primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
829 |
4. Check minimum number of eventsNone |
829 |
5. Include endpointsNone |
829 |
6. Filter based on genotype QC (FinnGen only) |
795 |
Control definitions (FinnGen only)
- Control exclude
- AUTOIMMUNE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K74
- Name in latin
- Cirrhosis biliaris [primaria]
Similar endpoints
↥List of similar endpoints to
Primary biliary cholangitis (PBC)
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Diseases of liver
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4570 | 3617 | 916 |
| Only index persons | 3977 | 3212 | 765 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.03 |
| Only index persons | 0.10 | 0.12 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 60.86 | 60.40 | 62.52 |
| Only index persons | 59.55 | 59.08 | 61.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 795 | 653 | 142 |
| Unadjusted period prevalence (%) | 0.20 | 0.23 | 0.07 |
| Median age at first event (years) | 57.85 | 56.67 | 63.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 829
- Matched controls
- 8290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A07EA06
ATC
budesonide; oral, local oral
57.4
308.3
177
39
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
93.4
307.7
329
58
A05AA02
ATC
ursodeoxycholic acid; oral
2392.9
307.7
735
27
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
232.5
307.7
640
119
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
307.7
829
*
L04AX01
ATC
azathioprine; systemic
85.5
267.0
142
20
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
13.2
264.8
311
360
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
104.5
255.2
132
15
K76.9
ICD-10 Finland
Liver disease, unspecified
41.6
230.0
142
41
K83.0
ICD-10 Finland
Cholangitis
31.0
158.5
106
39
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
38.7
149.2
93
27
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
56.8
144.3
82
16
H03AA01
ATC
levothyroxine sodium; systemic
8.6
137.1
204
304
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
16.1
124.2
111
79
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.9
114.5
439
1543
L04AA06
ATC
mycophenolic acid; systemic
44.7
110.4
66
16
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
55.8
108.8
62
12
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
51.5
107.1
62
13
127
Kela drug reimbursment
Transplant complication
37.7
105.6
66
19
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.8
104.4
238
539
L04AD01
ATC
ciclosporin; systemic
37.3
94.2
59
17
A07EC02
ATC
mesalazine; oral, rectal
18.6
92.1
75
44
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.7
87.6
89
78
P01BA02
ATC
hydroxychloroquine; oral
10.2
87.3
104
115
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
320.8
86.4
86
*
C10AC01
ATC
colestyramine; oral
12.7
83.0
84
73
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.6
83.0
150
269
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
81.1
468
2079
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
70.9
67
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
15.1
69.7
63
45
Z94.4
ICD-10 Finland
Liver transplant status
250.5
68.3
69
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.9
68.2
76
76
R94.5
ICD-10 Finland
Abnormal results of liver function studies
19.2
67.7
54
30
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
12.3
66.3
68
60
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
+∞
64.4
61
*
K51.5
ICD-10 Finland
Left sided colitis
632.2
60.5
59
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
10.1
58.8
69
74
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
307.2
57.0
57
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
21.5
56.9
43
21
UJK02
NOMESCO Finland
ERCP
9.8
55.8
67
74
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
203.7
55.7
57
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
203.7
55.7
57
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.5
53.0
80
117
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
7.5
51.2
77
112
UJF32
NOMESCO Finland
Coloscopy
3.1
50.8
308
1326
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
49.7
150
411
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
130.0
46.3
49
*
5716A
ICD-9 Finland
Chronic liver disease and cirrhosis, Biliary cirrhosis[CIRRHOSIS BILIARIS PRIMARIA]
+∞
44.2
42
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
12.1
44.1
45
39
C03DA01
ATC
spironolactone; oral
3.7
43.3
163
519
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
43.1
41
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
10.0
42.8
50
53
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
72.6
42.5
48
7
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
428.0
41.5
41
*
L04AD02
ATC
tacrolimus; systemic
