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Disorders of iron metabolism

DOID EFO Endpoint Browser PheWeb

E4_IRON_MET

hereditary hemochromatosis type 1: Hemochromatosis type 1 (classic) is the most common form of hereditary hemochromatosis (HH), a group of diseases characterized by excessive tissue iron deposition. Due to its incidence (1/200-1/1000), it is not considered as a rare disease, unlike the other subforms of the disease

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E83.1
  • Hospital discharge: ICD-9 — 2750
  • Cause of death: ICD-10 — E83.1
  • Cause of death: ICD-9 — 2750

2 out of 7 registries used, show all original rules.

588

4. Check minimum number of events

None

588

5. Include endpoints

None

588

6. Filter based on genotype QC (FinnGen only)

559

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E83
Name in latin
Perturbationes metabolismi ferri

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2585 1043 1510
Only index persons 2299 965 1334
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.04 0.04 0.05
Median age at first event (years)
Whole population 55.61 56.88 54.60
Only index persons 55.33 56.71 54.33

-FinnGen-

Key figures

All Female Male
Number of individuals 559 265 294
Unadjusted period prevalence (%) 0.12 0.09 0.13
Median age at first event (years) 56.08 55.31 56.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
588
Matched controls
5880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.1
ICD-10 Finland
Disorders of iron metabolism
4503599627370496.0
307.7
580
*
TPH00
NOMESCO Finland
Phlebotomy
216.2
133.8
134
8
SPAT1074
SPAT
Venesection
124.0
88.9
94
9
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
13.6
67.8
66
54
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
13.8
55.3
53
42
B99
ICPC
Blood/lymph/spleen disease other
118.7
50.7
54
5
TPH00, ,
SPAT
272.7
49.9
50
*
M14.5*E83.1
ICD-10 Finland
Arthropathy in haemochromatosis
+∞
46.5
44
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
12.8
34.4
34
28
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
32.2
99
275
K76.9
ICD-10 Finland
Liver disease, unspecified
9.0
20.8
26
30
B04
ICPC
Blood symptom/complaint
24.5
13.9
19
8
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
4.4
13.6
35
84
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
6.3
13.5
23
38
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
12.5
13.2
23
19
B28
ICPC
Limited function/disability (B)
38.4
12.3
15
*
Z31.5
ICD-10 Finland
Genetic counselling
3.3
11.9
46
147
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.0
11.0
49
171
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
10.9
138
775
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.2
10.6
22
44
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
10.6
84
392
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
10.9
10.3
19
18
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
5.1
10.1
21
42
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
10.9
9.8
18
17
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
11.6
9.6
17
15
M14.5
ICD-10 Finland
Arthropathies in other endocrine, nutritional and metabolic disorders
+∞
9.4
9
*
2750A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of iron metabolism[HAEMOCHROMATOSIS]
+∞
9.4
9
*
R53
ICD-10 Finland
Malaise and fatigue
1.9
8.7
127
743
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
8.7
157
983
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.6
8.6
51
207
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
18.6
7.6
11
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.5
244
1781
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.1
7.3
75
387
V03AC03
ATC
deferasirox; oral
+∞
7.3
7
*
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
7.3
7
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
7.0
126
785
ZXA10
NOMESCO Finland
Bilateral
1.9
6.9
94
537
C03DA01
ATC
spironolactone; oral
2.2
6.8
59
285
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
9.5
6.8
13
14
XW000
NOMESCO Finland
Bone marrow biopsy
3.0
6.7
29
100
D75.1
ICD-10 Finland
Secondary polycythaemia
10.2
6.6
12
12
127
Kela drug reimbursment
Transplant complication
6.3
6.5
16
26
A02BC02
ATC
pantoprazole; systemic
1.6
6.5
369
3035
E83.0
ICD-10 Finland
Disorders of copper metabolism
+∞
6.3
6
*
R03AC02
ATC
salbutamol; inhalant
1.5
6.2
301
2378
J45.8
ICD-10 Finland
Mixed asthma
3.7
6.2
19
52
D45
ICD-10 Finland
Polycythaemia vera
8.7
6.1
12
14

