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Non-small cell lung cancer, squamous

HLP_C3_NSCLC_SQUAM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C34
  • Cancer registry: Morphology ICD-O-3 8070
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

1849

4. Check minimum number of events

None

1849

5. Include endpoints

None

1849

6. Filter based on genotype QC (FinnGen only)

1787

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1787 242 1545
Unadjusted period prevalence (%) 0.68 0.10 0.78
Median age at first event (years) 71.97 70.11 72.26

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1849
Matched controls
18491
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/3-C34.1
ICD-O-3
Squamous cell carcinoma, NOS, of upper lobe, lung
+∞
323.0
426
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
13.7
323.0
856
1095
C34.31
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung epidermoid carcinoma
246.2
323.0
503
28
C34.11
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary epidermoid carcinoma
186.9
323.0
670
56
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
12.2
323.0
941
1447
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
9532.9
323.0
981
*
8070/3-C34.3
ICD-O-3
Squamous cell carcinoma, NOS, of lower lobe, lung
+∞
323.0
348
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
20.9
323.0
591
407
130
Kela drug reimbursment
Malignant tumour
11.7
323.0
790
1105
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
26.2
323.0
464
233
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
25.3
227.0
326
155
GDC00
NOMESCO Finland
Lobectomy of lung
57.6
185.3
219
43
C34.81
ICD-10 Finland
Malignant overall tumor of bronchial and pulmonary epidermoid carcinoma
122.3
184.2
197
18
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
24.1
183.0
266
128
L01CA04
ATC
vinorelbine; systemic
63.3
157.3
183
32
H02AB02
ATC
dexamethasone; systemic
6.3
146.3
439
875
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.0
138.0
710
2488
A03FA01
ATC
metoclopramide; systemic, rectal
4.2
135.0
632
2025
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
22.9
134.7
198
96
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
39.9
121.5
154
42
C34.01
ICD-10 Finland
Malignant tumor of the main bronchial epidermoid carcinoma
115.5
119.7
129
12
C34.91
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary epidermoid carcinoma
135.1
118.7
126
10
C34.30
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung without histology
24.4
117.3
169
76
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
12.1
104.7
198
181
C34.19
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung other or unspecified histology
22.4
96.9
143
69
WF004
NOMESCO Finland
Palliative radiotherapy
11.8
93.8
179
166
A04AA01
ATC
ondansetron; systemic, rectal
6.8
93.6
253
421
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.0
90.3
268
504
1623A
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Upper lobe, bronchus or lung[NEOPL MAL LOB SUPER PULMONIS,CA EPIDERMOIDES]
91.0
85.9
95
11
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
19.7
84.0
129
70
N02AA05
ATC
oxycodone; systemic
3.2
81.1
535
2109
C34.21
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung epidermoid carcinoma
102.6
80.7
88
9
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
12.5
80.4
149
129
WF049
NOMESCO Finland
Radiotherapy of metastasis
7.4
74.7
187
276
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
12.6
72.8
134
114
Z51.5
ICD-10 Finland
Palliative care
4.4
71.9
286
735
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
9.6
68.1
144
161
R03BB04
ATC
tiotropium bromide; inhalant
3.1
67.5
453
1775
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
11.0
66.8
131
127
GD1AD
NOMESCO Finland
Thorax CT examination
6.0
65.0
191
349
GDD00
NOMESCO Finland
Pneumonectomy
141.1
64.3
68
5
