retinal artery occlusion: Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
817 |
4. Check minimum number of eventsNone |
817 |
5. Include endpointsNone |
817 |
6. Filter based on genotype QC (FinnGen only) |
817 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H34
- Name in latin
- Aliae occlusiones arteriales retinae
Similar endpoints
↥List of similar endpoints to
Other retinal artery occlusion
based on the number of shared cases.
Similar with more cases:
- Retinal vascular disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6560 | 2771 | 3720 |
| Only index persons | 5215 | 2234 | 2981 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.08 | 0.10 |
| Only index persons | 0.10 | 0.08 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 68.13 | 69.45 | 67.22 |
| Only index persons | 68.45 | 69.76 | 67.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 817 | 310 | 507 |
| Unadjusted period prevalence (%) | 0.18 | 0.11 | 0.22 |
| Median age at first event (years) | 67.87 | 66.94 | 68.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 734
- Matched controls
- 7340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H34.2
ICD-10 Finland
Other retinal artery occlusions
4503599627370496.0
323.0
672
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
1574.9
138.1
130
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
97.1
91
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.0
80.8
156
161
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.9
71.8
179
286
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
136.9
70.3
74
6
CKC12
NOMESCO Finland
Photocoagulation of retina
177.9
63.1
65
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.9
62.3
170
305
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
12.6
54.6
101
92
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
7.5
53.9
137
219
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.3
51.3
100
101
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
50.5
201
552
AA1AD
NOMESCO Finland
CT of head and brain
3.5
49.9
308
1245
XCK00
NOMESCO Finland
Perimetry
6.7
48.3
133
236
B01AC04
ATC
clopidogrel; oral
3.7
47.7
256
917
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
8.9
47.4
106
137
37703
ICD-8 Finland
Other diseases of retina and optic nerve, Thrombosis venae centralis retinae
+∞
46.3
44
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
5.4
45.5
151
337
H43.1
ICD-10 Finland
Vitreous haemorrhage
31.9
44.7
59
20
C10AA05
ATC
atorvastatin; oral
3.0
44.4
420
2250
H53.4
ICD-10 Finland
Visual field defects
14.2
41.0
71
55
XCD20
NOMESCO Finland
Photoangiography of eye
79.9
40.4
45
6
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
105.6
37.1
40
*
H53.1
ICD-10 Finland
Subjective visual disturbances
6.4
34.8
96
168
G45.3
ICD-10 Finland
Amaurosis fugax
11.2
31.8
61
59
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
9.7
29.0
60
67
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
78.2
27.0
30
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.5
25.4
96
239
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
22.7
377
2389
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
18.7
22.4
34
19
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.1
22.3
140
524
H53.9
ICD-10 Finland
Visual disturbance, unspecified
7.9
21.2
49
66
CKC10
NOMESCO Finland
Local photocoagulation of retina
