No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
579 |
4. Check minimum number of eventsNone |
579 |
5. Include endpointsNone |
579 |
6. Filter based on genotype QC (FinnGen only) |
579 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis non specificata
Similar endpoints
↥List of similar endpoints to
Thyroiditis, unspecified
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4136 | 3328 | 780 |
| Only index persons | 3597 | 2934 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.92 | 43.41 | 45.87 |
| Only index persons | 42.03 | 41.65 | 43.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 579 | 481 | 98 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.04 |
| Median age at first event (years) | 40.68 | 40.11 | 43.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 528
- Matched controls
- 5279
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.9
ICD-10 Finland
Thyroiditis, unspecified
9715.9
323.0
371
*
H03AA01
ATC
levothyroxine sodium; systemic
88.2
264.0
287
70
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
208.7
150.5
150
10
104
Kela drug reimbursment
Thyroid insufficiency
336.8
131.6
128
5
24509
ICD-8 Finland
Thyroiditis, Unspecified
+∞
110.4
102
*
H03BB01
ATC
carbimazole; oral
235.1
79.7
80
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
68.2
64
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
685.6
63.2
61
*
2459X
ICD-9 Finland
Thyroiditis, unspecified
+∞
57.3
54
*
E03
ICD-10 Finland
Other hypothyroidism
68.0
48.3
55
9
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
452.3
42.8
42
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
440.5
41.7
41
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
210.1
38.3
39
*
T86
ICPC
Hypothyroidism/myxoedema
67.9
28.3
32
5
E06.3
ICD-10 Finland
Autoimmune thyroiditis
76.4
26.0
29
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
36.5
24.5
31
9
BAA60
NOMESCO Finland
Total thyroidectomy
131.0
23.8
25
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
22.0
21
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
24.8
18.8
26
11
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
40.0
18.7
23
6
C07AA05
ATC
propranolol; systemic
2.8
18.5
139
597
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
98.4
17.7
19
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
17.1
53
108
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
16.8
16
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
23.0
14.3
20
9
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
14.1
216
1299
H02AB06
ATC
prednisolone; systemic
2.1
14.1
263
1718
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
71.6
12.6
14
*
A02BC02
ATC
pantoprazole; systemic
1.9
11.0
341
2592
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
112.2
10.5
11
*
E06
ICD-10 Finland
Thyroiditis
112.2
10.5
11
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
10.2
141
794
H02AB07
ATC
prednisone; oral
2.4
10.2
95
449
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
101.8
9.4
10
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
9.0
69
293
N03AX16
ATC
pregabalin; oral
2.0
8.5
129
746
R53
ICD-10 Finland
Malaise and fatigue
2.1
8.4
104
554
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
8.4
8
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
+∞
8.4
8
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
9.7
8.3
16
17
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
8.2
98
515
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
8.1
94
486
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.9
126
742
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.7
206
1434
J01DB01
ATC
cefalexin; oral
1.8
7.6
426
3663
C07AB07
ATC
bisoprolol; oral
1.7
7.5
211
1483
E05.89
ICD-10 Finland
Other thyrotoxicosis
81.2
7.4
8
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
+∞
7.3
7
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
7.3
7
*
M54.5
ICD-10 Finland
Low back pain
1.7
7.2
175
1178
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
7.2
93
502
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
30.5
7.2
9
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
30.5
7.2
9
*
A02BC03
ATC
lansoprazole; oral
1.8
7.1
152
983
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
7.0
90
484
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
7.0
25
62
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
6.8
22
49
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
6.8
171
1157
UJF32
NOMESCO Finland
Coloscopy
1.8
6.6
124
768
A02BC05
ATC
esomeprazole; systemic
1.6
6.5
210
1520
M79.6
ICD-10 Finland
Pain in limb
1.7
6.5
181
1260
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
70.7
6.4
7
*
J01DA01
ATC
[U] cefalexin; systemic
1.6
6.3
329
2683
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.3
106
632
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
6.3
6
*
2504
FHL
Unilateral resection or enucleation
+∞
6.3
6
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
6.3
127
804
G44.2
ICD-10 Finland
Tension-type headache
2.0
6.2
79
426
UKC02
NOMESCO Finland
Cystoscopy
2.2
6.2
64
314
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
4.0
6.2
23
60
N03AX12
ATC
gabapentin; oral
2.0
6.2
80
433
A04
ICPC
Weakness/tiredness general
2.1
6.2
70
358
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.7
6.1
10
8
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.07 [0.88, 1.3] | 0.502 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 1872 females with E4_THYROIDITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.031 [0.79, 1.35] | 0.827 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 435 males with E4_THYROIDITNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.199% |
| 5 | 0.55% | 1.133% |
| 10 | 1.31% | 2.965% |
| 15 | 2.674% | 5.73% |
| 20 | 4.741% | 9.773% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITNAS – Thyroiditis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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