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
8.3
64.3
148
191
R04.2
ICD-10 Finland
Haemoptysis
5.4
63.7
204
414
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
15.6
61.1
102
69
5826
FHL
Lobectomy or bilobectomy
36.6
57.7
74
21
C34.0
ICD-10 Finland
Malignant neoplasm: Main bronchus
22.5
57.5
84
39
R84
ICPC
Malignant neoplasm bronchus/lung
29.0
57.4
78
28
H02AB06
ATC
prednisolone; systemic
2.2
57.4
971
6167
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
56.2
827
4910
WF002
NOMESCO Finland
Radical radiotherapy
4.6
56.0
210
503
C34.39
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung other or unspecified histology
17.8
53.7
85
50
A04AA55
ATC
palonosetron, combinations; systemic
13.2
52.1
93
74
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.6
51.5
157
299
8070/3-C34.0
ICD-O-3
Squamous cell carcinoma, NOS, of main bronchus
+∞
51.3
49
*
TGD00
NOMESCO Finland
Needle biopsy of lung
26.3
51.0
71
28
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
23.0
49.1
71
32
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
17.2
47.6
76
46
XX3DW
NOMESCO Finland
Time consuming IT work
3.3
46.4
258
865
1625A
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Lower lobe, bronchus or lung[NEOPL MAL LOBI INFERIORIS PULMONIS,CA EPIDERMOIDES]
76.5
46.2
52
7
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
13.4
45.8
81
63
A98
ICPC
Health maint/preventive medicine
0.5
44.9
815
11320
YG1CD
NOMESCO Finland
Very extensive CT examination of thorax for dose design of radiotherapy
22.8
44.2
64
29
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.7
42.9
329
1361
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.9
40.4
176
482
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
10.0
37.9
77
80
R03AC02
ATC
salbutamol; inhalant
1.9
37.7
842
5621
8070/3-C34.2
ICD-O-3
Squamous cell carcinoma, NOS, of middle lobe, lung
+∞
37.6
36
*
J01MA14
ATC
moxifloxacin; systemic
3.0
37.4
243
900
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
12.6
36.6
66
54
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.6
35.2
170
507
JN4BD
NOMESCO Finland
Extensive body CT
2.6
34.7
277
1163
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.9
33.7
147
402
WZC30
NOMESCO Finland
Teaching
2.6
32.8
262
1097
J01MA12
ATC
levofloxacin; systemic
2.1
31.7
457
2543
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
4.5
31.7
117
274
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
25.0
31.5
44
18
N07BA03
ATC
varenicline; oral
5.9
31.2
90
160
C34.2
ICD-10 Finland
Malignant neoplasm: Middle lobe, bronchus or lung
18.2
31.0
48
27
5828
FHL
Pneumectomy
71.1
31.0
35
5
C34.89
ICD-10 Finland
Malignant overall tumor of the bronchus and lung other or unspecified histology
16.4
29.9
48
30
C34.80
ICD-10 Finland
Malignant overall tumor of bronchus and lung without histology
11.1
29.8
57
53
GEA00
NOMESCO Finland
Mediastinoscopy
27.2
29.3
40
15
A04AA02
ATC
granisetron; systemic, transdermal
3.6
29.2
139
409
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
6.6
28.0
73
114
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.6
27.9
230
975
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
27.9
345
1786
N06DX01
ATC
memantine; oral
0.2
27.6
20
1188
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
5.2
27.5
87
173
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.8
27.2
183
688
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
26.8
438
2538
C34
ICD-10 Finland
Malignant neoplasm of bronchus and lung
24.4
25.7
36
15
GDC10
NOMESCO Finland
Bilobectomy of lung
45.0
25.6
31
7
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.2
25.4
99
245
1240
FHL
Bronchoscopy
4.9
25.0
84
179
J70.0
ICD-10 Finland
Acute pulmonary manifestations due to radiation
43.5
24.6
30
7
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
24.3
476
2924
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.2