61.9
21.0
24
*
3623B
ICD-9 Finland
Other retinal disorders, Retinal vascular occlusion[OCCLUSIO RAMI ARTERIAE CENTRALIS RETINAE]
+∞
20.9
20
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.2
20.7
264
1468
H3601, E113
ICD-10 Finland
NA
+∞
19.9
19
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
56.6
19.0
22
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
35.4
19.0
24
7
WX140
NOMESCO Finland
Parabulbar anesthesy
7.9
18.9
43
57
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
18.8
139
574
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
18.8
18
*
H3600, E113
ICD-10 Finland
NA
+∞
18.8
18
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
18.0
502
3778
C08CA01
ATC
amlodipine; oral
2.0
17.8
326
2078
H34.0
ICD-10 Finland
Transient retinal artery occlusion
+∞
17.8
17
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
184.2
17.6
18
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
184.2
17.6
18
*
PA6AD
NOMESCO Finland
CT of neck arteries
12.4
17.4
31
26
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
17.3
122
490
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
11.9
17.2
31
27
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
17.9
17.0
26
15
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
16.9
251
1463
H53.8
ICD-10 Finland
Other visual disturbances
15.5
16.8
27
18
C10AA01
ATC
simvastatin; oral
1.9
16.2
409
2905
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.1
16.0
228
1299
H34.9
ICD-10 Finland
Retinal vascular occlusion, unspecified
+∞
15.7
15
*
C01DA14
ATC
isosorbide mononitrate; oral
2.1
15.3
196
1065
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
14.9
108
438
CKD40
NOMESCO Finland
Endophotocoagulation of retina
57.9
14.8
17
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.9
14.8
97
371
CS494
NOMESCO Finland
Other visual field testing
8.3
14.7
32
40
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
14.5
210
1194
CKC15
NOMESCO Finland
Panretinal photocoagulation
152.9
14.5
15
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
14.3
246
1498
H25.1
ICD-10 Finland
Senile nuclear cataract
2.0
14.3
246
1499
C07AB07
ATC
bisoprolol; oral
1.8
14.1
410
2997
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.8
13.9
39
70
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
13.8
155
790
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.6
13.4
106
453
114
Kela drug reimbursment
Glaucoma
2.7
13.2
98
403
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
7.1
13.0
31
45
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
12.8
191
1094
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
12.5
12
*
A10BA02
ATC
metformin; oral
1.9
12.5
251
1601
C03CA01
ATC
furosemide; systemic
1.8
12.4
292
1964
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
12.2
233
1460
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
12.0
169
943
T90
ICPC
Diabetes non-insulin dependent
1.9
12.0
202
1207
N02BE01
ATC
paracetamol; systemic, rectal
2.0
12.0
602
5134
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.8
11.9
274
1824
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.6
11.8
93
394
S01ED51
ATC
timolol, combinations; ophthalmic
2.8
11.8
77
293
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
9.1
11.8
24
27
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.1
11.8
64
216
F05
ICPC
Visual disturbance other
5.5
