No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
591 |
4. Check minimum number of eventsNone |
591 |
5. Include endpointsNone |
591 |
6. Filter based on genotype QC (FinnGen only) |
569 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis non specificata
Similar endpoints
↥List of similar endpoints to
Thyroiditis, unspecified
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4136 | 3328 | 780 |
| Only index persons | 3597 | 2934 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.92 | 43.41 | 45.87 |
| Only index persons | 42.03 | 41.65 | 43.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 569 | 474 | 95 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.04 |
| Median age at first event (years) | 41.31 | 40.82 | 43.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 591
- Matched controls
- 5910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
163.9
307.7
182
16
H03AA01
ATC
levothyroxine sodium; systemic
97.7
307.7
329
75
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
307.7
426
*
104
Kela drug reimbursment
Thyroid insufficiency
445.0
141.3
136
*
24509
ICD-8 Finland
Thyroiditis, Unspecified
+∞
116.6
108
*
H03BB01
ATC
carbimazole; oral
237.2
98.8
99
5
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
82.2
77
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
204.5
70.8
72
*
E03
ICD-10 Finland
Other hypothyroidism
188.5
65.5
67
*
2459X
ICD-9 Finland
Thyroiditis, unspecified
+∞
59.4
56
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
145.2
50.7
53
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
530.6
50.2
49
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
231.4
42.5
43
*
T86
ICPC
Hypothyroidism/myxoedema
69.4
34.4
39
6
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
78.6
33.2
37
5
E06.3
ICD-10 Finland
Autoimmune thyroiditis
168.8
31.0
32
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
29.4
28
*
BAA60
NOMESCO Finland
Total thyroidectomy
157.7
28.9
30
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.0
25.6
58
126
C07AA05
ATC
propranolol; systemic
2.5
20.7
169
815
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
43.3
20.6
25
6
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
21.0
20.6
30
15
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
19.9
19
*
H02AB06
ATC
prednisolone; systemic
2.2
18.6
308
1979
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
31.2
18.5
24
8
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
54.3
18.1
21
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
17.2
255
1557
H02AB07
ATC
prednisone; oral
2.6
16.5
106
452
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
24.1
15.2
21
9
E06
ICD-10 Finland
Thyroiditis
+∞
13.6
13
*
A04
ICPC
Weakness/tiredness general