23.9
94
235
XG410
NOMESCO Finland
Flow-volume spirometry
3.4
23.6
117
356
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
7.6
23.4
55
74
C34.09
ICD-10 Finland
Malignant tumor of the main bronchus other or unspecified histology
17.5
23.1
36
21
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
7.9
23.1
53
69
N02AX02
ATC
tramadol; systemic, rectal
1.7
23.0
767
5522
R03BB01
ATC
ipratropium bromide; inhalant
2.4
23.0
203
891
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
22.9
312
1672
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
22.8
788
5726
1628A
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Other parts of bronchus or lung[NEOPL MAL PULMONIS LOCO MULTIPLICI,CA EPIDERMOIDES]
232.7
22.7
23
*
GD002
NOMESCO Finland
Radical radiotherapy of trachea, bronchi and lungs
+∞
21.9
21
*
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
0.5
21.6
262
4378
GD5CD
NOMESCO Finland
Thorax and upper abdomen combined very extensive CT examination of
10.5
21.6
42
41
1622A
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Main bronchus[NEOPL MAL BRONCH PRINCIP,CA EPIDERMOIDES]
116.4
21.6
23
*
SAA01
NOMESCO Finland
Simple examination of mouth
0.6
21.2
413
6102
SAA02
NOMESCO Finland
Basic examination of mouth
0.6
20.9
329
5131
I10
ICD-10 Finland
Essential (primary) hypertension
0.6
20.9
716
9304
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
4.4
20.8
77
182
GD2CT
NOMESCO Finland
Cytology of the lungs with CT guidance
30.4
20.6
27
9
N40
ICD-10 Finland
Hyperplasia of prostate
0.6
20.4
376
5645
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.2
20.3
28
1132
B02AA02
ATC
tranexamic acid; systemic
2.2
20.0
211
1009
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
0.2
19.7
22
1002
C77.1
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrathoracic lymph nodes
24.9
19.5
27
11
SFA10
NOMESCO Finland
Fillning on one surface of tooth
0.6
19.4
272
4389
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.4
19.3
115
2414
P20
ICPC
Memory disturbance
0.4
18.8
79
1889
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.1
18.7
73
182
GDB21
NOMESCO Finland
Thoracoscopic segmental resection of lung
33.2
18.0
23
7
JN4AD
NOMESCO Finland
Body CT examination
2.4
17.9
157
684
D38.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Respiratory organ, unspecified
10.5
17.7
34
33
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.5
17.7
189
3296
GCA05
NOMESCO Finland
Bronchoscopic laser therapy of lesion of bronchus
96.0
17.6
19
*
GDC20
NOMESCO Finland
Lobectomy of lung and sleeve resection of bronchus
96.0
17.6
19
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.6
17.5
80
229
J01AA02
ATC
doxycycline; systemic
1.6
17.4
1264
10734
GD2AT
NOMESCO Finland
Cytology of the lungs with ultrasound guidance
18.8
17.3
26
14
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
4.4
17.3
62
143
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
3.4
17.1
84
255
2391A
ICD-9 Finland
Neoplasm of unspecified nature, Respiratory system
7.8
17.1
39
51
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.1
16.9
96
323
N02AA01
ATC
morphine; systemic, rectal
3.8
16.9
72
195
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
6.3
16.7
44
71
WX250
NOMESCO Finland
Intercostal blockade
23.3
16.4
23
10
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
0.5
16.3
155
2806
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
9.3
16.2
33
36
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
15.9
149
671
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.6
15.9
73
211
M17.1
ICD-10 Finland
Other primary gonarthrosis
0.5
15.8
116
2278
EB1AA
NOMESCO Finland
Tooth X-ray examination
0.6
15.7
312
4663
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
4.3
15.7
58
138
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
15.7
334
2071
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.6