11.8
34
64
C10AX09
ATC
ezetimibe; oral
2.5
11.6
98
432
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.8
11.6
271
1807
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
11.4
211
1299
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
15.3
11.3
18
12
ZXA10
NOMESCO Finland
Bilateral
2.1
11.3
149
808
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
13.0
11.2
19
15
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.1
11.1
63
218
A02BC02
ATC
pantoprazole; systemic
1.7
11.1
457
3597
N02AX02
ATC
tramadol; systemic, rectal
1.7
10.8
319
2274
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.7
10.8
74
290
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.8
10.7
71
274
XCH00
NOMESCO Finland
Eye pressure measurement
3.9
10.7
43
115
H54.4
ICD-10 Finland
Blindness, monocular
60.9
10.6
12
*
PA7BD
NOMESCO Finland
CT angiography of neck and brain
5.8
10.5
29
52
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
10.4
10
*
H3603, E113
ICD-10 Finland
NA
+∞
10.4
10
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
10.4
10
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.9
10.4
33
70
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.1
10.4
127
665
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.3
10.3
97
451
280
Kela drug reimbursment
Clopidogrel
5.3
10.2
30
58
C09CA01
ATC
losartan; oral
1.8
10.2
201
1257
S01EC01
ATC
acetazolamide; systemic
5.3
10.1
30
59
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
10.0
211
1347
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.9
10.0
175
1053
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
7.8
10.0
22
29
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
9.8
282
1979
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
9.8
155
896
A10AE04
ATC
insulin glargine; parenteral
2.5
9.7
80
348
CKC20
NOMESCO Finland
Cryopexy of undetached retina
55.7
9.7
11
*
205
Kela drug reimbursment
Chronic hypertension
1.7
9.6
265
1834
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.7
9.6
64
248
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
9.5
152
882
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
9.4
9
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.3
9.4
47
151
ZXA05
NOMESCO Finland
Left side
1.8
9.2
200
1284
B01AA03
ATC
warfarin; systemic
1.7
9.1
209
1364
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.2
9.1
93
449
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
9.0
61
239
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
3.0
8.8
50
173
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.5
8.8
30
69
I20.09
ICD-10 Finland
Unstable angina
2.5
8.8
69
293
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.9
8.8
132
746
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
8.8
66
274
C09AA05
ATC
ramipril; oral
1.7
8.7
218
1458
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.6
196
1274
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
8.6
206
1364
J01AA02
ATC
doxycycline; systemic
1.6
8.5
531
4505
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
91.0
8.4
9
*
H35.37
ICD-10 Finland
Macular holes
+∞
8.3
8
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
14.7
8.2
13
9
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.6
8.1
59
241
ZXA00
NOMESCO Finland
Right side
1.7
8.1
206
1381
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.4
8.1
65
280