2.4
13.0
100
462
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
12.7
176
1028
A02BC02
ATC
pantoprazole; systemic
2.0
12.4
410
3175
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
10.7
125
680
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
111.9
10.5
11
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
10.4
10
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
10.4
31
83
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
9.0
10.3
21
24
C07AB07
ATC
bisoprolol; oral
1.8
10.1
258
1803
A02BC05
ATC
esomeprazole; systemic
1.7
9.5
250
1755
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
101.6
9.4
10
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
9.4
9
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
9.2
87
436
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.7
156
974
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
8.6
85
433
T85
ICPC
Hyperthyroidism/thyrotoxicosis
91.3
8.4
9
*
N03AX16
ATC
[U] pregabalin
1.8
8.4
147
911
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
8.4
159
1009
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
8.3
8
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
8.3
8
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
8.3
96
519
R52.9
ICD-10 Finland
Pain, unspecified
2.3
8.3
64
295
M54.5
ICD-10 Finland
Low back pain
1.7
8.2
220
1537
UJF32
NOMESCO Finland
Coloscopy
1.8
8.1
146
913
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
11.0
7.8
14
13
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.8
243
1761
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
45.6
7.7
9
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
7.7
108
623
UKC02
NOMESCO Finland
Cystoscopy
2.1
7.6
72
360
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
81.1
7.4
8
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
7.4
114
676
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
7.3
7
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
7.3
7
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
7.3
7
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
7.2
118
714
N06AX11
ATC
mirtazapine; oral
1.6
7.1
200
1403
R53
ICD-10 Finland
Malaise and fatigue
1.7
7.1
143
918
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.2
7.1
27
86
BA1AE, ,
SPAT
10.2
7.1
13
13
D02
ICPC
Abdominal pain epigastric
2.5
7.0
45
190
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.0
69
350
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.0
235
1721
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
7.0
72
372
XF404
NOMESCO Finland
Ambulatory ECG
2.3
7.0
52
236
R06AX27
ATC
desloratadine; oral
1.7
6.9
183
1263
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.9
193
1353
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
