No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
579 |
4. Check minimum number of eventsNone |
579 |
5. Include endpointsNone |
579 |
6. Filter based on genotype QC (FinnGen only) |
579 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis non specificata
Similar endpoints
↥List of similar endpoints to
Thyroiditis, unspecified
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4136 | 3328 | 780 |
| Only index persons | 3597 | 2934 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.92 | 43.41 | 45.87 |
| Only index persons | 42.03 | 41.65 | 43.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 579 | 481 | 98 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.04 |
| Median age at first event (years) | 40.68 | 40.11 | 43.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 528
- Matched controls
- 5279
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.9
ICD-10 Finland
Thyroiditis, unspecified
9715.9
323.0
371
*
H03AA01
ATC
levothyroxine sodium; systemic
88.2
264.0
287
70
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
208.7
150.5
150
10
104
Kela drug reimbursment
Thyroid insufficiency
336.8
131.6
128
5
24509
ICD-8 Finland
Thyroiditis, Unspecified
+∞
110.4
102
*
H03BB01
ATC
carbimazole; oral
235.1
79.7
80
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
68.2
64
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
685.6
63.2
61
*
2459X
ICD-9 Finland
Thyroiditis, unspecified
+∞
57.3
54
*
E03
ICD-10 Finland
Other hypothyroidism
68.0
48.3
55
9
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
452.3
42.8
42
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
440.5
41.7
41
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
210.1
38.3
39
*
T86
ICPC
Hypothyroidism/myxoedema
67.9
28.3
32
5
E06.3
ICD-10 Finland
Autoimmune thyroiditis
76.4
26.0
29
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
36.5
24.5
31
9
BAA60
NOMESCO Finland
Total thyroidectomy
131.0
23.8
25
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
22.0
21
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
24.8
18.8
26
11
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
40.0
18.7
23
6
C07AA05
ATC
propranolol; systemic
2.8
18.5
139
597
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
98.4
17.7
19
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
17.1
53
108
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
16.8
16
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
23.0
14.3
20
9
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
14.1
216
1299
H02AB06
ATC
prednisolone; systemic
2.1
14.1
263
1718
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
71.6
12.6
14
*
A02BC02
ATC
pantoprazole; systemic
1.9
11.0
341
2592
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
112.2
10.5
11
*
E06
ICD-10 Finland
Thyroiditis