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
438
625
24.55
307.65
7.5
2.2
23.04
14.23
umol/l
53.40
423
593
429
533
27.07
307.65
7.4
2.2
45.00
24.08
%
53.53
392
460
437
573
26.80
307.65
7.3
2.1
2.15
2.38
g/l
12.44
417
537
515
1933
14.41
148.71
11.0
2.5
256.80
133.13
ug/l
8.78
497
1805
165
398
5.37
66.98
2.8
2.3
0.23
0.22
g/l
2.05
155
373
273
991
4.28
65.50
3.5
2.0
2.40
3.10
mg/l
6.36
242
868
328
1550
3.52
49.73
3.9
3.1
56.52
32.35
u/l
0.53
311
1479
349
1792
3.33
44.68
6.0
4.7
36.97
36.14
g/l
2.23
328
1681
409
2378
3.36
41.10
6.9
6.2
13.04
11.43
umol/l
1.00
398
2271
387
2187
3.25
40.66
6.9
6.4
—
—
—
0
0
70
137
5.66
34.88
1.3
1.2
80.00
87.69
titre
—
7
13
394
2371
3.01
34.73
6.1
6.0
1.97
1.97
e9/l
0.02
365
2156
385
2302
2.95
34.08
6.1
6.0
0.56
0.57
e9/l
0.61
349
2034
385
2311
2.93
33.67
6.1
6.0
0.04
0.04
e9/l
0.11
349
2042
391
2377
2.92
33.18
6.2
6.3
0.19
0.19
e9/l
0.03
363
2139
507
3591
3.99
32.58
10.0
7.2
78.76
76.86
u/l
0.42
491
3374
355
2075
2.79
32.09
6.3
6.1
0.74
0.69
%
1.29
337
1944
341
1976
2.73
30.97
12.8
11.3
1.14
1.23
inr
1.54
120
614
370
2236
2.77
30.85
6.4
6.1
30.99
28.40
%
5.37
353
2109
366
2206
2.75
30.58
6.0
5.9
54.26
56.61
%
3.84
350
2080
361
2161
2.74
30.57
6.3
6.1
3.10
2.93
%
0.69
344
2029
362
2177
2.72
30.26
6.6
6.4
8.83
8.60
%
0.84
344
2048
227
1092
2.76
29.59
5.2
3.5
89.70
92.38
%
0.80
219
1069
114
386
3.42
27.51
2.0
2.1
351.04
355.07
nmol/l
0.09
107
365
155
637
2.95
26.87
1.4
1.3
661.71
430.41
titre
0.63
35
146
108
388
3.18
23.45
2.1
2.7
11.13
10.32
g/l
1.31
95
362
457
3308
2.71
22.89
4.9
3.0
58.53
47.20
u/l
1.82
442
3126
395
2675
2.45
22.80
8.0
9.3
3.60
4.00
e9/l
3.57
363
2371
92
316
3.27
21.44
1.4
1.7
0.98
1.36
g/l
2.12
80
291
324
2056
2.28
21.13
13.1
8.6
0.00
0.00
e9/l
0.57
276
1713
46
101
4.86
19.96
1.5
1.3
—
—
—
0
0
107
448
2.70
17.31
3.3
2.8
2.06
1.73
%
1.52
96
414
87
329
2.93
17.03
3.6
3.0
84.31
71.11
e9/l
1.40
63
266
453
3463
2.34
16.87
4.4
3.9
9.32
10.96
mm/h
1.89
429
3208
87
336
2.87
16.37
3.4
4.9
0.06
0.14
%
0.47
18
98
90
355
2.81
16.28
3.4
4.9
0.00
0.15
%
3.06
22
115
308
2061
2.04
15.88
9.6
6.3
1.22
1.21
mmol/l
1.10
253
1762
286
1868
2.03
15.73
7.9
5.7
1.22
1.21
mmol/l
0.60
259
1709
93
382
2.70
15.54
3.3
4.7
0.25
1.03
%
4.36
24
140
95
401
2.63
15.02
3.0
3.2
—
—
—
0
0
193