51.5
37.0
44
9
104
Kela drug reimbursment
Thyroid insufficiency
6.7
36.8
60
95
A10AB05
ATC
insulin aspart; parenteral
5.6
36.4
72
138
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
34.6
33
*
C10AB05
ATC
fenofibrate; oral
9.2
33.9
42
48
D97
ICPC
Liver disease NOS
40.1
33.7
42
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
33.4
431
2576
H02AB06
ATC
prednisolone; systemic
2.4
33.3
439
2646
M05BA04
ATC
alendronic acid; oral
3.4
32.6
132
436
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
329.1
32.1
32
*
I73.0
ICD-10 Finland
Raynaud syndrome
9.6
31.1
37
40
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
12.3
30.9
31
26
ZX120
NOMESCO Finland
Intravenous
3.4
29.9
117
378
JJ5AT, ,
NOMESCO Finland
302.1
29.0
29
*
N02AX02
ATC
tramadol; systemic, rectal
2.3
28.5
408
2495
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
28.3
27
*
E03
ICD-10 Finland
Other hypothyroidism
8.5
27.5
36
44
K50.8
ICD-10 Finland
Other Crohn disease
+∞
27.2
26
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
26.7
222
1071
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
26.2
25
*
T89
ICPC
Diabetes insulin dependent
10.0
26.0
30
31
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.7
25.9
63
144
C03CA01
ATC
furosemide; systemic
2.3
25.5
278
1505
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
51.8
25.4
30
6
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
6.7
24.9
40
62
L04AA01
ATC
[U] ciclosporin
35.7
24.4
31
9
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
24.1
23
*
TK800
NOMESCO Finland
Hemodialysis
9.9
23.3
27
28
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
55.7
23.2
27
5
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.5
22.9
58
137
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.4
22.6
89
287
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
8.2
22.3
30
38
JJA20
NOMESCO Finland
Open biopsy of liver
39.8
21.8
27
7
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
225.7
21.7
22
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.0
21.6
27
31
A10AC01
ATC
insulin (human); parenteral
4.2
21.3
59
149
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
20.9
20
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
38.3
20.9
26
7
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.5
20.7
143
627
J01MA02
ATC
ciprofloxacin; systemic
2.0
20.4
345
2171
L01BB02
ATC
mercaptopurine; oral
75.4
19.8
22
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
25.3
19.6
27
11
K90.0
ICD-10 Finland
Coeliac disease
18.7
19.2
29
16
R18
ICD-10 Finland
Ascites
5.4
19.1
38
73
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
35.2
19.0
24
7
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
18.8
18
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
18.8
18
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.5
18.7
66
198
L04AX03
ATC
methotrexate; systemic
4.6
18.4
45
103
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.0
18.3
54
143
H02AB04
ATC
methylprednisolone; systemic
2.4
18.1
142
657
107
Kela drug reimbursment
Pernicious anaemia
+∞
17.8
17
*
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
17.8
17
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
97.2
17.6
19
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
17.5
96
374
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
24.7
17.4
24
10
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.5
17.3
63
193
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
17.2
83
301
J01MA12
ATC
levofloxacin; systemic
2.2
17.2
170
868
A02BC02
ATC
pantoprazole; systemic
2.0
17.1
594
4650
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
17.0
135
628
K74.4
ICD-10 Finland
Secondary biliary cirrhosis
+∞
16.7
16
*
A10AE04
ATC
insulin glargine; parenteral
3.0
16.2
73
255
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.7
16.0
92
366
R50.9
ICD-10 Finland
Fever, unspecified
2.4
16.0
127
590
A07EC01
ATC
sulfasalazine; oral, rectal
4.5
15.8
39
90
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
15.7
15
*
C08CA05
ATC
nifedipine; systemic
3.3
15.7
61
195
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
15.6
207
1177
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.3
15.5
41
100
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.5
15.0
52
154
H02AB07
ATC
prednisone; oral
2.3
15.0
122
572
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.2
14.7
61
203
K50.9
ICD-10 Finland
Crohn disease, unspecified
81.6
14.6
16
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
152.6
14.5
15
*
A07AA11
ATC
rifaximin; oral
36.7
14.5
18
5
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
14.4
197
1128
K74.0
ICD-10 Finland
Hepatic fibrosis
27.7
14.3
19
7
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
14.2
96
414
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.9