6.8
155
1027
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.8
96
553
A10AB01
ATC
insulin (human); parenteral
3.3
6.8
25
78
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
40.5
6.8
8
*
M79.6
ICD-10 Finland
Pain in limb
1.6
6.7
250
1871
A02BC01
ATC
omeprazole; systemic
1.7
6.6
157
1053
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.6
125
788
A02BA02
ATC
ranitidine; systemic
1.8
6.6
111
677
D11
ICPC
Diarrhoea
2.0
6.4
77
420
R51.80
ICD-10 Finland
Headache
1.8
6.4
104
626
A10AB04
ATC
insulin lispro; parenteral
3.3
6.3
23
71
R60.0
ICD-10 Finland
Localized oedema
2.0
6.3
68
357
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.6
6.3
36
144
SPAT1262
SPAT
Handing over of treatment supplies
1.9
6.3
86
490
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.9
6.3
18
47
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.3
207
1502
J01DB01
ATC
cefalexin; oral
1.7
6.2
480
4224
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
27.0
6.2
8
*
H92.0
ICD-10 Finland
Otalgia
2.4
6.2
42
182
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
12.7
6.1
10
8
R03AC02
ATC
salbutamol; inhalant
1.5
6.1
327
2639
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
154
141
14.42
151.25
4.0
1.4
4.44
4.50
pmol/l
0.17
138
124
98
59
19.71
120.26
2.4
1.2
2.26
1.25
iu/l
1.92
35
12
141
258
6.86
77.59
1.6
1.1
251.32
69.31
iu/ml
4.38
67
75
525
3678
4.83
37.08
8.7
2.5
15.28
14.31
pmol/l
13.39
497
3355
540
4488
3.35
16.70
10.0
3.4
1.83
1.84
mu/l
0.02
508
4132
355
2588
1.93
13.32
4.9
4.1
6.65
6.50
mmol/l
0.69
338
2394
284
1939
1.89
12.88
5.9
4.8
1.22
1.22
mmol/l
0.46
257
1776
370
2764
1.91
12.55
9.2
8.4
4.15
4.05
e9/l
0.34
331
2404
323
2312
1.88
12.51
6.5
5.3
28.72
28.61
%
0.06
298
2169
284
1965
1.86
12.12
2.6
2.2
78.83
77.07
nmol/l
0.48
254
1784
278
1922
1.84
11.80
15.3
11.5
1.22
1.17
inr
0.31
79
562
308
2199
1.84
11.76
3.5
2.6
108.76
90.62
ug/l
1.01
279
2037
444
3561
1.99
11.73
5.4
3.9
12.99
11.33
mm/h
1.47
417
3290
446
3605
1.97
11.21
7.7
6.6
78.71
76.10
u/l
0.27
423
3391
315
2289
1.81
11.12
6.3
5.1
56.04
57.00
%
0.72
292
2146
176
1070
1.92
11.04
2.4
2.1
2.81
2.98
mg/l
0.43
151
918
300
2153
1.80
11.01
6.8
5.6
1.22
1.22
mmol/l
0.03
253
1839
234
1602
1.76
9.76
4.7
3.2
27.96
30.84
ng/l
0.18
142
982
114
622
2.03
9.65
2.6
2.1
12.76
13.34
umol/l
0.35
101
574
78
369
2.28
9.48
2.2
1.8
369.29
375.94
nmol/l
0.11
66
338
172
1091
1.81
9.20
2.2
1.7
0.85
1.01
mg/l
0.64
129
819
219
1509
1.72
8.70
2.4
3.3
2.34
2.36
mmol/l
1.47
181
1348
314
2387
1.67
8.57
5.5
5.4
9.56
10.63
umol/l
1.01
295
2260
393
3171
1.71
8.54
5.7
4.2
4429.57
4413.12
e6/l
—
7
43
242
1721
1.69
8.50
2.1
1.9
97.99
94.55
pmol/l
0.45
124
870
31
96
3.35
8.46
1.3
1.2
—
—
—
0
0
44
169
2.73
8.31
1.7
2.1
—
—
—
0
0
191
1283