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
33.7
8.1
10
*
H33.5
ICD-10 Finland
Other retinal detachments
17.4
8.1
12
7
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
3.9
8.0
31
81
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
6.7
7.9
19
29
C07AB02
ATC
metoprolol; systemic
1.7
7.9
193
1276
M04AA01
ATC
allopurinol; systemic
1.9
7.7
126
736
C10AA04
ATC
fluvastatin; oral
2.1
7.7
88
447
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
7.7
145
888
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
7.6
37
117
J01CA04
ATC
amoxicillin; systemic
1.6
7.5
509
4325
AN1
HP
Coronary angiography
1.9
7.5
121
702
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.6
7.5
53
214
81
HP
Angiography of the heart and coronary arteries
2.1
7.4
83
419
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
7.4
24
53
H40.0
ICD-10 Finland
Glaucoma suspect
2.4
7.4
60
258
FXZ00
NOMESCO Finland
Off-pump cardiac operation
7.8
7.4
16
21
F29
ICPC
Eye symptom/complaint other
2.4
7.4
60
260
11
HP
Coronary artery bypass surgery
3.1
7.4
38
126
H3600, E103
ICD-10 Finland
NA
+∞
7.3
7
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
7.3
7
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
7.3
7
*
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
+∞
7.3
7
*
H3601, E103
ICD-10 Finland
NA
+∞
7.3
7
*
A10AE05
ATC
insulin detemir; parenteral
2.9
7.3
43
156
H04AA01
ATC
glucagon; nasal, parenteral
7.4
7.2
16
22
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
30.3
7.2
9
*
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.2
7.1
74
362
WX872
NOMESCO Finland
Intensive care
2.7
7.1
47
183
B03XA02
ATC
darbepoetin alfa; parenteral
4.8
7.1
22
47
C08CA05
ATC
nifedipine; systemic
2.2
7.0
68
321
ZX120
NOMESCO Finland
Intravenous
2.1
7.0
77
385
C10AA07
ATC
rosuvastatin; oral
1.7
6.9
177
1182
WX002
NOMESCO Finland
Sedation and analgesia
1.7
6.8
141
885
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.8
293
2227
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
6.7
93
510
N03AX16
ATC
pregabalin; oral
1.7
6.7
153
989
S01EE01
ATC
latanoprost; ophthalmic
2.3
6.7
58
259
R4110
NOMESCO Finland
Physiotherapy
1.6
6.6
186
1270
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
12.4
6.6
11
9
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.9
6.5
90
493
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.3
6.5
55
245
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.5
6.5
49
206
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
70.4
6.4
7
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
14.5
6.4
10
7
H36.00
ICD-10 Finland
Diabetic background retinopathy
14.5
6.4
10
7
J01FF01
ATC
clindamycin; systemic
1.6
6.4
176
1198
N18.0
ICD-10 Finland
End-stage renal disease
6.0
6.3
16
27
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.9
6.3
24
63
H26.4
ICD-10 Finland
After-cataract
2.1
6.3
70
352
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
18.2
6.3
9
5
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
3.5
6.3
27
79
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
6.3
95
539
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
+∞
6.3
6
*
H3603, E103
ICD-10 Finland
NA
+∞
6.3
6
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
7.1
6.2
14
20
A11CC03
ATC
alfacalcidol; systemic
4.0
6.2
23
59
B01AC07
ATC
dipyridamole; systemic
2.3
6.2
56
258