14.1
252
1574
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
6.8
14.1
22
33
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
30.6
13.9
18
6
A10AB01
ATC
insulin (human); parenteral
11.7
13.9
25
22
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
13.8
55
178
Z2221
NOMESCO Finland
Medical doctor
1.9
13.8
247
1543
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
34.7
13.5
17
5
WX002
NOMESCO Finland
Sedation and analgesia
2.0
13.5
182
1034
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
142.2
13.5
14
*
A06AD11
ATC
lactulose; oral
2.2
13.5
134
681
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.4
13.5
101
456
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
13.2
44
127
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
13.1
306
2064
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
13.1
227
1401
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
13.0
58
201
E0000UV, ,
ATC
1.7
13.0
341
2377
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
12.8
145
774
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
71.0
12.6
14
*
L04AA05
ATC
[U] tacrolimus
71.0
12.6
14
*
L88
ICPC
Rheumatoid/seropositive arthritis
9.5
12.5
25
27
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
12.5
12
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
12.5
12
*
K75.3
ICD-10 Finland
Granulomatous hepatitis, not elsewhere classified
+∞
12.5
12
*
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
12.5
12
*
6611
FHL
Needle biopsy in the operating room
131.9
12.5
13
*
J01FF01
ATC
clindamycin; systemic
1.8
12.3
226
1417
H02AB09
ATC
hydrocortisone; systemic
5.2
12.3
25
49
TGC00
NOMESCO Finland
Bronchial lavation
4.9
12.2
27
57
A10AE05
ATC
insulin detemir; parenteral
3.9
12.1
36
96
R4190
NOMESCO Finland
Nutritional therapy
3.8
12.1
37
101
A07EA02
ATC
hydrocortisone; rectal
13.6
12.0
20
15
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.6
12.0
39
111
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
47.4
11.9
14
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
14.9
11.8
19
13
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
14.9
11.8
19
13
M81.4
ICD-10 Finland
Drug-induced osteoporosis
65.9
11.6
13
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
65.9
11.6
13
*
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
11.3
11.6
21
19
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
10.2
11.5
22
22
JN4AD
NOMESCO Finland
Body CT examination
2.3
11.5
90
413
K83.1
ICD-10 Finland
Obstruction of bile duct
5.1
11.5
24
48
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
11.5
185
1110
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
11.5
126
663
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
+∞
11.5
11
*
ZXE00
NOMESCO Finland
One hour or less
1.7
11.5
324
2285
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
11.4
45
145
A41.9
ICD-10 Finland
Sepsis, unspecified
3.9
11.4
34
91
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
15.3
11.3
18
12
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.2
11.3
46
151
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.1
11.3
115
588
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
9.8
11.3
22
23
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
11.3
239
1557
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
4.7
11.2
26
57
E10
ICD-10 Finland
Type 1 diabetes mellitus
25.4
11.2
15
6
A10AA01, ,
ATC
20.4
11.2
16
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.6
11.0
36
103
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
10.8
142
796
A10AB04
ATC
insulin lispro; parenteral
9.8
10.8
21
22
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.7
10.8
25
55
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.3
10.7
41
130
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.5
10.7
37
110
K51
ICD-10 Finland
Ulcerative colitis
60.8
10.6
12
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
10.5
99
492
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
10.4
10
*
Z3231
NOMESCO Finland
Registered nurse
1.7
10.4
221
1436
XPX08
NOMESCO Finland
Intraoperative flow measurement
12.2
10.4
18
15
L01BA01
ATC
methotrexate; systemic
33.0
10.3
13
*
M05BX04
ATC
denosumab; parenteral
2.5
10.3
66
277
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
23.7
10.3
14
6
XG410
NOMESCO Finland
Flow-volume spirometry
3.1
10.1
41
135
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.3
9.9
21
26
WX882
NOMESCO Finland
High dependency care
4.3
9.7
25
60
A10AA02, ,
ATC
8.0
9.7
21
27
Z94.0
ICD-10 Finland
Kidney transplant status
15.2
9.5
15
10
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
101.2
9.4
10
*
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
9.4
9
*
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
9.4
9