15.6
121
493
XKD00
NOMESCO Finland
Uroflowmetry
0.5
15.5
193
3242
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.1
15.4
182
913
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
5.0
15.4
49
100
A04AD12
ATC
aprepitant; systemic
6.6
15.4
39
60
Z72.0
ICD-10 Finland
Tobacco use
4.6
15.4
53
118
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
0.5
15.3
115
2244
ZX070
NOMESCO Finland
Intensity modified radiotherapy
4.2
15.3
58
142
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
10.5
15.2
29
28
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
15.2
210
1121
F03
ICD-10 Finland
Unspecified dementia
0.3
15.2
24
901
C10AA05
ATC
atorvastatin; oral
0.6
14.9
387
5461
TGE00
NOMESCO Finland
Needle biopsy of mediastinum
15.2
14.9
24
16
ZX095
NOMESCO Finland
Combined chemoradiotherapy
12.5
14.9
26
21
C61
ICD-10 Finland
Malignant neoplasm of prostate
0.5
14.9
123
2330
K02.1
ICD-10 Finland
Caries of dentine
0.6
14.7
306
4535
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
7.8
14.6
33
43
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
0.5
14.6
178
3011
L03AA13
ATC
pegfilgrastim; parenteral
3.7
14.3
63
176
N06DA03
ATC
rivastigmine; oral, transdermal
0.2
14.1
9
583
C34.20
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung without histology
14.5
14.1
23
16
ZX120
NOMESCO Finland
Intravenous
2.0
14.0
188
993
1CD01
NOMESCO Finland
NA
17.7
13.8
21
12
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
13.8
263
1571
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.3
13.7
70
220
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
4.0
13.7
55
142
KMAK
NOMESCO Finland
NA
0.6
13.7
285
4237
PJD99
NOMESCO Finland
Excision of other lymph nodes
75.7
13.6
15
*
N06DA02
ATC
donepezil; oral
0.3
13.5
30
954
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
13.5
254
1511
L15
ICPC
Knee symptom/complaint
0.4
13.1
74
1594
C34.15
ICD-10 Finland
Malignant tumor of the anterior, bronchial or lung other non-microcellular carcinoma
12.2
13.1
23
19
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.4
12.9
65
1459
K03.64
ICD-10 Finland
Dental calculus supragingival
0.4
12.9
72
1559
1BC05
NOMESCO Finland
NA
50.3
12.8
15
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
0.2
12.6
15
662
R85
ICPC
Malignant neopl respiratory other
32.2
12.6
16
5
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
6.0
12.6
34
58
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
0.6
12.5
158
2662
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
0.6
12.5
267
3956
SPAT1301
SPAT
No procedures
0.6
12.4
253
3788
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
6.5
12.3
31
48
SDA01
NOMESCO Finland
Simple parodonthologic therapy
0.5
12.3
79
1625
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
12.3
634
4862
S18
ICPC
Laceration/cut
0.6
12.2
344
4811
GEA20
NOMESCO Finland
Mediastinoscopy with excision of lesion
16.0
12.1
19
12
VALMI
NOMESCO Finland
NA
0.5
12.1
78
1604
191
Kela drug reimbursment
Erlotinib
12.5
12.1
21
17
J01FA06
ATC
roxithromycin; oral
1.5
12.1
600
4557
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
8.7
12.0
25
29
H81
ICPC
Excessive ear wax
0.5
12.0
114
2074
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
11.9
234
3534
A06AH03
ATC
naloxegol; oral
5.3
11.8
35
67
C34.32
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung adenocarcinoma
4.8
11.7
38
81
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
4.8
11.7
38
81
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.6
11.6
85
339
L57.0
ICD-10 Finland
Actinic keratosis
0.4
11.6
56
1277
C34.35
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung other non-microcellular carcinoma
19.0
11.6
17
9
D70.82
ICD-10 Finland
Drug-induced neutropenia
5.0
11.6
36
73
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
9.3
11.5
23
25
1624A
