hereditary hemochromatosis type 1: Hemochromatosis type 1 (classic) is the most common form of hereditary hemochromatosis (HH), a group of diseases characterized by excessive tissue iron deposition. Due to its incidence (1/200-1/1000), it is not considered as a rare disease, unlike the other subforms of the disease
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
504 |
4. Check minimum number of eventsNone |
504 |
5. Include endpointsNone |
504 |
6. Filter based on genotype QC (FinnGen only) |
504 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E83
- Name in latin
- Perturbationes metabolismi ferri
Similar endpoints
↥List of similar endpoints to
Disorders of iron metabolism
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2585 | 1043 | 1510 |
| Only index persons | 2299 | 965 | 1334 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 55.61 | 56.88 | 54.60 |
| Only index persons | 55.33 | 56.71 | 54.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 504 | 224 | 280 |
| Unadjusted period prevalence (%) | 0.10 | 0.08 | 0.12 |
| Median age at first event (years) | 56.48 | 56.31 | 56.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 451
- Matched controls
- 4511
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.1
ICD-10 Finland
Disorders of iron metabolism
4503599627370496.0
323.0
443
*
TPH00
NOMESCO Finland
Phlebotomy
185.1
99.8
101
7
SPAT1074
SPAT
Venesection
132.2
73.5
77
7
M14.5*E83.1
ICD-10 Finland
Arthropathy in haemochromatosis
+∞
35.9
34
*
B99
ICPC
Blood/lymph/spleen disease other
73.2
30.3
34
5
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
15.7
29.1
48
34
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
14.0
27.3
47
37
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.6
20.8
77
193
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
23.2
14.3
20
9
K76.9
ICD-10 Finland
Liver disease, unspecified
12.1
12.4
22
19
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
10.9
11.9
22
21
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
6.4
11.2
29
48
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
10.7
99
469
TPH00
SPAT
NA
+∞
10.5
10
*
B04
ICPC
Blood symptom/complaint
18.0
9.5
14
8
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
8.3
9.4
20
25
2750A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of iron metabolism[HAEMOCHROMATOSIS]
+∞
9.4
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
9.2
183
1190
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
24.6
8.9
12
5
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
14.4
8.7
14
10
M14.5
ICD-10 Finland