1.72
8.23
2.4
2.0
142.31
170.39
u/l
0.42
182
1222
102
572
1.95
7.90
2.5
2.1
2.36
2.37
g/l
0.08
88
527
165
1081
1.73
7.71
3.4
2.7
2203.42
960.84
ng/l
1.64
136
909
172
1141
1.72
7.68
1.4
1.3
0.76
1.95
u/ml
1.47
37
296
542
4910
2.25
7.13
19.1
12.8
139.48
139.68
mmol/l
1.13
536
4770
543
4923
2.27
7.12
19.0
12.9
3.93
3.94
mmol/l
0.21
536
4763
538
4882
2.14
6.67
18.6
11.7
20.34
22.18
mg/l
0.70
448
3777
92
529
1.88
6.57
2.6
2.2
21.08
22.67
%
0.44
70
458
194
1395
1.58
6.07
3.0
2.2
55.95
62.00
u/l
0.59
181
1285
60
306
2.07
6.04
3.0
3.3
100.49
74.98
ng/l
0.96
55
270
158
1101
1.59
5.58
2.1
2.3
327.35
6440.27
umol/l
4.67
136
980
112
717
1.69
5.53
1.8
1.7
1180.57
1198.97
nmol/l
0.07
94
538
133
894
1.63
5.44
1.4
1.3
7.59
9.52
u/ml
0.19
62
354
124
819
1.65
5.43
4.7
3.3
60.96
320.87
ng/l
2.24
82
584
58
305
2.00
5.38
3.0
2.8
147.32
152.96
ng/l
0.05
53
280
206
1536
1.52
5.36
3.3
3.0
30.24
30.41
u/l
0.04
198
1467
28
109
2.65
5.21
2.8
2.4
—
—
—
0
0
239
1853
1.49
5.09
4.1
4.1
35.22
35.97
g/l
1.34
220
1731
137
943
1.59
5.05
1.4
1.3
21.26
31.90
iu/ml
1.28
51
301
145
1017
1.56
4.92
4.4
3.7
1.01
1.02
kg/l
1.15
28
136
32
138
2.39
4.84
1.8
1.5
0.01
0.11
iu/ml
—
8
30
295
2422
1.44
4.49
4.2
3.4
0.00
0.01
estimate
0.80
49
427
552
5172
2.02
4.46
11.9
9.1
24.78
24.39
u/l
0.28
536
4998
291
2389
1.43
4.40
4.1
3.5
0.00
0.00
estimate
-0.00
54
465
100
662
1.61
4.30
3.3
2.8
0.84
0.81
mmol/l
1.82
94
628
71
430
1.74
4.27
2.3
2.1
28.98
33.59
u/l
0.80
58
355
497
4542
1.59
4.14
14.6
10.9
83.50
84.07
ml/min/173m2
0.22
421
3659
128
906
1.53
4.11
2.6
2.4
10.17
6.60
e6/l
0.57
114
805
54
305
1.85
4.09
7.1
5.8
10.88
8.29
mmol/l
1.64
54
291
41
211
2.01
4.07
3.7
3.7
3.38
1.93
mmol/l
0.92
33
156
506
4649
1.61
4.06
4.8
4.1
5.86
5.79
mmol/l
0.51
461
4268
52
294
1.84
3.93
1.4
1.5
—
—
—
0
0
175
1331
1.45
3.92
3.3
2.9
50.45
120.91
e6/l
0.63
137
991
371
3219
1.41
3.89
3.4
2.9
42.84
41.71
u/l
0.12
352
3026
288
2395
1.39
3.87
5.8
4.7
0.00
0.00
estimate
0.50
49
434
101
690
1.56
3.79
2.0
1.8
—
—
—
0
0
16
55
2.96
3.76
1.2
1.2
—
—
—
0
0
156
1169
1.45
3.76
4.4
3.4
97.10
95.38
%
0.39
151
1140
160
1209
1.44
3.68
3.5
3.7
11.45
9.32
mg/mmol
0.19
105
754
477
4352
1.50
3.67
6.1
4.9
39.92
38.88
mmol/mol
1.35
431
4067
16
56
2.91
3.65
1.2
1.2
—
—
—
0
0
16
56
2.91
3.65
1.2
1.2
—
—
—
0
0
45
250
1.87
3.61
1.5
1.7
—
—
—
0
0
135
992
1.47
3.58
1.8
1.5
—
—
—
0
0
16
57
2.86
3.55
1.2
1.2
—
—
—
0
0
16
57
2.86
3.55
1.1
1.2
—
—
—
0
0
22
93
2.42
3.52
1.3
1.2
—
—
—
0
0
28
132
2.18
3.51
1.3
1.2
5.30
3.38
u/ml
—
6
17
10
22
4.60
3.44
3.0
4.3
885.60
631.00
u/ml
—
10
22
68
433
1.64
3.42
2.7
4.0
240.79
237.37
u/l
0.09
63
408
32
161
2.04
3.41
2.1
1.9
1.76
1.50
g/l
0.67
26
141
28
134
2.14
3.39
1.3
1.2
9.82
6.50
u/ml
—
6
27
33
169
2.01
3.36
1.5
1.7
—
—
—
0
0
513
4788
1.54
