Drug-induced osteoporosis with pathological fracture

OSTPOPATFRACTURE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M80.4#
  • Cause of death: ICD-10 M80.4#

2 out of 7 registries used, show all original rules.

506

4. Check minimum number of events

None

506

5. Include endpoints

None

506

6. Filter based on genotype QC (FinnGen only)

506

Control definitions (FinnGen only)

Control exclude
OSTEOPOROSIS_FRACTURE_FG

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80
Name in latin
Osteoporosis e medicamento cum fractura pathologica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2573 1758 796
Only index persons 2250 1568 682
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 70.33 71.59 67.62
Only index persons 70.23 71.36 67.63

-FinnGen-

Key figures

All Female Male
Number of individuals 506 352 154
Unadjusted period prevalence (%) 0.10 0.12 0.07
Median age at first event (years) 68.37 68.27 68.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
442
Matched controls
4418
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
+∞
323.0
442
*
318
Kela drug reimbursment
Teriparatide
557.3
184.3
171
5
H05AA02
ATC
teriparatide; parenteral
484.6
167.3
157
5
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
18.6
136.8
389
1251
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
20.9
127.8
205
175
M05BX04
ATC
denosumab; parenteral
23.0
119.6
182
130
H02AB06
ATC
prednisolone; systemic
11.6
101.1
379
1504
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
12.7
96.9
196
261
M05BA04
ATC
alendronic acid; oral
12.2
94.7
196
271
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
32.7
86.5
115
47
L04AX01
ATC
azathioprine; systemic
20.3
80.5
125
84
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
31.2
77.5
104
43
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
9.1
74.1
181
314
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
9.8
67.6
152
224
P01BA02
ATC
hydroxychloroquine; oral
9.6
63.2
143
210
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
50.3
60.1
72
17
N02AA05
ATC
oxycodone; systemic
7.0
58.3
170
363
M81.9
ICD-10 Finland
Osteoporosis, unspecified
12.0
56.6
110
119
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
16.3
54.7
91
69
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.8
54.5
161
345
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
53.7
324
1549
H02AB07
ATC
prednisone; oral
5.7
49.1
170
436
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
14.8
48.0
83
68
M81.4
ICD-10 Finland
Drug-induced osteoporosis
68.0
47.5
54
9
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
47.1
202
652
L95
ICPC
Osteoporosis
12.8
47.0
87
83
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
9.5
46.9
103
137
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.3
46.3
103
140
C03CA01
ATC
furosemide; systemic
4.4
45.9
238
920
H02AB09
ATC
hydrocortisone; systemic
27.0
45.6
63
27
N02AX02
ATC
tramadol; systemic, rectal
4.2
43.6
291
1396
J01MA12
ATC
levofloxacin; systemic
4.8
42.8
177
538
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.6
41.9
106
175
L04AA06
ATC
mycophenolic acid; systemic
23.7
41.8
60
29
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.6
41.3
89
113
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
4.0
40.4
239
1004
M05BA07
ATC
risedronic acid; oral
11.0
39.7
79
86
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.8
39.7
162
479
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
10.4
39.1
80
92
H02AB04
ATC
methylprednisolone; systemic
4.9
38.6
149
414
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
37.5
229
971
ZX120
NOMESCO Finland
Intravenous
6.0
36.3
111
234
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
35.4
173
597
R50.9
ICD-10 Finland
Fever, unspecified
4.8
33.4
127
340
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
177.8
32.1
33
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.5
31.7
131
379
M54.5
ICD-10 Finland
Low back pain
3.4
31.4
217
974
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
31.1
123
340
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.9
30.1
109
274
L04AA13
ATC
leflunomide; oral
13.2
29.8
53
45
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.6
29.8
94
202
A02BC02
ATC
pantoprazole; systemic
3.7
29.6
358
2377
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
61.1
29.6
34
6
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.2
29.4
244
1231
J45.9
ICD-10 Finland
Asthma, unspecified
3.9
29.2
145
493
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.3
28.7
82
155
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.1
28.1
126
389
N03AX16
ATC
pregabalin; oral
3.4
27.5
175
719
