Dyshidrosis [pompholyx]

L12_DYSHIDROSIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L30.1
  • Hospital discharge: ICD-9 7058A
  • Hospital discharge: ICD-8 69283
  • Cause of death: ICD-10 L30.1
  • Cause of death: ICD-9 7058A
  • Cause of death: ICD-8 69283

2 out of 7 registries used, show all original rules.

592

4. Check minimum number of events

None

592

5. Include endpoints

None

592

6. Filter based on genotype QC (FinnGen only)

592

Control definitions (FinnGen only)

Control exclude
L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L30
Name in latin
Pompholyx

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3645 2184 1440
Only index persons 3395 2092 1303
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.07 0.08 0.05
Median age at first event (years)
Whole population 39.06 39.22 38.77
Only index persons 38.66 38.88 38.32

-FinnGen-

Key figures

All Female Male
Number of individuals 592 405 187
Unadjusted period prevalence (%) 0.12 0.14 0.08
Median age at first event (years) 42.36 42.27 42.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
532
Matched controls
5320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L30.1
ICD-10 Finland
Dyshidrosis [pompholyx]
+∞
323.0
479
*
XQ802
NOMESCO Finland
Epicutan test
351.5
209.3
199
9
L20.0
ICD-10 Finland
Besnier prurigo
+∞
153.8
140
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
20.4
141.4
227
187
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
139.9
128
*
D07AC13
ATC
mometasone; topical
9.9
123.7
336
786
D07AC01
ATC
betamethasone; topical
8.4
109.4
343
947
E0000UV
ATC
NA
8.0
105.9
374
1211
D07AD01
ATC
clobetasol; topical
10.9
103.3
226
336
L30.9
ICD-10 Finland
Dermatitis, unspecified
11.9
102.2
210
276
XQ800
NOMESCO Finland
Prick test
16.6
97.2
165
140
L30.3
ICD-10 Finland
Infective dermatitis
48.2
73.5
89
22
D07BC01
ATC
betamethasone and antiseptics; topical
8.8
68.3
162
251
E000001
ATC
NA
5.4
56.0
205
553
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
55.2
52
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
50.8
48
*
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
535.4
50.3
49
*
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
263.0
47.8
48
*
D02AE01
ATC
carbamide; topical
9.2
42.2
93
120
D07CC01
ATC
betamethasone and antibiotics; topical
5.5
41.4
138
319
D07AB02
ATC
hydrocortisone butyrate; topical
3.7
37.0
210
801
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
5.2
36.8
126
297
L30.0
ICD-10 Finland
Nummular dermatitis
19.2
35.3
54
31
D11AH01
ATC
tacrolimus; topical
+∞
34.8
33
*
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
347.4
33.3
33
*
L20
ICD-10 Finland
Atopic dermatitis
+∞
30.5
29
*
L30.8
ICD-10 Finland
Other specified dermatitis
18.8
29.3
45
26
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
28.4
27
*
H02AB06
ATC
prednisolone; systemic
2.8
28.1
288
1573
TQW80
NOMESCO Finland
Local dermatologic skincare
17.2
27.2
43
27
D07AB08
ATC
desonide; topical
4.9
26.9
94
221
D07CB01
ATC
triamcinolone and antibiotics; topical
17.4
26.7
42
26
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
3.2
25.3
162
640
E000002
ATC
NA
4.4
25.0
99
264
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
5.0
22.4
76
172
H02AB04
ATC
methylprednisolone; systemic
3.6
22.0
111
364
R06AE07
ATC
cetirizine; oral
2.4
21.4
281
1671
L24.0
ICD-10 Finland
Irritant contact dermatitis due to detergents
+∞
21.0
20
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
20.3
100
321
L25.9
ICD-10 Finland
Unspecified contact dermatitis, unspecified cause
47.9
19.3
23
5
J01DB01
ATC
cefalexin; oral
2.9
18.9
460
3657
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
19.6
18.8
28
15
WQ021
NOMESCO Finland
NA
196.5
18.6
19
*
D07XC01
ATC
betamethasone, combinations; topical
3.6
17.6
84
261
E000004
ATC
NA
11.7
17.5
32
29
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.6
17.4
63
152
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
+∞
16.7
16
*
E000007
ATC
NA
5.4
16.6
51
103
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
175.2
16.6
17
*
R06AE09
ATC
levocetirizine; oral
2.8
15.7
110
448
SPAT1263
SPAT
Sampling
2.2
15.6
250
1552
D02AX
ATC
Other emollients and protectives
7.6
14.7
34
47
WQ007
NOMESCO Finland
NA
+∞
14.6
14
*
S87
ICPC
Dermatitis/atopic eczema
10.5
14.1
27
27
R06AX27
ATC
desloratadine; oral
2.2
13.8
177
983
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
5.2
13.7
43
89
WQ020
NOMESCO Finland
NA
143.4
13.5
14
*
D07XB05
ATC
dexamethasone, combinations; topical
8.9
13.4
28
33
D09AB01
ATC
zinc bandage without supplements; topical
14.3
13.3
22
16
L23
ICD-10 Finland
Allergic contact dermatitis
41.2
13.2
16
*
A46
ICD-10 Finland
Erysipelas
3.2
12.9
71
243
R06AX22
ATC
ebastine; oral
2.4
12.7
117
553
L24.8
ICD-10 Finland
Irritant contact dermatitis due to other agents
+∞
12.5
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
12.2
198
1203
N05BB01
ATC
hydroxyzine; systemic
3.9
12.1
51
142
H02AB07
ATC
prednisone; oral
2.9
11.9
77
296
E000006
ATC
NA
4.1
11.9
46
119
SPAT1310
SPAT
Counselling related to known health issue
2.0
11.7
188
1133
M01AE02
ATC
naproxen; oral, rectal
1.9
11.5
318
2336
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
