63
216
N05AA02
ATC
levomepromazine; systemic
3.7
11.2
48
135
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
13.0
11.2
19
15
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.2
257
1701
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.5
11.1
32
60
R35
ICD-10 Finland
Polyuria
3.1
11.1
60
202
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
4.7
11.1
37
82
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
11.1
76
298
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
4.1
11.1
42
106
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
6.8
11.1
27
41
N03AF01
ATC
carbamazepine; oral, rectal
3.4
11.0
54
169
R50.9
ICD-10 Finland
Fever, unspecified
2.2
11.0
120
600
SPAT1263
SPAT
Sampling
1.7
10.9
309
2175
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
10.9
310
2186
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
12.2
10.9
19
16
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.0
10.9
62
216
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
15.8
10.9
17
11
XA402
NOMESCO Finland
ENMG
5.3
10.9
32
62
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.5
10.8
50
150
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
21.8
10.7
15
7
M03BX02
ATC
tizanidine; oral
1.7
10.7
424
3285
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.1
10.7
60
206
ABC63
NOMESCO Finland
Decompression of thoracic spinal cord
60.9
10.6
12
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
8.7
10.6
22
26
U71
ICPC
Cystitis/urinary infection other
3.1
10.6
57
192
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.8
10.6
44
121
F43.29
ICD-10 Finland
Adaptation disorder UNS
7.5
10.5
24
33
NF3AA
NOMESCO Finland
Femur X-ray examination
6.0
10.5
28
48
N02BE01
ATC
paracetamol; systemic, rectal
1.9
10.5
606
5250
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
111.5
10.4
11
*
G83.1
ICD-10 Finland
Monoplegia of lower limb
111.5
10.4
11
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
10.4
10
*
80691
ICD-8 Finland
Fracture and fracture dislocation of vertebral column with spinal cord lesion, Thoracica, Sequelae
+∞
10.4
10
*
C72.00
ICD-10 Finland
Malignant tumor of the spinal cord without histology
+∞
10.4
10
*
A08
ICPC
Swelling
3.7
10.4
44
123
QBG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of trunk
33.0
10.4
13
*
204
Kela drug reimbursment
Leukemia lymphatica
5.0
10.3
32
66
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
19.1
10.3
15
8
JN4BD
NOMESCO Finland
Extensive body CT
2.4
10.3
92
418
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.1
10.2
39
100
TQW11
NOMESCO Finland
Vacuum treatment of wound
5.3
10.1
30
59
SPAT1301
SPAT
No procedures
1.8
10.1
230
1509
S82.1
ICD-10 Finland
Fracture of upper end of tibia
6.4
9.9
25
40
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
8.9
9.8
20
23
S22.1
ICD-10 Finland
Multiple fractures of thoracic spine
20.3
9.8
14
7
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
10.8
9.8
18
17
Z50.1
ICD-10 Finland
Other physical therapy
3.2
9.8
51
168
N30.2
ICD-10 Finland
Other chronic cystitis
13.6
9.7
16
12
NF1AA
NOMESCO Finland
Hip X-ray examination
2.6
9.7
71
290
N30
ICD-10 Finland
Cystitis
2.9
9.6
57
205
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
9.6
54
185
R32
ICD-10 Finland
Unspecified urinary incontinence
4.8
9.6
31
67
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.4
9.6
45
137
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
7.3
9.6
22
31
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.8
9.5
61
231
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
5.7
9.4
26
47
NA2DG
NOMESCO Finland
Thoracal spine very extensive MRI examination with high intensity magnet
30.4
9.4
12
*
RK112
NOMESCO Finland
NA
+∞
9.4
9
*
S24.1
ICD-10 Finland
Other and unspecified injuries of thoracic spinal cord
+∞
9.4
9
*
G83.8
ICD-10 Finland
Other specified paralytic syndromes
+∞
9.4
9
*
A211_
NOMESCO Finland
NA
+∞
9.4
9
*
R51.80
ICD-10 Finland
Headache
2.1
9.4
110
564
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.3
9.4
84
383
R06.0
ICD-10 Finland
Dyspnoea
1.8
9.3
179
1108
G04AA01
ATC
NA
9.7
9.3
18
19
N39.9
ICD-10 Finland
Disorder of urinary system, unspecified
6.2
9.3
24
40
G04BE03
ATC
sildenafil; oral
6.2
9.3
24
40
R13
ICD-10 Finland
Dysphagia
2.9
9.3
57
208
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.2