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
11.9
27.3
51
48
R03BB04
ATC
tiotropium bromide; inhalant
5.1
27.1
94
224
X59
ICD-10 Finland
Exposure to unspecified factor
3.8
27.0
137
470
A07EC01
ATC
sulfasalazine; oral, rectal
5.4
26.7
87
193
ZXD05
NOMESCO Finland
Urgent procedure
3.1
26.2
192
867
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.6
25.8
144
529
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.8
25.4
93
233
M05BB03
ATC
alendronic acid and colecalciferol; oral
9.2
25.2
54
66
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
9.2
25.2
54
66
L88
ICPC
Rheumatoid/seropositive arthritis
7.4
25.2
62
95
J01FF01
ATC
clindamycin; systemic
3.1
25.0
183
816
L04AD01
ATC
ciclosporin; systemic
14.4
24.8
42
32
SPAT1254
SPAT
Administration of medicine
3.7
24.7
129
447
127
Kela drug reimbursment
Transplant complication
17.0
24.6
39
25
J45.0
ICD-10 Finland
Predominantly allergic asthma
5.1
24.5
83
191
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.3
24.5
49
53
L03
ICPC
Low back symptom/complaint
3.2
24.5
171
737
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
13.9
24.4
42
33
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.4
24.4
97
264
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.7
24.1
64
109
L28
ICPC
Limited function/disability (L)
3.5
24.0
135
495
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.1
24.0
104
307
A46
ICD-10 Finland
Erysipelas
3.9
23.9
111
348
J01MA14
ATC
moxifloxacin; systemic
4.8
23.9
87
216
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.9
23.9
113
360
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.2
23.7
79
178
NF1AA
NOMESCO Finland
Hip X-ray examination
4.4
23.5
94
257
XG410
NOMESCO Finland
Flow-volume spirometry
8.1
23.3
54
75
B01AB05
ATC
enoxaparin; parenteral
2.9
23.1
206
1033
A28
ICPC
Limited function/disability NOS
3.4
23.0
132
490
SPAT1216
SPAT
Assessment of functional ability
3.4
22.9
130
478
J45.1
ICD-10 Finland
Nonallergic asthma
5.3
22.8
74
162
TGC00
NOMESCO Finland
Bronchial lavation
12.8
22.5
40
34
UJF32
NOMESCO Finland
Coloscopy
2.9
22.4
182
859
SPAT1255
SPAT
Intravenous administration of medicine
5.6
22.3
68
138
SPAT1229
SPAT
Assessment of need for aid
4.6
22.2
84
216
S97
ICPC
Chronic ulcer skin
5.7
22.1
67
135
J01MA02
ATC
ciprofloxacin; systemic
2.7
22.1
235
1303
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.6
21.6
81
206
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
11.2
21.6
41
40
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.0
21.2
61
115
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
19.0
21.2
32
18
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.3
21.1
129
496
M35.3
ICD-10 Finland
Polymyalgia rheumatica
6.8
21.1
55
91
SPAT1262
SPAT
Handing over of treatment supplies
3.2
21.0
132
518
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.5
20.8
110
379
GD1AD
NOMESCO Finland
Thorax CT examination
7.5
20.7
50
74
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.0
20.6
52
82
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.7
20.6
75
185
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
9.2
20.4
43
51
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
7.5
20.4
49
72
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
20.3
208
1110
A07AA02
ATC
nystatin; oral
4.9
20.1
69
160
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.1
19.6
131
531
M79.6
ICD-10 Finland
Pain in limb
2.6
19.6
210
1141
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.9
19.5
147
647
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.7
19.5
58
114
H26.3
ICD-10 Finland
Drug-induced cataract
33.0
19.5
25
8
N03AX12
ATC
gabapentin; oral
3.2
19.3
116
437
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
8.0
19.2
44
60
R06.0
ICD-10 Finland
Dyspnoea
2.7
19.0
169
823
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
29.3
18.9
25
9
J01DB01
ATC
cefalexin; oral
3.4
18.9
391
3069
X58
ICD-10 Finland
Exposure to other specified factors
3.6
18.7
95
316
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
18.7
77
214
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.9
18.5
83
249
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
18.4
169
833
A06AD11
ATC
lactulose; oral
3.3
18.4
105
381
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
7.7
18.3
43
61
J46
ICD-10 Finland
Status asthmaticus
7.8
18.0
42
59
A02BC05
ATC
esomeprazole; systemic
2.4
17.9
232
1375
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
17.9
245
1497
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.4
17.7
243
1483
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
17.6
185
978
E0000UV
ATC
NA
2.4
17.6
222
1292