11.5
11
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
5.3
11.1
33
65
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
10.9
49
145
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
10.7
229
1524
J01AA04
ATC
lymecycline; systemic
2.3
10.5
101
483
D11AX14
ATC
[U] tacrolimus; topical
+∞
10.4
10
*
S76
ICPC
Skin infection other
4.7
10.2
34
76
E000003
ATC
NA
4.6
10.1
34
77
R03AC02
ATC
salbutamol; inhalant
1.8
10.1
282
2037
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
14.9
10.0
16
11
Z01.2
ICD-10 Finland
Dental examination
1.8
10.0
244
1682
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
17.1
9.9
15
9
J01DA01
ATC
[U] cefalexin; systemic
1.8
9.8
336
2586
ND1BA
NOMESCO Finland
Wrist extensive X-ray examination
5.4
9.7
28
54
T78.4
ICD-10 Finland
Allergy, unspecified
4.1
9.6
37
96
S88
ICPC
Dermatitis contact/allergic
7.8
9.5
21
28
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.5
9.5
78
344
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
101.7
9.4
10
*
M03BX02
ATC
tizanidine; oral
1.8
9.4
336
2602
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
9.4
9
*
D07AA02
ATC
hydrocortisone; topical
2.4
9.3
80
361
XG410
NOMESCO Finland
Flow-volume spirometry
4.9
9.2
29
62
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
9.1
61
239
S21
ICPC
Skin texture symptom/complaint
2.6
8.8
65
269
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
8.8
74
330
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
8.8
259
1874
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
50.8
8.7
10
*
D05BB02
ATC
acitretin; oral
7.1
8.6
20
29
N03AX16
ATC
pregabalin; oral
2.0
8.5
126
720
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.7
8.5
36
102
L17
ICPC
Foot/toe symptom/complaint
2.0
8.5
124
708
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
91.4
8.4
9
*
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
+∞
8.4
8
*
R03BA05
ATC
fluticasone; inhalant
2.1
8.3
103
547
L08.0
ICD-10 Finland
Pyoderma
14.8
8.2
13
9
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.9
8.2
146
891
Z04.3
ICD-10 Finland
Examination and observation following other accident
5.5
8.2
23
43
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.0
441
3810
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
8.0
93
480
C01CA24
ATC
epinephrine; parenteral
3.2
8.0
40
130
J01FF01
ATC
clindamycin; systemic
1.9
8.0
138
836
R01AD09
ATC
mometasone; nasal
1.7
7.9
249
1819
L12
ICPC
Hand/finger symptom/complaint
2.2
7.8
81
398
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
7.7
283
2151
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
18.7
7.6
11
6
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.5
7.6
34
102
B35.3
ICD-10 Finland
Tinea pedis
3.9
7.5
29
77
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.5
7.4
55
230
H25.8
ICD-10 Finland
Other senile cataract
3.0
7.3
41
143
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
7.3
88
463
G47.3
ICD-10 Finland
Sleep apnoea
2.0
7.2
104
588
PA7BD
NOMESCO Finland
CT angiography of neck and brain
8.1
7.1
15
19
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.1
196
1365
L03
ICPC
Low back symptom/complaint
1.9
7.1
122
735
J01MA12
ATC
levofloxacin; systemic
2.1
7.1
85
448
SPAT1311
SPAT
Counselling and guidance related to occupational health
3.5
6.9
30
88
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
6.8
35
117
R01AD08
ATC
fluticasone; nasal
1.7
6.7
157
1041
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
6.6
209
1506
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
6.6
136
867
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.8
6.6
131
824
XQ848
NOMESCO Finland
Dermatological photography
5.4
6.5
18
34
SPAT1312
SPAT
General health counselling
1.7
6.5
179
1240
L01
ICPC
Neck symptom/complaint
2.1
6.5
77
403
XQ899
NOMESCO Finland
Other assessment of skin
70.6
6.4
7
*
L27.2
ICD-10 Finland
Dermatitis due to ingested food
70.6
6.4
7
*
A02BC02
ATC
pantoprazole; systemic
1.6
6.4
301
2395
L16
ICPC
Ankle symptom/complaint
2.3
6.4
59
276
Z00.0
ICD-10 Finland
General medical examination
1.9
6.3
101
589
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
6.3
68
342
WX402
NOMESCO Finland
General anaesthesia
0.4
6.3
23
566
D82
ICPC
Teeth/gum disease
1.6
6.3
197
1412
WQ055
NOMESCO Finland
NA
+∞
6.3
6
*
D11AH02
ATC
pimecrolimus; topical
+∞
6.3
6
*
D11AH04
ATC
alitretinoin; oral
+∞
6.3
6
*
L24.9
ICD-10 Finland
Irritant contact dermatitis, unspecified cause
+∞
6.3
6
*
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
+∞
6.3
6
*
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
7.2
6.3
14
20
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
6.2
140
912
J20
ICD-10 Finland
Acute bronchitis
2.3
6.2
55
251
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.2
229
1710
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
6.2
57
264
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
6.4
6.2
15
24
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.3
6.2
55
254
S06
ICPC
Rash localized
3.1
6.1
31
104
B86
ICD-10 Finland
Scabies
5.7
6.0
16
29
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.6
6.0
43
177
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.0
125
795