112.2
10.5
11
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
10.2
141
794
H02AB07
ATC
prednisone; oral
2.4
10.2
95
449
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
101.8
9.4
10
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
9.0
69
293
N03AX16
ATC
pregabalin; oral
2.0
8.5
129
746
R53
ICD-10 Finland
Malaise and fatigue
2.1
8.4
104
554
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
8.4
8
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
+∞
8.4
8
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
9.7
8.3
16
17
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
8.2
98
515
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
8.1
94
486
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.9
126
742
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.7
206
1434
J01DB01
ATC
cefalexin; oral
1.8
7.6
426
3663
C07AB07
ATC
bisoprolol; oral
1.7
7.5
211
1483
E05.89
ICD-10 Finland
Other thyrotoxicosis
81.2
7.4
8
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
+∞
7.3
7
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
7.3
7
*
M54.5
ICD-10 Finland
Low back pain
1.7
7.2
175
1178
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
7.2
93
502
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
30.5
7.2
9
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
30.5
7.2
9
*
A02BC03
ATC
lansoprazole; oral
1.8
7.1
152
983
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
7.0
90
484
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.2
7.0
25
62
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
6.8
22
49
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
6.8
171
1157
UJF32
NOMESCO Finland
Coloscopy
1.8
6.6
124
768
A02BC05
ATC
esomeprazole; systemic
1.6
6.5
210
1520
M79.6
ICD-10 Finland
Pain in limb
1.7
6.5
181
1260
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
70.7
6.4
7
*
J01DA01
ATC
[U] cefalexin; systemic
1.6
6.3
329
2683
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.3
106
632
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
6.3
6
*
2504
FHL
Unilateral resection or enucleation
+∞
6.3
6
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
6.3
127
804
G44.2
ICD-10 Finland
Tension-type headache
2.0
6.2
79
426
UKC02
NOMESCO Finland
Cystoscopy
2.2
6.2
64
314
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
4.0
6.2
23
60
N03AX12
ATC
gabapentin; oral
2.0
6.2
80
433
A04
ICPC
Weakness/tiredness general
2.1
6.2
70
358
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.7
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
148
145
13.37
138.81
4.0
1.5
4.4
4.4
pmol/l
0.01
132
127
92
66
16.38
102.90
2.4
1.2
2.2
2.2
iu/l
0.01
32
13
135
270
6.22
67.45
1.6
1.1
258.9
79.4
iu/ml
4.12
65
80
514
3616
4.75
35.69
8.7
2.6
15.3
14.3
pmol/l
13.25
486
3300
529
4408
3.32
16.05
10.1
3.4
1.8
1.8
mu/l