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.7
17.6
31
26
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.1
17.5
49
89
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
9.9
17.5
35
38
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.1
17.4
71
195
L76
ICPC
Fracture: other
7.5
17.3
41
59
Z2446
NOMESCO Finland
Social worker
4.9
17.2
58
131
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
17.2
202
1133
M81.8
ICD-10 Finland
Other osteoporosis
18.3
17.1
26
15
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
18.3
17.1
26
15
ZX108
NOMESCO Finland
Inhalation
18.3
17.1
26
15
SPAT1263
SPAT
Sampling
2.4
16.8
233
1414
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.2
16.8
68
185
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
+∞
16.8
16
*
A41.9
ICD-10 Finland
Sepsis, unspecified
7.1
16.6
41
63
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
11.0
16.5
31
30
M01CB01
ATC
sodium aurothiomalate; parenteral
11.0
16.5
31
30
M48.0
ICD-10 Finland
Spinal stenosis
3.1
16.3
101
385
WX002
NOMESCO Finland
Sedation and analgesia
2.7
16.2
133
607
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.6
16.2
150
734
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
11.4
16.2
30
28
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
25.6
16.2
22
9
WZC30
NOMESCO Finland
Teaching
3.2
15.9
95
351
C07AB07
ATC
bisoprolol; oral
2.3
15.9
262
1713
Z94.4
ICD-10 Finland
Liver transplant status
27.4
15.7
21
8
Z3226
NOMESCO Finland
Physiotherapist
2.7
15.7
124
551
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.4
15.6
58
145
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.8
15.6
45
85
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.2
15.5
61
161
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.4
15.3
182
1007
M05BA06
ATC
ibandronic acid; systemic
7.2
15.3
37
55
J45.8
ICD-10 Finland
Mixed asthma
7.2
15.3
37
55
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.2
15.2
48
101
L04AA01
ATC
[U] ciclosporin; systemic
10.0
15.2
30
32
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.7
15.2
69
208
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.9
15.1
50
111
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
15.0
132
622
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.1
15.0
94
358
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
4.5
14.9
54
132
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
58.7
14.9
17
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.1
14.9
91
343
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
14.8
14.7
24
17
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
14.7
248
1613
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
16.1
14.6
23
15
M13.9
ICD-10 Finland
Arthritis, unspecified
4.3
14.5
55
140
JJC00
NOMESCO Finland
Allogenic transplantation of liver
37.4
14.5
18
5
AA1AD
NOMESCO Finland
CT of head and brain
2.4
14.5
155
806
M05BA01
ATC
etidronic acid; systemic
17.7
14.4
22
13
D64.9
ICD-10 Finland
Anaemia, unspecified
3.4
14.4
75
252
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.7
14.3
109
470
R03DA04
ATC
theophylline; systemic, rectal
4.6
14.3
50
118
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
6.2
14.1
38
66
C03DA01
ATC
spironolactone; oral
3.2
14.1
79
280
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.1
14.1
57
155
S22.3
ICD-10 Finland
Fracture of rib
4.1
14.0
56
150
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
5.6
14.0
41
79
WX892
NOMESCO Finland
Monitored bed care
4.0
14.0
57
156
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.0
14.0
57
156
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.9
13.9
46
102
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.3
13.9
76
263
A07AA09
ATC
vancomycin; oral
14.2
13.9
23
17
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
7.6
13.8
32
45
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
5.5
13.7
41
81
R03AC02
ATC
salbutamol; inhalant
2.2
13.7
261
1765
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.9
13.7
31
42
A05AA02
ATC
ursodeoxycholic acid; oral
11.4
13.7
25
23
A02BA02
ATC
ranitidine; systemic
2.5
13.6
124
590
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
13.6
106
464
B01AA03
ATC
warfarin; systemic
2.5
13.6
124
592
N02BE01
ATC
paracetamol; systemic, rectal
3.2
13.6
404
3403
R03AC03
ATC
terbutaline; inhalant
2.9
13.5
90
355
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.5
13.5
49
120
M25.5
ICD-10 Finland
Pain in joint
2.3
13.5
151
802
Z3231
NOMESCO Finland
Registered nurse
2.3
13.5
156
841
M80.5
ICD-10 Finland
Idiopathic osteoporosis with pathological fracture
22.0
13.4
19
9
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.5
13.4
40
79