123
667
Z04.3
ICD-10 Finland
Examination and observation following other accident
5.1
9.2
28
57
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.1
9.2
28
57
B01AA03
ATC
warfarin; systemic
1.9
9.2
154
909
N06AX11
ATC
mirtazapine; oral
1.7
9.2
217
1434
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
9.1
81
365
SPAT1234
SPAT
Support of social functional capacity
3.0
9.0
51
176
NA3CM
NOMESCO Finland
Lumbar spine extensive MRI examination with 3 Tesla magnet
24.3
8.9
12
5
G99.2*M51.0
ICD-10 Finland
Lumbar and other intervertebral disc disorders with myelopathy
24.3
8.9
12
5
QBA10
NOMESCO Finland
Incision of skin of trunk
9.6
8.8
17
18
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.7
8.8
60
236
J01CF05
ATC
flucloxacillin; systemic
3.7
8.8
37
104
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.3
8.8
84
393
WX725
NOMESCO Finland
Noninvasive ventilation
3.2
8.7
45
148
RS142
NOMESCO Finland
NA
50.6
8.7
10
*
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.2
8.7
44
143
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
5.9
8.6
23
40
WX892
NOMESCO Finland
Monitored bed care
2.5
8.6
68
290
M79.6
ICD-10 Finland
Pain in limb
1.7
8.6
241
1667
L03AB07
ATC
interferon beta-1a; parenteral
10.2
8.6
16
16
M54.5
ICD-10 Finland
Low back pain
1.7
8.5
226
1539
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
27.9
8.5
11
*
KH1AT
NOMESCO Finland
Urinary tract cathetrisation with ultrasound guidance
27.9
8.5
11
*
S76
ICPC
Skin infection other
3.1
8.5
45
151
6BA02
NOMESCO Finland
NA
20.3
8.5
12
6
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.3
8.5
30
72
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.7
8.4
35
97
ZZA00
NOMESCO Finland
Split skin graft
4.0
8.4
32
82
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
4.6
8.4
28
63
RJ630
NOMESCO Finland
NA
91.1
8.4
9
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
+∞
8.3
8
*
AEA30
NOMESCO Finland
Replacement of implanted pump of injection device in the nervous system
+∞
8.3
8
*
Q82.2
ICD-10 Finland
Mastocytosis
+∞
8.3
8
*
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
8.3
8
*
XA800
NOMESCO Finland
Neuropsychological investigation
3.3
8.3
40
125
UJF32
NOMESCO Finland
Coloscopy
1.7
8.3
178
1135
S12.2
ICD-10 Finland
Fracture of other specified cervical vertebra
10.9
8.3
15
14
N03AX09
ATC
lamotrigine; oral
3.2
8.3
43
142
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.6
8.3
60
244
RS222
NOMESCO Finland
NA
7.2
8.3
19
27
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.6
8.3
36
104
N05AH04
ATC
quetiapine; oral
2.0
8.3
116
640
A04
ICPC
Weakness/tiredness general
2.1
8.2
98
508
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.1
8.2
100
523
KCE02
NOMESCO Finland
Transluminal endoscopic extraction of calculus from bladder
8.3
8.1
17
21
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
8.3
8.1
17
21
ABC53
NOMESCO Finland
Decompression of thoracic spinal canal and nerve roots
33.7
8.1
10
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.1
8.1
43
145
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
10.2
8.1
15
15
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
8.0
89
447
N05BA04
ATC
oxazepam; oral
1.7
8.0
171
1086
A82
ICPC
Secondary effect of trauma
22.3
8.0
11
5
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
8.0
86
423
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
8.0
54
209
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.0
8.0
45
156
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
7.9
7.9
17
22
R11
ICD-10 Finland
Nausea and vomiting
2.5
7.9
63
269
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.7
7.8
53
207
R52.1
ICD-10 Finland
Chronic intractable pain
9.5
7.8
15
16
X58
ICD-10 Finland
Exposure to other specified factors
2.0
7.8
105
571
A01
ICPC
Pain general/multiple sites
2.4
7.8
63
273
WX882
NOMESCO Finland
High dependency care
3.6
7.8
33
94
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
4.2
7.8
28
69
L81
ICPC
Injury musculoskeletal NOS
4.7
7.7
25
55
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
4.7
7.7
25
55
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.0
7.7
29
74
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
7.7
147
901
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
15.2
7.7
12
8
RS314
NOMESCO Finland
NA
45.5
7.7