1109
2.10
14.89
2.4
2.8
622.53
850.58
ng/l
0.77
151
934
270
1762
1.98
14.55
2.7
2.1
72.53
77.08
nmol/l
1.96
244
1584
202
1194
2.05
14.35
2.8
2.4
4535.23
6372.82
umol/l
0.24
183
1052
166
912
2.14
14.33
1.5
1.4
2.61
2.51
g/l
0.26
127
588
111
530
2.35
13.39
1.8
1.6
—
—
—
0
0
82
341
2.63
13.30
3.3
4.6
1.90
0.50
%
0.38
21
115
443
3498
2.08
13.08
4.5
3.6
14.72
14.69
pmol/l
0.10
405
3198
135
712
2.16
12.78
2.0
1.6
1222.17
1226.97
nmol/l
0.02
110
558
255
1686
1.90
12.75
2.1
1.8
95.06
96.94
pmol/l
0.25
133
890
121
616
2.21
12.48
4.2
3.6
0.81
0.83
mmol/l
1.03
113
589
195
1206
1.92
11.74
5.8
3.6
7.41
7.40
ph
0.83
44
238
48
166
3.06
10.93
1.6
2.4
1.21
1.48
g/l
1.10
38
144
203
1297
1.86
10.91
3.7
3.0
—
—
—
0
0
103
521
2.18
10.70
4.8
2.6
7.49
7.99
umol/l
0.12
98
458
96
473
2.23
10.63
9.7
5.4
1.05
1.02
mmol/l
0.60
90
445
158
949
1.91
10.18
1.7
1.5
20.98
20.33
nmol/l
0.15
126
815
501
4283
2.15
9.99
5.5
4.2
1.95
1.88
mu/l
0.48
462
3929
162
994
1.87
9.72
1.4
1.2
1.39
1.71
u/ml
0.16
46
281
121
681
1.98
9.37
1.8
1.6
—
—
—
0
0
18
21
8.80
8.85
3.0
2.7
34122.22
42090.48
ug/l
1.23
18
21
139
844
1.85
8.49
2.8
2.4
549.13
571.04
mosm/kgh2o
0.48
126
723
394
3200
1.70
8.21
4.3
3.8
—
—
—
0
0
136
833
1.82
8.04
1.8
1.6
417.88
44039687.13
pmol/l
1.07
110
713
536
4808
2.30
7.85
16.8
12.0
17.92
23.88
mg/l
4.56
440
3728
85
462
1.98
7.19
2.6
2.2
14.45
13.85
nmol/l
0.30
72
431
203
1435
1.63
7.01
3.3
3.3
2.35
2.35
mmol/l
0.00
183
1270
16
24
6.82
6.85
1.0
1.0
—
—
—
0
0
18
32
5.77
6.80
1.2
1.0
—
—
—
0
0
501
4457
1.84
6.44
6.5
4.9
37.49
38.97
mmol/mol
3.45
476
4160
20
56
3.66
6.36
2.1
2.5
34.50
33.11
pg
0.74
20
56
16
27
6.06
6.34
1.0
1.0
—
—
—
0
0
227
1680
1.57
6.33
3.9
2.9
26.83
59.67
ng/l
0.75
152
1087
178
1247
1.61
6.25
3.8
3.3
0.00
0.00
estimate
0.80
91
424
199
1433
1.59
6.22
3.1
2.3
61.10
61.38
u/l
0.02
187
1333
325
2619
1.54
6.10
6.5
4.3
6.58
6.57
mmol/l
0.05
304
2441
28
100
2.89
6.08
1.5
1.5
—
—
—
0
0
182
1297
1.58
5.90
3.2
2.6
—
—
—
0
0
52
255
2.14
5.80
5.3
3.7
90.93
83.62
ng/l
0.22
44
228
136
906
1.65
5.79
2.5
2.3
3.84
5.55
e6/l
0.84
125
822
64
341
1.98
5.72
3.8
3.2
1.23
1.23
mmol/l
0.08
51
299
25
89
2.89
5.47
2.8
3.4
4.09
4.24
e9/l
0.11
25
89
16
33
4.95
5.46
1.4
1.2
—
—
—
0
0
19
58
3.35
5.35
2.2
2.3
—
—
—
0
0
72
410
1.86
5.29
3.2
3.8
—
—
—
0
0