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
13.4
61
184
NF3AA
NOMESCO Finland
Femur X-ray examination
8.3
13.3
29
37
R03BA05
ATC
fluticasone; inhalant
2.6
13.3
112
513
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.6
13.2
111
505
J01FA06
ATC
roxithromycin; oral
2.1
13.2
214
1343
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.2
13.2
51
133
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.3
13.1
31
45
L89
ICD-10 Finland
Decubitus ulcer and pressure area
13.5
13.0
22
17
L04AB01
ATC
etanercept; parenteral
13.5
13.0
22
17
S18
ICPC
Laceration/cut
2.1
13.0
226
1459
ZXE00
NOMESCO Finland
One hour or less
2.1
13.0
205
1269
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.4
13.0
47
115
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.2
12.9
31
46
A07EC02
ATC
mesalazine; oral, rectal
4.9
12.9
42
92
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
12.9
243
1622
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.2
12.8
50
131
M54.6
ICD-10 Finland
Pain in thoracic spine
3.9
12.8
54
152
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.8
12.8
88
356
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.8
12.8
88
356
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
12.8
101
443
L29
ICPC
Musculoskeletal sympt/complt other
3.8
12.8
55
158
R03BB01
ATC
ipratropium bromide; inhalant
4.9
12.7
42
93
W19
ICD-10 Finland
Unspecified fall
3.4
12.7
65
215
A07EA06
ATC
budesonide; oral, local oral
5.9
12.7
35
63
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
9.1
12.7
26
30
M80
ICD-10 Finland
Osteoporosis with pathological fracture
11.5
12.7
23
21
R60.0
ICD-10 Finland
Localized oedema
2.9
12.7
82
317
R4110
NOMESCO Finland
Physiotherapy
2.3
12.7
151
821
PAW37
NOMESCO Finland
Biopsy of temporal artery
33.1
12.6
16
5
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.8
12.6
42
94
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
12.6
69
238
WX872
NOMESCO Finland
Intensive care
5.2
12.5
39
81
JN4BD
NOMESCO Finland
Extensive body CT
2.9
12.4
82
323
R03AC13
ATC
formoterol; inhalant
4.3
12.4
47
120
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.7
12.4
42
96
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
12.4
68
235
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.6
12.3
57
174
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.3
12.3
46
116
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
12.3
81
318
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
16.5
12.2
19
12
M05BX03
ATC
strontium ranelate; oral
16.5
12.2
19
12
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
12.9
12.2
21
17
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
7.6
12.2
28
39
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
7.6
12.2
28
39
TQW40
NOMESCO Finland
Remowal of suture of skin
3.6
12.1
57
176
L04AB04
ATC
adalimumab; parenteral
10.5
12.1
23
23
R03AC12
ATC
salmeterol; inhalant
4.5
12.1
43
103
L01BB02
ATC
mercaptopurine; oral
27.6
12.1
16
6
XW000
NOMESCO Finland
Bone marrow biopsy
4.8
12.1
40
89
N06AX21
ATC
duloxetine; oral
3.0
12.1
72
265
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
6.5
12.0
31
51
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.6
12.0
42
99
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.4
12.0
28
40
ZXA00
NOMESCO Finland
Right side
2.2
12.0
160
911
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
12.0
155
869
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
11.8
122
615
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.8
11.8
39
87
SAA03
NOMESCO Finland
Extended examination of mouth
2.1
11.8
180
1088
J96.1
ICD-10 Finland
Chronic respiratory failure
7.5
11.7
27
38
5BA08
NOMESCO Finland
NA
19.6
11.7
17
9
WX110
NOMESCO Finland
Local anesthesy
2.1
11.6
310
2339
SAA02
NOMESCO Finland
Basic examination of mouth
2.0
11.6
277
1997
XF600
NOMESCO Finland
Bloodpressure measurement
3.9
11.5
48
134
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
11.5
70
261
P01AB01
ATC
metronidazole; oral, rectal
2.0
11.5
199
1262
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
123.0
11.5
12
*
TQW99
NOMESCO Finland
Other minor procedure on skin
4.2
11.5
44
114
NH3EA
NOMESCO Finland
Feet X-ray examination with load
7.6
11.4
26
36
WW500
NOMESCO Finland
Blood transfusion
4.9
11.4
37
81
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
11.3
198
1257
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
11.2
178
1086
K83.0
ICD-10 Finland
Cholangitis
13.2
11.2
19
15
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
8.4
11.2
24
30
WX882
NOMESCO Finland
High dependency care
7.4
11.2
26
37
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.4
11.2
56
182
J47