Arthropathies in other endocrine, nutritional and metabolic disorders
91.7
8.4
9
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.6
7.6
55
227
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
7.6
61
268
B28
ICPC
Limited function/disability (B)
81.3
7.4
8
*
G47.3
ICD-10 Finland
Sleep apnoea
2.0
7.3
104
589
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
7.2
121
728
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
30.5
7.2
9
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.0
6.9
39
139
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.7
89
491
D75.1
ICD-10 Finland
Secondary polycythaemia
22.9
6.7
9
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
22.9
6.7
9
*
R53
ICD-10 Finland
Malaise and fatigue
2.1
6.7
83
445
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
12.5
6.6
11
9
XX1XT
NOMESCO Finland
Other puncture with other radiological guidance
70.8
6.4
7
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
14.6
6.4
10
7
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
6.3
6
*
V03AC03
ATC
deferasirox; oral
+∞
6.3
6
*
E83.0
ICD-10 Finland
Disorders of copper metabolism
+∞
6.3
6
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
27.1
6.2
8
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
5.3
6.1
17
33
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
374
475
27.65
322.53
8.1
2.1
42.9
23.7
%
44.51
343
418
381
510
27.51
316.85
8.0
2.0
2.2
2.4
g/l
8.57
364
481
382
560
25.05
295.80
8.3
2.0
22.3
14.1
umol/l
43.53
368
528
444
1658
15.09
129.76
12.1
2.5
238.7
146.4
ug/l
4.93
430
1545
247
866
4.63
63.70
3.6
2.0
2.5
3.2
mg/l
5.99
221
766
151
357
5.61
63.29
2.9
2.3
0.2
0.2
g/l
1.91
141
333
292
1342
3.80
47.86
4.1
3.1
59.7
32.7
u/l
0.53
277
1287
317
1601
3.64
43.56
6.0
4.5
36.9
36.0
g/l
2.19
296
1499
360
2084
3.55
37.47
7.0
6.4
13.2
11.3
umol/l
1.13
350
1994
447
3130
4.79
31.65
10.3
7.4
78.3
76.9
u/l
0.26
435
2926
106
340
3.68
28.18
2.1
2.1
353.5
362.4
nmol/l
0.20
99
319
352
2301
2.76
24.23
8.3
9.7
3.6
4.0
e9/l
2.72
325
2040
394
2837
2.78
20.48
5.2
3.0
60.2
47.4
u/l
1.92
382
2681
281
1821
2.23
17.13
9.9
6.2
1.2
1.2
mmol/l
1.28
226
1554
261
1653
2.20
16.72
8.2
5.6
1.2
1.2
mmol/l
0.67
234
1511
397
2989
2.55
16.71
4.5
3.9
9.6
11.2
mm/h
1.47
376
2764
179
1008
2.20
15.05
2.5
3.0
631.9
892.0
ng/l
0.86
143
863
240
1536
2.07
14.26
2.8
2.1
73.2
77.5
nmol/l
1.59
215
1390
25
46
5.67
13.19
1.3
1.2
—
—
—
0
0
180
1061
2.08
13.11
2.9
2.5
5103.2
6773.3
umol/l
0.19
161
921
112
554
2.31
12.61
4.1
3.7
0.8
0.8
mmol/l
1.00
104
527
125
648
2.24
12.58
2.0
1.6
1211.7
1236.4
nmol/l
0.11
102
514
381
2995
2.12