99
621
1.71
5.26
1.2
1.2
—
—
—
0
0
25
92
2.79
5.17
2.9
3.7
56.84
56.60
%
0.03
25
92
48
239
2.10
5.16
3.1
2.9
4.59
4.47
pmol/l
0.48
40
212
40
185
2.25
5.16
1.5
1.4
—
14.58
—
0
6
473
4219
1.62
5.07
25.4
14.1
14.81
14.92
%
0.14
467
4152
25
93
2.76
5.07
4.8
2.9
47.50
35.05
umol/l
1.24
25
85
25
93
2.76
5.07
1.6
1.5
128.38
110.41
u/ml
—
8
17
175
1295
1.50
4.61
3.8
3.5
8.25
6.17
mg/mmol
0.38
104
804
61
345
1.86
4.59
1.4
1.5
—
—
—
0
0
21
77
2.79
4.39
1.4
1.9
0.58
0.72
g/l
0.26
16
55
168
1250
1.48
4.26
2.1
2.0
128.47
254.88
u/l
1.36
158
1181
512
4712
1.67
4.23
5.4
4.1
5.87
5.88
mmol/l
0.05
479
4326
26
109
2.45
4.20
1.3
1.3
—
—
—
0
0
39
196
2.06
4.13
1.2
1.3
—
—
—
0
0
277
2279
1.41
4.03
3.5
3.1
0.00
0.00
estimate
-0.00
93
460
118
826
1.54
3.98
1.3
1.3
24.86
38.59
iu/ml
0.76
21
262
163
1220
1.46
3.98
3.2
3.1
953.33
354.43
mg/l
0.44
102
784
173
1318
1.44
3.83
3.3
2.8
22.98
107.44
e6/l
1.04
141
1033
111
773
1.54
3.83
2.2
2.9
2.42
2.44
mmol/l
0.67
96
679
114
802
1.52
3.75
1.3
1.3
9.86
13.11
u/ml
0.24
46
341
174
1334
1.43
3.71
3.4
2.9
8.38
8.31
mmol/l
0.06
142
1128
26
116
2.30
3.69
1.2
1.4
323.00
277.25
ug/g
0.50
14
69
160
1209
1.44
3.68
3.2
2.7
0.23
0.46
e6/l
1.49
128
926
20
79
2.59
3.67
1.1
1.1
—
—
—
0
0
273
2269
1.38
3.61
4.6
4.1
0.00
0.00
estimate
0.50
92
434
152
1142
1.45
3.60
2.8
2.6
—
—
—
0
0
531
4973
1.70
3.60
19.6
13.1
139.72
139.78
mmol/l
0.22
523
4844
20
80
2.55
3.58
4.5
3.0
—
—
—
0
0
553
5243
1.92
3.54
14.9
9.4
32.39
27.79
u/l
5.77
544
5066
46
259
1.84
3.54
3.7
3.5
7.41
7.41
ph
—
10
35
134
987
1.46
3.51
1.7
1.7
1.18
1.03
mg/l
0.25
103
759
8
13
6.22
3.51
1.3
1.6
—
—
—
0
0
6
6
10.09
3.50
1.0
1.0
—
—
—
0
0
19
75
2.58
3.49
1.1
1.1
—
—
—
0
0
382
3363
1.39
3.49
4.3
3.4
—
—
—
0
0
116
832
1.49
3.47
2.0
1.8
—
—
—
0
0
36
188
1.97
3.46
1.2
1.2
—
2.37
—
0
12
532
4995
1.68
3.44
19.9
13.1
3.95
3.97
mmol/l
0.96
523
4857
155
1182
1.42
3.36
3.1
2.7
—
—
—
0
0
273
2295
1.35
3.25
3.6
3.1
0.00
0.01
estimate
0.50
88
420
68
445
1.60
3.08
10.9
8.9
1.12
1.11
mmol/l
0.01
59
355
32
169
1.94
3.01
1.3
1.2
—
—
—
0
0
191
1534
1.36
3.01
3.9
3.2
69.95
100.90
e6/l
0.37
148
1111
17
69
2.51
2.98
3.5
2.5
—
—
—
0
0
35
195
1.85
2.82
2.0
1.8
34.86
39.12
nmol/l
0.84
35
189
14
53
2.68
2.81
2.9
2.5
—
—
—
0
0
21
97
2.21
2.80
3.6
4.1
8.17
8.25
kpa
0.07
21
97
17