ICD-10 Finland
Bronchiectasis
6.9
11.1
27
41
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
11.1
94
426
R11
ICD-10 Finland
Nausea and vomiting
3.4
11.1
56
183
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.3
11.0
41
103
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
4.2
11.0
42
108
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
5.5
11.0
32
62
SPAT1231
SPAT
Assessment of adjustments needed in living environment
6.8
11.0
27
42
WW200
NOMESCO Finland
Immunization
6.4
10.9
28
46
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
5.9
10.9
30
54
N06AA09
ATC
amitriptyline; systemic
2.8
10.9
76
308
K50.9
ICD-10 Finland
Crohn disease, unspecified
10.0
10.9
21
22
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.3
10.8
40
100
R03DC03
ATC
montelukast; oral
2.5
10.8
95
440
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
3.7
10.7
47
137
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.7
10.7
36
82
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.8
10.7
26
40
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
10.6
115
590
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
10.5
93
430
SPAT1211
SPAT
Application of soft bandage
3.0
10.5
63
231
N05CF01
ATC
zopiclone; oral
2.0
10.4
178
1110
K02.1
ICD-10 Finland
Caries of dentine
1.9
10.4
243
1707
K08.3
ICD-10 Finland
Retained dental root
3.6
10.4
47
141
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.9
10.4
20
21
R03BA02
ATC
budesonide; inhalant
2.4
10.4
99
478
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.0
10.3
41
110
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
6.2
10.3
27
46
R03DC01
ATC
zafirlukast; oral
8.2
10.2
22
28
TQW11
NOMESCO Finland
Vacuum treatment of wound
6.7
10.2
25
39
JN3AD
NOMESCO Finland
Abdominal CT examination
3.2
10.1
53
178
K50.1
ICD-10 Finland
Crohn disease of large intestine
11.7
10.1
18
16
L02
ICPC
Back symptom/complaint
3.1
10.1
57
201
SPAT1325
SPAT
Vaccination
2.0
10.1
188
1207
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.1
10.1
39
102
R4120
NOMESCO Finland
Occupational therapy
3.6
10.1
46
139
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
41.0
10.0
12
*
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
5.9
10.0
27
48
JN4AD
NOMESCO Finland
Body CT examination
3.2
9.9
53
181
A01AB09
ATC
miconazole; local oral
2.8
9.9
65
254
R03AK08
ATC
formoterol and beclometasone; inhalant
4.8
9.9
32
70
R60.9
ICD-10 Finland
Oedema, unspecified
3.9
9.9
40
109
J20
ICD-10 Finland
Acute bronchitis
3.1
9.9
56
199
UJF92
NOMESCO Finland
Capsular endoscopy
7.7
9.8
22
30
J05AB11
ATC
valaciclovir; oral
2.5
9.7
79
351
WX725
NOMESCO Finland
Noninvasive ventilation
4.2
9.7
36
91
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
10.4
9.6
18
18
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.0
9.5
37
98
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.1
9.4
122
674
R01AD08
ATC
fluticasone; nasal
2.0
9.4
137
795
R52.9
ICD-10 Finland
Pain, unspecified
2.9
9.4
59
224
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.9
9.4
187
1220
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.3
9.4
28
56
M70.2
ICD-10 Finland
Olecranon bursitis
5.7
9.4
26
48
UKC02
NOMESCO Finland
Cystoscopy
2.3
9.3
90
436
A02BC01
ATC
omeprazole; systemic
2.0
9.2
142
842
SPAT1234
SPAT
Support of social functional capacity
3.5
9.2
42
127
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
5.6
9.2
26
49
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
9.2
46
150
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
11.8
9.1
16
14
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.3
9.1
27
54
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
4.4
9.1
32
77
R03AK07
ATC
formoterol and budesonide; inhalant
2.2
9.1
97
492
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.1
9.0
50
174
WZA90
NOMESCO Finland
Other doctors statement
2.1
9.0
115
630
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
5.2
9.0
27
55
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
12.9
8.9
15
12
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
8.9
8.9
18
21
Z01.2
ICD-10 Finland
Dental examination
1.9
8.8
183
1207
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.8
8.8
228
1620
X50
ICD-10 Finland
Overexertion and strenuous or repetitive movements
7.4
8.8
20
28
SAA04
NOMESCO Finland
Special inverstigation of mouth
3.7
8.8
38
110
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
8.8
49
171
R53
ICD-10 Finland
Malaise and fatigue
2.1
8.8
105
560
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
51.0
8.7
10
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
8.5
8.7
18
22
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.2