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
9.4
9
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.5
9.3
32
95
B07.9
ICD-10 Finland
Verruca simplex
3.4
9.3
33
100
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
9.2
375
2853
WX892
NOMESCO Finland
Monitored bed care
2.4
9.1
61
262
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
37.1
9.0
11
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.2
9.0
24
59
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.9
9.0
26
68
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
9.0
32
97
K72.1
ICD-10 Finland
Chronic hepatic failure
24.3
8.9
12
5
57309
ICD-8 Finland
Other diseases of liver, Unspecified
24.3
8.9
12
5
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
24.3
8.9
12
5
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.9
8.9
21
31
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
3.6
8.9
29
83
A46
ICD-10 Finland
Erysipelas
2.0
8.9
106
574
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
8.8
324
2398
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
8.8
81
398
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.7
212
1419
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
8.7
69
319
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
50.5
8.7
10
*
B03BA03
ATC
hydroxocobalamin; parenteral
3.1
8.7
36
120
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
16.5
8.6
13
8
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.4
8.6
31
95
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
20.3
8.5
12
6
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
8.5
91
474
JJC60
NOMESCO Finland
Total excision of transplanted liver
91.0
8.4
9
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
8.4
52
215
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
8.4
86
441
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
8.3
8
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
8.3
8
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
8.3
8
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
8.3
8
*
D07AC01
ATC
betamethasone; topical
1.6
8.3
275
1984
WX872
NOMESCO Finland
Intensive care
2.8
8.2
41
152
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
8.2
144
882
A63.0
ICD-10 Finland
Anogenital (venereal) warts
3.3
8.1
30
93
L40.0
ICD-10 Finland
Psoriasis vulgaris
8.2
8.1
17
21
L04AB04
ATC
adalimumab; parenteral
33.7
8.1
10
*
N02AA05
ATC
oxycodone; systemic
1.8
8.1
142
869
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
8.0
141
862
A10AE06
ATC
insulin degludec; parenteral
4.3
8.0
20
47
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.9
7.9
37
132
A41.8
ICD-10 Finland
Other specified sepsis
4.5
7.9
19
43
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
7.9
102
566
K29.7
ICD-10 Finland
Gastritis, unspecified
2.9
7.8
37
133
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.1
7.8
31
101
A11CC03
ATC
alfacalcidol; systemic
4.2
7.8
20
48
XX9XE
NOMESCO Finland
Other ultrasound examination
15.2
7.7
12
8
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
45.4
7.7
9
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
7.7
44
175
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.8
7.7
39
146
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
7.7
155
985
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
25.3
7.6
10
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.5
7.4
18
28
Z2446
NOMESCO Finland
Social worker
2.3
7.4
55
247
M01CB01
ATC
sodium aurothiomalate; parenteral
80.8
7.4
8
*
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
80.8
7.4
8
*
K92.0
ICD-10 Finland
Haematemesis
3.7
7.3
23
64
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.2
7.3
19
46
H3600, E103,
ICD-10 Finland
+∞
7.3
7
*
391
Kela drug reimbursment
Obeticholic acid
+∞
7.3
7
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
7.3
7
*
B81
ICPC
Anaemia vit B12/folate deficiency
3.5
7.3
25
74
M05BA07
ATC
risedronic acid; oral
2.8
7.3
36
133
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
7.4
7.2
16
22
ZXD05
NOMESCO Finland
Urgent procedure
1.6
7.2
224
1583
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.6
7.2
42
169
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
30.3
7.2
9
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
20.2
7.1
10
5
WX419
NOMESCO Finland
Other general anesthesy
6.7
7.1
17
26
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
7.1
305
2311
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
7.0
38
147
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.0
7.0
71
363
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.2
6.9
27
87
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
13.9
6.9
11
8
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
6.9
104
607
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
3.5
6.9
23
67