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
171
388
5.79
75.01
4.0
3.9
—
—
—
0
0
144
306
5.90
67.36
1.3
1.2
359.0
158.9
u/ml
2.24
135
280
162
503
4.06
46.19
1.5
1.3
—
—
—
0
0
249
1175
2.93
34.66
4.0
3.3
—
—
—
0
0
76
167
5.07
33.22
3.6
3.0
—
—
—
0
0
120
401
3.50
29.69
1.3
1.2
—
—
—
0
0
65
139
5.13
29.24
1.4
1.2
—
—
—
0
0
85
229
4.17
28.68
3.6
3.0
5.2
5.1
kpa
0.16
79
213
216
1091
2.54
24.63
2.2
2.0
—
—
—
0
0
266
1499
2.41
23.64
5.7
5.7
—
—
—
0
0
32
45
7.46
21.82
1.1
1.2
—
—
—
0
0
342
4438
0.46
18.57
14.5
14.1
332.4
332.8
g/l
0.36
342
4412
339
2273
2.15
18.20
6.1
5.8
29.4
29.3
%
0.06
316
2138
330
2199
2.13
17.90
6.4
6.1
8.0
8.3
%
0.80
312
2074
328
2184
2.13
17.78
6.0
5.8
3.1
2.8
%
1.84
307
2044
107
2136
0.39
17.65
9.4
8.3
0.0
0.0
e9/l
0.60
89
1761
334
2248
2.11
17.49
5.9
5.6
56.1
56.5
%
0.31
312
2123
210
3178
0.47
16.40
3.2
3.3
—
—
—
0
0
313
2115
2.02
15.55
6.1
5.8
0.7
0.7
%
1.13
292
1980
81
313
2.84
15.18
1.2
1.2
—
—
—
0
0
343
2435
1.97
14.35
6.1
6.0
0.2
0.2
e9/l
4.20
311
2171
130
658
2.25
13.69
1.7
1.7
820.9
1173.3
nmol/l
5.78
90
498
199
1203
1.99
13.03
1.4
1.2
1.0
1.8
u/ml
0.84
30
320
231
1471
1.94
12.98
2.1
2.1
—
—
—
0
0
40
112
3.76
12.64
1.3
1.4
25.7
19.3
u/l
0.54
32
93
326
2337
1.88
12.58
6.0
5.6
0.0
0.0
e9/l
3.63
305
2051
321
2329
1.83
11.54
5.9
5.6
0.6
0.5
e9/l
1.41
300
2046
361
2717
1.84
11.49
7.6
8.7
4.2
4.0
e9/l
0.95
332
2395
327
2410
1.80
10.93
6.0
5.6
2.0
2.0
e9/l
0.05
301
2159
231
1536
1.83
10.90
4.8
6.6
1.2
1.1
inr
0.38
25
490
436
3513
1.91
10.83
4.5
3.7
10.6
10.0
mm/h
0.55
391
3269
239
1640
1.77
9.92
1.9
1.8
107.2
97.5
pmol/l
1.88
139
866
207
1364
1.80
9.85
2.9
2.4
56.3
55.6
u/l
0.07
191
1259
36
113
3.33
9.61
1.2
1.2
3.2
3.2
u/ml
—
5
14
224
1524
1.76
9.48
3.4
3.0
43.6
28.4
ng/l
0.35
136
892
257
1831
1.71
9.13
5.1
5.1
1.2
1.2
mmol/l
1.18
212
1663
70
326
2.30
8.82
3.5
2.9
4.5
4.1
e9/l
0.47
38
272
426
3509
1.76
8.64
7.2
7.0
79.0
75.6
u/l
0.61
399
3288
45
173
2.73
8.48
1.3
1.7
—
—
—
0
0
116
668
1.92
8.33
2.3
2.4
269.7
108.1
ug/g
1.01
83
522
162
1044
1.76
8.06
1.5
1.5
2.6
2.3
g/l
0.67
90
650
116
675
1.89
8.05
1.4
1.3
396.5
519.7
titre
0.85
23
136
517
4561
2.05
7.94
5.6
4.6
7.4
2.1
mu/l
0.46
460
4237
14
25
5.71
7.57
1.0
1.8
4.7
6.7
ug/l
0.88
14
20
89
484
1.99
7.52
1.5
1.5
—
—
—
0
0
62
297
2.21
7.30
1.3
1.4
—
—
—
0
0
27
86
3.24
7.07
1.6
1.4
—
—
—
0
0
295
2278
1.59
7.04
5.4
5.9
9.4
10.6
umol/l
1.57
273