8.6
46
157
R1250
NOMESCO Finland
Evaluation of functional capability
7.2
8.6
20
29
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
8.6
82
393
A02BC03
ATC
lansoprazole; oral
1.9
8.6
158
994
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
11.9
8.6
15
13
R06AE07
ATC
cetirizine; oral
1.8
8.6
199
1359
RS220
NOMESCO Finland
NA
9.3
8.6
17
19
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
10.3
8.6
16
16
49300
ICD-8 Finland
Asthma, bronchiale
5.6
8.6
24
45
Z2221
NOMESCO Finland
Medical doctor
2.0
8.6
140
845
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.4
8.6
40
124
N05BA01
ATC
diazepam; systemic, rectal
2.4
8.6
79
373
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
8.5
150
930
J02AC01
ATC
fluconazole; systemic
1.8
8.5
193
1308
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.9
8.5
53
201
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
5.2
8.5
25
50
A01
ICPC
Pain general/multiple sites
2.8
8.4
53
202
ZZH31
NOMESCO Finland
Bone allograft, small pieces
13.1
8.4
14
11
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.8
8.4
235
1705
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
8.4
40
126
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.4
8.4
29
69
E23.03
ICD-10 Finland
Lack of ACTH
+∞
8.4
8
*
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
11.0
8.3
15
14
N03AX09
ATC
lamotrigine; oral
4.7
8.3
27
60
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
8.3
72
327
EBA10
NOMESCO Finland
Surgical removal of tooth
2.7
8.3
56
223
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.5
8.3
28
65
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.8
8.3
52
198
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
8.3
52
198
WX290
NOMESCO Finland
Other blockade of nerve
1.9
8.3
172
1130
NG4AA
NOMESCO Finland
Lower leg X-ray examination
5.6
8.3
23
43
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.4
8.3
29
70
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
14.8
8.2
13
9
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
14.8
8.2
13
9
J01DA01
ATC
[U] cefalexin; systemic
1.8
8.2
286
2219
H25.8
ICD-10 Finland
Other senile cataract
2.4
8.2
70
318
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.2
8.1
30
76
A11CC03
ATC
alfacalcidol; systemic
6.5
8.1
20
32
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
8.1
83
413
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
8.0
114
649
J01AA02
ATC
doxycycline; systemic
1.9
8.0
351
2936
TK800
NOMESCO Finland
Hemodialysis
5.3
8.0
23
45
ZX112
NOMESCO Finland
Subcutaneous
5.9
7.9
21
37
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
13.3
7.9
13
10
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
5.0
7.9
24
50
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
5.0
7.9
24
50
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
7.9
45
161
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
7.8
60
257
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
9.7
7.8
15
16
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
2.8
7.8
52
203
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
7.8
89
463
K50.0
ICD-10 Finland
Crohn disease of small intestine
7.6
7.7
17
23
ZXA05
NOMESCO Finland
Left side
1.9
7.7
141
879
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.7
7.7
25
56
ZZA00
NOMESCO Finland
Split skin graft
4.7
7.7
25
56
B02.9
ICD-10 Finland
Zoster without complication
3.2
7.7
40
135
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.9
7.7
123
734
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.3
7.7
71
335
N30.0
ICD-10 Finland
Acute cystitis
2.2
7.7
84
429
S32.7
ICD-10 Finland
Multiple fractures of lumbar spine and pelvis
8.3
7.7
16
20
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
5.3
7.7
22
43
M54.4
ICD-10 Finland
Lumbago with sciatica
2.1
7.6
90
475
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
18.7
7.6
11
6
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
5.6
7.6
21
39
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.0
7.6
43
152
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
25.5
7.6
10
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
25.5
7.6
10
*
J01DA06
ATC
[U] cefuroxime; systemic
2.2
7.6
79
392
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.9
7.5
45
167
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
4.7
7.5
24
53
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
7.5
79
397
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.5
7.5
21
40
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.5
185
1276
N07BC02
ATC
methadone; systemic
81.4
7.4
8
*
R52.2
ICD-10 Finland
Other chronic pain
4.9
7.4
23
49
R35
ICD-10 Finland
Polyuria
3.2