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.2
151
992
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.3
6.2
21
50
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.6
6.2
43
171
S01ED01
ATC
timolol; ophthalmic
2.8
6.1
36
131
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.7
6.1
12
14
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.6
6.0
40
157
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
2.9
6.0
35
126
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.0
54
247
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
375
2079
2.49
34.96
2.8
2.1
222.4
259.3
u/l
0.19
359
1949
304
1803
2.09
21.51
2.7
2.2
3.1
3.1
mg/l
0.02
259
1518
541
3977
2.07
20.78
6.7
4.9
7.0
6.8
mmol/l
1.79
516
3743
36
62
6.03
20.24
1.3
1.2
2.8
5.7
u/ml
0.39
13
25
36
64
5.84
19.60
1.3
1.3
2.9
7.8
u/ml
0.92
21
33
357
2327
1.95
18.72
3.7
3.2
2556.4
1777.3
ng/l
1.65
311
2008
96
372
2.79
17.65
1.7
1.9
1.6
1.6
g/l
0.16
83
329
191
1021
2.14
17.20
3.3
2.5
2.2
2.3
g/l
0.55
184
939
184
975
2.15
16.93
3.4
2.6
18.3
22.2
%
3.93
161
822
317
2047
1.90
16.60
4.1
3.0
6.6
7.5
mmol/l
3.82
269
1682
139
669
2.30
16.14
8.3
6.3
12.8
10.8
mmol/l
2.07
130
630
32
63
5.25
15.63
1.1
1.1
—
—
—
0
0
196
1104
2.02
15.14
3.3
2.5
9.8
12.1
umol/l
6.02
187
1018
476
3584
1.79
14.37
9.2
8.6
4.6
4.3
e9/l
2.07
401
3132
318
2137
1.80
14.09
4.9
3.8
16.5
8.1
mg/mmol
1.96
219
1384
361
2532
1.76
13.72
3.7
2.8
144.8
149.6
ug/l
0.17
335
2278
172
963
2.00
13.35
7.5
5.2
1.1
1.0
mmol/l
1.04
162
881
134
690
2.13
13.03
5.0
3.5
1.8
2.1
mmol/l
0.47
117
554
127
641
2.16
13.00
7.4
7.3
1.4
1.5
mmol/l
0.19
121
615
380
2735
1.73
12.95
5.3
4.0
72.8
57.4
ng/l
0.17
299
2074
81
340
2.53
12.65
6.7
3.7
24.1
24.2
mmol/l
0.14
76
312
161
898
1.99
12.57
7.1
7.4
0.8
1.2
mmol/l
0.45
119
687
250
1609
1.80
12.52
3.1
2.4
—
—
—
0
0
178
1030
1.93
12.48
37.5
28.2
1.4
1.4
inr
0.03
22
134
565
4576
1.76
12.23
5.1
4.0
17.7
14.1
mm/h
4.17
532
4171
154
856
1.98
12.11
2.8
3.9
242.7
255.7
u/l
0.36
137
799
159
894
1.97
12.10
7.3
7.4
5.0
5.1
kpa
1.13
146
848
159
895
1.96
12.06
7.3
7.4
11.2
11.8
kpa
0.89
146
852
220
1379
1.81
11.94
5.3
4.2
567.9
335.5
ng/l
0.45
186
1181
260
1717
1.75
11.80
3.4
2.9
7239.5
9269.5
umol/l
0.23
219
1448
133
718
2.02
11.31
7.9
8.3
115.5
120.1
g/l
1.91
127
689
397
2970
1.65
11.14
5.9
4.9
33.9
34.7
g/l
1.55
356
2749
415
3153
1.64
10.86
8.4
6.1
1.2
1.2
mmol/l
0.72
381
2846
17
26
6.66
10.67
1.1
1.2
—
—
—
0
0
94
456
2.20
10.56
8.5
9.6
94.1
93.7
%
0.44
94
449
440
3436
1.61
9.97
9.5
7.0
1.2
1.2
mmol/l
0.45
373
2889
528
4315
1.63
9.87
6.1
4.9
631.3
2692.5
e6/l
—
6
74
224
1481
1.71
9.84
1.9
1.8
1112.9
1153.8
nmol/l
0.26
168
1113
178
1103
1.78
9.83
2.8
3.2
0.8
0.8
mmol/l
0.52
168
1024
340
2505
1.61
9.75
5.0
3.4
—
—
—
0
0
381
2885
1.60
9.74
2.4
2.1
94.5
93.2
pmol/l
0.20
222
1517
656
5687
1.78
9.67
8.1
6.2
42.7
40.5
mmol/mol
6.26
610
5177
688
6066
1.85
9.36
26.2
16.9
27.7
27.3
mg/l
0.11
600
4963
99
523
2.02
8.88
2.1
1.7
—
—
—
0
0
117
662
1.90
8.59
3.4
2.6
4.7
7.2
ug/l
1.87
100
565
102
551
1.97
8.59
5.8
3.8
128.6
98.0
ng/l
1.30
87
477
82
412
2.10
8.42
8.7
9.9
24.3
24.5
mmol/l
0.25
72
381
112
631
1.90
8.33
2.4
2.9
65.9
66.0
g/l
0.06
99
573
642
5608
1.68
8.30
5.0
4.1
1.3
1.3
mmol/l
1.23
586
5001
429
3441
1.52
7.88
6.0
6.2
12.0
12.1
umol/l
0.07
408
3271
194
1305
1.64
7.75
1.6
1.7
1.2
1.3
mg/l
0.41
148
1027
575
4923
1.57
7.73
8.7
7.6
82.4
80.0
u/l
0.49
538
4601
621
5425