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Middle lobe, bronchus or lung[NEOPL MAL LOBI MEDII PULMONIS,CA EPIDERMOIDES]
+∞
11.5
11
*
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
0.5
11.4
109
1985
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
0.5
11.4
89
1720
Z01.2
ICD-10 Finland
Dental examination
0.6
11.4
183
2902
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
0.1
11.3
7
463
R03DA04
ATC
theophylline; systemic, rectal
1.8
11.2
209
1239
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
3.7
11.2
48
133
A06AC01
ATC
ispaghula (psylla seeds); oral
0.6
11.2
162
2634
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
0.6
10.9
134
2276
GWE00
NOMESCO Finland
Reoperation for deep haemorrhage in thoracic surgery
43.6
10.9
13
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
0.4
10.9
63
1344
A02BX02
ATC
sucralfate; oral
2.2
10.9
108
503
J43.9
ICD-10 Finland
Emphysema, unspecified
2.9
10.8
64
226
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
0.5
10.8
77
1534
GAA31
NOMESCO Finland
Thoracoscopy
9.6
10.7
21
22
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
60.3
10.6
12
*
J86.9
ICD-10 Finland
Pyothorax without fistula
4.7
10.6
35
76
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
0.7
10.6
329
4539
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.2
10.5
108
512
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
0.6
10.4
146
2399
8070/3-C34.8
ICD-O-3
Squamous cell carcinoma, NOS, of overlapping lesion of lung
+∞
10.4
10
*
SPAT1153
SPAT
Removal of sutures
0.6
10.3
240
3511
GDA10
NOMESCO Finland
Biopsy of lung
12.1
10.3
18
15
G30.8
ICD-10 Finland
Other Alzheimer disease
0.1
10.3
*
346
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
0.1
10.3
*
318
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
0.3
10.3
21
694
TGC00
NOMESCO Finland
Bronchial lavation
2.9
10.2
61
216
GCA32
NOMESCO Finland
Endoscopic insertion of stent into bronch
23.5
10.2
14
6
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
0.6
10.2
212
3177
SPAT1053
SPAT
Memory test
0.6
10.1
147
2395
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
5.9
10.1
27
46
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
5.4
10.1
29
54
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
0.4
10.1
48
1100
D01AE16
ATC
amorolfine; topical
0.4
10.1
52
1156
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
0.4
10.0
40
979
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
0.7
10.0
388
5153
D19
ICPC
Teeth/gum symptom/complaint
0.5
10.0
89
1656
C34.29
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung other or unspecified histology
14.7
10.0
16
11
1629A
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Bronchus and lung, unspecified[NEOPL MAL PULMONIS LOCO ALIO/NUD,CA EPIDERMOIDES]
40.3
10.0
12
*
YX9CD
NOMESCO Finland
Other very extensive CT eamination for dose design of radiotherapy
16.8
9.9
15
9
GD004
NOMESCO Finland
Palliative radiotherapy of trachea, bronchi and lungs
16.8
9.9
15
9
ZX050
NOMESCO Finland
Stereotactic radiotherapy
4.8
9.8
31
65
XG460
NOMESCO Finland
Short time oxymetry
2.7
9.8
63
235
H13
ICPC
Plugged feeling ear
0.6
9.7
127
2122
UGC02
NOMESCO Finland
Rigid bronchoscopy
13.4
9.7
16
12
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
5.8
9.7
26
45
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
0.4
9.6
51
1122
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.7
9.6
64
242
C10AA07
ATC
rosuvastatin; oral
0.6
9.5
154
2448
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
3.9
9.5
38
100
UKC02
NOMESCO Finland
Cystoscopy
0.6
9.5
206
3064
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
0.6
9.5
210
3111
SPAT1256
SPAT
Intramuscular and subcutaneous injection
0.7
9.5
355
4748
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.7
9.5
449
5773
SPAT1043
SPAT
Audiometry
0.5
9.4
56
1187
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
3.3
9.4
46
143