7.4
38
127
TAB00
NOMESCO Finland
Lumbar puncture
3.9
7.4
29
78
H26.4
ICD-10 Finland
After-cataract
2.4
7.3
62
280
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
7.3
7
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
7.3
7
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.8
7.3
23
50
R51.80
ICD-10 Finland
Headache
2.3
7.3
68
320
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.4
7.2
61
274
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.5
7.2
58
253
-1
NOMESCO Finland
NA
1.8
7.2
143
913
NH1AD
NOMESCO Finland
Ankle and foot CT
5.2
7.2
21
42
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
6.8
7.2
17
26
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
30.5
7.2
9
*
W22
ICD-10 Finland
Striking against or struck by other object(s)
3.4
7.2
33
102
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
3.4
7.2
33
102
B01AB04
ATC
dalteparin; parenteral
3.2
7.1
36
119
C08CA01
ATC
amlodipine; oral
1.8
7.1
181
1253
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.5
7.1
32
97
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.1
7.1
38
131
A06AH03
ATC
naloxegol; oral
12.3
7.1
12
10
L17
ICPC
Foot/toe symptom/complaint
1.9
7.1
132
824
L84
ICD-10 Finland
Corns and callosities
4.1
7.1
26
66
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
7.1
109
638
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
10.3
7.1
13
13
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.7
7.1
207
1496
J01CA04
ATC
amoxicillin; systemic
1.9
7.0
349
2955
A41.8
ICD-10 Finland
Other specified sepsis
7.7
6.9
15
20
SPAT1172
SPAT
Guidance concerning hydration
4.5
6.9
23
53
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.9
6.9
114
682
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.7
6.9
234
1755
A02BA03
ATC
famotidine; systemic
3.7
6.9
29
83
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.1
6.9
87
471
D68.8
ICD-10 Finland
Other specified coagulation defects
14.1
6.9
11
8
M87.9
ICD-10 Finland
Osteonecrosis, unspecified
14.1
6.9
11
8
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.3
6.9
33
105
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
4.3
6.9
24
58
R96
ICPC
Asthma
2.6
6.9
50
205
XG466
NOMESCO Finland
Sleep oxymetry
3.9
6.9
27
73
S92.3
ICD-10 Finland
Fracture of metatarsal bone
3.9
6.9
27
73
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.9
6.9
27
73
XKD00
NOMESCO Finland
Uroflowmetry
2.2
6.9
71
353
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.0
6.9
26
68
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
8.5
6.9
14
17
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.8
6.8
43
163
S81.9
ICD-10 Finland
Open wound of lower leg, part unspecified
11.2
6.8
12
11
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.4
6.8
23
54
SPAT1301
SPAT
No procedures
1.8
6.8
159
1070
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
40.7
6.8
8
*
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
40.7
6.8
8
*
E000006
ATC
NA
2.7
6.8
46
182
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
17.0
6.8
10
6
NA3BA
NOMESCO Finland
Lumbar spine extensive X-ray examination without contrast
17.0
6.8
10
6
K05.18
ICD-10 Finland
Chronic gingivitis
3.2
6.8
33
107
ZXA10
NOMESCO Finland
Bilateral
1.9
6.7
103
600
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
5.1
6.7
20
41
C08CA05
ATC
nifedipine; systemic
2.9
6.7
40
148
B01AB10
ATC
tinzaparin; parenteral
2.6
6.7
47
192
WZA00
NOMESCO Finland
Short statement of of health and health related matters
3.3
6.7
32
102
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
6.7
71
354
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
6.6
6.7
16
25
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.7
6.7
21
46
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
6.7
31
97
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
8.0
6.7
14
18
N06AX16
ATC
venlafaxine; oral
2.2
6.6
65
316
D07AC13
ATC
mometasone; topical
1.8
6.6
131
831
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
4.9
6.6
20
42
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
6.6
116
707
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
12.5
6.6
11
9
A08
ICPC
Swelling
3.1
6.6
35
121
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.6
6.6
21
47
E000003
ATC
NA
3.6
6.5
28
82
S61.9
ICD-10 Finland
Open wound of wrist and hand, part unspecified
6.3
6.5
16
26
K50.8
ICD-10 Finland
Other Crohn disease
6.3
6.5
16
26
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
6.3
6.5
16
26
SPAT1210
SPAT
Application of cast or individual aid
3.5
6.5
29
88
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.8
6.5
20
43
WX320
NOMESCO Finland
Spinalanesthesy
1.9
6.5
115
703
EBA00
NOMESCO Finland