2149
16
36
4.54
6.74
1.8
4.1
59.9
56.0
%
—
10
27
75
1294
0.52
6.65
2.3
3.4
0.0
0.0
estimate
0.88
16
464
446
3840
1.65
6.42
4.5
3.9
14.7
14.5
pmol/l
0.96
392
3514
253
1919
1.56
6.32
2.0
2.0
—
—
—
0
0
156
1060
1.64
6.18
2.0
2.0
2.9
2.8
mg/l
0.08
123
903
103
1586
0.58
6.07
3.2
3.2
8.4
96.5
e6/l
3.57
67
1045
66
1150
0.52
5.96
3.1
2.7
0.3
0.4
e6/l
0.73
39
843
176
1242
1.59
5.94
2.0
2.0
201.8
219.6
u/l
0.08
171
1175
72
1218
0.53
5.89
5.0
3.8
7.4
7.4
ph
1.19
11
223
322
2603
1.52
5.84
3.9
3.9
6.5
6.5
mmol/l
0.08
292
2375
16
41
3.98
5.75
1.6
4.9
—
—
—
0
0
540
4962
2.00
5.55
13.5
11.0
21.6
20.7
mg/l
0.22
445
3797
13
435
0.28
5.45
3.0
3.3
—
—
—
0
0
68
1144
0.54
5.41
2.9
2.6
—
—
—
0
0
261
2048
1.49
5.29
6.7
6.0
1.2
1.2
mmol/l
1.40
227
1725
184
2386
0.67
4.83
4.0
4.3
0.0
0.0
estimate
0.50
18
467
18
57
3.23
4.80
2.0
3.7
1.0
0.7
%
—
10
47
155
1116
1.53
4.64
2.3
2.4
2507.0
6532.3
umol/l
0.90
125
980
188
2414
0.68
4.63
2.7
3.2
0.0
0.0
estimate
0.50
16
456
64
1050
0.56
4.59
2.9
3.1
—
—
—
0
0
147
1978
0.66
4.57
2.3
2.5
—
—
—
0
0
132
922
1.56
4.53
1.5
1.5
18.6
20.6
nmol/l
1.06
102
783
476
4282
1.57
4.52
6.3
5.0
38.9
38.8
mmol/mol
0.10
421
4012
127
880
1.56
4.51
1.4
1.3
24.4
29.6
iu/ml
0.27
38
277
85
1280
0.61
4.36
2.6
2.8
14.4
100.6
e6/l
0.98
58
960
510
4675
1.66
4.35
4.9
3.9
5.8
5.8
mmol/l
0.24
440
4315
382
3299
1.45
4.34
4.2
3.8
—
—
—
0
0
186
2370
0.69
4.29
2.5
3.1
0.0
0.0
estimate
0.00
17
451
15
46
3.32
4.21
2.4
3.1
—
—
—
0
0
5
217
0.22
4.18
1.4
1.4
—
—
—
0
0
558
5261
2.06
4.17
11.5
9.1
27.5
26.7
u/l
0.60
534
5092
5
211
0.23
4.04
1.4
1.4
—
—
—
0
0
5
211
0.23
4.04
1.4
1.4
—
—
—
0
0
47
813
0.54
4.03
2.6
2.6
513.1
566.2
mosm/kgh2o
0.78
36
695
12
33
3.69
3.94
1.6
1.2
1.9
1.9
mmol/l
0.01
12
33
120
854
1.51
3.74
1.4
1.2
7.6
11.0
u/ml
0.29
35
345
26
116
2.30
3.69
1.6
1.3
197.9
335.0
ug/g
2.29
13
64
135
988
1.47
3.66
3.4
3.8
—
—
—
0
0
79
1164
0.63
3.62
4.7
6.5
—
—
—
0
0
23
98
2.40
3.62
1.1
1.1
6.5
6.1
u/ml
0.06
14
44
88
589
1.58
3.61
1.3
1.2
—
—
—
0
0
503
4645
1.55
3.59
4.4
3.5
1.4
1.3
mmol/l
2.62
439
4333
32
158
2.08
3.57
3.5
3.6
0.3
0.3
g/l
0.06
11
66
273
2272
1.37
3.55
3.2
3.9
—
—
—
0
0
13
41
3.22
3.51
2.4
2.5
—
—
—
0
0
8
13
6.22
3.51
2.5
2.0
—
—
—
0
0
21
87
2.47
3.51
1.0
1.3
—
—
—
0
0
12
36
3.38
3.49
1.4
1.2
—
—
—
0
0
526
4923
1.61
3.36
13.8
11.8
139.5
139.7
mmol/l
0.77
508
4789
518
4843
1.56
3.18
4.8
3.9
4.7
4.8
mmol/l
0.18
459
4547
21
92