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
6.9
151
980
ZX108
NOMESCO Finland
Inhalation
11.0
6.8
12
11
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.8
176
1190
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.7
6.8
18
32
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
40.4
6.8
8
*
P01AB01
ATC
metronidazole; oral, rectal
1.5
6.7
336
2618
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
22.7
6.7
9
*
Z3226
NOMESCO Finland
Physiotherapist
1.7
6.7
147
954
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.1
6.7
27
89
N18.8
ICD-10 Finland
Other chronic renal failure
4.1
6.6
18
45
D07AD01
ATC
clobetasol; topical
1.7
6.6
128
803
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
12.4
6.6
11
9
A07AA02
ATC
nystatin; oral
2.2
6.6
53
247
T86
ICPC
Hypothyroidism/myxoedema
4.2
6.6
17
41
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
6.5
131
829
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
6.9
6.5
15
22
RD210, ,
NOMESCO Finland
5.8
6.5
17
30
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
6.5
57
276
XF600
NOMESCO Finland
Bloodpressure measurement
2.3
6.4
49
223
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
70.4
6.4
7
*
57198
ICD-8 Finland
Cirrhosis of liver, Alia definita, alcoholismo non indicato
70.4
6.4
7
*
J01DB01
ATC
cefalexin; oral
1.6
6.4
649
5789
A02BC03
ATC
lansoprazole; oral
1.5
6.4
231
1683
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
6.4
111
676
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
8.2
6.3
13
16
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
6.3
105
630
5BA08, ,
NOMESCO Finland
11.1
6.3
11
10
57199
ICD-8 Finland
Cirrhosis of liver, Unspecified
+∞
6.3
6
*
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
6.3
6
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
6.3
6
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
6.3
6
*
K74.1
ICD-10 Finland
Hepatic sclerosis
+∞
6.3
6
*
H3603, E103,
ICD-10 Finland
+∞
6.3
6
*
A05AA04
ATC
obeticholic acid; oral
+∞
6.3
6
*
I86.4
ICD-10 Finland
Gastric varices
+∞
6.3
6
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
26.9
6.2
8
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
6.2
72
386
A02BC05
ATC
esomeprazole; systemic
1.5
6.2
325
2546
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.6
6.1
19
53
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.5
6.0
20
58
WW200
NOMESCO Finland
Immunization
3.5
6.0
20
58
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.6
6.0
33
129
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
6.0
57
284
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
461
337
29.56
307.65
3.6
2.4
12.59
10.27
g/l
14.60
429
297
440
266
34.12
307.65
2.5
1.6
2.71
1.41
g/l
9.43
405
235
508
585
20.84
307.65
5.1
1.9
0.21
0.22
g/l
3.02
485
558
418
705
10.94
267.09
1.8
1.2
1488.29
332.44
titre
14.13
164
119
152
33
56.18
264.60
1.6
1.0
—
—
titre
—
0
0
181
99
23.11
234.34
1.4
1.1
—
—
—
0
0
651
2091
10.84
222.19
10.2
2.9
38.58
31.78
u/l
3.45
636
1995
740
2774
16.53
216.23
11.4
3.8
35.31
35.80
g/l
2.14
727
2571
369
696
8.75
207.77
6.9
2.5
7.59
7.49
umol/l
0.04
332
590
132
57
27.35
187.09
1.3
1.0
46.11
53.39
u/l
0.72
121
52
777
3471
20.75
177.96
16.9
5.9
12.37
11.03
umol/l
1.84
771
3284
425
1157
6.49
159.84
1.9
1.3
2.57
2.33
g/l
1.56
355
654
686
2928
8.79
154.97
16.6
14.4
1.11
1.23
inr
4.59
256
776
506
1654
6.29
153.85
11.3
3.5
99.41
93.27
%
5.52
490
1619
332
760
6.62
148.93
2.7
2.2
23.50
22.28
%
0.64
279
658
118
69
19.77
146.40
1.1
1.1
1.52
1.48
g/l
0.40
104
63
646
2744
7.13
141.88
4.2
2.1
78.95
78.80
nmol/l
0.05
623
2437
116
73
18.31
138.73
2.0
1.9
0.56
0.98
g/l
1.07
100
59
342
887
5.86
131.94
2.8
2.2
13.74
13.02
umol/l
0.84
320
823
328
821
5.96
131.65
2.7
2.1
2.44
2.38
g/l
0.96
311
757
83
29
31.69
125.70
1.4
1.0
31.32
15.29
u/l
1.01
74
24
84
34
27.38
120.94
1.8
1.4
5.23
4.08
u/l
0.23
72
26
643
3117
5.74
108.95
10.9
4.2
0.22
0.18
e9/l
4.07
590
2683
638
3087
5.63
107.96
10.6
3.9
1.86
1.90
e9/l
0.41
587
2694
604
2825
5.19
105.98
10.8
3.9
3.35
2.79
%
6.07
584
2596
79
39
22.28
105.05
1.1
1.1
326.09
295.06
mg/l
1.64
67
33
610
2922
5.12
102.43
10.9
4.0
29.20
28.28
%
1.32
590
2707
600
2882
4.92
99.16
10.7
3.9
55.29
56.84
%
2.58
578
2660
641
3306
5.14
94.54
9.5
5.3
1.22
1.22
mmol/l
0.08
549
2820
592
2994
4.42
86.52
9.1
4.7
1.22
1.22
mmol/l
0.36
564
2707
49
11
47.28
83.07
1.9
1.1
9.46
9.05
ug/l
0.11
49
11
657
3660
4.83
81.97
12.8
7.8
3.76
3.97
e9/l
1.36
609
3149
718
4354
5.85
78.12
10.9
2.8
126.89
46.26
u/l
23.53
696
4035
53
22
25.67
75.08
1.1
1.0
—
—
—
0
0
447
2006
3.67
74.56
3.8
2.2
63.47
61.05
u/l
0.35
420
1841
81
79
11.26
74.07
6.9
3.8
1281.18
608.13
iu/ml
—
17
8
96
127
8.42
69.70
1.6
1.1
33.02
2.02
u/ml
0.78
24
12
103
149
7.75
69.27
1.5
1.1
31.34
1.25
u/ml
—
8
6
239
742
4.12
68.26
6.9
4.2
1.05
1.04
mmol/l
0.23
229
679