3.17
4.7
4.0
4.73
4.81
mmol/l
0.98
472
4481
511
4768
1.53
3.14
4.7
3.9
1.50
1.55
mmol/l
2.06
464
4444
385
3426
1.36
3.07
3.7
3.3
—
—
—
0
0
32
169
1.94
3.01
2.3
1.8
—
—
—
0
0
146
1122
1.40
3.00
2.8
2.0
—
—
—
0
0
132
997
1.42
2.99
1.7
1.5
17.63
22.17
nmol/l
3.36
105
847
15
57
2.67
2.98
1.1
1.2
—
—
—
0
0
155
1208
1.38
2.93
3.2
2.8
0.23
0.49
e6/l
1.84
120
886
161
1263
1.38
2.92
2.9
3.0
6.89
7.21
mmol/l
0.33
135
1091
17
70
2.47
2.90
1.8
1.7
—
—
—
0
0
223
1845
1.34
2.86
4.3
3.6
—
—
—
0
0
120
899
1.42
2.84
1.7
1.6
422.48
41799372.67
pmol/l
1.58
94
756
29
155
1.92
2.66
2.2
1.7
—
—
—
0
0
28
148
1.94
2.65
1.6
1.8
0.90
2.86
ug/l
0.51
23
136
12
41
2.97
2.63
1.2
1.1
—
—
—
0
0
12
41
2.97
2.63
1.2
1.1
—
—
—
0
0
37
215
1.77
2.62
1.8
1.8
3.37
3.04
mg/l
0.13
26
157
263
2248
1.31
2.62
2.9
2.4
—
—
—
0
0
12
42
2.89
2.56
1.2
1.1
—
—
—
0
0
12
42
2.89
2.56
1.2
1.1
—
—
—
0
0
12
42
2.89
2.56
1.2
1.1
—
—
—
0
0
568
5484
1.92
2.49
27.3
17.4
4.43
4.45
e12/l
0.38
559
5330
489
4577
1.40
2.44
4.2
3.6
1.30
1.23
mmol/l
1.16
446
4240
69
479
1.50
2.43
1.7
1.7
—
—
—
0
0
567
5478
1.86
2.38
27.4
17.4
263.26
258.09
e9/l
1.05
558
5343
515
4871
1.45
2.35
5.2
4.4
2.77
2.84
mmol/l
1.03
471
4535
49
319
1.58
2.30
2.0
2.6
66.01
67.67
g/l
0.76
42
294
90
667
1.41
2.27
3.0
2.6
4.42
3.49
e6/l
0.24
47
329
566
5474
1.80
2.24
27.2
17.4
39.45
39.67
%
0.39
533
5145
48
317
1.56
2.14
2.1
2.2
3.44
5.62
ug/l
1.86
38
279
66
469
1.46
2.09
5.6
5.7
104.00
104.41
mmol/l
0.28
66
469
9
31
2.93
2.08
1.1
1.1
—
—
—
0
0
27
154
1.79
2.07
1.3
1.7
9.91
10.53
g/l
0.34
22
142
5
10
5.03
2.07
1.2
1.1
103.00
101.30
%
—
5
10
72
524
1.43
2.02
4.6
4.0
33.23
32.78
%
0.12
53
357
28
164
1.74
1.98
1.3
1.7
—
—
—
0
0
28
164
1.74
1.98
1.3
1.7
7.30
7.50
g/l
0.21
23
153
28
164
1.74
1.98
1.3
1.7
3.62
3.67
g/l
0.09
23
153
103
801
1.35
1.95
2.3
2.7
2.42
2.45
mmol/l
1.87
91
709
67
487
1.42
1.90
1.8
1.8
—
—
—
0
0
93
715
1.36
1.89
3.0
2.4
1.07
1.23
e6/l
0.26
51
376
36
229
1.61
1.89
10.2
7.3
25.51
24.64
mmol/l
0.99
36
217
152
1256
1.28
1.86
4.6
3.7
0.00
0.00
estimate
0.80
48
430
70
516
1.40
1.84
6.7
6.1
—
—
—
0
0
19
101
1.91
1.82
1.2
1.1
0.92
2.87
u/ml
—
8
48
7
23
3.07
1.80
1.1
1.1
—
—
—
0
0
8
29
2.78
1.79
1.4
1.1
—
—
—
0
0
8
30
2.69
1.73
1.1
1.9
22.54
21.36
nmol/l
—
8
30
30
187
1.64
1.72
5.4
3.0
24.35
24.05
mmol/l
0.20
30
182
23
134
1.75
1.68
1.3
1.7
39.58
38.08
g/l
0.46
18
123
16
83
1.95
1.66
1.1
1.3
—
—
—
0
0
68
509
1.38
1.65
2.7
2.7
5.73
6.38
umol/l
0.26
55
431
24
143
1.71
1.63
1.3
1.9
0.00
0.97
g/l
1.84
19
130
6
20
3.02
1.58
1.7
1.2
—
—
—
0
0
6
20
3.02
1.58
1.7
1.2
—
—
—
0
0
5
15
3.35
1.52
1.2
1.3
88.72
229.22
iu/ml
—
5
15
25
154
1.65
1.52
1.3
1.7
3.17
2.97
g/l
0.24
20
143
16
86
1.88
1.51
1.6
1.2
5.00
3.03
u/ml
—
7
32
6
21
2.88
1.51
1.0
1.0
—
—
—
0
0
23
140
1.67
1.47
1.7