Extraction of tooth
1.8
6.5
137
889
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
7.6
6.5
14
19
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
70.8
6.4
7
*
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
14.6
6.4
10
7
H02AB08
ATC
triamcinolone; systemic
14.6
6.4
10
7
EB1WA
NOMESCO Finland
NA
14.6
6.4
10
7
Y88.1
ICD-10 Finland
Sequelae of misadventures to patients during surgical and medical procedures
14.6
6.4
10
7
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
6.4
138
902
A07DA03
ATC
loperamide; oral
3.7
6.4
26
73
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.3
6.4
59
279
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
6.4
128
818
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
5.3
6.4
18
35
N05BA04
ATC
oxazepam; oral
1.8
6.4
122
768
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.7
6.4
20
44
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.8
6.3
38
142
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
6.3
169
1176
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
11.2
6.3
11
10
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
9.4
6.3
12
13
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.4
6.3
21
49
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.7
6.3
26
74
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
6.3
140
924
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.9
6.3
19
40
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
18.3
6.3
9
5
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.9
6.3
24
64
K03.66
ICD-10 Finland
Tooth plaque
2.8
6.3
38
143
R02
ICPC
Shortness of breath/dyspnoea
2.2
6.3
66
328
RS221
NOMESCO Finland
NA
7.2
6.3
14
20
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
+∞
6.3
6
*
JJ5AT
NOMESCO Finland
NA
27.1
6.2
8
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
27.1
6.2
8
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.3
6.2
29
91
M70.6
ICD-10 Finland
Trochanteric bursitis
2.0
6.2
78
420
J01EA01
ATC
trimethoprim; systemic
1.8
6.2
132
855
WX730
NOMESCO Finland
Conventional respirator
6.4
6.2
15
24
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.2
6.2
30
97
W10
ICD-10 Finland
Fall on and from stairs and steps
3.2
6.2
30
97
N02AC04
ATC
dextropropoxyphene; oral
3.2
6.2
30
97
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
5.9
6.2
16
28
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.2
6.2
22
55
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
6.2
39
148
I50.0
ICD-10 Finland
Congestive heart failure
2.8
6.2
39
148
J05AB01
ATC
aciclovir; systemic
1.9
6.2
102
611
S20.2
ICD-10 Finland
Contusion of thorax
3.5
6.2
27
81
T79.3
ICD-10 Finland
Post-traumatic wound infection, not elsewhere classified
7.8
6.2
13
17
R03BA01
ATC
beclometasone; inhalant
2.0
6.1
77
413
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
6.1
63
311
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
12.7
6.1
10
8
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
12.7
6.1
10
8
NA2AD
NOMESCO Finland
Thoracic spine CT examination
12.7
6.1
10
8
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
12.7
6.1
10
8
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
12.7
6.1
10
8
SPAT1167
SPAT
Insertion of urinary catheter
3.8
6.1
24
66
JN4CD
NOMESCO Finland
Very extensive body CT
3.3
6.1
29
93
Z01.9
ICD-10 Finland
Special examination, unspecified
2.8
6.1
37
140
A07EA02
ATC
hydrocortisone; rectal
5.3
6.1
17
33
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
5.3
6.1
17
33
R01AD09
ATC
mometasone; nasal
1.7
6.0
192
1398
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.3
6.0
28
88
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.9
6.0
35
128

Mortality – FinRegistry

Association

Association between endpoint OSTPOPATFRACTURE and mortality.

Females

Parameter HR [95% CI] p-value
OSTPOPATFRACTURE 2.879 [2.39, 3.46] < 0.001
Birth year 0.996 [0.99, 1.01] 0.421

During the follow-up period (1.1.1998 — 31.12.2019), 572 out of 1455 females with OSTPOPATFRACTURE died.

Males

Parameter HR [95% CI] p-value
OSTPOPATFRACTURE 4.177 [3.06, 5.7] < 0.001
Birth year 0.991 [0.98, 1.0] 0.09

During the follow-up period (1.1.1998 — 31.12.2019), 329 out of 649 males with OSTPOPATFRACTURE died.

Mortality risk

Mortality risk for people of age

years, who have OSTPOPATFRACTURE.

N-year risk Females Males
1 0.297% 0.753%
5 1.672% 4.626%
10 3.99% 12.785%
15 7.552% 23.481%
20 14.115% 37.703%

Relationships between endpoints

Index endpoint: OSTPOPATFRACTURE – Drug-induced osteoporosis with pathological fracture

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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