9
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
45.5
7.7
9
*
G95.2
ICD-10 Finland
Cord compression, unspecified
45.5
7.7
9
*
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
6.0
7.7
20
34
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.1
7.7
40
133
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
7.7
163
1033
NG4AA
NOMESCO Finland
Lower leg X-ray examination
4.1
7.6
28
70
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
18.6
7.6
11
6
KDV20
NOMESCO Finland
Submucous urethral injection
25.3
7.6
10
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.2
7.6
27
66
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.9
7.5
29
76
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
3.4
7.5
34
102
L17
ICPC
Foot/toe symptom/complaint
1.7
7.5
169
1091
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
7.4
71
333
1601
FHL
Cystometry
80.9
7.4
8
*
G83.9
ICD-10 Finland
Paralytic syndrome, unspecified
80.9
7.4
8
*
B91
ICD-10 Finland
Sequelae of poliomyelitis
80.9
7.4
8
*
SPAT1211
SPAT
Application of soft bandage
2.3
7.4
68
312
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.7
7.4
49
191
R39.1
ICD-10 Finland
Other difficulties with micturition
3.6
7.4
31
88
D17
ICPC
Incontinence of bowel
8.5
7.3
15
18
A02BC01
ATC
omeprazole; systemic
1.7
7.3
185
1233
Z02.7
ICD-10 Finland
Issue of medical certificate
2.6
7.3
51
204
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
9.5
7.3
14
15
G83.3
ICD-10 Finland
Monoplegia, unspecified
+∞
7.3
7
*
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
+∞
7.3
7
*
3430A
ICD-9 Finland
Infantile cerebral palsy, Diplegic
+∞
7.3
7
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
7.3
127
754
G04BD09
ATC
trospium; oral
4.3
7.3
25
59
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.4
7.3
62
275
R5599
NOMESCO Finland
Other rehabilitation service
3.8
7.2
29
79
N30.1
ICD-10 Finland
Interstitial cystitis (chronic)
7.4
7.2
16
22
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
30.3
7.2
9
*
RF310
NOMESCO Finland
NA
30.3
7.2
9
*
M86.4
ICD-10 Finland
Chronic osteomyelitis with draining sinus
30.3
7.2
9
*
M41.5
ICD-10 Finland
Other secondary scoliosis
30.3
7.2
9
*
RK220
NOMESCO Finland
NA
20.2
7.1
10
5
KCW98
NOMESCO Finland
Other transluminal endoscopic operation on bladder
20.2
7.1
10
5
ABD99
NOMESCO Finland
Other operation on spinal cord or nerve for pain or impaired function
20.2
7.1
10
5
RS122
NOMESCO Finland
NA
20.2
7.1
10
5
Z73.6
ICD-10 Finland
Limitation of activities due to disability
6.7
7.1
17
26
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.0
7.1
39
135
ZX120
NOMESCO Finland
Intravenous
2.1
7.1
80
403
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.1
7.1
18
30
G99.2*M50.0
ICD-10 Finland
Cervical disc disorder with myelopathy
12.2
7.1
12
10
V29.9
ICD-10 Finland
Motorcycle rider [any] injured in unspecified traffic accident
7.1
7.0
16
23
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
6.9
60
269
A03
ICPC
Fever
1.9
6.9
109
628
NFQ20
NOMESCO Finland
Amputation of femur
8.4
6.8
14
17
L03AX13
ATC
glatiramer acetate; parenteral
11.1
6.8
12
11
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.0
6.8
37
128
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
6.8
123
739
GBB00
NOMESCO Finland
Tracheostomy
5.7
6.8
18
32
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.2
6.8
64
299
N05CD07
ATC
temazepam; oral
1.9
6.8
92
503
ABB20
NOMESCO Finland
Drainage of intra- or extramedullary cyst of spinal canal
40.4
6.8
8
*
Z93.5
ICD-10 Finland
Cystostomy status
40.4
6.8
8
*
N07BC02
ATC
methadone; systemic
16.9
6.8
10
6
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
16.9
6.8
10
6
J01CE08
ATC
benzathine benzylpenicillin; parenteral
7.3
6.7
15
21
J01DA01
ATC
[U] cefalexin; systemic
1.5
6.7
420
3458
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
5.0
6.7
20
41
F61.0
ICD-10 Finland
Mixed personality disorders
6.5
6.7
16
25
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
6.7
125
760
U28
ICPC
Limited function/disability (U)
6.0
6.6
17
29
SPAT1127
SPAT
Enema
7.9
6.6
14
18
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
7.9
6.6
14
18
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.7
6.6
21
46
WX702
NOMESCO Finland
Supraglottic ventilation device
2.7
6.6
43
166
A29
ICPC
General symptom/complaint other