1.60
7.52
5.1
4.6
2.1
2.0
mu/l
0.23
563
4846
55
247
2.32
7.44
1.7
2.0
41.4
38.3
u/l
0.47
44
220
380
3002
1.50
7.31
5.8
4.2
—
—
—
0
0
180
1206
1.63
7.26
4.0
3.0
1.3
1.1
e6/l
0.26
108
734
173
1148
1.64
7.25
4.2
3.2
1.6
2.0
e6/l
0.34
104
679
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
61
290
2.19
7.21
3.2
2.5
0.4
0.4
u/ml
0.05
34
164
703
6367
1.75
7.07
31.7
20.2
139.3
139.6
mmol/l
2.53
684
6186
264
1953
1.52
6.87
4.7
3.4
0.4
0.5
e6/l
0.27
205
1514
703
6381
1.73
6.83
32.1
20.4
4.0
4.0
mmol/l
0.50
682
6199
381
3041
1.47
6.81
4.8
3.9
0.0
0.0
estimate
0.50
65
557
41
168
2.52
6.78
1.9
1.5
0.1
34.4
iu/ml
0.49
12
35
668
5998
1.62
6.60
6.5
5.2
2.3
2.6
mmol/l
18.39
616
5403
377
3020
1.46
6.52
4.8
3.9
0.0
0.0
estimate
0.00
68
566
445
3689
1.45
6.37
3.5
3.2
58.7
53.9
u/l
0.37
413
3383
374
3003
1.45
6.33
6.3
5.3
0.0
0.0
estimate
0.00
70
567
653
5849
1.58
6.33
5.7
4.6
4.1
4.5
mmol/l
15.88
604
5313
180
1245
1.57
6.28
2.1
1.9
—
—
—
0
0
318
2482
1.46
6.21
2.4
2.2
79.3
78.8
nmol/l
0.13
284
2168
647
5799
1.56
6.08
5.6
4.6
1.3
1.4
mmol/l
7.07
593
5219
16
40
4.06
5.92
1.1
1.1
—
—
—
0
0
655
5908
1.55
5.76
5.6
4.9
6.3
6.1
mmol/l
4.41
591
5283
131
871
1.60
5.36
2.2
1.8
—
—
—
0
0
291
2286
1.42
5.30
3.3
3.4
2.4
2.3
mmol/l
0.29
250
1961
39
176
2.28
5.27
1.3
1.3
1.2
1.2
g/l
0.01
34
167
59
313
1.95
5.26
1.3
1.4
—
54.3
—
0
19
94
579
1.70
5.18
2.9
2.4
35.6
32.7
u/l
0.31
78
492
74
428
1.80
5.07
1.5
1.5
—
—
—
0
0
129
868
1.58
5.01
2.2
1.8
—
—
—
0
0
711
6593
1.60
4.91
38.1
24.8
130.2
133.4
g/l
5.48
695
6457
46
229
2.07
4.90
1.3
1.3
—
—
—
0
0
691
6376
1.54
4.77
14.1
10.8
24.3
25.3
u/l
0.91
665
6096
626
5671
1.44
4.67
24.7
16.0
70.0
74.2
ml/min/173m2
4.79
532
4714
548
4851
1.39
4.66
32.1
20.7
14.1
13.9
%
3.44
535
4739
54
296
1.88
4.41
2.0
2.8
4.1
3.7
g/l
0.72
36
215
183
1360
1.45
4.40
3.4
3.2
2.5
2.5
mmol/l
0.21
153
1186
54
297
1.88
4.36
2.0
2.8
7.3
7.5
g/l
0.23
37
222
54
297
1.88
4.36
2.0
2.8
—
—
—
0
0
255
2021
1.38
4.23
2.9
2.5
63.5
57.1
u/l
0.58
238
1850
31
141
2.25
4.16
1.5
1.6
—
—
—
0
0
228
1778
1.39
4.16
1.8
1.6
19.2
20.4
nmol/l
0.52
194
1509
50
273
1.89
4.14
2.1
2.8
3.1
3.2
g/l
0.25
36
219
197
1504
1.41
4.06
3.9
2.6
3.6
4.6
e6/l
1.49
177
1326
27
117
2.35
4.05
1.1
1.2
56.5
35.3
u/l
0.35
22
100
37
184
2.06
3.99
1.1
1.2
—
—
—
0
0
106
719
1.54
3.97
2.8
2.6
7.1
9.5
umol/l
0.81
92
630
498
4396
1.34
3.97
4.0
3.7
15.0
15.1
pmol/l
0.15
447
3909
350
2936
1.34
3.96
2.4
2.5
—
—
—
0
0
77
490
1.63
3.78
6.5
6.4
24.1
24.2
mmol/l
0.13
72
458
36
183
2.01
3.68
1.1
1.2
—
—
—
0
0
43
235
1.88
3.58
1.3
1.3
—
—
—
0
0
240
1929
1.35
3.55
3.0
3.2
30.4
34.7
u/l
1.28
227
1832
76
491
1.60
3.52
3.2
3.0
52.2
59.8
ml/min/173m2
1.03
32
209
48
279
1.77
3.30
1.4
2.8
9.6
10.6
g/l
1.15
39
241
32
168
1.94
3.03
1.7
1.7
15068.6
17382.8
e6/l
0.18
26
122
195
1556
1.33
2.97
1.7
1.6
1.4
1.3
mmol/l
0.88
165
1305
172
1348
1.35
2.96
5.2
4.3
1.0
1.0
kg/l
0.54
21
217
20
88
2.30
2.95
1.2
1.5
—
—
—
0
0
113
828
1.42
2.91
10.7
7.8
—
—
—
0
0
36
200
1.84
2.90
1.4
1.4
—
—
—
0
0
572
5262
1.29
2.81
29.7
18.6
37.8
39.0
%
1.84
374
3355
36
203
1.81
2.77
2.0
1.6
—
—
—
0
0
78
538
1.50
2.75
1.8
2.0
423.6
372.9
nmol/l
0.53
71
485
45
273
1.69
2.71
3.4
3.6
1.4
1.4
mmol/l
0.01
45
267
6
10
6.03
2.70
1.0
1.0
—
—
—
0
0
6
10
6.03
2.70
16.2
12.0
5.1
7.1
mmol/l
—
6
10
203
1652
1.30
2.67
5.7
4.1
0.0
0.0
estimate
0.50
66
539
17
73
2.36
2.66
1.3
1.1
1.6
1.5
g/l
0.07
17
63
10
32