1.3
—
—
—
0
0
9
38
2.39
1.46
2.0
2.0
—
—
—
0
0
49
356
1.41
1.43
7.4
7.1
120.37
119.74
g/l
0.08
49
347
35
238
1.50
1.43
2.5
2.0
1457.08
2768.90
u/l
0.57
18
100
59
443
1.37
1.42
6.6
6.5
1.87
1.28
mmol/l
0.86
51
351
15
81
1.87
1.41
1.3
1.4
—
—
—
0
0
15
81
1.87
1.41
1.3
1.4
—
—
—
0
0
13
68
1.93
1.34
1.5
1.1
—
—
—
0
0
18
107
1.70
1.27
1.7
1.3
—
—
—
0
0
16
92
1.76
1.26
2.1
2.7
4.16
6.21
umol/l
0.55
11
66
11
56
1.98
1.22
2.5
2.3
—
—
—
0
0
5
19
2.64
1.22
1.0
1.1
—
—
—
0
0
15
86
1.76
1.20
1.6
1.2
1.40
4.48
u/ml
—
5
25
10
50
2.02
1.17
1.1
1.1
—
—
—
0
0
36
258
1.42
1.16
1.3
1.5
—
—
—
0
0
8
39
2.07
1.15
1.3
1.3
—
—
—
0
0
46
348
1.35
1.10
3.3
3.2
1.21
1.23
mmol/l
1.58
36
310
12
66
1.84
1.09
1.3
1.2
—
—
—
0
0
33
240
1.40
1.01
3.5
2.7
132.27
127.60
g/l
0.54
33
234
19
123
1.56
1.00
1.4
3.1
—
2.43
—
0
13
144
1264
1.18
0.98
1.8
1.6
1.42
1.36
mmol/l
0.37
117
1079
16
100
1.62
0.97
4.6
3.5
21.25
29.62
mg/l
—
8
60
0
31
0.00
0.96
0.0
1.6
—
—
—
0
0
15
93
1.63
0.94
1.7
1.7
—
—
—
0
0
6
27
2.23
0.93
2.3
2.0
—
—
—
0
0
46
358
1.31
0.93
2.1
2.4
68.84
72.16
ml/min/173m2
0.19
19
134
9
52
1.74
0.92
3.8
3.6
—
—
—
0
0
17
112
1.53
0.85
1.4
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
12
74
1.63
0.78
1.2
1.5
—
—
—
0
0
12
74
1.63
0.78
1.2
1.5
—
—
—
0
0
22
157
1.42
0.77
1.2
1.1
—
—
—
0
0
9
54
1.68
0.74
1.3
1.4
—
—
—
0
0
9
54
1.68
0.74
1.3
1.4
—
—
—
0
0
10
160
0.62
0.74
1.4
1.5
—
—
—
0
0
14
92
1.53
0.73
2.1
1.8
3.72
4.73
mmol/24h
1.04
14
81
70
596
1.20
0.69
5.4
4.7
6.30
2.64
ug/l
0.42
64
535
7
42
1.67
0.68
1.6
1.8
8.34
8.02
mmol/l
—
7
42
14
94
1.50
0.67
2.3
2.2
137.50
131.58
g/l
—
8
65
19
137
1.40
0.65
1.3
1.3
—
—
—
0
0
5
29
1.73
0.64
1.0
1.2
—
—
—
0
0
21
155
1.37
0.64
1.2
1.1
—
—
—
0
0
50
417
1.22
0.62
1.8
1.8
—
—
—
0
0
15
105
1.44
0.60
1.3
1.6
—
—
—
0
0
53
448
1.20
0.58
3.5
3.0
—
—
—
0
0
8
53
1.52
0.58
1.1
1.1
—
—
—
0
0
40
330
1.23
0.56
1.2
1.4
31.28
30.28
iu/l
0.05
30
286
13
90
1.45
0.56
2.3
1.7
5926.38
13538.05
e6/l
—
8
63
64
554
1.17
0.55
1.5
1.8
1.41
1.40
%
0.06
56
494
57
490
1.18
0.53
1.7
1.7
—
—
—
0
0
12
83
1.46
0.52
1.7
1.6
—
—
—
0
0
7
45
1.56
0.49
1.3
1.2
—
—
—
0
0
25
199
1.27
0.48
1.3
1.3
145.36
246.53
miu/ml
0.83
14
102
7
49
1.43
0.46
1.1
1.7
—
—
—
0
0
16
121
1.33
0.44
1.4
1.5
553.88
484.06
mg/l
0.25
16
114
52
455
1.16
0.42
2.2
3.9
2.59
18.66
ug/l
1.01
37
363
5
33
1.52
0.41
1.2
1.7
0.18
1.13
promille
—
5
24
5
33
1.52
0.41
2.2
1.7
1.07
1.00
g/l
—
5
33
13
97
1.35
0.39
1.5
1.7
—
—
—
0
0
22
178
1.25
0.39
1.5
1.6
—
—
—
0
0
17
133
1.29
0.39
5.0
2.5
3.75
3.67
g/l
0.07
17
127
5
36
1.39
0.38
1.0
1.8
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
34
290
1.18
0.37
1.0
1.0
—
—
—
0
0
5
37
1.35
0.37
1.2
1.2
—
—
—
0
0
5
37
1.35
0.37
1.0
1.4
—
—
—
0
0
17
135
1.27
0.35
4.2
2.5
177.88
176.43
%
0.02
17
130