0.01
496
4060
365
2709
1.94
12.93
9.4
8.5
4.2
4.1
e9/l
0.36
328
2352
348
2549
1.92
12.75
4.9
4.1
6.7
6.5
mmol/l
0.67
330
2353
282
1934
1.89
12.62
2.6
2.2
78.6
77.2
nmol/l
0.36
252
1754
304
2159
1.86
11.98
3.5
2.6
110.0
90.4
ug/l
1.12
275
1998
276
1908
1.85
11.80
6.1
4.8
1.2
1.2
mmol/l
0.65
251
1734
440
3539
2.01
11.60
7.8
6.6
78.8
76.3
u/l
0.26
417
3321
175
1050
1.96
11.54
2.4
2.1
2.8
3.0
mg/l
0.36
150
895
434
3504
1.95
10.90
5.4
3.9
13.1
11.3
mm/h
1.66
407
3240
292
2120
1.76
10.07
6.9
5.6
1.2
1.2
mmol/l
0.03
246
1794
114
617
2.06
9.90
2.6
2.1
12.8
13.4
umol/l
0.38
101
562
241
1691
1.73
9.11
2.1
1.9
97.6
94.5
pmol/l
0.39
123
851
310
2351
1.69
8.63
5.5
5.4
9.6
10.6
umol/l
1.02
292
2221
76
370
2.21
8.63
2.3
1.8
368.3
374.5
nmol/l
0.10
65
339
226
1582
1.70
8.47
4.7
3.2
28.8
28.7
ng/l
0.00
139
971
215
1488
1.71
8.38
2.4
3.3
2.3
2.4
mmol/l
1.54
173
1319
384
3105
1.70
8.20
5.7
4.2
4429.6
4513.5
e6/l
—
7
42
102
568
1.97
8.09
2.5
2.1
2.4
2.4
g/l
0.13
88
522
164
1062
1.76
8.06
3.4
2.7
2203.4
973.7
ng/l
1.62
136
897
166
1083
1.75
7.93
2.2
1.7
0.9
1.0
mg/l
0.52
123
809
43
169
2.67
7.78
1.8
2.1
—
—
—
0
0
169
1115
1.73
7.73
1.4
1.2
0.8
2.0
u/ml
1.44
35
283
188
1280
1.69
7.65
2.4
2.0
142.5
169.8
u/l
0.40
179
1219
30
99
3.14
7.42
1.3
1.2
—
—
—
0
0
532
4833
2.24
6.78
19.2
12.9
3.9
3.9
mmol/l
0.25
525
4676
92
524
1.90
6.78
2.7
2.2
21.0
22.5
%
0.41
69
453
531
4823
2.22
6.73
19.3
12.9
139.5
139.7
mmol/l
1.21
525
4684
113
704
1.75
6.20
1.9
1.7
1174.0
1195.8
nmol/l
0.08
95
530
526
4792
2.07
6.10
18.9
11.7
20.5
22.1
mg/l
0.60
438
3699
205
1503
1.56
5.89
3.3
3.0
30.2
30.5
u/l
0.08
197
1439
81
465
1.86
5.81
23.1
19.4
1.2
1.2
inr
0.05
14
62
189
1369
1.56
5.70
3.0
2.2
56.4
55.4
u/l
0.11
176
1259
58
300
2.04
5.63
3.0
2.8
147.3
155.2
ng/l
0.07
53
275
131
871
1.65
5.62
1.4
1.3
7.6
9.8
u/ml
0.22
62
343
28
105
2.75
5.58
2.8
2.4
—
—
—
0
0
156
1087
1.60
5.53
2.1
2.3
328.6
6575.0
umol/l
4.67
132
959
136
921
1.62
5.41
1.4
1.3
21.5
31.2
iu/ml
1.07
49
287
238
1829
1.51
5.41
4.1
4.0
35.3
36.0
g/l
1.17
220
1705
33
137
2.49
5.39
1.7
1.5
0.0
0.1
iu/ml
—
9
29
122
807
1.65
5.32
4.8
3.4
61.0
323.2
ng/l
2.24
82
579
144
994
1.60
5.28
4.4
3.8
1.0
1.0
kg/l
1.18
28
135
10
21
4.83
4.54
3.0
4.4
885.6
649.2
u/ml
—
10
21
100
654
1.64
4.53
3.3
2.8
0.8
0.8
mmol/l
1.83
94
620
70
421
1.75
4.31
2.3
2.1
29.0
32.9
u/l
0.65
57
349
540
5062
1.99
4.29
12.1
9.2
24.8
24.4
u/l
0.31
524
4893
284
2334
1.43
4.25
4.1
3.4
0.0
0.0
estimate
0.00
47
429
52
290
1.87
4.10
1.4
1.5
—
—
—
0
0
34
163
2.15
4.06
1.5
1.6
—
—
—
0
0
287
2376
1.41
4.06
4.3
3.5
0.0
0.0
estimate
0.80
47
418
54
306
1.84
4.05
7.1
5.7
10.9
8.4
mmol/l
1.56
54
292
485
4438
1.57
3.92
14.7
10.9
83.3
83.9
ml/min/173m2
0.25
410
3569
496
4563
1.61
3.91
4.8
4.1
5.9
5.8
mmol/l
0.50
452
4192
99
674
1.57
3.78
2.0
1.8
—
—
—
0
0
282
2347
1.39
3.77
5.8
4.7
0.0
