No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
707 |
4. Check minimum number of eventsNone |
707 |
5. Include endpointsNone |
707 |
6. Filter based on genotype QC (FinnGen only) |
707 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[5-9]|Q7
- Name in latin
- Deformitates congenitae coxae
Similar endpoints
↥List of similar endpoints to
Congenital deformities of hip
based on the number of shared cases.
Similar with more cases:
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17520 | 12354 | 5155 |
| Only index persons | 11084 | 7907 | 3177 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.35 | 0.14 |
| Only index persons | 0.24 | 0.29 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 0.08 | 0.05 | 0.06 |
| Only index persons | 0.13 | 0.10 | 0.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 707 | 574 | 133 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.06 |
| Median age at first event (years) | 24.65 | 26.48 | 16.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 633
- Matched controls
- 6330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q65.0
ICD-10 Finland
Congenital dislocation of hip, unilateral
+∞
257.4
229
*
M16.3
ICD-10 Finland
Other dysplastic coxarthrosis
292.3
120.4
119
5
Q65.1
ICD-10 Finland
Congenital dislocation of hip, bilateral
+∞
109.6
102
*
Q65.80
ICD-10 Finland
Congenital dysplastic hip or acetabulum, unilateral
+∞
101.9
95
*
Q65.88
ICD-10 Finland
Other congenital deformities of hip
+∞
98.6
92
*
NF1AA
NOMESCO Finland
Hip X-ray examination
15.2
92.3
161
139
NEK20
NOMESCO Finland
Fenestration or forage of bone of pelvis
+∞
90.9
85
*
Q65.81
ICD-10 Finland
Congenital dysplastic hip or acetabulum, bilateral
+∞
86.5
81
*
L13
ICPC
Hip symptom/complaint
6.5
61.5
182
372
M16.7
ICD-10 Finland
Other secondary coxarthrosis
165.3
58.0
60
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
9.8
56.0
120
148
NE1AA
NOMESCO Finland
Pelvis X-ray examination
10.4
54.8
113
130
NFF25
NOMESCO Finland
Cleaning of hip joint, arthroscopic
82.4
54.1
60
8
NFB60
NOMESCO Finland
Demanding prosthetic replacement of hip
289.0
53.0
53
*
Q65.3
ICD-10 Finland
Congenital subluxation of hip, unilateral
+∞
52.9
50
*
M16.2
ICD-10 Finland
Coxarthrosis resulting from dysplasia, bilateral
+∞
52.9
50
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
23.2
52.4
76
37
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
13.4
50.8
91
78
NFG00
NOMESCO Finland
Arthroplasty of hip joint
+∞
48.6
46
*
7543A
ICD-9 Finland
Certain congenital musculoskeletal deformities, Congenital dislocation of hip[LUXATIO COXAE CONGENITA]
492.3
46.9
46
*
NFE15
NOMESCO Finland
Plastic repair of capsule or ligament of hip joint
161.1
43.4
45
*
Q65.6
ICD-10 Finland
Unstable hip
+∞
40.0
38
*
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
13.2
39.1
70
59
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
11.5
37.1
71
69
NF1DA
NOMESCO Finland
X-ray of hips
17.6
34.9
55
34
75560
ICD-8 Finland
Other congenital anomalies of limbs, Dislocatio congenita coxae (fixata)
339.9
32.2
32
*
NFL22
NOMESCO Finland
Myotomy or tenotomy of hip or thigh
316.8
30.1
30
*
Q65.2
ICD-10 Finland
Congenital dislocation of hip, unspecified
+∞
28.3
27
*
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
30.1
27.9
37
13
NEK99
NOMESCO Finland
Other operation on bone of pelvis
+∞
25.2
24
*
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
25.6
24.6
34
14
M16.6
ICD-10 Finland
Other secondary coxarthrosis, bilateral
249.0
23.8
24
*
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
11.2
23.2
44
42
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.5
22.7
47
53
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
46.9
22.5
27
6
ZXA00
NOMESCO Finland
Right side
2.8
22.2
165
701
B01AB05
ATC
enoxaparin; parenteral
2.8
21.9
170
739
NE1BA
NOMESCO Finland
Pelvis extensive X-ray examination
24.1
21.4
30
13
ZXA05
NOMESCO Finland
Left side
2.9
21.3
148
600
NFC00
NOMESCO Finland
Exchange of a loose part of prosthesis in hip joint
+∞
20.9
20
*
Q65.9
ICD-10 Finland
Congenital deformity of hip, unspecified
+∞
20.9
20
*
WX130
NOMESCO Finland
Interpleural anesthesia
+∞
20.9
20
*
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
113.8
20.7
22
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
20.5
222
1156
N03AX16
ATC
pregabalin; oral
2.9
20.5
143
578
75561
ICD-8 Finland
Other congenital anomalies of limbs, Praeluxatio congenita coxae (non fixata, fenomeno Ortolani positivo)
+∞
18.8
18
*
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
72.1
18.8
21
*
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
9.0
18.4
39
46
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
8.4
17.3
38
48
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
13.8
17.1
29
22
L28
ICPC
Limited function/disability (L)
3.1
15.7
94
341
B01AF01
ATC
rivaroxaban; oral
4.2
14.9
58
149
9402
FHL
Plastering in the operating room and possible repositioning
+∞
14.6
14
*
7152E
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,LONKKANIVEL]
82.0
14.6
16
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
14.3
215
1262
NF2AT
NOMESCO Finland
Injection to hip joint with ultrasound guidance
20.6
13.9
20
10
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
14.0
13.8
23
17
XX2AT
NOMESCO Finland
Other injection with ultrasound examination
14.0
13.8
23
17
M25.5
ICD-10 Finland
Pain in joint
2.1
13.8
192
1085
Q66.0
ICD-10 Finland