2.0
6.6
81
426
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.2
6.6
33
108
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
10.1
6.5
12
12
Z75.5
ICD-10 Finland
Holiday relief care
10.1
6.5
12
12
ZZR00
NOMESCO Finland
Flap of skin
4.2
6.5
23
56
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
6.9
6.5
15
22
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
4.0
6.5
24
61
UJH02
NOMESCO Finland
Anoscopy
3.0
6.5
37
129
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.3
6.5
57
255
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
3.1
6.5
33
109
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
6.3
6.5
16
26
Z71.8
ICD-10 Finland
Other specified counselling
1.7
6.5
157
1032
G83.2
ICD-10 Finland
Monoplegia of upper limb
70.4
6.4
7
*
NAW10
NOMESCO Finland
Reoperation for superficial infection in in surgery of spine or neck
70.4
6.4
7
*
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
70.4
6.4
7
*
9222
FHL
Surgery for a fresh back injury
70.4
6.4
7
*
NA7FT
NOMESCO Finland
Labeling lesion in spinal area with X-ray guidance
70.4
6.4
7
*
Z99.8
ICD-10 Finland
Dependence on other enabling machines and devices
70.4
6.4
7
*
SPAT1125
SPAT
Stoma care and guidance
4.5
6.4
21
48
RK110
NOMESCO Finland
NA
8.2
6.3
13
16
S29
ICPC
Skin symptom/complaint other
1.8
6.3
113
678
XG466
NOMESCO Finland
Sleep oxymetry
3.2
6.3
31
100
M05BX04
ATC
denosumab; parenteral
2.9
6.3
37
134
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.1
6.3
72
365
N30.8
ICD-10 Finland
Other cystitis
11.1
6.3
11
10
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
11.1
6.3
11
10
S72.2
ICD-10 Finland
Subtrochanteric fracture
11.1
6.3
11
10
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.4
6.3
53
233
ZXF05
NOMESCO Finland
Interruption of procedure for other patient related reason
9.4
6.3
12
13
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
9.4
6.3
12
13
NAG41
NOMESCO Finland
Anterior fusion of cervical spine with fixation
9.4
6.3
12
13
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
6.3
6
*
5965X
ICD-9 Finland
Other disorders of bladder, Other functional disorders of bladder[ALIA FUNCTIO LAESA VESICAE URINARIAE]
+∞
6.3
6
*
C41.29
ICD-10 Finland
Malignant tumor of the spine other or unspecified histology
+∞
6.3
6
*
D33.43
ICD-10 Finland
Spinal cord
+∞
6.3
6
*
D33.41
ICD-10 Finland
Myxopapillary epndymoma of the spinal cord (grade I)
+∞
6.3
6
*
9530/0-C70.1
ICD-O-3
Meningioma, NOS, of spinal meninges
+∞
6.3
6
*
C41.20
ICD-10 Finland
Malignant tumor of the spine without histology
+∞
6.3
6
*
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
+∞
6.3
6
*
T09.3
ICD-10 Finland
Injury of spinal cord, level unspecified
+∞
6.3
6
*
T91.8
ICD-10 Finland
Sequelae of other specified injuries of neck and trunk
26.9
6.2
8
*
RF120
NOMESCO Finland
NA
6.4
6.2
15
24
WF049
NOMESCO Finland
Radiotherapy of metastasis
3.1
6.2
31
102
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
6.2
221
1603
L03AB08
ATC
interferon beta-1b; parenteral
12.6
6.1
10
8
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
12.6
6.1
10
8
M47.9
ICD-10 Finland
Spondylosis, unspecified
3.2
6.1
29
92
S70.0
ICD-10 Finland
Contusion of hip
3.1
6.0
31
104
WX730
NOMESCO Finland
Conventional respirator
6.1
6.0
15
25
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
6.0
32
110
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
6.0
57
269
L29
ICPC
Musculoskeletal sympt/complt other
2.2
6.0
57
269

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
121
8.05
61.74
1.8
1.4
—
—
—
0
0
392
1800
3.30
60.25
7.5
2.9
—
—
—
0
0
93
149
6.93
56.79
1.6
1.4
902.8
455.0
mg/l
2.76
84
139
57
51
11.96
54.97
1.9
1.5
—
—
—
0
0
366
1778
2.95
48.38
7.8
4.3
—
—
—
0
0
81
134
6.61
47.81
1.6
1.4
3.8
3.8
mmol/l
0.07
75
124
74
130
6.17
41.05
1.8
1.4
35.7
11.7
e6/l
0.60
54
102
74
130
6.17
41.05
1.8
1.5
456.1
1459.5
e6/l
0.49
54
106
49
56
9.25
39.65
2.0
1.6
—
—
—
0
0
193
762
3.02
35.66
3.8
1.7
—
—
—
0
0
228
1019
2.73
33.15
4.0
3.4
0.8
0.8
mmol/l
0.77
207
947
345
1914
2.41
31.44
2.7
2.1
217.1
304.4
u/l
0.75
328
1802
433
2696
2.32
29.68
6.1
4.8
33.2
35.5
g/l
10.40
404
2505
444
2841
2.26
27.89
9.2
5.9
1.2
1.2
mmol/l
2.16
414
2562
81
213
4.12
27.88
2.2
2.5
221.3
500.7
ug/l
0.74
74
202
469
3100
2.24
26.79
9.7
6.7
1.2
1.2
mmol/l
1.60
409
2606
246
1245
2.41
26.78
5.4