11.73
4.7
3.6
14.8
14.7
pmol/l
0.29
347
2732
90
422
2.38
11.38
9.9
5.0
1.1
1.0
mmol/l
0.65
84
396
228
1530
1.90
10.96
2.1
1.8
94.7
97.0
pmol/l
0.30
120
801
14
18
7.97
10.19
1.0
1.1
—
—
—
0
0
127
724
2.01
9.72
1.9
1.7
418.4
18578775.4
pmol/l
0.50
102
619
144
860
1.94
9.63
1.4
1.2
1.5
1.4
u/ml
0.06
41
251
43
151
3.02
9.59
1.6
2.4
1.2
1.5
g/l
0.89
35
131
89
456
2.16
9.01
5.2
2.7
7.8
8.0
umol/l
0.04
84
405
104
572
2.03
8.71
2.0
2.0
1.7
1.5
%
1.55
92
501
428
3663
2.12
8.45
5.9
4.2
2.0
1.9
mu/l
0.39
394
3359
24
63
3.95
8.34
1.0
1.0
—
—
—
0
0
140
874
1.83
7.97
1.7
1.5
20.9
20.5
nmol/l
0.09
111
748
18
39
4.75
7.93
1.2
1.2
76.3
55.2
u/l
—
8
25
185
1261
1.74
7.78
3.6
3.4
2.4
2.4
mmol/l
0.02
162
1108
52
225
2.46
7.78
5.3
3.2
90.9
82.8
ng/l
0.24
44
199
292
2296
1.65
6.85
6.8
4.5
6.6
6.6
mmol/l
0.07
274
2140
46
201
2.42
6.74
3.2
3.0
4.6
4.5
pmol/l
0.53
38
182
460
4132
2.30
6.72
17.8
12.3
18.1
24.2
mg/l
3.98
390
3207
60
297
2.16
6.58
3.9
3.2
1.2
1.2
mmol/l
0.07
50
264
19
52
3.76
6.25
2.2
2.4
34.4
33.0
pg
0.68
19
52
23
72
3.30
6.22
2.9
3.4
4.1
4.3
e9/l
0.18
23
72
177
1253
1.64
6.16
3.1
2.3
58.0
57.3
u/l
0.06
167
1170
24
79
3.14
6.00
1.6
1.5
128.4
109.6
u/ml
—
8
14
23
75
3.17
5.84
3.0
3.9
57.1
56.9
%
0.03
23
75
201
1484
1.59
5.81
4.1
3.1
28.1
64.1
ng/l
0.74
140
983
19
56
3.49
5.64
1.4
1.3
—
—
—
0
0
72
405
1.91
5.56
2.7
2.1
15.0
14.2
nmol/l
0.37
60
373
434
3885
1.84
5.38
6.9
5.1
37.7
39.3
mmol/mol
3.38
412
3630
156
1125
1.56
4.82
2.2
2.0
127.4
269.4
u/l
1.39
147
1063
151
1081
1.57
4.82
4.1
3.4
0.0
0.0
estimate
0.50
76
369
12
29
4.21
4.65
1.4
1.6
17.6
4.6
u/l
—
5
14
106
721
1.60
4.15
1.3
1.3
27.2
34.1
iu/ml
0.29
18
220
156
1168
1.49
3.93
4.2
3.7
7.5
5.7
mg/mmol
0.32
96
730
63
380
1.75
3.89
3.9
2.9
—
—
—
0
0
240
1964
1.42
3.73
3.8
3.1
0.0
0.0
estimate
0.00
77
373
146
1089
1.48
3.72
3.3
2.7
0.2
0.5
e6/l
1.36
116
832
101
700
1.55
3.63
1.3
1.3
11.4
12.5
u/ml
0.06
39
288
101
700
1.55
3.63
2.4
3.1
2.4
2.4
mmol/l
0.59
86
619
462
4316
1.85
3.62
20.9
13.6
139.7
139.8
mmol/l
0.29
456
4208
41
221
1.93
3.62
2.8
2.8
2.1
1.8
mmol/l
0.21
26
173
30
144
2.15
3.61
2.1
2.3
—
—
—
0
0
435
4005
1.63
3.51
16.7
11.2
81.3
83.2
ml/min/173m2
1.10
381
3344
463
4337
1.83
3.47
21.1
13.6
4.0
4.0
mmol/l
0.67
456
4226
196
1563
1.42
3.45
3.8
3.2
—
—
—
0
0
118
855
1.50
3.44
1.8
1.7
1.3
1.1
mg/l
0.17
90
659
70
450
1.65
3.43
22.2
18.9
1.0
1.3
inr
—
9
66
23
102
2.31
3.34
1.3
1.4
315.6
282.3
ug/g
0.31
13
61
237
1963
1.39
3.31
4.9
4.2
0.0
0.0
estimate
0.00
77
377
63
399
1.66
3.28
11.3
9.3
1.1
1.1
mmol/l
0.03
55
312
28
137
2.11
3.23
6.8
3.7
24.1
24.4
mmol/l
0.11
28
125
238
1982
1.38