2.33
3.13
1.0
1.1
0.2
0.8
u/ml
—
7
33
526
4942
1.58
3.07
14.0
12.0
4.0
3.9
mmol/l
0.87
507
4800
55
342
1.67
3.04
1.6
2.5
10.3
10.3
g/l
0.02
47
314
168
1322
1.38
3.00
3.6
3.0
7.2
8.1
mmol/l
1.65
128
1127
5
5
10.07
2.98
1.0
1.0
—
—
—
0
0
6
9
6.72
2.87
1.0
1.1
-1.8
3.8
mmol/l
—
6
9
11
36
3.09
2.82
2.4
2.4
0.6
0.9
nmol/l
—
6
27
65
434
1.56
2.71
18.9
15.6
1.2
1.2
inr
0.09
24
57
57
369
1.60
2.71
2.3
2.3
0.2
0.2
g/l
0.18
51
351
24
119
2.06
2.70
1.1
1.1
0.4
1.8
u/ml
—
8
37
7
15
4.71
2.60
1.3
8.6
—
—
—
0
0
520
4908
1.49
2.59
4.7
4.3
2.8
2.9
mmol/l
0.24
455
4585
142
1117
1.36
2.50
3.9
3.2
50.7
110.1
mg/l
0.50
87
718
106
1380
0.72
2.48
2.4
2.9
—
—
—
0
0
50
321
1.61
2.47
2.5
3.4
4.5
4.6
pmol/l
0.29
42
284
579
5627
2.32
2.45
20.3
16.5
30.3
30.2
pg
1.35
572
5561
579
5627
2.32
2.45
20.3
16.5
90.9
90.4
fl
2.03
572
5562
512
4830
1.44
2.43
4.8
3.9
1.4
1.5
mmol/l
1.77
452
4519
579
5628
2.31
2.43
20.4
16.5
4.5
4.5
e12/l
0.38
571
5502
148
1180
1.34
2.38
4.6
4.0
11.0
8.9
mg/mmol
0.21
89
742
579
5632
2.28
2.35
20.5
16.6
7.2
6.6
e9/l
7.97
570
5500
579
5632
2.28
2.35
20.5
16.6
136.4
136.2
g/l
0.12
572
5565
60
854
0.67
2.30
2.0
2.3
3.7
7.5
e6/l
2.33
49
746
578
5624
2.17
2.25
20.5
16.6
266.3
255.6
e9/l
3.71
570
5504
5
9
5.59
2.21
2.4
3.0
—
—
—
0
0
13
54
2.44
2.21
2.0
2.5
—
—
—
0
0
6
14
4.32
2.15
1.7
1.7
—
—
—
0
0
203
1712
1.28
2.14
4.0
4.6
36.1
36.4
g/l
0.29
173
1609
109
844
1.36
2.12
1.4
1.6
443.8
40612390.8
pmol/l
1.34
87
719
43
278
1.59
2.10
2.2
2.2
—
—
—
0
0
42
270
1.60
2.10
2.4
2.8
70.2
72.2
e9/l
0.19
36
207
42
270
1.60
2.10
1.3
1.7
1.2
1.5
g/l
0.51
34
246
80
590
1.41
2.08
1.6
1.9
—
—
—
0
0
69
497
1.44
2.04
1.3
1.3
—
—
—
0
0
8
26
3.10
2.02
5.1
3.0
—
—
—
0
0
48
324
1.52
1.96
3.1
2.2
1907.4
3713.6
u/l
0.51
17
145
82
1072
0.73
1.94
2.5
3.2
1.0
1.0
kg/l
0.18
22
138
548
5284
1.50
1.83
13.4
10.5
—
—
—
0
0
128
1558
0.77
1.83
1.5
1.6
—
—
—
0
0
45
307
1.50
1.77
3.6
3.8
68.0
74.7
ng/l
0.26
38
271
19
103
1.87
1.73
1.1
1.1
—
—
—
0
0
19
103
1.87
1.73
1.1
1.1
—
—
—
0
0
60
436
1.42
1.72
1.7
1.9
380.6
363.1
nmol/l
0.34
53
403
33
212
1.59
1.69
1.2
1.2
—
—
—
0
0
6
19
3.18
1.66
1.0
1.1
1228.7
1405.8
miu/ml
—
6
19
16
84
1.93
1.61
1.1
1.2
—
—
—
0
0
7
26
2.71
1.58
1.3
2.5
678.9
576.2
e6/l
—
7
21
11
50
2.22
1.57
1.5
2.2
—
—
—
0
0
28
177
1.61
1.54
1.3
1.3
—
—
—
0
0
6
144
0.41
1.53
2.8
8.3
—
—
—
0
0
0
42
0.00
1.53
0.0
3.7
—
—
—
0
0
29
186
1.59
1.51
2.0
2.2
—
—
—
0
0