2.9
528.5
566.2
mosm/kgh2o
2.30
222
1060
255
1313
2.38
26.68
5.1
2.6
4.4
5.4
e6/l
0.67
233
1156
355
2104
2.23
26.54
8.5
5.7
—
—
—
0
0
186
832
2.61
26.34
6.2
5.5
1.1
1.0
mmol/l
0.93
168
766
201
936
2.53
26.16
3.4
2.1
—
—
—
0
0
568
4130
2.29
24.71
11.0
4.2
4148.8
1812.1
e6/l
0.38
14
69
445
2956
2.14
24.14
9.8
6.1
8.4
8.8
%
1.73
419
2769
325
1916
2.17
24.04
7.3
3.2
45.5
95.7
e6/l
0.71
271
1482
442
2940
2.12
23.75
9.4
5.8
2.8
2.9
%
0.24
416
2735
431
2855
2.10
23.23
9.3
5.8
0.7
0.7
%
0.14
402
2666
448
3023
2.09
22.83
9.5
6.0
25.6
27.7
%
3.36
420
2816
581
4349
2.22
22.25
8.7
4.2
—
—
—
0
0
298
1740
2.13
22.21
6.9
3.1
0.4
0.4
e6/l
0.32
246
1308
357
2231
2.08
22.21
8.6
3.7
127.7
128.6
e6/l
0.01
281
1586
115
445
2.85
21.35
7.4
3.8
5.5
5.2
kpa
2.46
108
416
331
2041
2.06
21.07
4.0
2.4
—
—
—
0
0
437
2977
2.03
21.06
9.1
5.7
59.6
57.3
%
3.47
412
2793
113
440
2.83
20.71
7.5
3.8
7.4
7.4
ph
0.31
13
49
285
1687
2.07
20.07
7.1
3.1
—
—
—
0
0
91
320
3.08
20.01
5.7
4.1
—
—
—
0
0
43
89
5.05
19.87
9.6
5.9
11.7
11.2
mg/l
0.28
38
84
139
614
2.53
19.79
2.6
2.2
0.2
0.2
g/l
2.44
126
571
27
35
7.95
19.65
1.3
1.1
—
—
—
0
0
155
723
2.42
19.60
8.9
7.8
1.6
1.1
mmol/l
0.65
123
562
155
728
2.40
19.28
8.8
7.7
5.3
5.1
kpa
1.29
140
698
155
729
2.40
19.22
8.7
7.7
12.1
12.1
kpa
0.06
140
702
389
2603
1.96
19.10
11.6
9.2
1.3
1.2
inr
0.91
110
738
192
993
2.23
19.04
2.7
2.2
30.2
29.7
s
0.49
186
960
447
3142
1.95
18.90
8.8
5.7
0.0
0.0
e9/l
0.56
394
2722
445
3129
1.95
18.73
8.7
5.7
0.6
0.6
e9/l
0.08
393
2698
102
401
2.77
18.28
1.7
2.5
—
—
—
0
0
262
1548
2.03
18.22
3.7
2.3
—
—
—
0
0
508
3755
1.96
18.21
8.1
4.7
6.7
6.7
mmol/l
0.14
483
3515
456
3255
1.93
18.11
9.0
5.9
0.2
0.2
e9/l
0.28
405
2865
376
2521
1.93
18.03
2.9
2.2
77.3
76.1
nmol/l
0.31
338
2251
116
492
2.59
17.88
1.9
2.7
65.7
66.9
g/l
0.74
105
449
265
1585
2.00
17.72
7.5
3.9
86.9
89.6
%
0.93
257
1551
448
3208
1.90
17.31
9.0
5.7
1.8
1.9
e9/l
1.24
395
2826
113
484
2.55
17.04
2.4
2.4
10.1
10.7
g/l
0.62
104
442
123
559
2.42
16.31
9.1
7.2
1.4
1.4
mmol/l
0.18
115
532
454
3315
1.85
15.98
7.6
6.4
10.5
11.4
umol/l
0.47
442
3150
136
652
2.31
15.96
9.6
8.2
95.1
95.5
%
0.28
125
630
262
1610
1.93
15.88
2.8
2.1
3.2
3.0
mg/l
0.53
221
1374
426
3056
1.84
15.82
6.5
3.5
0.0
0.0
estimate
0.00
91
568
74
267
2.95
15.49
3.0
2.1
3.6
2.6
ug/l
0.12
63
238
142
702
2.24
15.46
2.7
2.5
1.8
1.8
%
0.22
125
634
191
1065
2.04
15.22
5.4
2.7
1.3
1.0
e6/l
0.35
127
615
184
1013
2.06
15.18
6.2
2.9
2.3
2.2
e6/l
0.05
120
564
484
3642
1.83
15.07
11.8
9.0
4.4
4.1
e9/l
1.61
434
3185
124
585
2.32
15.06
6.0
3.9
6.1
5.8
kpa
1.89
119
568
422
3048
1.81
15.05
8.9
4.8
0.0
0.0
estimate
0.50
88
576
425
3087
1.80
14.77
6.7
3.5
0.0
0.0
estimate
0.50
92
546
82
324
2.71
14.49
8.8
10.5
24.7
24.5
mmol/l
0.19
75
305
40
102
4.07
14.30
1.6
1.2
57.6
64.4
mmol/l
0.49
26
87
121
583
2.27
13.94
6.1
3.9
2.1
1.8
mmol/l
0.34
105
464
77
303
2.70
13.71
7.1
4.1
24.4
24.0
mmol/l
0.42
70
282
111
521
2.31
13.59
11.4
8.8
—
—
—
0
0
363
2569
1.75
13.34
2.4
2.0
90.2
94.6
pmol/l
1.02
212
1361
200
1183
1.92
13.24
1.9
1.7
1038.3
1186.4
nmol/l
1.51
150
894
109
514
2.30
13.19
2.6
2.7
69.7
69.2
e9/l
0.06
83
402
120
594
2.20
12.91
10.0
8.7
120.4
121.8
g/l
0.27
112
574
306
2085
1.76
12.68
3.0
3.3
2.3
2.4
mmol/l
1.66
261
1828
69
268
2.72
12.59
2.2
1.7
—
—
—
0
0
592
4866
1.83
12.44
10.9
7.6
85.3
78.6
u/l
2.56
568
4563
403
2982
1.71
12.28
6.0
4.0
—
—
—
0
0
113
558
2.19
12.20
6.5
7.5
10.3
9.9
mmol/l
0.19
108
532
92
420
2.34
11.97
6.9
4.8
—
—
—
0
0
274
1843
1.74
11.68
5.0
3.8
7.4
7.4
ph
0.72
58
339
145
809
1.97
11.25
11.1
6.9
103.3
104.2
mmol/l
1.23
139
790
93
452
2.20
10.41
3.7
3.9
68.4
84.9
ng/l
1.18
85
400
219
1423
1.74
10.35
5.4
3.4
—
—
—
0
0
15
8
19.07
10.29
1.2
1.0
13.0
6.7
mg/g
—
15
8
235
1560
1.72
10.27
10.4
6.5
—
—
—
0
0
143
820
1.91
10.17
1.4
1.3
416.0
468.4
titre
0.20
30
176
150
875
1.88
10.12
2.8
2.4
17.4
23.3
%
6.18
129
755
156
922
1.86
10.10
2.8
2.3
2.3
2.3
g/l
0.49
143
866
15
9
16.96
9.90
1.3
1.0
—
—
—
0
0
49
183
2.79
9.65
1.8
2.7
35.4
38.0
g/l
1.68
40
158
37
118
3.24
9.57
4.6
2.3
—
—
—
0
0
11
11
10.13
9.56
1.1
1.0
—
—
—
0
0
48
179
2.79
9.48
9.9
2.5
26.1
24.7
mmol/l
1.31
42
157
33
99
3.43
9.40
3.8
3.4
2.0
1.3
%
0.32
22
82
22
49
4.59
9.35
3.1
1.8
45.7
34.1
%
—
6
7
139
814
1.86
9.21
24.7
23.1
1.5
1.3
inr
0.53
16
106
26
67
3.98
9.20
1.3
1.4
277.9
279.8
mosm/kgh2o
0.12
18
48