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
5.4
9.4
27
51
C08CA01
ATC
amlodipine; oral
0.7
9.3
399
5222
7866A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Swelling, mass, or lump in chest
9.6
9.3
18
19
I50.9
ICD-10 Finland
Heart failure, unspecified
0.6
9.2
207
3059
G04CA02
ATC
tamsulosin; oral
0.7
9.2
483
6115
M01AX05
ATC
glucosamine; oral
0.6
9.2
139
2240
J93.8
ICD-10 Finland
Other pneumothorax
6.7
9.1
22
33
R33
ICD-10 Finland
Retention of urine
0.5
9.1
101
1766
1623X
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Upper lobe, bronchus or lung[NEOPL MAL LOB SUPER PULMONIS,EI HIST/SYTOL DG]
8.3
9.1
19
23
TGA30
NOMESCO Finland
Thoracocentesis
3.9
9.0
35
90
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
7.1
9.0
21
30
L01XE03
ATC
[U] erlotinib; oral
10.1
9.0
17
17
-1
NOMESCO Finland
NA
0.6
9.0
151
2382
XJH00
NOMESCO Finland
Transanal ultrasonography
0.5
9.0
70
1356
C09AA02
ATC
enalapril; systemic
0.7
8.9
246
3489
WF003
NOMESCO Finland
Adjuvant radiotherapy
2.8
8.9
57
211
116
Kela drug reimbursment
Prostate cancer
0.5
8.9
76
1434
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
0.7
8.9
295
4040
D82
ICPC
Teeth/gum disease
0.6
8.8
141
2250
R95
ICPC
Chron obstructive pulmonary disease
2.4
8.8
71
302
R24
ICPC
Haemoptysis
5.6
8.7
24
43
A02BA02
ATC
ranitidine; systemic
1.5
8.7
378
2768
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
3.7
8.6
36
99
DFF00
NOMESCO Finland
Pure tone audiometry
0.4
8.6
32
803
C10AA01
ATC
simvastatin; oral
0.7
8.6
612
7421
G04CA52
ATC
tamsulosin and dutasteride; systemic
0.6
8.5
102
1748
H02
ICPC
Hearing complaint
0.5
8.4
74
1382
WX330
NOMESCO Finland
Paravertebral ansthesia
90.4
8.4
9
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.3
8.4
76
341
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
7.9
8.4
18
23
M01AH05
ATC
etoricoxib; oral
0.7
8.3
396
5109
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
2.5
8.3
64
266
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
0.5
8.2
50
1050
G04CA01
ATC
alfuzosin; oral
0.6
8.1
149
2303
5188X
ICD-9 Finland
Other diseases of lung
4.9
8.1
25
52
SDA02
NOMESCO Finland
Parodonthologic therapy
0.6
8.0
152
2334
R06.0
ICD-10 Finland
Dyspnoea
1.4
8.0
420
3182
I25.1
ICD-10 Finland
Atherosclerotic heart disease
0.7
8.0
389
5010
N02BE01
ATC
paracetamol; systemic, rectal
0.8
8.0
1036
11619
L82
ICD-10 Finland
Seborrhoeic keratosis
0.5
8.0
77
1397
Z01.1
ICD-10 Finland
Examination of ears and hearing
0.5
7.9
87
1527
G04BD12
ATC
mirabegron; oral
0.5
7.9
50
1036
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
0.6
7.9
91
1574
R31
ICD-10 Finland
Unspecified haematuria
0.6
7.8
117
1898
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
0.4
7.8
28
716
GDC13
NOMESCO Finland
Extended lobectomy or bilobectomy of lung
45.2
7.7
9
*
R05CB01
ATC
acetylcysteine; inhalant, oral
2.4
7.7
60
250
F01.9
ICD-10 Finland
Vascular dementia, unspecified
0.1
7.7
*
273
WW200
SPAT
NA
0.3
7.7
17
537
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.4
7.6
357
2646
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.3
7.6
68
304
C79.31
ICD-10 Finland
Secondary malignant tumor of the cerebellum
11.9
7.6
13
11
114
Kela drug reimbursment
Glaucoma
0.5
7.6
73
1330
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
0.5
7.6
83
1458
GAC00
NOMESCO Finland
Biopsy of pleura
5.4
7.5
21
39
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
4.7
7.5
24
52
R03AL05
ATC
formoterol and aclidinium bromide; inhalant
7.1
7.5
17
24
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
0.5
7.5
51
1028
R53
ICD-10 Finland
Malaise and fatigue
0.6
7.5
168
2485
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
2.8
7.5
44
157
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
3.1
7.4
38
124
N02AC04
ATC
dextropropoxyphene; oral
1.9
7.4
110
605
1440
FHL
Mediastinoscopy
10.9
7.3
13
12
M79.6
ICD-10 Finland
Pain in limb
0.7
7.2
239
3290