3.17
3.9
3.1
0.0
0.0
estimate
0.50
74
364
17
67
2.59
3.16
2.6
3.2
—
817.1
—
0
8
179
1423
1.40
3.15
3.5
2.9
—
—
—
0
0
21
92
2.34
3.14
1.2
1.1
—
—
—
0
0
21
93
2.31
3.07
1.3
1.2
—
12.5
—
0
8
153
1192
1.41
3.01
3.6
2.9
8.6
8.2
mmol/l
0.31
121
1006
24
115
2.14
2.93
1.3
1.3
—
—
—
0
0
24
116
2.12
2.87
1.3
1.3
—
2.5
—
0
15
24
116
2.12
2.87
1.7
1.2
3.5
7.3
u/l
3.42
18
96
384
3492
1.42
2.82
29.1
15.1
13.5
13.6
%
1.09
378
3425
44
268
1.70
2.67
3.3
3.1
190.7
163.3
ng/l
0.27
36
240
438
4096
1.53
2.66
5.5
4.3
5.9
5.9
mmol/l
0.30
407
3773
30
166
1.86
2.51
16.2
11.7
24.3
24.4
mmol/l
0.08
30
158
289
2537
1.33
2.50
4.5
3.9
231.2
225.2
e6/l
—
6
35
446
4214
1.51
2.28
4.7
4.2
4.5
4.7
mmol/l
4.51
420
3933
6
13
4.66
2.27
3.5
3.0
—
—
—
0
0
6
13
4.66
2.27
1.0
1.8
201.7
198.3
u/l
—
6
13
38
233
1.68
2.27
1.9
1.5
—
—
—
0
0
471
4509
1.68
2.22
15.8
9.7
32.8
27.9
u/l
5.48
465
4361
82
603
1.43
2.20
2.8
2.7
3.8
1.8
e6/l
0.71
41
331
18
87
2.11
2.19
1.3
1.2
302.4
284.0
u/ml
—
7
52
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
88
2.08
2.14
3.4
2.5
0.3
0.3
u/ml
—
7
45
13
55
2.40
2.14
1.2
1.1
—
—
—
0
0
19
95
2.04
2.13
5.1
1.6
—
—
—
0
0
29
168
1.77
2.12
2.0
1.7
33.4
39.8
nmol/l
1.55
29
163
8
26
3.11
2.02
1.6
2.1
—
—
—
0
0
290
2594
1.28
1.97
3.3
2.9
—
—
—
0
0
429
4048
1.40
1.96
4.2
3.7
1.4
1.3
mmol/l
0.66
398
3746
214
1845
1.28
1.96
5.5
3.9
—
—
—
0
0
450
4283
1.47
1.96
5.3
4.6
2.7
2.8
mmol/l
2.99
419
3973
442
4197
1.43
1.91
4.7
4.1
1.4
1.5
mmol/l
4.71
412
3892
23
132
1.78
1.77
1.3
2.0
11.9
10.7
g/l
0.58
18
116
44
300
1.51
1.75
8.0
2.9
2.0
2.4
mmol/l
0.22
38
241
68
505
1.40
1.74
4.2
4.0
31.0
31.4
%
0.12
54
349
38
252
1.55
1.71
1.2
1.3
329.9
129.3
iu/ml
0.77
13
108
409
3853
1.33
1.71
24.3
13.0
41.2
40.8
%
0.37
280
2860
24
143
1.71
1.64
1.3
2.0
7.3
7.3
g/l
0.00
16
115
24
143
1.71
1.64
1.3
2.0
4.4
3.9
g/l
0.70
16
111
24
143
1.71
1.64
1.3
2.0
—
—
—
0
0
5
14
3.60
1.62
1.0
1.7
—
—
—
0
0
13
63
2.09
1.61
1.4
1.3
6.7
4.0
u/ml
—
6
29
21
122
1.75
1.57
1.0
1.4
174.0
207.5
miu/ml
—
5
61
5
15
3.36
1.52
1.2
1.0
—
—
—
0
0
18
101
1.81
1.51
1.4
1.2
—
—
—
0
0
9
37
2.46
1.48
1.1
1.3
—
—
—
0
0
25
156
1.63
1.46
2.3
1.9
2.2
3.3
ug/l
0.22
25
139
5
16
3.15
1.44
1.0
1.4
—
—
—
0
0
134
1131
1.25
1.40
1.6
1.6
1.5
1.4
mmol/l
0.35
100
959
14
74
1.92
1.40
1.1
1.2
—
—
—
0
0
6
23
2.63
1.37
2.0
2.3
—
—
—
0
0
6
23
2.63
1.37
1.7
1.5
—
—
—
0
0
9
42
2.16
1.34
1.1
1.1
—
—
—
0
0
82
655
1.30
1.34
2.6
2.5
0.8
1.0
e6/l
0.38
41
384
22
137
1.63
1.31
1.3
2.0
2.8
3.2
g/l
0.81
16
112
6
24
2.52
1.30
1.2
2.6
724.2
1786.1
u/ml
—
6
24
6
24
2.52
1.30
1.2
1.0
—
—
—
0
0
8
34
2.37
1.29
1.4
1.1
—
—
—
0
0
8
34
2.37