23
54
4.36
9.17
4.0
2.0
1.2
1.1
e9/l
0.18
12
26
179
1136
1.74
9.06
2.7
3.0
2.5
2.4
mmol/l
1.03
151
999
277
1974
1.62
8.99
2.9
2.6
49.9
56.4
u/l
3.44
259
1840
19
39
4.97
8.87
3.2
1.9
13.3
12.2
%
—
9
19
356
2698
1.57
8.87
3.4
2.7
167.2
141.4
ug/l
0.59
323
2485
37
125
3.05
8.72
3.1
2.2
15.8
16.5
%
0.48
21
63
95
500
2.02
8.62
6.5
3.2
5.0
4.6
kpa
0.76
90
484
161
1005
1.75
8.60
2.9
2.3
10.2
13.2
umol/l
3.84
145
937
79
394
2.11
8.27
3.8
2.6
—
—
—
0
0
103
568
1.93
8.17
2.1
2.0
312.0
382.6
nmol/l
3.24
92
517
78
393
2.09
7.96
1.9
1.6
1.1
1.5
g/l
1.64
73
364
217
1495
1.62
7.92
1.8
1.6
20.8
20.7
nmol/l
0.03
189
1261
60
273
2.29
7.87
1.8
1.8
1.8
1.5
g/l
1.29
51
239
79
402
2.07
7.85
11.7
7.0
26.0
24.3
mmol/l
2.70
69
376
95
517
1.95
7.83
4.1
4.2
1.3
0.9
%
0.56
34
171
325
2473
1.53
7.62
5.1
3.6
212.2
54.6
ng/l
0.48
263
1732
36
130
2.85
7.58
1.4
1.7
—
—
—
0
0
37
136
2.80
7.54
4.0
3.1
—
—
—
0
0
23
63
3.73
7.50
3.8
3.5
62.2
53.1
%
0.76
13
46
87
468
1.96
7.42
4.0
4.1
1.4
0.4
%
0.88
23
127
68
337
2.11
7.25
11.5
11.0
—
—
—
0
0
105
609
1.83
7.12
6.0
4.1
—
—
—
0
0
15
31
4.91
6.95
1.1
1.3
135.0
148.2
nmol/l
0.40
15
31
88
487
1.91
6.90
4.1
4.3
0.2
0.1
%
0.10
30
155
250
1847
1.51
6.52
3.5
3.1
1048.0
1383.7
ng/l
1.10
223
1573
120
747
1.71
6.38
3.0
2.6
8.4
7.9
umol/l
0.07
102
657
17
42
4.11
6.38
1.3
1.3
5.5
6.5
u/l
0.34
11
32
41
174
2.43
6.32
2.1
3.8
739.0
93.7
mg/l
0.45
36
144
82
457
1.88
6.30
4.0
4.4
0.0
0.1
%
0.83
24
135
179
1237
1.58
6.29
1.6
1.4
2.3
2.5
g/l
0.54
114
761
13
26
5.07
6.24
1.8
3.0
606.5
581.2
u/ml
0.06
13
26
162
2287
0.63
6.18
3.0
2.8
—
—
—
0
0
79
439
1.89
6.12
4.9
2.8
4.5
4.0
e9/l
0.83
53
343
122
773
1.68
6.07
1.9
1.4
—
—
—
0
0
34
135
2.59
6.02
2.8
2.1
—
—
—
0
0
18
49
3.73
5.95
2.1
1.3
—
—
—
0
0
40
174
2.37
5.85
2.2
3.8
42.5
52.3
mg/l
0.23
35
145
224
1657
1.49
5.69
7.3
3.8
0.0
0.0
estimate
1.08
89
556
39
171
2.35
5.62
2.2
3.7
0.9
2.0
ratio
—
6
19
20
62
3.28
5.48
1.1
1.2
—
—
—
0
0
539
4707
1.44
5.47
5.1
4.0
16.0
11.9
mm/h
5.75
501
4327
39
174
2.30
5.41
4.2
3.7
1.6
1.6
mg/l
0.21
32
159
47
227
2.14
5.39
3.6
2.4
21.3
21.7
s
0.15
41
203
23
79
2.97
5.34
4.6
3.9
—
—
—
0
0
193
1404
1.49
5.27
2.4
1.8
1.4
1.2
mg/l
0.61
155
1075
11
22
5.06
5.27
1.4
1.2
—
—
—
0
0
86
515
1.75
5.24
2.9
2.9
180.1
203.0
ng/l
0.20
76
474
20
64
3.18
5.22
1.8
1.5
—
—
—
0
0
8
6
13.45
5.08
1.0
1.0
—
—
—
0
0
17
50
3.45
5.05
4.1
1.9
628.5
714.8
e6/l
—
8
20
11
23
4.84
5.02
3.0
1.9
94.2
86.2
ug/l
0.07
11
23
183
1332
1.48
4.96
1.6
1.7
33553077.4
9736545.3
pmol/l
0.31
152
1099
342
2791
1.39
4.94
15.1
9.0
0.0
0.0
e9/l
0.41
284
2277
58
313
1.92
4.94
3.9
3.8
—
—
—
0
0
187
1377
1.47
4.76
7.4
3.7
1.0
1.0
kg/l
1.66
36
183
26
104
2.55
4.58
1.5
1.7
—
—
—
0
0
31
136
2.33
4.50
3.4
2.0
123.3
131.7
g/l
1.06
25
101
26
105
2.53
4.50
1.5
1.2
—
—
—
0
0
29
124
2.39
4.46
1.8
4.0
—
—
—
0
0
219
1685
1.41
4.36
6.9
3.2
—
—
—
0
0
30
132
2.32
4.34
3.1
3.5
3.2
2.4
mmol/l
0.47
24
87
76
466
1.70
4.28
1.2
1.2
—
—
—
0
0
574
6239
0.72
4.13
4.5
4.3
1.4
1.4
mmol/l
2.43
516
5724
39
196
2.04
4.09
7.5
7.1
1.7
1.3
mmol/l
0.71
28
170
13
37
3.55
4.06
5.3
2.4
—
—
—
0
0
21
82
2.60
3.91
1.8
2.2
31.8
33.5
pg
0.74
21
82
232
1836
1.37
3.84
4.8
3.8
—
—
—
0
0
107
734
1.53
3.82
1.8
1.6
—
—
—
0
0
594
6398
0.72
3.77
4.9
4.8
2.7
2.7
mmol/l
1.41
535
5869
48
269
1.83
3.70
6.5
5.6
2.4
1.6
%
1.91
41
254
84
550
1.59
3.68
3.6
2.3
6.4
8.0
ug/l
0.48
69
484
9
16
5.68
3.66
1.7
1.1
—
—
—
0
0
81
528
1.59
3.62
1.3
1.4
—
—
—
0
0
582
6276
0.74
3.57
4.6
4.3
4.5
4.6
mmol/l
2.35
526
5792
25
112
2.27
3.51
1.3
1.3
99.6
102.8
u/ml
—
7
25
9
18
5.04
3.37
3.4
1.6
—
—
—
0
0
141
1049
1.42
3.34
1.4
1.3
30.8
31.7
iu/ml
0.03
46
334
17
65
2.65
3.32
1.0
1.1
—
—
—
0
0
119
859
1.45
3.32
1.3
1.2
—
—
—
0
0
18
71
2.57
3.31
1.2
1.3
—
—
—
0
0
29
143
2.07
3.24
11.1
3.0
—
—
—
0
0
35
185
1.93
3.24
6.7
2.9
—
—
—
0
0
33
171
1.97
3.23
1.5
1.5
10.1
8.9
u/l
0.19
28
138
21
91
2.34
3.19
2.3
3.0
—
—
—
0
0
17
67
2.57
3.14
1.2
1.2
—
—
—
0
0
26
125
2.12
3.11
1.3
1.3
—
—
—
0
0
11
34
3.27
3.06
4.2
5.0
7.4
7.4
ph
—
6
7
11
34
3.27
3.06
1.2
1.1
—
—
—
0
0
29
148
2.00
2.98
8.5
7.6
103.7
105.5
mmol/l
1.16
22
135
29
148
2.00
2.98
8.5
7.6
12.5
11.4
mmol/l
0.51
22
135
68
448
1.57
2.94
1.5
1.5
—
—
—
0
0
561
6033
0.77
2.92
4.2
3.9
1.3
1.3
mmol/l
0.82
499
5512
73
490
1.54
2.91
4.1
3.4
1.2
1.2
mmol/l
1.01
66
425
157
1218
1.36
2.89
4.8
3.8
448.0
378.5
ng/l
0.10
118
954