0.0
estimate
0.50
47
426
13
40
3.30
3.64
1.2
1.1
—
—
—
0
0
13
40
3.30
3.64
1.2
1.1
—
—
—
0
0
362
3152
1.40
3.64
3.4
2.9
43.3
42.0
u/l
0.14
343
2962
44
243
1.88
3.59
1.5
1.7
—
—
—
0
0
32
158
2.09
3.57
2.1
1.9
1.8
1.5
g/l
0.64
26
138
28
131
2.20
3.57
1.3
1.2
5.3
3.3
u/ml
—
6
16
13
41
3.22
3.51
1.2
1.1
—
—
—
0
0
13
41
3.22
3.51
1.2
1.1
—
—
—
0
0
13
41
3.22
3.51
1.2
1.1
—
—
—
0
0
68
431
1.65
3.48
2.7
4.0
240.4
238.1
u/l
0.06
63
406
28
133
2.16
3.45
1.3
1.2
9.8
6.7
u/ml
—
6
26
156
1189
1.43
3.41
3.7
3.9
11.6
10.2
mg/mmol
0.11
102
744
22
95
2.37
3.38
1.4
1.2
—
—
—
0
0
130
966
1.45
3.25
1.9
1.5
—
—
—
0
0
466
4275
1.46
3.25
6.1
5.0
40.0
38.9
mmol/mol
1.35
421
4001
15
55
2.77
3.17
1.2
1.2
—
—
—
0
0
120
883
1.45
3.15
1.7
1.6
422.5
42530714.5
pmol/l
1.58
94
743
154
1188
1.40
3.12
3.2
2.8
0.2
0.5
e6/l
2.21
118
864
483
4474
1.48
3.08
19.5
12.8
39.1
39.4
%
0.37
351
3375
38
211
1.86
3.08
3.8
3.7
3.5
1.8
mmol/l
1.06
31
155
15
56
2.72
3.08
1.2
1.2
—
—
—
0
0
15
56
2.72
3.08
1.2
1.2
—
—
—
0
0
376
3346
1.35
2.99
3.7
3.3
—
—
—
0
0
15
57
2.67
2.98
1.1
1.2
—
—
—
0
0
15
57
2.67
2.98
1.2
1.2
—
—
—
0
0
31
163
1.95
2.96
2.4
1.8
—
—
—
0
0
130
982
1.42
2.96
1.7
1.5
17.5
22.4
nmol/l
3.68
103
832
17
71
2.44
2.82
1.8
1.7
—
—
—
0
0
501
4697
1.49
2.78
4.7
4.0
4.7
4.8
mmol/l
1.08
461
4394
499
4676
1.49
2.76
4.7
3.9
1.5
1.6
mmol/l
2.30
453
4355
157
1239
1.37
2.74
2.9
3.0
6.9
7.2
mmol/l
0.28
132
1060
218
1810
1.33
2.71
4.3
3.6
—
—
—
0
0
28
148
1.94
2.65
1.6
1.9
0.9
2.9
ug/l
0.51
23
136
28
149
1.92
2.60
2.3
1.7
—
—
—
0
0
139
1087
1.37
2.55
2.8
2.0
—
—
—
0
0
6
11
5.50
2.55
1.2
1.1
—
—
—
0
0
6
11
5.50
2.55
1.2
1.1
101.2
101.7
%
—
6
11
90
654
1.45
2.52
3.0
2.6
4.4
3.3
e6/l
0.30
47
322
14
57
2.49
2.46
1.1
1.2
—
—
—
0
0
50
322
1.61
2.45
2.0
2.5
66.1
67.7
g/l
0.76
43
297
68
472
1.50
2.40
1.7
1.8
—
—
—
0
0
36
214
1.73
2.38
1.7
1.8
3.1
2.9
mg/l
0.09
25
152
28
157
1.82
2.25
1.3
1.6
9.9
10.6
g/l
0.42
23
140
254
2196
1.28
2.23
4.4
3.7
—
—
—
0
0
66
463
1.48
2.22
5.6
5.9
104.0
104.4
mmol/l
0.28
66
455
48
315
1.57
2.19
2.1
2.2
3.4
5.6
ug/l
1.83
38
278
29
167
1.78
2.15
1.2
1.6
—
—
—
0
0
29
167
1.78
2.15
1.2
1.6
3.6
3.8
g/l
0.37
20
126
29
167
1.78
2.15
1.3
1.6
7.3
7.5
g/l
0.19
21
135
93
701
1.39
2.13
3.0
2.4
1.1
1.2
e6/l
0.28
51
369
102
784
1.37
2.08
2.2
2.7
2.4
2.5
mmol/l
1.78
90
693
24
132
1.85
2.07
1.7
1.2
—
—
—
0
0
503
4775
1.41
2.06
5.2
4.4
2.8
2.8
mmol/l
1.12
460
4439
477
4491
1.35
2.05
4.2
3.6
1.3
1.2
mmol/l
1.27
435
4161
24
135
1.81
1.94
1.3
1.6
39.9
38.0
g/l
0.67
19
120
9
33
2.75
1.94
1.1
1.1
—
—
—
0
0
19
99
1.95
1.92
1.2
1.1
1.0
1.8
u/ml
—
7
33
66
479
1.43
1.89
1.8
1.8
—
—
—
0
0
25
144
1.77
1.88
1.3
1.8
0.0
1.0
g/l
1.82
20
131
69
508
1.41
1.83
6.8
6.2
—
—
—
0
0
68
501
1.40
1.80
2.7
2.6
5.7
6.4
umol/l
0.28
55
422
70
519
1.40
1.79
4.5
4.0
33.3
32.6
%
0.18
51
349
8
30
2.69
1.73
1.1
1.9
22.5