99
1211
0.78
1.45
1.9
1.6
1.6
1.4
mmol/l
1.53
91
1021
7
28
2.52
1.45
1.1
1.3
—
—
—
0
0
33
221
1.52
1.44
1.7
2.5
—
—
—
0
0
51
683
0.72
1.42
1.7
2.8
2.4
2.4
mmol/l
0.04
41
611
9
177
0.50
1.42
5.8
3.4
23.8
24.0
mmol/l
—
9
163
44
602
0.71
1.40
3.2
2.8
0.9
0.7
ug/l
0.68
24
369
7
29
2.43
1.39
1.0
1.0
—
—
—
0
0
457
4781
0.81
1.37
11.0
11.9
39.7
40.3
%
0.63
287
3755
6
23
2.62
1.37
6.3
3.2
—
—
—
0
0
40
283
1.44
1.35
1.1
1.2
—
—
—
0
0
30
200
1.53
1.35
1.2
1.6
—
—
—
0
0
165
1425
1.22
1.34
2.2
3.2
2.4
2.3
mmol/l
0.08
111
1273
80
641
1.29
1.26
2.2
2.3
14.5
14.4
umol/l
0.05
73
582
38
271
1.43
1.25
1.8
2.2
4.0
7.8
ug/l
1.60
29
241
8
36
2.24
1.24
1.1
1.3
—
—
—
0
0
36
255
1.44
1.23
1.3
1.4
224.0
252.8
miu/ml
0.14
17
131
5
19
2.64
1.22
1.0
1.8
—
—
—
0
0
96
1153
0.80
1.21
4.9
4.4
—
—
—
0
0
0
33
0.00
1.16
0.0
1.4
—
—
—
0
0
15
87
1.74
1.16
1.3
1.7
10987.3
14784.8
e6/l
—
9
69
23
342
0.66
1.16
6.4
4.8
6.7
0.2
%
0.45
13
80
22
143
1.56
1.13
1.6
2.5
—
—
—
0
0
20
127
1.59
1.13
1.6
1.9
3.5
6.2
iu/l
—
8
41
19
292
0.64
1.12
8.4
6.6
—
—
—
0
0
64
507
1.29
1.11
5.3
5.4
1.0
1.0
mmol/l
0.09
54
468
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
10
180
0.55
1.08
4.0
2.3
1.7
1.3
%
—
10
180
13
74
1.77
1.07
2.3
2.5
8.4
8.2
kpa
0.21
13
67
47
359
1.34
1.06
1.4
1.5
—
—
—
0
0
34
246
1.41
1.06
1.5
1.9
—
—
—
0
0
14
82
1.72
1.06
1.1
1.1
32.0
101.9
iu/ml
—
7
19
72
584
1.27
1.05
2.1
2.3
2.4
2.4
g/l
0.02
67
534
7
35
2.01
1.00
1.0
1.2
—
—
—
0
0
7
35
2.01
1.00
1.3
1.1
—
—
—
0
0
60
479
1.28
1.00
1.5
1.4
—
—
—
0
0
125
1082
1.20
0.99
1.6
1.7
0.6
1.0
mg/l
2.03
82
811
75
617
1.25
0.98
1.2
1.2
—
—
—
0
0
37
488
0.74
0.98
1.8
2.8
15.5
8.1
umol/l
0.53
31
413
79
654
1.24
0.98
2.8
3.3
0.8
0.8
mmol/l
0.20
73
619
0
30
0.00
0.97
0.0
4.1
—
—
—
0
0
54
427
1.29
0.97
1.2
1.2
180.3
141.3
iu/ml
0.21
16
169
7
37
1.90
0.94
1.3
1.9
11.0
16.9
ug/l
—
7
37
6
28
2.15
0.91
1.0
1.2
—
—
—
0
0
9
153
0.58
0.89
1.9
3.7
19.1
1624.0
u/ml
—
9
131
253
2336
1.15
0.88
2.7
2.7
167.5
99.5
ug/l
0.59
226
2176
8
43
1.87
0.87
1.6
1.4
1.3
1.0
promille
—
8
32
48
380
1.29
0.87
3.0
4.4
3.7
33.2
ug/l
0.90
36
313
8
44
1.83
0.86
1.0
1.5
—
—
—
0
0
47
372
1.29
0.86
2.3
2.6
1.9
1.8
%
0.55
35
333
35
454
0.76
0.84
1.5
1.5
—
—
—
0
0
6
31
1.94
0.84
1.3
2.0
1090.5
836.8
e6/l
—
6
11
13
201
0.64
0.82
2.9
3.0
—
—
—
0
0
17
114
1.51
0.80
1.5
1.2
431.7
407.9
mg/l
0.20
17
109
18
123
1.48
0.78
1.3
1.2
—
—
—
0
0
63
749
0.82
0.75
3.7