9
22
4.13
2.88
5.0
2.6
—
—
—
0
0
16
64
2.53
2.88
1.3
1.3
—
—
—
0
0
71
476
1.54
2.85
1.5
1.5
—
—
—
0
0
17
71
2.42
2.81
1.2
1.3
0.5
0.6
nmol/l
0.20
17
63
45
270
1.71
2.81
7.0
5.6
0.8
0.9
%
1.09
38
255
17
366
0.45
2.78
1.2
1.4
—
—
—
0
0
144
1109
1.36
2.77
2.0
1.8
—
—
—
0
0
35
196
1.82
2.76
1.5
1.2
—
—
—
0
0
5
6
8.38
2.75
1.4
1.2
—
—
—
0
0
37
619
0.58
2.75
1.2
1.4
—
—
—
0
0
237
1964
1.29
2.74
4.4
3.1
6.2
7.8
mmol/l
7.19
191
1621
172
1367
1.33
2.69
1.3
1.3
1.4
2.3
u/ml
0.65
37
367
8
19
4.24
2.68
1.4
1.2
—
—
—
0
0
8
19
4.24
2.68
1.1
1.1
1381.9
1745.3
miu/ml
—
8
19
202
1652
1.30
2.56
3.1
2.6
1439.8
7090.3
umol/l
2.97
172
1426
120
909
1.38
2.56
1.8
1.6
—
—
—
0
0
76
530
1.48
2.55
7.3
3.7
—
—
—
0
0
31
172
1.83
2.53
1.5
1.2
—
—
—
0
0
675
6396
1.35
2.49
34.7
14.1
28.1
24.5
mg/l
2.10
601
5053
689
6550
1.37
2.48
35.4
16.4
4.0
4.0
mmol/l
0.45
676
6359
22
110
2.03
2.43
1.1
1.1
—
—
—
0
0
10
34
2.97
2.42
2.7
3.6
—
—
—
0
0
687
6534
1.36
2.41
35.5
16.3
139.0
139.7
mmol/l
7.83
675
6354
129
999
1.35
2.40
1.3
1.3
25.1
12.2
u/ml
0.57
40
382
15
64
2.37
2.40
1.3
1.3
—
—
nmol/l
—
0
0
21
104
2.05
2.38
1.1
1.1
—
—
—
0
0
21
104
2.05
2.38
1.5
1.5
—
—
—
0
0
5
8
6.28
2.37
1.2
1.4
—
—
—
0
0
36
216
1.70
2.29
2.8
3.4
0.3
0.3
g/l
0.17
14
94
13
53
2.48
2.28
1.3
2.3
11.0
10.4
%
0.17
13
53
513
4718
1.24
2.27
4.1
3.8
15.1
14.8
pmol/l
2.00
463
4265
7
18
3.91
2.25
3.6
1.3
—
—
—
0
0
22
115
1.94
2.17
12.8
2.4
—
—
—
0
0
23
123
1.90
2.13
1.4
1.2
324.7
259.8
u/ml
0.40
15
68
38
238
1.63
2.08
9.6
4.1
—
—
—
0
0
32
192
1.69
2.06
9.5
3.5
4.0
3.9
mmol/l
0.18
26
177
280
2437
1.23
2.04
2.2
2.1
—
—
—
0
0
8
28
2.88
1.86
2.1
1.9
—
—
—
0
0
10
40
2.52
1.84
13.4
2.6
—
—
—
0
0
8
29
2.78
1.79
1.6
1.1
390.1
138.6
iu/ml
—
8
29
13
60
2.19
1.78
11.3
2.8
—
—
—
0
0
17
88
1.95
1.76
2.5
2.5
—
—
—
0
0
6
18
3.35
1.75
1.2
1.0
—
—
—
0
0
6
18
3.35
1.75
2.5
1.2
-0.1
2.9
mmol/l
—
6
18
20
110
1.84
1.74
1.3
1.4
—
—
—
0
0
13
61
2.15
1.72
1.0
1.2
—
—
—
0
0
5
13
3.86
1.71
1.4
1.5
—
—
—
0
0
71
530
1.37
1.71
4.7
3.1
—
—
—
0
0
222
1923
1.21
1.65
4.0
4.0
13.8
9.3
mg/mmol
0.79
145
1217
7
26
2.71
1.58
1.3
1.5
—
—
—
0
0
11
50
2.22
1.57
1.1
1.1
—
—
—
0
0
24
145
1.68
1.55
1.4
1.6
6908.3
12640.7
e6/l
0.64
18
107
34
225
1.53
1.54
1.2
1.4
28.5
27.7
iu/l
0.05
28
187
8
33
2.44
1.54
1.1
1.0
—
—
—
0
0
15
270
0.55
1.53
1.1
1.1
—
—
—
0
0
52
377
1.41
1.50
1.4
1.3
215.4
161.7
u/ml
0.25
46
343
14
72
1.96
1.49
1.8
1.4
—
—
—
0
0
7
28
2.51
1.45
1.3
1.6
—
—
—
0
0
208
1812
1.20
1.45
3.3
3.2
75.8
306.4
mg/l
1.79
139
1163
26
164
1.60
1.45
3.5
2.1
1152.2
1476.8
u/l
0.17
12
63
12
59
2.05
1.44
2.9
1.8
—
—
—
0
0
5
16
3.14
1.44
1.6
1.3
—
—
—
0
0
602
5739
1.20
1.41
5.2
4.5
1.8
2.1
mu/l
0.92
549
5210
26
167
1.58
1.36
3.7
2.9
—
—
—
0
0
16
90
1.79
1.33
1.1
1.2
—
—
—
0
0
7
150
0.46
1.32
1.1
1.7
—
—
—
0
0
5
18
2.79
1.28
2.6
2.2
—
—
—
0
0
17
99
1.73
1.28
1.6
2.6
337.0
46.7
u/ml
0.40
17
94
5
19
2.64
1.21
1.0
1.7
—
—
—
0
0
15
87
1.74
1.15
2.4
2.8
101.9
105.0
mmol/l
0.89
15
87
15
87
1.74
1.15
2.4
2.8
4.3
4.0
mmol/l
1.20
15
87
19
118
1.62
1.15
3.2
3.2
0.9
0.9
nmol/l
0.00
14
93
13
72
1.82
1.15
1.2
1.2
—
—
—
0
0
8
39
2.06
1.15
4.6
2.2
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
4.2
2.8
—
—
—
0
0
26
175
1.50
1.14
4.6
4.9
—
—
—
0
0
26
175
1.50
1.14
1.3
1.4
185.5
226.6
miu/ml
0.25
11
82
17
103
1.66
1.13
3.4
2.4
—
—
—
0
0
15
88
1.72
1.12
1.6
1.4
—
—
—
0
0
94
779
1.23
1.10
1.3
1.3
—
—
—
0
0
19
121
1.58
1.06
1.1
1.2
—
—
—
0
0
5
22
2.28
1.03
3.2
3.1
—
—
—
0
0
9
49
1.85
0.99
1.0
1.0
311.2
281.3
mg/l
—
9
42
5
23
2.18
0.98
1.0
1.3
7.4
1.3
%
—
5
16
0
31
0.00
0.96
0.0
1.3
—
—
—
0
0
64
518
1.26
0.94
1.6
1.6
—
—
—
0
0
6
27
2.23
0.93
1.2
1.8
—
—
—
0
0
13
78
1.68
0.92
1.8
1.6
—
—
—
0
0
156
1382
1.16
0.90
5.0
4.6
—
—
—
0
0
6
29
2.08
0.89
2.8
2.3
22.0
307.0
ug/l
—
6
24
26
186
1.41
0.88
1.4
1.2
—
—
—
0
0
14
87
1.62
0.88
2.5
2.8
—
—
—
0
0
15
95
1.59
0.88
1.2
1.1
—
—
—
0
0
6
30
2.01
0.87
1.3
1.3
—
—
—
0
0
126
1433
0.86
0.86
2.8
2.9
0.6
0.8
ug/l
1.24
86
936
30
222
1.37
0.85
10.0
2.1
—
—
—
0
0
6
31
1.94
0.84
9.7
6.0
—
—
—
0
0
26
189
1.39
0.82
11.1
1.9
—
—
—
0
0
6
32
1.88
0.82
1.2
2.2
—
—
—
0
0
5
98
0.51
0.78
1.2
1.1
—
—
—
0
0
9
53
1.71
0.75
1.2
1.1
—
—
—
0
0
9
55
1.64
0.73
1.1
2.3
—
—
—
0
0
5
25
2.01
0.72
3.2
2.9
—
—
—
0
0
9
56
1.61
0.72
2.4
1.4
—
—
—
0
0
7
40
1.76
0.71
2.7
3.1
—
—
—
0
0
700
7125
0.86
0.69
43.0
20.7
129.8
136.1
g/l
20.51