11
82
1.35
0.34
1.4
1.2
—
—
—
0
0
11
82
1.35
0.34
1.5
1.4
—
—
—
0
0
30
256
1.18
0.34
1.5
1.5
—
—
—
0
0
10
74
1.36
0.32
1.4
1.1
—
—
—
0
0
13
101
1.29
0.32
1.3
1.6
—
—
—
0
0
24
202
1.20
0.31
1.4
1.5
—
—
—
0
0
20
238
0.83
0.29
1.3
1.5
—
—
—
0
0
7
57
1.23
0.29
2.1
2.3
104.43
106.05
mmol/l
—
7
57
28
242
1.16
0.28
1.4
1.5
—
—
—
0
0
8
64
1.25
0.27
1.9
1.4
—
—
—
0
0
71
655
1.10
0.27
2.0
2.1
—
—
—
0
0
9
75
1.20
0.25
1.6
1.2
—
—
—
0
0
11
87
1.27
0.24
2.9
1.5
11.49
2.71
ug/l
0.39
11
77
10
78
1.29
0.24
1.2
1.1
—
—
—
0
0
52
477
1.10
0.23
4.5
4.1
18.02
21.31
%
1.09
25
221
5
39
1.28
0.23
1.2
1.4
—
—
—
0
0
38
343
1.12
0.22
1.5
1.5
—
—
—
0
0
5
40
1.25
0.22
1.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
1.20
—
0
10
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
8.20
—
0
8
12
144
0.83
0.20
2.0
1.6
—
—
—
0
0
7
61
1.15
0.17
1.1
1.5
—
—
—
0
0
7
61
1.15
0.17
1.1
1.2
16.28
14.85
u/l
—
7
55
8
72
1.11
0.16
1.1
1.6
—
—
—
0
0
13
111
1.18
0.16
2.1
1.5
—
—
—
0
0
18
159
1.14
0.15
7.1
4.8
1.89
1.54
%
0.56
18
148
63
596
1.06
0.15
1.7
2.0
—
—
—
0
0
13
113
1.15
0.13
1.2
1.4
193.71
320.33
ug/g
—
7
64
21
190
1.11
0.13
1.3
1.4
—
—
—
0
0
21
190
1.11
0.13
1.3
1.4
—
—
—
0
0
15
133
1.13
0.12
1.1
1.1
—
—
—
0
0
21
191
1.10
0.12
1.3
1.4
—
—
—
0
0
21
191
1.10
0.12
1.3
1.4
—
—
—
0
0
37
348
1.07
0.11
3.2
2.8
0.67
0.74
ug/l
0.41
27
226
34
320
1.07
0.10
1.6
1.6
—
—
—
0
0
11
124
0.88
0.09
2.5
3.6
1.35
1.43
mg/l
0.23
11
114
6
57
1.05
0.08
1.5
1.4
—
—
—
0
0
117
1144
1.03
0.08
1.5
1.4
—
—
—
0
0
7
68
1.03
0.08
1.4
1.4
—
—
—
0
0
6
70
0.86
0.07
1.3
1.4
7.18
7.29
mmol/l
—
6
57
28
293
0.95
0.05
1.6
1.4
—
—
—
0
0
13
124
1.05
0.00
1.7
1.5
—
—
—
0
0
20
194
1.03
0.00
3.5
1.8
—
—
—
0
0
11
111
0.99
0.00
1.2
1.8
17.00
7.76
e6/l
0.32
11
78
11
111
0.99
0.00
1.3
1.9
466.18
290.50
e6/l
0.15
11
84
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
2.9
1.9
13.10
13.24
%
—
7
73
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
54
0.93
-0.00
2.4
1.3
0.80
0.55
nmol/l
—
5
48
6
60
1.00
-0.00
1.3
1.5
—
—
—
0
0
5
54
0.93
-0.00
1.2
1.1
—
—
—
0
0
9
91
0.99
-0.00
3.8
3.3
59.67
57.58
%
—
9
91
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.07 [0.88, 1.3] | 0.502 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 1872 females with E4_THYROIDITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.031 [0.79, 1.35] | 0.827 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 435 males with E4_THYROIDITNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.199% |
| 5 | 0.55% | 1.133% |
| 10 | 1.31% | 2.965% |
| 15 | 2.674% | 5.73% |
| 20 | 4.741% | 9.773% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITNAS – Thyroiditis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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