3.15
2.65
1.2
1.0
—
—
—
0
0
7
15
4.70
2.60
1.4
1.9
—
—
—
0
0
42
254
1.69
2.57
1.5
3.2
0.3
1.6
g/l
3.09
35
224
26
137
1.93
2.48
1.3
1.2
7.0
2.9
u/ml
—
5
19
26
137
1.93
2.48
1.3
1.2
2.4
8.8
u/ml
—
5
25
43
266
1.65
2.43
3.4
3.1
—
—
—
0
0
66
455
1.49
2.36
5.5
3.9
1.1
2.2
mmol/l
1.22
56
340
16
71
2.28
2.35
2.9
2.2
—
—
—
0
0
34
200
1.73
2.31
1.4
1.5
—
—
—
0
0
70
491
1.47
2.30
2.0
1.6
—
—
—
0
0
29
165
1.79
2.22
2.1
2.4
295.2
81.1
ug/min
0.48
13
100
13
54
2.43
2.20
1.0
1.1
326.0
89.0
titre
—
5
10
11
42
2.64
2.19
1.0
1.2
0.8
1.5
u/ml
—
5
19
114
879
1.35
2.18
1.3
1.2
51.6
36.9
iu/ml
0.49
37
268
8
24
3.36
2.18
1.3
1.2
—
—
—
0
0
19
95
2.02
2.12
1.3
1.2
—
—
—
0
0
267
2318
1.23
1.97
5.3
4.2
—
—
—
0
0
98
751
1.35
1.97
4.0
3.6
—
—
—
0
0
29
172
1.71
1.95
1.4
1.3
—
—
—
0
0
29
172
1.71
1.95
1.4
1.3
—
—
—
0
0
43
283
1.55
1.94
1.2
1.2
75.1
139.1
iu/ml
0.80
20
110
40
261
1.56
1.88
2.7
3.8
55.3
85.3
mg/l
0.61
29
211
40
263
1.55
1.82
2.7
3.8
50.0
95.9
mg/l
0.46
30
214
22
123
1.81
1.81
1.4
1.3
—
—
—
0
0
28
169
1.68
1.79
1.5
1.7
—
—
—
0
0
20
109
1.86
1.78
1.2
1.1
—
—
—
0
0
36
235
1.56
1.70
1.5
2.7
37.2
36.9
g/l
0.14
31
202
5
14
3.59
1.61
1.2
1.4
—
—
—
0
0
6
20
3.01
1.58
1.2
1.1
—
—
—
0
0
25
156
1.62
1.45
2.2
2.7
27.1
36.6
umol/l
1.75
18
127
25
159
1.59
1.36
1.6
1.6
—
—
—
0
0
9
42
2.16
1.34
1.2
1.5
—
—
—
0
0
20
121
1.67
1.31
1.1
1.2
—
—
—
0
0
6
24
2.51
1.30
1.2
1.0
—
—
—
0
0
103
845
1.25
1.29
1.2
1.2
4.5
12.9
u/ml
1.73
31
291
43
311
1.40
1.29
1.9
1.9
—
—
—
0
0
11
55
2.01
1.27
1.6
1.7
—
—
—
0
0
11
55
2.01
1.27
1.6
1.7
—
—
—
0
0
11
55
2.01
1.27
1.6
1.7
—
—
—
0
0
19
303
0.62
1.27
1.7
1.7
—
—
—
0
0
16
93
1.73
1.22
1.4
1.6
—
—
—
0
0
8
37
2.17
1.21
1.0
1.1
—
—
—
0
0
6
26
2.32
1.19
1.5
1.2
—
—
—
0
0
18
110
1.65
1.16
1.6
1.7
—
—
—
0
0
126
1070
1.21
1.15
1.3
1.2
0.8
1.3
u/ml
1.46
23
269
7
30
2.34
1.12
1.0
1.0
—
—
—
0
0
7
31
2.27
1.10
1.9
2.0
441.3
1151.0
u/ml
—
7
31
66
525
1.28
1.09
1.7
1.6
1.5
1.6
%
0.28
52
435
7
32
2.20
1.08
1.4
1.9
—
—
—
0
0
7
32
2.20
1.08
1.4
1.9
—
—
—
0
0
7
32
2.20
1.08
1.4
1.9
—
—
—
0
0
7
32
2.20
1.08
1.4
1.9
—
—
—
0
0
15
89
1.70
1.08
1.2
1.1
—
—
—
0
0
11
59
1.88
1.07
1.3
1.3
308.8
273.5
pmol/l
0.22
11
48
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
14
83
1.70
1.02
3.4
3.9
—
—
—
0
0
30
214
1.42
1.01
3.7
3.4
0.8
0.8
nmol/l
0.09
23
174
26
181
1.45
0.99
1.5
1.5
204.8
268.8
ug/g
0.90
16
109
0
30
0.00
0.97
0.0
2.3
—
13.4
—
0
30
9
51
1.77
0.94
1.0
1.0
—
—
—
0
0
38
287
1.34
0.93
1.9
1.8
—
—
—
0
0
10
55
1.83
0.92
1.6
1.6
—
—
—
0
0
12
71
1.70
0.89
1.8
1.3
14224.3
72274.1
e6/l
—
7
47
12
71
1.70
0.89
1.1
1.5
—
—
—
0
0
24
169
1.43
0.88
1.5
1.4
—
—
—
0
0
15
95
1.59
0.88
1.1
1.4
5528.9
28891.3
e6/l
—
8
58
8
43
1.87
0.87
1.3
1.0
—
—
—
0
0
22
154
1.44
0.84
1.6
1.7
—
—
—
0
0
10
57
1.76
0.84
2.1
2.0
—
—
—
0
0
6
32
1.88
0.82
1.7
1.6
—
—
—
0
0
0
24
0.00
0.79
0.0
1.7
—
—
—
0
0
6
33
1.82
0.79
1.7
1.5
—
—
—
0
0
22
157
1.41
0.77
2.6
2.3
16.6
15.6
%
—
8
75
10
59
1.70
0.76
1.1
1.1
—
—
—
0
0
314
2941
1.11
0.75
5.1
5.4
2.3
4.3
ug/l
0.77
274
2602
5
24
2.09
0.74
1.2
1.1
—
—
—
0
0
7
38
1.85
0.73
1.4
1.4
—
—
—
0
0
7
38
1.85
0.73
1.4
1.4
—
—
—
0
0
5
25
2.01
0.72
1.2
1.1
—
—
—
0
0
167
1511
1.13
0.72
1.8
1.8
101639732.6
8190434.5
pmol/l
0.44
122
1221
12
76
1.59
0.72
1.5
1.6
—
—
—
0
0
5
26
1.93
0.70
1.2
1.1
—
—
—
0
0
10
61
1.65
0.68
2.1
2.0
—
—
—
0
0
7
44
1.60
0.65
2.0
2.5
—
—
—
0
0
10
63
1.59
0.62
1.1