1.29
1.4
1.1
—
—
—
0
0
5
18
2.79
1.29
1.2
1.1
1586.2
1663.0
miu/ml
—
5
18
10
48
2.11
1.28
1.4
1.4
44.1
29.1
u/l
—
10
41
15
84
1.81
1.28
4.0
2.2
139.6
130.6
g/l
—
10
65
18
107
1.71
1.27
1.6
3.7
—
2.3
—
0
13
8
35
2.31
1.27
1.4
1.1
—
—
—
0
0
8
35
2.31
1.27
1.4
1.1
—
—
—
0
0
8
35
2.31
1.27
1.4
1.1
—
—
—
0
0
8
37
2.18
1.22
1.1
1.2
—
—
—
0
0
8
38
2.12
1.19
1.0
1.1
—
—
—
0
0
0
33
0.00
1.16
0.0
1.0
—
—
—
0
0
0
33
0.00
1.16
0.0
1.0
—
—
—
0
0
8
39
2.07
1.15
1.5
1.2
—
—
—
0
0
7
30
2.35
1.12
1.3
1.1
—
—
—
0
0
8
40
2.02
1.12
2.5
1.3
—
—
—
0
0
16
96
1.69
1.11
1.1
1.2
—
—
—
0
0
5
21
2.39
1.09
1.0
1.2
184.0
138.2
iu/ml
—
5
21
17
105
1.64
1.07
1.8
1.7
—
—
—
0
0
14
82
1.73
1.06
2.4
2.4
4.4
939.7
u/l
—
6
29
7
33
2.14
1.06
1.4
1.6
—
—
—
0
0
9
46
1.97
1.04
1.2
1.4
—
—
—
0
0
5
22
2.28
1.03
1.4
3.7
64.4
61.9
nmol/l
—
5
22
82
679
1.25
1.02
1.5
1.4
—
—
—
0
0
11
61
1.82
0.99
1.8
1.6
—
—
—
0
0
9
50
1.81
0.97
1.3
1.7
—
—
—
0
0
13
78
1.68
0.92
4.0
2.3
15.8
16.3
%
—
8
43
81
679
1.23
0.92
3.7
3.4
1367.4
472.9
ng/l
0.43
56
512
11
64
1.73
0.86
1.0
1.1
—
—
—
0
0
8
45
1.79
0.84
1.1
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
16
107
1.51
0.77
1.3
1.1
—
—
—
0
0
49
398
1.26
0.75
2.6
4.8
3.1
33.5
ug/l
0.88
38
327
5
25
2.01
0.73
1.0
6.1
—
33.5
—
0
6
13
85
1.54
0.69
1.1
1.3
2.5
7.1
e6/l
—
6
69
13
85
1.54
0.69
1.1
1.3
82.6
1385.2
e6/l
—
8
71
7
42
1.68
0.68
9.9
3.7
—
—
—
0
0
5
28
1.79
0.66
2.4
1.5
0.8
1.0
g/l
—
5
28
10
62
1.63
0.65
1.3
1.0
—
—
—
0
0
7
44
1.60
0.65
1.6
3.1
1.7
2.8
nmol/l
—
7
44
105
933
1.16
0.65
2.8
2.2
—
—
—
0
0
5
29
1.73
0.64
2.0
2.0
0.2
0.2
e9/l
—
5
24
11
71
1.56
0.62
1.6
1.2
—
—
—
0
0
11
71
1.56
0.62
1.6
1.2
—
—
—
0
0
15
105
1.44
0.60
1.9
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
23
175
1.33
0.59
3.2
1.9
1.3
1.3
%
0.05
23
175
8
54
1.49
0.57
1.1
1.1
—
—
—
0
0
12
81
1.49
0.57
1.5
1.2
—
—
—
0
0
6
36
1.67
0.57
1.0
1.0
—
—
—
0
0
128
1401
0.88
0.56
3.7
4.1
22.4
21.2
%
0.39
47
667
11
76
1.46
0.48
1.4
1.8
—
—
—
0
0
13
176
0.73
0.46
2.5
2.1
—
—
—
0
0
19
147
1.30
0.46
2.0
2.9
24.3
24.8
mmol/l
0.75
19
141
5
31
1.62
0.43
2.0
1.9
500.2
505.8
e6/l
—
5
24
6
92
0.65
0.42
1.2
1.3
—
—
—
0
0
66
588
1.14
0.42
2.2
1.8
—
—
—
0
0
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
47
411
1.16
0.39
2.0
1.7
—
—
—
0
0
26
215
1.22
0.39
1.4
1.4
—
—
—
0
0
10
136
0.73
0.38
2.8
2.1
—
—
—
0
0
47
413
1.15
0.37
2.2
1.8
—
—
—
0
0
41
358
1.16
0.35
6.6
2.4
27.2
33.0
u/l
1.05
30
311
6
44
1.37
0.34
2.0
1.9
—
—
—
0
0
40
350
1.16
0.34
1.9
1.8
—
—
—
0
0
44
388
1.15
0.34
2.0
1.9
—
—
—
0
0
37
323
1.16
0.32
3.2
2.4
66.3
69.6
ml/min/173m2
0.23
19
121
15
119
1.27
0.32