66
53
13.44
68.24
2.2
2.3
33.77
5.24
umol/l
3.76
59
34
102
149
7.67
67.98
2.3
1.2
—
—
—
0
0
96
132
8.09
67.42
1.6
1.2
7.77
3.22
u/ml
0.47
26
18
347
1413
3.50
65.68
1.5
1.2
0.71
1.14
u/ml
0.72
83
363
346
1439
3.41
62.77
3.3
2.1
3.15
3.03
mg/l
0.32
316
1203
219
675
4.05
62.69
1.9
1.6
1.46
1.40
%
0.77
175
590
86
113
8.38
62.66
1.9
1.1
0.21
0.25
g/l
4.36
81
105
264
928
3.71
62.35
2.7
1.9
30.46
29.22
s
2.75
253
896
513
2717
3.33
61.66
3.9
2.6
124.12
105.80
ug/l
0.95
480
2503
86
116
8.16
61.28
1.4
1.2
—
—
—
0
0
737
4977
5.33
59.33
8.5
3.2
24.66
12.16
mm/h
56.27
714
4562
170
455
4.44
58.62
12.4
6.4
10.25
9.06
mmol/l
1.41
165
429
131
284
5.29
58.40
3.7
3.2
30.18
1064.10
u/ml
1.04
103
248
85
120
7.78
58.19
1.8
1.1
1.20
1.27
g/l
0.97
80
111
66
68
10.46
57.88
1.3
1.3
—
—
—
0
0
60
56
11.47
56.28
2.9
1.4
0.91
0.99
g/l
0.91
60
56
62
63
10.56
54.87
1.3
1.3
379.63
246.91
u/ml
1.16
35
34
80
115
7.59
53.83
1.5
1.1
69.31
23.54
u/ml
—
14
10
193
648
3.58
47.61
2.8
1.3
157.09
84.69
ug/g
3.45
167
479
53
53
10.61
47.34
1.6
1.1
105.33
—
u/ml
—
15
0
57
65
9.34
46.27
1.3
1.4
187.67
124.86
u/ml
—
9
16
65
100
6.97
40.97
1.4
1.1
—
—
—
0
0
176
610
3.39
40.83
3.0
4.6
235.86
253.38
u/l
0.57
167
573
235
1001
2.88
37.90
4.6
2.9
0.80
0.82
mmol/l
2.93
223
942
148
500
3.39
35.46
3.6
2.9
82.90
79.94
ng/l
0.13
134
430
39
38
10.72
35.35
1.1
1.0
—
—
—
0
0
72
144
5.38
34.71
4.1
3.3
29.63
2642.37
u/ml
0.82
63
131
167
620
3.12
34.14
2.6
2.1
1.87
1.75
%
0.64
150
549
144
499
3.28
32.98
2.1
2.0
361.82
388.97
nmol/l
0.74
130
449
191
792
2.83
31.82
3.9
4.1
3.39
25.01
ug/l
1.42
144
645
50
77
6.85
31.40
1.7
1.4
0.06
0.18
iu/ml
—
10
18
551
3767
2.38
30.00
9.3
3.8
6.67
6.53
mmol/l
0.69
525
3509
82
210
4.22
29.23
1.6
1.5
1.25
1.52
g/l
1.64
68
177
159
627
2.90
28.87
3.7
2.1
41.41
35.75
u/l
0.59
150
521
85
233
3.95
27.60
2.3
2.0
46.84
40.27
u/l
1.62
79
209
126
452
3.11
26.97
1.6
2.6
68.41
67.49
g/l
0.49
112
413
111
372
3.29
26.61
1.9
1.5
—
—
—
0
0
29
29
10.33
25.73
1.1
1.1
—
—
—
0
0
29
29
10.33
25.73
1.1
1.1
—
—
—
0
0
38
54
7.33
25.62
2.6
1.2
—
—
—
0
0
29
30
9.98
25.12
1.1
1.1
—
—
—
0
0
29
30
9.98
25.12
1.1
1.1
—
—
—
0
0
29
30
9.98
25.12
1.1
1.1
—
—
—
0
0
287
1612
2.19
23.77
3.6
2.2
1576.03
6802.67
umol/l
2.54
259
1409
292
1697
2.11
21.79
3.9
2.7
0.24
0.45
e6/l
2.45
237
1228
229
1225
2.20
21.03
3.1
2.3
5.73
7.44
e6/l
0.74
209
1078
407
2696
2.00
20.95
2.2
1.9
99.22
97.00
pmol/l
0.35
224
1270
209
1085
2.24
20.62
2.0
1.6
1047.95
1195.57
nmol/l
1.70
168
782
307
1850
2.05
20.53
4.0
2.8
67.58
86.07
e6/l
0.17
252
1357
29
39
7.67
20.47
1.4
1.1
60.27
—
u/ml
—
11
0
264
1514
2.09
20.12
1.7
1.5
18.31
21.29
nmol/l
3.06
242
1264
787
6843
3.96
19.25
29.1
11.6
14.84
23.62
mg/l
23.04
732
5238
123
520
2.60
19.10
5.1
3.5
1.23
1.23
mmol/l
1.14
118
457
362
2388
1.92
18.06
3.1
3.4
2.36
2.37
mmol/l
0.54
326
2106
69
226
3.24
17.03
1.4
1.9
7.83
7.39
g/l
1.36
58
207
69
226
3.24
17.03
1.4
1.9
—
—
—
0
0
69
226
3.24
17.03
1.4
1.9
3.93
3.59
g/l
1.29
58
207
41
93
4.59
17.00
4.1
2.6
54.10
58.88
%
1.18
41
93
65
214
3.21
15.90
1.4
1.9
13.60
9.83
g/l
4.94
55
193
64
210
3.22
15.74
1.5
1.9
3.06
3.00
g/l
0.21
53
191
55
164
3.52
15.73
2.9
2.6
—
—
—
0
0
37
85
4.51
15.10
4.1
2.2
3.36
4.69
e9/l
3.76
37
85
300
1950
1.84
14.99
2.3
2.0
126.47
213.60
u/l
1.64
286
1823
121
566
2.33
14.94
14.6
6.1
95.76
95.82
%
0.03
112
546
182
1003
2.04
14.88
2.2
1.7
—
—
—
0
0
56
178
3.30
14.50
1.3
1.5
302.24
309.71
ug/g
0.09
33
103
146
752
2.14
14.23
13.1
5.2
104.47
104.07
mmol/l
0.45
146
752
434
3187
1.76
14.09
4.2
3.5
0.00
0.01
estimate
0.74
104
568
57
187
3.20
14.03
1.4
1.9
37.38
38.43
g/l
0.57
46
168
68
249
2.89
13.84
1.1
1.0
—
—
—
0
0
559
4431
1.80
13.78
5.9
4.3
13.67
2178.92
e6/l
—
9
59
80
322
2.64
13.60
4.4
3.4
0.83
1.82
mmol/l
1.22
58
255
54
175
3.23
13.56
1.5
2.0
0.04
0.00
g/l
0.49
45
165
26
26
10.29
13.54
1.2
1.1
—
—
—
0
0
42
117
3.73
13.28
1.9
1.3
—
—
—
0
0
435
3238
1.72
13.10
4.2
3.5
0.00
0.01
estimate
0.80
96
512
57
195
3.07
13.08
1.5
2.1
0.83
1.05
g/l
0.16
47
178
178
1015
1.96
13.06
3.2
2.4
4.50
3.45
e6/l
0.39
106
502
433
3221
1.72
13.05
5.6
4.7
0.00
0.00
estimate
0.50
96
523
110
523
2.27
13.02
5.8
2.6
1.56
1.91
mmol/l
0.36
97
441
206
1238
1.88
12.89
4.1
3.3
212.91
284.47
ng/l
0.38
159
942
431
3213
1.71
12.80
3.6
2.4
—
—
—
0
0
112
541
2.24
12.75
14.7
6.3
114.45
119.99
g/l
1.69
105
523
128
659
2.11
12.41
14.0
5.7
0.06
1.02
mmol/l
1.55
103
536
48
153
3.27
12.38
1.3
1.2
—
—
—
0
0
51
170
3.13
12.23
1.5
2.0
0.00
0.00
g/l
-0.00
43
161
251
1627
1.78
12.18
3.2
2.1
—
—
—
0
0
51
171
3.11
12.11
1.5
1.9
0.00
0.00
g/l
-0.00
43
162
182
1073
1.89
11.99
3.1
2.4
2.97
1.24
e6/l
0.43
110
554
132
698
2.06
11.90
2.1
1.6
—
—
—
0
0
24
48
5.12
11.52
1.4
1.2
1691.75
1864.48
e6/l
0.09
16
29
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
47
155
3.15
11.48
2.9
3.8
0.25
0.43
u/ml
3.27
26
90
48