3.2
120.7
506.1
ng/l
1.39
36
504
11
68
1.63
0.72
1.2
1.2
—
—
—
0
0
83
716
1.19
0.71
1.8
1.6
—
—
—
0
0
9
146
0.61
0.70
1.0
1.2
—
—
—
0
0
5
27
1.86
0.68
2.6
1.3
762.0
1715.3
e6/l
—
5
17
20
145
1.39
0.66
2.6
1.5
31.9
40.8
nmol/l
1.39
20
138
6
105
0.57
0.62
4.0
3.8
—
—
—
0
0
16
113
1.43
0.61
2.9
6.2
1.2
1.2
mmol/l
0.19
16
99
0
20
0.00
0.60
0.0
2.5
—
—
—
0
0
0
20
0.00
0.60
0.0
2.5
—
—
—
0
0
36
291
1.25
0.59
1.4
1.9
—
—
—
0
0
7
113
0.61
0.58
1.0
1.4
0.1
0.4
nmol/l
—
7
98
73
834
0.86
0.58
1.9
1.7
—
—
—
0
0
69
599
1.17
0.57
1.5
2.0
28.9
29.3
s
0.20
64
583
5
87
0.57
0.56
7.6
3.6
5.8
4.1
e9/l
—
5
87
8
55
1.46
0.56
1.3
1.0
—
—
—
0
0
114
1030
1.13
0.55
4.0
4.3
1.6
2.2
ug/l
1.17
97
927
6
39
1.54
0.53
1.7
1.1
—
—
—
0
0
9
65
1.39
0.50
2.3
2.6
—
—
—
0
0
13
178
0.72
0.49
1.4
1.9
27.6
21.6
s
—
7
154
7
45
1.56
0.49
1.3
1.3
21.9
22.6
nmol/l
—
7
39
35
417
0.83
0.46
1.5
1.3
—
—
—
0
0
58
657
0.87
0.43
1.3
1.4
—
—
—
0
0
5
31
1.62
0.43
1.2
1.5
—
—
—
0
0
61
539
1.15
0.43
2.1
2.3
23.6
24.9
%
0.23
53
461
6
93
0.64
0.42
1.8
2.5
7.5
7.4
ph
—
6
79
12
87
1.39
0.42
1.2
1.3
—
—
—
0
0
6
94
0.63
0.42
1.8
1.8
—
—
—
0
0
5
32
1.57
0.42
1.0
1.3
—
—
—
0
0
5
33
1.52
0.41
1.2
1.0
—
—
—
0
0
5
33
1.52
0.41
2.4
1.5
27.4
30.8
g/l
—
5
26
0
17
0.00
0.40
0.0
2.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
25
205
1.23
0.40
2.7
4.6
—
—
—
0
0
10
71
1.42
0.39
1.5
1.8
—
—
—
0
0
9
66
1.37
0.38
1.6
1.8
—
—
—
0
0
5
77
0.65
0.36
3.2
2.4
—
—
—
0
0
5
78
0.64
0.36
6.8
2.9
8.0
7.5
mmol/l
—
5
78
6
42
1.43
0.35
3.2
2.8
—
—
—
0
0
37
320
1.17
0.35
1.4
1.8
—
—
—
0
0
27
228
1.19
0.34
2.3
2.3
—
—
—
0
0
6
90
0.66
0.33
6.8
3.8
60.8
56.3
%
—
6
90
6
90
0.66
0.33
1.2
1.1
—
—
—
0
0
28
327
0.85
0.32
4.4
3.4
2.4
1.9
mmol/l
0.28
20
257
37
323
1.16
0.32
1.4
1.8
—
—
—
0
0
36
318
1.14
0.28
1.4
1.8
—
—
—
0
0
19
224
0.84
0.26
1.4
2.5
0.2
0.2
e6/l
0.07
19
217
32
283
1.14
0.25
2.3
2.9
67.6
67.0
g/l
0.15
27
262
129
1355
0.94
0.24
2.1
2.0
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
10
125
0.80
0.23
2.8
4.0
—
—
—
0
0
31
346
0.89
0.22
5.5
4.4
0.5
0.5
%
0.06
15
78
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.4
—
46.6
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
12
145
0.82
0.21
3.1
4.6
1.0
0.9
%
0.39
12
135
5
43
1.16
0.21
1.2
1.6
—
—
—
0
0
73
686
1.07
0.20
1.5
1.4
—
—
—
0
0
26
291
0.89
0.19
2.6
2.7
23.0
52.0
u/ml
1.04
26
276
11
132
0.83
0.18
1.2
1.3
—
—
—
0
0
7
60
1.17
0.18