73
2.37
2.67
3.8
2.0
—
—
—
0
0
17
73
2.37
2.67
3.1
2.5
—
—
—
0
0
26
134
1.98
2.64
1.8
1.3
3.53
7.13
u/l
3.61
20
111
25
127
2.01
2.64
2.4
2.7
—
—
—
0
0
50
316
1.64
2.62
13.2
8.5
—
—
—
0
0
516
4868
1.49
2.59
4.6
4.1
4.55
4.74
mmol/l
4.55
489
4550
45
278
1.67
2.58
1.4
2.4
—
—
—
0
0
6
11
5.50
2.55
1.0
2.2
—
—
—
0
0
14
56
2.54
2.54
1.3
1.4
—
—
—
0
0
537
5115
1.57
2.50
21.0
11.2
—
—
—
0
0
47
297
1.63
2.48
1.2
1.2
279.97
131.11
iu/ml
0.77
18
129
332
2943
1.29
2.46
4.2
3.9
231.17
199.53
e6/l
—
6
40
13
51
2.58
2.46
1.5
1.3
—
—
—
0
0
34
197
1.77
2.45
15.8
13.2
—
—
—
0
0
11
38
2.93
2.42
1.0
1.4
—
—
—
0
0
47
299
1.62
2.42
3.2
2.9
179.74
157.47
ng/l
0.23
39
269
6
12
5.04
2.40
3.7
5.6
46.08
46.67
%
—
6
12
497
4671
1.41
2.40
4.2
3.7
1.35
1.30
mmol/l
0.94
464
4322
25
132
1.93
2.39
1.2
1.2
—
2.45
—
0
14
57
381
1.55
2.39
1.3
1.4
—
—
—
0
0
142
1125
1.35
2.38
5.4
4.2
—
—
—
0
0
12
46
2.64
2.37
1.3
1.3
—
—
—
0
0
7
17
4.15
2.36
1.0
1.0
—
—
—
0
0
21
105
2.04
2.33
1.3
1.2
270.25
279.54
u/ml
—
8
66
521
4948
1.46
2.28
5.1
4.4
2.70
2.85
mmol/l
3.42
488
4596
6
13
4.65
2.27
1.0
1.2
—
—
—
0
0
512
4850
1.43
2.24
4.6
4.0
1.37
1.45
mmol/l
4.50
481
4505
140
1118
1.33
2.22
7.4
6.6
—
—
—
0
0
90
670
1.41
2.21
2.8
2.7
3.65
1.79
e6/l
0.73
46
372
49
325
1.55
2.14
3.1
2.6
3.32
5.40
e9/l
1.76
36
276
17
82
2.11
2.08
1.2
1.2
—
—
—
0
0
10
37
2.73
2.08
2.2
2.7
0.66
0.79
g/24h
—
5
17
154
1261
1.30
2.03
1.6
1.6
1.47
1.37
mmol/l
0.66
117
1064
73
532
1.42
2.03
1.8
1.5
—
—
—
0
0
32
194
1.69
2.01
3.4
3.9
—
—
—
0
0
76
560
1.41
1.99
2.3
2.3
59.15
115.97
ug/g
4.26
54
454
7
21
3.36
1.97
1.0
1.0
—
—
—
0
0
225
1949
1.25
1.86
2.9
2.5
—
—
—
0
0
40
263
1.56
1.84
5.0
6.8
—
—
—
0
0
215
1855
1.25
1.83
2.0
2.0
—
—
—
0
0
28
169
1.69
1.80
1.8
2.8
—
—
—
0
0
13
60
2.19
1.79
1.2
1.2
—
—
—
0
0
23
132
1.77
1.76
2.7
2.2
185.39
2810.35
u/l
—
10
51
6
18
3.36
1.75
1.0
1.0
—
—
—
0
0
6
18
3.36
1.75
1.2
1.1
—
—
—
0
0
12
55
2.21
1.68
1.3
1.3
—
—
—
0
0
36
237
1.55
1.67
1.0
1.1
—
—
—
0
0
5
14
3.59
1.62
1.2
1.1
—
—
—
0
0
243
2149
1.22
1.60
3.4
2.5
—
—
—
0
0
48
340
1.45
1.59
7.5
3.2
2.10
2.19
mmol/l
0.04
41
280
17
92
1.87
1.57
1.4
1.7
6.57
5.97
iu/l
—
5
25
10
45
2.24
1.47
2.6
2.5
1.33
1.09
e9/l
—
10
38
165
1414
1.23
1.46
3.2
2.2
—
—
—
0
0
6
22
2.74
1.43
2.2
1.5
10.43
12.19
%
—
6
22
6
22
2.74
1.43