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
0.6
7.2
104
1703
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
0.6
7.2
139
2124
C34.95
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other non-microcellular carcinoma
20.1
7.1
10
5
PD3YT
NOMESCO Finland
Pelvic artery PTA with stent
3.4
7.1
32
95
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.4
7.1
32
95
I25
ICD-10 Finland
Chronic ischaemic heart disease
0.4
7.1
31
730
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
0.2
7.0
9
378
R81
ICPC
Pneumonia
2.4
7.0
57
245
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
0.4
7.0
23
609
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
7.0
108
1740
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.9
6.9
40
140
I50.0
ICD-10 Finland
Congestive heart failure
0.6
6.9
101
1648
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
13.8
6.9
11
8
N06DA04
ATC
galantamine; oral
0.2
6.9
6
316
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.8
354
2668
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
6.7
6.8
16
24
KED22
NOMESCO Finland
Transurethral resection of prostate
0.6
6.8
90
1505
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
2.9
6.8
39
136
GDB20
NOMESCO Finland
Segmental resection of lung
40.2
6.8
8
*
S29
ICPC
Skin symptom/complaint other
0.6
6.8
93
1541
1625X
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Lower lobe, bronchus or lung[NEOPL MAL LOBI INFERIORIS PULMONIS,EI HIST/SYTOL DG]
16.7
6.7
10
6
JN5AP
NOMESCO Finland
Total body PET (1 picture)
16.7
6.7
10
6
J93.9
ICD-10 Finland
Pneumothorax, unspecified
4.7
6.7
21
45
J01DB01
ATC
cefalexin; oral
0.8
6.7
910
10272
N05AX08
ATC
risperidone; systemic
0.5
6.7
55
1050
C09CA01
ATC
losartan; oral
0.7
6.7
205
2861
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
4.4
6.7
22
50
SPAT1325
SPAT
Vaccination
0.7
6.6
351
4484
SPAT1109
SPAT
Analgesia with portable analgesic pump
5.5
6.6
18
33
WX600
NOMESCO Finland
Single shot through catheter
4.6
6.6
21
46
C34.13
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary bronchoalveolar carcinoma
12.3
6.6
11
9
J94.8
ICD-10 Finland
Other specified pleural conditions
2.5
6.6
47
189
J01MA02
ATC
ciprofloxacin; systemic
0.8
6.6
459
5641
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
0.6
6.6
138
2077
J01DA01
ATC
[U] cefalexin; systemic
1.3
6.6
964
8478
N05BA04
ATC
oxazepam; oral
1.4
6.6
349
2644
Z57.2
ICD-10 Finland
Occupational exposure to dust
6.9
6.5
15
22
D01BA02
ATC
terbinafine; oral; topical
0.7
6.4
189
2658
Z97.4
ICD-10 Finland
Presence of external hearing-aid
0.4
6.4
31
705
P70
ICPC
Dementia
0.2
6.4
5
280
205
Kela drug reimbursment
Chronic hypertension
0.8
6.4
442
5442
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.0
6.3
80
415
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
2.1
6.3
69
339
S01ED51
ATC
timolol, combinations; ophthalmic
0.5
6.3
53
1000
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
0.4
6.3
26
628
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
2.4
6.3
51
219
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.6
6.3
138
2053
L01XE13
ATC
[U] afatinib; oral
+∞
6.3
6
*
GBA22
NOMESCO Finland
Endoscopic excision of lesion of trachea
+∞
6.3
6
*
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
3.2
6.2
30
95
UJF32
NOMESCO Finland
Coloscopy
0.7
6.2
233
3146
JN6AD
NOMESCO Finland
CT of torso and neck
4.1
6.2
22
54
C78.2
ICD-10 Finland
Secondary malignant neoplasm of pleura
7.7
6.1
13
17
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
0.4
6.1
20
527
L02AE02
ATC
leuprorelin; implant, parenteral
0.5
6.1
48
928
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
8.6
6.1
12
14
J01CA08
ATC
pivmecillinam; oral
0.7
6.0
144
2109

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: HLP_C3_NSCLC_SQUAM – Non-small cell lung cancer, squamous

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).