Talipes equinovarus
+∞
13.6
13
*
Q65.82
ICD-10 Finland
Congenital anterversion of the collum femoris
+∞
13.6
13
*
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
9.7
13.6
27
29
M01AH05
ATC
etoricoxib; oral
1.9
13.5
298
2011
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
12.8
179
1012
M24.8
ICD-10 Finland
Other specific joint derangements, not elsewhere classified
15.8
12.7
20
13
M91.2
ICD-10 Finland
Coxa plana
+∞
12.5
12
*
NFA30
NOMESCO Finland
Exploration of hip joint, arthroscopic
132.5
12.5
13
*
B01AX06
ATC
[U] rivaroxaban; oral
8.2
11.9
26
33
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
6.9
11.9
29
44
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.5
11.7
55
168
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
11.6
93
400
Q65.4
ICD-10 Finland
Congenital subluxation of hip, bilateral
+∞
11.5
11
*
NEU20
NOMESCO Finland
Removal of internal fixation device from pelvis
+∞
11.5
11
*
Q65.5
ICD-10 Finland
Congenital subluxation of hip, unspecified
+∞
11.5
11
*
M76.1
ICD-10 Finland
Psoas tendinitis
122.1
11.5
12
*
R4110
NOMESCO Finland
Physiotherapy
2.0
11.2
161
913
71300
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) coxae
44.1
11.0
13
*
M01AH01
ATC
celecoxib; oral (coxibs)
2.5
10.9
92
406
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.5
10.8
51
156
9165
FHL
Removal of osteosynthesis material
7.8
10.8
24
32
WX320
NOMESCO Finland
Spinalanesthesy
2.2
10.5
113
563
9321
FHL
The first reartroplast due to detachment, also includes the treatment of a fracture due to detachment
111.8
10.4
11
*
Q65.8
ICD-10 Finland
Other congenital deformities of hip
+∞
10.4
10
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
10.3
208
1325
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
10.0
144
813
L89
ICPC
Osteoarthrosis of hip
7.6
9.8
22
30
ZXE20
NOMESCO Finland
More than three and less than five hours
2.4
9.7
85
385
9964A
ICD-9 Finland
Complications peculiar to certain specified procedures, Mechanical complication of internal orthopaedic device, implant and graft
101.5
9.4
10
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
9.4
125
681
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.4
9.1
79
355
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
6.7
9.0
22
34
A28
ICPC
Limited function/disability NOS
2.7
8.9
61
242
A02BC05
ATC
esomeprazole; systemic
1.8
8.8
193
1256
SPAT1216
SPAT
Assessment of functional ability
2.4
8.7
76
340
M01AE02
ATC
naproxen; oral, rectal
1.7
8.7
378
2989
S70.0
ICD-10 Finland
Contusion of hip
4.6
8.6
29
66
ZSN00
NOMESCO Finland
Procedure related to previous procedure classified in chapter N
27.9
8.5
11
*
L08
ICPC
Shoulder symptom/complaint
2.2
8.5
95
479
A02BC02
ATC
pantoprazole; systemic
1.7
8.4
288
2126
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
8.4
56
216
9403
FHL
Adductorotomy
+∞
8.3
8
*
TNF31
NOMESCO Finland
Prefabricated orthosis, hip or thigh
+∞
8.3
8
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
4.0
8.2
31
80
S73.1
ICD-10 Finland
Sprain and strain of hip
9.6
7.8
15
16
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
25.3
7.6
10
*
M79.6
ICD-10 Finland
Pain in limb
1.7
7.6
193
1303
M01AB05
ATC
diclofenac; systemic, rectal
1.6
7.4
300
2287
Q65
ICD-10 Finland
Congenital deformities of hip
+∞
7.3
7
*
SPAT1229
SPAT
Assessment of need for aid
3.3
7.3
35
111
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
5.1
7.2
21
42
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.9
207
1454
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.8
456
3901
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
3.2
6.6
32
102
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.6
95
533
NFK99
NOMESCO Finland
Other operation on bone of femur
70.5
6.4
7
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
11.2
6.3
11
10
B01AX05
ATC
fondaparinux; parenteral
18.2
6.3
9
5
Q65.83
ICD-10 Finland
Congenital coxa whale
+∞
6.3
6
*
NFK70
NOMESCO Finland
Bone transport operation of femur
+∞
6.3
6
*
NF1CB
NOMESCO Finland
Hip artrography with X-ray
+∞
6.3
6
*
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
4.2
6.3
22
54
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.7
6.2
40
154
M05BA04
ATC
alendronic acid; oral
3.0
6.2
33
114
M01AB55
ATC
diclofenac, combinations; oral
3.0
6.1
32
109
M03BX02
ATC
tizanidine; oral
1.5
6.1
283
2196
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
6.8
6.1
14
21
M22.0
ICD-10 Finland
Recurrent dislocation of patella
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_DEFORMITI_HIP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_DEFORMITI_HIP | 1.38 [1.15, 1.65] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.083 |
During the follow-up period (1.1.1998 — 31.12.2019), 242 out of 11663 females with Q17_CONGEN_DEFORMITI_HIP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_DEFORMITI_HIP | 1.696 [1.33, 2.16] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.15 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 4808 males with Q17_CONGEN_DEFORMITI_HIP died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_DEFORMITI_HIP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.113% | 0.388% |
| 5 | 0.763% | 2.236% |
| 10 | 1.75% | 5.465% |
| 15 | 3.518% | 10.243% |
| 20 | 6.237% | 17.495% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_DEFORMITI_HIP – Congenital deformities of hip
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data