1.2
1.0
—
—
—
0
0
15
81
1.87
1.41
1.6
1.6
—
—
—
0
0
207
1821
1.21
1.41
3.0
2.9
5.83
5.83
ph
0.00
15
165
23
142
1.64
1.40
1.0
1.4
174.04
217.39
miu/ml
—
5
71
9
41
2.21
1.37
1.1
1.2
—
—
—
0
0
5
17
2.96
1.36
1.0
1.1
—
—
—
0
0
11
54
2.06
1.33
1.4
1.5
—
—
—
0
0
9
43
2.11
1.30
1.1
1.0
—
—
—
0
0
8
34
2.37
1.29
2.3
2.1
2.51
3.57
ug/l
—
8
29
5
18
2.79
1.28
6.8
6.0
—
—
—
0
0
75
594
1.30
1.28
1.7
1.5
—
—
—
0
0
10
48
2.10
1.28
3.5
4.1
—
—
—
0
0
6
25
2.41
1.24
1.0
1.2
171.37
139.97
iu/ml
—
6
25
8
36
2.24
1.24
1.4
1.1
—
—
—
0
0
10
49
2.06
1.22
1.5
1.5
—
—
—
0
0
47
350
1.37
1.22
1.2
1.2
—
—
—
0
0
6
26
2.32
1.19
1.3
3.3
60.50
66.88
nmol/l
—
6
26
11
57
1.95
1.17
1.1
1.0
2.36
3.03
u/ml
—
6
24
15
87
1.74
1.16
4.0
2.1
139.60
131.53
g/l
—
10
66
14
80
1.77
1.13
1.3
2.0
—
—
—
0
0
26
176
1.50
1.12
2.3
2.0
2.12
3.07
ug/l
0.20
26
157
7
33
2.13
1.06
2.6
2.4
32.41
36.21
%
—
7
33
8
150
0.53
1.04
7.4
10.0
—
—
—
0
0
16
98
1.65
1.04
2.5
3.1
—
—
—
0
0
92
769
1.23
1.04
3.7
3.3
1226.24
552.79
ng/l
0.35
63
564
5
22
2.28
1.03
2.0
1.2
0.20
1.06
u/field
—
5
17
5
22
2.28
1.03
1.2
1.1
1586.20
1598.18
miu/ml
—
5
22
9
48
1.89
1.01
1.3
1.3
92.10
90.07
%
—
9
48
11
61
1.82
0.99
1.4
1.4
40.26
27.16
u/l
0.43
11
53
9
49
1.85
0.99
1.2
1.6
269.38
182.53
pmol/l
—
9
49
14
84
1.68
0.98
1.7
1.3
—
—
—
0
0
559
5482
1.40
0.98
32.4
17.6
41.64
40.92
%
2.04
537
5150
7
37
1.90
0.94
3.1
2.7
0.23
0.22
e9/l
—
7
31
6
27
2.23
0.93
1.2
2.4
724.17
1548.81
u/ml
—
6
27
559
5486
1.38
0.93
32.1
17.6
233.13
248.22
e9/l
6.89
548
5359
54
430
1.28
0.93
2.5
4.7
3.02
33.77
ug/l
0.98
42
350
13
78
1.68
0.92
1.4
1.2
6.67
4.29
u/ml
—
6
34
559
5488
1.38
0.91
32.2
17.6
6.36
6.58
e9/l
1.93
545
5344
559
5488
1.38
0.91
31.9
17.4
31.59
30.36
pg
38.63
553
5410
559
5488
1.38
0.91
31.9
17.5
93.44
90.89
fl
27.53
553
5410
73
605
1.24
0.90
1.3
1.2
—
—
—
0
0
559
5489
1.37
0.89
32.1
17.5
4.53
4.58
e12/l
1.18
544
5348
13
79
1.66
0.88
4.0
2.3
15.76
16.63
%
—
8
42
67
552
1.24
0.88
1.3
1.3
—
—
—
0
0
66
544
1.24
0.86
1.7
1.6
—
—
—
0
0
559
5492
1.36
0.86
32.2
17.6
141.99
138.23
g/l
6.22
553
5412
8
46
1.75
0.82
2.0
3.1
1.79
3.00
nmol/l
—
8
46
33
250
1.34
0.82
1.7
1.7
—
—
—
0
0
16
106
1.52
0.79
5.0
3.4
7.41
7.42
ph
0.41
16
90
6
33
1.83
0.79
2.3
1.4
0.79
1.04
g/l
—
6
33
79
671
1.20
0.79
1.9
2.0
—
—
—
0
0
14
90
1.57