21.5
nmol/l
—
8
30
16
82
1.98
1.71
1.1
1.3
—
—
—
0
0
26
157
1.69
1.68
1.3
1.6
3.2
3.1
g/l
0.15
20
130
5
14
3.59
1.62
1.2
1.3
88.7
213.1
iu/ml
—
5
14
50
356
1.44
1.61
4.7
3.1
6.0
5.8
kpa
0.85
50
346
6
20
3.02
1.58
1.7
1.2
—
—
—
0
0
6
20
3.02
1.58
1.0
1.0
—
—
—
0
0
6
20
3.02
1.58
1.7
1.2
—
—
—
0
0
49
352
1.43
1.51
7.4
7.4
120.3
119.7
g/l
0.09
49
341
147
1241
1.25
1.50
4.7
3.7
0.0
0.0
estimate
0.80
46
421
18
102
1.79
1.46
1.7
1.3
—
—
—
0
0
9
38
2.39
1.46
2.0
2.0
—
—
—
0
0
13
67
1.96
1.39
1.5
1.1
—
—
—
0
0
6
23
2.62
1.37
1.2
1.1
—
—
—
0
0
58
439
1.36
1.34
6.7
6.7
1.9
1.3
mmol/l
0.84
49
344
18
105
1.74
1.34
7.4
4.7
3.7
3.9
mmol/l
0.62
18
99
33
229
1.47
1.25
2.5
2.0
1516.1
2842.1
u/l
0.54
17
95
5
19
2.65
1.22
1.0
1.1
—
—
—
0
0
8
37
2.18
1.22
1.3
1.3
—
—
—
0
0
15
86
1.76
1.20
1.7
1.2
5.0
3.1
u/ml
—
7
32
27
182
1.51
1.18
2.5
2.1
0.7
0.7
%
0.11
27
175
14
79
1.79
1.18
1.3
1.4
—
—
—
0
0
14
79
1.79
1.18
1.3
1.4
—
—
—
0
0
16
96
1.69
1.11
4.6
3.6
21.3
30.0
mg/l
—
8
59
7
31
2.27
1.10
1.4
1.1
—
—
—
0
0
143
1242
1.20
1.10
1.8
1.6
1.4
1.4
mmol/l
0.43
116
1062
12
66
1.84
1.09
1.2
1.2
—
—
—
0
0
35
254
1.40
1.07
1.3
1.5
—
—
—
0
0
33
240
1.40
1.01
3.5
2.7
132.3
127.5
g/l
0.56
33
234
9
48
1.89
1.01
3.8
3.7
—
—
—
0
0
45
346
1.33
0.98
3.3
3.2
1.2
1.2
mmol/l
1.58
36
308
15
92
1.65
0.98
1.7
1.7
—
—
—
0
0
19
124
1.55
0.98
1.4
3.1
—
2.6
—
0
12
0
30
0.00
0.97
0.0
1.6
—
—
—
0
0
9
50
1.81
0.97
1.1
1.1
—
—
—
0
0
6
27
2.23
0.93
2.3
2.1
—
—
—
0
0
6
28
2.15
0.91
2.3
2.1
13.3
11.0
%
—
6
16
14
86
1.64
0.91
1.6
1.2
1.4
4.4
u/ml
—
5
26
45
351
1.31
0.90
2.1
2.4
68.8
71.0
ml/min/173m2
0.11
19
132
22
153
1.46
0.87
1.2
1.1
—
—
—
0
0
8
44
1.83
0.86
1.3
1.2
—
—
—
0
0
17
112
1.53
0.85
1.4
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
69
584
1.21
0.72
5.4
4.7
6.4
2.7
ug/l
0.43
63
522
21
151
1.41
0.72
1.2
1.1
—
—
—
0
0
19
135
1.42
0.70
1.3
1.3
—
—
—
0
0
12
77
1.57
0.69
1.5
1.2
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
48
394
1.24
0.68
2.0
1.8
—
—
—
0
0
14
94
1.50
0.67
2.3
2.2
137.5
130.5
g/l
—
8
66
63
537
1.19
0.63
1.5
1.7
1.4
1.4
%
0.05
55
478
17
121
1.42
0.63
1.4
1.5
546.4
480.4
mg/l
0.25
17
114
13
88
1.49
0.61
2.3
1.7
5926.4
13501.6
e6/l
—
8
62
8
51
1.58
0.60
1.1
1.1
—
—
—
0
0
10
150
0.66
0.59
1.4
1.5
—
—
—
0
0
25
195
1.29
0.55
1.3
1.3
145.4
248.6
miu/ml
0.86
14
101
52
442
1.19
0.55
3.5
3.0
—
—
—
0
0
12
82
1.47
0.54
1.7
1.6
—
—
—
0
0
39
324
1.22
0.52
1.2
1.4
31.3
30.5
iu/l
0.04
30
281
13
92
1.42
0.51
1.5
1.7
—
—
—
0
0
22
171
1.30
0.50
1.6
1.6
—
—
—
0
0
52
448
1.18
0.49
2.2
3.9
2.6
18.7
ug/l
0.99
37
357
17
222
0.76
0.48
1.2
1.5
—
—
—
0
0
34
283
1.21
0.46
1.0
1.0
—
—
—
0
0
11
77
1.44
0.46
2.9
1.5
11.5
2.7
ug/l
0.39
11
68
14
104
1.35
0.43
1.2
1.6
—
—
—
0
0
5
32
1.57
0.42
1.2
1.0
—
—
—
0
0
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
5
33
1.52
0.41
2.2
1.5
1.1
1.0