1.0
1.3
—
—
—
0
0
6
77
0.78
0.15
1.3
1.1
—
—
—
0
0
6
78
0.77
0.15
1.2
1.2
—
—
—
0
0
6
78
0.77
0.15
3.7
6.5
105.7
105.6
mmol/l
—
6
69
6
78
0.77
0.15
3.7
6.5
10.7
11.2
mmol/l
—
6
69
34
369
0.92
0.15
5.1
4.8
0.6
0.9
%
0.68
20
102
10
84
1.19
0.14
1.0
4.1
—
—
—
0
0
16
180
0.89
0.13
5.9
8.4
—
—
—
0
0
9
106
0.85
0.13
1.3
1.3
—
—
—
0
0
16
142
1.13
0.12
1.1
1.1
—
—
—
0
0
37
394
0.94
0.11
5.1
6.2
0.1
0.8
mmol/l
0.25
28
301
38
359
1.06
0.10
1.5
1.6
—
—
—
0
0
5
44
1.14
0.10
1.2
1.8
0.8
1.0
g/l
—
5
44
10
87
1.15
0.09
1.1
1.1
—
—
—
0
0
5
48
1.04
0.09
4.6
4.8
14.6
10.7
mg/l
—
5
43
12
134
0.89
0.09
2.3
2.3
—
—
—
0
0
125
1279
0.97
0.08
2.6
2.5
—
—
—
0
0
5
60
0.83
0.08
1.0
1.3
—
—
—
0
0
33
348
0.95
0.08
5.2
4.9
0.0
0.1
%
2.72
18
92
7
81
0.86
0.07
1.9
2.5
—
—
—
0
0
7
82
0.85
0.07
1.4
1.6
—
—
—
0
0
28
266
1.06
0.06
1.3
1.6
319.0
293.5
mu/l
0.16
28
238
33
318
1.04
0.04
3.2
3.1
—
—
—
0
0
11
101
1.09
0.04
1.7
2.3
99.2
74.4
ug/min
—
6
60
10
109
0.92
0.04
1.3
1.3
—
—
—
0
0
11
118
0.93
0.03
1.5
1.1
—
—
—
0
0
19
184
1.03
0.00
6.6
7.4
23.5
24.1
mmol/l
0.19
19
174
24
234
1.03
0.00
1.2
1.1
—
—
—
0
0
64
634
1.01
0.00
1.5
1.9
—
—
—
0
0
24
237
1.01
0.00
1.0
1.1
—
—
—
0
0
109
1092
1.00
0.00
1.7
1.7
—
—
—
0
0
32
319
1.00
0.00
1.4
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
6.6
—
25.9
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
12.5
—
—
—
0
0
6
66
0.91
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
15.6
—
0
7
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
1.0
1.4
0.5
0.5
nmol/l
—
6
57
0
7
0.00
0.00
0.0
8.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_DYSHIDROSIS and mortality.

Females

Parameter HR [95% CI] p-value
L12_DYSHIDROSIS 1.254 [0.92, 1.71] 0.15
Birth year 0.999 [0.99, 1.01] 0.788

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 1569 females with L12_DYSHIDROSIS died.

Males

Parameter HR [95% CI] p-value
L12_DYSHIDROSIS 1.603 [1.25, 2.06] < 0.001
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 941 males with L12_DYSHIDROSIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_DYSHIDROSIS.

N-year risk Females Males
1 0.106% 0.215%
5 0.884% 1.593%
10 2.169% 4.084%
15 3.959% 7.696%
20 7.136% 13.227%

Relationships between endpoints

Index endpoint: L12_DYSHIDROSIS – Dyshidrosis [pompholyx]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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