0.78
1.6
1.6
—
—
—
0
0
5
98
0.51
0.78
1.0
1.1
—
—
—
0
0
5
98
0.51
0.78
1.0
1.1
—
—
—
0
0
50
405
1.26
0.77
5.8
2.4
31.95
147.87
u/l
0.50
38
353
11
67
1.65
0.75
1.3
1.1
—
—
—
0
0
37
290
1.29
0.74
1.3
1.2
—
—
—
0
0
5
25
2.01
0.73
1.0
1.1
—
9.13
—
0
6
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
7
39
1.80
0.72
3.1
2.5
462.00
451.71
e6/l
—
7
31
7
41
1.72
0.70
2.1
1.3
85.43
78.63
umol/l
—
7
41
11
69
1.61
0.68
3.0
2.6
—
—
—
0
0
21
153
1.39
0.68
1.5
2.1
23.20
21.30
s
1.01
15
135
5
29
1.73
0.64
1.6
1.5
—
—
—
0
0
5
29
1.73
0.64
3.6
1.8
—
—
—
0
0
59
500
1.20
0.63
8.9
6.7
103.46
104.41
mmol/l
0.65
59
500
121
1089
1.14
0.61
3.0
2.1
—
—
—
0
0
31
246
1.27
0.59
1.3
1.2
—
—
—
0
0
14
97
1.45
0.59
1.1
1.3
2.50
7.95
e6/l
—
6
78
14
97
1.45
0.59
1.1
1.3
82.63
1254.59
e6/l
—
8
80
27
212
1.29
0.56
2.7
2.2
—
—
—
0
0
23
177
1.31
0.55
1.3
1.4
—
—
—
0
0
23
177
1.31
0.55
1.3
1.4
—
—
—
0
0
23
177
1.31
0.55
1.3
1.4
—
—
—
0
0
25
196
1.29
0.53
3.0
2.0
1.26
1.35
%
0.15
25
196
20
152
1.33
0.52
1.6
3.7
0.13
0.20
g/l
—
6
64
9
63
1.44
0.52
4.1
2.2
—
—
—
0
0
19
144
1.33
0.51
1.7
1.7
—
—
—
0
0
7
46
1.53
0.48
1.0
1.3
—
—
—
0
0
7
48
1.46
0.47
1.7
2.1
—
—
—
0
0
22
174
1.27
0.45
1.3
1.4
—
—
—
0
0
22
174
1.27
0.45
3.8
3.9
24.30
24.70
mmol/l
0.61
22
168
201
1896
1.09
0.44
4.0
4.5
1.98
2.33
ug/l
0.51
174
1719
6
94
0.63
0.42
1.8
1.5
—
—
—
0
0
11
79
1.40
0.41
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
27
225
1.21
0.37
2.9
2.4
1.02
0.17
e6/l
0.46
27
217
9
71
1.27
0.36
3.0
2.0
12.78
13.12
%
—
9
71
5
78
0.64
0.36
2.2
1.5
—
—
—
0
0
6
42
1.43
0.35
1.5
1.2
—
—
—
0
0
6
42
1.43
0.35
2.5
2.6
—
—
—
0
0
17
135
1.27
0.35
1.1
1.1
—
—
—
0
0
12
91
1.33
0.34
1.2
1.3
—
—
—
0
0
6
90
0.66
0.33
1.7
1.4
—
—
—
0
0
6
90
0.66
0.33
1.7
1.4
—
—
—
0
0
18
146
1.24
0.32
1.4
1.6
—
—
—
0
0
44
494
0.88
0.31
1.2
1.4
—
—
—
0
0
23
193
1.20
0.31
2.9
2.0
0.59
0.64
%
0.52
23
193
7
56
1.25
0.29
1.1
1.1
—
—
—
0
0
24
205
1.18
0.28
3.1
2.6
—
—
—
0
0
19
159
1.20
0.27
1.3
1.4
—
—
—
0
0
12
95
1.27
0.26
1.7
4.4
—
—
—
0
0
54
492
1.11
0.26
1.7
1.4
—
—
—
0
0
16
133
1.21
0.24
1.4
1.4
—
—
—
0
0
15
180
0.83
0.24
2.9
4.6
—
—
—
0
0
33
370
0.89
0.24
3.7
3.0
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
5
42
1.19
0.21
1.8
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
16.15
—
0