g/l
—
5
33
5
34
1.47
0.40
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.8
—
—
—
0
0
5
36
1.39
0.38
1.2
1.3
—
—
—
0
0
28
234
1.21
0.38
1.4
1.5
—
—
—
0
0
53
473
1.13
0.34
1.7
1.7
—
—
—
0
0
16
128
1.26
0.32
5.3
2.5
3.7
3.7
g/l
0.04
16
122
8
63
1.27
0.28
1.9
1.4
—
—
—
0
0
29
253
1.15
0.26
1.5
1.5
—
—
—
0
0
69
637
1.09
0.26
2.1
2.1
—
—
—
0
0
10
77
1.30
0.26
1.2
1.1
—
—
—
0
0
9
74
1.22
0.25
1.6
1.2
—
—
—
0
0
9
74
1.22
0.25
1.4
1.1
—
—
—
0
0
16
133
1.21
0.24
4.3
2.4
182.4
174.9
%
0.14
16
128
51
466
1.10
0.24
4.5
4.1
18.1
21.2
%
0.95
24
215
5
39
1.28
0.23
1.0
1.7
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
1.2
—
0
10
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
8.2
—
0
8
6
50
1.20
0.19
1.0
1.6
—
—
—
0
0
11
133
0.82
0.19
2.1
1.6
—
—
—
0
0
10
81
1.24
0.19
1.4
1.4
—
—
—
0
0
12
100
1.20
0.18
1.3
1.6
—
—
—
0
0
7
61
1.15
0.17
1.1
1.3
16.3
15.1
u/l
—
7
55
13
110
1.19
0.17
2.1
1.5
—
—
—
0
0
18
158
1.14
0.16
7.1
5.0
1.9
1.5
%
0.55
18
147
15
131
1.15
0.14
1.1
1.1
—
—
—
0
0
61
580
1.06
0.13
1.9
1.9
—
—
—
0
0
34
320
1.07
0.10
1.5
1.5
—
—
—
0
0
5
46
1.09
0.09
1.6
1.4
—
11.8
—
0
8
36
340
1.06
0.09
3.3
2.8
0.7
0.7
ug/l
0.46
26
221
11
123
0.89
0.08
2.5
3.5
1.4
1.5
mg/l
0.36
11
113
32
304
1.06
0.07
1.8
1.7
—
—
—
0
0
20
188
1.07
0.05
1.4
1.5
—
—
—
0
0
113
1111
1.02
0.05
1.5
1.4
—
—
—
0
0
20
189
1.06
0.04
3.5
1.8
—
—
—
0
0
12
111
1.08
0.04
1.2
1.9
449.8
287.1
e6/l
0.15
12
85
12
111
1.08
0.04
1.2
1.8
15.6
7.7
e6/l
0.29
12
79
17
178
0.95
0.02
1.3
1.4
—
—
—
0
0
17
178
0.95
0.02
1.3
1.4
—
—
—
0
0
28
288
0.97
0.02
1.6
1.4
—
—
—
0
0
17
177
0.96
0.01
1.3
1.4
—
—
—
0
0
17
177
0.96
0.01
1.3
1.4
—
—
—
0
0
12
116
1.04
0.00
1.7
1.5
—
—
—
0
0
15
146
1.03
0.00
4.5
2.1
96.2
95.1
%
0.09
15
138
7
73
0.96
0.00
2.9
1.9
13.1
13.2
%
—
7
73
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.2
1.1
—
—
—
0
0
5
54
0.93
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
6
62
0.97
0.00
1.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
57
0.88
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
7
72
0.97
0.00
1.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
5
51
0.98
0.00
2.4
1.3
0.8
0.5
nmol/l
—
5
45
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.07 [0.88, 1.3] | 0.502 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 1872 females with E4_THYROIDITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITNAS | 1.031 [0.79, 1.35] | 0.827 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 435 males with E4_THYROIDITNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.199% |
| 5 | 0.55% | 1.133% |
| 10 | 1.31% | 2.965% |
| 15 | 2.674% | 5.73% |
| 20 | 4.741% | 9.773% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITNAS – Thyroiditis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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