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
13
89
1.47
0.58
1.5
1.5
—
—
—
0
0
6
35
1.72
0.57
1.2
1.4
—
—
—
0
0
6
35
1.72
0.57
1.2
1.4
—
—
—
0
0
19
141
1.36
0.56
1.4
1.5
—
—
—
0
0
10
66
1.52
0.52
1.1
1.2
—
—
—
0
0
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
93
832
1.13
0.51
6.0
4.7
31.2
32.7
%
0.74
72
550
11
75
1.47
0.51
1.1
1.0
—
—
—
0
0
20
153
1.31
0.50
2.1
2.0
129.5
127.8
g/l
0.06
11
114
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
6
41
1.47
0.50
1.7
1.5
—
—
—
0
0
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
20
154
1.31
0.49
1.2
1.3
—
—
—
0
0
86
769
1.13
0.48
3.7
4.2
12.3
18.3
ug/l
0.30
74
656
7
48
1.46
0.47
1.1
1.5
—
—
—
0
0
7
48
1.46
0.47
1.1
1.5
—
—
—
0
0
11
77
1.43
0.45
3.4
2.8
—
—
—
0
0
14
103
1.37
0.45
2.0
1.9
86.5
89.3
%
0.75
14
103
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
15
114
1.32
0.41
1.5
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
8
111
0.72
0.37
1.1
1.1
—
—
—
0
0
19
152
1.26
0.37
2.1
1.6
—
—
—
0
0
5
37
1.35
0.37
5.0
3.4
208.4
116.4
nmol/l
—
5
37
13
101
1.29
0.32
1.6
1.5
—
—
—
0
0
10
75
1.34
0.30
1.3
1.7
—
—
—
0
0
15
122
1.23
0.27
2.1
1.6
2.7
6.4
iu/l
—
5
33
17
141
1.21
0.26
1.0
1.1
—
15.2
—
0
8
10
77
1.30
0.26
1.3
1.6
—
—
—
0
0
10
77
1.30
0.26
1.3
1.6
—
—
—
0
0
9
77
1.17
0.24
1.1
1.3
—
—
—
0
0
13
106
1.23
0.23
2.3
2.8
4.0
4.6
e9/l
0.66
13
106
18
211
0.85
0.23
1.0
1.0
—
—
—
0
0
11
88
1.25
0.22
1.9
1.5
200.2
433.7
pmol/l
0.58
11
88
48
523
0.91
0.22
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
62
579
1.08
0.19
3.2
3.7
1.2
1.2
mmol/l
0.48
54
505
11
90
1.23
0.19
1.5
1.5
—
—
—
0
0
13
109
1.20
0.18
2.4
3.0
54.5
60.3
%
1.03
13
109
23
258
0.89
0.18
1.4
1.8
—
—
—
0
0
163
1676
0.97
0.13
3.2
3.3
0.8
0.8
ug/l
0.18
114
1164
241
2365
1.03
0.11
4.7
4.6
23.4
21.4
%
1.05
122
1202
5
60
0.83
0.08
1.4
1.8
—
—
—
0
0
5
63
0.79
0.08
1.8
1.3
—
—
—
0
0
5
64
0.78
0.08
1.0
1.1
—
—
—
0
0
8
78
1.03
0.07
1.4
1.6
—
—
—
0
0
8
78
1.03
0.07
1.4
1.6
—
—
—
0
0
8
90
0.89
0.06
1.8
2.0
—
—
—
0
0
21
222
0.94
0.05
1.4
1.7
—
—
—
0
0
50
493
1.02
0.01
1.9
2.1
12.0
12.4
nmol/l
0.06
40
431
11
115
0.96
0.00
1.0
1.1
—
—
—
0
0
11
108
1.02
0.00
1.3
1.3
—
—
—
0
0
14
138
1.01
0.00
1.8
1.6
—
—
—
0
0
14
142
0.99
0.00
1.2
1.7
41.5
42.4
nmol/l
0.05
14
135
23
228
1.01
0.00
2.8
3.0
38.6
70.7
u/ml
0.80
23
220
65
647
1.01
0.00
1.4
1.4
—
—
—
0
0
8
79
1.01
0.00
1.4
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
0.00
1.7
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
80.2
—
0
5
9
96
0.94
0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_OTHRETARTOCC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHRETARTOCC | 1.324 [1.16, 1.52] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.249 |
During the follow-up period (1.1.1998 — 31.12.2019), 627 out of 1845 females with H7_OTHRETARTOCC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHRETARTOCC | 1.387 [1.22, 1.58] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1009 out of 2645 males with H7_OTHRETARTOCC died.
Mortality risk
Mortality risk for people of age
years, who have H7_OTHRETARTOCC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.239% |
| 5 | 0.758% | 1.507% |
| 10 | 1.952% | 3.968% |
| 15 | 3.719% | 7.186% |
| 20 | 6.363% | 11.684% |
Relationships between endpoints
↥Index endpoint: H7_OTHRETARTOCC – Other retinal artery occlusion
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data