10
0
10
0.00
0.21
0.0
5.8
—
—
—
0
0
0
10
0.00
0.21
0.0
5.5
—
612.50
—
0
10
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
5
43
1.16
0.21
1.8
2.0
105.80
105.67
mmol/l
—
5
43
5
43
1.16
0.21
1.8
2.0
4.24
3.99
mmol/l
—
5
43
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
9
114
0.79
0.20
3.1
2.2
—
—
—
0
0
53
571
0.92
0.20
1.2
1.4
—
—
—
0
0
12
99
1.22
0.19
1.2
1.7
—
—
—
0
0
17
196
0.86
0.19
1.2
1.1
—
—
—
0
0
97
1018
0.94
0.18
3.6
3.3
1.01
1.02
kg/l
0.51
12
135
118
1131
1.05
0.18
2.7
2.9
0.67
0.71
ug/l
0.17
73
722
23
205
1.13
0.17
2.3
1.6
—
—
—
0
0
19
167
1.14
0.17
1.1
1.1
—
—
—
0
0
140
1351
1.05
0.16
1.6
1.4
—
—
—
0
0
39
363
1.08
0.14
1.3
1.4
—
—
—
0
0
36
336
1.08
0.12
1.3
1.4
—
—
—
0
0
10
116
0.86
0.12
1.7
1.2
—
—
—
0
0
15
134
1.12
0.11
1.2
1.1
—
—
—
0
0
14
125
1.12
0.10
1.0
1.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.3
—
—
—
0
0
6
54
1.11
0.09
1.3
1.4
—
—
—
0
0
7
64
1.09
0.08
1.4
1.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.4
—
—
—
0
0
28
296
0.94
0.07
2.9
2.4
—
—
—
0
0
99
1005
0.98
0.04
3.5
3.2
—
—
—
0
0
12
112
1.07
0.03
22.8
1.6
—
—
—
0
0
41
413
0.99
0.00
1.9
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
9
99
0.91
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
16.12
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
0.33
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
2.01
—
0
7
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
5.70
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_IRON_MET and mortality.

Females

Parameter HR [95% CI] p-value
E4_IRON_MET 1.819 [1.37, 2.42] < 0.001
Birth year 0.997 [0.99, 1.01] 0.43

During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 700 females with E4_IRON_MET died.

Males

Parameter HR [95% CI] p-value
E4_IRON_MET 2.068 [1.7, 2.51] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 1047 males with E4_IRON_MET died.

Mortality risk

Mortality risk for people of age

years, who have E4_IRON_MET.

N-year risk Females Males
1 0.185% 0.41%
5 1.129% 2.443%
10 2.835% 6.134%
15 5.252% 11.96%
20 8.954% 19.321%

Relationships between endpoints

↥

Index endpoint: E4_IRON_MET – Disorders of iron metabolism

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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