1.1
1.1
—
—
—
0
0
17
207
0.82
0.30
2.0
1.5
—
—
—
0
0
12
93
1.30
0.30
1.3
1.2
—
—
—
0
0
7
57
1.23
0.29
3.4
1.8
12.9
13.1
%
—
7
57
475
4707
1.16
0.28
35.1
18.2
141.4
138.2
g/l
4.08
470
4639
10
78
1.29
0.24
1.3
1.6
—
—
—
0
0
5
40
1.25
0.22
1.2
1.7
—
—
—
0
0
5
40
1.25
0.22
1.2
1.7
—
—
—
0
0
5
40
1.25
0.22
1.2
1.7
—
—
—
0
0
10
124
0.80
0.22
1.8
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
6
48
1.25
0.20
2.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
9
113
0.79
0.20
1.9
1.7
—
—
—
0
0
8
69
1.16
0.16
1.5
1.4
—
—
—
0
0
8
69
1.16
0.16
1.5
1.4
—
—
—
0
0
8
69
1.16
0.16
1.5
1.4
—
—
—
0
0
14
120
1.17
0.16
1.4
1.7
—
—
—
0
0
13
111
1.18
0.16
1.8
1.5
—
—
—
0
0
14
121
1.16
0.15
1.1
1.1
—
—
—
0
0
177
1723
1.04
0.15
4.1
4.6
2.1
2.4
ug/l
0.39
154
1561
10
117
0.85
0.13
1.2
1.5
—
—
—
0
0
11
95
1.16
0.11
1.6
1.5
—
—
—
0
0
22
203
1.09
0.09
2.9
2.5
1.2
0.1
e6/l
0.49
22
196
5
47
1.06
0.09
3.4
1.7
—
—
—
0
0
13
144
0.90
0.08
5.3
2.8
—
—
—
0
0
7
68
1.03
0.08
2.1
1.6
—
—
—
0
0
47
489
0.96
0.07
8.0
6.1
—
—
—
0
0
8
75
1.07
0.07
1.9
1.5
—
—
—
0
0
54
523
1.04
0.06
1.6
1.5
—
—
—
0
0
102
1038
0.98
0.05
2.8
3.0
0.7
0.7
ug/l
0.21
61
676
46
446
1.03
0.05
1.6
1.7
—
—
—
0
0
21
201
1.05
0.03
1.1
1.3
—
—
—
0
0
87
861
1.01
0.01
3.7
3.4
1.0
1.0
kg/l
0.57
12
113
14
134
1.05
0.00
1.6
1.7
—
—
—
0
0
14
146
0.96
0.00
1.9
1.9
—
—
—
0
0
12
124
0.97
0.00
1.4
1.3
—
—
—
0
0
16
156
1.03
0.00
2.7
1.5
—
—
—
0
0
20
202
0.99
0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
6
65
0.92
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
0.00
2.0
1.6
—
—
—
0
0
7
72
0.97
0.00
1.6
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
90.3
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.8
1.5
—
—
—
0
0
7
72
0.97
0.00
1.9
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_IRON_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_IRON_MET | 1.819 [1.37, 2.42] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.43 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 700 females with E4_IRON_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_IRON_MET | 2.068 [1.7, 2.51] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 1047 males with E4_IRON_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_IRON_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.41% |
| 5 | 1.129% | 2.443% |
| 10 | 2.835% | 6.134% |
| 15 | 5.252% | 11.96% |
| 20 | 8.954% | 19.321% |
Relationships between endpoints
↥Index endpoint: E4_IRON_MET – Disorders of iron metabolism
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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