692
7012
700
7125
0.86
0.69
42.8
20.6
7.0
6.7
e9/l
3.40
689
6923
11
69
1.60
0.68
3.8
2.8
—
—
—
0
0
5
27
1.86
0.68
1.6
1.2
5.3
6.8
mmol/l
—
5
27
5
27
1.86
0.68
1.0
1.3
55.0
61.9
%
—
5
17
15
102
1.48
0.68
1.7
1.2
—
—
—
0
0
700
7123
0.86
0.67
42.7
20.6
4.4
4.5
e12/l
9.32
688
6921
700
7122
0.87
0.67
42.5
20.5
29.9
30.4
pg
7.24
693
7011
41
331
1.25
0.66
1.3
1.2
—
—
—
0
0
700
7121
0.87
0.66
42.6
20.5
90.6
91.0
fl
1.67
692
7011
598
6140
0.90
0.66
4.8
4.5
5.9
6.0
mmol/l
0.10
534
5572
64
544
1.19
0.64
2.4
2.2
11.9
13.1
nmol/l
0.47
56
482
30
234
1.29
0.63
10.0
2.1
—
—
—
0
0
700
7118
0.87
0.63
42.9
20.6
254.9
246.7
e9/l
2.12
689
6933
21
156
1.36
0.61
2.1
1.8
4.4
6.1
iu/l
0.28
11
51
80
698
1.16
0.60
1.3
1.3
—
—
—
0
0
30
237
1.28
0.59
10.2
2.1
—
—
—
0
0
10
64
1.57
0.58
1.5
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
76
663
1.16
0.57
2.3
4.3
408.4
26.5
ug/l
0.47
59
550
34
274
1.25
0.57
2.3
2.8
—
—
—
0
0
8
54
1.49
0.57
1.3
1.1
—
—
—
0
0
23
177
1.31
0.55
1.8
1.4
244.1
287.2
ug/g
0.56
17
97
460
4436
1.09
0.55
4.0
3.8
—
—
—
0
0
516
5312
0.92
0.53
36.0
17.1
14.2
13.7
%
9.65
508
5203
6
98
0.61
0.52
1.2
1.1
—
—
—
0
0
9
64
1.41
0.51
2.3
2.2
—
—
—
0
0
185
1721
1.10
0.51
1.5
1.4
—
—
—
0
0
7
108
0.65
0.49
1.4
1.4
—
—
—
0
0
7
108
0.65
0.49
1.4
1.3
—
—
—
0
0
51
591
0.85
0.48
1.3
1.4
—
—
—
0
0
29
235
1.24
0.48
10.9
1.9
—
—
—
0
0
7
111
0.63
0.48
1.4
1.5
—
—
—
0
0
677
6658
1.11
0.47
26.7
13.3
—
—
—
0
0
7
50
1.40
0.45
1.0
1.2
—
—
—
0
0
18
139
1.30
0.44
10.4
4.0
24.7
27.5
mg/l
0.19
11
89
32
266
1.21
0.44
1.2
1.3
—
—
—
0
0
10
70
1.43
0.42
3.1
2.4
—
—
—
0
0
12
161
0.74
0.41
1.1
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
7.0
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
17.8
—
0
15
11
79
1.40
0.41
2.8
1.5
—
—
—
0
0
11
79
1.40
0.41
2.8
1.5
—
—
—
0
0
11
79
1.40
0.41
2.8
1.5
—
—
—
0
0
11
79
1.40
0.41
2.8
1.5
—
—
—
0
0
8
60
1.34
0.40
1.5
1.7
—
—
—
0
0
36
307
1.18
0.39
1.9
2.4
—
—
—
0
0
10
136
0.73
0.38
1.6
1.3
—
—
—
0
0
28
236
1.19
0.35
10.3
2.1
—
—
—
0
0
6
46
1.31
0.33
1.3
1.2
—
—
—
0
0
577
5870
0.94
0.32
31.1
15.1
38.6
40.1
%
3.06
371
4209
9
72
1.25
0.25
1.1
1.4
0.2
0.4
nmol/l
—
9
57
80
744
1.08
0.25
2.0
2.4
110.2
120.8
ug/g
0.20
60
604
58
629
0.92
0.23
1.6
1.4
—
—
—
0
0
5
38
1.32
0.23
3.0
1.7
—
—
—
0
0
12
97
1.24
0.23
1.2
1.2
5.0
4.0
u/ml
—
5
38
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
17.4
—
0
10
161
1676
0.95
0.21
1.6
1.7
1.6
1.4
mmol/l
1.29
139
1400
0
12
0.00
0.21
0.0
8.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
6246.8
—
0
12
239
2462
0.96
0.20
4.6
4.8
4.0
2.4
ug/l
0.49
210
2186
65
695
0.93
0.20
1.6
1.7
—
—
—
0
0
20
174
1.15
0.20
2.0
2.4
114.0
96.5
ug/min
0.08
13
99
7
61
1.15
0.17
1.4
1.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.1
1.2
1.6
nmol/l
—
7
55
24
215
1.12
0.16
1.5
1.6
—
—
—
0
0
27
248
1.09
0.13
1.0
1.1
—
—
—
0
0
27
293
0.92
0.12
1.1
1.1
—
125.1
—
0
11
16
143
1.12
0.11
1.1
1.2
—
—
—
0
0
13
147
0.88
0.11
2.2
1.3
—
—
—
0
0
29
312
0.93
0.11
1.4
1.7
—
—
—
0
0
18
197
0.91
0.10
11.5
11.6
—
—
—
0
0
678
6811
0.97
0.09
15.4
10.2
26.9
27.0
u/l
0.02
655
6569
37
390
0.95
0.09
1.3
1.2
—
—
—
0
0
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
582
5845
0.98
0.05
6.5
5.7
39.8
40.0
mmol/mol
0.10
537
5395
43
417
1.03
0.04
1.2
1.2
114.5
159.0
iu/ml
0.25
17
174
11
101
1.09
0.04
1.3
1.1
0.8
1.9
u/ml
—
5
40
0
8
0.00
0.00
0.0
5.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
6
62
0.97
0.00
1.3
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
5.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_PARDIPLE and mortality.

Females

Parameter HR [95% CI] p-value
G6_PARDIPLE 3.284 [2.85, 3.78] < 0.001
Birth year 0.99 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 1018 out of 2755 females with G6_PARDIPLE died.

Males

Parameter HR [95% CI] p-value
G6_PARDIPLE 3.353 [2.93, 3.84] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1463 out of 3289 males with G6_PARDIPLE died.

Mortality risk

Mortality risk for people of age

years, who have G6_PARDIPLE.

N-year risk Females Males
1 0.264% 0.544%
5 1.408% 3.501%
10 3.74% 7.817%
15 7.163% 14.977%
20 12.565% 24.983%

Relationships between endpoints

Index endpoint: G6_PARDIPLE – Paraplegia, diplegia of upper limbs

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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