161
3.10
11.40
1.6
3.5
1.35
2.16
ratio
—
7
15
788
7183
2.96
11.29
29.6
13.8
138.92
139.81
mmol/l
15.79
781
6982
266
1789
1.72
11.16
3.6
2.9
2021.16
1139.25
ng/l
1.57
240
1508
625
5263
1.76
10.97
4.6
3.0
14.99
14.58
pmol/l
3.88
583
4726
788
7199
2.91
10.93
29.7
13.9
3.94
3.95
mmol/l
0.64
781
6982
124
661
2.03
10.89
14.4
5.7
11.55
12.76
kpa
2.63
118
639
124
661
2.03
10.89
14.5
5.7
4.88
5.11
kpa
2.25
118
637
130
710
1.99
10.66
2.1
1.6
—
—
—
0
0
48
168
2.97
10.60
1.6
3.5
47.74
77.93
mg/l
0.39
41
142
48
170
2.94
10.39
1.6
3.5
67.47
80.02
mg/l
0.11
41
143
20
40
5.10
9.61
1.3
1.2
4071.25
65880.56
e6/l
—
8
18
200
1300
1.71
9.26
2.7
2.9
2.49
2.46
mmol/l
3.19
170
1147
15
11
13.86
9.20
1.0
1.0
—
—
—
0
0
42
149
2.92
9.08
2.0
1.8
—
—
—
0
0
735
6619
1.97
8.92
25.2
11.4
78.57
79.60
ml/min/173m2
0.58
646
5385
266
1899
1.59
8.39
1.9
1.6
1.43
1.34
mmol/l
1.16
234
1619
78
385
2.13
8.37
2.2
1.7
—
—
—
0
0
177
1142
1.70
8.34
1.4
1.2
49.09
23.43
iu/ml
0.80
55
352
114
649
1.88
8.19
3.3
3.0
—
—
—
0
0
25
69
3.70
8.06
2.1
2.1
33.84
31.93
pg
1.24
25
69
31
99
3.21
8.03
1.4
1.3
—
—
—
0
0
36
127
2.92
7.89
1.6
1.3
—
—
—
0
0
326
2470
1.53
7.75
4.2
3.3
72.88
44.06
ng/l
0.52
220
1637
35
123
2.93
7.72
2.7
2.0
119.17
128.62
g/l
1.24
23
86
19
31
6.25
7.57
2.5
2.2
2014.44
50606.23
e6/l
—
9
22
47
200
2.43
7.17
2.4
1.8
1.01
1.08
ug/l
0.07
40
175
19
35
5.53
6.94
1.6
1.2
—
—
—
0
0
34
125
2.79
6.94
7.3
5.5
105.39
105.74
mmol/l
0.16
28
108
709
6439
1.70
6.68
5.7
3.8
2.06
2.06
mu/l
0.00
668
5830
90
512
1.85
6.47
2.7
2.9
255.06
173.04
ng/l
0.75
81
465
161
1083
1.60
6.31
1.3
1.2
12.00
3.15
u/ml
0.70
51
415
6
0
+∞
6.26
1.2
0.0
—
—
—
0
0
490
4142
1.45
6.21
2.9
2.8
—
—
—
0
0
65
344
1.97
5.82
11.8
6.2
24.08
24.56
mmol/l
0.54
57
324
17
46
3.75
5.66
1.1
1.2
—
—
—
0
0
88
519
1.78
5.63
2.9
2.2
67.10
68.35
ml/min/173m2
0.09
41
201
252
1909
1.46
5.62
4.3
3.4
18.57
6.96
mg/mmol
1.83
161
1117
251
1900
1.46
5.62
3.6
2.8
6.24
6.88
mmol/l
1.67
213
1599
49
237
2.13
5.59
6.0
3.8
1.75
1.57
%
0.52
42
218
239
1797
1.46
5.52
3.6
2.9
658.05
196.58
mg/l
0.61
156
1051
312
2479
1.41
5.30
4.6
3.6
—
—
—
0
0
28
108
2.65
5.27
1.1
1.5
—
—
—
0
0
190
1379
1.49
5.21
1.8
1.6
141026087.87
32187383.97
pmol/l
0.52
156
1134
5
0
+∞
5.21
2.4
0.0
—
—
—
0
0
222
1662
1.46
5.21
4.9
3.7
0.00
0.01
estimate
0.88
99
513
11
16
6.95
4.96
1.0
1.5
—
—
—
0
0
13
24
5.49
4.92
1.2
1.1
—
—
—
0
0
13
24
5.49
4.92
1.2
1.1
—
—
—
0
0
13
26
5.06
4.64
2.5
1.5
—
—
—
0
0
48
248
1.99
4.64
2.5
1.8
—
—
—
0
0
201
1509
1.44
4.58
2.1
1.8
1.89
1.07
mg/l
2.54
163
1166
28
117
2.44
4.52
3.5
2.6
8.89
7.86
kpa
2.00
28
117
12
23
5.28
4.47
1.2
1.3
15.58
29.34
umol/l
0.81
12
23
32
144
2.27
4.39
1.2
1.4
—
—
—
0
0
32
144
2.27
4.39
1.2
1.4
—
—
—
0
0
13
28
4.70
4.38
1.2
1.2
—
—
—
0
0
13
28
4.70
4.38
1.2
1.2
—
—
—
0
0
15
45
3.38
4.34
1.9
1.8
—
—
—
0
0
44
226
2.00
4.33
2.3
1.7
—
—
—
0
0
25
101
2.52
4.33
1.2
1.3
—
—
—
0
0
25
101
2.52
4.33
1.2
1.3
—
—
—
0
0
15
38
4.00
4.31
1.3
1.4
—
—
—
0
0
11
20
5.56
4.30
1.1
1.1
—
—
—
0
0
11
20
5.56
4.30
1.1
1.1
—
—
—
0
0
64
375
1.77
4.22
1.3
1.1
161.81
84.05
iu/ml
0.87
22
124
30
136
2.25
4.06
1.4
1.3
—
—
—
0
0
30
136
2.25
4.06
1.4
1.3
—
—
—
0
0
74
457
1.68
4.06
4.1
2.2
4.39
4.31
kpa
0.13
68
442
65
388
1.73
4.03
1.3
1.2
167.45
142.87
u/ml
0.15
54
354
13
32
4.11
3.91
1.0
1.4
—
—
—
0
0
737
6959
1.53
3.67
5.8
4.3
4.83
4.84
mmol/l
0.10
704
6415
21
85
2.51
3.65
1.7
1.3
—
—
—
0
0
27
124
2.22
3.57
1.6
1.5
—
—
—
0
0
7
9
7.83
3.56
1.1
1.4
—
—
—
0
0
24
105
2.32
3.55
3.5
2.3
15.04
15.70
%
0.41
18
55
710
6664
1.46
3.54
5.0
3.8
1.23
1.26
mmol/l
0.80
673
6058
694
6490
1.43
3.50
6.9
5.2
39.55
39.06
mmol/mol
0.68
664
5979
10
22
4.59
3.43
1.2
1.2
—
—
—
0
0
56
337
1.71
3.41
2.4
3.1
4.44
4.54
pmol/l
0.25
51
303
78
515
1.57
3.31
2.0
2.3
5.40
5.97
ug/l
0.21
63
451
6
7
8.62
3.26
2.0
1.7
—
—
—
0
0
6
7
8.62
3.26
1.2
1.0
101.50
116.29
%
—
6
7
20
84
2.42
3.25
1.0
1.1
—
—
—
0
0
32
164
1.99
3.23
1.3
1.3
—
—
—
0
0
17
66
2.61
3.23
1.2
1.6
—
—
—
0
0
13
40
3.29
3.15
1.2
1.3
0.41
1.30
promille
1.73
13
29
21
92
2.32
3.12
1.2
1.1
—
—
—
0
0
9
20
4.54
3.12
1.0
1.6
—
—
—
0
0
19
80
2.41
3.08
1.5
1.3
—
—
—
0
0
13
41
3.20
3.06
1.1
1.1
—
—
—
0
0
19
81
2.38
3.00
1.2
1.4
—
—
—
0
0
9
21
4.32
3.00
3.6
1.7
697.22
677.29
e6/l
—
9
21
19
82
2.35
2.93
1.5
1.1
3.38
1.44
u/ml
—
8
16
18
76
2.40
2.91
1.6
1.3
—
—
—
0
0
10
27
3.74
2.88
2.5
1.2
4.57
7.26
u/l
—
10
21
18
77
2.37
2.83
1.6
1.3
—
—
—
0
0
10
28
3.60
2.79
1.5
2.6
—
—
—
0
0
18
78
2.34
2.76
1.6
1.3
—
—
—
0
0
18
79
2.31
2.69
1.6
1.3
—
—
—
0
0
18
79
2.31
2.69
1.6
1.3
—
—
—
0
0
726
6914
1.40
2.65
5.6
4.3
1.61
1.56
mmol/l
2.05
691
6336
722
6870
1.39
2.65
5.0
4.5
5.93
5.85
mmol/l
0.82
664
6226
29
156
1.89
2.59
1.1
1.1
—
—
—
0
0
9
25
3.63
2.58
3.4
4.0
4264.00
1292.68
u/ml
—
9
25
18
81
2.25
2.55
1.5
1.1
3.83
6.43
u/ml
—
6
28
5
7
7.18
2.55
1.0
1.7
—
—
—
0
0
6
11
5.49
2.54
1.3
1.0
—
—
—
0
0
16
69
2.34
2.49
1.3
1.2
—
—
—
0
0
16
69
2.34
2.49
1.3
1.2
—
—
—
0
0
9
26
3.49
2.48
1.0
1.6
—
—
—
0
0
9
26
3.49
2.48
1.0
1.6
—
—
—
0
0
9
26
3.49
2.48
1.0
1.6
—
—
—
0
0
16
70
2.31
2.42
1.4
1.2
—
—
—
0
0
741
7102
1.41
2.41
6.1
4.8
2.75
2.85
mmol/l
2.60
705
6518
6
12
5.03
2.40
1.8
3.4
—
—
—
0
0
6
12
5.03
2.40
1.8
3.4
—
—
—
0
0
139
1090
1.33
2.37
1.4
1.4
—
—
—
0
0
14
59
2.40
2.30
1.0
1.4
—
—
—
0
0
52
344
1.55
2.25
1.8
1.5
—
—
—
0
0
8
24
3.36
2.18
3.4
4.3
—
—
—
0
0
14
62
2.28
2.08
1.0
1.4
—
—
—
0
0
9
31
2.92
2.07
1.8
1.1
—
—
—
0
0
34
207
1.67
2.07
1.4
1.7
—
—
—
0
0
790
7692
1.57
2.07
43.6
17.6
39.03
39.65
%
2.51
751
7177
9
32
2.83
2.00
1.0
1.5
—
—
—
0
0
9
32
2.83
2.00
1.0
1.5
—
—
—
0
0
790
7697
1.56
2.00
42.7
17.6
258.04
256.55
e9/l
0.20
785
7474
33
203
1.65
1.95
1.1
1.1
—
—
—
0
0
5
11
4.57
1.94
1.2
1.1
—
—
—
0
0
790
7702
1.55
1.93
42.5
17.6
4.33
4.45
e12/l
9.42
784
7452
33
204
1.64
1.92
1.1
1.1
—
—
—
0
0
790
7705
1.54
1.89
43.1
17.7
129.18
133.66
g/l
15.10
790
7574
16
79
2.05
1.86
1.2
1.3
—
—
—
0
0
11
47
2.36
1.78
1.6
1.1
—
—
—
0
0
22
126
1.77
1.69
2.6
2.2
20.84
87.02
ug/min
1.15
13
67
41
593
0.68
1.68
1.5
1.8
—
—
—
0
0
14
69
2.05
1.65
1.1
1.2
—
—
—
0
0
50
354
1.44
1.62
1.5
1.4
—
—
—
0
0
5
14
3.59
1.61
1.0
1.6
—
—
—
0
0
14
71
1.99
1.54
1.1
1.2
—
—
—
0
0
164
1394
1.22
1.46
5.1
3.8
1.01
1.02
kg/l
0.77
27
213
18
103
1.76
1.41
1.2
1.3
—
—
—
0
0
23
359
0.63
1.38
1.1
1.1
—
—
—
0
0
27
175
1.56
1.36
1.1
1.2
196.09
204.11
miu/ml
0.04
11
85
11
55
2.01
1.27
1.0
1.3
—
—
—
0
0
11
55
2.01
1.27
1.0
1.3
—
—
—
0
0
11
55
2.01
1.27
1.0
1.3
—
—
—
0
0
14
77
1.83
1.26
4.6
3.9
—
—
—
0
0
16
94
1.72
1.18
1.8
1.5
—
—
—
0
0
8
41
1.96
1.09
1.3
1.2
—
—
—
0
0
8
41
1.96
1.09
1.3
1.2
—
—
—
0
0
66
526
1.28
1.07
2.1
3.6
123.19
61.16
u/ml
0.36
60
512
8
149
0.53
1.04
1.6
1.6
—
—
—
0
0
5
22
2.28
1.03
1.2
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
22
2.28
1.03
1.6
2.7
163.60
125.77
%
—
5
22
44
571
0.76
1.01
2.8
2.9
0.83
0.73
ug/l
0.30
30
371
7
36
1.95
0.97
1.6
1.4
83.43
77.92
umol/l
—
7
36
0
31
0.00
0.96
0.0
1.1
—
—
—
0
0
41
313
1.33
0.93
1.5
1.4
—
—
—
0
0
10
56
1.80
0.88
2.6
2.2
—
—
—
0
0
8
46
1.75
0.82
1.0
1.5
—
—
—
0
0
103
893
1.18
0.79
5.0
4.5
34.47
32.65
%
1.00
90
571
14
90
1.57
0.78
1.2
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
2.9
—
—
—
0
0
22
157
1.41
0.77
1.5
1.5
18.30
3.40
iu/l
—
6
47
15
100
1.51
0.73
1.1
1.1
—
13.81
—
0
9
14
94
1.50
0.67
1.0
1.0
0.54
1.44
u/ml
—
5
45
6
36
1.67
0.56
2.3
2.4
—
—
—
0
0
32
258
1.25
0.54
1.4
1.7
—
—
—
0
0
6
38
1.58
0.54
1.2
1.0
—
—
—
0
0
10
66
1.52
0.52
2.1
2.0
—
—
—
0
0
155
1429
1.10
0.50
1.5
1.4
—
—
—
0
0
18
139
1.30
0.44
1.3
1.4
—
—
—
0
0
16
122
1.32
0.42
1.8
1.7
6898.70
10597.32
e6/l
—
10
87
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
24
195
1.24
0.41
1.5
1.6
—
—
—
0
0
11
147
0.74
0.37
1.2
1.3
514.45
485.85
mg/l
0.10
11
138
10
135
0.74
0.36
1.2
1.2
3.50
3.63
mmol/l
—
10
129
14
174
0.80
0.30
1.4
1.5
389.86
311.37
mu/l
0.26
14
163
71
769
0.92
0.27
3.3
4.3
18.85
20.82
%
0.54
28
362
5
71
0.70
0.26
1.2
1.2
—
—
—
0
0
14
115
1.22
0.23
1.4
1.5
—
—
—
0
0
5
40
1.25
0.22
1.2
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
100
947
1.06
0.21
4.2
5.0
1.77
2.81
ug/l
1.42
90
839
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
10
81
1.24
0.19
1.1
1.1
—
—
—
0
0
44
476
0.92
0.18
1.8
1.9
—
—
—
0
0
5
66
0.76
0.17
2.0
1.6
—
—
—
0
0
14
162
0.86
0.16
3.9
3.6
26.75
22.59
mg/l
—
8
93
19
171
1.11
0.12
10.7
3.9
3.97
3.82
mmol/l
0.30
19
171
22
200
1.10
0.12
1.4
1.6
—
—
—
0
0
23
212
1.09
0.10
1.3
1.2
—
—
—
0
0
6
70
0.86
0.07
2.0
1.6
—
—
—
0
0
83
853
0.97
0.07
7.7
6.1
—
—
—
0
0
42
428
0.98
0.01
1.5
1.8
—
—
—
0
0
28
283
0.99
0.00
1.4
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
7
75
0.93
-0.00
4.7
2.1
13.66
13.14
%
—
7
75
0
7
0.00
-0.00
0.0
1.0
—
68.57
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.8
1.4
1.67
1.60
g/l
—
5
50
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
90
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CHIRBIL_PRIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRBIL_PRIM | 2.18 [1.95, 2.44] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.801 |
During the follow-up period (1.1.1998 — 31.12.2019), 822 out of 3020 females with CHIRBIL_PRIM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRBIL_PRIM | 2.489 [2.04, 3.04] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 293 out of 744 males with CHIRBIL_PRIM died.
Mortality risk
Mortality risk for people of age
years, who have CHIRBIL_PRIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.429% |
| 5 | 1.305% | 2.574% |
| 10 | 3.684% | 6.805% |
| 15 | 7.08% | 12.789% |
| 20 | 12.048% | 21.548% |
Relationships between endpoints
↥Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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